BeppoSAX observations of the X-ray binary pulsar 4U1626-67
BeppoSAX Observations of 2 Jy Lobe-dominated Broad-Line Sources the Discovery of a Hard X-r
a r X i v :a s t r o -p h /9801048v 1 7 J a n 19981BeppoSAX Observations of 2Jy Lobe-dominated Broad-Line Sources:the Discovery of a Hard X-ray ComponentRaffaella Morganti a ,Paolo Padovani b ,Joachim Siebert c ,Andrea Cimatti d ,Clive N.Tadhunter e and Fausto Vagnetti fa Istituto di Radioastronomia,Via Gobetti 101,I-40129Bologna,ItalybDipartimento di Fisica,II Universit`a di Roma “Tor Vergata”,Via della Ricerca Scientifica 1,I-00133Roma,ItalySpace Telescope Science Institute,3700San Martin Drive,Baltimore,MD.21218,USA Affiliated to the Astrophysics Division,Space Science Department,European Space AgencycMax-Planck Institut f¨u r Extraterrestrische Physik,Giessenbachstrasse,D-85740Garching bei M¨u nchen,Germanyd Osservatorio Astrofisico di Arcetri,Largo E.Fermi 5,I-50125Firenze,Italye Dept.of Physics,University of Sheffield,Sheffield S37RH,UKfDipartimento di Fisica,II Universit`a di Roma “Tor Vergata”,Via della Ricerca Scientifica 1,I-00133Roma,ItalyWe present new BeppoSAX LECS,MECS,and PDS observations of five lobe-dominated,broad-line active galactic nuclei selected from the 2Jy sample of southern radio sources.These include three radio quasars and two broad-line radio galaxies.ROSAT PSPC data,available for all the objects,are also used to better constrain the spectral shape in the soft X-ray band.The collected data cover the 0.1−10keV energy range,reaching 40keV for one source.Detailed spectral fitting shows that all sources have a flat hard X-ray spectrum with energy index αx ∼0.75in the 2−10keV energy range.This is a new result,which is at variance with the situation at lower energies where these sources exhibit steeper spectra.Spectral breaks ∼0.5at 1−2keV characterize the overall X-ray spectra of our objects.The flat,high-energy slope is very similar to that displayed by flat-spectrum/core-dominated quasars,which suggests that the same emission mechanism (most likely inverse Compton)produces the hard X-ray spectra in both classes.Contrary to the optical evidence for some of our sources,no absorption above the Galactic value is found in our sample.Finally,a (weak)thermal component is also present at low energies in the two broad-line radio galaxies included in our study.1.The Astrophysical ProblemThere is abundant evidence that strong anisotropies play a major role in the observed characteristics of radio loud active galactic nuclei (AGN)and this has led to suggest a unification of all high-power radio sources (Barthel 1989;see Antonucci 1993and Urry &Padovani 1995for a review).According to this scheme:1)the lobe-dominated,steep-spectrum radio quasars (SSRQ)and the core-dominated,flat-spectrum radio quasars (FSRQ)are believed to be increasingly aligned versions of Fanaroff-Riley type II (FR II;Fanaroff&Riley 1974)radio galaxies.2)the broad-line (FWHM ≈2000km s −1)ra-dio galaxies (BLRG)have a still uncertain place.They could represent either objects intermediate between quasars and radio galaxies,(i.e.with the nucleus only partly obscured and the broad emis-sion lines just becoming visible at the edge of the obscuring torus)or low-redshift,low-power equiv-alent of quasars.2Table1Sample PropertiesOF–1090.5740.57QSO...16,86422-Sep-96 Pictor A0.0350.03BLRG5,27114,79812/13-Oct-96 OM–1610.5540.16QSO13,27128,24811/12-Jan-97 PHL16570.2000.06QSO4,70417,42929-Oct-96 PKS2152–690.0270.03BLRG...9,36729-Sep-961Throughout this paper the values H0=50km s−1 Mpc−1and q0=0have been adopted and spectral in-dices are written Sν∝ν−α.SDC on-line archive and on the XIMAGE pack-age.Spectra were accumulated for each obser-vations using the SAXSELECT tool and the re-commended extraction radii.Spectral analysis was performed with the XSPEC9.00package,using the response matri-ces released by SDC in early1997.The spectra were rebinned such that each new bin contains at least20counts.Spectralfits for the three objects for which LECS data were available show that the fitted N H values are consistent with the Galactic ones.We then assumed Galactic N H in the com-bined LECS and MECSfits.For the two objects without LECS data this assumption is also justi-fied by the fact that thefit to the MECS data is not strongly dependent on N H.From the combined LECS and MECSfits all sources have veryflat X-ray energy indices,with a mean value αx =0.75±0.02.One object (PHL1657)shows evidence of a spectral break ∼0.5at E∼1keV.All our objects have ROSAT PSPC data(4tar-gets and one from the RASS).We then put the BeppoSAX and ROSAT PSPC data together to better constrain the shape of the X-ray spectra, especially at low energies.Two of our sources,in fact,have no LECS data,while for the remaining three only less than10LECS bins are available below1keV.Atfirst,wefitted the BeppoSAX and ROSAT data separately with a single power-law model modified at low energies by absorption due to neutral gas in the Galaxy.From this preliminary analysis it was clear that two different slopes for the power law are necessary at low and high en-ergies.3 Table2ROSAT PSPC,BeppoSAX LECS and MECS spectralfitsOF–1091.33+0.11−0.100.80+0.20−0.211.32+1.39−0.371.06(71)3.7±0.1Pictor A0.79+0.07−0.070.56+0.21−0.383.92+4.88−3.100.91(157)13.8±0.3OM–161...0.77+0.11−0.11...0.79(86)2.5±0.1PHL16571.42+0.09−0.090.75+0.12−0.121.45+0.50−0.290.96(124)8.6±0.2PKS2152–691.23+0.57−0.410.70+0.18−0.181.69+2.01−0.750.98(71)7.5±0.24Figure3.αX vs core dominance R for SSRQ and BLRG from our sample(filled circles),SSRQ and FSRQ from literature(open triangles and squares respectively)hard X-ray spectrum withαX∼0.75at E>1−2 keV similar to what found in core-dominated ra-dio quasars.Fig.3shows the2−10keV energy indices for core dominated FSRQ and for the ob-jects in our sample.The FSRQ sample is het-erogeneous while our sample,although relatively small,is well defined and has very well deter-mined spectral indices.Nevertheless,the FSRQ are characterized by α2−10keV =0.70±0.06, consistent with our results.Thus,it seems natural to attribute the hard X-ray component to the same emission mecha-nism suggested for FSRQ,i.e.synchrotron self-Compton emission.2)various previous studies had found that SSRQ displayed a steep soft X-ray spectrum.In fact,despite the hard component at higher en-ergies,we nevertheless observe a steeper spec-trum at lower energies.Our bestfits to the whole 0.1−10keV range indeed require a spectral break ∼0.5between the soft and hard energy slopes at about1−2keV.The dispersion in the en-ergy indices is larger for the soft component.We findσ(αS)=0.28whileσ(αH)=0.10,which might suggest a more homogeneous mechanism at higher energies.This steep component could be related to the UV bump observed in most radio-quiet quasars or be due to synchrotron emission or a combina-tion of both.Work is in progress to tackle this problem.3)Finally,a thermal component is also present at low energies in the two BLRG but contributes only≈10%of theflux.REFERENCES1.Antonucci,R.1993,ARAA,31,4732.Barthel,P.D.1989,ApJ,336,3193.Fanaroff,B.L.,&Riley,J.M.1974,MNRAS,167,31P4.Morganti,R.,Killeen,N.E.B.,&Tadhunter,C.N.1993,MNRAS,263,10235.Morganti,R.,Oosterloo,T.A.,Reynolds,J.E.,Tadhunter,C.N.,&Migenes,V.1997MNRAS,284,5416.Sambruna,R.,Barr,P.,Giommi,P.,Maraschi,L.,Tagliaferri,G.,&Treves,A.1994,ApJS,95,3717.Shastri,P.,Wilkes,B.J.,Elvis,M.,&Mc-Dowell,J.1993,ApJ,410,298.Siebert,J.,Brinkmann,W.,Morganti,R.,Tadhunter,C.N.,Danziger,I.J.,Fosbury, R.A.E.,&di Serego Alighieri,S.1996,MN-RAS,279,13319.Tadhunter,C.N.,Morganti,R.,di SeregoAlighieri,S.,Fosbury,R.A.E.,&Danziger,I.J.1993,MNRAS,263,99910.Tadhunter,C.N.,Morganti,R.,Robinson A.,Dickson R.,Villar-Martin M.&Fosbury,R.A.E.1997,MNRAS,in press11.Urry,C.M.,&Padovani,P.1995,PASP,107,80312.Wall,J.V.,&Peacock,J.A.1985,MNRAS,216,17313.Wilkes,B.J.,&Elvis,M.1987,ApJ,323,243。
贝西沙星英文说明书
HIGHLIGHTS OF PRESCRIBING INFORMATIONThese highlights do not include all the information needed to use Besivance safely and effectively. See full prescribing information for Besivance.Besivance TM (besifloxacin ophthalmic suspension) 0.6%Sterile topical ophthalmic dropsInitial U.S. Approval: 2009INDICATIONS AND USAGEBesivance™ (besifloxacin ophthalmic suspension) 0.6%, is a quinolone antimicrobial indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following bacteria:CDC coryneform group GCorynebacterium pseudodiphtheriticum*, Corynebacterium striatum*, Haemophilus influenzae, Moraxella lacunata*, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus hominis*, Staphylococcus lugdunensis*, Streptococcus mitis group, Streptococcus oralis, Streptococcus pneumoniae, Streptococcus salivarius**Efficacy for this organism was studied in fewer than 10 infections. (1)DOSAGE AND ADMINISTRATIONInstill one drop in the affected eye(s) 3 times a day, four to twelve hours apart for 7 days. (2)DOSAGE FORMS AND STRENGTHS7.5 mL size bottle filled with 5 mL of besifloxacin ophthalmic suspension, 0.6% (3)CONTRAINDICATIONSNoneWARNINGS AND PRECAUTIONSTopical Ophthalmic Use Only. (5.1)Growth of Resistant Organisms with Prolonged Use. (5.2)Avoidance of Contact Lenses. Patients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis or during the course of therapy with Besivance™ (5.3)ADVERSE REACTIONSThe most common adverse event reported in 2% of patients treated with Besivance™ was conjunctival redness. (6)To report SUSPECTED ADVERSE REACTIONS, contact Bausch & Lomb Incorporated at 1-800-323-0000 or FDA at 1-800-FDA-1088 or /medwatchTo report SUSPECTED ADVERSE REACTIONS, contact at or FDA at 1-800-FDA-1088 or /medwatchSee 17 for PATIENT COUNSELING INFORMATIONRevised: 04/2009FULL PRESCRIBING INFORMATION: CONTENTS *1 INDICATIONS AND USAGE2 DOSAGE AND ADMINISTRATION3 DOSAGE FORMS AND STRENGTHS4 CONTRAINDICATIONS5 WARNINGS AND PRECAUTIONS5.1 Topical Ophthalmic Use Only5.2 Growth of Resistant Organisms with Prolonged Use5.3 Avoidance of Contact Lenses6 ADVERSE REACTIONS8 USE IN SPECIFIC POPULATIONS8.1 Pregnancy8.3 Nursing Mothers8.4 Pediatric Use8.5 Geriatric Use11 DESCRIPTION12 CLINICAL PHARMACOLOGY12.1 Mechanism of Action12.3 Pharmacokinetics12.4 Microbiology13 NONCLINICAL TOXICOLOGY13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility14 CLINICAL STUDIES16 HOW SUPPLIED/STORAGE AND HANDLING17 PATIENT COUNSELING INFORMATIONPACKAGE/LABEL PRINCIPAL DISPLAY PANEL* Sections or subsections omitted from the full prescribing information are not listedFULL PRESCRIBING INFORMATION1 INDICATIONS AND USAGEBesivance™ (besifloxacin ophthalmic suspension) 0.6%, is indicated for the treatment of bacterial conjunctivitis caused by susceptible isolates of the following bacteria:CDC coryneform group GCorynebacterium pseudodiphtheriticum*Corynebacterium striatum*Haemophilus influenzaeMoraxella lacunata*Staphylococcus aureusStaphylococcus epidermidisStaphylococcus hominis*Staphylococcus lugdunensis*Streptococcus mitis groupStreptococcus oralisStreptococcus pneumoniaeStreptococcus salivarius**Efficacy for this organism was studied in fewer than 10 infections.2 DOSAGE AND ADMINISTRATIONInvert closed bottle and shake once before use.Instill one drop in the affected eye(s) 3 times a day, four to twelve hours apart for 7 days.3 DOSAGE FORMS AND STRENGTHS7.5 mL bottle filled with 5 mL of besifloxacin ophthalmic suspension, 0.6%.4 CONTRAINDICATIONSNone5 WARNINGS AND PRECAUTIONS5.1 Topical Ophthalmic Use OnlyNOT FOR INJECTION INTO THE EYE.Besivance™ is for topical ophthalmic use only, and should not be injected subconjunctivally, nor should it be introduced directly into the anterior chamber of the eye.5.2 Growth of Resistant Organisms with Prolonged UseAs with other anti-infectives, prolonged use of Besivance™ (besifloxacin ophthalmic suspension) 0.6% may result in overgrowthof non-susceptible organisms, including fungi. If super-infection occurs, discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit-lamp biomicroscopy, and, where appropriate, fluorescein staining.5.3 Avoidance of Contact LensesPatients should not wear contact lenses if they have signs or symptoms of bacterial conjunctivitis or during the course of therapy with Besivance™.6 ADVERSE REACTIONSBecause clinical trials are conducted under widely varying conditions, adverse reaction rates observed in one clinical trial of a drug cannot be directly compared with the rates in the clinical trials of the same or another drug and may not reflect the rates observed in practice.The data described below reflect exposure to Besivance™ in approximately 1,000 patients between 1 and 98 years old with clinical signs and symptoms of bacterial conjunctivitis.The most frequently reported ocular adverse event was conjunctival redness, reported in approximately 2% of patients.Other adverse events reported in patients receiving Besivance™ occurring in approximately 1-2% of patients included: blurred vision, eye pain, eye irritation, eye pruritus and headache.8 USE IN SPECIFIC POPULATIONS8.1 PregnancyPregnancy Category C. Oral doses of besifloxacin up to 1000 mg/kg/day were not associated with visceral or skeletal malformations in rat pups in a study of embryo-fetal development, although this dose was associated with maternal toxicity (reduced body weight gain and food consumption) and maternal mortality. Increased post-implantation loss, decreased fetal body weights, and decreased fetal ossification were also observed. At this dose, the mean C max in the rat dams was approximately 20 mcg/mL, >45,000 timesthe mean plasma concentrations measured in humans. The No Observed Adverse Effect Level (NOAEL) for this embryo-fetal development study was 100 mg/kg/day (C max, 5 mcg/mL, >11,000 times the mean plasma concentrations measured in humans).In a prenatal and postnatal development study in rats, the NOAELs for both fetal and maternal toxicity were also 100 mg/kg/day.At 1000 mg/kg/day, the pups weighed significantly less than controls and had a reduced neonatal survival rate. Attainment of developmental landmarks and sexual maturation were delayed, although surviving pups from this dose group that were reared to maturity did not demonstrate deficits in behavior, including activity, learning and memory, and their reproductive capacity appeared normal.Since there are no adequate and well-controlled studies in pregnant women, Besivance™ should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.8.3 Nursing MothersBesifloxacin has not been measured in human milk, although it can be presumed to be excreted in human milk. Caution should be exercised when Besivance™ is administered to a nursing mother.8.4 Pediatric UseThe safety and effectiveness of Besivance™ in infants below one year of age have not been established. The efficacy of Besivance™in treating bacterial conjunctivitis in pediatric patients one year or older has been demonstrated in controlled clinical trials [see 14 CLINICAL STUDIES].There is no evidence that the ophthalmic administration of quinolones has any effect on weight bearing joints, even though systemic administration of some quinolones has been shown to cause arthropathy in immature animals.8.5 Geriatric UseNo overall differences in safety and effectiveness have been observed between elderly and younger patients.11 DESCRIPTIONBesivance™ (besifloxacin ophthalmic suspension) 0.6%, is a sterile ophthalmic suspension of besifloxacin formulated with