Free-Knot Spline Approximation of Stochastic Processes
代谢工程概述-PPT
(1)基因工程技术的应用 (2)常规诱变技术的应用
2、 生物合成途径的代谢调控
(1)生物合成中间产物的定量生物测定 (2)共合成法在生物合成中的应用 (3)酶的诱导合成和分解代谢产物阻遏
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3、研究生物合成机制的常用方法
(1)刺激实验法 (2)同位素示踪法 (3)洗涤菌丝悬浮法 (4)无细胞抽提法 (5)遗传特性诱变法
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• 1. 生物能支撑观点 • 微生物细胞是工业发酵产物的生产者,微生物细胞的
生长和维持需要由其自身的能量转换机构或从其他形 式的能量转化形成的生物能来支撑。因此,工业发酵 具有生物学属性。
• 2. 代谢网络观点 • 由生化反应网络和跨输送步骤组成的代谢网络既没有
绝对的起点,也没有绝对的终点。代谢网络中任何一 种中间产物(或可借助生物学、化学方法与代谢网络联 网的任何一种化合物)都可能被开发成为工业发酵的目 的产物或原料。
简而言之,代谢工程是生物化学反应代谢网络有目的 的修饰。
代谢工程要解决的主要问题就是改变某些途径中的碳 架物质流量或改变碳架物质流在不同途径中的流量分布。 其目标就是修饰初级代谢,将碳架物质流导入目的产物 的载流途径以获得产物的最大转化率。
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代谢工程的主要特征就是利用DNA重组技术, 重建代谢网络,改变代谢流及分支代谢速度, 以改进代谢产物及蛋白类产品,由于外源 DNA的引入扩展了固有的代谢途径,获得了 新的化学物质。改变转化蛋白的过程,减少 不必要的废物。例如,谷氨酸发酵
“中心途径”和“离心途径”等连续的代谢途径的代谢,才能在胞内生成目的
产物,最后,目的产物跨过细胞质膜排出细胞回到培养介质中。
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1、胞外酶对原料的降解及营养物质进入细 胞的过程 2、经胞内降解代谢途径汇入中心代谢途径 3、中心代谢途径及其控制 4、合成代谢流及其控制 5、目的产物的跨膜及其控制
Sennheiser IE 100 PRO Wireless产品说明书
with Bluetooth® connectorFEATURES• Dynamic full-range transducer for high-resolution,powerful monitoring sound• Reduces acoustic stress factors through natural anddistortion-free reproduction• 2 in 1 bundle: Bluetooth® module for wireless connec-tion to mobile devices, PCs or tablets, with a built-inmicrophone for calls or standard 3,5 mm jack-plugcable• Excellent shielding through optimized earpiece shapeand flexible silicone and foam attachmentsFor the stage. For massive sound. For the road.Developed for high expectations on live stages, the specially designed driver of the IE 100 PRO creates precise audio cla-rity for musicians in live sessions. Typical for the new type of membrane is a powerful, high-resolution and warm monito-ring sound. With the included Bluetooth® module, the in-ears become comfortable everyday companions for your mobile phone, PC or tablet. With the built-in mic, phone calls or Webcasts are also possible.Musicians and DJs choose the IE 100 PRO wireless set for its exceptional sound and high wearing comfort. Not only for live sessions, but also for producing on the road or as an everyday companion.The in-ears come with 4 earpiece adapters that optimize the fit for every ear size and shape. The setup is stage-safe from the connection to the cable conduit.Sophisticated monitoring sound for mixing on live stages, producing in the studio and everywhere in between.DELIVERY INCLUDES• IE 100 PRO (BLACK, CLEAR or RED)• Bluetooth connector• black cable for IE 100 PRO• USB-A to USB-C cable• soft pouch• cleaning tool• foam and silicone ear adapters• quick guide• safety guide• compliance sheetwith Bluetooth® connectorPRODUCT VARIANTSIE 100 PRO WIRELESS BLACKArt. no. 509171IE 100 PRO WIRELESS CLEAR Art. no. 509172IE 100 PRO WIRELESS RED Art. no. 509173SPECIFICATIONS IE 100 PROFrequency response 20 - 18,000 Hz Impedance20 ΩSound pressure level (SPL)115 dB (1 kHz / 1 V rms )Total harmonic distortion (THD)< 0.1 % (1 kHz, 94 dB)Noise attenuation < 26 dB Magnetized field strength 1.63 mT Operating temperature Storage temperature –5 °C to +50 °C (23 °F to 122 °F)–20 °C to +70 °C (–4 °F to 158 °F)Relative humidity< 95 %Bluetooth ® ConnectorWearing style Bluetooth® neckband cable Microphone principle MEMS Microphone frequency response100 - 8,000 HzMicrophone sensitivity -42 dBV/Pa (ITU-T P.79)Microphone pick-up pattern (speech audio)omni-directional Power supply - built-in rechargeable lithium- polymer battery 3.7 V ⎓, 100 mAhUSB charging 5 V ⎓, 100 mA max.Operating time10 h (music playback via SBC) with rechargeable battery;240 h in standby mode Charging time ofrechargeable batteries approx. 2.5 hOperating temperature Charging temperature Storage temperature +5 °C to +40 °C ± 5 °C (41 °F to 104 °F ± 9 °F)+10 °C to +40 °C ± 5 °C (50 °F to 104 °F ± 9 °F)–20 °C to +70 °C (–4 °F to 158 °F)Relative humidity Operation: Storage:10 - 80 %, non-condensing 10 - 90 %Magnetized field strength1.63 mT (with IE 100 PRO)0.23 mT (without headphone)Weight approx. 13 gBluetooth®VersionBluetooth 5.0 compatible,class 1, BLETransmission frequency 2,402 - 2,480 MHz Modulation GFSK, π/4 DQPSK, 8DPSK Profiles HSP, HFP, AVRCP, A2DP Output power 10 mW (max)CodecSBC, aptX®, aptX LL®, AACThe Bluetooth® word mark and logos are registered trade-marks owned by Bluetooth SIG, Inc. and any use of such marks by Sennheiser electronic GmbH & Co. KG is under license.with Bluetooth® connectorSennheiser electronic GmbH & Co. KG · Am Labor 1 · 30900 Wedemark · Germany · ACCESSORIESIE PRO Bluetooth Connector Art. no. 508943IE PRO Mono cable Art. no. 508944Twisted cable Art. no. 507478Black straight cableArt. no. 508584。
Volvo I-Shift 自动变速箱操作手册说明书
I-Shift drive modes and software functionsThe I-Shift gearboxʼs functions are optimized with specially adapted drive modes, which make the gearbox even more practical and economical by adapting the gearshift functional-ity to the current transport conditionsThe driving mode is selected with a button on the gear se-lector. Fuel saving functions are adjusted according to the se-lected drive mode. I-See (optional) speed limits and strategy are adjusted according to the selected drive mode.Drive modes•Economy: Focus on lowering fuel consumption, some re-duction in power. Using I-See function.•Standard: Reasonable fuel consumption without compro-mising drivability. Using I-See function.•Performance: Full power, with less focus on fuel consump-tion.•Off-road: Agility is prioritised.•Heavy duty: Optimised for drivability and comfort at high loads (Heavy Equipment Transport).Sales variantsDrive modeDRM-E I-Shift drive mode economyDRM-BE I-Shift drive mode balanced economyAMT vocation optionAVO-BAS Basic I-Shift softwareAVO-ENH Enhanced I-Shift software including construc-tion and off-road applicationsAVO-HD Enhanced I-Shift software including heavy du-ty, construction and off-road applicationsTransmission performance modeTPM-AUTR Transmission performance mode auto return TPM-MAN Transmission performance mode manual UTPM Without drive mode performance in DRM-BEAMT manual shift optionsAMSO-BAS Basic I-Shift gear shiftingAMSO-AUT I-Shift manual gear shift available in automatic mode incl kickdown functionAMT PTO functionsAPF-BAS Basic I-Shift PTO functionsAPF-ENH Enhanced I-Shift PTO functions (Auto Neu-tral/ Reverse Inhibit / Split Box Connection)FEATURES AND BENEFITS•Optimized drivability.•Reduce fuel consumption.•Reduce CO2 footprint.•Simplify selection of drive modes.FACT SHEETI-Shift drive modesI-Shift drive modes icons in instrument cluster.I-Shift drive modes and software functions● Standard, ○ Option, — Not available1Note! Choice of UTPM gives no Performance drive mode.DRM-E+AVO-BAS is designed for long haul transport to secure a good fuel economy.DRM-BE+AVO-BAS is the versatile offer for the majority of the transport segments.DRM-BE+AVO-ENH is adapted for construction operations.DRM-BE+AVO-HD is specially tailored for heavier transport operations.FACT SHEETI-Shift drive modesI-Shift software functions● Standard, ○ Option, — Not available2Only AT2612, ATO2612, ATO3112 and ATO3512.3For Volvo FH16 or for a Volvo with driven front axle.FACT SHEETI-Shift drive modesI-Shift Drive Mode Economy (DRM-E)DRM-E is optimized for fleet usage were driver influence is limited. To access I-See functionality, PVT-MAP needs to be added.This drive mode restricts the possibility to alter among the drive modes. The DRM-E will be locked in Economy mode. I-Shift Drive Mode Balanced Economy (DRM-BE)This is the base which giving ideal selection for most all ap-plications. To optimize further toward a particular vocation, DRM-BE is selected with AVO-BAS, AVO-ENH or AVO-HD. For customer usages with frequent start and stop like garbage collection, a potential to save fuel is to remove the possibility to access performance driving mode. That variant exist for DRM-BE and is called UTPM.For DRM-BE with UTPM, the performance drive mode is removed and consequently also the option with TPM-AUTR. Other options in DRM-BE with UTPM are available like AVO-ENH/AMSO-AUT/APF-ENH.Basic Vocational Functions (AVO-BAS)Allows the driver to choose between the Economy, Standard and Performance driving modes.Enhanced Performance – Bad Roads (AVO-ENH)This optional package is specially adapted to the specific con-ditions of the construction and timber transport segments. The Off-road mode includes various functions that adapt gearshifts and gear selection to poor driving surfaces and hilly gradients. It also includes functions that facilitate starting from standstill in poor driving conditions.Off-road mode is designed to minimise the number of gearshifts required. This is useful during off-road driving. It prevents wheels from spinning out when torque is increased after a gearshift, and prevents missed gearshifts, for example if the road gradient changes sharply. High engine power (high revs) is often required when driving uphill.The driver can also influence the maximum number of down shifts. This is very useful when you shift to a lower gear on a very steep uphill gradient and only want to shift once to a gear strong enough to take you all the way up. Economy, Standard, Performance and Off-road driving modes are available. Summary of the functions in the package:•Engine revs are increased as necessary to provide extra torque when starting off from standstill.•Larger margins before upshifts ensure safer driving if the gradient changes.•Gear selection is adapted to minimise the number of gearshifts and run at slightly higher revs.•Functions that make it easier to keep the same gear when the accelerator pedal position and road gradient change.•The package enables multiple downshifts. This facilitates gearshifts when driving up steep slopes.•Includes a function that speeds up clutch release and makes it easier to rock the vehicle out of trouble if it gets stuck on a soft surface.