Predicting who rated what in large-scale datasets
To Clone or not to Clone
To Clone or not to Clone: The Ethical QuestionJoseph FarnsworthApril 7, 2000Apr 2000, updated 5 Dec 2001, Joseph Farnsworth, This paper cannot be reproduced without consent of its author.A couple that had been married for only two years was in a terrible caraccident. The wife walked away with a few cuts and bruises. The husband, however was unconscious when the paramedics arrived. He went into a coma shortly after arriving at the nearby hospital. He came out of the coma but was never to be the same again. It turns out that when he was in the accident he had severe head trauma, and would be a vegetable the rest of his life. He could not take part in the reproduction of children. The wife is now distraught because they will never have children together. She heard about the possibility of cloning and believes that it is the only way that she will ever have children. Is it so?IntroductionThe ethics of human cloning has become a great issue in the past few years. The advocates for both sides of the issue have many reasons to clone or not to clone. This is an attempt to explore the pros and cons of human cloning and to provide enough information of both sides of the arguments in order for the reader to make their own informed decision on whether human cloning is ethical or not. Cloning will first be defined. Then a brief explanation of why questions concerning cloning humans have arisen will be presented. Some things cannot be known for sure unless it is tested, i.e., human cloning is allowed. Followed by that, a discussion of the facts and opinions that support cloning will be presented and then the same againstcloning. Please remember that not all of this has proven true nor is able to be proven yet, but has simply been argued as a scientific hypothesis. Finally, my own personal opinion will be stated.Defining Human CloningWhen speaking of human cloning, what is meant? Different groups and organizations define it differently. To use a specific definition, the American Medical Association (AMA) defined cloning as “the production of genetically identical organisms via somatic cell nuclear transfer. …Somatic cell nuclear transfer‟ refers to the process which the nucleus of a somatic cell of an existing organism istransferred into an oocyte from which the nucleus has been removed” (Council on Ethical and Judicial Affairs 1). In other words, cloning is the method of produce a baby that has the same genes as its parent. You take an egg and remove its nucleus, which contains the DNA/genes. Then you take the DNA from an adult cell and insert it into the egg, either by fusing the adult cell with the enucleated egg, or by a sophisticated nuclear transfer. You then stimulate the reconstructed egg electrically or chemically and try to make it start to divide and become an embryo. You then use the same process to implant the egg into a surrogate mother that you would use with artificial insemination. (Eibert)However, many groups have used a broader definition of cloning. They include the production of tissues and organs through growing cells or tissues in cultures along with the actual producing of embryos to be born. This is done with the use of stem cells. When an egg is fertilized and begins to divide, the cells are all alike. As the cells divide, certain cells differentiate and become the stem cells that produce certain tissue and then organs. Research in this very active. There is still much for scientists to learn about cell differentiation and how it works. To a clone an organ, a stem cell must be produced and then used to a clone that specific organ. For the sake of this paper, both definitions will be used in order to cover all opinions.One must understand that cloning does not produce an exact copy of the person being cloned. What cloning does, is that it copies the DNA/genes of the person and creates a duplicate genetically. The person will not be a Xerox copy. He or she will grow up in a different environment than the clone, with different experiences and different opportunities. Genetics does not wholly define a person and the personality.How It All StartedIn February 1997, when embryologist Ian Wilmut and his colleagues at Roslin Institute in Scotland were able to clone a lamb, named Dolly, the world was introduced to a new possibility and will never be the same again (Nash). Before this, cloning was thought to be impossible, but now there is living proof that the technology and knowledge to clone animals exist. Questions began to arise within governments and scientific organizations and they began to respond. Are humans next? Is it possible to use this procedure to clone humans also? Would anyone actually try? What can we learn if we clone humans? How will this affect the world? These are only a few of the questions that have surfaced and need answered. A whole new concept in ethics was created when the birth of Dolly was announced.There are a great number of possible medical benefits and disadvantages to cloning and its technology. They include the following:Potential Medical Benefits•T he possibility that through cloning technology we will learn to renew activity of damaged cells by growing new cells and replacing them.•T he capability to create humans with identical genetic makeup to act as organ donors for each other, i.e., kidney and bone marrow transplants.•T he benefit of studying cell differentiation at the same time that cloning is studied and developed.•S terile couples will be able to have offspring will have either the mother‟s or father‟s genetic pattern.Potential Harms and Disadvantages•T he possibility of compromising individualities.•L oss of genetic variation.•A “black market” of fetuses may arise from desirable donors that will want to be able to clone themselves, i.e., movie stars, athletes, and others.•T echnology is not well developed. It has a low fertility rate. In cloning Dolly, 277 eggs were used, 30 started to divide, nine induced pregnancy, andonly one survived to term (Nash).•C lones may be treated as second-class citizens.•U nknown psychosocial harms with impacts on the family and society.The Governments Make a MoveThe governments went to work shortly after the cloning of Dolly. They wanted to take control and make laws before anything drastic could ever happen. Several ethics committees were asked to decide whether scientists should be allowed to try to clone humans. Many of the committees found the data displayed above. In the United States, the National Bioethics Advisory Commission recommended a five-year moratorium on cloning a child through somatic cell nuclear transfer (Council on Ethical and Judicial Affairs 1). In the state of Michigan, Governor Engler signed a law last year making human cloning illegal with harsh penalties if it is attempted (“Governor Engler...”). In the United Kingdom, the Human Fertilisation and Embryology Authority (HFEA) and the Human Genetics Advisory Commission (HGEC) have approved human cloning for therapeutic purposes, but not to clone children (“HFEA supports Human Cloning in U.K.”). Many organizations have come out and stated their opinions also. Amongst all this ethical defining, many people are being ignored by the governments. People are speaking out about what they want done.Let Us CloneAfter a couple has had their first child, to their disappointment they become infertile and cannot have more children. Cloning would enable such a couple to have a second child, perhaps a younger twin to the child they already have. This example has a very good argument. Many couples have difficulties having children, and sometimes it is impossible for couples to have children because they areinfertile. Cloning would allow these couples to have children. Also, occasionally a woman is born without a uterus or has other complications and cannot produce eggs, then with the help of a surrogate mother, she can have a child of her own using her own DNA or her husband‟s.This and the example at the beginning are both arguments that some have made in promoting cloning. It is hard to tell someone that they cannot use cloning to have children when no other possible ways to produce offspring are available. This is one reason why it is difficult to decide if cloning is ethical or not. The following are some of the reasons why cloning should be allowed.As just discussed, cloning can be used to help benefit those that are sterile and cannot have children through the normal, natural way. It is the desire of most couples to have children and when it is impossible to bare children of your own, some are willing to do anything to have a child. Cloning will allow them to have a child or many children that have the genetic pattern of one of the parents.Through cloning, research can progress. It is hard to say what we can learn from cloning if cloning is not allowed. We possibly can learn more about cell differentiation. We can learn enough to produce human organs without having to produce human beings. We may develop technology to allow easier genetic testing and fixing problems such as spinal cord injuries, cancer, Tay-Sachs disease, and many more.Cloning organs for organ transplants is one of the major practical reasons that cloning should be allowed. There is always a high demand for organs. Some argue for the cloning of humans to create spare body parts. Others talk of just wanting to clone an organ to replace a defective organ.Rejuvenation is also a key argument for advocates of cloning. Human cloning may one day reverse heart attacks. Some scientists believe that by injecting cloned healthy heart cells into damaged heart tissue will lead to healing of the heart (Human Cloning Foundation). By combining the technology for cloning and the technology for growing human stem cells, conditions like Alzheimer=s disease, Parkinson=s disease, and degenerative joint disease may be curable. The possibilities are endless and may be left undiscovered if human cloning is banned.Thou Shalt Not CloneOne of the main goals of the government is to protect human life. Some people want the government to regulate cloning and not allow it. Michigan=s government believes this and became the first government to place a ban on cloning. As mentioned before, the governor signed laws that prohibit engaging or attempting to engage in human cloning. A Michigan state senator, Mr. Bennett said, “This legislation boils down to one thing: Prohibiting the creation of human life forscientific research. Human cloning is wrong; it will be five years from now; and wrong 100 years from now!” (“Governor Engler...”) Producing clones for researchor to use their parts is unethical. It would be against the code of ethics of a doctor to harm a clone (i.e., use it for an organ transplant). The clone would be a human being and deserve all the rights and privileges that a non-cloned human has. A clone should not be a second-class citizen. It is speculated that they would be considered as such.The American Medical Association holds four points of reason why cloning should not take place. They are: 1) there are unknown physical harms introduced by cloning, 2) unknown psychosocial harms introduced by cloning, including violations of autonomy and privacy, 3) impacts on familial and societal relations, and 4) potential effects on the human gene pool (Council on Ethical and Judicial Affairs 4-6). We just simply do not know the harms that will come from cloning.Cloning would lead to the loss of individuality because one=s genetic predispositions and conditions would be known. If raised by a clone-parent or as a sibling to the cloned, one may have great expectations to live up to. However, the human clones could differ greatly in personality and even grow up with different conditions than the cloned. Even monozygotic twins differ. This could be a great stress to the clone and possibly even the loss of ability to chose for itself (Council on Ethical and Judicial Affairs 5).The long term genetic effects of cloning may cause more problems than can be imagined. The question of what can go wrong in cloning needs to be discussed. In an evolutionary standpoint, cloning is not good. Evolution relies on a continual mixing and matching of genes to keep the gene pool alive (McCormack). With cloning, the natural process of selection of genes would be bypassed and evolution would be impaired. The Council of Ethical and Judicial Affairs for the AMA stated the following concerning possible problems with mutations and clones:Since the somatic cell from which clones originate likely willhave acquired mutations, serial cloning would compound theaccumulation that occurs in somatic cells. Although thesemutations might not be apparent at the time of cloning, geneticsproblems could become exacerbated in future generations.(Council on Ethical and Judicial Affairs 6)We can see that cloning can possibly change the gene pool from how we now know it. Most likely, it would not be a good change.Technology as we presently know it will not effectively support the cloning of humans. As mentioned before, the success rate was quite low when cloning Dolly. Only one of the 277 tries succeeded, see chart 1. The same problems of the difficulty of having the fertilized egg implant parallels with that in in vitrofertilization. Technology has not yet been able to provide an answer to this problem.The fear that clones will be treated as second-class citizens is also present. If a clone is created to act as bone marrow or kidney donor, the question arises if they would be treated like the first child? Would the parents even love this child the same? If not, this would lead to negative self-esteem and/or other physiological problems.There is also the fear that some would want to clone people to create large armies of the same soldier or even produce large amounts of workers. This would also lead to the creation of a second and lower class for clones.From a Latter-day Saint point of view, the Proclamation on the Family clearly does not agree with cloning. The Proclamation states: “We . . . declare that God has commanded that the sacred powers of procreation are to be employed only between man and woman, lawfully wedded as husband and wife. We declare the means by which mortal life is created to be divinely appointed. We affirm the sanctity of life and of its importance in God‟s plan.” (Italics added) In other words, the power to create humans is only to be used in a marriage between husband and wife. Cloning only involves one parent, therefore it is not following God‟s plan in which a man‟s sperm and a woman‟s egg are needed to create l ife.My Personal RecommendationAs a student studying biology, I have tried to approach both sides and approach them with an unbiased opinion. I personally think that the world of genetics is fascinating, but after learning of what is now possible through technology, I changed my mind about pursuing a career in the field. I see cloning as a wonderful advancement in technology and knowledge. I do not think it should be used to reproduce humans though. I do not believe that we should try to develop other ways beside the natural way to bring life into this world. I strongly believe that God created us and that we are subjected to His laws and must obey. The laws of God that have the worst punishment deal with bringing life into the world and taking life out of the world. I believe that cloning people would fall under these laws also.Cloning tissues and organs falls under a different category that cloning human beings. I think it would be advantageous to science and medicine to clone tissues and organs. However, the research in this involves fetal tissue which is a completely different ethical discussion. I do not know enough about the procedure be against it. So, with my present understanding I would allow cloning for tissues and organs. ConclusionCloning can revolutionize the world and the way we live or it may be so minimal that it would not affect us at all if it is allowed. [Two sentences taken out during update.] Is this the world you want to live in? Each person individually must decide for himself or herself if they believe that cloning should be allowed or if thegovernments should intervene with it.WHY CLONE?Research advances over the past decade have told us that, with a little work, we humans can clone just about anything we want, from frogs to monkeys and probably even ourselves!So, we can clone things, but why would we want to? Let's look at some of the reasons people give to justify cloning.1. Cloning for medical purposesOf all the reasons, cloning for medical purposes has the most potential to benefit large numbers of people. How might cloning be used in medicine?▪Cloning animal models of diseaseMuch of what researchers learn about human disease comes from studying animal modelssuch as mice. Often, animal models are genetically engineered to carry disease-causingmutations in their genes. Creating these transgenic animals is a time-intensive process thatrequires trial-and-error and several generations of breeding. Cloning technologies mightreduce the time needed to make a transgenic animal model, and the result would be apopulation of genetically identical animals for study.▪Cloning stem cells for researchStem cells are the body's building blocks, responsible for developing, maintaining andrepairing the body throughout life. As a result, they might be used to repair damaged ordiseased organs and tissues. Researchers are currently looking toward cloning as a way tocreate genetically defined human stem cells for research and medical purposes. To see howthis is done, see Creating Stem Cells for Research, a component of the Stem Cells in theSpotlight module.▪"Pharming" for drug productionFarm animals such as cows, sheep and goats are currently being genetically engineered toproduce drugs or proteins that are useful in medicine. Just like creating animal models ofdisease, cloning might be a faster way to produce large herds of genetically engineeredanimals. Find out more about this research in the feature article Pharming for Farmaceuticals.2. Reviving Endangered or Extinct SpeciesHave you seen Jurassic Park? In this feature film, scientists use DNA preserved for tens of millions of years to clone dinosaurs. They find trouble, however, when they realize that the cloned creatures are smarter and fiercer than expected.Could we really clone dinosaurs?In theory? Yes. What would you need to do this?▪ A well-preserved source of DNA from the extinct dinosaur, and▪ A closely related species, currently living, that could serve as a surrogate motherIn reality? Probably not. It's not likely that dinosaur DNA could survive undamaged for such a long time. However, scientists have tried to clone species that became extinct more recently, using DNA fromwell-preserved tissue samples. For an example, see "Can we really clone endangered or extinct animals?" on the right side of this page.3. Reproducing a Deceased PetNo joke! If you really wanted to, and if you had enough money, you could clone your beloved family cat. At least one biotechnology company in the United States offers cat cloning services for the privileged and bereaved, and they are now working to clone dogs. But don't assume that your cloned kitty will be exactlythe same as the one you know and love. Why not? See Cloning Myths.4. Cloning Humans?To clone or not to clone: that is the question. The prospect of cloning humans is highly controversial and raises a number of ethical, legal and social challenges that need to be considered. To explore some of these, see What are Some Issues in Cloning?Why would anyone want to clone humans? Some reasons include:▪To help infertile couples have children▪To replace a deceased childFrom a technical standpoint, before humans are cloned, we need to have a good idea of the risks involved. How sure can we be that a cloned baby will be healthy? What might go wrong? To evaluate the technical challenges to cloning, see Risks of Cloning.Supported by a Science Education Partnership Award (SEPA) [No. 1 R25 RR16291-01] from the National Center for Research Resources, a component of the National Institutes of Health, Department of Health and Human Services. The contents provided here are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH.。
