155例酒精性肝病患者临床特征分析

155例酒精性肝病患者临床特征分析
叶茂聪;李阳;肖丽;杨秀珍;耿爱文;沈美龙;咸建春;徐洪涛
【期刊名称】《实用肝脏病杂志》
【年(卷),期】2017(020)001
【摘要】Objective To summarize the clinical characteristics of patients with alcoholic liver disease (ALD). Methods The clinical data of 155 patients with ALD were retrospectively analyzed from January 2014 to July 2015 in the Taizhou People's Hospital. Results Out of 155 cases,there were alcoholic fatty liver(AFL) in 24, alcoholic hepatitis (AH) in 83 and alcoholic cirrhosis (AC) in 48. The farmers and self-employed businessmen accounted for 34.8% and 21.9%,respectively;The average age was
(55.5±12.2) yr old,middle-aged (45 to 59 yr old) were 44.5%;The average age of patients with AC was (63.1±12.3) yr old,significantly greater than (49.7±7.2) yr old in patients with AFL or (52.9±11.3) yr old in patients with AH (P<0.05);The average ethanol intake in patients with AC
was(157.5±69.3) g/d,significantly higher than(105.7±50.6) g/d in patients with AFL or (125.3±66.4) g/d in patients with AH (P<0.05);The average drinking period in AC patients was (31.7±12.0) yrs,significantly longer than (22.6±6.7) yrs in patients with AFL or(22.9±10.1) yrs in patients with
AH(P<0.05);Logistic analysis showed that the age,ethanol intake and drinking period were independent risk factors for alcoholic liver cirrhosis;serum elevated GGT levels was found in 69.0%,increased
erythrocyte mean corpuscular volum (MCV) was in 38.1 % and ratio of
AST/ALT>2 was in only 17.4%. Conclusions Patients with ALD were mainly
in middle-aged men. Age,ethanol intake and drinking period are risk factors for liver cirrhosis in ALD patients. The ratio of AST/ALT,serum GGT levels and MCV are not good indicators for patients with ALD, and the diagnosis might be dependent on comprehensive clinical data.%目的：分析酒精性肝病（ALD）的临床特点，进一步提高ALD的诊治水平。

方法对2014年
1月～2015年7月在泰州市人民医院住院的155例ALD患者的临床资料进行回
顾性分析。

结果在155例患者中，酒精性脂肪肝（AFL)24例（15.5%），酒精性肝炎（AH)83例（53.6%），酒精性肝硬化（AC）48例（31.0%）；农民和个体经营者分别占34.8%和21.9%；平均年龄为（55.5±12.2）岁，45～59岁中年占44.5%；AC患者的平均年龄为（63.1±12.3）岁，显著大于AFL患者的
（49.7±7.2）岁和AH患者的（52.9±11.3）岁（P<0.05）；AC患者的乙醇摄入量为（157.5±69.3） g/d，显著大于AFL患者的（105.7±50.6）g/d和AH患者的（125.3±66.4）g/d（P<0.05）；AC患者的平均饮酒年限为（31.7±12.0）年，显著长于AFL患者的（22.6±6.7）年和AH患者的（22.9±10.1）年（P<0.05）；多元回归分析显示，年龄、乙醇摄入量和饮酒年限是ALD患者发生肝硬化的危险
因素；69.0%患者血清GGT升高，17.4%患者AST/ALT比值>2，38.1%患者红
细胞平均体积（MCV）增大。

结论 ALD患者主要为中年男性，以农民和个体经营者为主。

年龄、乙醇摄入量和饮酒年限为ALD发生肝硬化的危险因素。

AST/ALT 比值>2、GGT升高和MCV增大还很难作为ALD的临床特点加以应用。

【总页数】5页(P60-64)
【作者】叶茂聪;李阳;肖丽;杨秀珍;耿爱文;沈美龙;咸建春;徐洪涛
【作者单位】225300 江苏省泰州市南通大学附属泰州市人民医院肝病科;225300 江苏省泰州市南通大学附属泰州市人民医院肝病科;225300 江苏省泰州市南通大学附属泰州市人民医院肝病科;225300 江苏省泰州市南通大学附属泰州市人民医院肝病科;225300 江苏省泰州市南通大学附属泰州市人民医院肝病科;225300 江苏省泰州市南通大学附属泰州市人民医院肝病科;225300 江苏省泰州市南通大学附属泰州市人民医院肝病科;225300 江苏省泰州市南通大学附属泰州市人民医院肝病科
【正文语种】中文
【相关文献】
1.酒精性肝病合并慢性酒精中毒性脑病临床影像学特征分析 [J], 李昆;刘炜
2.泰州地区273例酒精性肝病患者的实验室检查特征分析 [J], 叶茂聪;李阳;肖丽;杨秀珍;张会;王变;耿爱文;徐洪涛;咸建春
3.酒精性肝病79例临床特征分析 [J], 郭宝娜;展玉涛
4.酒精性肝病患者的中医体质特征分析 [J], 姚志山;吴云;张文静;李术先;王巍;毛宇湘
5.劳拉西泮与奥沙西泮治疗酒精性肝病并发酒精戒断综合征患者临床疗效对比研究[J], 刘丽霞;林应源;李华敏;蔡水苗
因版权原因，仅展示原文概要，查看原文内容请购买。