•When moving the gear lever, the driver can choose the gear that provides the highest possible engine speed. Enhanced Performance – Heavy duty (AVO-HD)AVO-HD optimizes I-Shift for heavy duty transport with high gross combination weights (>85 tonnes). Regardless of the gross combination weight, the driver can always optimize dri-vability by selecting or deactivating the Heavy Duty mode, and activating the long haul mode. The functions in the software package also offer benefits for trucks hauling multiple trailers. AVO-HD also includes AVO-ENH functions (Off-road mode)but the functions in Off-road are only active when the Heavy Duty mode is inactive.Change DirectionEnables fast change of driving direction in for instance maneuvering situations by change direction functionality. Change direction is to select reverse gear at lower vehicle speed and use the accelerator pedal to brake the vehicle and start reversing without letting the foot of the accelerator pedal. Vice versa applies, i.e. reversing the vehicle and thenFACT SHEETI-Shift drive modespush the gear selector into A/M and use accelerator pedal to come into forward driving. Pressing the accelerator pedal more makes the event of changing driving direction to occur faster. Change Direction is activated up to 30 km/h.Note! Change Direction requires AVO-ENH or AVO-HD. Terrain BrakeTerrain brake gives improved off-road agility for Volvo FH16 or for a Volvo with driven front axle.With this function, the driver controlling the vehicle better. For instance, rolling off a stone in terrain, is made in a con-trolled manor by the driver activation.Terrain brake means that the brake is applied when the ac-celerator pedal is released and consequently holds the truck in the position inhibiting free rolling. Terrain brake can be en-gaged below 4 km/h, i.e. at low speeds. Applied terrain brake force is controlled by the retarder brake lever position on the steering column.Note! Terrain Brake requires AVO-ENH or AVO-HD. Transmission Performance Mode Auto Return (TPM-AUTR)Transmission performance mode AUTR. Auto return to drive mode Economy.Enable manual switch (TPM-MAN)Transmission performance mode MAN. Enable manual switch between Economy and Performance mode.Basic Gear Selection Adjustment (AMSO-BAS) Allows the driver to adjust gear selection with the gear lever buttons during engine braking in Automatic mode (gear selec-tor position A).Enhanced Gear Selection Adjustment,incl. Kickdown (AMSO-AUT)This function allows both the automatically selected starting gear and the driving gear in Automatic mode to be adjusted by activating the plus/minus button on the gear lever.The kickdown function selects a gear for maximum acceler-ation. When the kickdown switch on the accelerator pedal is engaged, the system changes the gearshift strategy to max-imise vehicle acceleration. When suitable (e.g. depending on engine speed), this leads to a downshift.Basic PTO Functions (APF-BAS)Facilitates power take-off operation. Pre-defined splitter gear positions determine which splitter gear is used when one or two gearbox power take-offs are engaged.Because gear selection is matched to the engine speed lim-it, it is possible to set parameters for the software. The gear selection is then adapted to any engine speed limits imposed by body-builder functions.Enhanced PTO Functions (APF-ENH)Several functions that aid power take-off operation. I-Shiftʼs power take-off functions make it possible to activate the prop-erties listed below by having the software parameters adjust-ed at an authorised workshop.•Auto Neutral: On command, the driveline is disconnected from the bodybuilder control unit, regardless of the gear leverʼs position, when Auto Neutral is activated.•Reverse Inhibit: When the bodybuilder control unit is-sues the Reverse Inhibit command, the reverse gears are blocked by the transmission system.•Connection of splitter box: Allows connection of a splitter box for operation of high-capacity power take-offs. Direct gear is activated when the bodybuilder module is put in splitter box mode. It is also possible to use all high range gears. Please look into the body builder instructions. Performance ShiftGives faster, gentler shifts through intelligent utilisation of the engineʼs compression brake (VEB brakes), the vehicleʼs clutch and a special gearbox brake.Automatic selection of correct starting gear (1st – 6th gear)is included. The choice of starting gear is determined by gross vehicle weight and road gradient.Gearbox Oil Temperature MonitorContinuously shows the gearbox oil temperature in the infor-mation display.Heavy Start EngagementFor start-up with high revs in Performance mode in 1st gear,resulting in higher starting torque. This function raises the revs to facilitate heavy starts. This is useful, for instance, if the truck is stuck in soft ground.I-RollAutomatic activation and deactivation of a freewheel function in order to cut fuel consumption, which can be reduced by up to several percent. I-Roll is used when neither engine power nor engine braking is needed, for instance on flat roads. When driving with cruise control, I-Roll runs at roughly 1–3 km/h be-low the pre-set speed, which saves fuel. The longer the vehi-FACT SHEETI-Shift drive modescle drives using I-Roll, the more fuel is saved.Smart Cruise ControlInteracts with the vehicleʼs Brake Cruise and ensures that the auxiliary brakes are not activated unnecessarily. The auxiliary brakes are deactivated on downhill stretches to save fuel. This allows increased use of the freewheel function, resulting in improved fuel efficiency.Downhill Cruise ControlDownhill Cruise Control sets a maximum speed to control the vehicle speed in a down-hill.Downhill Cruise Control primarily uses the auxiliary brakes such as the Volvo Engine Brake or the retarder to make sure that the selected speed is not exceeded. Only when required, the wheel brakes are applied.The driver can still use the brake pedal to further lower the speed without deactivating the system.Launch ControlOptimizes gear selection and EBS functions when manoeu-vring at low speeds. Manoeuvring is facilitated because the EBS brakes are automatically engaged when the truck changes direction. This also ensures that the Auto Hold func-tion is activated.It is possible to drive the vehicle forward with the idle regu-lator. This saves unnecessary downshifts and makes it easier to adjust the vehicleʼs speed, for instance when driving in traf-fic queues.Enhanced Shift Strategy4By interacting with EBS 5 and ECS 6, both starting and ma-noeuvring are made easier.This brake mode maximises VEB/VEB+/retarder braking effects by automatically selecting the appropriate gear so the engine runs at high revs. This function compensates for the engine brake when changing gears in brake mode.When changing gears during engine braking, the wheel brakes are activated to compensate for braking moment. This raises braking power and provides smoother gearshifts. Interaction with the braking systems increases safety by preventing the truck from accelerating during gearshifts on steep slopes when braking mode is activated.Heavy Duty GCW Control7Optimizes gear selection for high gross combination weights(according to heavy haulage document). This function improves drivability and fuel economy in the heavy duty trans-port segment. Heavy Duty GCW Control gives the driver ac-cess to the HD (Heavy Duty) driving mode.In HD mode, 1st gear is used as the starting gear and gear selection is adapted to heavier gross combination weights. The gearshifts generally occur at higher revs. HD is activat-ed and deactivated by pressing and holding the modes button on the gear selector for about 3 seconds. The chosen driving mode remains selected when the engine is turned off. Among other things, the DRM-BE-AVO-HD function se-lects the starting gear to suit the gross combination weight, thereby saving the clutch. The entire gear range is utilised, and the gears are changed consistently at high revs to maintain torque and driving comfort.When driving with low gross combination weights or with-out a load, it is easy to deactivate the HD driving mode and return to Economy mode. After this, the driver can switch be-tween available drive modes. This ensures comfortable and fuel efficient driving.Heavy ModeHeavy mode function for trucks with I-Shift - having rear axle RTH3815 - regardless of emission class is as follows:•For driving without load all drive modes can be used.•For driving with load all drive modes - except Economy -can be used. When driving downhill with load - the gear-box shifts down, corresponding to retarder lever position 3. The purpose of downshift is to raise the engine speed to provide more engine braking power to the truck.4 Full functionality requires EBS-MED.5 EBS = Disc Brakes with Electronically controlled Brake System (EBS-STD / EBS-MED)6 ECS = Electronically Controlled Suspension (SUSPL-EC).7 Available only with certain engine/gearbox combinations.Volvo Tech ToolI-Shiftʼs software packages can easily be installed and changed with the help of Volvoʼs analysis and programming tool, Volvo Tech Tool. This is done by authorised dealers and workshops,where the software packages can be further cus-tomised with optional functions and customer parameters. Customer parametersI-Shift also has many options for setting customer parame-ters that optimize the vehicleʼs driving properties in specialFACT SHEETI-Shift drive modesapplications and special transport segments. For instance,the starting gear can be optimized according to the transport conditions. Power take-off operation can also be customised.Customised settings and reprogramming of I-Shift are car-ried out at authorised workshops using the Volvo Tech Tool.FACT SHEETI-Shift drive modes。
瓜环试剂的发展及应用研究
168化学试剂2021年2月DOI:10.13822/ki.hxsj.2021007802化学试剂,2021,43(2) ,168〜173瓜环试剂的发展及应用研究余诗雨,刘智敏,杨怡,时开存,唐思静,李娇,蔡晓丽,张雪花,许志刚•(昆明理工大学理学院,云南昆明650500)摘要:瓜环是超分子领域中的一类备受关注的新兴大环化合物,但由于其溶解度小、活性基团少、难以衍生化等因素,一定程度上限制其发展和广泛应用。
简要介绍了瓜环的发展历程,全面介绍了常见瓜环化合物的合成、分离与表征,进一 步介绍了各种衍生化瓜环,重点介绍了各种瓜环在分子包结与识别和分子催化等方面的应用,讨论了瓜环类试剂发展中 存在的问题及发展趋势。
将为从事功能材料、吸附分离方法和超分子化学等方面的研究人员提供有益的参考。
关键词:瓜环;超分子;分子包结;分子催化;试剂中图分类号:0601; 0656.4 文献标识码:A文章编号:0258-3283 (2021)02-0168-06Development of Cucurbit [/i ] urils and Its Applications YU S h i-y u,L I U Z h i-m i n.Y A N G Y i^S H I K a i-c u n,T A N G S i-j i n g, LI J i a o,C A I X i a o-l i,Z H A N G X u e-h u a,X U Z h i-g a n g *(F a c u h y of Science, Kunming University of Science and Technology, Kunming 650500,C h in a),Huaxue Shiji,2021,43(2),168〜173Abstract:Cucurbit[ «] urils are a kind of emerging macrocyclic compounds that has attracted much attention in the field of supra-molecular. However, the development and application of Cucurbit[ «] urils are limited to a certain extent due to its low solubility, few active groups,and difficulty in derivatization.The development history of Cucurbit[ re] urils was briefly presented firstly.Then, the synthesis,separation and characterization of common Cucurbit[ n] urils were comprehensively introduced. And some derivatized Cucurbit [ n] urils were further introduced.The recent applications of Cucurbit[«] urils in molecular inclusion and recognition ,and molecular catalysis, were introduced.Finally, the urgently problems in the development of Cucurbit[ n] urils reagents and its development trends were also discussed.The work will provide a useful reference for researchers engaged in functional materials, adsorption and separation methods,and supramolecular chemistry.Key words : Cucurbit [ n] urils ;supramolecular; molecular inclusion ; molecular catalysis ; reagent瓜环(Cucurbit [ n ] urils,CB [ n ]),是继杯芳烃、冠醚、环糊精后备受关注的一类大环主体分子[|_3],瓜环的诞生为超分子化学注人了新的血液。
开口箭皂苷抗炎活性的研究(1)汇总
开口箭皂苷抗炎活性的研究(1)【关键词】开口箭;,,皂苷;,,抗炎摘要:目的评价开口箭总皂苷的抗炎活性。
方法采用系统溶剂萃取,运用角叉菜胶所致小鼠足肿胀模型和脂多糖刺激小鼠腹腔巨噬细胞产生一氧化氮细胞模型对开口箭不同提取部位的抗炎活性进行研究。
结果开口箭水溶性浸膏、正丁醇萃取物、石油醚萃取物对角叉菜胶所致小鼠足肿胀及肿胀足中前列腺素E2含量升高均具有显著抑制作用(P<0.01)。
其总皂苷经大孔树脂吸附,30%,70%,95%乙醇洗脱,各洗脱部分对脂多糖刺激腹腔巨噬细胞产生 NO均有显著抑制作用(P<0.01)。
结论开口箭具有良好的抗炎作用,具有良好的开发利用价值。
皂苷是其抗炎的重要物质基础之一。
抑制炎症介质 PGE2,NO的产生是其作用机理之一。
关键词:开口箭;皂苷;抗炎Study on Anti-inflammatory Activity of Total Saponin from Tupistra chinensis Bak.Abstract:ObjectiveTo evaluate the anti-inflammatory activity of total saponin from Tupistra chinensis Bak.MethodsCompared the anti-inflammatory activity of the different parts, adopted systematic solvent extraction,used the mouse's foot swell model caused by carrageenin ,used the cell model that lipopolysaccharide excited preitoneal macrophage produced nitrogen monoxidum.ResultsWater-soluble extract,n-butanol extract and petroleum benzine extract inhibited the foot swell ,decreased the quantity of prostaglandinE2(P<0.01).The total of saponin was absorbed by macroporousresin,then eluted by 30% alcohol,70%alcohol and 95% alcohol.Different parts decreased the quantity of nitrogen monxidum produced by peritoneal macrophage(P<0.01).ConclusionTupistra chinensis Bak.has good anti-inflammatory activity and favorable exploitationvalue.Saponin is very important substance for anti-inflammation. The mechanism is to decrease the quantity of mediators of inflammation like prostaglandin E2,nitrogen monoxidum.Key words:Tupistra chinensis Bal; Saponin; Anti-inflammation开口箭为百合科植物开口箭Tupistra chinensis Bak.的干燥根茎。
以色列二穗短柄草谷胱甘肽过氧化物酶活性分析
Y N J n’ X EW nto, E Y W N i — e , H N u. ag , H N a -i ( . o A u , U e— H a , A GXn m i Z O GG i in 。 C E GJ npn a e g x i g 1 C1 .