2019年上海市春考高考英语真题试卷(精校Word版含答案)【可修改文字】
可编辑修改精选全文完整版上海市普通高校春季招生统一文化考试第I卷(共100分)I. Listening ComprehensionSection ADirections: In Section A, you will hear ten short conversations between two speakers. At the end of each conversation, a question will be asked about what was said. The conversations and the questions will be spoken only once. After you hear a conversation and the question about it, read the four possible answers on your paper, and decide which one is the best answer to the question you have heard.1. A.Her working all day long. B.The family reunion.C.The annoying housework.D.The intense schedule.2. A.The kids were frightened by the movie.B.The kids enjoyed the movie.C.The movie is not suitable for kids to see.D.The movie is quite boring.3. A.She is drinking tea at a table. B.She is interested in reading magazines.C.She likes the pictures in the magazines.D.She doesn’t know any Chinese.4. A.Supermarket. B.Drug store. C.Barber shop. D.Shopping center.5. A.He likes cooking food himself. B.He thinks frozen food is healthier.C.He accepts the woman’s invitation.D.He prefers to buy frozen food.6. A.A full-time student. B.An exchange student.C.A visiting scholar.D.A part-time student.7. A.She is bossy. B.She is shy.C.She is arrogant(傲慢的).D.She is trustworthy.8. A.He’s a teacher. B.He’s a writer.C.He’s a businessman.D.He’s a journalist.9. A.1 hour. B.2 hours. C.3 hours. D.4 hours.10. A.The bad weather stopped him. B.His shoes were worn out.C.He didn’t like the hiking trip.D.He’s too tried to continue.Section BDirections: In Section B,you will hear two passages and one longer conversation.After each passage or conversation,you will be asked several questions.The passages and conversation will be read twice,but the questions will be spoken only once.When you hear a question,read the four possible answers on your paper and decide which one is the best answer to the question you have heard.Questions 11 through 13 are based on the following passage.11. A.They became more active in water.B.Symptoms of depression disappeared.C.Their digestion developed.D.They suffered from depression.12. A.Neon lights. B.Kindle screens.C.Overweight.D.Closed window curtains.13. A.Turn off all the electronic devices. B.Read a book and drink some water.C.Take some sleep pills.D.Go on a diet and lose some weight. Questions 14 through 16 are based on the following passage.14. A.71% of the poor live a day with less than ten dollars.B.The population of people live in poverty has decreased in the past decade.C.Economic growth has made global poverty worse than before.D.The middle class are now one step away from poverty.15. A.The middle class has expanded in the 111 countries.B.The number of middle class has increased but it is not a global phenomenon.C.Great progress has been made for the people in poverty with impressive results.D.Once getting out of poverty,those people will live a better life.16. A.The middle class would not allow those poor to make a better living.B.Whatever progress is made,nothing will be changed.C.Good changes are too tiny to make those poor live a totally different life.D.Developed countries suffer from the question from both poverty and the middle class. Questions 17 through 20 are based on the following conversation.17. A.A thunderstorm accident. B.A cable emergency.C.An appointment on Saturday.D.A computer system breakdown.18. A.Lightning. B.Power failure. C.Cable cut. D.System failure.19. A.Plug the TV off. B.Keep the cable connected.C.Stay at home.D.Call the cable center for sure.20. A.On Saturday morning. B.On Saturday afternoon.C.On Tuesday morning.D.On Tuesday afternoon.II. Grammar and VocabularySection ADirections: After reading the passage below, fill in the blanks to make the passages coherent and grammatically correct. For the blanks with a given word, fill in each blank with the proper form of the given word; for the other blanks, use one word that best fits each blank.My Kid-Free LifeI had expected to have more free time after my sons,Evan and Alex,each left for college,and I do.The kitchen calendar looks spare.Rarely (21)__________ I need to prepare family dinner every day.There is a lot (22)__________ (little) laundry.When the boys were infants,I wondered how I (23)__________ (spend) all the hours before they were born.(24)__________ __________ I have those hours back,I can focus on my own needs.I had also expected to worry about them when they were away.And I do.Did they get their flu shots(流感疫苗注射)?Will they remember the talks about “good choices”?On the other hand,the worry is mixed with relief.I have seen (25)__________ vigorously they grow without me.Do I missed them?Yes.Both more and less than I’d guessed.Do I feel united for having lost myprimary role in life?No,because over the year,I took great pride (26)__________ the fact that my identity was not dependent on theirs.But,surprisingly,yes.(27)__________ (be) a different kind of mother defines me now.The missing comes at unexpected moments:seeing the school bus drive by,starting to put too many plates on the table...When they have doubts about friendships or job prospects,I can only say, “I’m sure you will figure it out.”And yet,the spaces (28)__________ (empty) by loss are more than filled by what I’ve found.I now have the chance (29)__________ (see) them as the whole world does but also like no one else ever will.As adults I happened to help create.The rooms (30)__________ the boys used to live look vacant.I feel sadness but also joy.I knew they would leave,but they will find their way back.My home is empty.But overflowing.Section BDirections: Complete the following passage by using the words in the box. Each word can only be used once. Note that there is one word more than you need.Palaces are known for their beauty and splendor, but they offer little protection against attacks. It’s easy to defend a fortress(堡垒),but fortresses are not designed with the comfort of a king or queen in mind. When it comes to structures that are both (31)__________ and well-fortified, the classic Europe castle is the pinnacle(小尖顶) of design. Across the ages castles changed, developed, and eventually fell out of use, but they still command the (32)__________ of our culture.Castles were (33)__________ built in England by Norman invaders in 1066. As William the Conqueror (34)__________ through England, he fortified key positions to secure the land he had taken. The castles he built allowed the Norman lords to retreat to safety when threatened by English (35)__________. Castles also served as bases of operation for offensive attacks. Troops were summoned to, organized around, and deployed from castles. In this way castles served both (36)__________ and defensive roles in military operations.Not limited to military purposes, castles also served as offices from which the lord would administer control over his fiefdom(领地). That is to say, the lord of the land would hold court in his castle. Those that were socially beneath the lord would come to report the affairs of the lands that they (37)__________ and pay tribute to the lord. They would (38)__________ disputes, handle business, feast, and enjoy festivities. In this way castles served as important social centers in medieval England. Castles also served as symbols of power. Built on prominent sites (39)__________ the surrounding areas, castles constantly loomed in the background of many peasants' lives and served as a daily (40)__________ of the lord's strength.III. Reading ComprehensionSection ADirections: For each blank in the following passages there are four words or phrases marked A, B, C and D. Fill in each blank with the word or phrase that best fits the context.Humans hate markedly to give workers more than they deserve,and indeed many will settle for less to compensate work equitably.But is this impulse (41)__________?Perhaps not,says psychological scientist Marie Schafer in Germany.According to Schafer,nobody has ever looked at how young children from different (42)__________ think about merit when sharing rewards.There is reason to suspect that meritocracy may be more of a Western concept and value,so she and several colleagues decided to put this to the test,studying the (43)__________ of children,four to 11 years old,in three different cultures.The idea was to test how much the children valued merit.So each child was given a number of sweets equal to the total number of fish in the catch,and was told to distribute the sweets any way he or she wanted—without adults in the room to influence them.If they valued merit,children should (44)__________ the sweets according to shares of the catch.That is,if they had landed the same number of fish,they wold choose to reward each one (45)__________,but if one fared much better at fishing,rewards would also be disproportionate.In the case where they were simply given the fish,rewards should be unrelated to catch size—since no effort was involved.(46)__________ matters.That’s the main finding among many from the study,as described in a forthcoming issue of the journal Psychological Science.The German children distributed the spoils of the day precisely in proportion to (47)__________,even when this meant a very unbalanced distribution of rewards.By contrast,children from the two rural African forager(狩猎) societies barely took merit into consideration at all.These findings suggest that the basic notion of merit and distributive justice is far from universal in our species,and that (48)__________ is culturally defined.But why?The scientists offer some (49)__________ on this.It could be that in large-scale societies like Germany,a meritocracy is (50)__________ for regulating transactions between people who don’t know each other and may not interact again.The focus is on equitable interactions,because things won’t be “evened out”in the future.In small scale societies,(51)__________,most exchanges take place between people who are (52)__________ with one another.It may be more important in such societies to build long-term relationships based on equity—rather than to insist on equity in a single transaction.In egalitarian forager societies,such as the Haillom,(53)__________ is an important leveling mechanism,(54)__________ asymmetries in wealth and increasing harmony.Children may internalize these social values early on,and apply them even when the fishing trip is (55)__________.41. A.unblocked B.universal C.unconscious D.unique42. A.cultures B.cases panies D.aspects43. A.mood B.behavior C.emotion D.habit44. A.collect B.load C.stress D.distribute45. A.really B.deliberately C.equally D.happily46. A.Scene B.Object C.Culture D.Trend47. A.productivity B.benefit C.interest D.survey48. A.tiredness B.business C.thickness D.fairness49. A.feelings B.thoughts C.lives D.emotions50. eful B.major C.small D.important51. A.in a word B.in addition C.by contrast D.what’s more52. A.familiar B.delighted C.satisfied D.same53. A.cooperating B.smiling C.equaling D.sharing54. A.forcing B.judging C.balancing D.experiencing55. A.creative B.imaginary C.innovative D.logicSection BDirections: Read the following three passages. Each passage is followed by several questions or unfinished statements. For each of them there are four choices marked A, B, C and D. Choose the one that fits best according to the information given in the passage you have read.(A)We Have a Painter to Thank for YellowstoneBefore artist Thomas Moran set foot in the park,it was seen as an unhappy place.After,it was market as a wonderland.Before Thomas Moran arrived,Yellowstone in the popular imagination was a harsh,will place pocked with hellish geysers.After the painter’s work was finished,Yellowstone was established as a national park and marketed as a wonderland.In 1871 Moran and photographer William Henry Jackson had joined the first U.S. government survey of the region.For two weeks Moran filled a sketchbook with the landscape’s most stunning sights.The survey results,Jackson’s photos,and Moran’s watercolors—the first color renderings of the area—were presented to Congress that fall. “The photographs were proof that what the artist was showing really existed,”says Eleanor Harvey,senior curator at the Smithsonian American Art Museum.In March 1872 lawmakers officially made Yellowstone a national park,the world’s first.By April,Moran had transformed some of his sketches into a 7-by-12-foot painting.The gold-splattered valley and billowing Lower Falls of “The Grand Canyon of the Yellowstone”attracted the public. “It is too grand and wonderful for words,”declared the Ladies’Repository that August, “and none can ever judge of its wonders from any engraving or photograph in mere black and white.”Though Moran later painted Lake Superior,the Grand Canyon,and the Rockies,hsi reputation was so intertwined with Yellowstone that he took to signing his paintings “TYM,”for Thomas “Yellowstone”Moran.56.What can we know about Yellowstone according to the passage?A.It was a popular park with geysers before Thomas Moran finished transformation.B.It was an imagination of a harsh and wild place.C.It became a national park with the efforts of Moran and Jackson.D.It is an attractive grand valley.57.What does the “pocked” mean in the first sentence (paragraph 2)?A.Packed.B.Dotted.C.Blocked.D.Stuck.58.What are the characteristics of Thomas Moran’s paintings about Yellowstone Park?A.Paying attention to color rendering of paintings.B.His magnificent and wonderful paintings.C.His reputation closely linked to Yellowstone Park.D.His paintings with nothing special.59.What does the passage mainly talk about?A.The Significance of Thomas Moran’s paintings to Yellowstone Park.B.How Yellowstone Park is established as a National Park.C.The Great Painter—Thomas Moran.D.The process of Yellowstone Park being labelled as a fairyland.(B)Why UPS Trucks (Almost) Never Turn LeftBy favoring right-hand turns at all times—unless a left is unavoidable—the carrier saves millions of gallons of fuel each year,and avoids emissions equivalent to over 20,000 passenger cars.The practice started decades ago,before computers and GPS,and is now managed by a software that conjures the most efficient route for each truck.What’s wrong with turning left?Left-hand turns are generally considered unsafe and wasteful on right-hand driving roads,such s those in the U.S.“Left-turning traffic typically has to turn against a flow of oncoming vehicles,”explains Tom Vanderbilt,author of the book “Traffic:Why we drive the way we do.”“This can not only be dangerous,but makes traffic build up,unless you install a dedicated left-turn ‘phase’,which is fine but basically adds 30 or 45 seconds to everyone else’s single time,”he said.A study on crash factors in intersection-related accidents from the U.S. National Highway Traffic Safety Association shows that turning left is one of the leading “critical pre-crash events”(an event that made a collision inevitable),occurring in 22.2 percent of crashes,as opposed to 1.2 percent for right turns.About 61 percent of crashes that occur while turning or crossing an intersection involve left turns,as opposed to just 3.1 percent involving right turns.Left turns are also three times more likely to kill pedestrians than right ones,according to data collected by New York City’s transportation planners.The right way to save fuel“A left-hand turn is also less fuel efficient,”said Jack Levis,UPS Senior Director of Process Management, “because your car’s idling(未熄火) longer,which is also not good for your vehicle.”(此处应有图片)UPS does not ban left turns outright,says Levis: “We will make left hand turns,but not ones that are unnecessary.We don’t need to go in circles all day long by making only right hand turns.We have tools analyze the number of left hand turns for each route,and we can work out which ones are avoidable.”The procedure is now incorporated in most countries around the world.To this end,the carrier created its own maps,which it says are more accurate that commercially available ones: “We can differentiate more important left-hand turns from unimportant ones.Google Maps has no concept of not making a left-hand turn,it just shows the most direct way to reach your destination.We have the ability to penalize some of those,”Levis told CNN.The system knows about parking lots,private driveways,variable speed limits and roads that are inaccessible for a truck.The software can give an undesirable left turn a penalty that adds 20 seconds to the estimated route time.In that case,going around the block and turning always right might offset that 20-second penalty: “We were able to turn off left hand turns,” said Levis.Taking a longer route while still saving time and fuel might sound confusing,even to UPS drivers,according to Vanderbilt: “I’ve actually been to UPS’s logistics center and discussed this with their lead engineers,”he said.