ANTIBODIES WITH T-CELL RECEPTOR LIKE SPECIFICITY T
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专利名称：ANTIBODIES WITH T-CELL RECEPTOR LIKE SPECIFICITY TOWARDS NATIVE COMPLEXES
OF MHC CLASS II AND DIABETES-
ASSOCIATED AUTOANTIGENIC PEPTIDES
发明人：REITER, Yoram,DAHAN, Rony
申请号：EP11746669.8
申请日：20110714
公开号：EP2593480A2
公开日：
20130522
专利内容由知识产权出版社提供
摘要：Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated autoantigenic peptide, the isolated complex having a structural conformation which enables isolation of a high affinity entity which comprises an antigen binding domain capable of specifically binding to a native conformation of a complex composed of the MHC class II and the type I diabetes-associated autoantigenic peptide. Also provided are isolated high affinity entities comprising an antigen binding domain capable of specifically binding a complex composed of a major histocompatibility complex (MHC) class II and a type I diabetes-associated autoantigenic peptide, wherein the isolated high affinity entity does not bind to the MHC class II in an absence of the diabetes-associated autoantigenic peptide, wherein the isolated high affinity entity does not bind to the diabetes-associated autoantigenic peptide in an absence of the MHC class II; and methods and kits using same for diagnostic and therapeutic purposes.
申请人：Technion Research & Development Foundation Ltd.
地址：Senate House Technion City 32000 Haifa IL 国籍：IL
代理机构：Raukema, Age
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