DuraSite®* (polycarbophil, edetate disodium dihydrate and sodium chloride). Each mL of Besivance™ contains 6.63 mg besifloxacin hydrochloride equivalent to 6 mg besifloxacin base. It is an 8-chloro fluoroquinolone anti-infective for topical ophthalmic use.C19H21ClFN3O3•HClMol Wt 430.30Chemical Name: (+)-7-[(3R)-3-aminohexahydro-1H-azepin-1-yl]-8-chloro-1- cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride.Besifloxacin hydrochloride is a white to pale yellowish-white powder.Each mL Contains:Active: besifloxacin 0.6% (6 mg/mL);Preservative: benzalkonium chloride 0.01%Inactives: polycarbophil, mannitol, poloxamer 407, sodium chloride, edetate disodium dihydrate, sodium hydroxide and water for injection.Besivance™ is an isotonic suspension with an osmolality of approximately 290 mOsm/kg.12 CLINICAL PHARMACOLOGY12.1 Mechanism of ActionBesifloxacin is a fluoroquinolone antibacterial [see 12.4 Clinical Pharmacology, Microbiology].12.3 PharmacokineticsPlasma concentrations of besifloxacin were measured in adult patients with suspected bacterial conjunctivitis who received Besivance™ bilaterally three times a day (16 doses total). Following the first and last dose, the maximum plasma besifloxacinconcentration in each patient was less than 1.3 ng/mL. The mean besifloxacin C max was 0.37 ng/mL on day 1 and 0.43 ng/mL on day 6. The average elimination half-life of besifloxacin in plasma following multiple dosing was estimated to be 7 hours.12.4 MicrobiologyBesifloxacin is an 8-chloro fluoroquinolone with a N-1 cyclopropyl group. The compound has activity against Gram-positive and Gram-negative bacteria due to the inhibition of both bacterial DNA gyrase and topoisomerase IV. DNA gyrase is an essential enzyme required for replication, transcription and repair of bacterial DNA. Topoisomerase IV is an essential enzyme required for partitioning of the chromosomal DNA during bacterial cell division. Besifloxacin is bactericidal with minimum bactericidal concentrations (MBCs) generally within one dilution of the minimum inhibitory concentrations (MICs).The mechanism of action of fluoroquinolones, including besifloxacin, is different from that of aminoglycoside, macrolide, and β-lactam antibiotics. Therefore, besifloxacin may be active against pathogens that are resistant to these antibiotics and these antibiotics may be active against pathogens that are resistant to besifloxacin. In vitro studies demonstrated crossresistance between besifloxacin and some fluoroquinolones.In vitro resistance to besifloxacin develops via multiple-step mutations and occurs at a general frequency of < 3.3 x 10-10 for Staphylococcus aureus and < 7 x 10-10 for Streptococcus pneumoniae.Besifloxacin has been shown to be active against most isolates of the following bacteria both in vitro and in conjunctival infections treated in clinical trials as described in the INDICATIONS AND USAGE section:CDC coryneform group GCorynebacterium pseudodiphtheriticum*Corynebacterium striatum*Haemophilus influenzaeMoraxella lacunata*Staphylococcus aureusStaphylococcus epidermidisStaphylococcus hominis*Staphylococcus lugdunensis*Streptococcus mitis groupStreptococcus oralisStreptococcus pneumoniaeStreptococcus salivarius**Efficacy for this organism was studied in fewer than 10 infections.13 NONCLINICAL TOXICOLOGY13.1 Carcinogenesis, Mutagenesis, Impairment of FertilityLong-term studies in animals to determine the carcinogenic potential of besifloxacin have not been performed.No in vitro mutagenic activity of besifloxacin was observed in an Ames test (up to 3.33 mcg/plate) on bacterial tester strains Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA. However, it was mutagenic in S. typhimurium strain TA102 and E. coli strain WP2(pKM101). Positive responses in these strains have been observed with other quinolones and are likely related to topoisomerase inhibition.Besifloxacin induced chromosomal aberrations in CHO cells in vitro and it was positive in an in vivo mouse micronucleus assayat oral doses ≥ 1500 mg/kg. Besifloxacin did not induce unscheduled DNA synthesis in hepatocytes cultured from rats given thetest compound up to 2,000 mg/ kg by the oral route. In a fertility and early embryonic development study in rats, besifloxacindid not impair the fertility of male or female rats at oral doses of up to 500 mg/kg/day. This is over 10,000 times higher than the recommended total daily human ophthalmic dose.14 CLINICAL STUDIESIn a randomized, double-masked, vehicle controlled, multicenter clinical trial, in which patients 1-98 years of age were dosed 3 times a day for 5 days, Besivance™ was superior to its vehicle in patients with bacterial conjunctivitis. Clinical resolution was achieved in 45% (90/198) for the Besivance™ treated group versus 33% (63/191) for the vehicle treated group (difference 12%, 95% CI 3% - 22%). Microbiological outcomes demonstrated a statistically significant eradication rate for causative pathogens of 91% (181/198) for the Besivance™ treated group versus 60% (114/191) for the vehicle treated group (difference 31%, 95% CI 23% -40%). Microbiologic eradication does not always correlate with clinical outcome in anti-infective trials.16 HOW SUPPLIED/STORAGE AND HANDLINGBesivance™ (besifloxacin ophthalmic suspension) 0.6%, is supplied as a sterile ophthalmic suspension in a white low density polyethylene (LDPE) bottle with a controlled dropper tip and tan polypropylene cap. Tamper evidence is provided with a shrink band around the cap and neck area of the package.5 mL in 7.5 mL bottleNDC 24208-446-05Storage: Store at 15°- 25°C (59° - 77°F). Protect from Light.Invert closed bottle and shake once before use.Rx Only17 PATIENT COUNSELING INFORMATIONPatients should be advised to avoid contaminating the applicator tip with material from the eye, fingers or other source.Although Besivance™ is not intended to be administered systemically, quinolones administered systemically have been associated with hypersensitivity reactions, even following a single dose. Patients should be advised to discontinue use immediately and contact their physician at the first sign of a rash or allergic reaction.Patients should be told that although it is common to feel better early in the course of the therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Besivance™ or other antibacterial drugs in the future.Patients should be advised not to wear contact lenses if they have signs or symptoms of bacterial conjunctivitis or during the course of therapy with Besivance™.Patients should be advised to thoroughly wash hands prior to using Besivance™.Patients should be instructed to invert closed bottle (upside down) and shake once before each use. Remove cap with bottle still in the inverted position. Tilt head back, and with bottle inverted, gently squeeze bottle to instill one drop into the affected eye(s). MANUFACTURER INFORMATIONManufactured by: Bausch & Lomb IncorporatedTampa, Florida 33637©Bausch & Lomb IncorporatedU.S. Patent No. 6,685,958U.S. Patent No. 6,699,492U.S. Patent No. 5,447,926Besivance™ is a trademark of Bausch & Lomb Incorporated*DuraSite is a trademark of InSite Vision IncorporatedApril 20099142602 (flat)9142702 (folded)PACKAGE/LABEL PRINCIPAL DISPLAY PANELNDC 24208-446-05Bausch & LombBesivancebesifloxacin ophthalmic suspension, 0.6%Rx onlySterileFOR OPHTHALMIC USE ONLY.5 mL。
The nature of the X-ray source in NGC 4151
a r X i v :a s t r o -p h /9601045v 1 10 J a n 1996The nature of the X-ray source in NGC 4151P.Magdziarz 1and A.A.Zdziarski 21Jagiellonian University,Astronomical Observatory,Orla 171,30-244Cracow,Poland 2N.Copernicus Astronomical Center,Bartycka 18,00-716Warsaw,Poland Abstract.Analysis of broad-band X/γ-ray spectra of NGC 4151shows that the data are well modelled with an intrinsic spectrum due to thermal Comptonization with temperature ∼50keV and X-ray spectral index α∼0.4–0.7.The variable X-ray spectrum pivots at ∼100keV,which is consistent with the observed approximatly con-stant γ-ray spectrum.The observed UV/X-ray correlation can be explained by two specific models with reprocessing of X-rays by cold matter.The first one is based on ree-mission of the X-ray flux absorbed by clouds in the line of sight.The second assumes reprocessing of X-rays and γ-rays by a cold accretion disk with a dissipative patchy corona.parison of the transmission model prediction with the IUE/EXOSAT data.The crosses give theflux F abs ab-sorbed by the cold matter obtained from EXOSAT data,andEF E(8.5eV)from IUE.The solid line gives EF E(8.5eV)as afunction of F abs from the transmission model.band spectra.The second model assumes reprocessing ofX-rays andγ-rays by a cold,optically-thick accretion diskwith dissipative patchy corona.The absorbed radiation is reemitted locally in UV as a blackbody.The homogeneouscorona model is ruled out because the hardness of the X-ray spectrum implies that the plasma is photon starved.Our second model predicts Compton reflection marginallyallowed by the observations.Both models satisfy the en-ergy balance and provide goodfits to the X/γ-rays andUV data.The transmission model(Fig.2)predicts:F UV= fF abs+F0where F UV is the integrated UVflux,F0=0.05keV cm−2s−1is a residual UVflux,and the factorf=0.60takes into account incomplete covering of the X-γsource by the clouds as well as an efficiency of theabsorbedflux conversion into the blackbody continuum. We determined the temperature of the absorber as kT≃3eV from the average observed spectral index in the UVbetween8.5and7.2eV(α=-0.15;Perola&Piro1994). The typical column density of a cloud in the partial cover-ing absorber is N H≃1023cm−2with the typical covering factor of≃0.5.The size of a single cloud is r c<∼107.The average size of the entire absorber is∼1014cm,whichsatisfy the limit r<∼1015cm from the relative UV/X-ray time delay(Warwick et al.1995).The parameters of the absorber are similar to those studied by Ferland&Rees (1988)and Guilbert&Rees(1988).In the reflection model we assume that all dissipationtakes place in the corona(e.g.Svensson&Zdziarski1994).We integrate the blackbody emission over the disk surface with the standard disk dissipation rate(Shakura&Sun-yaev1973).This relates the observed8.5eVflux to the total UVflux as a function of r Sµ1/2,where r S is the Schwarzschild radius,andµis a cosine of the disk incli-nation angle.The model predicts F UV=2(1−A)µRF Xγ,where A is an albedo for the total X-γflux,F Xγ,and R isa ratio of the corona emission intercepted by the disk to the luminosity emitted pton reflection forR<0.5is consistent with the broad-band spectra.We find that all0<r S<2.4×1012cm(or equivalentlyµR>∼0.15)fit the UV spectral indices(Fig.3).The value of r S=1.3×1012cm(forµR=0.21)provides the bestfit to UVfluxes.parison of the reflection model predictions with the data.(a)Crosses give the total UVflux F UV from ree-mission of the absorbed X-γflux as obtained extrapolating the EXOSAT X-ray power laws toγ-rays assuming thermal Comptonization at kT=60keV,R=0.5,andµ=0.42(from HST observations,Evans et al.1993).The curves relate the to-tal F UV to EF E(8.5eV),as predicted by the disk spectrum for various Schwarzchild radii r S.(b)Crosses give the UV spectral indices(Ulrich et al.1991).Curves give the indices predicted by the disk-corona model.ReferencesEvans I.N.,et al.,1993,ApJ417,82Ferland G.J.,Rees M.J.,1988,ApJ332,141Guilbert P.W.,Rees M.J.,1988,MNRAS233,475Perola G.C.,et al.,1986,ApJ306,508Perola G.C.,Piro L.1994,A&A281,7Shakura N.I.,Sunyaev R.A.,1973,A&A24,337Svensson R.,Zdziarski A.A.,1994,ApJ436,599Titarchuk L.,Mastichiadis A.,1994,ApJ433,L33Ulrich M.-H.,et al.,1991,ApJ382,483Warwick R.S.,et al.,1995,in preparationWarwick R.S.,Done C.,Smith D.A.,1995,MNRAS275,1003 Yaqoob T.,et al.,1993,MNRAS262,435Zdziarski A.A.,Johnson N.W.,Magdziarz P.,1996MNRAS submittedZdziarski A.A.,Magdziarz P.,1996MNRAS submitted。
X-ray observations of distant lensing clusters
a r X i v :a s t r o -p h /9706240v 1 24 J u n 1997X-RAY OBSER V ATIONS OF DISTANT LENSING CLUSTERSS.Schindler Max-Planck-Institut f¨u r extraterrestrische Physik,Giessenbachstraße,85740,Garch-ing,Germany Max-Planck-Institut f¨u r Astrophysik,Karl-Schwarzschild-Straße 1,85740,Garching,Germany Abstract X-ray observations of three clusters are presented:RXJ1347.5-1145,Cl0939+47,and Cl0500-24.Although these clusters are the in same redshift range (0.32-0.45)and act all as gravitational lenses,they show very different properties.RXJ1347.5-1145seems to be an old,well relaxed system,with a relaxed morphology,high X-ray luminosity,high temperature,high metallicity and strong cooling flow.The other two clusters have the appearance of young systems with substructure and low X-ray luminosity.The optical and X-ray luminosity shows hardly any correlation.A comparison with nearby clusters shows that many properties –like e.g.the metallicity or the amount of subclustering –show a large scatter and no clear trend with time.1Introduction Distant clusters are important objects to test cosmological models.A comparison of the proper-ties of distant clusters with the ones of nearby clusters gives insight when and how the evolution took place.Here we present the X-ray properties of three relatively distant clusters in the redshift range of 0.32-0.45.All show a gravitational lensing effect.RXJ1347.5-1145and Cl0500-24show brightarcs (Schindler et al.1995;Giraud 1988),Cl0939+47shows a weak lensing signal (Seitz et al.1996).The presence of a gravitational lensing signal means that they must be all massive clusters.From these characteristics one might expect that they are similar in other properties,too.But already the way how they are detected shows that they are by far not similar.While Cl0939+47and Cl0500-24were detected optically (Cl0939+47is actually the most distant Abell cluster),RXJ1347.5-1145was detected in X-rays in the ROSAT All Sky Survey.In the following we will show that also their X-ray properties are very different.2The most luminous X-ray cluster RXJ1347.5-1145For the analysis of RXJ1347.5-1145we use a ROSAT/HRI observation (see Fig.1)of 15760seconds and an ASCA observation of 58300seconds.These data reveal several extreme cluster properties.The X-ray luminosity of RXJ1347.5-1145is with 7.3±0.8×1045erg/s in the ROSAT band (0.1-2.4keV)or 2.1±0.4×1046erg/s bolometric the highest luminosity of a cluster found so far.MIDAS version: 95NOV Mo, 19 Aug 1996 15:23:28110809Figure 1:ROSAT/HRI contours of RXJ1347.5-1145superposed on an R image taken at the NTT.The two images are aligned in such a way that the positions of the X-ray maximum and the central galaxy correspond.The X-ray image is smoothed with a Gaussian filter of σ=2.5arcsec.The contours are linearly spaced with ∆countrate =0.032counts/s/arcmin 2the highest contour line corresponding to 0.54counts/s/arcmin 2.The positions of the arcs and arc candidates are marked with letters.The size of the image is 1.4×1.4arcmin 2(North is up,East is left).In the ASCA spectrum (Fig.2)an Fe line can be detected.It corresponds to a metallicity of 0.33±0.10in solar units.As this is a typical value for nearby clusters,it is quite surprising to find it in such a relatively distant cluster.From the ASCA spectrum we can also determine the temperature.With 9.3+1.1−1.0keV RXJ1347.5-1145is a relatively hot cluster.The strongly peaked emission (see Fig.1)suggests the presence of a cooling flow.We findFigure2:Spectrum of both GIS detectors within a6.4arcminute radius.Around5keV the (redshifted)FeK line is visible,which corresponds to a metallicity of0.33in solar units.Afit with a Raymond-Smith model(solid line)and the residuals are shown.a central cooling time of1.2×109yr.With the standard assumptions we derive a cooling flow radius of29arcseconds(200kpc)and a mass accretion rate of more than3000M⊙/yr. Obviously,RXJ1347.5-1145is also in terms of coolingflow an extreme.Such a strong cooling flow suggests that was no merging recently.Otherwise it would have disrupted the coolingflow or at least decreased the mass accretion rate.For a comparison of lensing and X-ray masses we calculate the surface mass density from the X-ray data at the radius of the arcs,2.1×1014M⊙.The lensing mass is still preliminary because the redshift of the arcs are only estimated and the lens model is very simple.For a redshift range of z=0.7-1.2,wefind a lensing mass of4.4-7.8×1014M⊙.This discrepancy can be removed with a better lens model.Summarizing,although RXJ1347.5-1145is a distant cluster,it shows the properties of a well evolved,old system:spherically symmetric morphology,high luminosity,high temperature,high metallicity,and obviously no merging in the recent past because of the huge coolingflow(see Table1).For more details see Schindler et al.