“A lot of individual drivers felt the new routing software was making their trips longer,but they were later proven wrong.This is the thing about traffic,it’s such a complex system that often the individual cannot get a sense of the overall efficiency of the system,and optimize accordingly.It’s also one of the counter intuitive, ‘slower-is-faster’ effects you often see in traffic.”The rule,says Levis,can also be applied to left-hand driving countries,such as Australia and the UK,where it discourages right-hand turns.60.How much resources can UPS trucks save by avoiding turning left?A.UPS trucks will consume millions of gallons of fuel.B.The emission of UPS trucks is equivalent to that of over 2000 passenger cars.C.UPS trucks estimate to save 100,000 metric tons of CO2 emission a year.D.UPS trucks estimate an increase of 6 to 8 miles per route.61.In Tom Vanderbilt’s View,how to Deal with the Left Turn Problem in the United States?A.Install a dedicated left turn phase.B.Traffic planners manage road conditions.C.Operators make their own traffic maps.D.National policy encourages left turn of vehicles.62.Which of the following options is NOT TRUE according to the passage?A.It’s unsafe to turn left on right-hand driving roads.B.Turning left is resource-efficient on right-hand driving roads.C.Left turning is likely to cause traffic accidents.D.Left-turn is discouraged in all countries.(C)“Is data the new oil?”asked proponents of big data back in 2012 in Forbes magazine.By 2016,and the rise of big data’s turbo-powered cousin deep learning,we had become more certain: “Data is the new oil,”stated Fortune.Amazon’s Neil Lawrence has a slightly different analogy:Data,he says,is coal.Not coal today,though,but coal in the early days of the 18th century,when Thomas Newcomen invented the steam engine.A Devonian ironmonger,Newcomen built his device to pump water out of the south west’s prolific tin mines.The problem,as Lawrence told the Re-Work conference on Deep Learning in London,was that the pump was rather more useful to those who had a lot of coal than those who didn’t:it was good,but not good enough to buy coal in to run it.That was so true that the first of Newcomen’s steam engines wasn’t built in a tin mine,but in coal works near Dudley.So why is data coal?The problem is similar:there are a lot of Newcomens in the world of deep learning.Startups like London’s Magic Pony and SwiftKey are coming up with revolutionary new ways to train machines to do impressive feats of cognition,from reconstructing facial data fromgrainy images to learning the writing style of an individual user to better predict which word they are going to type in a sentence.And yet,like Newcomen,their innovations are so much more useful to the people who actuall copious(丰富的) amounts of raw material to work from.And so Magic Pony is acquired by Twitter,SwiftKey is acquired by Microsoft and Lawrence himself gets hired by Amazon from the University of Sheffield,where he was based until three weeks ago.But there is a coda to the story:69 years later,James Watt made a nice tweak to the Newcomen steam engine,adding a condenser to the design.That change,Lawrence said, “made the steam engine much more efficient,and that’s what triggered the industrial revolution.”Whether data is oil or coal,then,there’s another way the analogy holds up:a lot of work is going into trying to make sure we can do more,with less.It’s not as impressive as teaching a computer to play Go or Pac-Man better than any human alive,but “data efficiency”is a crucial step if deep learning is going to move away from simply gobbling up oodles of data and spitting out the best correlations possible.“If you look at all the areas where deep learning is successful,they’re all areas where there’s lots of data,”points out Lawrence.That’s great if you want to categorize images of cats,but less helpful if you want to use deep learning to diagnose rare illnesses. “It’s generally considered unethical to force people to become sick in order to acquire data.”63.According to the passage,why data is seen as the new coal?A.It can drive the steam engine to pump water.B.It can help people make more coals.C.It can help the areas of deep learning.D.It can help cure diagnose rare illnesses.64.According to Lawrence,why big data is less helpful to diagnose rare illnesses?A.Because there is no such demand.B.Because it can only use to categorize images of cats.C.Because it’s unethical to acquire data by forcing people to become sick.D.Because it needs too much data.65.Which areas are most likely to be successful in in-depth learning?A.Some small start-ups.B.Areas with large amounts of data.C.Coal and Petroleum Development Field.D.Areas for tackling rare diseases.66.According to the content of the article,which is NOT TRUE about the big data?A.We still have a lot of work to study the big data.B.It requires countless data to be collected.C.The purpose of studying big data is to save parents’ costs.D.“Data efficiency” is a critical step to explore more data.Section CDirections: Read the following passage. Fill in each blank with a proper sentence given in the box.Shared decision making requires you to be an active participant.Politicians and policymakers are discussing what parts of the Affordable Care Act to change and what to keep.While most of us have little control over those discussions,there is one health care topic that we can control:what we talk about with our doctor.The Institute of Medicine (IOM) released the landmark publication Crossing the Quality Chasm 15 years ago.The report proposed six aims for improvement in the U.S. health system,identifying that health care should be patient-centered,safe,effective,timely,efficient and equitable.The idea that health care should be patient-centered sounds obvious,but what does that mean?The IOM defines it as care that is “respectful of and responsive to individual patient preferences,needs,and values”and that ensures “patient values guide all clinical decisions.”For this to truly happen,doctors’ appointments need to cover more topics than how one is feeling and what can be done.Does your doctor know your values?(67)__________ Fewer than half of people report that their physician or other health care provider asks about their goals and concerns for their health and health care.Your doctor can discuss medical tests and treatments without knowing your life goals,but sharing your values and needs with your doctor makes discussions and decisions more personalized and may lead to better health.How does patient-centered care happen?In order for your health care to center around you,your doctor needs to know your values,preferences and needs.Everyone is different.(68)__________As a neurologist,when I’m working with a 76-year-old widow whose main goal is to remain independent in her home,we frame her care in that context.(69)__________ We discuss how a walker helps her be more independent rather than less,as she can move around her home more safely.When a stressed college student comes to my office for a bothersome tremor,his preference is to avoid medications that he might forget to take or that might harm his school performance.This guides our discussion of the pros and cons of different options,including using medications but also doing nothing,an option that almost half of patients feel strongly should always be discussed.(70)__________ In sharing their values and goals with me,these individuals enabled a health care approach that respected their needs and also responded to their life circumstances.IV. Summary WritingDirections:Read the following passage. Summarize the main idea and the main point(s) of the passage in no more than 60 words. Use your own words as far as possible.To Laugh Is HumanMost of us don’t know why we laugh at some jokes and not at others.Scientists know that we are able to laugh at birth.Babies begin to laugh at three to four months of age,well before they produce their first words.What scientists are interested in is why we laugh.Scientists believe humans laugh with others primarily because it makes us feel connected with one another,which in turn gives us a sense of trust and comfort.To scientists,laughter is anunconscious reaction;consequently,when we laugh,others can be certain that it is an hones reaction,and honesty is key when building and maintaining friendships.Since laughter is seen as a social signal that we send to others,it can also help explain why it is so infectious.Studies have proven that when people see or hear something funny,they are 20 times more likely to a laugh when they are with others than when they are alone.Wanting to be accepted by others is part of human nature.And mirroring other people’s laughter is a way to signal to others that you feel the way they do,which makes us feel more connected with one another. Humans have not always laughed just so they can feel closer to others,however.Scientists point out that this social function of laughter was born out of an even more fundamental human ughter,they believe,came about because it contributed to our very survival as a species.Scientists assume that sharing laughter ensured our ancestors a higher survival rate because it led to greater cooperation between individuals.Humans learned quickly that greater cooperation led to survival,and the brain in turn realized that laughing with others increased out chances of finding people to cooperate,hunt,eat,live,and eventually,survive with.第II卷(共40分)V. TranslationDirections: Translate the following sentences into English, using the words given in the brackets.1.少喝含糖饮料,否则你会容易发胖。
高考英语阅读理解专项训练——科技类
2009高考英语阅读理解专项训练——科技类(1)With only about 1, 000 pandas left in the world, China is desperately trying to clone(克隆) the animal and save the endangered species(物种). That’s a move similar to what a Texas A & M University researchers have been undertakin g for the past five years in a project called “Noah’s Ark”.Noah’s Ark is aimed at collecting eggs, embryos(胚胎), semen and DNA of endangered animals and storing them in liquid nitrogen. If certain species should become extinct, Dr. Duane Kraemer, a profes sor in Texas A & M’s College of Veterinary Medicine, says there would be enough of the basic building blocks to reintroduce the species in the future.It is estimated that as many as 2, 000 species of mammals, birds reptiles will become extinct in over 100 years. The panda, native only to China, is in danger of becoming extinct in the next 25 years.This week, Chinese scientists said they grew an embryo by introducing cells from a dead female panda into the egg cells of a Japanese white rabbit. They are now trying to implant the embryo into a host animal.The entire procedure could take from three to five years to complete.“The nuclear transfer(核子移植) of one species to another is not easy, and the lack of available(capable of being used) panda eggs could be a major problem,” Kraemer believes. “They will probably have to do several hundred transfers to result in one pregnancy (having a baby). It takes a long time and it’s difficult, but this could be groundbreaking science if it works. They are certainly n ot putting any live pandas at risk, so it is worth the effort,” adds Kraemer, who is one of the leaders of the Project at Texas A& M, the first-ever attempt at cloning a dog.“They are trying to do something that’s never been done, and this is very simila r to our work in Noah’s Ark. We’re both trying to save animals that face extinction. I certainly appreciate their effortand there’s a lot we can learn from what they are attempting to do. It’s a research that is very much needed.”1. The aim of “Noah’s Ark” project is to _______.A. make efforts to clone the endangered pandasB. save endangered animals from dying outC. collect DNA of endangered animals to studyD. transfer the nuclear of one animal to another2. According to Professor Kraemer, the major problem in cloning pandas would be the lack of _______.A. available panda eggsB. host animalsC. qualified researchersD. enough money3. The best title for the passage may be _______.A. China’s Success in Pandas CloningB. The First Cloned Panda in the WorldC. Exploring the Possibility to Clone PandasD. China —the Native Place of Pandas Forever4. From the passage we know that _______.A. Kraemer and his team have succeeded in cloning a dogB. scientists try to implant a panda’s egg into a rabbitC. Kraemer will work with Chinese scientists in clone researchesD. about two thousand of species will probably die out in a century【答案解析】本文讲述中国正在竭力克隆濒临绝种的熊猫,这和Texas A & M University 的Noah's Ark(诺亚方舟)工程极为相似,都是想拯救濒临灭绝的动物。
2024届湖北省武汉市新洲区第一中学(阳逻)高三下学期第六轮模拟考试英语试题
2024届湖北省武汉市新洲区第一中学(阳逻)高三下学期第六轮模拟考试英语试题一、阅读理解Aptitude Tests RecommendationsAptitude tests are helpful to job seekers of all ages. While career quizzes explore your values and work style, aptitude tests provide a more objective evaluation of your skills, helping you select a career you’re most likely to succeed in. Below are some of the best aptitude tests out there.Clifton StrengthsThe Clifton Strengths program was created based on research around leadership. The research in question pointed to common strengths among successful leaders, like strategic thinking, adaptability and communication. To complete the test, you must answer around 150 questions, each within 20 seconds. Allen Cheung, a tech blogger, notes that CliftonStrengths is more valuable than your average career test because it includes “tricky questions which aren’t as easily gamed”.Red Bull WingfinderDeveloped and tested out by psychology experts, the Red Bull Wingfinder assesses your thinking under pressure. Questions include image sorting, logic puzzles and leadership-related questions. Once you complete the test, you’ll receive a nine-page report and career coaching tailored to your results.SEI Development ReportThe SEI Development Report is an extensive EQ aptitude test that has timed right-and-wrong answers that assess eight fundamentals, including emotional literacy, emotional management and empathy. At the end, you’ll receive a 20-page report with recommended courses on workplace EQ development.CareerOneStopWhile it only takes a few minutes to complete, the CareerOneStop Skills Assessment will help you rank both your technical and soft skills. The career suggestions at the end can be sorted by relevance, annual wages, and job outlook, coupled with with professional coaching orconsultation improve your skills.1.What do aptitude tests mainly assess for job seekers?A.Their work ethics.B.Their career interest.C.Their preferred work style.D.Their professional competence.2.What is a unique feature of Clifton Strengths?A.It evaluates leadership skills.B.It is developed by experts.C.It includes challenging questions.D.It offers a comprehensive report.3.Which test suits a job seeker who prefers categorized suggestions and career coaching?A.Clift on Strengths B.Red Bull WingfinderC.SEI Development Report D.CareerOneStop“Hey, lady! You can move your ugly car up now!” The silver-haired driver behind me in a fancy truck rudely yelled at me. Without much thought, I yelled back at the man, “What? Are you in a rush or something? ”I was waiting in line at the drive-through to order our breakfast on a Sunday morning. There were only 12 inches or so between me and the car in front of me. There were also three additional cars in front of that one. We were getting nowhere fast. What was he hoping to gain by yelling at me?I wanted to let my own anger go after this ridiculous exchange. But the more I thought about it, the angrier I got. I was angry that he yelled at a mother in front of two kids. My daughter and my son were both confused and saddened by what they had just witnessed. We were on our way to a soccer tournament, and we had a bonus day free from school and work. Probably, there was nothing in the world to be upset about. Then this man let his anger out.I told my kids I was so mad that I had to roll my window up so that I wouldn’t keep yelling at this guy. Then, I stopped and looked back. I had moved up the 12 or so inches at his “suggestion”, while he hadn’t moved an inch. Suddenly, I felt sympathy for him. He must have been suffering in some way. As my kids and I slowly made our way to the pick-up window to pay for our order, I had an idea.“I heard how rude that man was to you, and I wanted to apologize to you for having to put up with that. He isn’t worth paying for,” the cashier said to me. “My kids support me in doing that,”I answered the cashier, adding that hate cannot drive out hate.4.Why was the driver angry with the author?A.Her car cut in.B.She held up his truck.C.Her car stopped suddenly.D.She screamed at him.5.What does the author mainly tell us in paragraph 3?A.Why her anger kept growing.B.What her kids’ reaction was.C.How she calmed herself down D.Why she ordered the breakfast.6.What was the author’s final decision?A.She taught her kids a lesson.B.She apologized to the driver.C.She paid for the driver’s food.D.She gave the cashier some advice7.What does the author intend to convey in the text?A.Respond to hate with kindness B.Deal with a man as he deals with you.C.Put distance between your car and another.D.Never go to the drive-through at rush hoursIn October, Mediterranean fruit flies were discovered in an area of Los Angeles. California is a big farming state, and this was serious news for farmers. The solution to the problem may seem a little unusual: releasing millions more of the flies.The Mediterranean fruit fly, often known as the “Medfly”, is one of the most serious threats faced by farmers worldwide. Once the pest makes its way into an area, it can be very hard to get rid of. The flies lay their eggs in over 300 kinds of fruits and vegetables. When the eggs hatch, they turn into worm-like larvae (幼虫) that can ruin these products.Three Mediterranean fruit flies were discovered in a Los Angeles neighborhood called Leimert Park in October. To stop the problem from spreading, the government set up a large quarantine (隔离) area, which means that no produce (fruits, nuts, or vegetables) can be moved out of that area. That may seem extreme, since only three Medflies were found, but experts believe there are probably more out there. “It’s really important to get on top of this fast,” said entomologist Jason Leathers. Luckily, California has developed a program to control Medflies, and it’s been working well for 30 years. The plan involves using planes to drop millions of Medflies over the area. That may sound like a bad idea, but it’s actually a tricky way to make surethat Medfly numbers go down.The airplanes only drop male flies, and all of them have been treated so that they can’t help produce new fruit flies. The males are sterile (不育的). The plan has worked well in the past. The government says that the number of infestations (横行) has been cut by over 90%.8.What do we know about the “Medfly” from Paragraph 2?A.It ruins crops easily.B.It is the most harmful pest.C.Its produce rate is alarming.D.It troubles farmers all the world.9.What measure has been taken to control Medflies in California?A.Drop sterile Medflies.B.Seek scientists for advice.C.Employ planes to kill them.D.Set up large quarantine areas nationwide.10.What’s the author’s statement about the plan’s effectiveness based on?A.Statistics.B.Financial reports.C.Experts’ conclusion.D.Amounts of dropped flies.11.What’s the best title for the text?A.New Usage of Airplanes B.The Harm of the MedflyC.Fighting Fruit Flies with Fruit Flies D.Problems Facing Farms in CaliforniaWould