ro . Alo,sg i c n i ee c r b e v d a n 0 c tp s ot s i f a tdf rn eweeo s r e mo g1 5 e oy e .Ex e tr o ,e c ft eGS P cii n i c p o t a h o h H— x a tv—
由遗传 决定的 , 为模式植物的遗传 差异性对于禾谷 类植物 的遗传和基 因比较分析 等极具价值。 作 关键词 : 式植物 ; 色列; 模 以 二穗短 柄草 ; 胱甘肽过氧化物酶 谷
中 图分 类 号 :9 53 Q 4 .5 文献标识码 : A 文 章 编 号 : 0 —05 (0 1 0 0 9 0 1 8 4 7 2 1 ) 3— 18— 5 0
严 俊 , 薛文韬 何 , 跃 王兴梅 钟桂香 程剑 平 , , ,
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( .贵州大学 生命科学学 院, 1 贵州 贵阳 502 ;. 505 2 海法大学 进化研究所 , 以色列 海法 3 贵 州大 学 农 学 院 , 州 贵 阳 5 02 ) . 贵 5 05
摘
要: 二穗短柄草是一种理想的研 究温带禾谷类植物和牧 草的模 式植物。本文对 来源于以 色列 4个不 同地 区
e c s O h H— x a tvte fro ,se a d la at fB.di a h o r w n te n tr lmai o - n e n t e GS P cii so o t tm n e fp rso i s c y n g e i h au a ci t c n t l c
花生壳论文:花生壳中木犀草素的提取分离
花⽣壳论⽂:花⽣壳中⽊犀草素的提取分离花⽣壳论⽂:花⽣壳中⽊犀草素的提取分离【中⽂摘要】花⽣壳中除含有碳⽔化合物和粗纤维物质外,还含有多种黄酮类化合物。
⽊犀草素是其中主要的黄酮类物质,具有抗菌消炎、解痉祛痰、抗氧化、抗肿瘤等多种药理活性。
花⽣壳是⼀种价廉且可再⽣的天然资源,如能提取并分离其中的有效成分⽊犀草素,将该产物⽤于药物或保健⾷品⽣产,具有⼴阔的市场应⽤前景。
本⽂就酶预处理-醇提联合⼯艺,探讨了酶解液pH值、酶解温度、酶解时间、酶⽤量对花⽣壳中黄酮成分⽊犀草素提取效果的影响。
实验结果显⽰,最优酶预处理提取⼯艺条件为:pH值5.4、酶解温度50℃、酶解时间1.5 h、酶⽤量0.10%。
在该最优预处理条件下,⽊犀草素的提取得率达到2.83 mg·g-1。
同时本⽂依据Fick第⼆定律,对醇溶液提取过程建⽴了提取动⼒学模型。
通过实验测得的⽊犀草素提取得率随提取时间变化的数据,推算出速率常数(k)、活化能(Ea)及有效扩散系数(D)等动⼒学参数值,为⽊犀草素的提取⼯艺设计和操作条件的优化提供了⼀定的理论依据。
利⽤柱层析分离纯化技术,研究了聚酰胺树脂对花⽣壳中⽊犀草素静态吸附的热⼒学和动⼒学特征。
实验测得的吸附等温线符合Langmuir吸附等温式,并利⽤热⼒学函数关系式计算得到吸附焓(ΔH)、⾃由能(ΔG)及吸附熵(ΔS),结果表明该吸附过程是⾃发进⾏且伴随放热的物理吸附过程。
同时采⽤拟⼀级反应和拟⼆级反应模型描述了吸附动⼒学数据,得出拟⼆级吸附动⼒学模型能更好地描述聚酰胺树脂对⽊犀草素的吸附⾏为。
另外,通过动态吸附实验测定了穿透曲线,得到聚酰胺树脂对⽊犀草素的动态吸附容量(Q)为0.2817 mg·g-1,总传质系数(KFav)为0.0570 s-1,传质长度(Za)为28.40 cm,为⽊犀草素⽣产的放⼤操作提供了实验和理论依据。
经不同⽐例的醇溶液梯度洗脱分离花⽣壳提取液中的⽊犀草素,确定75%⼄醇溶液洗脱效果最佳。
内侧固定平台单髁置换术治疗膝关节前内侧骨关节炎或自发性骨坏死的近期临床疗效
内侧固定平台单髁置换术治疗膝关节前内侧骨关节炎或自发性骨坏死的近期临床疗效发布时间:2022-01-13T02:31:59.912Z 来源:《世界复合医学》2021年11期作者:刘培明[导读] 目的分析内侧固定平台单髁置换术治疗膝关节前内侧骨关节炎或自发性骨坏死的近期临床疗效。
刘培明哈尔滨市第五医院 150040【摘要】目的分析内侧固定平台单髁置换术治疗膝关节前内侧骨关节炎或自发性骨坏死的近期临床疗效。
方法选取本院2020年3月-11月期间收治的62例膝关节前内侧骨关节炎或自发性骨坏死患者进行回顾性研究,所有患者均实施内侧固定平台单髁置换术进行治疗。
并对治疗前后膝关节功能和影像学结果进行对比。
结果术后患者的V AS、KSS、OKS、ROM、HKA评分优于术前(P<0.05)。
结论对膝关节前内侧骨关节炎或自发性骨坏死患者使用内侧固定平台单髁置换术进行治疗,能够显著改善患者的膝关节功能,值得推广。
【关键词】内侧固定平台单髁置换术;膝关节前内侧骨关节炎;自发性骨坏死;膝关节功能[Abstract] Objective To analyze the short-term clinical effect of medial fixed platform single condylar replacement in the treatment of anteromedial osteoarthritis or spontaneous osteonecrosis of the knee. Methods 62 patients with anteromedial osteoarthritis or spontaneous osteonecrosis of the knee treated in our hospital from March to November 2020 were studied retrospectively. All patients were treated with medial fixed platform single condylar replacement. The knee function and imaging results before and after treatment were compared. Results the scores of vas, KSS, OKs, ROM and HKA after operation were better than those before operation (P < 0.05). Conclusion single condylar replacement with medial fixed platform can significantly improve the knee function of patients with anteromedial osteoarthritis or spontaneous osteonecrosis of the knee, which is worthy of popularization.【 key words 】 medial fixed platform single condylar replacement; Anterior medial osteoarthritis of knee joint; Spontaneous osteonecrosis; Knee function治疗膝关节前内侧骨关节炎或自发性骨坏死患者的阶梯治疗方法是单髁关节置换术,固定平台单髁置换术不会出现无垫片脱位并发症,且和活动平台单髁置换术的效果和假体生存率差不多,临床中越来越广泛的应用【1】。
StochasticProcessesRossSolutionsManual-…
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植物生理学:第三节 水分(亏缺)胁迫及植物的抗旱性
Aerenchyma: continuous, columnar intracellular
spaces formed in root cortical tissues
Aerenchyma development in root cortex of maize after oxygen deprivation. (A) under aerobic conditions, (B) under 72h of hypoxia
• Effect of manipulating ABA concentration in xylem sap on stomatal conductance of leaves (abaxial
epidermis) in maize.
透调节物质(osmolyte) :
高度水溶性、不干预细胞代谢的有机化合物。
• (B) Photographs comparing internode elongation in aerobic ( l e f t ) and submerged (right) plants. Arrows indicate positions of nodes.
During short-term acclimation to anoxic conditions, plants generate ATP through glycolysis and fermentation
Ethylene promotes long-term acclimative
responses:
including formation of aerenchyma and stem
elongation
Treatment
Action
Radial basis functions
λξ φ( x − ξ ),
x ∈ Rn ,
(1.1)
suitable adjustments being made when x is not from the whole space, and the coefficient vector λ = (λξ )ξ∈Ξ is an element of RΞ . In many instances, particularly those that will interest us in Section 3, the interpolation requirements s |Ξ = f |Ξ (1.2) for given data f |Ξ lead to a positive definite interpolation matrix A = {φ( ξ − ζ )}ξ,ζ ∈Ξ . In that case, we call the radial basis function ‘positive definite’ as well. If it is, the linear system of equations that comes from (1.1) and (1.2) and uses precisely that matrix A yields a unique coefficient vector λ ∈ RΞ for the interpolant (1.1). All radial basis functions of Section 3 have this property of positive defin-
1. Introduction
There is a multitude of ways to approximate a function of many variables: multivariate polynomials, splines, tensor product methods, local methods and global methods. All of these approaches have many advantages and some disadvantages, but if the dimensionality of the problem (the number of variables) is large, which is often the case in many applications from statistics to neural networks, our choice of methods is greatly reduced, unless
生物的英语试题及答案
生物的英语试题及答案一、选择题(每题1分,共10分)1. What is the basic unit of life?A. CellB. OrganC. TissueD. System2. Which of the following is not a characteristic of living organisms?A. GrowthB. ReproductionC. RespirationD. Inertia3. What is the process by which plants convert sunlight into energy?A. RespirationB. PhotosynthesisC. FermentationD. Digestion4. Which of the following is a type of genetic mutation?A. Gene duplicationB. Chromosomal deletionC. Both A and BD. None of the above5. What is the term for the study of the relationships among species?A. TaxonomyB. PhylogeneticsC. EcologyD. Ethology6. What is the primary function of the mitochondria in a cell?A. DNA replicationB. Protein synthesisC. Energy productionD. Waste disposal7. Which of the following is a hormone?A. InsulinB. GlucoseC. OxygenD. Carbon dioxide8. What is the correct sequence of the biologicalclassification hierarchy?A. Kingdom, Phylum, Class, Order, Family, Genus, SpeciesB. Species, Genus, Family, Order, Class, Phylum, KingdomC. Kingdom, Species, Genus, Family, Order, Class, PhylumD. Phylum, Class, Order, Family, Species, Genus, Kingdom9. What is the process by which new species arise?A. EvolutionB. Natural selectionC. SpeciationD. All of the above10. What is the role of chlorophyll in photosynthesis?A. To absorb light energyB. To produce waterC. To release oxygenD. To store energy二、填空题(每题1分,共5分)11. The process by which an organism develops from a single cell to a mature individual is called ________.12. The study of the structure of organisms is known as________.13. In genetics, the basic unit of heredity is the ________.14. The largest organ in the human body is the ________.15. The scientific method of classifying organisms based on evolutionary relationships is called ________.三、简答题(每题5分,共10分)16. Explain the role of DNA in the cell.17. Describe the process of cellular respiration.四、论述题(每题15分,共15分)18. Discuss the importance of biodiversity and the threats it faces.答案:一、选择题1-5: A, D, B, C, B6-10: C, A, A, A, A二、填空题11. Development12. Anatomy13. Gene14. Skin15. Phylogenetics三、简答题16. DNA is the molecule that carries the genetic instructions used in the growth, development, functioning, andreproduction of all known living organisms and many viruses.It is the blueprint for the organism's traits and functions. 17. Cellular respiration is the process by which cellsconvert nutrients into energy in the form of ATP (adenosine triphosphate). It involves the breakdown of glucose in the presence of oxygen to produce carbon dioxide, water, and energy.四、论述题18. Biodiversity is crucial for the health of ecosystems, asit ensures the stability and resilience of these systems. It provides a variety of ecosystem services such as pollination, pest control, and nutrient cycling. Threats to biodiversity include habitat destruction, climate change, overexploitation, pollution, and the introduction of invasive species.结束语:通过这份生物英语试题及答案,我们不仅复习了生物学的基本概念和过程,还加深了对生物多样性重要性及其面临的挑战的理解。
On the asymptotic expansion of the solutions of the separated nonlinear Schroedinger equati