(1997).3The optically rich cluster Cl0939+47Cl0939+47is an extremely rich,optically well studied cluster(Dressler&Gunn1992).For the X-ray analysis we use a ROSAT/PSPC observation of14350ksec.Fig.3shows the ROSAT/PSPC image of Cl0939+47.It has the appearance of a non-virialized cluster.It is not centrally peaked like RXJ1347.5-1145but shows substructure.There are three maxima visible.Ellipsefits to different isophote levels yield ellipticities up to0.75.The X-ray luminosity is with7.9±0.3×1044erg/s(0.1-2.4keV)rather on the low sidekeV,is for such a rich cluster.Also the temperature derived from the PSPC spectrum,2.9+1.3−0.8 relatively low.Figure3:ROSAT/PSPC image of the cluster CL0939+4713in the ROSAT hard band(0.5-2.0 keV).The data are smoothed with a Gaussianfilter ofσ=15arcsec.Three maxima(M1,M2, M3)and a probable foreground point source(P1)are marked.A mass comparison is difficult for this cluster because,firstly,the weak lensing mass was determined only in the L-shaped region from an HST/WFPC observation(Seitz et al.1996) and the X-ray mass estimate has a large error because spherical symmetry has to be assumed, which is not a good approximation for this cluster.But it seems that the X-ray mass is about a factor of three smaller than the lensing mass.All the X-ray properties of Cl0939+47(substructure,low X-ray luminosity,low temperature) as well as the large fraction of post-starburst galaxies(Belloni et al.1995)point to a young, non-relaxed system(for details see Schindler&Wambsganss1996).corner is not associated with the cluster.Superposed on the contours are cluster galaxies assigned to the subclusters N and C by Infante et al.(1994).Triangles:galaxies assigned to subcluster C, squares:galaxies assigned to subcluster N.One tickmark corresponds to10arcseconds or57kpc. The contour levels have a linear spacing of3.8×10−4counts/s/arcmin2.The highest contour corresponds to9.2×10−3counts/s/arcmin2,the lowest to5.0×10−3counts/s/arcmin2.The central galaxies of the subclusters are marked with N and C,respectively.The X-ray emission is well correlated with the subcluster centred on N,while there is hardly any correlation with the C subcluster.In particular,there is no extra emission at the position of the central galaxy C.4Cl0500-24:a cluster with two subclusters in the line of sightThe cluster Cl0500-24is similar to Cl0939+47in many respects.It is also an optically rich cluster,which shows substructure.The substructure is not only found in the ROSAT/HRI image(Fig.4),but also in the velocity distribution of the cluster galaxies(Infante et al.1994): they found two subclusters with a relative velocity of about3000km/s.A comparison of the spatial distribution of the subcluster galaxies and the X-ray emission (Fig.4)suggests that only one of the subclusters is X-ray luminous,the subcluster around galaxy N.This is an indication that the N subcluster is massive.The C subcluster,however, must be massive as well,because the arc has its curvature towards galaxy C.Obviously,there are two components in this cluster which have a very different gas content.erg/s,is surprisingly low for such a rich cluster.Thisfits well The X-ray luminosity,3.1+0.6−0.4with the assumption that only part of the cluster is X-ray luminous.An X-ray mass estimate yields a smaller mass than the lensing mass model by Wambsganss et al.(1989).With the new ASCA temperature(Ota et al.1997;see also Mitsuda,this volume)the X-ray mass is0.5×1014M⊙at22arcmin while the lensing model gives a mass of1.4×1014M⊙at the same radius.This discrepancy can be explained easily if one assumes that the cluster consists of two subclusters,out of which only one is X-ray luminous.The X-ray measurement traces only the potential wellfilled with gas,while lensing is sensitive to all the mass along the line of sight.Furthermore,a discrepancy can arise because the two mass estimates have different centres:the X-ray mass is centred on the X-ray maximum(i.e.close to galaxy N)while the mass model is centred close to galaxy C.Summarizing,Cl0500-24shows the characteristics of a young system:it has substructure and a low X-ray luminosity(for more details see Schindler&Wambsganss1997).Table1:Comparison of the X-ray properties of the three clusters.For determining the X-ray mass of Cl0500-24the ASCA temperature(Ota et al.1997;see also Mitsuda,this volume),7.2 keV,is used.RXJ1347.5-1145Cl0500-24 redshift0.41×10447.3±0.8×10457.9+0.6−0.4r c[kpc]11000.560.36 metallicity(solar)-2.0×1014M⊙0.5×1014M⊙×1014M⊙M tot(<1Mpc)2.6+1.2−0.630-40%12-25% coolingflow radius-1.2×109yr-mass accretion rate-5ConclusionsAlthough the presented clusters are all massive and at about the same distance,they are by far not similar.Some have the appearance of young systems,still far away from virial equilibrium (Cl0939+47,Cl0500-24),others seem to be already quite old systems(RXJ1347.5-1145).This difference is not only evident from the amount of substructure but also from the X-ray luminosity, the gas temperature or the metallicity(see Tables1and2).These three clusters show hardly any correlation of optical and X-ray luminosity.Table2:Comparison of nearby and distant clusters.a from Neumann&B¨o hringer(1997),b from Hattori et al.(1997),c from Ota et al.(1997),see also Mitsuda this volume,d from Tsuru et al.(1996),e from Neumann(1997)Cl0500-24RXJ1347AXJ2019b0.410.550.05-5 1.1 5.00.2-0.5small small2-10 2.98.2din25%e yes yesSchindler,S.,Wambsganss,J.1996,A&A,313,113Schindler,S.,Wambsganss,J.1997,A&A,322,66Schindler,S.,Hattori,M.,Neumann,D.M.,B¨o hringer,H.1997,A&A,317,646Seitz,C.,Kneib J.-P.,Schneider P.,Seitz,S.1996,A&A,314,707Tsuru,T.,Koyama,K.,Hughes,J.P.,Arimoto,N.,Kii,T.,Hattori,M.1996,in UV and X-Ray Spectroscopy of Astrophysical and Laboratory Plasmas,ed.K.Yamashita K.and T.Watanabe(Tokyo:Universal Academic Press),375Wambsganss,J.,Giraud,E.,Schneider,P.,Weiss,A.1989,ApJ,337,L73。
SuperWASP Observations of the Transiting Extrasolar planet XO-1b
a r X i v :a s t r o -p h /0607591v 1 26 J u l 2006SuperW ASP Observations of the Transiting Extrasolar planetXO-1bD.M.Wilson 1,B.Enoch 2,D.J.Christian 3,W.I.Clarkson 2,4,A.Collier Cameron 5,H.J.Deeg 6,A.Evans 1,C.A.Haswell 2,C.Hellier 1,S.T.Hodgkin 7,K.Horne 5,J.Irwin 7,S.R.Kane 5,8,T.A.Lister 5,1,P.F.L.Maxted 1,A.J.Norton 2,D.Pollacco 3,I.Skillen 9,R.A.Street 3,R.G.West 10,P.J.Wheatley 11ABSTRACT We report on observations of 11transit events of the transiting extrasolar planet XO-1b by the SuperWASP-North observatory.From our data,obtained during May-September 2004,we find that the XO-1b orbital period is 3.941634±0.000137days,the planetary radius is 1.34±0.12R Jup and the inclination is 88.92±1.04◦,in good agreement with previously published values.We tabulate the transit timings from 2004SuperWASP and XO data,which are the earliest obtained for XO-1b,and which will therefore be useful for future investigations of timing variations caused by additional perturbing planets.We also present an ephemeris for the transits.Subject headings:Stars:planetary systems1http://exoplanet.eu/2Southern hemispheres.SuperWASP-North (SW-N)is based on La Palma,Canary Islands,andSuperWASP-South (SW-S)is based at SAAO,South Africa.Both observatories consist of 8cam-eras,each with an 11.1cm aperture Canon 200mm f/1.8lens backed by a 2k ×2k EEV CCD.Each camera has a field of view of 7.8×7.8degrees with a 13.7′′/pix plate scale,resulting in a total field of view of almost 500square degrees per observatory.Further details of the project are given in Pollacco et al.(2006).The SW-N observatory obtained nearly 4500in-dividual observations of XO-1over 150days be-tween 2May 2004to 29September 2004.The object was recorded by two cameras producing a total of 8875measurements.The photometric pre-cision,when outliers from cloudy nights are ex-cluded,is approximately 9mmags (RMS).This is slightly worse than usual for stars of this magni-tude owing to the close proximity to the edges of the camera fields.Lightcurves from SuperWASP are de-trendedusing the algorithm of Tamuz et al.(2005)beforebeing passed through hunter (Collier Cameronet al.2006),a transit search algorithm based onthe method of Protopapas et al.(2005).The algorithm computes χ2values of transit modellightcurves using a box-shaped model slid overthe observed lightcurve.Typically,a few tensof transit-like lightcurves are identified from each CCD field of 10-20,000objects.The hunter output for XO-1(1SWASP J160211.83+281010.4)is shown in Figure 1.The periodogram showsthe value of χ2for the best least-squares fit ateach frequency;the de-trended lightcurve is phase-folded on the best fitting period of 3.942134days.hunter listed this object as a high priority can-didate to be considered for further investigation.3.Lightcurve FittingThe SW-N data covers 11transit events and,excluding outliers,consists of 8468datapoints.The transits were fitted to a simulated planetary transit generated using ebop (Eclipsing Binary Orbit Program;Popper &Etzel (1981)).ebop uses biaxial ellipsoids to simulate eclipsing binary star systems;however,by considering the sec-ondary as an opaque disc,a transiting planetarysystem can easily be modelled.The simulatedlightcurve is dependent upon the radii ratio of thetransiting planet to the parent star R pl /R ⋆,the inclination of the transiting planet’s orbit,i p ,and the limb-darkening coefficient of the star.The limb-darkening coefficient was determined by convolving the SuperWASP bandpass with fluxes and monochromatic coefficients listed by Van Hamme (1993).A linear limb-darkening co-efficient of 0.565was calculated for the stellar tem-perature of 5750K (G1V)quoted by McCullough et al.(2006).The best-fit parameters determined from a least-squares fit to all transits simultaneously are listed in Table 1.Figure 2shows the data phase-folded on the best-fitting period with the best-fit model overplotted.The original XO survey data (Peter McCullough,private communication),ob-tained on a similar instrument to SW-N,are also shown for comparison.The errors were generated using a boot-strap Monte Carlo method in which we generated and re-fit 1000simulated data setsfrom the best-fit lightcurve with the same sam-pling and noise characteristics as the observed lightcurve.The planetary radius was determined from the ratio R pl /R ⋆by using the stellar radius of 1.0±0.08R ⊙determined spectroscopically by McCullough et al.(2006).The parameters deter-mined from the fit are consistent with previously published values (McCullough et al.2006).11transit events were identified from the de-termined period and ephemeris and the best-fitmodel was fitted to each of these individually to determine the time of mid-transit T 0(Table 2).The best fit model was also fitted to the XO survey data which cover 3transit events and were also ob-tained in 2004.Three of the total fourteen transits were rejected either due to insufficient coverage of the transit event,or in one case the data being too noisy to produce an adequate fit.The errors weregenerated by perturbing T 0so as to increase χ2by one and are typically of the order 5-10mins,which is comparable to the data sampling rate.This paper has demonstrated that SuperWASP can detect and characterise exoplanet transits and obtain sufficient data to determine an ephemeris.Other candidate exoplanet transits from our 2004data will be reported in subsequent papers.4.AcknowledgementsThe WASP consortium consists of representa-tives from the Universities of Cambridge(Wide Field Astronomy Unit),Keele,Leicester,The Open University,Queen’s University Belfast and St Andrews,along with the Isaac Newton Group (La Palma)and the Instituto de Astrophysic de Canarias(Tenerife).The SuperWASP-N and SuperWASP-S Cameras were constructed and op-erated with funds made available from Consortium Universities and PPARC.We are grateful to the XO team for making available the original XO photometry. REFERENCESCollier Cameron,A.et al.,2006,MNRAS,Sub-mittedMcCullough,P.R.,et al.,2006,ApJ,In-Press Pollacco,D.,et al.,2006,PASP,Submitted Popper,D.M.,Etzel,P.B.,1981,AJ,86,102 Protopapas,P.,Jimenez,R.,Alcock,C.,2005, MNRAS,362,460Tamuz,O.,Mazeh,T.,Zucker,S.,2005,MNRAS, 356,1466Van Hamme,W.,1993,AJ,106,2096Table1:Bestfitting parameters of XO-1from the fit of the SW-N data.Parameter SW-Na From McCullough et al.(2006)Table2:Best-fit times of mid-transit for full and partial XO-1b transits from SW-N and XO survey data.Observatory HJD(mid-transit)Transit N XO2453123(no-fit)bXO2453127.0385±0.0058(partial)32 XO2453142.7818±0.0218(partial)40 SW-N2453146(no-fit)bSW-N2453150.6855±0.0106(partial)88 SW-N2453154.6250±0.0026(full)99 SW-N2453158.5663±0.0034(full)102 SW-N2453162.5137±0.0025(full)117 SW-N2453166.4505±0.0025(partial)68 SW-N2453170.3917±0.0037(partial)65 SW-N2453229.5143±0.0045(partial)54 SW-N2453233(no-fit)bSW-N2453237.4043±0.0032(partial)47 SW-N2453241.3410±0.0067(partial)38Fig. 1.—Hunter output for object 1SWASPJ160211.83+281010.4(camera2)in-cluding periodogram and lightcurve folded on the Hunter determined best-fitting period of3.942134 days.Fig. 2.—SuperWASP-North data(upper panel) and XO survey data(lower panel)for XO-1phase folded on the bestfitting parameters listed in Ta-ble1with the best-fit model over-plotted.。
胚胎诱导
组织者:能够诱导外胚层形成神经系统,并能和 其他组织一起调整成为中轴器官的胚孔背唇部分。
二、初级胚胎诱导各阶段细胞间相互作用
初级胚胎诱导=神经诱导(neural induction)?
初级诱导的三个阶段(爪蟾为例)
(一)中胚层的形成和分区(卵裂期)
(二)神经诱导--脊索诱导背部外胚层形成神经外胚 层并进一步分化
(三)中枢神经系统的区域化
Figure 10.20. Organization of a secondary axis by dorsal blastopore lip tissue. (A) Dorsal lip tissue from an early gastrula is transplanted into another early gastrula in the region that normally becomes ventral epidermis. (B) The donor tissue invaginates and forms a second archenteron, and then a second embryonic axis. Both donor and host tissues are seen in the new neural tube, notochord, and somites. (C) Eventually, a second embryo forms that is joined to the host. (D) Structure of the dorsal blastopore lip region in an early Xenopus gastrula. (A-C after Hamburger 1988; D after Winklbauer and Schürfeld 1999 and Arendt and Nü blerJung 1999.)