you make the same decisions in a foreign language as you would in your native tongue? It may be intuitive that people would make the same choices regardless of the language they are using, or that the difficulty of using a foreign language would make decisions less systematic. We discovered, however, that the opposite is true: Using a foreign language reduces decision-making biases (偏差).Together with his students and collaborators, Professor Keysar has made discoveries about the impact of using a foreign language on choice, the way that language modality affects reasoning, how language affects health decisions and negotiations, and more. In a 2021study, Boaz Keysar, a professor at the University of Chicago in the US, led an experiment concerning how foreign languages relate to human ways of thinking.Whereas people were risk averse for gains and risk seeking for losses when choices werepresented in their native tongue, they were not influenced by this framing manipulation in a foreign language. People were asked to make a choice: Take a guarantee of one pound or take a 50 percent chance of winning 2.50 pounds. When presented with this choice in their native language, most people took the safe option of only getting one pound. But they were more willing to make the riskier choice when asked in a foreign language, leading to more profits overall, according to The Guardian. As Keysar put it, “People just hate the prospect (前景) of losing, but they hate it less in a foreign language. ”Keysar and his team did another experiment in which participants were given a series of related words like “dream”, “snooze”, “bed” and “rest”. Later, when asked which words they remembered hearing, people were more likely to mistakenly remember “sleep”, which was not on the list, in their native language. But it was much less likely to happen if they did the test in a foreign language.The evidence is clear: By learning a foreign language, you’re not just learning a language — you’re gaining a new state of mind.12.What aspect of the Boaz Keysar’s research in 2021 focus on?A.The impact of using a foreign language on choice.B.The way that language modality affects reasoning.C.How language affects health decisions and negotiations.D.The relationship between foreign languages and people’s way of thinking.13.What does the underlined word “averse” in Paragraph 3 refer to?A.willing B.slow C.opposed D.eager14.Why did Keysar and his team did the second experiment?A.To change people’s attitude to the game.B.To prove a foreign language influences the way of thinking.C.To show the choice is more correct when using a foreign language.D.To prove using a foreign language leads to memories with greater accuracy.15.Which of the following shows the development of ideas in the passage?I: Introduction P: Point C: ConclusionA.B.C.D.As a high school student, you’re likely used to learning through reading textbooks. 16 This lies at the heart of “experiential appreciation,” a philosophy that encourages you to engage directly with the world around you. It’s about learning from real-life experiences, and discovering a more profound and engaging way to learn.To practice experiential appreciation, you can start by getting involved in hands-on activities related to your subjects. They will provide a firsthand understanding of the concepts you’re studying, making learning active and meaningful. So, try joining a sports team, picking up a paintbrush, or taking part in a local charity event. 17As you dive deeper, immerse (沉浸) yourself fully in the surroundings and activities. When you’re in nature, don’t just look around. 18 Touching the leaves, feeling the wind and listening to the birds can enrich your learning and make each moment more memorable.19 After trying something new, ask yourself what you learned and how it made you feel. Write in a journal or discuss it with friends. This self-discovery turns experiences into life lessons and offers a deeper understanding of the world.Experiential appreciation transforms learning from a task to be completed into a journey to be treasured. 20 So, explore the world around you, let every experience shape you, and discover the endless possibilities that await. This is the core of true learning, where every moment is a step towards a richer, more enlightened life.A.It extends learning beyond textbooks.B.These activities bring learning to life.C.Mind the impact of your actions on the environment.D.Instead, activate your senses for a stronger tie with it.E.Take your experiences further by reflecting on them.F.Textbooks offer a systematic introduction to essential concepts and principles.G.Now consider expanding your learning from just reading to actively participating.二、完形填空Tobias, a 35-year-old Belgian musician, has become popular on social media for his excellent grasp of the Shanghai dialect. He has been sharing his everyday experiences, which he 21 in Shanghai dialect, on video-sharing and lifestyle 22 Douyin and Xiaohongshu, winning thousands of followers and millions of 23In the videos, he speaks 24 Shanghai dialect, which many non-locals believe is as difficult to learn and 25 as a foreign language. He talks about walking on the city’s streets, enjoying the food and music, and 26 his daily life in the city. Tobias started shooting and 27 these short videos for his own practice purposes. He didn’t expect so many people would be watching them, following him and sending him 28 and encouragement.Tobias did not bury his nose in textbooks or 29 intensive study to learn Shanghainese. He said his learning 30 involved getting immersed (沉浸) in a language environment, having a positive attitude, and speaking 31 “without being afraid to make mistakes” . He was not thinking too much when he started learning the Shanghai dialect — it was just for 32 .Tobias said he did not expect he would 33 the promotion of the Shanghai dialect, but it would be an 34 and pleasure if his posts encouraged his followers to learn and pass on the dialect. “I believe a dialect is the heart of a local 35 ” said the musician. 21.A.acts B.delivers C.competes D.votes 22.A.approaches B.habits C.platforms D.communities 23.A.likes B.dollars C.medals D.chances 24.A.ancient B.sweet C.modern D.fluent 25.A.understand B.write C.create D.practise 26.A.advancing B.searching C.recording D.observing 27.A.testing B.reviewing C.selling D.posting 28.A.notes B.comments C.reports D.replies 29.A.interrupt B.assess C.conduct D.appreciate 30.A.materials B.methods C.objectives D.resources31.A.secretly B.slowly C.happily D.bravely 32.A.fun B.work C.fame D.show 33.A.stick to B.contribute to C.focus on D.rely on 34.A.advantage B.opportunity C.honor D.option 35.A.authority B.history C.custom D.culture三、语法填空阅读下面短文,在空白处填入1个适当的单词或括号内单词的正确形式。
高三英语英语学习大数据分析单选题40题
高三英语英语学习大数据分析单选题40题1.In the era of big data, we need to analyze large amounts of information _____.A.thoroughlyB.approximatelyC.randomlyD.occasionally答案:A。
thoroughly 意为“彻底地、完全地”;approximately 意为“大约、近似地”;randomly 意为“随机地、任意地”;occasionally 意为“偶尔、间或”。
在大数据时代,我们需要彻底地分析大量信息,所以选A。
2.Big data can provide _____ insights into customer behavior.A.preciousB.valuableC.worthlessD.trivial答案:B。
precious 意为“珍贵的、宝贵的”,通常用于形容物品或情感;valuable 意为“有价值的”,可用于形容信息、建议等;worthless 意为“无价值的”;trivial 意为“琐碎的、不重要的”。
大数据能提供有价值的关于客户行为的见解,所以选B。
3.The analysis of big data requires powerful _____ tools.putationalB.manualC.primitiveD.ineffective答案:A。
computational 意为“计算的”;manual 意为“手工的”;primitive 意为“原始的”;ineffective 意为“无效的”。
大数据分析需要强大的计算工具,所以选A。
4.Big data analytics can help businesses make more _____ decisions.rmedB.uninformedC.randomD.hasty答案:A。
informed 意为“有根据的、明智的”;uninformed 意为“无知的、未被通知的”;random 意为“随机的”;hasty 意为“匆忙的”。
通用版2024高考英语二轮复习第一板块阅读理解之题型篇专题一第一讲细节理解题_定位信息巧比对讲义
专题一阅读理解[全国卷3年考情分析]题型与题量卷别细微环节理解题推理推断题主旨大意题词义揣测题考情分析从统计表可以看出,高考英语阅读理解的题型设置以细微环节理解题和推理推断题为主,兼顾主旨大意题和词义揣测题。
细微环节理解题相对简洁,而其他三种题型相对较难。
在近两年的考查趋向上,细微环节理解题的答案更加隐藏,叙述含蓄,干脆信息题会越来越少,取而代之的将是事实细微环节题加入很多推理、推断、归纳等元素;推理推断题的难度会适当加大。
本专题将对这四种题型进行递进式的指导。
2024 卷Ⅰ7 5 2 1 卷Ⅱ9 3 2 1 卷Ⅲ9 3 2 12024 卷Ⅰ7 6 1 1 卷Ⅱ 5 6 2 2 卷Ⅲ 6 6 2 12024 卷Ⅰ10 3 1 1卷Ⅱ7 5 1 2卷Ⅲ8 4 1 2第一讲细微环节理解题——定位信息巧比对细微环节理解题在英语高考阅读理解中占了较大的比重,而且此类题型相对比较简洁,只须要依据题干中的关键词,回到原文定位信息区间,稍加比对,就能得出正确答案。
因此,对于这类题目要力求读得快、找得准、答得对,力争不丢分,保住基本分才能得高分。
但有些细微环节理解题由于命题人有意设置障碍,把有用信息分散在文章不同位置,有时又有转折、否定等,因此有些题目须要细致地思索、对比、计算、对上下文关键信息把握和分析。
尽管细微环节理解题相对简洁,但不行掉以轻心。
细微环节理解题常见的考查题型有:干脆信息题、间接信息题、概括细微环节理解题和正误推断题。
一、题型特点要知晓(一)细微环节理解题常见设问方式1.特别疑问句形式。
以when, where, what, which, who, how much/many等疑问词引出的问题。
2.推断是非形式。
含有TRUE/FALSE, NOT true或EXCEPT等的推断是非的问题。
此时要留意题干中是否含有否定词,如not, never等。
3.以“According to ...”开头的提问形式。
学位英语2024试题及答案
学位英语2024试题及答案一、阅读理解(共40分)阅读下列短文,然后回答问题。
A.In recent years, the rapid development of technology has brought about significant changes in the way people work and live. The rise of remote work has allowed employees to work from anywhere, provided they have a stable internet connection. This has led to a shift in the traditional office environment, with many companies adopting flexible working arrangements.问题:1. What is the main idea of the passage? (5分)2. What benefits does remote work offer to employees? (5分)B.The concept of sustainable development has gained global attention. It emphasizes the need for economic growth that is environmentally friendly and socially inclusive. Governments and businesses are encouraged to adopt practices that reduce their environmental footprint while ensuring the well-being of communities.问题:1. What does sustainable development focus on? (5分)2. Who are the main actors in promoting sustainable development? (5分)二、完形填空(共20分)The world is facing a serious water shortage. It is estimated that by 2025, two-thirds of the world's population will be living in water-stressed conditions. This situation is particularly critical in regions where water resources are already scarce.[选择适当的单词或短语填入空白处]1. The situation is becoming more and more _______.(serious/critical)2. Scientists are _______ ways to improve water usage efficiency. (exploring/finding)3. Governments need to _______ the importance of water conservation. (emphasize/stress)三、翻译(共20分)将下列句子从中文翻译成英文。
医学英语往年试题及答案
医学英语往年试题及答案一、选择题(每题2分,共20分)1. The term "cardiology" refers to the study of which organ?A. HeartB. LungsC. LiverD. Kidneys2. Which of the following is not a type of diabetes?A. Type 1 diabetesB. Type 2 diabetesC. Gestational diabetesD. Type 4 diabetes3. The abbreviation "MRI" stands for:A. Magnetic Resonance ImagingB. Medical Research InstituteC. Multiple Risk IndicatorsD. Major Radiological Intervention4. In medical terms, "anemia" is a condition characterized by:A. High blood pressureB. Low blood sugarC. Low red blood cell count or low hemoglobinD. High cholesterol levels5. The term "pneumonia" is associated with an infection of which organ?A. HeartB. LungsC. StomachD. Brain6. Which of the following is a common symptom of the common cold?A. DiarrheaB. RashC. CoughD. Jaundice7. The medical abbreviation "OTC" stands for:A. Over the CounterB. Outpatient Treatment CenterC. Occupational Therapy CenterD. Oral Treatment Course8. A "biopsy" is a medical procedure to:A. Remove a sample of tissue for examinationB. Administer medicationC. Perform surgery to remove a tumorD. Examine the blood under a microscope9. The term "epidemic" refers to:A. A sudden increase in the number of cases of a diseaseB. A disease that is present in a communityC. A disease that is endemic to a particular areaD. A disease that has been eradicated10. The abbreviation "HIV" stands for:A. Human Immunodeficiency VirusB. Highly Infectious VirusC. Hepatitis Infection VirusD. Hemophiliac Immune Virus答案:1-5: A, D, A, C, B6-10: C, A, A, A, A二、填空题(每空1分,共10分)1. The medical term for inflammation of the lungs is__________.2. A __________ is a healthcare professional who specializes in the diagnosis and treatment of diseases and injuries of the musculoskeletal system.3. The abbreviation "AIDS" stands for Acquired Immune Deficiency __________.4. The process of medical imaging that uses X-rays to create images of the inside of the body is called __________.5. A __________ is a surgical procedure to remove a diseased or damaged organ or tissue.答案:1. Pneumonitis2. Orthopedist3. Syndrome4. Radiography5. Excision三、简答题(每题5分,共20分)1. What is the difference between a virus and a bacterium?2. Explain the concept of "herd immunity" in the context of public health.3. What is the role of white blood cells in the immune system?4. Describe the function of the thyroid gland.答案:1. A virus is a small infectious agent that can onlyreplicate inside the living cells of an organism, while a bacterium is a single-celled microorganism that can live independently and reproduce by binary fission.2. Herd immunity occurs when a large percentage of apopulation has become immune to an infection, therebyproviding a measure of protection for individuals who are not immune.3. White blood cells play a critical role in defending the body against both infectious disease and foreign invaders. They help to fight off infections by identifying, attacking, and eliminating pathogens.4. The thyroid gland is a butterfly-shaped gland located inthe neck that produces hormones which regulate the body's metabolism, growth, and development.四、翻译题(每题5分,共15分)1. 请将“慢性阻塞性肺病”翻译成英文。
高三英语科学前沿动态引人关注单选题30题及答案
高三英语科学前沿动态引人关注单选题30题及答案1.The new technology, known as AI, is changing our lives rapidly. Which of the following is NOT an application of AI?A.Face recognitionB.V oice assistantC.Manual laborD.Autonomous driving答案:C。
本题考查对人工智能(AI)应用的了解。
选项A“Face recognition”( 人脸识别)、选项B“V oice assistant”( 语音助手)和选项D“Autonomous driving”(自动驾驶)都是人工智能的常见应用。
而选项C“Manual labor” 体力劳动)并非人工智能的应用。
2.In the field of scientific research, quantum computing is considereda revolutionary technology. What is the main advantage of quantum computing over traditional computing?A.Higher speedB.Lower costC.Smaller sizeD.Easier operation答案:A。
本题考查量子计算的优势。
量子计算相比传统计算的主要优势是更高的速度。
选项B“Lower cost” 更低成本)、选项C“Smaller size”( 更小尺寸)和选项D“Easier operation”( 更容易操作)都不是量子计算的主要优势。
3.The development of 5G technology has brought many changes. Which of the following is NOT a feature of 5G?A.High speedB.Low latencyC.Narrow bandwidthD.Massive connectivity答案:C。
临床起始量的计算
Guidance for Industry and Reviewers Estimating the Safe Starting Dose in Clinical Trials for Therapeutics in Adult Healthy VolunteersDRAFT GUIDANCEThis guidance document is being distributed for comment purposes only. Comments and suggestions regarding this draft document should be submitted within 60 days of publication in the Federal Register of the notice announcing the availability of the draft guidance. Submit comments to Dockets Management Branch (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD 20852. All comments should be identified with the docket number listed in the notice of availability that publishes in the Federal Register.For questions regarding this draft document contact (CDER) Robert Osterberg, 301-594-5476 or (CBER) Martin Green 301-827-5349.U.S. Department of Health and Human ServicesFood and Drug AdministrationCenter for Drug Evaluation and Research (CDER)Center for Biologics Evaluation and Research (CBER)December 2002Pharmacology and ToxicologyGuidance for Industry and Reviewers Estimating the Safe Starting Dose in Clinical Trials for Therapeutics in Adult Healthy VolunteersAdditional copies are available from:Office of Training and CommunicationsDivision of Drug Information, HFD-240Center for Drug Evaluation and ResearchFood and Drug Administration5600 Fishers LaneRockville, MD 20857(Tel) 301-827-4573/cder/guidance/index.htmorOffice of Communication, Training andManufacturers Assistance (HFM-40)Center for Biologics Evaluation and ResearchFood and Drug Administration1401 Rockville PikeRockville, MD 20852-1448(Internet) /cber/guidelines.htmMail: The Voice Information System at 800-835-4709 or 301-827-1800U.S. Department of Health and Human ServicesFood and Drug AdministrationCenter for Drug Evaluation and Research (CDER)Center for Biologics Evaluation and Research (CBER)December 2002Pharmacology and ToxicologyTable of ContentsI.INTRODUCTION (1)II.SCOPE (1)III.OVERVIEW OF THE ALGORITHM (3)IV.STEP 1: NO OBSERVED ADVERSE EFFECT LEVEL (NOAEL)DETERMINATION (4)V.STEP 2: HUMAN EQUIVALENT DOSE (HED) CALCULATION (5)A.Conversion Based on Body Surface Area (5)B.Basis for Using Mg/Kg Conversions (7)C.Other Exceptions to Mg/M2 Scaling Between Species (8)VI.STEP 3: MOST APPROPRIATE SPECIES SELECTION (8)VII.STEP 4: APPLICATION OF SAFETY FACTOR (9)A.Increasing the Safety Factor (10)B.Decreasing the Safety Factor (11)VIII.STEP 5: CONSIDERATION OF THE PHARMACOLOGICALLY ACTIVE DOSE (PAD) (11)IX.SUMMARY (12)REFERENCES (13)APPENDIX A (15)APPENDIX B (17)APPENDIX C (22)APPENDIX D (23)APPENDIX E (25)GLOSSARY (26)1Guidance for Industry and Reviewers 1234Estimating the Safe Starting Dose in Clinical Trials 5for Therapeutics in Adult Healthy Volunteers6789This draft guidance, when finalized, will represent the Food and Drug Administration's (FDA's) current 10thinking on this topic. It does not create or confer any rights for or on any person and does not operate to 11bind FDA or the public. An alternative approach may be used if such approach satisfies the requirements 12of the applicable statutes and regulations.13141516I.INTRODUCTION1718This guidance outlines a process (algorithm) and vocabulary for deriving the maximum19recommended starting dose (MRSD) for "first in human" clinical trials of new molecular entities 20in adult healthy volunteers and recommends a standardized process by which the MRSD can be 21selected. The purpose of this process is to ensure the safety of the human volunteers.2223The goals of this guidance are to (1) establish a consistent terminology for discussing the starting 24dose, (2) provide common conversion factors for deriving a human equivalent dose, and (3)25delineate a strategy for selecting the MRSD for adult healthy volunteers, regardless of the26projected clinical use. This process is diagrammed with a flow chart that presents the decisions 27and calculations used to generate the MRSD from animal data. 282930II.SCOPE3132The process identified in this document pertains to determining the MRSD for adult healthy 33subjects when beginning a clinical investigation of any new drug or biological therapeutic that 34has been studied in animals. This document is not pertinent to prophylactic vaccines or35endogenous proteins (i.e., recombinant clotting factors) used at physiologic concentrations. The 36process outlined in this document does not address dose escalation or maximum allowable doses 37in clinical trials.38391This guidance has been prepared by the Office of New Drugs in the Center for Drug Evaluation and Research (CDER) in cooperation with the Center for Biologics Evaluation and Research (CBER) at the Food and Drug Administration.Although the process outlined in this document uses observed toxicities, administered doses, and 4041an algorithmic approach to calculate the MRSD, an