a r X i v :n l i n /0012025v 3 [n l i n .S I ] 10 M a y 2001On the Asymptotic Expansion of the Solutions of the Separated Nonlinear Schr¨o dinger EquationA.A.Kapaev,St Petersburg Department of Steklov Mathematical Institute,Fontanka 27,St Petersburg 191011,Russia,V.E.Korepin,C.N.Yang Institute for Theoretical Physics,State University of New York at Stony Brook,Stony Brook,NY 11794-3840,USAAbstractNonlinear Schr¨o dinger equation with the Schwarzian initial data is important in nonlinear optics,Bose condensation and in the theory of strongly correlated electrons.The asymptotic solutions in the region x/t =O (1),t →∞,can be represented as a double series in t −1and ln t .Our current purpose is the description of the asymptotics of the coefficients of the series.MSC 35A20,35C20,35G20Keywords:integrable PDE,long time asymptotics,asymptotic expansion1IntroductionA coupled nonlinear dispersive partial differential equation in (1+1)dimension for the functions g +and g −,−i∂t g +=12∂2x g −+4g 2−g +,(1)called the separated Nonlinear Schr¨o dinger equation (sNLS),contains the con-ventional NLS equation in both the focusing and defocusing forms as g +=¯g −or g +=−¯g −,respectively.For certain physical applications,e.g.in nonlin-ear optics,Bose condensation,theory of strongly correlated electrons,see [1]–[9],the detailed information on the long time asymptotics of solutions with initial conditions rapidly decaying as x →±∞is quite useful for qualitative explanation of the experimental phenomena.Our interest to the long time asymptotics for the sNLS equation is inspired by its application to the Hubbard model for one-dimensional gas of strongly correlated electrons.The model explains a remarkable effect of charge and spin separation,discovered experimentally by C.Kim,Z.-X.M.Shen,N.Motoyama,H.Eisaki,hida,T.Tohyama and S.Maekawa [19].Theoretical justification1of the charge and spin separation include the study of temperature dependent correlation functions in the Hubbard model.In the papers[1]–[3],it was proven that time and temperature dependent correlations in Hubbard model can be described by the sNLS equation(1).For the systems completely integrable in the sense of the Lax representa-tion[10,11],the necessary asymptotic information can be extracted from the Riemann-Hilbert problem analysis[12].Often,the fact of integrability implies the existence of a long time expansion of the generic solution in a formal series, the successive terms of which satisfy some recurrence relation,and the leading order coefficients can be expressed in terms of the spectral data for the associ-ated linear system.For equation(1),the Lax pair was discovered in[13],while the formulation of the Riemann-Hilbert problem can be found in[8].As t→∞for x/t bounded,system(1)admits the formal solution given byg+=e i x22+iν)ln4t u0+∞ n=12n k=0(ln4t)k2t −(1t nv nk ,(2)where the quantitiesν,u0,v0,u nk and v nk are some functions ofλ0=−x/2t.For the NLS equation(g+=±¯g−),the asymptotic expansion was suggested by M.Ablowitz and H.Segur[6].For the defocusing NLS(g+=−¯g−),the existence of the asymptotic series(2)is proven by P.Deift and X.Zhou[9] using the Riemann-Hilbert problem analysis,and there is no principal obstacle to extend their approach for the case of the separated NLS equation.Thus we refer to(2)as the Ablowitz-Segur-Deift-Zhou expansion.Expressions for the leading coefficients for the asymptotic expansion of the conventional NLS equation in terms of the spectral data were found by S.Manakov,V.Zakharov, H.Segur and M.Ablowitz,see[14]–[16].The general sNLS case was studied by A.Its,A.Izergin,V.Korepin and G.Varzugin[17],who have expressed the leading order coefficients u0,v0andν=−u0v0in(2)in terms of the spectral data.The generic solution of the focusing NLS equation contains solitons and radiation.The interaction of the single soliton with the radiation was described by Segur[18].It can be shown that,for the generic Schwarzian initial data and generic bounded ratio x/t,|c−xthese coefficients as well as for u n,2n−1,v n,2n−1,wefind simple exact formulaeu n,2n=u0i n(ν′)2n8n n!,(3)and(20)below.We describe coefficients at other powers of ln t using the gener-ating functions which can be reduced to a system of polynomials satisfying the recursion relations,see(24),(23).As a by-product,we modify the Ablowitz-Segur-Deift-Zhou expansion(2),g+=exp i x22+iν)ln4t+i(ν′)2ln24t2] k=0(ln4t)k2t −(18t∞n=02n−[n+1t n˜v n,k.(4)2Recurrence relations and generating functions Substituting(2)into(1),and equating coefficients of t−1,wefindν=−u0v0.(5) In the order t−n,n≥2,equating coefficients of ln j4t,0≤j≤2n,we obtain the recursion−i(j+1)u n,j+1+inu n,j=νu n,j−iν′′8u n−1,j−2−−iν′8u′′n−1,j+nl,k,m=0l+k+m=nα=0, (2)β=0, (2)γ=0, (2)α+β+γ=ju l,αu k,βv m,γ,(6) i(j+1)v n,j+1−inv n,j=νv n,j+iν′′8v n−1,j−2++iν′8v′′n−1,j+nl,k,m=0l+k+m=nα=0, (2)β=0, (2)γ=0, (2)α+β+γ=ju l,αv k,βv m,γ,(7)where the prime means differentiation with respect toλ0=−x/(2t).Master generating functions F(z,ζ),G(z,ζ)for the coefficients u n,k,v n,k are defined by the formal seriesF(z,ζ)= n,k u n,k z nζk,G(z,ζ)= n,k v n,k z nζk,(8)3where the coefficients u n,k,v n,k vanish for n<0,k<0and k>2n.It is straightforward to check that the master generating functions satisfy the nonstationary separated Nonlinear Schr¨o dinger equation in(1+2)dimensions,−iFζ+izF z= ν−iν′′8zζ2 F−iν′8zF′′+F2G,iGζ−izG z= ν+iν′′8zζ2 G+iν′8zG′′+F G2.(9) We also consider the sectional generating functions f j(z),g j(z),j≥0,f j(z)=∞n=0u n,2n−j z n,g j(z)=∞n=0v n,2n−j z n.(10)Note,f j(z)≡g j(z)≡0for j<0because u n,k=v n,k=0for k>2n.The master generating functions F,G and the sectional generating functions f j,g j are related by the equationsF(zζ−2,ζ)=∞j=0ζ−j f j(z),G(zζ−2,ζ)=∞j=0ζ−j g j(z).(11)Using(11)in(9)and equating coefficients ofζ−j,we obtain the differential system for the sectional generating functions f j(z),g j(z),−2iz∂z f j−1+i(j−1)f j−1+iz∂z f j==νf j−z iν′′8f j−ziν′8f′′j−2+jk,l,m=0k+l+m=jf k f lg m,2iz∂z g j−1−i(j−1)g j−1−iz∂z g j=(12)=νg j+z iν′′8g j+ziν′8g′′j−2+jk,l,m=0k+l+m=jf kg l g m.Thus,the generating functions f0(z),g0(z)for u n,2n,v n,2n solve the systemiz∂z f0=νf0−z (ν′)28g0+f0g20.(13)The system implies that the product f0(z)g0(z)≡const.Since f0(0)=u0and g0(0)=v0,we obtain the identityf0g0(z)=−ν.(14) Using(14)in(13),we easilyfindf0(z)=u0e i(ν′)28n n!z n,4g0(z)=v0e−i(ν′)28n n!z n,(15)which yield the explicit expressions(3)for the coefficients u n,2n,v n,2n.Generating functions f1(z),g1(z)for u n,2n−1,v n,2n−1,satisfy the differential system−2iz∂z f0+iz∂z f1=νf1−z iν′′8f1−ziν′8g0−z(ν′)24g′0+f1g20+2f0g0g1.(16)We will show that the differential system(16)for f1(z)and g1(z)is solvable in terms of elementary functions.First,let us introduce the auxiliary functionsp1(z)=f1(z)g0(z).These functions satisfy the non-homogeneous system of linear ODEs∂z p1=iν4−ν′′4f′0z(p1+q1)−i(ν′)28−ν′g0,(17)so that∂z(q1+p1)=−(ν2)′′8z,p1(z)= −iνν′′8−ν′u′032z2,g1(z)=q1(z)g0(z),g0(z)=v0e−i(ν′)24−ν′′4v0 z+i(ν′)2ν′′4−ν′′4u0 ,v1,1=v0 iνν′′8−ν′v′0u n,2n −1=−2u 0i n −1(ν′)2(n −1)n −1ν′′u 0,n ≥2,v n,2n −1=−2v 0(−i )n −1(ν′)2(n −1)n −1ν′′v 0,n ≥2.Generating functions f j (z ),g j (z )for u n,2n −j ,v n,2n −j ,j ≥2,satisfy the differential system (12).Similarly to the case j =1above,let us introduce the auxiliary functions p j and q j ,p j =f jg 0.(21)In the terms of these functions,the system (12)reads,∂z p j =iνz(p j +q j )+b j ,(22)wherea j =2∂z p j −1+i (ν′)28−j −14(p j −1f 0)′8f 0+iν4−ν′′zq j −1−−ν′g 0+i(q j −2g 0)′′zj −1 k,l,m =0k +l +m =jp k q l q m .(23)With the initial condition p j (0)=q j (0)=0,the system is easily integrated and uniquely determines the functions p j (z ),q j (z ),p j (z )= z 0a j (ζ)dζ+iνzdζζζdξ(a j (ξ)+b j (ξ)).(24)These equations with expressions (23)together establish the recursion relationfor the functions p j (z ),q j (z ).In terms of p j (z )and q j (z ),expansion (2)readsg +=ei x22+iν)ln 4t +i(ν′)2ln 24tt2t−(18tv 0∞ j =0q j ln 24tln j 4t.(25)6Let a j (z )and b j (z )be polynomials of degree M with the zero z =0of multiplicity m ,a j (z )=M k =ma jk z k,b j (z )=Mk =mb jk z k .Then the functions p j (z )and q j (z )(24)arepolynomials of degree M +1witha zero at z =0of multiplicity m +1,p j (z )=M +1k =m +11k(a j,k −1+b j,k −1)z k ,q j (z )=M +1k =m +11k(a j,k −1+b j,k −1) z k.(26)On the other hand,a j (z )and b j (z )are described in (23)as the actions of the differential operators applied to the functions p j ′,q j ′with j ′<j .Because p 0(z )=q 0(z )≡1and p 1(z ),q 1(z )are polynomials of the second degree and a single zero at z =0,cf.(19),it easy to check that a 2(z )and b 2(z )are non-homogeneous polynomials of the third degree such thata 2,3=−(ν′)4(ν′′)2210(2+iν),(27)a 2,0=−iνν′′8−ν′u ′08u 0,b 2,0=iνν′′8−ν′v ′08v 0.Thus p 2(z )and q 2(z )are polynomials of the fourth degree with a single zero at z =0.Some of their coefficients arep 2,4=q 2,4=−(ν′)4(ν′′)24−(1+2iν)ν′′8u 0−ν(u ′0)24−(1−2iν)ν′′8v 0−ν(v ′0)22.Proof .The assertion holds true for j =0,1,2.Let it be correct for ∀j <j ′.Then a j ′(z )and b j ′(z )are defined as the sum of polynomials.The maximal de-grees of such polynomials are deg (p j ′−1f 0)′/f 0 =2j ′−1,deg (q j ′−1g 0)′/g 0 =72j′−1,anddeg 1z j′−1 α,β,γ=0α+β+γ=j′pαqβqγ =2j′−1. Thus deg a j′(z)=deg b j′(z)≤2j′−1,and deg p j′(z)=deg q j′(z)≤2j′.Multiplicity of the zero at z=0of a j′(z)and b j′(z)is no less than the min-imal multiplicity of the summed polynomials in(23),but the minor coefficients of the polynomials2∂z p j′−1and−(j−1)p j′−1/z,as well as of2∂z q j′−1and −(j−1)q j′−1/z may cancel each other.Let j′=2k be even.Thenm j′=min m j′−1;m j′−2+1;minα,β,γ=0,...,j′−1α+β+γ=j′mα+mβ+mγ =j′2 . Let j′=2k−1be odd.Then2m j′−1−(j′−1)=0,andm j′=min m j′−1+1;m j′−2+1;minα,β,γ=0,...,j′−1α+β+γ=j′mα+mβ+mγ =j′+12]p j,k z k,q j(z)=2jk=[j+12]z nn−[j+18k k!,g j(z)=v0∞n=[j+12]k=max{0;n−2j}q j,n−k(−i)k(ν′)2k2]k=max{0;n−2j}p j,n−ki k(ν′)2k2]k=max{0;n−2j}q j,n−k(−i)k(ν′)2kIn particular,the leading asymptotic term of these coefficients as n→∞and j fixed is given byu n,2n−j=u0p j,2j i n−2j(ν′)2(n−2j)n) ,v n,2n−j=v0q j,2j (−i)n−2j(ν′)2(n−2j)n) .