开启片剂完整性的窗户(中英文对照)
开启片剂完整性的窗户日本东芝公司,剑桥大学摘要:由日本东芝公司和剑桥大学合作成立的公司向《医药技术》解释了FDA支持的技术如何在不损坏片剂的情况下测定其完整性。
太赫脉冲成像的一个应用是检查肠溶制剂的完整性,以确保它们在到达肠溶之前不会溶解。
关键词:片剂完整性,太赫脉冲成像。
能够检测片剂的结构完整性和化学成分而无需将它们打碎的一种技术,已经通过了概念验证阶段,正在进行法规申请。
由英国私募Teraview公司研发并且以太赫光(介于无线电波和光波之间)为基础。
该成像技术为配方研发和质量控制中的湿溶出试验提供了一个更好的选择。
该技术还可以缩短新产品的研发时间,并且根据厂商的情况,随时间推移甚至可能发展成为一个用于制药生产线的实时片剂检测系统。
TPI技术通过发射太赫射线绘制出片剂和涂层厚度的三维差异图谱,在有结构或化学变化时太赫射线被反射回。
反射脉冲的时间延迟累加成该片剂的三维图像。
该系统使用太赫发射极,采用一个机器臂捡起片剂并且使其通过太赫光束,用一个扫描仪收集反射光并且建成三维图像(见图)。
技术研发太赫技术发源于二十世纪九十年代中期13本东芝公司位于英国的东芝欧洲研究中心,该中心与剑桥大学的物理学系有着密切的联系。
日本东芝公司当时正在研究新一代的半导体,研究的副产品是发现了这些半导体实际上是太赫光非常好的发射源和检测器。
二十世纪九十年代后期,日本东芝公司授权研究小组寻求该技术可能的应用,包括成像和化学传感光谱学,并与葛兰素史克和辉瑞以及其它公司建立了关系,以探讨其在制药业的应用。
虽然早期的结果表明该技术有前景,但日本东芝公司却不愿深入研究下去,原因是此应用与日本东芝公司在消费电子行业的任何业务兴趣都没有交叉。
这一决定的结果是研究中心的首席执行官DonArnone和剑桥桥大学物理学系的教授Michael Pepper先生于2001年成立了Teraview公司一作为研究中心的子公司。
TPI imaga 2000是第一个商品化太赫成像系统,该系统经优化用于成品片剂及其核心完整性和性能的无破坏检测。
X-ray Absorption Spectroscopy (XAS)
X-ray Absorption Spectroscopy (XAS)When the x-rays hit a sample, the oscillating electric field of the electromagnetic radiation interacts with the electrons bound in an atom. Either the radiation will be scattered by these electrons, or absorbed and excite the electrons.xA narrow parallel monochromatic x-ray beam of intensity I 0 passing through a sample of thickness x will get a reduced intensity I according to the expression: ln (I 0 /I) = µ x (1)where µ is the linear absorption coefficient , which depends on the types of atoms and the density ρ of the material. At certain energies where the absorption increases drastically, and gives rise to an absorption edge . Each such edge occurs when the energy of the incident photons is just sufficient to cause excitation of a core electron of the absorbing atom to a continuum state, i.e . to produce a photoelectron. Thus, the energies of the absorbed radiation at these edges correspond to the binding energies of electrons in the K, L, M, etc, shells of the absorbing elements. The absorption edges are labelled in the order of increasing energy , K, L I , L II , L III , M I ,…., corresponding to the excitation of an electron from the 1s (2S ½), 2s (2S ½), 2p (2P ½), 2p (2P 3/2), 3s (2S ½), … orbitals (states), respectively. Bohr Atomic Modeled K L L L Continuumge: 2 S ½2P ½2P 32IIIII IWhen the photoelectron leaves the absorbing atom, its wave is backscattered by the neighbouring atoms. The figure below shows the sudden increase in the x-ray absorption of the platinum Pt L III edge in K 2[Pt(CN)4] with increasing photon energy. The maxima and minima after the edge correspond to the constructive and destructive interference between the outgoing photoelectron wave and backscattered wave. 11300115001170011900121001230012500Energy (eV)µ (E )An x-ray absorption spectrum is generally divided into 4 sections: 1) pre-edge (E < E 0); 2) x-ray absorption near edge structure (XANES ), where the energy of the incident x-ray beam is E = E 0 ± 10 eV; 3) near edge x-ray absorption fine structure (NEXAFS ), in the region between 10 eV up to 50 eV above the edge; and 4) extended x-ray absorption fine structure (EXAFS ), which starts approximately from 50 eV and continues up to 1000 eV above the edge.The minor features in the pre-edge region are usually due to the electron transitions from the core level to the higher unfilled or half-filled orbitals (e.g, s → p , or p → d ). In the XANES region, transitions of core electrons to non-bound levels with close energy occur. Because of the high probability of such transition, a sudden raise of absorption is observed. In NEXAFS, the ejected photoelectrons have low kinetic energy (E-E 0 is small) and experience strong multiple scattering by the first and even higher coordinating shells. In the EXAFS region, the photoelectrons have high kinetic energy (E-E 0 is large), and single scattering by the nearest neighbouring atoms normally dominates.11400.00.51.01.52.001150011600117001180011900Multiple scatteringSingle scatteringHome Research Publications Synchrotron XANES EXAFS XAS Measurement。
and
G. V. Jung
Accepted for publication in the Astrophysical Journal
ABSTRACT
The Oriented Scintillation Spectrometer Experiment on the Compton Gamma Ray Observatory observed the Galactic black hole candidate GX 339?4 as a target of opportunity in 1991 September, in response to the outburst reported by BATSE. We report here on energy spectra in the 50 keV to 10 MeV range obtained by OSSE. The source was detected from 50 to 400 keV at a level relative to the Crab nebula of 30%. The observed spectrum was described reasonably well by a power law with an exponential cuto ; a least-squares t yielded a photon index of :88 :05 and a cuto energy of (68 2) keV. The addition of a Compton re ection component did not signi cantly improve the overall t. An optically-thin thermal bremsstrahlung spectrum also provides a good t, and the thermal Comptonization model of Sunyaev and Titarchuk, while de cient in describing the data above about 200 keV, cannot formally be ruled out. A pure power law with re ection does not t the observed spectrum. During a follow-up observation made in 1991 November, the intensity of the source below 100 keV
Poincare-Bendixson-Theorem
Be trapped inside a set or not
Consider a simple closed curve defined by the equation V(x)=c, where V(x) is continuously differentiable.The vector field f(x) points inward if f(x)・∇V (x)<0; points outward if f(x)・∇V (x)>0; and it is tangent to the curve if f(x)・∇V (x)=0.
9
Proof of Lemma1
▪ It cannot return to any other point on L between A and B either, so if it ever crosses L again, it will have to be further along in the same direction on L, as in the point C indicated in the figure.
17
Proof of Poincare-Bendixson Theorem
• If the orbit through x is not closed, it must pass close enough to z that it must cross L, infinitely often in a sequence that approaches z from one side.
Furthermore, if it crosses several times, the crossing points are ordered along line in the same way as on the orbit itself.
浅谈松材线虫病的危害及防治措施
文章编号:1673-887X(2023)04-0114-03浅谈松材线虫病的危害及防治措施甘小芳(贵港市覃塘林场,广西壮族自治区贵港537100)摘要松材线虫病是危害松树林带的重要病害,防治不当对松树林带将会造成毁灭性打击,阻碍林业经济发展,影响森林生态。
文章以松材线虫病的危害为切入点,简单阐述松材线虫病存在感染速度快、致死率高、检测难度大的危害因素,以此为基础,结合松材线虫病的监测方案,提出物理防治、化学防治、生物防治、营林防治的四种防治措施,从而为相关工作者提供参考。
关键词松树;松材线虫病;危害;防治措施中图分类号S436文献标志码Adoi:10.3969/j.issn.1673-887X.2023.04.043Discussion on the Harm and Prevention Measures of Bursaphelenchusxylophilus (SteineretBuhrer)Gan Xiaofang(Qintang Forest Farm of Guigang City,Guigang 537100,Guangxi Zhuang Autonomous Region,China)Abstract :Bursaphelenchusxylophilus (SteineretBuhrer)is an important disease that endangers the pine forest belt.Improper preven ‐tion and control will cause a devastating blow to the pine forest belt,hinder the development of forestry economy and affect the for ‐est ecology.This paper took the harm of Bursaphelenchusxylophilus (SteineretBuhrer)as the starting point,and briefly expounded the harm of Bursaphelenchusxylophilus (SteineretBuhrer)that has fast infection rate,high mortality rate and great difficulty in detec ‐tion.On this basis,combined with the monitoring plan of Bursaphelenchusxylophilus (SteineretBuhrer),this paper put forward four prevention and control measures of physical control,chemical control,biological control and forest management,so as to provide ref ‐erence for relevant workers.Key words :pine,Bursaphelenchusxylophilus (SteineretBuhrer),harm,prevention and control measures松材线虫病也称为松树萎蔫病,是线虫感染引发的侵染性系统病害。
Human babesiosis
Human BabesiosisEdouard Vannier,PhD a ,Benjamin E.Gewurz,MD,PhD b ,Peter J.Krause,MD c ,d ,*aDivision of Geographic Medicine and Infectious Diseases,Tufts Medical Center,Tufts University School of Medicine,800Washington Street,Boston,MA 02111,USAb Brigham and Women’s Hospital,Division of Infectious Diseases,75Francis Street,Harvard Medical School,Boston,MA 02115,USAc University of Connecticut School of Medicine,263Farmington Avenue,Farmington,CT 06030,USAd Division of Infectious Diseases,Connecticut Children’s Medical Center,282Washington Street,Hartford,CT 06106,USA Human babesiosis is an emerging tick-borne infectious disease caused by protozoa of the genus Babesia that are obligate parasites of red blood cells.Long recognized as pathogens imposing a significant health burden on domesticated animals,Babesia sp increasingly have been identified over the last 50years as a cause of infection in people throughout the world.The first reference to babesiosis is probably in Exodus 9:3,which de-scribes the plague visited upon the cattle of Pharaoh Rameses II.Viktor Babes [1],a Hungarian pathologist who investigated the cause of febrile he-moglobinuria in cattle first described the babesial microorganism in 1888and it was named after him in honor of his discovery.Shortly thereafter,Smith and Kilborne [2]identified a similar organism in Texas cattle (later recognized as Babesia bigemina )and identified the cattle tick Boophilus annulatus as the vector.This seminal observation constituted the first evi-dence that an arthropod could transmit an infectious agent to a vertebrate host.More than 100species of Babesia subsequently have been identified in wild and domestic animals [3].This work was supported by grants AG19781(E.V.)and RR06192(P.J.K.)from the National Institutes of Health.Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the National Institutes of Health.*Corresponding author.Division of Infectious Diseases,Connecticut Children’s Medical Center,282Washington Street,Hartford,CT 06106.E-mail address:pkrause@ (P.J.Krause).0891-5520/08/$-see front matter Ó2008Elsevier Inc.All rights reserved.doi:10.1016/ Infect Dis Clin N Am22(2008)469–488470VANNIER et alThefirst human case of babesiosis was identified in1957near Zagreb, Croatia[4].A young farmer had been grazing cattle on tick-infested pastures and presented with fever,anemia,and hemoglobinuria.He was asplenic and died of renal insufficiency during the second week of illness.Initially reported as Babesia bovis,the agent most likely was Babesia divergens,another patho-gen of cattle.In1968,B divergens was confirmed as the etiologic agent in an asplenic person infected while vacationing in the Irish countryside[5].While these asplenic cases were attracting the attention of physicians in Europe,bab-esiosis was diagnosed in several residents of Nantucket Island offthe coast of Massachusetts.The causative agent was determined to be B microti,which typically infects mice and other small rodents[6].Spielman and colleagues [7–10]subsequently identified the vector as Ixodes dammini(also known as I scapularis)and recognized the white-tailed deer(Odocoileus virginianus)as an important natural host.Human babesiosis caused by B microti was subse-quently reported from endemic mainland sites in the northeastern and north-ern midwestern United States.Other babesial species(Babesia duncani and Babesia divergens-like organisms)were later recognized to cause babesiosis in the West and Midwest.Human babesiosis also has been reported from Asia,Africa,and South America.EpidemiologyThe pathogenBabesia sp belong to the phylum Apicomplexa,together with organisms that cause malaria(Plasmodium sp),toxoplasmosis(Toxoplasma gondii), and cryptosporidiosis(Cryptosporidium).The name Apicomplexa is derived from the complex of unique organelles located at the cellular apex of certain life stages of these protists.The apical complex includes vesicles called rhop-tries and micronemes that secrete enzymes allowing the parasite to invade host cells[11].Babesia sp have a complex life cycle that involves asexual reproduction in the erythrocytes of mammalian hosts and sexual reproduction in arthropod vectors(/dpdx/html/Babesiosis.htm).Within the red blood cell,trophozoites reproduce by budding rather than schizogony.B mi-croti and B duncani may undergo two successive divisions.The four resulting nuclei remain in close proximity,and this merozoite tetrad form is described as a‘‘Maltese cross.’’B divergens merozoites undergo a single division. Egress of merozoites and lysis of red blood cells appear to occur simulta-neously.Free merozoites in the bloodstream infect other red blood cells. Some of the host intraerythrocytic forms are gametocytes that contain twice as much DNA and are morphologically distinct from trophozoites[12,13]. Gametocytes ingested by ticks during the blood meal emerge from erythro-cytes within the gut and fuse to form an ookinete that penetrates the gut ep-ithelium.Ookinetes invade the tick salivary glands and other tissue,thentransform into sporoblasts that remain dormant through the molt of the en-gorged tick [14].When the next stage of the tick (nymph or adult)takes a blood meal from a vertebrate host,sporoblasts are activated and begin a sporogonic process.Each sporoblast may liberate up to 10,000sporozo-ites,which enter the salivary ducts of the tick and are deposited into the skin of the infested vertebrate [15].TransmissionBabesia microti is the most common cause of human babesiosis.The pri-mary tick vector of this species is Ixodes scapularis [10].The primary reservoir for B microti in the northeastern United States is the white-footed mouse (Per-omyscus leucopus )[7,10].As many as two thirds of mice have been found to be parasitemic in endemic areas [10].These mice also may be infected with Bor-relia burgdorferi ,the etiologic agent of Lyme disease,and Anaplasma phagocy-tophilum ,the agent of human granulocytic anaplasmosis.I scapularis may therefore acquire B microti ,B burgdorferi ,and A phagocytophilum during a blood meal and subsequently transmit one or more of these pathogens[10,16].Each of the three active stages in the life cycle of Ixodes scapularis (larva,nymph,and adult)takes a blood meal from a vertebrate host to mature to the next stage (Fig.1).The tick transmission cycle begins in the spring when adult females lay eggs that hatch into larvae.In the late summer,newly hatched larvae ingest the parasite when they take a blood meal from an in-fected rodent.Fed larvae subsequently molt to the nymphal stage.Nymphs transmit Babesia to rodents in late spring and summer of the following year[7,10].Larvae,nymphs,and adults can feed on humans,but nymphs are the primary vector [17].All active tick stages also feed on the white-tailed deer,which is an important host for the tick but is not a reservoir for B microti[10].Because deer serve to amplify the number of ticks,the growth of the deer population over the last few decades is thought to be the major cause for the increase in human cases [7,10,18].Babesiosis rarely is acquired through blood transfusion;a few cases of transplacental/perinatal transmis-sion have been described [19–21].Human epidemiologyOver the last 50years,the epidemiology of human babesiosis has changed from a few isolated cases to the establishment of endemic areas in southern New England,New York,and the north central Midwest.Human babesiosis caused by B microti has been reported in Connecticut,Massachusetts,Minne-sota,New Jersey,New York,Rhode Island,and Wisconsin [6–10,19,22–26].Moderate to severe illness caused by B duncani (WA1)occurs in northern Cal-ifornia and Washington State whereas cases of B divergens -like infection have been reported from Missouri,Kentucky,and Washington State [27–31].In Europe,human babesiosis is caused by B divergens ,B microti ,and EU1and 471HUMAN BABESIOSISis thought to be transmitted by Ixodes ricinus [32–37].EU1is a species closely related to B odocoilei and known to infect white-tailed deer.It was first iden-tified in 2003when two asplenic patients from the Tyrol region of Austria and the Alpine region of Italy developed a severe illness that was found to be caused by this new babesial species [34].In Asia,babesiosis has been reported in Japan (B.microti -like),Korea (KO1),Taiwan (TW1),and India [38–41].Human babesiosis also has been reported in Africa and South America[42,43].The number of reported cases of babesiosis is less than that of Lyme dis-ease [44].Although the babesial piroplasm and Lyme spirochete share the same reservoir hosts and tick vectors,human babesiosis has been recognized only in concentrated foci within Lyme disease–endemic areas.Furthermore,babesia are less commonly found in ticks and rodents than B burgdorferi within these foci [45].Unlike Lyme disease,babesiosis is not a nationally re-portable disease.Lyme disease is better recognized and moreeasilyFig.1.Life cycle of the Ixodes scapularis tick.