alternative approach could be proposed that 42places primary emphasis on animal pharmacokinetics and modeling rather than dose. In a43limited number of cases, animal pharmacokinetic data may be useful in determining initial44clinical doses.2 However, in the majority of new INDs, animal data are not available in45sufficient detail to construct a scientifically valid, pharmacokinetic model whose aim is to46accurately project an MRSD.4748Toxicity should be avoided at the initial dose. However, doses should be chosen that allowreasonably rapid attainment of the phase 1 trial objectives (e.g., assessment of the therapeutic's 4950tolerability, pharmacodynamic or pharmacokinetic profile). All of the relevant preclinical data, 51including information on the pharmacologically active dose, the full toxicologic profile of the 52compound, and the pharmacokinetics (absorption, distribution, metabolism, and excretion) of the 53therapeutic, should be considered when determining the MRSD. Starting with doses lower than 54the MRSD is always a possible option and may be particularly appropriate to meet some clinical trial objectives.555657The remainder of this document will focus on the recommended algorithmic process for starting 58dose extrapolation from animals to humans based on administered doses, since this method will 59likely be useful for the majority of new INDs seeking to investigate new drugs in healthyvolunteers. Some classes of drugs (e.g., many cytotoxic or biological agents) are commonly6061introduced into initial clinical trials in patient volunteers rather than healthy volunteers.62Typically, this occurs when a drug is suspected or known to be unavoidably toxic. Although this 63document does not specifically address starting doses in patients, many principles and some64approaches recommended here may be applicable to designing such trials.2If the parent drug is measured in the plasma at multiple times and fits the range of toxic dose for two or moreanimal species, it may be possible to develop a pharmacokinetic model predicting human doses and concentrations and draw inferences about human safe plasma levels in the absence of prior human data. While quantitativemodeling for this purpose may be straightforward, the following points suggest this approach may present a number of difficulties when evaluating estimates of a safe starting dose. Generally, at the time of IND initiation, there are a number of unknowns regarding animal toxicity and comparability of human and animal pharmacokinetics andmetabolism: (1) human bioavailability and metabolism may differ significantly from that of animals; (2)mechanisms of toxicity may not be known (i.e., toxic accumulation in a peripheral compartment; and/or (3) toxicity may be due to an unidentified metabolite, not parent drug. Thus, to rely on pharmacokinetic models (based onparent drug in plasma) to gauge starting doses would require multiple untested assumptions. Modeling may be used with greatest validity to estimate human starting doses in special cases where few underlying assumptions would be necessary. Such cases are exemplified by large molecular weight proteins (like humanized monoclonal antibodies), which are intravenously administered, are removed from circulation by endocytosis rather than metabolizism, have immediate and detectable effects on blood cells, and have a volume of distribution limited to the plasma volume.Here, allometric, pharmacokinetic, and pharmacodynamic models have been useful in identifying the human mg/kg dose that would be predicted to correlate with safe drug plasma levels in nonhuman primates. Even in these cases, uncertainties (such as differences between human and chimpanzee receptor sensitivity or density) have been shown to affect human pharmacologic or toxicologic outcomes, and the use of safety factors as described in this document is still warranted.6566III.OVERVIEW OF THE ALGORITHM67The process for selecting the MRSD is presented in Figure 1 and described in this section. The 6869major elements C the determination of the no observed adverse effect levels (NOAELs) in the70tested species, conversion of NOAELs to human equivalent dose (HED), selection of the most 71appropriate species, and application of a safety factor C are all discussed in greater detail in72subsequent sections. Situations are also discussed in which the algorithm should be modified.73The algorithm is intended to be used for systemically administered therapeutics. Topical,intranasal, intra-tissue, and compartmental administration routes and depot formulations may7475have additional considerations, but similar principles should apply.76The process of calculating the MRSD should begin after the toxicity data have been analyzed. 7778Although only the NOAEL should be used directly in the algorithm for calculating a MRSD,79other data (exposure/toxicity relationships, pharmacologic data, or prior clinical experience withrelated drugs) can affect the choice of most appropriate species, scaling, and safety factors.808182The NOAEL for each species tested should be identified, then each should be converted to thehuman equivalent dose (HED) using appropriate scaling factors. For most systemically8384administered therapeutics, this conversion should be based on the normalization of doses to body85surface area. Although body surface area conversion is the usual way to approximate equivalentexposure if no further information is available, in some cases, extrapolating doses based on other 8687parameters may be more appropriate. This decision should be based on the data available for the88individual case. The body surface area normalization and the extrapolation of the animal dose to89human dose should be done in one step by dividing the NOAEL in each of the animal species90studied by the appropriate body surface area conversion factor (BSA-CF). This is a unitless91number that converts mg/kg dose for each animal species to the mg/kg dose in humans, which is92equivalent to the animal’s NOAEL on a mg/m2 basis. The resulting figure is called a human93equivalent dose (HED). The species that generates the lowest HED is called the most sensitive94species.95When information indicates that a particular species is most relevant for assessing human risk 9697(and deemed the most appropriate species), the HED for that species should be used in98subsequent calculations, regardless of whether this species was the most sensitive. This case iscommon for biologic therapies, many of which have high selectivity for binding to human target 99100proteins, and limited reactivity in species commonly used for toxicity testing. In such cases, in101vitro binding and activity studies should be done to select appropriate, relevant species beforetoxicity studies are designed (please refer to the ICH3 guidance for industry S6 Preclinical Safety 102103Evaluation of Biotechnology-Derived Pharmaceuticals for more details). Additionally, a species104might be considered an inappropriate toxicity model for a given drug if a dose-limiting toxicity105in that species was concluded to be of limited value for human risk assessment (based onhistorical comparisons of toxicities in species to those in humans across a therapeutic class). In 1063 International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals forHuman Use (ICH).this case, data from that species should not be used to derive the HED. Without any additional 107108information to guide the choice of the most appropriate species for assessing human risk, the109most sensitive species is designated the most appropriate, because using the lowest HED wouldgenerate the most conservative starting dose.110111112A safety factor should then be applied to the HED to increase assurance that the first dose inhumans will not cause adverse effects. The use of the safety factor should be based on the113114possibility that humans may be more sensitive to the toxic effects of a therapeutic agent than115predicted by the animal models, that bioavailability may vary across species, and that the modelstested do not evaluate all possible human toxicities. For example, ocular disturbances or pain 116117(such as severe headaches) in humans can be significant dose-limiting toxicities that may go118undetected in animal studies.119120In general, a safety factor of 10 is recommended. The MRSD should be obtained by dividing the121HED by the safety factor. Safety concerns or design shortcomings noted in animal studies may122increase the safety factor, and thus reduce the MRSD further. Alternatively, information about123the pharmacologic class (well-characterized classes of therapeutics with extensive human clinical124and preclinical experience) may allay concerns and form the basis of reducing the magnitude of125the default safety factor and increasing the MRSD. Although a dose lower than the MRSD can126be used as the actual starting dose, the process described here will derive the maximum127recommended starting dose. This algorithm generates a MRSD in units of mg/kg, a common128method of dosing used in phase 1 trials, but the equations and conversion factors provided in this129document (Table one, second column) can be used to generate final dosing units in the mg/m2 130form if desired.131132As previously stated, for purposes of initial clinical trials in adult healthy volunteers, the HED133should ordinarily be calculated from the animal NOAEL. If the HED is based on an alternative134index of effect, such as the pharmacologically active dose (PAD), this exception should be135prominently stipulated in descriptions of starting dose calculations.136137The remainder of this document provides a description of the individual steps in the138recommended process and the reasoning behind each step. The method is supported by a general139review and analysis by CDER and CBER examining the results from a number of therapeutics140entered into development.141142143IV.STEP 1: NO OBSERVED ADVERSE EFFECT LEVEL (NOAEL)DETERMINATION144145146The first step in determining the MRSD is to review and evaluate the available animal data sothat a NOAEL can be determined for each study. Several differing definitions of NOAEL exist, 147148but for selecting a starting dose, the following is used here: the highest dose level that does not149produce a significant increase in adverse effects. In this context, adverse effects that arestatistically significant and adverse effects that may be clinically significant (even if they are not 150151statistically significant) should be considered in the determination of the NOAEL. The NOAELis a generally accepted benchmark for safety when derived from appropriate animal studies and 152153can serve as the starting point for determining a reasonably safe starting dose of a new154therapeutic in healthy (or asymptomatic) human volunteers.155156The NOAEL is not the same as the no observed effect level (NOEL), which refers to any effect, 157not just adverse ones, although in some cases the two might be identical. The definition of the NOAEL, in contrast to that of the NOEL, reflects the view that some effects observed in the 158159animal may be acceptable pharmacodynamic actions of the therapeutic and may not raise a safety 160concern. The NOAEL should not be confused with lowest observed adverse effect level(LOAEL) or maximum tolerated dose (MTD). Both of the latter concepts are based on findings 161162of adverse effects and are not generally used as benchmarks for establishing safe starting doses in adult healthy volunteers. The term level refers to dose or dosage, generally expressed as163164mg/kg or mg/kg/day.165Initial IND submissions for first in human studies by definition lack human data or formal166167allometric comparison of pharmacokinetics. Measurements of systemic levels or exposure (i.e., 168AUC or Cmax) cannot be employed for setting a safe starting dose in humans, and it is critical to 169rely on dose and observed toxic response data from adequate and well-conducted toxicology 170studies. However, there are cases where data on bioavailability, metabolite profile, and plasma 171drug levels associated with toxicity may influence the choice of the NOAEL. One such case 172would be when saturation of drug absorption occurs at a dose that produces no toxicity. In this 173case, the lowest saturating dose, not the highest (non-toxic) dose, should be used for calculating 174the HED.175176There are essentially three types of findings in nonclinical toxicology studies that can be used to 177determine the NOAEL: (1) overt toxicity (e.g., clinical signs, macro- and microscopic lesions); 178(2) surrogate markers of toxicity (e.g., serum liver enzyme levels); and (3) exaggerated179pharmacodynamic effects. Although the nature and extent of adverse effects can vary greatlywith different types of therapeutics and it is anticipated that in many instances experts will180181disagree on the characterization of effects as being adverse or not, the use of NOAEL as a182benchmark for dose-setting in healthy volunteers should be acceptable to all responsibleinvestigators. As a general rule, an adverse effect observed in nonclinical toxicology studies 183184used to define a NOAEL for the purpose of dose-setting should be based on an effect that would be unacceptable if produced by the initial dose of a therapeutic in a phase 1 clinical trial185186conducted in adult healthy volunteers.187188189V.STEP 2: HUMAN EQUIVALENT DOSE (HED) CALCULATION190191A.Conversion Based on Body Surface Area192193After the NOAELs in the relevant animal studies have been determined, they are converted to 194human equivalent doses (HEDs). A decision should be made regarding the most appropriate 195method for extrapolating the animal dose to the equivalent human dose. Toxic endpoints fortherapeutics administered systemically to animals, such as the MTD or NOAEL, are usually 196assumed to scale well between species when doses are normalized to body surface area (i.e .,197mg/m 2). The basis for this assumption lies primarily with the work of Freireich et al. (1996) and 198Schein et al. (1970). These investigators reported that, for antineoplastic drugs, doses lethal to 19910 percent of rodents (LD 10s) and MTDs in non-rodents both correlated with the human MTD 200when the doses were normalized to the same administration schedule and expressed as mg/m 2.201Despite the subsequent analyses showing that the MTDs for this set of drugs scale best between 202species when doses are normalized to W 0.75 rather than W 0.67 (inherent in body surface area 203normalization), normalization to body surface area has remained a widespread practice for 204estimating an HED based on an animal dose.205206An analysis of the impact of the allometric exponent on the conversion of an animal dose to the 207HED was conducted (see Appendix A). Based on this analysis and on the fact that correcting for 208body surface area increases clinical trial safety by resulting in a more conservative starting dose 209estimate, it was concluded that the approach of converting NOAEL doses to an HED based on 210body surface area correction factors (i.e ., W 0.67) should be maintained for selecting starting doses 211for initial studies in adult healthy volunteers. Nonetheless, use of a different dose normalization 212approach, such as directly equating the human dose to the NOAEL in mg/kg, may be appropriate 213in some circumstances. Deviations from the surface area approach should be justified. The basis 214for justifying direct mg/kg conversion and examples in which other normalization methods are 215appropriate are described in the following subsection.216217Although normalization to body surface area is an appropriate method for extrapolating doses 218between species, consistent factors for converting doses from mg/kg to mg/m 2 have not always 219been used. Given that body surface area normalization provides a reasonable approach for 220estimating an HED, the factors used for converting doses from each species should be 221standardized. Since surface area varies with W 0.67, the conversion factors are therefore222dependent on the weight of the animals in the studies. However, analyses conducted to address 223the effect of body weight on the actual BSA-CF (body surface area - conversion factor)224demonstrated that a standard factor provides a reasonable estimate of the HED over a broad 225range of human and animal weights (see Appendix B). The conversion factors and divisors 226shown in Table 1, below, are therefore recommended as the standard values to be used for 227interspecies dose conversions for NOAELs in CDER and CBER. These factors may also be 228applied when comparing safety margins for other toxicity endpoints (e.g., reproductive toxicity 229and carcinogenicity) when other data for comparison, (i.e ., AUCs) are unavailable or are 230otherwise inappropriate for comparison.231232233Table 1: Conversion of Animal Doses to Human Equivalent Doses(HED) Based on Body Surface AreaTo convert animal dose in mg/kg to HED a in mg/kg, either:SpeciesTo convert animal dose in mg/kg to dose in mg/m²,multiply by km below:Divide animal dose by:Multiply Animal dose by:Human37------Child (20 kg)b 25------Mouse 312.30.08Hamster 57.40.13Rat 6 6.20.16Ferret7 5.30.19Guinea pig 8 4.60.22Rabbit 12 3.10.32Dog20 1.80.54Primates:Monkeys c 12 3.10.32Marmoset6 6.20.16Squirrel monkey7 5.30.19Baboon 20 1.80.54Micro-pig 27 1.40.73Mini-pig351.10.95aAssumes 60 kg human. For species not listed or for weights outside the standard ranges, human 234equivalent dose can be calculated from the formula:235HED = animal dose in mg/kg x (animal weight in kg/human weight in kg)0.33.236bThis km is provided for reference only since healthy children will rarely be volunteers for phase 1 trials.237cFor example, cynomolgus, rhesus, stumptail.238239 B.Basis for Using Mg/Kg Conversions240241The factors in Table 1 for scaling animal NOAEL to HEDs are based on the assumption that 242doses scale 1:1 between species when normalized to body surface area. However, there are 243occasions for which scaling based on body weight (i.e., setting the HED (mg/kg) = NOAEL 244(mg/kg)) may be more appropriate. To consider mg/kg scaling for a therapeutic, the available 245data should show that the NOAEL occurs at a similar mg/kg dose across species. The factors 246below should be satisfied before extrapolating to the HED on a mg/kg basis rather than using the 247mg/m 2 approach. Note that mg/kg scaling will give a 12-, 6-, and 2- fold higher HED than the 248default mg/m 2 approach for mice, rats, and dogs, respectively. If these factors cannot be met, the 249mg/m 2 scaling approach for determining the HED should be followed as it will lead to a safer 250MRSD.251252 1.NOAELs occur at a similar mg/kg dose across test species (for the studies with a 253given dosing regimen relevant to the proposed initial clinical trial).254255 2.If only two NOAELs from toxicology studies in separate species are available,256one of the following criteria should also be true:257258• The therapeutic is administered orally and the dose is limited by local259toxicities. Gastrointestinal (GI) compartment weight scales by W 0.94 . GI260volume determines the concentration of the therapeutic in the GI tract. It is 261262thus reasonable that the toxicity of the therapeutic would scale by mg/kg263(W1.0).264265•The toxicity in humans (for a particular class) is dependent on an exposure 266parameter that is highly correlated across species with dose on a mg/kg basis. 