(32)Thus we have reduced the problem of the evaluation of the asymptotics of the coefficients u n,2n−j v n,2n−j for large n to the computation of the leading coefficients of the polynomials p j(z),q j(z).In fact,using(24)or(26)and(23), it can be shown that the coefficients p j,2j,q j,2j satisfy the recurrence relationsp j,2j=−i (ν′)2ν′′2jj−1k,l,m=0k+l+m=jp k,2k p l,2l q m,2m++ν(ν′)2ν′′4j2j−1k,l,m=0k+l+m=jp k,2k(p l,2l−q l,2l)q m,2m,q j,2j=i (ν′)2ν′′2jj−1k,l,m=0k+l+m=jp k,2k q l,2l q m,2m−(33)−ν(ν′)2ν′′4j2j−1k,l,m=0k+l+m=jp k,2k(p l,2l−q l,2l)q m,2m.Similarly,the coefficients u n,0,v n,0for the non-logarithmic terms appears from(31)for j=2n,and are given simply byu n,0=u0p2n,n,v n,0=v0q2n,n.(34) Thus the problem of evaluation of the asymptotics of the coefficients u n,0,v n,0 for n large is equivalent to computation of the asymptotics of the minor coeffi-cients in the polynomials p j(z),q j(z).However,the last problem does not allow a straightforward solution because,according to(8),the sectional generating functions for the coefficients u n,0,v n,0are given byF(z,0)=∞n=0u n,0z n,G(z,0)=∞n=0v n,0z n,and solve the separated Nonlinear Schr¨o dinger equation−iFζ+izF z=νF+18zG′′+F G2.(35)93DiscussionOur consideration based on the use of generating functions of different types reveals the asymptotic behavior of the coefficients u n,2n−j,v n,2n−j as n→∞and jfixed for the long time asymptotic expansion(2)of the generic solution of the sNLS equation(1).The leading order dependence of these coefficients on n is described by the ratio a n2+d).The investigation of theRiemann-Hilbert problem for the sNLS equation yielding this estimate will be published elsewhere.Acknowledgments.We are grateful to the support of NSF Grant PHY-9988566.We also express our gratitude to P.Deift,A.Its and X.Zhou for discussions.A.K.was partially supported by the Russian Foundation for Basic Research under grant99-01-00687.He is also grateful to the staffof C.N.Yang Institute for Theoretical Physics of the State University of New York at Stony Brook for hospitality during his visit when this work was done. References[1]F.G¨o hmann,V.E.Korepin,Phys.Lett.A260(1999)516.[2]F.G¨o hmann,A.R.Its,V.E.Korepin,Phys.Lett.A249(1998)117.[3]F.G¨o hmann,A.G.Izergin,V.E.Korepin,A.G.Pronko,Int.J.Modern Phys.B12no.23(1998)2409.[4]V.E.Zakharov,S.V.Manakov,S.P.Novikov,L.P.Pitaevskiy,Soli-ton theory.Inverse scattering transform method,Moscow,Nauka,1980.[5]F.Calogero,A.Degasperis,Spectral transforms and solitons:toolsto solve and investigate nonlinear evolution equations,Amsterdam-New York-Oxford,1980.[6]M.J.Ablowitz,H.Segur,Solitons and the inverse scattering trans-form,SIAM,Philadelphia,1981.10[7]R.K.Dodd,J.C.Eilbeck,J.D.Gibbon,H.C.Morris,Solitons andnonlinear wave equations,Academic Press,London-Orlando-San Diego-New York-Toronto-Montreal-Sydney-Tokyo,1982.[8]L.D.Faddeev,L.A.Takhtajan,Hamiltonian Approach to the Soli-ton Theory,Nauka,Moscow,1986.[9]P.Deift,X.Zhou,Comm.Math.Phys.165(1995)175.[10]C.S.Gardner,J.M.Greene,M.D.Kruskal,R.M.Miura,Phys.Rev.Lett.19(1967)1095.[11]x,Comm.Pure Appl.Math.21(1968)467.[12]V.E.Zakharov,A.B.Shabat,Funkts.Analiz Prilozh.13(1979)13.[13]V.E.Zakharov,A.B.Shabat,JETP61(1971)118.[14]S.V.Manakov,JETP65(1973)505.[15]V.E.Zakharov,S.V.Manakov,JETP71(1973)203.[16]H.Segur,M.J.Ablowitz,J.Math.Phys.17(1976)710.[17]A.R.Its,A.G.Izergin,V.E.Korepin,G.G.Varzugin,Physica D54(1992)351.[18]H.Segur,J.Math.Phys.17(1976)714.[19]C.Kim,Z.-X.M.Shen,N.Motoyama,H.Eisaki,hida,T.To-hyama and S.Maekawa Phys Rev Lett.82(1999)802[20]A.R.Its,SR Izvestiya26(1986)497.11。
First-principles study of the structural, vibrational, phonon and thermodynamic
1. Introduction Ultra-high temperature ceramics (UHTCs) with melting temperatures in excess of 3000 K are usually composed by the refractory borides, carbides and nitrides of early transition metals [1–7]. Among the UHTCs, transition metal carbides (TMC) such as TiC, ZrC and HfC are metallic compounds with unique physical and chemical properties including an extremely high melting point and hardness, chemical stability, corrosion resistance combined with metallic electrical and thermal conductivities [5–10]. These features give transition metal carbides the capability to withstand high temperatures in oxidizing environments, making them candidates for applications in the atmosphere of extreme thermal and chemical environments [6,7]. The structural, vibrational, phonon and thermodynamic properties of IVb group transition metal carbides have been investigated experimentally [10–17] and theoretically [13,18–28] in the earlier reports. In the 1970s, the phonon dispersion relations of TiC, ZrC and HfC were measured using inelastic neutron scattering by Pintschovius et al. [10] and Smith et al. [15–17]. Lattice dynamics calculation and the phonon dispersion relations of transition metal carbides such as ZrC and HfC were reported using a phenomenological ‘‘double-shell’’ model theory [18] where long-range interatomic interactions were taken into account in order to get a
托莫西丁中间体的分离
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含量为 2 6 。随后 , 吸附了杂质 和未反应 完的 . 将 原料硅胶用无水乙醇浸泡 , 过滤 , 回收未反应完的原 料 。主产品含量 5 以上 。 O
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用于治疗心力衰竭的二硫化物环状多肽[发明专利]
专利名称:用于治疗心力衰竭的二硫化物环状多肽专利类型:发明专利
发明人:F·泽克里,P·格罗舍,八十岛华杨,H·赵,J·袁申请号:CN201480052701.8
申请日:20140721
公开号:CN105612174A
公开日:
20160525
专利内容由知识产权出版社提供
摘要:本发明提供了式Iˊ的合成多肽:X1-R-P-R-X5-X6-X7-K-X9-P-X11-X12-X13或其酰胺、酯、盐或其生物缀合物,其中X1、X5、X6、X7、X9和X11至X13如本文定义。
该多肽和生物缀合物是APJ受体的激动剂。
本发明还涉及制备本发明的多肽或生物缀合物的方法,及其治疗用途,诸如治疗或预防急性代偿失调性心力衰竭(ADHF)、慢性心力衰竭、肺性高血压、心房颤动、布鲁格达氏综合征、室性心动过速、动脉粥样硬化、高血压、再狭窄、局部缺血性心血管疾病、心肌病、心脏纤维化、心律不齐、水潴留、糖尿病(包括妊娠糖尿病)、肥胖症、外周动脉病、脑血管意外、暂时性缺血发作、创伤性脑损伤、肌萎缩侧索硬化、灼伤(包括晒伤)及先兆子痫。
本发明还提供了药理学活性剂的组合以及药物组合物。
申请人:诺华股份有限公司
地址:瑞士巴塞尔
国籍:CH
代理机构:北京市中咨律师事务所
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短程分子蒸馏的英文
短程分子蒸馏的英文Short-Path Molecular Distillation.Introduction.Molecular distillation, often referred to as short-path distillation, is a highly specialized and efficient separation technique used in various industries,particularly in the field of chemicals and pharmaceuticals. This technique differs from traditional distillation methods in its ability to separate components based ontheir molecular weight and volatility rather than boiling points. Short-path molecular distillation is named such because it employs a shorter path for vaporization, which results in faster separation and higher purity products.Working Principles.The working principle of short-path moleculardistillation lies in the utilization of vacuum and hightemperatures to separate components of a mixture. The feed material is heated to a temperature slightly below its boiling point, and the resulting vapors are directed through a short column or path. This short path ensures rapid vaporization and subsequent condensation of the volatile components. The vapors are then condensed and collected as the desired product, while the residual material is further processed or discarded.Applications.Short-path molecular distillation finds widespread application in various industries:1. Pharmaceutical Industry: It is used for purifying and isolating active pharmaceutical ingredients (APIs) and for removing impurities from drugs.2. Food Industry: It is employed in the purification of oils, fats, and essential oils, as well as for the fractionation of fats and the removal of unwanted compounds from food products.3. Cosmetics Industry: Molecular distillation is usedto extract pure and concentrated essential oils, fragrances, and active ingredients for use in cosmetics and personal care products.4. Petrochemical Industry: It is used for separatingand purifying hydrocarbons and other petrochemical compounds.Advantages of Short-Path Molecular Distillation.1. High Purity Products: Short-path distillation allows for the separation of components with high purity, makingit suitable for applications that require high-quality products.2. Low Operating Costs: The short path and efficient vaporization process result in reduced energy consumption and lower operating costs.3. Flexible Operation: Short-path distillation can beoperated under a wide range of temperatures and pressures, allowing for the separation of a variety of materials.4. Scalability: This technology can be scaled up or down to meet different production requirements, making it suitable for both small-scale and industrial-scale operations.Challenges and Limitations.1. Equipment Cost: While the operating costs are low, the initial investment in short-path distillation equipment can be relatively high.2. Material Compatibility: Some materials may not be suitable for short-path distillation due to their chemical properties or thermal stability.3. Operator Expertise: The process requires operators with specific knowledge and expertise to ensure optimal performance and product quality.Conclusion.Short-path molecular distillation is a highly effective and efficient separation technique that offers numerous advantages over traditional distillation methods. Itsability to produce high-purity products with low operating costs makes it a valuable tool in various industries, including pharmaceuticals, food processing, cosmetics, and petrochemicals. However, like any other technology, it also has its challenges and limitations, which need to be carefully considered during its application.。