(Courtesy of ler).472VANNIER et aldiagnosed than babesiosis,primarily because of the pathognomonic ery-thema migrans rash,whereas symptoms and signs of babesiosis are nonspe-cific and easily mistaken for a viral illness [46].Results of a detailed epidemiologic study of babesiosis and Lyme disease suggest that the dispar-ity in the frequency of these infections on the southern New England coast is markedly less than would be expected from the number of reported cases[44].The public health burden of babesiosis is incompletely described but may be significant in certain endemic sites.Nantucket Island reported 21cases in 1994,which translates to 280cases per 100,000inhabitants,placing the burden of disease in a category with gonorrhea as ‘‘moderately com-mon’’[47].Furthermore,babesiosis may be increasing in incidence relative to Lyme disease.Over the last decade,the incidence of B microti infection on Block Island,Rhode Island increased approximately four-fold while that of B burgdorferi remained unchanged [44].Most human cases of babesiosis oc-cur in the summer and in areas where the vector tick,rodents,and deer are in close proximity to humans [10].Although the majority of reported cases are adults,there is evidence that the disease is more common in children than previously thought [44].Clinical manifestationsPatients may experience a spectrum of disease severity.Three distinct syndromes have been described:(1)a mild-to-moderate viral-like illness,(2)severe disease with a fulminant course resulting in death or a persistent relapsing course,or (3)asymptomatic infection.Limited data suggest that symptoms of babesiosis begin 1to 6weeks after tick feeding.Mild-to-moderate illnessMost cases of babesiosis consist of a mild-to-moderate illness character-ized by the gradual onset of malaise and fatigue followed by intermittent fe-ver and one or more of the following:chills,sweats,headache,arthralgia,myalgia,anorexia,and cough (Table 1)[16,48–50].Less commonly noted are sore throat,abdominal pain,nausea,vomiting,weight loss,conjunctival injection,photophobia,pallor,emotional lability,depression,and hyperes-thesia [51,52].The findings on physical examination generally are minimal,often consisting only of fever [16,49].Mild splenomegaly,hepatomegaly,or both are noted occasionally [49,53].Slight pharyngeal erythema,jaundice,and retinopathy with splinter hemorrhages and retinal infarcts also have been reported [54,55].Rash seldom is noted,although ecchymoses and pe-techiae have been described in severe cases [52].The illness usually lasts for several weeks to months,occasionally with prolonged recovery that can last more than a year [16,49,56,57].Parasitemia may continue even after the patient feels well and rarely may persist for more than 2years after the initial episode [57].473HUMAN BABESIOSISSevere diseaseSevere disease generally occurs in persons with underlying immunosup-pressive conditions that include HIV coinfection [58–60],malignancy [56],immunosuppressive medication [56,61],and splenectomy [56,62,63].In a re-cent case-control study,patients with more than one of these immunosup-pressive conditions were shown to experience a prolonged relapsing course of illness,sometimes lasting more than a year [56].Despite multiple courses of antibabesial therapy,one fifth of these patients died.Persons aged 50years and older are also more likely to experience severe babesiosis [48,50].Recent studies using a babesia mouse model suggest that age related severity is genet-ically determined [64].Microbial virulence also may contribute to disease se-verity as B divergens and B duncani appear to cause more severe infection than B microti [31,65].Complications of babesiosis are commonly associated with severe illness and include acute respiratory failure,disseminated intravascular coagula-tion,congestive heart failure,liver and renal failure,and splenic infarction (Table 2).In a review of 34consecutive babesial patients admitted to the hospital (median age of 43years;range,3months to 85years),the most common complication was acute respiratory failure [48].Nine percent of these hospitalized patients died.A mortality rate of 5%was noted in a ret-rospective study of 136patients experiencing B microti infection on Long Is-land,New York [25].In that study,patients who suffered fatal infection ranged in age from 60to 82years,and only one was known to be immunocompromised.Asymptomatic infectionFollowing transmission of the babesial parasite,people experience asymptomatic infection during an incubation period that may last forTable 1Symptoms of babesiosisSymptomPercentage of outpatients (n ¼41)Percentage of inpatients (n ¼173)Percentage of total (N ¼214)Fever688985Fatigue787979Chills396863Sweats415653Headache753239Myalgia373233Anorexia252424Cough172322Arthralgia311718Nausea 22916Outpatient cases are from Ruebush and colleagues [51]and Krause and colleagues [16].Inpatient cases are from White and colleagues [50]and Hatcher and colleagues [48].474VANNIER et ala week to several months.Many people who are infected with B microti may never experience symptoms,as indicated by the disparity between the sero-prevalence and number of indigenous reported cases [49].A survey of adults living on Shelter Island,New York,showed that 6of 102(5.9%)had B mi-croti indirect immunofluorescence assay (IFA)antibody at titers of 1:64or greater [66].Similar disparities were noted in serosurveys in Connecticut,Massachusetts,and Taiwan [24,49,67].An estimate of the actual rate of asymptomatic babesial infection was derived from an epidemiologic study of babesiosis performed on Block Island,Rhode Island [44].Symptomatic babesial cases were identified by physicians at the Block Island Medical Center.Asymptomatic babesial infections were identified among healthy residents participating in an annual serosurvey who reported no babesial-like illness but seroconverted against B microti antigen during the previous year.Overall,about one third of babesial infections on Block Island were asymptomatic,including 19%(13of 67)of adults and 40%(4of 10)of chil-dren [44].Asymptomatic infection also may occur for months or years fol-lowing resolution of symptomatic babesial disease [56].It is uncertain whether patients experiencing asymptomatic babesial infection are at risk for any complications,although they may transmit the infection if they do-nate blood [21].PathogenesisTwo major processes underlie the pathogenesis of babesiosis d red blood cell modification by the pathogen and the host immune response to the pathogen.Red blood cell modificationThe only cells infected by Babesia sp are erythrocytes.A study of B bovis infection revealed that variable merozoite surface antigens (VMSA)mediate the attachment of free merozoites and sporozoites to red blood cells [68].Table 2Complications of babesiosis in 34consecutive hospitalized patientsComplicationFrequency (%)Acute respiratory failure21Disseminated intravascular coagulation18Congestive heart failure12Coma/lethargy9Renal failure6Death 9The mean age of patients was 53years,the median age 43years,and the range 3months to 85years.Data from Hatcher JC,Greenberg PD,Antique J,et al.Severe babesiosis in Long Island:review of 34cases and their complications.Clin Infect Dis 2001;32(8):1117–25.475HUMAN BABESIOSIS476VANNIER et alHeparin sulfate–like glycosaminoglycans and sialoglycoproteins on the sur-face of red blood cells also are engaged[68,69].After reorientation of the merozoite,proteins are secreted from rhoptries and micronemes that medi-ate parasite entry into the erythrocyte[70].The parasite reproduces by binaryfission,generating as many as four merozoites.The egress of mero-zoites eventually leads to the loss of red blood cell membrane integrity. As the infection progresses,hemolytic anemia develops and may be accom-panied by tissue hypoxia.As with Plasmodium sp,Babesia sp export proteins that are incorporated into the red blood cell membrane.Like the Plasmodium falciparum erythro-cyte membrane protein1(PfEMP1),the variant erythrocyte antigen 1(VESA1)of Babesia bovis appears to be encoded by a highly polymorphic gene[70].Such polymorphisms are thought be beneficial to the parasite,be-cause the expression of different variants over the course of infection allows the parasite to escape the immune response mounted by the host[71,72]. VESA1appears to promote cytoadherence of infected red blood cells to the vascular endothelium,although the evidence is less compelling than for PfEMP1[73].Cytoadherence is thought to facilitate persistent infection, perhaps by diminishing access of host immune cells to infected erythrocytes or preventing removal of infected erythrocytes by the spleen[74].In B bovis and B duncani infections,excessive cytoadherence and sequestration lead to microvascular obstruction and tissue hypoxia[75–77].Erythrocyte cytoad-herence and sequestration are yet to be documented in B microti or B diver-gens infections[78,79].Host immune responseThe host immune response is required to control and clear Babesia-in-fected red blood cells but also may cause pathology.Cytokines are central to both aspects of the immune response.Sequential cytokine gene expres-sion is thought to confer protective immunity,with expression of the inflam-matory cytokines interleukin-12(IL-12)and interferon-g(IFN-g)preceding expression of the anti-inflammatory cytokines IL-4and IL-10[80,81].In mice infected with B duncani,IFN-g is required for survival[82].In mice in-fected with B microti,a lack of IFN-g increases peak parasitemia and pro-longs or prevents resolution of parasitemia[83,84].CD4þT lymphocytes are the main source of IFN-g in B microti infection[84]but do not appear to contribute to resistance in B duncani infection[82].In contrast,NK cells are the main source of IFN-g in B duncani infection[82]but are not required for resistance in B microti infection[85].IFN-g,in synergy with inflamma-tory cytokines such as tumor necrosis factor-a(TNF-a),activates macro-phages to produce nitric oxide that kills intracellular parasites[82,86,87]. Merozoites themselves also can induce inflammatory cytokines and nitric oxide[87,88].Thefine-tuning of IFN-g and TNF-a by the anti-inflammatory cytokines IL-4and IL-10[89]may ensure that the inflammatory reactionremains mainly localized to the spleen.As a stronger inflammatory reaction is required to contain and resolve a more severe infection,the inflammatory re-action may spill into the systemic compartment,thereby generating a sepsis-like syndrome or evoking the adult respiratory distress syndrome.Pulmonary inflammation is the most common complication in persons ex-periencing severe B microti infection with as many as a fifth of severely ill patients suffering from noncardiac pulmonary edema [48].Edema and in-flammation also have been noted in the lungs of B duncani infected mice[90].IFN-g is detected around and within the pulmonary vessels,whereas TNF-a is mostly localized to the alveolar septa [90].In this model,infection with B duncani is fatal and blockade of TNF-a prevents death.Excessive cy-tokine production is thought to be a major cause of severe babesial disease and is associated with tissue pathology that can lead to significant end-organ damage [91,92].Immunosuppressed patients experiencing babesiosis generally suffer se-vere disease.The nature of the immunosuppression provides useful insights regarding the immune cells critical for host resistance.Patients with immu-nosuppressive conditions that primarily affect the CD4þT lymphocyte com-partment,such as HIV/AIDS,may develop fulminant and persistent B microti infection [56,58–60].Elderly individuals who are known to experi-ence a progressive contraction of the naıve CD4þT compartment are pre-disposed to severe,sometimes fatal B microti infection [48,50].The importance of T lymphocytes,particularly CD4þT cells,has been con-firmed in mouse models of B microti infection [84,93–95].On the other hand,virtually every person who resolves their babesial infection develops specific antibabesial antibody,implying that antibodies help clear infected red blood cells.In addition,patients who have lymphoproliferative disor-ders of the B-cell compartment and who are treated with regimens that de-plete B cells also are at risk for persistent or relapsing babesiosis [56],suggesting an important role for B cells in host resistance.Nevertheless,studies of B microti infection in mice do not provide strong evidence of a role for B cells and immunoglobulins in host resistance [83,96–98],imply-ing that additional immune dysfunction is required for symptomatic babesi-osis to develop in patients with B-cell proliferative disorders.DiagnosisClinical diagnosisThe diagnosis of babesiosis requires strong clinical suspicion because the symptoms of babesial infection may overlap with those of several other ill-nesses.There are no pathognomonic signs on physical examination.Babesi-osis should be considered when individuals present with viral-like symptoms and have recently spent time outdoors in a babesial endemic area during the summer or early autumn months.With changes in climate patterns,the 477HUMAN BABESIOSISduration of the babesiosis season and the location where babesiosis cases might be found may extend [99].Babesiosis also should be considered in peo-ple experiencing Lyme disease or human granulocytic anaplasmosis,because any combination of the three infections can be transmitted simultaneously by I scapularis [46].Laboratory diagnosisBabesial infection causes lysis of erythrocytes that usually results in a nor-mocytic hemolytic anemia,decreased serum haptoglobin,and hyperbilirubi-nemia with an elevated indirect bilirubin fraction.Elevated concentrations of serum lactate dehydrogenase,transaminases,and alkaline phosphatase also may occur [50].An elevated reticulocyte count and thrombocytopenia are commonly observed [46].Leukocyte counts are generally normal to slightly decreased with a left shift.Proteinuria and elevated blood urea ni-trogen and creatinine also may occur in severe cases.Urinalysis may likewise reflect hemolysis with hemoglobinuria.Definitive diagnosis of babesial infection generally is made by micro-scopic identification of the organism (Fig.2)on Giemsa or Wright stains of thick and thin blood smears [100].Babesia sp may appear as round,oval,or pear-shaped forms,with blue cytoplasm and red chromatin.Multi-ple parasites may be present in a single infected red blood cell.The ring form is most common and is similar to that of Plasmodium falciparum .Distin-guishing features of babesiosis on smear include the presence of extraery-throcytic forms in severe cases and the absence of pigment deposits (hemozoin)typically seen in older ring stages of P falciparum .Tetrads of merozoites arranged in a Maltese cross pattern are pathognomonic of bab-esiosis but rarely are seen [100].The percent of infected erythrocytes varies over the course of infection.Often,less than 1%of erythrocytes are parasit-ized early in the course of illness;therefore,multiple blood smears may need to be examined over several days to identify parasiteforms.Fig.2.Ring forms of Babesia microti in human blood smear (Â1000).478VANNIER et alIf the suspicion of babesiosis remains high despite negative smears,babe-sial DNA may be amplified from blood samples using the polymerase chain reaction(PCR)[101,102].PCR provides a highly sensitive and specific,al-beit,expensive test for detecting babesial DNA in blood.Babesial DNA may be amplified for months after initial infection despite standard treat-ment and resolution of clinical illness[57].Rigorous precautions are re-quired to avoid false-positive PCR results.Serology also is useful in confirming a babesial diagnosis.Antibabesial IgM and IgG antibodies can be detected by IFA[103–105].A babesial IFA titer of1:1024or greater usu-ally signifies active or recent infection[105].Titers generally return to1:64or less within8to12months but may persist for years[57,105].In rare circum-stances when the conventional tests are negative but babesiosis is still sus-pected,the diagnosis may be made by injecting of patient blood into hamsters;an intense parasitemia will develop2to4weeks after inoculation of this highly susceptible host[106].TreatmentPatients who experience symptomatic babesiosis should be given a course of antimicrobial therapy upon confirmation of the diagnosis by blood smear or PCR[53,107,108].Two commonly used antimicrobial regimens are highly effective d the combination of atovaquone and azithromycin and the combi-nation of clindamycin and quinine(Table3).Mild-to-moderate illnessAtovaquone and azithromycin administered for7to10days is the reg-imen of choice for mild-to-moderate babesiosis.Alternatively,clindamycin and quinine may be given;however,adverse affects associated with this combination occur at a relatively high frequency.In particular,tinnitus