267For example, complement activation by systemically administered antisense 268oligonucleotides in humans is believed to be dependent upon Cmax (Geary et 269al., 1997). For some antisense drugs, the Cmax correlates across nonclinical 270species with mg/kg dose and in such instances mg/kg scaling would be271justified.272273•Other pharmacologic and toxicologic endpoints also scale between species by 274mg/kg for the therapeutic. Examples of such endpoints include the MTD,lowest lethal dose, and the pharmacologically active dose.275276277C.Other Exceptions to Mg/M2 Scaling Between Species2782791.Therapeutics administered by alternative routes (e.g., topical, intranasal,280subcutaneous, intramuscular) for which the dose is limited by local toxicities. 281Such therapeutics should be normalized to concentration (mg/area of application, 282for instance) or amount of drug (mg) at the application site.2832.Therapeutics administered into anatomical compartments that have little284subsequent distribution outside of the compartment. Examples are intrathecal, 285intravesical, intraocular, intrapleural, and intraperitoneal administration. Such 286therapeutics should be normalized between species according to the287compartmental volumes and concentrations of the therapeutic.2883.Biological products administered intravascularly with M r > 100,000 daltons. Such 289therapeutics should be normalized to mg/kg.290291292VI.STEP 3: MOST APPROPRIATE SPECIES SELECTION293294After the HEDs have been determined from the NOAELs from all toxicology studies relevant to 295the proposed human trial, the next step is to pick one HED for subsequent derivation of theMRSD. This HED should be chosen from the most appropriate species. In the absence of data 296297on species relevance, a default position is that the most appropriate species for deriving the298MRSD for a trial in adult healthy volunteers is the most sensitive species (i.e., the species in 299which the lowest HED can be identified).300301Factors that could influence the choice of the most appropriate species rather than the default to 302the most sensitive species include: (1) differences in the absorption, distribution, metabolism and 303elimination (ADME) of the therapeutic between the species; (2)class experience that may304indicate a particular model is predictive of human toxicity; or (3) limited biological cross-species pharmacologic reactivity of the therapeutic. This latter point is especially important for305。
初中趣味英语基础知识抢答100题
初中趣味英语基础知识抢答100题1. What is the capital of Australia?The capital of Australia is Canberra.2. Who wrote the famous play, Romeo and Juliet? Romeo and Juliet was written by William Shakespeare.3. How many planets are there in our solar system? There are eight planets in our solar system.4. What is the largest ocean in the world?The Pacific Ocean is the largest ocean in the world.5. Who painted the Mona Lisa?The Mona Lisa was painted by Leonardo da Vinci.6. What is the chemical symbol for gold?The chemical symbol for gold is Au.7. What is the largest organ in the human body?The skin is the largest organ in the human body.8. Who is the author of the Harry Potter series?J.K. Rowling is the author of the Harry Potter series. 9. What is the tallest mountain in the world?Mount Everest is the tallest mountain in the world.10. Which country is known as the land of the rising sun? Japan is known as the land of the rising sun.11. Who invented the telephone?Alexander Graham Bell invented the telephone.12. What is the largest desert in the world?The Sahara Desert is the largest desert in the world. 13. What is the chemical symbol for oxygen?The chemical symbol for oxygen is O.14. Who was the first person to walk on the moon?Neil Armstrong was the first person to walk on the moon.15. What is the longest river in the world?The Nile River is the longest river in the world.16. What is the national bird of the United States?The national bird of the United States is the Bald Eagle.17. Which country is famous for the Taj Mahal?India is famous for the Taj Mahal.18. Who wrote the famous novel, To Kill a Mockingbird?To Kill a Mockingbird was written by Harper Lee.19. What is the chemical symbol for water?The chemical symbol for water is H2O.20. Who painted the famous artwork, The Starry Night? The Starry Night was painted by Vincent van Gogh.21. What is the largest species of penguin?The Emperor Penguin is the largest species of penguin.22. Who was the first president of the United States?George Washington was the first president of the United States.23. What is the longest bone in the human body?The femur is the longest bone in the human body.24. Who wrote the famous novel, Pride and Prejudice?Pride and Prejudice was written by Jane Austen.25. What is the chemical symbol for carbon?The chemical symbol for carbon is C.26. Who is the famous scientist who proposed the theory of relativity?Albert Einstein proposed the theory of relativity.27. What is the largest continent in the world?Asia is the largest continent in the world.28. Who painted the famous artwork, The Last Supper? The Last Supper was painted by Leonardo da Vinci. 29. What is the national flower of Japan?The national flower of Japan is the cherry blossom.30. Who invented the lightbulb?Thomas Edison invented the lightbulb.31. What is the largest mammal in the world?The blue whale is the largest mammal in the world.32. Who wrote the famous novel, The Great Gatsby? The Great Gatsby was written by F. Scott Fitzgerald.33. What is the chemical symbol for iron?The chemical symbol for iron is Fe.34. Who is the famous scientist who developed the theory of evolution?Charles Darwin developed the theory of evolution.35. What is the largest bird in the world?The ostrich is the largest bird in the world.36. Who painted the famous artwork, The Scream?The Scream was painted by Edvard Munch.37. What is the national flower of the United States?The national flower of the United States is the rose.38. Who invented the theory of gravity?Isaac Newton invented the theory of gravity.39. What is the largest waterfall in the world?Angel Falls is the largest waterfall in the world.40. Who wrote the famous novel, Moby-Dick?Moby-Dick was written by Herman Melville.41. What is the chemical symbol for hydrogen?The chemical symbol for hydrogen is H.42. Who is the famous scientist who discovered penicillin? Alexander Fleming discovered penicillin.43. What is the largest big cat in the world?The tiger is the largest big cat in the world.44. Who painted the famous artwork, Guernica?Guernica was painted by Pablo Picasso.45. What is the national flower of England?The national flower of England is the rose.46. Who invented the theory of general relativity?Albert Einstein invented the theory of general relativity.47. What is the largest fish in the world?The whale shark is the largest fish in the world.48. Who wrote the famous novel, 1984?1984 was written by George Orwell.49. What is the chemical symbol for silver?The chemical symbol for silver is Ag.50. Who is the famous scientist who developed the laws of motion?Isaac Newton developed the laws of motion.51. What is the largest reptile in the world?The saltwater crocodile is the largest reptile in the world.52. Who painted the famous artwork, The Persistence of Memory?The Persistence of Memory was painted by Salvador Dalí.53. What is the national flower of France?The national flower of France is the iris.54. Who invented the theory of quantum mechanics?Max Planck and Albert Einstein contributed to the development of the theory of quantum mechanics.55. What is the largest cat species in the world?The Siberian tiger is the largest cat species in the world.56. Who wrote the famous novel, The Catcher in the Rye?The Catcher in the Rye was written by J.D. Salinger.57. What is the chemical symbol for calcium?The chemical symbol for calcium is Ca.58. Who is the famous scientist who discovered the theory of relativity?Albert Einstein formulated the theory of relativity.59. What is the largest amphibian in the world?The Chinese giant salamander is the largest amphibian in the world.60. Who painted the famous artwork, The Birth of Venus?The Birth of Venus was painted by Sandro Botticelli.61. What is the national flower of China?The national flower of China is the peony.62. Who invented the theory of special relativity?Albert Einstein formulated the theory of special relativity.63. What is the largest land-dwelling arthropod in the world?The coconut crab is the largest land-dwelling arthropod in the world.64. Who wrote the famous novel, Animal Farm?Animal Farm was written by George Orwell.65. What is the chemical symbol for helium?The chemical symbol for helium is He.66. Who is the famous scientist who discovered the lawsof motion?Sir Isaac Newton discovered the laws of motion.67. What is the largest butterfly species in the world?The Queen Alexandra's birdwing is the largest butterfly species in the world.68. Who painted the famous artwork, Girl with a Pearl Earring?Girl with a Pearl Earring was painted by Johannes Vermeer.69. What is the national flower of Germany?The national flower of Germany is the cornflower.70. Who invented the theory of general relativity?Albert Einstein developed the theory of general relativity.71. What is the largest living reptile in the world?The saltwater crocodile is the largest living reptile in the world.72. Who wrote the famous novel, The Lord of the Rings?The Lord of the Rings was written by J.R.R. Tolkien.73. What is the chemical symbol for sodium?The chemical symbol for sodium is Na.74. Who is the famous scientist who developed the theory of evolution by natural selection?Charles Darwin is the famous scientist who developed the theory of evolution by natural selection.75. What is the largest bird of prey in the world?The Andean condor is the largest bird of prey in the world.76. Who painted the famous artwork, The Night Watch?The Night Watch was painted by Rembrandt.77. What is the national flower of Italy?The national flower of Italy is the lily.78. Who invented the theory of quantum mechanics?Max Planck and Albert Einstein played key roles in the development of the theory of quantum mechanics.79. What is the largest species of bear in the world?The polar bear is the largest species of bear in the world.80. Who wrote the famous novel, The Hobbit?The Hobbit was written by J.R.R. Tolkien.81. What is the chemical symbol for potassium?The chemical symbol for potassium is K.82. Who is the famous scientist who discovered the concept of gravity?Sir Isaac Newton discovered the concept of gravity.83. What is the largest land animal in the world?The African elephant is the largest land animal in the world.84. Who painted the famous artwork, The Creation of Adam?The Creation of Adam was painted by Michelangelo.85. What is the national flower of Russia?The national flower of Russia is the chamomile.86. Who invented the theory of special relativity?Albert Einstein formulated the theory of special relativity.87. What is the largest snake species in the world?The reticulated python is the largest snake species in the world.88. Who wrote the famous novel, The Chronicles of Narnia?The Chronicles of Narnia was written by C.S. Lewis.89. What is the chemical symbol for nitrogen?The chemical symbol for nitrogen is N.90. Who is the famous scientist who discovered the laws of motion and gravity?Sir Isaac Newton discovered the laws of motion and gravity.91. What is the largest rodent in the world?The capybara is the largest rodent in the world.92. Who painted the famous artwork, The Starry Night Over the Rhône?The Starry Night Over the Rhône was painted by Vincent van Gogh.93. What is the national flower of Spain?The national flower of Spain is the carnation.94. Who invented the theory of relativity?Albert Einstein is credited with formulating the theory of relativity.95. What is the largest land-dwelling arachnid in the world?The Goliath birdeater spider is the largest land-dwelling arachnid in the world.96. Who wrote the famous novel, War and Peace?War and Peace was written by Leo Tolstoy.97. What is the chemical symbol for phosphorus?The chemical symbol for phosphorus is P.98. Who is the famous scientist who proposed the laws of motion?Sir Isaac Newton proposed the laws of motion.99. What is the largest fish species in the world?The whale shark is the largest fish species in the world.100. Who painted the famous artwork, The Creation of the Sun, Moon and Planets?The Creation of the Sun, Moon and Planets was painted by Michelangelo.。
小学上册G卷英语第1单元真题试卷[有答案]
小学上册英语第1单元真题试卷[有答案]英语试题一、综合题(本题有50小题,每小题1分,共100分.每小题不选、错误,均不给分)1 The ________ is a famous structure built in Paris.2 The ______ (小鸡) hatched from an egg yesterday.3 I enjoy ________ (做手工艺品).4 We have a ______ (快乐的) time during special celebrations.5 I enjoy going on field ______ (旅行) with my classmates. It’s a chance to learn outside the classroom.6 A _______ is a substance that can neutralize acids. (碱)7 What do we call a large natural stream of water?A. RiverB. CreekC. StreamD. Brook答案: A. River8 The _______ (World Health Organization) focuses on global health issues.9 This is my . (这是我的。
)10 The process of hydrolysis involves breaking down compounds using __________.11 The _____ can be seen in the sky as a streak of light.12 What do we call the circle around the Earth that is equally distant from the poles?A. EquatorB. TropicC. MeridianD. Latitude答案:A13 The owl hunts _______ (夜间) for food.14 What is the capital of France?A. LondonB. ParisC. RomeD. Berlin15 What do we call the protective covering of an egg?A. ShellB. YolkC. AlbumenD. Membrane16 My family enjoys cooking together ____.17 I want to make a ________ out of leaves.18 What do you call the shape of a football?A. SphereB. CylinderC. OvalD. Cube答案:C19 What is the temperature of ice?A. 0 degrees CelsiusB. 32 degrees FahrenheitC. Both A and BD. 100 degrees Celsius答案:C20 The _______ (Trail of Tears) was a forced relocation of Native Americans.21 Light travels faster than ______ (sound).22 The lake is very ___ (calm).23 The body system that helps us breathe is the ______ system.24 The _____ (fish/bird) is swimming.25 What do we call the study of how living things interact with each other and their environment?A. BiologyB. EcologyC. ChemistryD. Physics26 My brother is really into _______ (运动). 他希望能 _______ (动词).27 The body part that helps us breathe is called the ______.28 The color of bromothymol blue changes in acidic and basic solutions, indicating ______.29 The _____ (毒蛇) has bright colors to warn predators.30 The __________ (维京人) explored parts of Europe and North America.31 I love watching ______ (动画片) on weekends. They always make me smile.32 The chemical symbol for gold is _______.33 George Washington was the commander of the Continental ________.34 What do you call the person who helps you learn in school?A. DoctorB. TeacherC. CookD. Driver35 The boiling point of a liquid is affected by _____.36 What do you call a person who participates in a sport?A. AthleteB. PlayerC. CompetitorD. All of the above答案:D37 A skunk has a unique way to ________________ (防御).38 The cave-dwelling bat uses ________________ (回声定位) to navigate.39 Auroras occur near the ______ poles.40 A ______ (园丁) enjoys working with soil.41 I learned to call my neighbors ______ because it shows kindness. (我学会了称呼我的邻居为,因为这显示了友善。
2024全国高考真题英语汇编:阅读理解D篇
2024全国高考真题英语汇编阅读理解D篇一、阅读理解(2024·浙江·高考真题)The Stanford marshmallow (棉花糖) test was originally conducted by psychologist Walter Mischel in the late 1960s. Children aged four to six at a nursery school were placed in a room. A single sugary treat, selected by the child, was placed on a table. Each child was told if they waited for 15 minutes before eating the treat, they would be given a second treat. Then they were left alone in the room. Follow-up studies with the children later in life showed a connection between an ability to wait long enough to obtain a second treat and various forms of success.As adults we face a version of the marshmallow test every day. We’re not tempted by sugary treats, but by our computers, phones, and tablets — all the devices that connect us to the global delivery system for various types of information that do to us what marshmallows do to preschoolers.We are tempted by sugary treats because our ancestors lived in a calorie-poor world, and our brains developed a response mechanism to these treats that reflected their value — a feeling of reward and satisfaction. But as we’ve reshaped the world around us, dramatically reducing the cost and effort involved in obtaining calories, we still have the same brains we had thousands of years ago, and this mismatch is at the heart of why so many of us struggle to resist tempting foods that we know we shouldn’t eat.A similar process is at work in our response to information. Our formative environment as a species was information-poor, so our brains developed a mechanism that prized new information. But global connectivity has greatly changed our information environment. We are now ceaselessly bombarded (轰炸) with new information. Therefore, just as we need to be more thoughtful about our caloric consumption, we also need to be more thoughtful about our information consumption, resisting the temptation of the mental “junk food” in order to manage our time most effectively.1.What did the children need to do to get a second treat in Mischel’s test?A.Take an examination alone.B.Share their treats with others.C.Delay eating for fifteen minutes.D.Show respect for the researchers.2.According to Paragraph 3, there is a mismatch between_______.A.the calorie-poor world and our good appetites B.the shortage of sugar and our nutritional needsC.the tempting foods and our efforts to keep fit D.the rich food supply and our unchanged brains 3.What does the author suggest readers do?A.Be selective information consumers.B.Absorb new information readily.C.Use diverse information sources.D.Protect the information environment.4.Which of the following is the best title for the text?A.Eat Less, Read More B.The Later, the BetterC.The Marshmallow Test for Grownups D.The Bitter Truth about Early Humans(2024·全国·高考真题)In the race to document the species on Earth before they go extinct, researchers and citizen scientists have collected billions of records. Today, most records of biodiversity are often in the form of photos, videos, and other digital records. Though they are useful for detecting shifts in the number and variety of species inan area, a new Stanford study has found that this type of record is not perfect.