氮气吸脱附曲线英语
氮气吸脱附曲线英语Here's a sample text written in English, following the given requirements:Okay, let's talk about the nitrogen adsorption-desorption curve. It's basically a graph that shows how nitrogen molecules interact with a solid surface. You know, when you expose a material to nitrogen gas, it starts adsorbing the gas molecules on its surface. And when you change the pressure or temperature, those molecules can desorb back into the gas phase.Now, this curve is really useful in understanding the porous structure of materials. Like, if you see a steeprise at low pressures, that usually means there are lots of micropores in the material. And the plateau region at higher pressures tells you about the mesopores and macropores.But here's the cool part: the shape of the curve canalso reveal the type of interaction between the nitrogen and the material. Like, if the desorption curve doesn't follow the same path as the adsorption curve, that suggests some sort of interaction between the gas and the solid.And speaking of interactions, did you know that the nitrogen adsorption-desorption curve can also be used to calculate the surface area of a material? Yeah, it's pretty amazing. By measuring the amount of nitrogen adsorbed at different pressures, you can estimate the total surface area of the material, even down to the nanometer scale.So in a nutshell, this curve is a powerful tool for characterizing porous materials. It gives you insights into their pore structure, surface area, and even the nature of interactions between the solid and the gas. And all this from just a simple graph!。
可伸缩的植物用可穿戴设备和无人机投放的智能标签
可伸缩的植物用可穿戴设备和无人机投放的智能标签
可伸缩的植物用可穿戴设备和无人机投放的智能标签,其目的是帮助农业向大数据化方向改造。
大规模地对植株进行监测的技术在成本上已经变得相对便宜,从2019年开始,将在三个国家的大型温室或农田中对有关技术进行现场试验。
这一想法来自沙特阿拉伯阿卜杜拉国王科技大学(KAUST)的一些研究人员,他们拥有柔性电子技术方面的专业知识。
与在温室中培育基因工程植物的同事交谈之后,他们认识到需要可大规模部署并能报告每株植物的情况的便宜传感器。
他们早期的产品包括用于测量植物生长过程中的微米级变化的可伸缩传感器以及可通过无人机投放、在空中螺旋式下降而落到植物上去的“PlantCopter”温度和湿度传感器。
KAUST电气工程教授Muhammad Mustafa Hussain说:“得益于其设计架构,在部署PlantCopter时,它们会战略性地附着到植物的叶子上。
很显然,并不是每一个PlantCopter都能附着到植物上,但考虑到它们的低成本,非100%的附着率也还是可以接受的。
”
Hussain及其同事们的愿景是通过便宜的生物可降解材料和低功耗的蓝牙。
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a rX iv:mat h /612313v1[mat h.PR]12Dec26Free-Knot Spline Approximation of Stochastic Processes Jakob Creutzig ∗Thomas M¨u ller-Gronbach †Klaus Ritter ∗Dedicated to Henryk Wo ´z niakowski on the occasion of his 60th birthday December 6,2006Abstract We study optimal approximation of stochastic processes by polynomial splines with free knots.The number of free knots is either a priori fixed or may depend on the particular trajectory.For the s -fold integrated Wiener process as well as for scalar diffusion processes we determine the asymptotic behavior of the average L p -distance to the splines spaces,as the (expected)number k of free knots tends to infinity.Keywords:Integrated Wiener process,diffusion process,stochastic dif-ferential equation,optimal spline approximation,free knots 1Introduction Consider a stochastic process X =(X (t ))t ≥0with continuous paths on a proba-bility space (Ω,A ,P ).We study optimal approximation of X on the unit interval by polynomial splines with free knots,which has first been treated in [10].For k ∈N and r ∈N 0we let Πr denote the set of polynomials of degree at most r ,and we consider the space Φk,r of polynomial splinesϕ=kj =11]t j −1,t j ]·πj ,where 0=t 0<...<t k =1and π1,...,πk ∈Πr .Furthermore,for 1≤p ≤∞and 1≤q <∞we let N k,r denote the class of measurable mappingsX :Ω→Φk,rwithΦk,r being considered as a subset of L p[0,1],and we definee k,r(X,L p,q)=inf E X− X q L p[0,1] 1/q: X∈N k,r .This quantity is an average L p-distance from X to the spaceΦk,r.A natural extension of this methodology is not to work with an a priori chosen number of free knots,but only to control the average number of knots needed.This leads to the definitionΦr= ∞k=1Φk,r and to the study of the class N r of measurable mappingsX:Ω→ΦrwithΦr being considered as a subset of L p[0,1].For a spline approximation method X∈N r we defineζ( X)=E(min{k∈N: X(·)∈Φk,r}),i.e.,ζ( X)−1is the expected number of free knots used by X.Subject to the boundζ( X)≤k,the minimal achievable error for approximation of X in the class N r is given bye av k,r(X,L p,q)=inf E X− X q L p[0,1] 1/q: X∈N r,ζ( X)≤k . We shall study the asymptotics of the quantities e k,r and e av k,r as k tends to infinity.The spline spacesΦk,r form nonlinear manifolds that consist of k-term linear combinations of functions of the form1]t,1]·πwith0≤t<1andπ∈Πr. Hence we are addressing a so-called nonlinear approximation problem.While nonlinear approximation is extensively studied for deterministic functions,see [7]for a survey,much less is known for stochastic processes,i.e.,for random functions.Here we refer to[2,3],where wavelet methods are analyzed,and to [10].In the latter paper nonlinear approximation is related to approximation based on partial information,as studied in information-based complexity,and spline approximation with free knots is analyzed as a particular instance.2Main ResultsFor two sequences(a k)k∈N and(b k)k∈N of positive real numbers we write a k≈b k if lim k→∞a k/b k=1,and a k b k if lim inf k→∞a k/b k≥1.Additionally, a k≍b k means c1≤a k/b k≤c2for all k∈N and some positive constants c i.Fix s∈N0and let W(s)denote an s-fold integrated Wiener process.In[10], the following result was proved.Theorem1.For r∈N0with r≥s,e k,r(W(s),L∞,1)≍e av k,r(W(s),L∞,1)≍k−(s+1/2).2Ourfirst result refines and extends this theorem.Consider the stopping time τr,s,p=inf t>0:infπ∈Πr W(s)−π L p[0,t]>1 ,which yields the length of the maximal subinterval[0,τr,s,p]that permits best approximation of W(s)fromΠr with error at most one.We have0<Eτr,s,p<∞,and we putβ=s+1/2+1/pas well asc r,s,p=(Eτr,s,p)−βandb s,p=(s+1/2)s+1/2·p−1/p·β−β.Theorem2.Let r∈N0with r≥s and1≤q<∞.Then,for p=∞,e av k,r(W(s),L∞,q)≈e k,r(W(s),L∞,q)≈c r,s,∞·k−(s+1/2).(1) Furthermore,for1≤p<∞,b s,p·c r,s,p·k−(s+1/2) e k,r(W(s),L p,q) c r,s,p·k−(s+1/2)(2) ande av k,r(W(s),L p,q)≍k−(s+1/2).(3)Note that the bounds provided by(1)and(2)do not depend on the averaging parameter q.In particular,asymptotic constants cannot explode for q tending to infinity.Furthermore,b s,p=1limp→∞for every s∈N,butlimb s,p=0s→∞for every1≤p<∞.We conjecture that the upper bound in(i)is sharp. We have an explicit construction of methods X∗k∈N k,r that achieve the upper bounds in(1)and(2),i.e.,E W(s)− X∗k q L p[0,1] 1/q≈c r,s,p·k−(s+1/2),(4) see(10).Moreover,these methods a.s.satisfyW(s)− X∗k L p[0,1]≈c r,s,p·k−(s+1/2)(5) as well,whileW(s)− X k L p[0,1] b s,p·c r,s,p·k−(s+1/2)(6) holds a.s.for every sequence of approximations X k∈N k,r.Here,b s,∞=1.3Our second result deals with approximation of a scalar diffusion process given by the stochastic differential equationdX(t)=a(X(t))dt+b(X(t))dW(t),t≥0,X(0)=x0.(7)Here x0∈R,and W denotes a one-dimensional Wiener process.Moreover,we assume that the functions a,b:R→R satisfy(A1)a is Lipschitz continuous,(A2)b is differentiable with a bounded and Lipschitz continuous derivative,(A3)b(x0)=0.Theorem3.Let r∈N0,1≤q<∞,and1≤p≤∞.Thene k,r(X,L p,q)≍e av k,r(X,L p,q)≍k−1/2holds for the strong solution X of equation(7).For a diffusion process X piecewise linear interpolation with free knots is fre-quently used in connection with adaptive step-size control.Theorem3provides a lower bound for the L p-error of any such numerical algorithm,no matter whether just Wiener increments or,e.g.,arbitrary multiple Itˆo-integrals are used.Error estimates in[8,16]lead to refined upper bounds in Theorem3for the case1≤p<∞,as follows.Putκ(p1,p2)= E b◦X p2L p1[0,1] 1/p2for1≤p1,p2<∞.Furthermore,let B denote a Brownian bridge on[0,1]and defineη(p)= E B p L p[0,1] 1/p.Thene k,1(X,L p,p) η(p)·κ(2p/(p+2),p)·k−1/2ande av k,1(X,L p,p) η(p)·κ(2p/(p+2),2p/(p+2))·k−1/2.We add that these upper bounds are achieved by numerical algorithms with adaptive step-size control for the Wiener increments.In the case p=∞it is interesting to compare the results on free-knot spline approximation with average k-widths of X.The latter quantities are defined byd k(X,L p,q)=infΦ E infϕ∈Φ X−ϕ q L p[0,1] 1/q,where the infimum is taken over all linear subspacesΦ⊆L p[0,1]of dimension at most k.For X=W(s)as well as in the diffusion case we haved k(X,L∞,q)≍k−(s+1/2),4see[4,13,14,15]and[6].Almost optimal linear subspaces are not known ex-plicitly,since the proof of the upper bound for d k(X,L∞,q)is non-constructive. We add that in the case of an s-fold integrated Wiener process piecewise poly-nomial interpolation of W(s)at equidistant knots i/k only yields errors of order (ln k)1/2·k−(s+1/2),see[19]for results and references.Similarly,in the diffusion case,methods X k∈N r that are only based on pointwise evaluation of W and satisfyζ( X k)≤k can at most achieve errors of order(ln k)1/2·k−1/2,see[17]. 