and gastroenteritis limit the ability of many patients to tolerate this regi-men.The two regimens were directly compared in adults in a prospective, nonblinded,randomized control trial[107].Although these drug combina-tions were similarly effective in clearing parasitemia and achieving resolu-tion of symptoms,adverse effects were reported in15%of subjects who received atovaquone and azithromycin compared with72%of subjects who received clindamycin and quinine.Furthermore,about one third of subjects taking clindamycin and quinine experienced adverse reactions that were severe enough to require a decrease in dosage or discontinuing the medication.In contrast,only2%of subjects taking atovaquone and azithromycin experienced such severe drug reactions.Although the atova-quone and azithromycin combination has not been studied in a controlled trial for pediatric use,cure has been achieved with use of this regimen in children[20,109].Severe diseaseIn patients with severe disease,the combination of clindamycin (admin-istered intravenously)and quinine given for 7to 10days is the treatment of choice (see Table 3)[53,108].The combination of pentamidine and tri-methoprim-sulfamethoxazole was used successfully to treat a case of B di-vergens infection [110].B divergens infections are consistently described as life threatening,and clindamycin and quinine should be used for all such cases,in addition to exchange blood transfusion [65].Exchange red blood cell transfusion is indicated for all babesiosis patients experiencing heavy parasitemia (R 10%)or who have significant pulmonary,renal,or hepatic compromise [48,111–113].Partial or complete exchange transfusion rapidly decreases parasite burden and removes toxic byproducts of babesial infection.Despite standard combination antimicrobial therapy,persistent relapsing babesial infection may develop in patients with significant underlying immu-nosuppression [56,114].Atovaquone-proguanil (250mg and 50mg)was used to eradicate parasitemia in one such patient [114].In a recent case-con-trol study of chronic babesiosis in 14highly immunocompromised patients,Table 3Treatment of babesiosisAntimicrobial agentsDose Frequency Atovaquone and azithromycinAtovaquone Adult:750mg Every 12hoursChild:20mg/kg (maximum 750mg/dose)Every 12hoursAzithromycin Adult:500to 1000mg On day 1250to 1000mg On subsequent daysChild:10mg/kg (maximum 500mg/dose)On day 15mg/kg (maximum 250mg/dose)On subsequent daysClindamycin and quinine Clindamycin Adult:600mg Every 8hoursChild:7–10mg/kg(maximum 600mg/dose)Every 6–8hours Intravenous administrationAdult:300–600mgEvery 6hours Child:7–10mg/kg(maximum 600mg/dose)Every 6–8hours QuinineAdult:650mgEvery 6–8hours Child:8mg/kg (maximum650mg/dose)Every 8hours Exchange transfusionExchange transfusion or partial exchange transfusion should be considered for treatment of severe cases of babesiosis.All antibiotics are administered by mouth unless otherwise specified.All doses administered for 7to 10days except for persistent relapsing infection (see text).。
奥马珠单抗辅助治疗难治性过敏性哮喘伴鼻炎患儿的效果
- 10 -[16]杨莹,赵谦,张淑悦,等.i-PRF 复合Bio-Oss 骨粉在拔牙位点保存中的应用研究[J].临床口腔医学杂志,2021,37(4):205-210.[17]郑少平.拔牙位点保存技术对前牙口腔种植患者牙槽骨骨量及牙槽美学效果的影响[J].当代医学,2020,26(3):173-174.[18]承峥,孙秋望月,葛昕,等.前牙拔牙位点保存术后牙槽嵴软硬组织变化的临床研究[J].口腔医学,2019,39(1):20-24.[19]刘宇,姜华茂,王海鑫.微创拔牙联合位点保存技术在口腔后牙种植修复中的应用效果[J].山东医药,2020,60(28):84-87.[20]马临生,解军军.研究拔牙位点保存技术应用于种植牙的效果[J/OL].临床医药文献电子杂志,2020,7(38):17-18.https:///kcms2/article/abstract?v=sSXGFc3NEDK9RIJH0zn7H882MZSKwVd2s8fkpGjY8L2yOW8u5FDiObsJ2NW WU3_OJ5_7vXdioJ5tj-lzDh4nONmo-ifterZxGnVwVZApsYfp4tQ sT3qLpn45Jc971XGz2i-Rc70L2MOi65MRvycxmA==&uniplatfor m=NZKPT&language=CHS.(收稿日期:2023-05-12) (本文编辑:何玉勤)*基金项目:保定市科技计划项目(2041ZF135)①首都医科大学附属北京儿童医院保定医院耳鼻喉科 河北 保定 071000②首都医科大学附属北京儿童医院保定医院口腔科 河北 保定 071000通信作者:高士培奥马珠单抗辅助治疗难治性过敏性哮喘伴鼻炎患儿的效果*李慧① 聂雷① 张佩瑶① 刘煜① 高士培②【摘要】 目的:探讨奥马珠单抗辅助治疗难治性过敏性哮喘伴鼻炎患儿的效果。
方法:选取首都医科大学附属北京儿童医院保定医院2021年6月—2022年6月收治的96例难治性过敏性哮喘伴鼻炎患儿作为研究对象,按照治疗方案分为对照组(予以沙美特罗替卡松+布地奈德+丙酸氟替卡松+孟鲁司特钠+地氯雷他定治疗)48例和观察组(予以奥马珠单抗辅助治疗)48例。
A large X-ray flare from the Herbig Ae star V892 Tau
a rX iv:a st r o -p h /0310355v 1 14 O c t 2003Send offprint requests to :G.Giardino,ggiardin@rssd.esa.intpossess either a strong stellar wind nor a corona (as no magnetic dynamo mechanism is available).In contrast Herbig Ae/Be stars appear to possess a strong stellar wind (Skinner et al.1993;Bouret et al.1997)and a magnetic dynamo associated with an outer convection zone has been invoked to explain the periodic variation of the emission lines (Praderie et al.1986)as well as the stellar wind itself (Finkenzeller &Mundt 1984).Zinnecker &Preibisch (1994)proposed that the ob-served X-ray luminosity is linked to the stars’strong stel-lar winds,possibly originating in shocks due to wind insta-bilities and/or in the collision between the fast wind and the remnant circumstellar material.Damiani et al.(1994)also favored a stellar wind origin for the X-ray emission from Herbig Be stars.Nevertheless a magnetically heated corona could also be at the origin of the observed X-ray emission (Zinnecker &Preibisch 1994).The presence of winds and the possibility of magnetic activity make these objects interesting targets for X-ray studies.The unambiguous detection of flaring activity in any Herbig Ae/Be star would be significant as it would provide indirect but strong evidence for the presence of a magnetically confined corona and thus of an operational dynamo mechanism.So far there is only one reported observation of flar-ing activity in an Herbig Be star:Hamaguchi et al.(2000)performed ASCA observations of the Herbig Be starMCW297,and reported the detection of a largeflare during which the X-ray luminosity of the source increasedby a factor of5,with the plasma temperature increas-ing from2.7keV during the quiescent phase to6.7keV atflare maximum.The interpretation however is affectedby some ambiguity due to the large ASCA point spreadfunction(PSF).Testi et al.(1998)found about20infrared sources in the ASCA error circle around MWC297,themajority of which are likely to be low-mass protostars.The peak X-ray luminosity of≃5×1032erg s−1reported byHamaguchi et al.(2000)would correspond to a very large–but still possible–flare for a typical low-mass active T Tauri.For example Tsuboi et al.(1998)have reportedASCA observations of a largeflare from the Weak-linedT Tauri star(WTTS)V773Tau,in which the peakflare luminosity was at least∼1033erg s−1.The MWC297event therefore would not be exceptional for a low mass pre-main-sequence star.Hamaguchi et al.(2002b)have re-cently re-observed MWC297with Chandra,finding thesource hundred times less luminous in X-rays than esti-mated from ASCA observation,and with no evidence forvariability,thus casting some doubts on the original inter-pretation.In this article we report the observation of a large X-rayflare from the Herbig Ae star V892Tau.We have used publicly available XMM-Newton and Chandra datato monitor the X-ray activity of V892Tau and during one of the two XMM-Newton exposures a largeflare isobserved.While the apparent companion of V892Tau,V892Tau NE,is unresolved by the XMM-Newton PSF, as discussed later,the evidence that the observedflare iscoming from the Herbig Ae star is compelling.The present paper is organized as follow:after a briefintroduction of the properties of V892Tau below,the ob-servations are described in Sect.2.The spectral and tim-ing analysis of the data are presented in Sect.3and theresults are discussed in Sec.4.1.1.The Herbig Ae star V892TauV892Tau–also known as Elias1–is a young stellar ob-ject located in the Taurus dark cloud complex,and is sup-posed to be the source of the illumination for the faint neb-ula IC359.The apparent magnitude of V892Tau is R=13.14(Strom&Strom1994)and its spectral classification varies from B9(Strom&Strom1994)and A0(Elias1978;Finkenzeller&Mundt1984)to A6(Cohen&Kuhi1979, Berrilli et al.1992,The et al.1994).Estimates for the vi-sual extinction also vary from A V∼8(Elias1978)and A V=8.85(Strom&Strom1994,derived from a simul-taneous estimate of the spectral type and of the apparentcolor,R−I=1.71)to A V∼3.9(Zinnecker&Preibisch 1994).The star is usually placed at a distance of140pc because of its association with the Taurus dark clouds (Elias1978).The bolometric luminosity of V892Tau is L∼38L⊙(Berrilli et al.1992)and the source is variable in the near-infrared(Elias1978).Through near-infrared speckle interferometry Kataza&Maihara(1991)resolved V892Tau into an unresolved core and a sub-arcsec structure elongated in the east-west direction.They interpret the light of the elongated structure as being reflected within an edge-on circumstellar disk of moderate optical depth.Newer near-infrared speckle interferometry observations were performed by Haas et al.(1997),who favor a scenario in which the diffuse component is due to scattering in bipolar lobes with a polar axis oriented east-west.V892Tau appears to be a binary system(Leinert et al. 1997).The apparent stellar companion,hereafter referred to as V892Tau NE,lies4.1arcsec to the northeast,at po-sition angle22◦1(Skinner et al.1993).The available mea-surements allow a tentative classification of V892Tau NE as a WTTS with spectral type M2reddened by8–12mag of visual extinction(Leinert et al.1997).The study by Leinert et al.(1997),based on speckle interferometry,was carried out with the explicit purpose of detecting binaries among Herbig Ae/Be stars.Leinert et al.(1997)achieved a resolution of∼0.1arcsec,that at a distance of140pc correspond to14AU,and they do not detect other stars in the vicinity of V892Tau.They conclude that in the near-infrared V892Tau is basically a wide binary system.2.ObservationsThe X-ray observations discussed in this paper were ob-tained with the XMM-Newton and the Chandra obser-vatories.The XMM-Newton observations of V892Tau consists of two deep(74.4and45.1ks nominal)consec-utive exposures,thefirst starting on March112001at 12:40:22UT and the second one starting on March12 2001at10:23:10UT.All three EPIC cameras were active at the time of the observations,in full-frame mode with the mediumfilters.The Principal Investigator for these observations is F.Walter and the observation target is the triple WTTS system V410Tau.The observations are publicly available from the XMM-Newton archive.The raw XMM-Newton data have been processed by us with the standard SAS V5.4.1pipeline system,concentrat-ing,for the spectral and timing analysis,on the EPIC-pn camera.In each of the two XMM-Newton exposures the background is affected by a large protonflares of more than10ks of duration.We have retained only time inter-vals in which the count rate for the whole frame of pho-tons above5keV was below a certain threshold(3.3cts/s in the present case).This operation omits roughly30%of the observing time,but effectively reduces the background level by a factor of≃4.Source and background photons were extracted using a set of scripts purposely developed at PalermoObservatory.Source and background regions were defined interac-tively in the ds9display software,with the background extracted from regions on the same CCD chip and at the same off-axis angle as for the source region.Response matrices(“rmf and arffiles”)appropriate for the posi-tion and size of the source extraction regions were com-puted.The spectral analysis has been performed using the XSPEC package,after rebinning the source spectra to a minimum of20source counts per(variable width)spectral bin.The Chandra ACIS observation of V892Tau was taken starting on March72002at6:15:28UT(18.0ks nomi-nal).The Principal Investigator for these observations is P.Predehl and also in this case the observation target is V410Tau2.The data were retrieved from the public data archive,with no re-processing done on the archival data. Source and background regions were defined in ds9,and light curves and spectra were extracted from the cleaned photon list using CIAO V.2.2.1threads,which were also used for the generation of the relative response matrices. Spectral analysis was performed in xspec in the same way as for the XMM-Newton spectra.Fig.1shows the images of the V892Tau system in the Chandra ACIS camera and XMM-Newton EPIC-pn cam-era(before and after the largeflare)as well as the Palomar Digital Sky Survey image of thefield.The4images are on the same sky coordinate scale.The source at the cen-tre of the images is the V892Tau system.V892Tau and V892Tau NE are clearly resolved in the Chandra observa-tions.The XMM-Newton point spread function has a full width at half maximum of15arcsec and therefore cannot resolve the system.The source at38arcsec to the SE of the V892Tau system is[BHS98]MHO11,a T Tauri star (Brice˜n o et al.1998),first identified in ROSAT data by Strom&Strom(1994).The bright source in the North-East corner is Hubble4,a well known T Tauri.In Table1we report the coordinates of V892Tau and V892Tau NE as derived from the radio(VLA)observation of Skinner et al.(1993),to be compared with the coordi-nates of the sources in the XMM-Newton and Chandra data.The source coordinates from the EPIC-pn data cor-respond to the peak of a gaussian distributionfitted to the source image,the source coordinates for the Chandra data simply correspond to the brightest pixel in the source im-age.The agreement between the sources’positions in the Chandra image and as determined from VLA observations is excellent(within0.4arcsec).The source coordinates derived from the XMM-Newton observations before the flare have a2.4arcsec offset from V892Tau(well within the uncertainty expected for the determination of posi-tions of EPIC X-ray sources)and a6arcsec offset from V892Tau NE.After theflare the position offsets become4:18:4038364244464828:20:003019:0018:304:18:4038364244464828:20:003019:004:18:4038364244464828:20:003018:304:18:4038364244464828:20:003019:0018:30Fig.1.The field centered on the system V892Tau and V892Tau NE in the EPIC-pn camera before the flare (top left)and during the flare (top right),in the ACIS camera (bottom left)and in the Digital Sky Survey (bottom right).The images are on the same coordinate scale.The system is resolved in the Chandra data.The source at the south-east of the V892Tau system is [BH98]MHO 11,a T Tauri star,the source at North-East is Hubble 4,also a T Tauri.Table 1.Positions for the two components of the V892Tau system from radio (VLA)observations (Skinner et al.1993)and as derived here from XMM-Newton and Chandra images.SourceVLAXMM aXMM bChandraV892Tau 41840.6041840.6741840.6741840.63281915.9281913.7281912.9281915.8V892Tau NE41840.70c c 41840.74281919.7cc281919.3aX-ray quiescent,b X-ray flaring,c unresolved from V892Tau.3.2.XMM-Newton observationsThe light curve of the V892Tau system derived from the two consecutive XMM-Newton exposures are shown in Fig.4.All the gaps in the light curve except the one around 64ks are due to the filtering process that we have applied to the raw data in order to remove the effect of solar proton flares.In particular roughly 10ks at the be-ginning of the first exposure have been removed.The gap around 64ks is due to the time difference between the end of the first exposure and the start of the second (one hour).During the first ∼80ks the light curve of the V892Tau-V892Tau NE system presents significant vari-ability with a time scale and amplitude similar to the one observed for V892Tau in the Chandra data.During the last 30ks the light curve of the system undergoes a dra-matic variation,in what appears to be a large flare.The source counts increases by a factor of ∼8in less than 10ks.The source flux then remains at around the maximum level until the end of the XMM-Newton exposure.We have performed the spectral analysis of the two XMM-Newton exposures separately and we summarise the results into two separate tables:Table 2for the first ex-Fig.2.Background-corrected light curves of V892Tau (top)and V892Tau NE(bottom)from the Chandra data, where the two stars are well resolved.Note the different vertical scale.posure and Table3for the second exposure.The reasonfor this is that while for thefirst exposure two tempera-ture plasma models are necessary to obtain acceptablefits to the spectra for the second exposure one-temperatureplasma models provide adequatefits to the spectral data.The spectrum of the V892Tau system during thefirstexposure of74ks,corresponding to an effective integra-tion time of<∼64ks(after the protonflarefiltering pro-cess),is shown in Fig.5,together with the bestfit ab-sorbed2temperature plasma model.The bestfit valuesfor the model parameters are summarised in Table2to-gether with the reducedχ2of thefit and its null hypothesis probability,P.A model with an absorbing column density of N(H)=0.92×1022cm−2,plasma