“With the rise of technology it is easy for people to make observations of different species with the aid of a mobile application,” said Barnabas Daru, who is lead author of the study and assistant professor of biology in the Stanford School of Humanities and Sciences. “These observations now outnumber the primary data that comes from physical specimens (标本), and since we are increasingly using observational data to investigate how species are responding to global change, I wanted to know: Are they usable?”Using a global dataset of 1.9 billion records of plants, insects, birds, and animals, Daru and his team tested how well these data represent actual global biodiversity patterns.“We were particularly interested in exploring the aspects of sampling that tend to bias (使有偏差) data, like the greater likelihood of a citizen scientist to take a picture of a flowering plant instead of the grass right next to it,” said Daru.Their study revealed that the large number of observation-only records did not lead to better global coverage. Moreover, these data are biased and favor certain regions, time periods, and species. This makes sense because the people who get observational biodiversity data on mobile devices are often citizen scientists recording their encounters with species in areas nearby. These data are also biased toward certain species with attractive or eye-catching features.What can we do with the imperfect datasets of biodiversity?“Quite a lot,” Daru explained. “Biodiversity apps can use our study results to inform users of oversampled areas and lead them to places — and even species — that are not well-sampled. To improve the quality of observational data, biodiversity apps can also encourage users to have an expert confirm the identification of their uploaded image.”5.What do we know about the records of species collected now?A.They are becoming outdated.B.They are mostly in electronic form.C.They are limited in number.D.They are used for public exhibition.6.What does Daru’s study focus on?A.Threatened species.B.Physical specimens.C.Observational data.D.Mobile applications.7.What has led to the biases according to the study?A.Mistakes in data analysis.B.Poor quality of uploaded pictures.C.Improper way of sampling.D.Unreliable data collection devices.8.What is Daru’s suggestion for biodiversity apps?A.Review data from certain areas.B.Hire experts to check the records.C.Confirm the identity of the users.D.Give guidance to citizen scientists.(2024·全国·高考真题)Given the astonishing potential of AI to transform our lives, we all need to take action to deal with our AI-powered future, and this is where AI by Design: A Plan for Living with Artificial Intelligence comes in. This absorbing new book by Catriona Campbell is a practical roadmap addressing the challenges posed by the forthcoming AI revolution (变革).In the wrong hands, such a book could prove as complicated to process as the computer code (代码) thatpowers AI but, thankfully, Campbell has more than two decades’ professional experience translating the heady into the understandable. She writes from the practical angle of a business person rather than as an academic, making for a guide which is highly accessible and informative and which, by the close, will make you feel almost as smart as AI.As we soon come to learn from AI by Design, AI is already super-smart and will become more capable, moving from the current generation of “narrow-AI” to Artificial General Intelligence. From there, Campbell says, will come Artificial Dominant Intelligence. This is why Campbell has set out to raise awareness of AI and its future now — several decades before these developments are expected to take place. She says it is essential that we keep control of artificial intelligence, or risk being sidelined and perhaps even worse.Campbell’s point is to wake up those responsible for AI-the technology companies and world leaders—so they are on the same page as all the experts currently developing it. She explains we are at a “tipping point” in history and must act now to prevent an extinction-level event for humanity. We need to consider how we want our future with AI to pan out. Such structured thinking, followed by global regulation, will enable us to achieve greatness rather than our downfall.AI will affect us all, and if you only read one book on the subject, this is it.9.What does the phrase “In the wrong hands” in paragraph 2 probably mean?A.If read by someone poorly educated.B.If reviewed by someone ill-intentioned.C.If written by someone less competent.D.If translated by someone unacademic.10.What is a feature of AI by Design according to the text?A.It is packed with complex codes.B.It adopts a down-to-earth writing style.C.It provides step-by-step instructions.D.It is intended for AI professionals.11.What does Campbell urge people to do regarding AI development?A.Observe existing regulations on it.B.Reconsider expert opinions about it.C.Make joint efforts to keep it under control.D.Learn from prior experience to slow it down.12.What is the author’s purpose in writing the text?A.To recommend a book on AI.B.To give a brief account of AI history.C.To clarify the definition of AI.D.To honor an outstanding AI expert.(2024·全国·高考真题)“I didn’t like the ending,” I said to my favorite college professor. It was my junior year of undergraduate, and I was doing an independent study on Victorian literature. I had just finished reading The Mill on the Floss by George Eliot, and I was heartbroken with the ending. Prof. Gracie, with all his patience, asked me to think about it beyond whether I liked it or not. He suggested I think about the difference between endings that I wanted for the characters and endings that were right for the characters, endings that satisfied the story even if they didn’t have a traditionally positive outcome. Of course, I would have preferred a different ending for Tom and Maggie Tulliver, but the ending they got did make the most sense for them.This was an aha moment for me, and I never thought about endings the same way again. From then on, if I wanted to read an ending guaranteed to be happy, I’d pick up a love romance. If I wanted an ending I couldn’t guess, I’d pick up a mystery (悬疑小说). One where I kind of knew what was going to happen, historical fiction. Choosingwhat to read became easier.But writing the end — that’s hard. It’s hard for writers because endings carry so much weight with readers. You have to balance creating an ending that's unpredictable, but doesn’t seem to come from nowhere, one that fits what’s right for the characters.That’s why this issue (期) of Writer’s Digest aims to help you figure out how to write the best ending for whatever kind of writing you’re doing. If it’s short stories, Peter Mountford breaks down six techniques you can try to see which one helps you stick the landing. Elizabeth Sims analyzes the final chapters of five great novels to see what key points they include and how you can adapt them for your work.This issue won’t tell you what your ending should be — that’s up to you and the story you’re telling — but it might provide what you need to get there.13.Why did the author go to Prof. Gracie?A.To discuss a novel.B.To submit a book report.C.To argue for a writer.D.To ask for a reading list.14.What did the author realize after seeing Gracie?A.Writing is a matter of personal preferences.B.Readers are often carried away by character.C.Each type of literature has its unique end.D.A story which begins well will end well.15.What is expected of a good ending?A.It satisfies readers’ taste.B.It fits with the story development.C.It is usually positive.D.It is open for imagination.16.Why does the author mention Peter Mountford and Elizabeth Sims?A.To give examples of great novelists.B.To stress the theme of this issue.C.To encourage writing for the magazine.D.To recommend their new books.(2024·北京·高考真题)Franz Boas’s description of Inuit (因纽特人) life in the 19th century illustrates the probable moral code of early humans. Here, norms (规范) were unwritten and rarely expressed clearly, but were well understood and taken to heart. Dishonest and violent behaviours were disapproved of; leadership, marriage and interactions with other groups were loosely governed by traditions. Conflict was often resolved in musical battles. Because arguing angrily leads to chaos, it was strongly discouraged. With life in the unforgiving Northern Canada being so demanding, the Inuit’s practical approach to morality made good sense.The similarity of moral virtues across cultures is striking, even though the relative ranking of the virtues may vary with a social group’s history and environment. Typically, cruelty and cheating are discouraged, while cooperation, humbleness and courage are praised. These universal norms far pre-date the concept of any moralising religion or written law. Instead, they are rooted in the similarity of basic human needs and our shared mechanisms for learning and problem solving. Our social instincts (本能) include the intense desire to belong. The approval of others is rewarding, while their disapproval is strongly disliked. These social emotions prepare our brains to shape our behaviour according to the norms and values of our family and our community. More generally, social instincts motivate us to learn how to behave in a socially complex world.The mechanism involves a repurposed reward system originally used to develop habits important for self-care. Our brains use the system to acquire behavioural patterns regarding safe routes home, efficient food gathering and dangers to avoid. Good habits save time, energy and sometimes your life. Good social habits do something similar in a social context. We learn to tell the truth, even when lying is self-serving; we help a grandparent even when it is inconvenient. We acquire what we call a sense of right and wrong.Social benefits are accompanied by social demands: we must get along, but not put up with too much. Hence self-discipline is advantageous. In humans, a greatly enlarged brain boosts self-control, just as it boosts problem-solving skills in the social as well as the physical world. These abilities are strengthened by our capacity for language, which allows social practices to develop in extremely unobvious ways.17.What can be inferred about the forming of the Inuit’s moral code?A.Living conditions were the drive.B.Unwritten rules were the target.C.Social tradition was the basis.D.Honesty was the key.18.What can we learn from this passage?A.Inconveniences are the cause of telling lies.B.Basic human needs lead to universal norms.C.Language capacity is limited by self-control.D.Written laws have great influence on virtues. 19.Which would be the best title for this passage?A.Virtues: Bridges Across Cultures B.The Values of Self-disciplineC.Brains: Walls Against Chaos D.The Roots of Morality参考答案1.C 2.D 3.A 4.C【导语】这是一篇说明文。
专八英语阅读
英语专业八级考试TEM-8阅读理解练习册(1)(英语专业2012级)UNIT 1Text AEvery minute of every day, what ecologist生态学家James Carlton calls a global ―conveyor belt‖, redistributes ocean organisms生物.It’s planetwide biological disruption生物的破坏that scientists have barely begun to understand.Dr. Carlton —an oceanographer at Williams College in Williamstown,Mass.—explains that, at any given moment, ―There are several thousand marine species traveling… in the ballast water of ships.‖ These creatures move from coastal waters where they fit into the local web of life to places where some of them could tear that web apart. This is the larger dimension of the infamous无耻的,邪恶的invasion of fish-destroying, pipe-clogging zebra mussels有斑马纹的贻贝.Such voracious贪婪的invaders at least make their presence known. What concerns Carlton and his fellow marine ecologists is the lack of knowledge about the hundreds of alien invaders that quietly enter coastal waters around the world every day. Many of them probably just die out. Some benignly亲切地,仁慈地—or even beneficially — join the local scene. But some will make trouble.In one sense, this is an old story. Organisms have ridden ships for centuries. They have clung to hulls and come along with cargo. What’s new is the scale and speed of the migrations made possible by the massive volume of ship-ballast water压载水— taken in to provide ship stability—continuously moving around the world…Ships load up with ballast water and its inhabitants in coastal waters of one port and dump the ballast in another port that may be thousands of kilometers away. A single load can run to hundreds of gallons. Some larger ships take on as much as 40 million gallons. The creatures that come along tend to be in their larva free-floating stage. When discharged排出in alien waters they can mature into crabs, jellyfish水母, slugs鼻涕虫,蛞蝓, and many other forms.Since the problem involves coastal species, simply banning ballast dumps in coastal waters would, in theory, solve it. Coastal organisms in ballast water that is flushed into midocean would not survive. Such a ban has worked for North American Inland Waterway. But it would be hard to enforce it worldwide. Heating ballast water or straining it should also halt the species spread. But before any such worldwide regulations were imposed, scientists would need a clearer view of what is going on.The continuous shuffling洗牌of marine organisms has changed the biology of the sea on a global scale. It can have devastating effects as in the case of the American comb jellyfish that recently invaded the Black Sea. It has destroyed that sea’s anchovy鳀鱼fishery by eating anchovy eggs. It may soon spread to western and northern European waters.The maritime nations that created the biological ―conveyor belt‖ should support a coordinated international effort to find out what is going on and what should be done about it. (456 words)1.According to Dr. Carlton, ocean organism‟s are_______.A.being moved to new environmentsB.destroying the planetC.succumbing to the zebra musselD.developing alien characteristics2.Oceanographers海洋学家are concerned because_________.A.their knowledge of this phenomenon is limitedB.they believe the oceans are dyingC.they fear an invasion from outer-spaceD.they have identified thousands of alien webs3.According to marine ecologists, transplanted marinespecies____________.A.may upset the ecosystems of coastal watersB.are all compatible with one anotherC.can only survive in their home watersD.sometimes disrupt shipping lanes4.The identified cause of the problem is_______.A.the rapidity with which larvae matureB. a common practice of the shipping industryC. a centuries old speciesD.the world wide movement of ocean currents5.The article suggests that a solution to the problem__________.A.is unlikely to be identifiedB.must precede further researchC.is hypothetically假设地,假想地easyD.will limit global shippingText BNew …Endangered‟ List Targets Many US RiversIt is hard to think of a major natural resource or pollution issue in North America today that does not affect rivers.Farm chemical runoff残渣, industrial waste, urban storm sewers, sewage treatment, mining, logging, grazing放牧,military bases, residential and business development, hydropower水力发电,loss of wetlands. The list goes on.Legislation like the Clean Water Act and Wild and Scenic Rivers Act have provided some protection, but threats continue.The Environmental Protection Agency (EPA) reported yesterday that an assessment of 642,000 miles of rivers and streams showed 34 percent in less than good condition. In a major study of the Clean Water Act, the Natural Resources Defense Council last fall reported that poison runoff impairs损害more than 125,000 miles of rivers.More recently, the NRDC and Izaak Walton League warned that pollution and loss of wetlands—made worse by last year’s flooding—is degrading恶化the Mississippi River ecosystem.On Tuesday, the conservation group保护组织American Rivers issued its annual list of 10 ―endangered‖ and 20 ―threatened‖ rivers in 32 states, the District of Colombia, and Canada.At the top of the list is the Clarks Fork of the Yellowstone River, whereCanadian mining firms plan to build a 74-acre英亩reservoir水库,蓄水池as part of a gold mine less than three miles from Yellowstone National Park. The reservoir would hold the runoff from the sulfuric acid 硫酸used to extract gold from crushed rock.―In the event this tailings pond failed, the impact to th e greater Yellowstone ecosystem would be cataclysmic大变动的,灾难性的and the damage irreversible不可逆转的.‖ Sen. Max Baucus of Montana, chairman of the Environment and Public Works Committee, wrote to Noranda Minerals Inc., an owner of the ― New World Mine‖.Last fall, an EPA official expressed concern about the mine and its potential impact, especially the plastic-lined storage reservoir. ― I am unaware of any studies evaluating how a tailings pond尾矿池,残渣池could be maintained to ensure its structural integrity forev er,‖ said Stephen Hoffman, chief of the EPA’s Mining Waste Section. ―It is my opinion that underwater disposal of tailings at New World may present a potentially significant threat to human health and the environment.‖The results of an environmental-impact statement, now being drafted by the Forest Service and Montana Department of State Lands, could determine the mine’s future…In its recent proposal to reauthorize the Clean Water Act, the Clinton administration noted ―dramatically improved water quality since 1972,‖ when the act was passed. But it also reported that 30 percent of riverscontinue to be degraded, mainly by silt泥沙and nutrients from farm and urban runoff, combined sewer overflows, and municipal sewage城市污水. Bottom sediments沉积物are contaminated污染in more than 1,000 waterways, the administration reported in releasing its proposal in January. Between 60 and 80 percent of riparian corridors (riverbank lands) have been degraded.As with endangered species and their habitats in forests and deserts, the complexity of ecosystems is seen in rivers and the effects of development----beyond the obvious threats of industrial pollution, municipal waste, and in-stream diversions改道to slake消除the thirst of new communities in dry regions like the Southwes t…While there are many political hurdles障碍ahead, reauthorization of the Clean Water Act this year holds promise for US rivers. Rep. Norm Mineta of California, who chairs the House Committee overseeing the bill, calls it ―probably the most important env ironmental legislation this Congress will enact.‖ (553 words)6.According to the passage, the Clean Water Act______.A.has been ineffectiveB.will definitely be renewedC.has never been evaluatedD.was enacted some 30 years ago7.