3Approximation of Deterministic FunctionsLet r∈N0and1≤p≤∞befixed.We introduce error measures,which allow to determine suitable free knots for spline approximation.For f∈C[0,∞[and 0≤u<v we putδ[u,v](f)=infπ∈Πr f−π Lp[u,v].Furthermore,forε>0,we putτ0,ε(f)=0,and we defineτj,ε(f)=inf{t>τj−1,ε(f):δ[τj−1,ε(f),t](f)>ε}for j≥1.Here inf∅=∞,as usual.Put I j(f)={ε>0:τj,ε(f)<∞}. Lemma4.Let j∈N.(i)Ifε∈I j(f)thenδ[τj−1,ε(f),τj,ε(f)](f)=ε.(ii)The set I j(f)is an interval,and the mappingε→τj,ε(f)is strictly in-creasing and right-continuous on I j(f).Furthermore,τj,ε(f)>τj−1,ε(f) ifε∈I j−1(f),and limε→∞τj,ε(f)=∞.(iii)If v→δ[u,v](f)is strictly increasing for every u≥0,thenε→τj,ε(f)is continuous on I j(f).Proof.First we show that the mapping(u,v)→δ[u,v](f)is continuous.Put J1=[u/2,u+(v−u)/3]as well as J2=[v−(v−u)/3,2v].Moreover,let πα(t)= r i=0αi·t i forα∈R r+1,and define a norm on R r+1byα = πα Lp[u+(v−u)/3,v−(v−u)/3].If(x,y)∈J1×J2andf−πα Lp[x,y]=δ[x,y](f)thenα ≤ πα Lp[x,y]≤δ[u/2,2v](f)+ f Lp[u/2,2v].Hence there exists a compact set K⊆R r+1such thatδ[x,y](f)=infα∈K f−πα Lp[x,y]5for every(x,y)∈J1×J2.Since(x,y,α)→ f−πα Lp[x,y]defines a continuousmapping on J1×J2×K,we conclude that(x,y)→infα∈K f−πα Lp[x,y]iscontinuous,too,on J1×J2.Continuity and monotonicity of v→δ[u,v](f)immediately imply(i).The monotonicity stated in(ii)will be verified inductively.Let0<ε1<ε2withε2∈I j(f),and suppose thatτj−1,ε1(f)≤τj−1,ε2(f).Note that the latterholds true by definition for j=1.From(i)we getδ[τj−1,ε1(f),τj,ε2(f)](f)≥δ[τj−1,ε2(f),τj,ε2(f)](f)=ε2.This impliesτj,ε1(f)≤τj,ε2(f),and(i)excludes equality to hold here.Sinceδ[u,v](f)≤ f Lp[u,v],the mappingsε→τj,ε(f)are unbounded andτj,ε(f)>τj−1,ε(f)ifε∈I j−1(f).For the proof of the continuity properties stated in(ii)and(iii)we also proceed inductively,and we use(i)and the monotonicity from(ii).Consider a sequence(εn)n∈N in I j(f),which converges monotonically toε∈I j(f),andput t=lim n→∞τj,εn (f).Assume that lim n→∞τj−1,εn(f)=τj−1,ε(f),whichobviously holds true for j=1.Continuity of(u,v)→δ[u,v](f)and(i)implyδ[τj−1,ε(f),t](f)=ε,so that t≤τj,ε(f).For a decreasing sequence(εn)n∈N wealso haveτj,ε(f)≤t.For an increasing sequence(εn)n∈N we use the strict monotonicity of v→δ[u,v](f)to derive t=τj,ε(f).Let F denote the class of functions f∈C[0,∞[that satisfyτj,ε(f)<∞(8) for every j∈N andε>0as well aslimε→0τj,ε(f)=0(9) for every j∈N.Let k∈N.We now present an almost optimal spline approximation method of degree r with k−1free knots for functions f∈F.Putγk(f)=inf{ε>0:τk,ε(f)≥1}and note that(9)together with Lemma4.(ii)impliesγk(f)∈]0,∞[.Letτj=τj,γk (f)(f)for j=0,...,k and defineϕ∗k(f)=kj=11]τj−1,τj]·argminπ∈Πr f−π L p[τj−1,τj].(10)Note that Lemma4guaranteesf−ϕ∗k(f) Lp[τj−1,τj]=γk(f)(11) for j=1,...,k andτk≥1.(12) The splineϕ∗k(f)|[0,1]∈Φk,r enjoys the following optimality properties.6Proposition5.Let k∈N and f∈F.(i)For1≤p≤∞,f−ϕ∗k(f) Lp[0,1]≤k1/p·γk(f).(ii)For p=∞and everyϕ∈Φk,r,f−ϕ L∞[0,1]≥γk(f).(iii)For1≤p<∞,everyϕ∈Φk,r,and every m∈N with m>k,f−ϕ Lp[0,1]≥(m−k)1/p·γm(f). Proof.For p<∞,f−ϕ∗k(f) pL p[0,1]≤kj=1 f−ϕ∗k(f) p L p[τj−1,τj]=k·(γk(f))pfollows from(11)and(12).For p=∞,(i)is verified analogously.Consider a polynomial splineϕ∈Φk,r and let0=t0<...<t k=1denote the corresponding knots.Furthermore,letρ∈]0,1[.For the proof of(ii)we putσj=τj,ρ·γk (f)(f).for j=0,...,k.Thenσk<1,which implies[σj−1,σj]⊆[t j−1,t j] for some j∈{1,...,k}.Consequently,by Lemma4,f−ϕ L∞[0,1]≥ f−ϕ L∞[σj−1,σj]≥infπ∈Πrf−π L∞[σj−1,σj]=ρ·γk(f).For the proof of(iii)we defineσℓ=τℓ,ρ·γm(f)(f) forℓ=0,...,m.Thenσm<1,which implies[σℓi−1,σℓi]⊆[t ji−1,t ji]for some indices1≤j1≤...≤j m−k≤k and1≤ℓ1<...<ℓm−k≤m. Hence,by Lemma4,f−ϕ pL p[0,1]≥m−ki=1infπ∈Πr f−π p L p[σℓi−1,σℓi]=(m−k)·ρp·(γm(f))p.for1≤p<∞.Lettingρtend to one completes the proof.74Approximation of Integrated Wiener Processes Let W denote a Wiener process and consider the s-fold integrated Wiener pro-cesses W(s)defined by W(0)=W andW(s)(t)= t0W(s−1)(u)dufor t≥0and s∈N.We briefly discuss some properties of W(s),that will be important in the sequel.The scaling property of the Wiener process implies that for everyρ>0the process(ρ−(s+1/2)·W(s)(ρ·t))t≥0is an s-fold integrated Wiener process,too. This fact will be called the scaling property of W(s).While W(s)has no longer independent increments for s≥1,the influence of the past is very explicit.For z>0we define z W(s)inductively byzW(0)(t)=W(t+z)−W(z)andzW(s)(t)= t0z W(s−1)(u)du.Then it is easy to check thatW(s)(t+z)=s i=0t iLemma6.The s-fold integrated Wiener process W(s)satisfiesP(W(s)∈F)=1.For everyε>0the random variablesξj,εform an i.i.d.sequence withξ1,εd=ε1/β·ξ1,1and E(ξ1,1)<∞.Proof.We claim thatE(τj,ε(W(s)))<∞(14) for every j∈N.For the case j=1let Z=δ[0,1](W(s))and note thatδ[0,t](W(s))d=tβ·Zfollows for t>0from the scaling property of W(s).Hence we haveP(τ1,ε(W(s))<t)=P(δ[0,t](W(s))>ε)=P(Z>ε·t−β),(15) which,in particular,yieldsτ1,ε(W(s))d=ε1/β·τ1,1(W(s)).(16) According to Corollary17,there exists a constant c>0such thatP(Z≤η)≤exp(−c·η−1/(s+1/2))holds for everyη∈]0,1].We conclude thatP(τ1,1(W s))>t)≤exp(−c·t)if t≥1,which implies E(τ1,1(W(s)))<∞.Next,let j≥2,putτ=τj−1,ε(W(s))andτ′=τj,ε(W(s)),and assume that E(τ)<∞.From the representation(13)and the fact that r≥s we deriveδ[τ,t](W(s))=δ[0,t−τ](τW(s)),and hence it follows thatτ′=τ+τ1,ε(τW(s)).(17) We have E(τ1,ε(τW(s)))<∞,sinceτW(s)is an s-fold integrated Wiener process again,and consequently E(τ′)<∞.We turn to the properties of the sequenceξj,ε.Due to(16)and(17)we have ξj,ε=τ1,ε(τW(s))d=τ1,ε(W(s))d=ε1/β·ξ1,1. Furthermore,ξj,εand(1[0,τ](t)·W(s)(t))t≥0are independent because of the strong Markov property of W(s),and thereforeξj,εand(ξ1,ε,...,ξj−1,ε)are independent as well.9It remains to show that the trajectories of W(s)a.s.satisfy(9).By the properties of the sequenceξj,εwe haveτj,ε(W(s))d=ε1/β·τj,1(W(s)).(18) Observing(14)we conclude thatP(limε→0τj,ε(W(s))≥t)=limε→0P(τj,ε(W(s))≥t)=limε→0P(τj,1(W(s))≥t/ε1/β)=0for every t>0,which completes the proof.Because of Lemma6,Proposition5yields sharp upper and lower bounds for the error of spline approximation of W(s)in terms of the random variableV k=γk(W(s)).Remark7.Note that W(s)a.s.satisfies W(s)|[u,v]∈Πr for all0≤u<v. Assume that p<∞.Then v→δ[u,v](W(s))is a.s.strictly increasing for all u≥0.We use Lemma4.(iii)and Lemma6to conclude that,with probability one,V k is the unique solution ofτk,Vk(W(s))=1.Consequently,we a.s.have equality in Proposition5.(i)for1≤p<∞,too. Note that with positive probability solutionsεof the equationτk,ε(W(s))=1 fail to exist in the case p=∞.To complete the analysis of spline approximation methods we study the asymptotic behavior of the sequence V k.Lemma8.For every1≤q<∞,(E V qk)1/q≈(k·E(ξ1,1))−β.Furthermore,with probability one,V k≈(k·E(ξ1,1))−β.Proof.PutS k=1/k·k j=1ξj,1and use(18)to obtainP(V k≤ε)=P(τk,ε(W(s))≥1)=P(k−β·S−βk≤ε).(19) ThereforeE(V qk )=k−βq·E(S−βqk),10and for thefirst statement it remains to show thatE(S−βqk)≈(E(ξ1,1))−βq.The latter fact follows from Proposition15,if we can verify thatξ1,1has a proper lower tail behavior(28).To this end we use(15)and the large deviation estimate(32)to obtainP(ξ1,1≤η)=P(δ[0,1](W(s))≥η−β)≤P( W(s) Lp[0,1]≥η−β)≤exp(−c·η−2β)with some constant c>0for allη≤1.In order to prove the second statement,putS∗k=(k·σ2)−1/2·kj=1(ξj,1−µ),whereµ=E(ξ1,1)andσ2denotes the variance ofξ1,1.Letρ>1.Then P(V k>ρ·(k·µ)−β)=P(S k<ρ−1/β·µ)=P(S∗k<k1/2· ρ)withρ=(ρ−1/β−1)/σ·µ<0,due to(19).We apply a local version of the central limit theorem,which holds for i.i.d.sequences with afinite third moment,see[18,Thm.V.14],to obtain P(V k>ρ·(k·µ)−β)≤c1·k−1/2·(1+k1/2·| ρ|)−3+(2π)−1/2· k1/2·eρ−∞exp(−u2/2)du≤c2·k−2with constants c i>0.For everyρ<1we getP(V k<ρ·(k·µ)−β)≤c2·k−2(20) in the same way.It remains to apply the Borel-Cantelli Lemma.Observe Remark7and use Lemma8to obtain(4)and(5)for the methods X∗k=ϕ∗k(W(s)).Clearly,(4)implies the upper bounds in(1),(2),and(3).For the proof of the lower bound in(2)we apply Proposition5.(iii)withm=⌊β/(s+1/2)·k⌋.Then we have(m−k)1/p·(E V q m)1/q≈k−(s+1/2)·p−1/p·β−β·(s+1/2)s+1/2·(E(ξ1,1))−β,11as ing the second statement in Lemma 8,the lower bound in (6)is shown in the same way.It remains to prove the lower bounds for e av k,r (W (s ),L p ,q )in Theorem 2.Proof of the lower bound in (1).Let k ∈N and consider X k ∈N r such that ζ( Xk )≤k ,i.e.,∞ℓ=1ℓ·P (B ℓ)≤k (21)for B ℓ= X(·)∈Φℓ,r \Φℓ−1,r,where Φ0,r =∅.By Proposition 5.