temperatures kT1= 1.02keV and kT2=2.82keV and a metal abundance Z=0.21provides a goodfit to the integrated spectrum. An absorbed one temperature plasma model(as used for the Chandra data,which however have lower statistics) does not provide an acceptable description of the spec-trum.Nevertheless a two temperature plasma model with a metal abundance and two plasma temperatures frozen Fig.3.Background-corrected spectra of V892Tau(top) and V892Tau NE(bottom),from the Chandra data.The best-fit absorbed1-T models are also shown.at the values above(Z=0.21,kT1=1.02keV and kT2= 2.82)provides a goodfit to the Chandra data(P=0.72) by letting the two emission measures and the absorbing column density vary–see Table2.Thefitted values for the two emission measures are EM1=(4.3±1.6)×1053cm−3 and EM2=(2.2±0.4)×1053cm−3,consistent with the values derived from the XMM-Newton spectrum.The rel-ative modelflux level is7.3×10−13erg cm−2s−1(in the 0.55–7.50keV band).The value for the absorbing col-umn density derived in this way from the Chandra data, N(H)=(1.24±0.09)×1022cm−2is higher than the value derived from XMM-Newton(and a model with the value derived from XMM-Newton does not provide an ac-ceptable description of the data).We note though that a systematically higher value for the absorbing column density derived from Chandra data is consistent with the known presence of(likely carbon-based)contamination on the ACIS chips.This causes additional low-energy absorp-tion(up to50%near the C edge)not accounted for in the current response matrices(Plucinsky et al.2003).Given the source variability during these∼64ks of observation,we have investigated the presence of signifi-cant spectral variation.We have subdivided the data into three intervals(thefirst30ks,the following18ks and thefinal16ks),chosen to ensure similar statistics in the resulting spectra.As the initial part of the observation israther heavily contaminated by high background,a higher fraction of it was discarded,and therefore thefirst inter-val is significantly longer.The three spectra were modeled with an absorbed two temperature plasma model.The fitted values of the model parameters are summarised in Table2.As it can be seen by inspecting the table,the short term variability observed in the system V892Tau during thisfirst XMM-Newton observation does not appear to be associated with significant spectral changes.A time resolved spectral analysis was also performed for the second XMM-Newton observation of V892Tau sys-tem,when the largeflare took place.The data were sub-divided into three intervals:afirst14ks interval while the source is quiescent,a second8ks interval while the source counts are rising and the last10ks,while the source is at its luminosity maximum3.The three spec-tra are shown in Fig.6,and their best-fit parameters are listed in Table3.As explained at the beginning of this section an absorbed one-temperature plasma model pro-vides an acceptable description for all the three spectra derived from this exposure,so we did not attemptedfits with two-temperature plasma models(which were neces-sary to obtain acceptablefits of the spectra derived from thefirst XMM-Newton exposure).In addition,the ap-proach toflare modelling that we present in Sect.4.2.1 relies on single temperature paramaterization of the X-ray spectrum.Nevertheless,for the spectrum derived from the first14ks interval of this exposure(corresponding to the quiescent phase),we verified that an absorbed two tem-perature plasma model with a metal abundance and two plasma temperatures frozen at the values derived from the first XMM-Newton exposure(Z=0.21,kT1=1.02keV and kT2=2.82)indeedfits the spectrum(P=0.08).The value for the absorbing column density derived in this way is N(H)=(0.83±0.08)×1022cm−2,somewhat higher than the value derived with the one-temperature plasma fit(N(H)=(0.65±0.06)×1022cm−2,second line of Table3),and in better agreement with the value derived from thefirst XMM-Newton exposure.This confirms the lack of significant spectral variation in the V892Tau sys-tem during the quiescent phase.As can be seen from Table3,during theflare the only significant spectral variation occurs in the plasma temper-ature,while thefitted values for absorbing column density and plasma metallicity remain essentially unchanged.The plasma temperature increases from kT=1.53keV before theflare to kT=8.11during the rising phase and remains around that value afterwards.The model dependentflux density of the source,in the energy band0.35–7.50keV, goes from6.7×10−13erg cm−2s−1before theflare to 1.0×10−11erg cm−2s−1during theflare maximum.The peak X-ray luminosity for theflare is L X=2.4×1031erg s−1,high but not exceptionally so for stellar X-rayflares.Table2.Thefirst four lines of the table report the best-fit spectral parameters for the V892Tau system during the first XMM-Newton observation(before theflare).The parameters are derived assuming a two-temperature optically thin plasma model.Fits with a single temperature absorbed plasma model are unacceptable in this case.The last line reports the result of a spectralfit to the Chandra data on V892Tau with a two-temperature plasma model with the two plasma temperatures and the metal abundance frozen at the values derived from this XMM-Newton exposure (first line).See text.Time interval N(H)kT1kT2EM1EM2Zχ2P0–64(total)0.92±0.051.02±0.042.82±0.415.62±2.613.56±1.210.21±0.06 1.070.21 0–300.94±0.100.98±0.10 2.69±0.32 2.65±2.16 4.46±1.090.51±0.200.920.6630–480.89±0.07 1.08±0.09 3.17±1.267.42±4.98 3.03±3.080.13±0.09 1.140.1548–640.98±0.130.77±0.08 1.95±0.17 3.79±2.84 4.43±1.110.31±0.15 1.170.16∗Chandra data(total exposure time)Table3.Best-fit spectral parameters for V892Tau and V892Tau NE during the Chandra observation and the second XMM-Newton exposure.The spectral parameters are derived assuming a single-temperature optically thin plasma model.Source N(H)kT EM Zχ2PV892Tau(Chandra)0.83±0.08 2.10±0.19 4.31±0.950.06±0.07 1.040.40V892Tau(XMM1)0.65±0.06 1.53±0.16 5.19±1.490.09±0.05 1.330.06V892Tau(XMM2)0.97±0.058.11±1.0021.22±1.010.16±0.090.900.79V892Tau(XMM3) 1.00±0.04 6.68±0.5826.44±1.110.26±0.08 1.010.46XMM1:X-ray quiescent,XMM2:rising phase of largeflare,XMM3:flare maximumAs already mentioned,V892Tau and V892Tau NE areunresolved by the XMM-Newton PSF,nevertheless the ev-idence that the origin of the observedflare is the HerbigAe star is compelling.First,as summarised in Table1,theXMM-Newton position,before and during theflare,of thesource associated with system the V892Tau is between2.4and3.1arcsec from the radio position of the main starV892Tau,while is between6and6.8arcsec offthe posi-tion of V892Tau NE.The absolute measurement accuracyof the XMM-Newton pointing is4arcsec(XMM-NewtonUsers’Handbook),so the offset of the source in the EPIC-pn image from the radio coordinates of V892Tau is wellwithin1σof the pointing accuracy.This is fully consistentwith V892Tau being the dominant source of X-ray emis-sion throughout the XMM-Newton observation,as it is thecase during the Chandra observation,where V892Tau isroughly10times more luminous than V892Tau NE.Second,the XMM-Newton position of the source asso-ciated with the system V892Tau before and during theflare is constant within0.7arcsec4,while the angular sep-aration of V892Tau and V892Tau NE is4.1arcsec.Atthe same time(as shown in the previous section)the spec-Fig.6.Background-corrected spectra of the V892Tau system during the tree different phases of the second XMM-Newton observation.From top to bottom:14ks integration time before theflare,8ks during the rising phase of theflare,10ks during theflare maximum.4.1.Quiescent emissionBy“quiescent”here we mean the time when V892Tau is not undergoing the largeflare,even though during this phase we do observe smallerflare-like events(both in Chandra and XMM-Newton data).The Chandra spectrum and the XMM-Newton spectra of V892Tau while the source is quiescent can all be well described by an absorbed two temperature plasma model with N(H)∼0.9×1022cm−2kT1=1.0keV,kT2=2.8keV and a relative metal abundance of Z=0.2Z⊙. As discussed above,for the Chandra data a slightly higher value of N(H)is required in order tofit the spectrum,con-sistent with the known contamination of the ACIS chips. Here therefore we only refer to the value for N(H)derived from the XMM-Newton data.The X-ray emission from V892Tau has been studied previously by Strom&Strom(1994)and Zinnecker&Preibisch(1994).These two works use the same ROSAT observation but derive from it different model parameters.Strom&Strom(1994)fit the spectral data with an absorbed two temperature plasma model with N(H)≃1.3±0.6×1022cm−2,kT1=0.55,kT2=1.20 and estimate an X-ray luminosity L X=1.0×1031erg s−1 (in the0.2–2.4keV band).Zinnecker&Preibisch(1994) model the spectra of V892Tau with an absorbed1temper-ature plasma with N(H)=(4.8±1.1)×1021cm−2,kT=2.3±0.4keV and estimate L X=(1.9±0.8)×1030erg s−1(a factor of≃5lower than the estimate of Strom&Strom 1994).We derive N(H)∼0.9×1022cm−2,compatible to the estimate of Strom&Strom(1994).This value for the absorbing column density corresponds to a visual extinc-tion5of A V∼4.7,which is close to the value estimated by Zinnecker&Preibisch(1994)from the B−V value given in Herbig&Bell(1988)and a factor of∼2lower than derived by Elias(1978)and Strom&Strom(1994)6.We note that a lower value of visual extinction is consistent with the star spectral type being A6rather than B9.The two temperatures for the two component plasma model that we derive here are significantly higher than the values given by Strom&Strom(1994);this is not un-expected given the much softer(and narrower)bandpass of the ROSAT PSPC instrument used by Strom&Strom (1994).The temperature derived from our1plasma com-ponentfit to the Chandra data(kT=2.1keV)is how-ever consistent with plasma temperature estimated by Zinnecker&Preibisch(1994).The values we derived for the two plasma temperatures in V892Tau are somewhat higher than the typical values derived for the X-ray emis-sion from low mass PMS in Taurus:in an analysis of the spectral characteristic of9T Tauri stars in L1551we found typically kT1∼0.3and kT2∼1.2(Favata et al.2003). On the other hand the value for the plasma metallicity Z=0.2for V892Tau is typical of the value we derived in the same study for the4Weak Lined T Tauri stars in the sample.The intrinsic luminosity we estimate for V892Tau in its quiescent state is L X=1.6×1030erg s−1,in good agreement with the value given by Zinnecker&Preibisch(1994)and a factor of∼6lowerthan derived by Strom&Strom(1994).This indicate that Zinnecker&Preibisch(1994)are probably correct when they suggest that the reason for the discrepancy between their values and the one derived by Strom&Strom(1994) is the fact that Strom&Strom may have erroneously in-cluded the nearby source[BHS98]MHO11in the source circle of V892Tau.A wind-related origin of the X-ray emission has been proposed for Herbig Ae/Be stars by Zinnecker&Preibisch (1994)and Damiani et al.(1994).This scenario,however, seems an unlikely explanation for the origin of the X-ray emission on V892Tau in its quiescent phase.As described in Sect.3,during this phase,V892Tau presents significant short term variability,with its X-ray flux varying by a factor of2in less than1ks.The impulsive rise influx appears to be associated with an hardening of the spectrum in the Chandra data.This type of variabil-ity is similar to the one observed in lower-mass pre-main-sequence stars,where the X-ray emission is of coronal ori-gin,while being substantially different from the20–30% X-rayflux variations observed in OB stars(Collura et al. 1989;Cassinelli et al.1994)where the emission mecha-nism is wind-related.In addition,from the luminosity of V892Tau esti-mated to be around38L⊙(Berrilli et al.1992),its ratio of X-ray luminosity to the total luminosity while quiescent is L X/L bol≃1×10−5.This is two orders of magnitudes greater than the typical ratios found for OB stars.On the other hand a value of L X/L bol≃10−5is not uncommon for low mass stars in which the X-ray emission mechanism is coronal.The possibility of a wind related origin of the X-ray emission from V892Tau in its quiescent phase appears therefore unlikely.This is in agreement with the conclu-sions reached in the two statistical studies of the properties of Herbig Ae/Be stars of Preibisch&Zinnecker(1996)and Hamaguchi et al.(2002a).These studies indicate that the X-ray emission from Herbig Ae/Be stars is generally asso-ciated with higher plasma temperature and higher X-ray to bolometric luminosity ratios than typically observed for the X-ray emission from main sequence OB stars.A wind scenario,finally,cannot account for the ob-servedflare event of V892Tau.4.2.Flare eventDuring theflare event the X-ray luminosity of V892Tau increases by a factor of∼15,from L X=1.6×1030erg s−1to L X=2.4×1031erg s−1,while the temperature of the plasma increases from kT=1.5keV to kT=8.1keV. The source luminosity increases over a relatively long time of≃10ks,and hovers close to the luminosity maximum for at least another10ks thereafter–the end of the ob-servation does not unfortunately allow to study the decay phase.As demonstrated by Reale et al.(2002)flares of this type cannot take place in the freely expanding plas-moids of a stellar wind.The observed slow increase of X-ray luminosity at the beginning of theflare event requires the presence of a confining magneticfield.In order to gain some quantitative insight on the event and given the similarities of the derived light curve with the ones of other stellarflares we have analyzed the event through scaling obtained from detailed hydrody-namic models offlaring plasma confined in a closed coronal loops,as in solarflares.4.2.1.Flaring region characteristicsIt is customary to derive information about the size of the flaring loops from theflare evolution,i.e.the light curve. It has been shown that the decay time of the light curve is linked to the plasma cooling times,which,in turn,depends on the length of the loop which confines the plasma(e.g. Reale2002and references therein):the slower the decay, the longer the loop,unless a significant residual heating sustains the decay and makes the decay-time/cooling-time dependence less tight.The XMM-Newton observation of theflare on V892 Tau does not cover the decay phase and therefore diag-nostics using the characteristics decay times are not feasi-ble.For this particularflare,however,we are able to infer some information on the size of theflaring region from the observed rise phase.The evolution of theflaring plasma confined in a loop is well-known from extensive hydrodynamic loop model-ing(e.g.Peres et al.1982):a strong heating pulse is trig-gered in an initially quiescent coronal loop and makes the temperature increase by up to several tens of MK along the whole loop in a few seconds,due to the high plasma thermal conduction.The dense chromosphere at the loop footpoints is heated violently and expands upwards with a strong evaporation front.The rising plasmafills up the loop,very dynamicallyfirst and then more gradually,ap-proaching a new hydrostatic equilibrium at a very high pressure.The loop X-ray emission increases mostly fol-lowing the increase of emission measure,and forms the rise phase of theflare.Although the evolution in the rise phase is very dy-namic and non-linear,we can nevertheless derive an ap-proximate time scaling.From the equation of energy con-servation of the confined plasma(e.g.Eq.(3)in Serio et al. 1991)it can be seen that,after the very initial seconds, dominated by the plasma kinetics,the evolution in the bulk of the rise phase can be approximately described as a linear increase of the plasma internal energy density driven by the(constant)energy input rate per unit volume:dǫ。
x-ray protection(presentation)
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Low grade affect:
Skin burns, Hair lost Transform water into toxic compound
High level affect:
Cancerization Blood diseases Destroy large molecules (genetic mutation, enzyme ionization)
Two properties X-ray hold to harm patients’ health: 1.Penetrativity: With a short wave length, X-ray can easily reach the inner part of a patient’s body, where organs work. 2.High energy: The huge amount of energy it carried is sufficient to ionize big molecules (protein, DNA and enzyme) which construct our cells or participate in important reactions. it is extremely easy for a cell to complete cancerization process after such huge damage.
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Environment effect: the side effect is small, when introduced low temperature and oxygen lack environment.
