PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS
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专利名称：PYRIDOPYRIMIDINONE ANTIANGINAL AGENTS
发明人：BELL, Andrew Simon,TERRETT, Nicholas Kenneth
申请号：EP93917761.0
申请日：19930804
公开号：EP0656898A1
公开日：
19950614
专利内容由知识产权出版社提供
摘要：Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is H, C¿1?-C4 alkyl, CN or CONR?4R5; R2 is C¿2-C4 alkyl; R3 is SO¿2?NR?6R7, NO¿2, NH2, NHCOR8, NHSO¿2R?8 or N(SO¿2R?8)2; R?4 and R5¿ are each independently selected from H and C¿1?-C4 alkyl; R?6 and R7¿ are each independently selected from H and C¿1?-C4 alkyl optionally substituted with CO2R?9¿, OH, pyridyl, 5-isoxazolin-3-onyl, morpholino or 1-imidazolidin-2-onyl; or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino, 1-pyrazolyl or 4-(NR10)-1 piperazinyl group wherein any of said groups may optionally be substituted with one or two substituents selected from C¿1?-C4 alkyl, CO2R?9, NH¿2 and OH; R8 is C1-C4 alkyl or pyridyl; R9 is H or C¿1?-C4 alkyl; and R?10¿ is H, C¿1?-C4 alkyl or (hydroxy)C2-C3 alkyl; are selective cGMP PDE inhibitors useful in the treatment of, inter alia, cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.
申请人：Pfizer Research and Development Company, N.V./S.A.
地址：Alexandra House, Earlsfort Centre, Earlsfort Terrace Dublin 2 IE
国籍：IE
代理机构：Moore, James William, Dr., et al 更多信息请下载全文后查看。