(ii),E W (s )− X k q L ∞[0,1]≥∞ ℓ=1E (1B ℓ·V q ℓ).For ̺∈]0,1[,µ=E (ξ1,1),and L ∈N we defineA ℓ=V ℓ>ρ·(ℓ·µ)−β ,andC L =Lℓ=1B ℓ.Since γℓ(f )≥γℓ+1(f )for f ∈F ,we obtainEW (s )− X k q L ∞[0,1]≥L ℓ=1E (1B ℓ·V qL )+∞ℓ=L +1E (1B ℓ·V q ℓ)≥L ℓ=1E (1B ℓ∩A L ·V qL )+∞ℓ=L +1E (1B ℓ∩A ℓ·V q ℓ)≥ρq µ−βq· L −βq ·P (C L ∩A L )+∞ l =L +1ℓ−βq ·P (B ℓ∩A ℓ) .From (20)we infer that P (A c ℓ)≤c 1·ℓ−2with a constant c 1>0.Hence there exists a constant c 2>0such thatΓ(L )=L−βq·P (C L )+∞ℓ=L +1ℓ−βq ·P (B ℓ)−c 2·L −βq −1satisfies ρ−q µβq ·EW (s )− X k q L ∞[0,1]≥Γ(L )(22)for every L ∈N .12Putα=(1+2βq)/(2+2βq),and take L(k)∈[kα−1,kα].We claim that there exists a constant c3>0such thatkβq·Γ(L(k))≥ 1−k−(1−α)βq 1+βq−c3·k−1/2.(23) First,assume that P(C L)≥k−(1−α)βq.Thenkβq·Γ(L(k))≥kβq· k−αβq·P(C L)−c2·(kα−1)−βq−1≥1−c3·k−1/2with a constant c3>0.Next,assume P(C L)<k−(1−α)βq and use(21)to derive1−k−(1−α)βq<∞ℓ=L+1P(Bℓ)=∞ℓ=L+1(ℓ·P(Bℓ))βq/(1+βq)·(ℓ−βq·P(Bℓ))1/(1+βq)≤ ∞ ℓ=L+1ℓ·P(Bℓ) βq/(1+βq)· ∞ ℓ=L+1ℓ−βq·P(Bℓ) 1/(1+βq)≤kβq/(1+βq)· ∞ ℓ=L+1ℓ−βq·P(Bℓ) 1/(1+βq). Consequently,kβq·Γ(L(k))≥kβq· ∞ ℓ=L+1ℓ−βq·P(Bℓ)−c2·(kα−1)−βq−1≥ 1−k−(1−α)βq 1+βq−c3·k−1/2,which completes the proof of(23).By(22)and(23),E W(s)− X k q L∞[0,1] ρqµ−βq·k−βqfor everyρ∈]0,1[.Finally,for the proof of the lower bound in(3)it suffuces to establish the lower bound claimed for e av k,r(W(s),L1,1).For further use,we shall prove a more general result.Lemma9.For every s∈N there exists a constant c>0with the following property.For every X∈N r,every A∈A with P(A)≥4/5,and every t∈]0,1] we haveE 1A· W(s)− X L1[0,t] ≥c·t s+3/2·k−(s+1/2).13Proof.Because of the scaling property of W(s)it suffices to study the particular case t=1.PutB={ X∈Φ2k,r},and observe that P(B)≥1/2follows fromξ( X)≤k.Due to Lemma6and Proposition5.(iii),1B· W(s)− X L1[0,1]≥1B·2k·V4k.Putµ=E(ξ1,1),choose0<c<(2µ)−β,and defineD k={V k≥c·k−β}.By(19)we obtainP(D k)=P(S k<c−1/β)≥P(S k<2µ).HenceP(D k)=1limk→∞due to the law of large numbers,and consequently P(B∩D k)≥2/5if k is sufficiently large,say k≥k0.We conclude that1A∩B∩D4k· W(s)− X L1[0,1]≥1A∩B∩D4k·c·21−2β·k−(s+1/2)and P(A∩B∩D4k)≥1/5if4k≥k0.Take expectations to complete the proof.Lemma9with A=Ωand t=1yields the lower bound in(3)5Approximation of Diffusion ProcessesLet X denote the solution of the stochastic differential equation(7)with initial value x0,and recall that the drift coefficient a and the diffusion coefficient b are supposed to satisfy conditions(A1)–(A3).In the following we use c to denote unspecified positive constants,which may only depend on x0,a,b and the averaging parameter1≤q<∞.Note that<∞(24)E X qL∞[0,1]andE sup t∈[s1,s2]|X(t)−X(s1)|q ≤c·(s2−s1)q/2(25) for all1≤q<∞and0≤s1≤s2≤1,see[9,p.138].145.1Upper BoundsIn order to establish upper bounds,it suffices to consider the case of p=∞and r=0,i.e.,nonlinear approximation in supremum norm with piecewise constant splines.We dissect X into its martingale partM(t)= t0b(X(s))dW(s)andY(t)=x0+ t0a(X(s))ds.Lemma10.For all1≤q<∞and k∈N,there exists an approximation Y∈N k,0such thatE Y− Y q L∞[0,1] 1/q≤c·k−1.Proof.Put g Lip=sup0≤s<t≤1|g(t)−g(s)|/|t−s|for g:[0,1]→R,and defineY=k j=11](j−1)/k,j/k]·Y((j−1)/k).By(A1)and(24),E Y− Y q L∞[0,1]≤E Y q Lip·k−q≤c· 1+E X q L∞[0,1] ·k−q≤c·k−q.Lemma11.For all1≤q<∞and k∈N,there exists an approximation M∈N k,0such thatE M− M q L∞[0,1] 1/q≤c·k−1/2.Proof.LetX=k j=11](j−1)/k,j/k]·X((j−1)/k).Clearly,by(25),E X− X q L2[0,1] 1/q≤c·k−1/2.DefineR(t)= t0b( X(s))dW s.15By the Burkholder-Davis-Gundy inequality and(A2),E M−R q L∞[0,1] 1/q≤c· E 10(b(X(s))−b( X(s)))2ds q/2 1/q≤c· E X− X q L2[0,1] 1/q≤c·k−1/2.(26) Note thatR= R+V,whereR=k j=11](j−1)/k,j/k]·R((j−1)/k)andV=kj=11](j−1)/k,j/k]·b(X((j−1)/k))·(W−W((j−1)/k)).According to Theorem2,there exists an approximation W∈N k,0such thatE W− W 2q L∞[0,1] 1/(2q)≤c·k−1/2. Using W we define V∈N2k,0byV=k j=11](j−1)/k,j/k]·b(X((j−1)/k))·( W−W((j−1)/k)).Clearly,V− V L∞[0,1]≤ b(X) L∞[0,1]· W− W L∞[0,1].Observing(24)and(A2),we conclude thatE V− V q L∞[0,1] 1/q≤ E b(X) 2q L∞[0,1] 1/(2q)· E W− W 2q L∞[0,1] 1/(2q)≤c·k−1/2.(27) Wefinally define M∈N2k,0by M= R+ V.SinceM− M=(M−R)+(V− V),it remains to apply the estimates(26)and(27)to complete the proof.The preceding two lemma imply e k,0(X,L∞,q)≤c·k−1/2.165.2Lower BoundsFor establishing lower bounds it suffices to study the case p=q=1.Moreover, we assume without loss of generality that b(x0)>0.Chooseη>0as well as a function b0:R→R such that(a)b0is differentiable with a bounded and Lipschitz continuous derivative,(b)inf x∈R b0(x)≥b(x0)/2,(c)b0=b on the interval[x0−η,x0+η].We will use a Lamperti transform based on the space-transformationg(x)= x x01dW(s).b0(X(s))The idea of the proof is as follows.We show that any good spline approxima-tion of X leads to a good spline approximation of H(X).However,since with a high probability,X stays within[x0−η,x0+η]for some short(but nonrandom) period of time,approximation of H(X)is not easier than approximation of W, modulo constants.First,we consider approximation of H1(X).Lemma12.For every k∈N there exists an approximation X1∈N k,0such thatE H1(X)− X1 L1[0,1]≤c·k−1. Proof.Observe that g′a+g′′/2·b2 (x)≤c·(1+x2),and proceed as in the Proof of Lemma10.Next,we relate approximation of X to approximation of H2(X).Lemma13.For every approximation X∈N r there exists an approximation X2∈N r such thatζ( X2)≤2·ζ( X)andE H2(X)− X2 L1[0,1]≤c· E X− X L1[0,1]+1/ζ( X) .17Proof.For afixedω∈Ωlet X(ω)be given byX(ω)=k j=11]t j−1,t j]·πj.We refine the corresponding partition to a partition0= t0<...< t e k=1 that contains all the points i/ℓ,whereℓ=ζ( X).Furthermore,we define the polynomials πj∈Πr byX(ω)=e k j=11]e t j−1,e t j]· πj.Put f=X(ω)and defineX2(ω)=e k j=11]e t j−1,e t j]·q jwith polynomialsq j=g(f( t j−1))+g′(f( t j−1))·( πj−f( t j−1))∈Πr.Let f2= X2(ω).If t∈ t j−1, t j ⊆](i−1)/ℓ,i/ℓ],then|H2(f)(t)− f2(t)|= g(f(t))−g(f( t j−1))−g′(f( t j−1))·( πj(t)−f( t j−1))≤ g(f(t))−g(f( t j−1))−g′(f( t j−1))·(f(t)−f( t j−1))+ g′(f( t j−1)) ·|f(t)− πj(t)|≤c· |f(t)−f( t j−1)|2+|f(t)− πj(t)|≤c· sup|f(t)−f((i−1)/ℓ)|2+|f(t)− πj(t)| .t∈](i−1)/ℓ,i/ℓ]Consequently,we may invoke(25)to deriveE H2(X)− X2 L1[0,1]≤c· 1/ζ( X)+E X− X L1[0,1] . Moreover,ζ( X2)≤2·ζ( X).Finally,we establish a lower bound for approximation of H(X). Lemma14.For every approximation X∈N r,E H(X)− X L1[0,1]≥c·(ζ( X))−1/2.18Proof.Choose t0∈]0,1]such thatA= sup t∈[0,t0]|X(t)−x0|≤ηsatisfies P(A)≥4/5.Observe that1A· H(X)− X L1[0,1]≥1A· W− X L1[0,t0],and apply Lemma9for s=0.Proof of the lower bound in Theorem3.Consider any approximation X∈N r with k−1<ζ( X)≤k,and choose X1and X2according to Lemma12and Lemma13,respectively.ThenE H(X)−( X2− X1) L1[0,1]≤E H2(X)− X2 L1[0,1]+E H1(X)− X1 L1[0,1]≤c· E X− X L1[0,1]+(ζ( X))−1+k−1≤c· E X− X L1[0,1]+k−1 .On the other hand,ζ( X2− X1)≤ζ( X2)+k≤3·k,so thatE H(X)−( X2− X1) L1[0,1]≥c·k−1/2follows from Lemma14.We conclude thatE X− X L1[0,1]≥c·k−1/2,as claimed.A Convergence of Negative Moments of MeansLet(ξi)i∈N be an i.i.d.sequence of random variables such thatξ1>0a.s.and E(ξ1)<∞.PutS k=1/k·k i=1ξi.Proposition15.For everyα>0,lim inf k→∞E(S−αk)≥(E(ξ1))−α.IfP(ξ1<v)≤c·vρ,v∈]0,v0],(28) for some constants c,ρ,v0>0,thenlim k→∞E(S−αk)=(E(ξ1))−α.19Proof.Put µ=E (ξ1)and defineg k (v )=α·v −(α+1)·P (S k <v ).Thanks to the weak law of large numbers,P (S k <v )tends to 1]µ,∞[(v )for every every v =µ.Hence,by Lebesgue’s theorem,lim k →∞∞µ/2g k (v )dv =µ−α.(29)SinceE (S −αk )=∞P (S −αk>u )du =∞g k (v )dvthe asymptotic lower bound for E (S −αk )follows from (29).Given (28),we may assume without loss of generality that c ·v ρ0<1.We first consider the case ξ1≤1a.s.,and we putA k = µ/2x 0/kg k (v )dv and B k = x 0/kg k (v )dv.For v 0/k ≤v ≤µ/2we use Hoeffding’s inequality to obtaing k (v )≤α·v −(α+1)·P (|S k −µ|>µ/2)≤α·(k/v 0)α+1·2exp(−k/2·µ2),which implieslim k →∞A k =0.On the other hand,if ρk >α,thenB k =kα+1·α·v 0v−(α+1)·Pk i =1ξi <vdv≤k α+1·α·v 0v −(α+1)·(P (ξ1<v ))k dv≤k α+1·α·c k ·v 0v ρk −(α+1)dv =kα+1·α·(ρk −α)−1·c k ·v ρk −α0,and thereforelim k →∞B k =0.In view of (29)we have thus proved the proposition in the case of boundedvariables ξi .In the general case put ξi,N =min {N,ξi }as well as S k,N =1/k · k i =1ξi,N ,and apply the result for bounded variables to obtainlim sup k →∞E (S −αk )≤inf N ∈N lim sup k →∞E (S −αk,N )=inf N ∈N(E ξ1,N )−α=(E ξ1)−αby the monotone convergence theorem.20B Small Deviations of W(s)fromΠrLet X denote a centered Gaussian random variable with values in a normed space(E, · ),and consider afinite-dimensional linear subspaceΠ⊂E.We are interested in the small deviation behavior ofd(X,Π)=infπ∈ΠX−π .Obviously,P( X ≤ε)≤P(d(X,Π)≤ε)(30) for everyε>0.We establish an upper bound for P(d(X,Π)≤ε)that involves large deviations of X,too.Proposition16.If dim(Π)=r thenP(d(X,Π)≤ε)≤(4λ/ε)r·P( X ≤2ε)+P( X ≥λ−ε)for allλ≥ε>0.Proof.Put Bδ(x)={y∈E: y−x ≤δ}for x∈E andδ>0,and consider the sets A=Π∩Bλ(0)and B=Bε(0).Then{d(X,Π)≤ε}⊂{X∈A+B}∩{ X ≥λ−ε},and therefore it suffices to proveP(X∈A+B)≤(4λ/ε)r·P( X ≤2ε).(31) Since1/λ·A⊂Π∩B1(0),theε-covering number of A is not larger than (4λ/ε)r,see[1,Eqn.(1.1.10)].HenceA⊂n i=1Bε(x i)for some x1,...,x n∈E with n≤(4λ/ε)r,and consequently,A+B⊂ni=1B2ε(x i).Due to Anderson’s inequality we haveP(X∈B2ε(x i))≤P(X∈B2ε(0)),which implies(31).Now,we turn to the specific case of X=(W(s)(t))t∈[0,1]and E=L p[0,1], and we consider the subspaceΠ=Πr of polynomials of degree at most r.21。