IN situ observations of the pest oxidation process of NbSi2 at 1023K
In situ observations of the pest oxidation process of NbSi 2at 1023KF.Zhang,L.T.Zhang *,A.D.Shan,J.S.WuKey Laboratory of the Ministry of Education for High Temperature Materials and Testing,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200030,People Õs Republic of ChinaReceived 21January 2005;received in revised form 24May 2005;accepted 27May 2005Available online 21June 2005AbstractOxidation processes of poly and single crystalline NbSi 2were observed in situ by high temperature optical microscopy to clarify the pest phenomenon.Pest disintegration is mainly determined by the pre-existing cracks in the microstructure.Porosity and grain boundary are the preferential oxidation sites.Pest oxidation of NbSi 2at 1023K is not an intrinsic material property.Ó2005Acta Materialia Inc.Published by Elsevier Ltd.All rights reserved.Keywords:In situ observation;Oxidation;NbSi 2;Microstructure;Pest phenomenon1.IntroductionAccelerated and pest oxidations at low temperature have been known for a long time in refractory transi-tion-metal disilicides such as NbSi 2[1–3]and MoSi 2[4–6],which are promising candidates for high tempera-ture applications.Disintegration of a specimen from bulk into powder happens after a certain period of expo-sure in air at a relatively low temperature,typically 1023K for NbSi 2and 773K for MoSi 2.Many factors such as composition,temperature,atmosphere and de-fects are found to be related to the pest oxidation based on many observations for NbSi 2and MoSi 2[7–9].How-ever,a direct description of pest mechanism is unavail-able and most of the attention has been paid to MoSi 2.Early works [10–12]suggested pest oxidation resulted from inter-granular oxidation and ter works [13]noticed the effects from structural defects and imperfections such as pores and cracks in the bulk mate-rial on the catastrophic fragmentation.Berztiss et al.[14]showed there was fragmentation near 773K in as-cast MoSi 2containing microcracks but not in denseMoSi 2and single crystal MoSi 2.Other works [7,8,15]also showed that accelerated oxidation and fragmenta-tion could be suppressed in fully dense and single crystal MoSi 2.However,Chou and Nieh [16]reported severe pest in monolithic poly and single crystalline MoSi 2.De-fects contained in the specimen such as pre-existing cracks,pores and grain boundaries are the preferential oxidation sites and therefore they should be associated with pest oxidation.Present observations on microstruc-ture conditions of the occurrence of pest phenomenon are thus somehow inconsistent with each other.There-fore,the individual role of these defects in the pest oxidation needs to be clarified.Similar work on NbSi 2is scarce at the moment.In this study,the focus has been placed on in situ observa-tions of the oxidation process of both poly and single crystalline NbSi 2using high temperature optical micro-scopy in order to clarify the pest oxidation process.2.Experimental proceduresStoichiometric polycrystalline NbSi 2was prepared by arc-melting from high purity raw elements under an argon atmosphere.Single crystals of NbSi 2were grown1359-6462/$-see front matter Ó2005Acta Materialia Inc.Published by Elsevier Ltd.All rights reserved.*Corresponding author.Tel.:+862162932566;fax:+862162932587.E-mail address:Lantingzh@ (L.T.Zhang).Scripta Materialia 53(2005)653–656by the optical heatingfloating zone method on Asgal FZ-20035WHV apparatus.Relative densities of the as-cast ingot and single crystals were determined to be 97.0%and99.3%of the theoretical value,respectively. Specimens approximately3·3·1mm in dimension were cut from the arc-melted ingots and as-grown single crystals(perpendicular to the growth direction).The specimens were polished to a mirrorfinish and cleaned in acetone and alcohol subsequently,prior to observation.The oxidation process was observed in situ under a high temperature optical microscope equipped with a thermal stage(Linkam TS1500)in air atmosphere.Dur-ing the observation,the thermal stage was heated to 1023K at a heating rate of80K/min and then kept at 1023K.The temperaturefluctuation during observation was within1K.For comparison,the oxide products of the poly and single crystalline specimens oxidized in a muffle furnace were characterized by X-ray diffraction.3.ResultsThe arc-melted polycrystalline NbSi2contains quite a number of pre-existing microcracks and pores in its microstructure,as typically shown in Fig.1(a).Grain boundaries are not clearly visible in the as-polished state.A series of micrographs were taken during the iso-thermal oxidation at1023K(Fig.1(b)–(f)).Shortly after heating to1023K,the grain boundaries were clearly seen and a difference in colors between different grains was revealed,implying preferential oxidation at the grain boundary and dependence of oxidation resis-tance on crystallographic orientation(Fig.1(b)).With extended exposure time,some dots were seen inside the grain(Fig.1(c)),which are probably due to porosity and impurities.More importantly,some cracks were found to initiate from the pre-existing cracking sites in the specimen,as shown in Fig.1(c).These cracks started to expand after initiation and propagated across the grain boundary during the oxidation process(Fig.1(d)).When the newly initiated crack met the pre-existing ones,the propaga-tion was stopped and the crack started to open apart with the increase in exposure time(Fig.1(e)and(f)). However,no cracks were found to initiate from the grain boundary or the pores in the microstructure.The color of the grain boundary became darker and itswidth Fig.1.Optical micrographs of arc-melted polycrystalline NbSi2oxidized at1023K for:(a)t=0min;(b)t=1min;(c)t=25min(d)t=70min; 654 F.Zhang et al./Scripta Materialia53(2005)653–656broadened as a result of the oxidation process(Fig. 1(e)).When exposed for220min,fragmentation hap-pened at the right portion of the specimen along a large crack consisting of pre-existing cracks and newly induced ones(Fig.1(f)).This is consistent with our pre-vious observation conducted in a muffle furnace that the arc-melted polycrystalline NbSi2disintegrated into pow-der after3h at1023K[17].Unlike the polycrystalline specimen,single crystal NbSi2is free of grain boundaries and cracks in the micro-structure.Although the specimen surface changed its color continuously at the initial stage,no crack initiation and extension was observed during the isothermal oxida-tion process.There was even no change at the occasional scratches and pores on the surface.This indicates that single crystal NbSi2will not fragment due to oxidation. Fig.2illustrates an observation at1023K on a piece of single crystal NbSi2with pre-introduced cracks by the indentation method.Many microcracks were introduced around the indentation(Fig.2(a)).During the isothermal oxidation process,these cracks were oxidized and new cracks initiated from them(Fig.2(b)).As time increased, cracks were found to be broad and additional new cracks initiated(Fig.2(c)).Obvious spallation of the surface around cracks could be found after354min(Fig.2(d)). Thus pre-existing cracks are proven to be the main rea-son for pest oxidation.4.DiscussionThe initiation and cracking processes that lead to pest oxidation in NbSi2at1023K has been demonstrated in our current in situ observation.A comparison among arc-melted polycrystalline,single crystalline NbSi2and single crystalline specimens with indentation induced microcracks clearly indicates that the pre-existing crack in the specimen is the main reason for pest oxidation. This is also supported by the fact that no pest oxidation can be found in dense polycrystalline and single crystal-line NbSi2[17]and MoSi2[3,7,8].According to the present observation,pest phenome-non can be ascribed to simultaneous crack initiation and propagation during the oxidation process leading to fragmentation,as depicted in Fig.3.Cracks instead of grain boundaries play an important role.The trans-granular propagation of cracks suggests a weak effect from the grain boundary.Powder X-ray diffraction shows that there is no qualitative difference in the oxide formed on the polycrystalline and single crystalline NbSi2at1023K(Fig.4).The oxide is composed of Nb2O5and SiO2(mostly amorphous),which is consis-tent with most research[3,16].The volume expansion due to oxidation is estimated to be as high as183%, therefore a large stress can be established at the crack tip.Since NbSi2is a brittle material whose fracture toughness is around2.3MPaffiffiffiffimp,cracks can easily be initiated and expand from a sharp tip available(Fig. 3(b)),which is known as the wedging effect[14].This is similar to what was proposed by Fizter[12]and Sch-lichting[11]for MoSi2.Compared to a crack,even though grain boundaries and pores are the preferential oxidation sites in the microstructure,neither of them offers a sharp tip and free surface where stress can accumulate when oxide is formed.This explains why no fragmentationwas Fig.2.Optical micrographs of single crystalline NbSi2with some pre-introduced cracks oxidized at1023K for:(a)t=0min;(b)t=82min;F.Zhang et al./Scripta Materialia53(2005)653–656655observed in the crack-free NbSi2.The pest oxidation in NbSi2is not an intrinsic material property.However,in situ observation shows that both pores and grain bound-ary are preferential oxidation sites in the microstructure. Therefore,pores and grain boundaries are attributable to quick oxidation kinetics.This has been noticed from the difference in the weight change as a function of time in single crystal NbSi2and spark plasma sintered speci-mens having different relative densities[17].The number of cracks contained in the specimen determines the time needed for fragmentation;thus,it takes a longer time for a specimen with fewer cracks to disintegrate into small pieces.5.ConclusionsBy using high temperature optical microscopy,the oxidation process of NbSi2at1023K has been revealed.1.Initiation and extension of cracks from the pre-exist-ing cracking sites are observed during isothermal oxidation.Pre-existing cracks in the specimen are the main reason for pest oxidation.2.Grain boundary and porosity accelerate the oxida-tion process but do not directly lead to fragmenta-tion.AcknowledgementsThis work was supported by the National Natural Sci-ence Foundation of China under a contract#50131030. Provision of high purity raw elements from Kyoto University is also appreciated.References[1]Rausch JJ.ARF-2981-4.Armour Research Foundation NSA1961,15-31171.[2]Pitman SH,Tsakiropoulos P.In:Horton J,editor.High-temper-ature ordered intermetallic alloys VI.J Mater Res Symp Proc,vol.364.Boston:Material Research Society;1995.p.1321.[3]Murakami T,Sasaki S,Ichikawa K,Kitahara A.Intermetallics2001;9:621.[4]Fitzer VE.Molybdenum disilicides as high-temperature materials,In:Plansee Proc.,2nd Seminar,Reutte/Tyrol1955.p.56.[5]Berkowitz JB,Rosetti M,Lee DW.Metall Trans1970;1:479.[6]Yanagihara K,Przybylski K,Maruyama T.Oxid Met1997;47:277.[7]Berkowitz-Mattuck JB,Blackburn PE,Felten EJ.Trans MetallSoc AIME1965;233:1093.[8]Meschter PJ.Metall Trans A1992;23:1763.[9]Zhang F,Zhang LT,Yu JX,Wu JS.Mater Sci Forum2005;475–479:729.[10]Westbrook JH,Wood DL.J Nucl Mater1964;12:208.[11]Schlichting J.High Temp High Press1978;10:241.[12]Fitzer E,Remmele W.In:Procfifth international conference oncomposite materials,AIME1985.p.515.[13]Mckamey CG,Tortorelli PF,DeVan JH,Carmichael CA.JMater Res1992;7:2747.[14]Berztiss DA,Cerchiara RR,Cerchiara EA,Pettit FS,Meier GH.Mater Sci Eng A1992;155:165.[15]Kurokawa K,Houzumi H,Saeki I,Takahashi H.Mater Sci Eng1999;A261:292.[16]Chou TC,Nieh TG.J Mater Res1993;8(1):214.。
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a r X i v :a s t r o -p h /9712023v 1 2 D e c 19971BeppoSAX observations of the X–ray binary pulsar 4U1626–67M.Orlandini a ,D.Dal Fiume a ,F.Frontera a ∗,S.Del Sordo b ,S.Piraino b ,A.Santangelo b ,A.Segreto b ,T.Oosterbroek c and A.N.Parmar caIstituto Tecnologie e Studio Radiazioni Extraterrestri (TeSRE),C.N.R.,via Gobetti 101,40129Bologna,ItalybIstituto Fisica Cosmica e Applicazioni all’Informatica (IFCAI),C.N.R.,via La Malfa 153,90146Palermo,ItalycAstrophysics Division,Space Science Department of ESA,ESTEC,Keplerlaan 1,2200AG Noordwijk,The NetherlandsWe report on observations of the low-mass X–ray binary 4U1626–67performed during the BeppoSAX Science Verification Phase.We present the broad-band 0.1–100keV pulse averaged spectrum,that is well fit by a two-component function:a 0.27±0.02keV blackbody and an absorbed power law with a photon index of 0.89±0.02.A very deep and narrow absorption feature at 38keV,attributable to electron cyclotron resonance,is clearly visible in the broad-band spectrum.It corresponds to a neutron star magnetic field strength of 3.3×1012G.The 4U1626–67pulse profiles show a dramatic dependance on energy:the transition between the low energy (E <10keV)bi-horned shape to the high-energy (E >10keV)sinusoidal profile is clearly visible in our data.The modulation index shows a monotonic increase with energy.1.INTRODUCTIONThe low-mass X–ray binary system 4U1626–67is formed by a neutron star pulsating at about 7.7s [1]and orbiting the faint blue star KZ TrA [2].This system shows the lowest mass function ever observed [3],putting severe constraints on the nature of the optical companion:the most likely is a 0.02–0.06M ⊙degenerate He or CO dwarf [4].The determination of the 4U1626–67orbital period have always been problematic:at-tempts to find Doppler delays in the X–ray pulse arrival times have always been unsuccessful,but photometric studies of the optical companion re-vealed the presence of two periods:one at the X–ray pulsation frequency [5]and another down-shifted by about 0.4mHz with respect to the first [6].Assuming that the optical emission is due to the reprocessing of the X–ray emission on the sur-face of the companion,a binary period of about 2500s and a projected semi-major axis of 0.4lt-s are inferred[7].2Table1Best-fit spectral parameters aNo Line Gaussian Lorenziana Uncertainties at the90%confidence level for a single parameter.b Flux is in units of10−2photons cm−2s−1at1keV.c The Ne line complex parameters are taken from[14].nent function:a blackbody with a temperaturekT∼0.6keV and an absorbed power law[15].A high energy cutoffat∼20keV is also necessary to describe the high energy data[16].This spectral function describes very well our data,both the single BeppoSAX NFIs spectra, and the broad-band spectrum.We used the stan-dard X–ray pulsar cutoffof the form exp[(E c−E)/E f],where E c and E f are the cutoffand fold-ing energy,respectively.The smoother Fermi-Dirac cutoffdid not adequately describe the high energy tail.After the inclusion of the Ne line complex at1keV[14]we obtained a bestfit with a reducedχ2νof1.482for348degrees of freedom (dof).From the analysis of the residuals we were led to add a cyclotron resonance feature(CRF) at∼35keV.Both a Lorenzian or a Gaussian in absorption model improved thefit,yieldingχ2νs of1.122and1.258for345dof,respectively.An F-test shows that the improvement is significant at 99.99%.Thefit results are summarized in Table1 [13].The search for a possible CRF at∼19keV, as suggested by Pravdo[16],was unsuccessful. The two CRF models are equivalent:the prob-ability of chance improvement from the Lorenzian to the Gaussian model is30%.However,we pre-fer the Gaussian description of the CRF,because the cutoffenergy in the Lorenzianfit is too close to the resonance energy.As it is evident from Table1,the Lorenzian model approximates the fall-offof the spectrum by increasing the cutoffenergy,and shifting the cyclotron energy at val-ues lower than those obtained by an absorption Gaussian.This is a known effect already observed for the CRF in Her X-1[17]and Vela X–1[18]. Our data do not show the presence of an Iron K-shell line in6.4–6.9keV:the upper limit on its equivalent width is21eV,slightly more stringent than the33eV value obtained by ASCA[19]. The total0.1–100keV X–ray luminosity is6.6×1034erg s−1d2kpc.Thefluxes in the bands0.5–10 and10–100keV are1.5×10−10and3.9×10−10 ergs cm−2s−1,respectively.4.TIMING ANALYSISThe pulse period referred to the Solar System barycenter is7.66790±0.00005s,in agreement3Figure1.4U1626–67pulse profiles as a function of energy observed by the MECS and PDS instruments aboard BeppoSAX.Note the transition between the bi-horned shape to the almost sinusoidal form, attained with the increase of the interpulse between the two horns as the energy increases.4Figure2.The modulation index as a function of energy computed from the4U1626–67pulse profiles shown in Fig.1.with BATSE results[20].We folded the Bep-poSAX MECS and PDS data in different energy bands with this period,and the results are plot-ted in Fig.1.We confirm the strong energy de-pendance of the4U1626–67pulse profile.The 2–10keV pulse shape presents the characteristic bi-horned form,but the interpulse is not asflat as previously observed:it shows the presence of a small peak.As the energy increases,this third peak increases until it completelyfills the inter-pulse,and the pulse profile becomes sinusoidal. 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