酮洛芬醇质体凝胶的研制

酮洛芬醇质体凝胶的研制
王军;何文;罗丽萍
【期刊名称】《广东药学院学报》
【年(卷),期】2012(28)3
【摘要】Objective To prepare ketoprofen ethosomal gels and study the quality preliminarily. Methods The ketoprofen ethosomes were prepared by injection method. The optimal formulation and preparation were screened by orthogonal experiments. The ethosomal gels were prepared by mixing method. The content of ketoprofen was determined by HPLC and the entrapment efficiency of the ethosomes was measured by dialysis method. Results The shape of the ketoprofen ethosomes was spherical with homogeneous size and the average value of mean particle size
was(185.8 ±58.2)nm. The average encapsulation efficiency was (72.6
±3.2)%. The linear range of ketoprofen was 1.5-12.0 μg · mL-1(r=0.999 9). The average recovery of ketoprofen is (99.3 ±1. 5)%. Conclusion The preparation is simple and reasonable with promising repeatability and controllable quality.%目的研制酮洛芬醇质体凝胶,并对其质量进行初步考察.方法采用注入法制备酮洛芬醇质体,通过正交实验优选较佳处方和工艺；采用研和法制备醇质体凝胶,HPLC测定其中主药的含量,透析法测定包封率.结果酮洛芬醇质体形态圆整,粒径均匀,平均粒径为(185.8±58.2)nm,平均包封率为(72.6±3.2)％.酮洛芬线性浓度范围为1.5-12.0μg·mL-1(r=0.9999),平均回收率为(99.3±1.5)％.结论本制剂制备工艺简单可行,重现性好,质量稳定可控.
【总页数】3页(P236-238)
【作者】王军;何文;罗丽萍
【作者单位】武汉大学人民医院药学部,湖北武汉430060;武汉大学人民医院药学部,湖北武汉430060;武汉大学人民医院药学部,湖北武汉430060
【正文语种】中文
【中图分类】R944
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