1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI MYCOBA

专利名称：1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR ANTI MYCOBACTERIAL ACTIVITY
发明人：Dhiman Sarkar,Sunita Ranjan
Deshpande,Shailaja Pramod Maybhate,Anjali,
Prabhakar Likhite,Sampa Sarkar,Arshad
Khan,Preeti Madhukar Chaudhary,Sayalee
Ramchandra Chavan
申请号：US13634352
申请日：20110314
公开号：US20130060045A1
公开日：
20130307
专利内容由知识产权出版社提供
摘要：Invention provides antitubercular compounds selected from propargylated 1,2,3 triazoles of Formula I, wherein, X is sulfur (S) or a sulphone (A), n, m represent independently an integer O or 1, with the provision that when ‘n’ is 1, ‘m’ is 1; R1 is hydrogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group; halogen; or aryl group optionally substituted with —OCH3, halogen, and nitro; R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms; Z is C1-C6 alkyl optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with arylalkyl, linear or branched
alkenyl, substituted alkenyl, alkynyl, substituted alkynyl allyl or propargyl groups consisting of 1 to 6 carbon atoms; with the provision that when ‘m’ is 1, and ‘n’ is zero; R1 is selected from the group consisting of hydrogen, halogen; C1-C6 linear or branched alkyl group optionally substituted with aryl group or aryl group optionally substituted with —OCH3, halogen, and nitro, R2 and R3 are selected from the group consisting of hydrogen, C1-C6 alkyl optionally substituted with heterocyclic ring of 5 to 6 ring atoms containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, which may be substituted with alkyl, arylalkyl, linear or branched alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or allyl or propargyl groups consisting of 1 to 6 carbon atoms; Z is selected from the group consisting of halogen, C1-C6 linear or branched alkyl group optionally substituted with heterocyclic ring of 1 to 6 ring atoms, containing one to three hetero atoms selected from oxygen, sulfur, nitrogen, wherein the heterocyclic ring may further be substituted with halogen, alkyl, arylalkyl.
申请人：Dhiman Sarkar,Sunita Ranjan Deshpande,Shailaja Pramod Maybhate,Anjali, Prabhakar Likhite,Sampa Sarkar,Arshad Khan,Preeti Madhukar Chaudhary,Sayalee Ramchandra Chavan
地址：Pune IN,Pune IN,Pune IN,Pune IN,Pune IN,Pune IN,Pune IN,Pune IN
国籍：IN,IN,IN,IN,IN,IN,IN,IN
更多信息请下载全文后查看。