“Endangered” rivers are _________.A.catalogued annuallyB.less polluted than ―threatened rivers‖C.caused by floodingD.adjacent to large cities8.The “cataclysmic” event referred to in paragraph eight would be__________.A. fortuitous偶然的,意外的B. adventitious外加的,偶然的C. catastrophicD. precarious不稳定的,危险的9. The owners of the New World Mine appear to be______.A. ecologically aware of the impact of miningB. determined to construct a safe tailings pondC. indifferent to the concerns voiced by the EPAD. willing to relocate operations10. The passage conveys the impression that_______.A. Canadians are disinterested in natural resourcesB. private and public environmental groups aboundC. river banks are erodingD. the majority of US rivers are in poor conditionText CA classic series of experiments to determine the effects ofoverpopulation on communities of rats was reported in February of 1962 in an article in Scientific American. The experiments were conducted by a psychologist, John B. Calhoun and his associates. In each of these experiments, an equal number of male and female adult rats were placed in an enclosure and given an adequate supply of food, water, and other necessities. The rat populations were allowed to increase. Calhoun knew from experience approximately how many rats could live in the enclosures without experiencing stress due to overcrowding. He allowed the population to increase to approximately twice this number. Then he stabilized the population by removing offspring that were not dependent on their mothers. He and his associates then carefully observed and recorded behavior in these overpopulated communities. At the end of their experiments, Calhoun and his associates were able to conclude that overcrowding causes a breakdown in the normal social relationships among rats, a kind of social disease. The rats in the experiments did not follow the same patterns of behavior as rats would in a community without overcrowding.The females in the rat population were the most seriously affected by the high population density: They showed deviant异常的maternal behavior; they did not behave as mother rats normally do. In fact, many of the pups幼兽,幼崽, as rat babies are called, died as a result of poor maternal care. For example, mothers sometimes abandoned their pups,and, without their mothers' care, the pups died. Under normal conditions, a mother rat would not leave her pups alone to die. However, the experiments verified that in overpopulated communities, mother rats do not behave normally. Their behavior may be considered pathologically 病理上,病理学地diseased.The dominant males in the rat population were the least affected by overpopulation. Each of these strong males claimed an area of the enclosure as his own. Therefore, these individuals did not experience the overcrowding in the same way as the other rats did. The fact that the dominant males had adequate space in which to live may explain why they were not as seriously affected by overpopulation as the other rats. However, dominant males did behave pathologically at times. Their antisocial behavior consisted of attacks on weaker male,female, and immature rats. This deviant behavior showed that even though the dominant males had enough living space, they too were affected by the general overcrowding in the enclosure.Non-dominant males in the experimental rat communities also exhibited deviant social behavior. Some withdrew completely; they moved very little and ate and drank at times when the other rats were sleeping in order to avoid contact with them. Other non-dominant males were hyperactive; they were much more active than is normal, chasing other rats and fighting each other. This segment of the rat population, likeall the other parts, was affected by the overpopulation.The behavior of the non-dominant males and of the other components of the rat population has parallels in human behavior. People in densely populated areas exhibit deviant behavior similar to that of the rats in Calhoun's experiments. In large urban areas such as New York City, London, Mexican City, and Cairo, there are abandoned children. There are cruel, powerful individuals, both men and women. There are also people who withdraw and people who become hyperactive. The quantity of other forms of social pathology such as murder, rape, and robbery also frequently occur in densely populated human communities. Is the principal cause of these disorders overpopulation? Calhoun’s experiments suggest that it might be. In any case, social scientists and city planners have been influenced by the results of this series of experiments.11. Paragraph l is organized according to__________.A. reasonsB. descriptionC. examplesD. definition12.Calhoun stabilized the rat population_________.A. when it was double the number that could live in the enclosure without stressB. by removing young ratsC. at a constant number of adult rats in the enclosureD. all of the above are correct13.W hich of the following inferences CANNOT be made from theinformation inPara. 1?A. Calhoun's experiment is still considered important today.B. Overpopulation causes pathological behavior in rat populations.C. Stress does not occur in rat communities unless there is overcrowding.D. Calhoun had experimented with rats before.14. Which of the following behavior didn‟t happen in this experiment?A. All the male rats exhibited pathological behavior.B. Mother rats abandoned their pups.C. Female rats showed deviant maternal behavior.D. Mother rats left their rat babies alone.15. The main idea of the paragraph three is that __________.A. dominant males had adequate living spaceB. dominant males were not as seriously affected by overcrowding as the otherratsC. dominant males attacked weaker ratsD. the strongest males are always able to adapt to bad conditionsText DThe first mention of slavery in the statutes法令,法规of the English colonies of North America does not occur until after 1660—some forty years after the importation of the first Black people. Lest we think that existed in fact before it did in law, Oscar and Mary Handlin assure us, that the status of B lack people down to the 1660’s was that of servants. A critique批判of the Handlins’ interpretation of why legal slavery did not appear until the 1660’s suggests that assumptions about the relation between slavery and racial prejudice should be reexamined, and that explanation for the different treatment of Black slaves in North and South America should be expanded.The Handlins explain the appearance of legal slavery by arguing that, during the 1660’s, the position of white servants was improving relative to that of black servants. Thus, the Handlins contend, Black and White servants, heretofore treated alike, each attained a different status. There are, however, important objections to this argument. First, the Handlins cannot adequately demonstrate that t he White servant’s position was improving, during and after the 1660’s; several acts of the Maryland and Virginia legislatures indicate otherwise. Another flaw in the Handlins’ interpretation is their assumption that prior to the establishment of legal slavery there was no discrimination against Black people. It is true that before the 1660’s Black people were rarely called slaves. But this shouldnot overshadow evidence from the 1630’s on that points to racial discrimination without using the term slavery. Such discrimination sometimes stopped short of lifetime servitude or inherited status—the two attributes of true slavery—yet in other cases it included both. The Handlins’ argument excludes the real possibility that Black people in the English colonies were never treated as the equals of White people.The possibility has important ramifications后果,影响.If from the outset Black people were discriminated against, then legal slavery should be viewed as a reflection and an extension of racial prejudice rather than, as many historians including the Handlins have argued, the cause of prejudice. In addition, the existence of discrimination before the advent of legal slavery offers a further explanation for the harsher treatment of Black slaves in North than in South America. Freyre and Tannenbaum have rightly argued that the lack of certain traditions in North America—such as a Roman conception of slavery and a Roman Catholic emphasis on equality— explains why the treatment of Black slaves was more severe there than in the Spanish and Portuguese colonies of South America. But this cannot be the whole explanation since it is merely negative, based only on a lack of something. A more compelling令人信服的explanation is that the early and sometimes extreme racial discrimination in the English colonies helped determine the particular nature of the slavery that followed. (462 words)16. Which of the following is the most logical inference to be drawn from the passage about the effects of “several acts of the Maryland and Virginia legislatures” (Para.2) passed during and after the 1660‟s?A. The acts negatively affected the pre-1660’s position of Black as wellas of White servants.B. The acts had the effect of impairing rather than improving theposition of White servants relative to what it had been before the 1660’s.C. The acts had a different effect on the position of white servants thandid many of the acts passed during this time by the legislatures of other colonies.D. The acts, at the very least, caused the position of White servants toremain no better than it had been before the 1660’s.17. With which of the following statements regarding the status ofBlack people in the English colonies of North America before the 1660‟s would the author be LEAST likely to agree?A. Although black people were not legally considered to be slaves,they were often called slaves.B. Although subject to some discrimination, black people had a higherlegal status than they did after the 1660’s.C. Although sometimes subject to lifetime servitude, black peoplewere not legally considered to be slaves.D. Although often not treated the same as White people, black people,like many white people, possessed the legal status of servants.18. According to the passage, the Handlins have argued which of thefollowing about the relationship between racial prejudice and the institution of legal slavery in the English colonies of North America?A. Racial prejudice and the institution of slavery arose simultaneously.B. Racial prejudice most often the form of the imposition of inheritedstatus, one of the attributes of slavery.C. The source of racial prejudice was the institution of slavery.D. Because of the influence of the Roman Catholic Church, racialprejudice sometimes did not result in slavery.19. The passage suggests that the existence of a Roman conception ofslavery in Spanish and Portuguese colonies had the effect of _________.A. extending rather than causing racial prejudice in these coloniesB. hastening the legalization of slavery in these colonies.C. mitigating some of the conditions of slavery for black people in these coloniesD. delaying the introduction of slavery into the English colonies20. The author considers the explanation put forward by Freyre andTannenbaum for the treatment accorded B lack slaves in the English colonies of North America to be _____________.A. ambitious but misguidedB. valid有根据的but limitedC. popular but suspectD. anachronistic过时的,时代错误的and controversialUNIT 2Text AThe sea lay like an unbroken mirror all around the pine-girt, lonely shores of Orr’s Island. Tall, kingly spruce s wore their regal王室的crowns of cones high in air, sparkling with diamonds of clear exuded gum流出的树胶; vast old hemlocks铁杉of primeval原始的growth stood darkling in their forest shadows, their branches hung with long hoary moss久远的青苔;while feathery larches羽毛般的落叶松,turned to brilliant gold by autumn frosts, lighted up the darker shadows of the evergreens. It was one of those hazy朦胧的, calm, dissolving days of Indian summer, when everything is so quiet that the fainest kiss of the wave on the beach can be heard, and white clouds seem to faint into the blue of the sky, and soft swathing一长条bands of violet vapor make all earth look dreamy, and give to the sharp, clear-cut outlines of the northern landscape all those mysteries of light and shade which impart such tenderness to Italian scenery.The funeral was over,--- the tread鞋底的花纹/ 踏of many feet, bearing the heavy burden of two broken lives, had been to the lonely graveyard, and had come back again,--- each footstep lighter and more unconstrained不受拘束的as each one went his way from the great old tragedy of Death to the common cheerful of Life.The solemn black clock stood swaying with its eternal ―tick-tock, tick-tock,‖ in the kitchen of the brown house on Orr’s Island. There was there that sense of a stillness that can be felt,---such as settles down on a dwelling住处when any of its inmates have passed through its doors for the last time, to go whence they shall not return. The best room was shut up and darkened, with only so much light as could fall through a little heart-shaped hole in the window-shutter,---for except on solemn visits, or prayer-meetings or weddings, or funerals, that room formed no part of the daily family scenery.The kitchen was clean and ample, hearth灶台, and oven on one side, and rows of old-fashioned splint-bottomed chairs against the wall. A table scoured to snowy whiteness, and a little work-stand whereon lay the Bible, the Missionary Herald, and the Weekly Christian Mirror, before named, formed the principal furniture. One feature, however, must not be forgotten, ---a great sea-chest水手用的储物箱,which had been the companion of Zephaniah through all the countries of the earth. Old, and battered破旧的,磨损的, and unsightly难看的it looked, yet report said that there was good store within which men for the most part respect more than anything else; and, indeed it proved often when a deed of grace was to be done--- when a woman was suddenly made a widow in a coast gale大风,狂风, or a fishing-smack小渔船was run down in the fogs off the banks, leaving in some neighboring cottage a family of orphans,---in all such cases, the opening of this sea-chest was an event of good omen 预兆to the bereaved丧亲者;for Zephaniah had a large heart and a large hand, and was apt有…的倾向to take it out full of silver dollars when once it went in. So the ark of the covenant约柜could not have been looked on with more reverence崇敬than the neighbours usually showed to Captain Pennel’s sea-chest.1. The author describes Orr‟s Island in a(n)______way.A.emotionally appealing, imaginativeB.rational, logically preciseC.factually detailed, objectiveD.vague, uncertain2.According to the passage, the “best room”_____.A.has its many windows boarded upB.has had the furniture removedC.is used only on formal and ceremonious occasionsD.is the busiest room in the house3.From the description of the kitchen we can infer that thehouse belongs to people who_____.A.never have guestsB.like modern appliancesC.are probably religiousD.dislike housework4.The passage implies that_______.A.few people attended the funeralB.fishing is a secure vocationC.the island is densely populatedD.the house belonged to the deceased5.From the description of Zephaniah we can see thathe_________.A.was physically a very big manB.preferred the lonely life of a sailorC.always stayed at homeD.was frugal and saved a lotText BBasic to any understanding of Canada in the 20 years after the Second World War is the country' s impressive population growth. For every three Canadians in 1945, there were over five in 1966. In September 1966 Canada's population passed the 20 million mark. Most of this surging growth came from natural increase. The depression of the 1930s and the war had held back marriages, and the catching-up process began after 1945. The baby boom continued through the decade of the 1950s, producing a population increase of nearly fifteen percent in the five years from 1951 to 1956. This rate of increase had been exceeded only once before in Canada's history, in the decade before 1911 when the prairies were being settled. Undoubtedly, the good economic conditions of the 1950s supported a growth in the population, but the expansion also derived from a trend toward earlier marriages and an increase in the average size of families; In 1957 the Canadian birth rate stood at 28 per thousand, one of the highest in the world. After the peak year of 1957, thebirth rate in Canada began to decline. It continued falling until in 1966 it stood at the lowest level in 25 years. Partly this decline reflected the low level of births during the depression and the war, but it was also caused by changes in Canadian society. Young people were staying at school longer, more women were working; young married couples were buying automobiles or houses before starting families; rising living standards were cutting down the size of families. It appeared that Canada was once more falling in step with the trend toward smaller families that had occurred all through theWestern world since the time of the Industrial Revolution. Although the growth in Canada’s population had slowed down by 1966 (the cent), another increase in the first half of the 1960s was only nine percent), another large population wave was coming over the horizon. It would be composed of the children of the children who were born during the period of the high birth rate prior to 1957.6. What does the passage mainly discuss?A. Educational changes in Canadian society.B. Canada during the Second World War.C. Population trends in postwar Canada.D. Standards of living in Canada.7. According to the passage, when did Canada's baby boom begin?A. In the decade after 1911.B. After 1945.C. During the depression of the 1930s.D. In 1966.8. The author suggests that in Canada during the 1950s____________.A. the urban population decreased rapidlyB. fewer people marriedC. economic conditions were poorD. the birth rate was very high9. When was the birth rate in Canada at its lowest postwar level?A. 1966.B. 1957.C. 1956.D. 1951.10. The author mentions all of the following as causes of declines inpopulation growth after 1957 EXCEPT_________________.A. people being better educatedB. people getting married earlierC. better standards of livingD. couples buying houses11.I t can be inferred from the passage that before the IndustrialRevolution_______________.A. families were largerB. population statistics were unreliableC. the population grew steadilyD. economic conditions were badText CI was just a boy when my father brought me to Harlem for the first time, almost 50 years ago. We stayed at the hotel Theresa, a grand brick structure at 125th Street and Seventh avenue. Once, in the hotel restaurant, my father pointed out Joe Louis. He even got Mr. Brown, the hotel manager, to introduce me to him, a bit punchy强力的but still champ焦急as fast as I was concerned.Much has changed since then. Business and real estate are booming. Some say a new renaissance is under way. Others decry责难what they see as outside forces running roughshod肆意践踏over the old Harlem. New York meant Harlem to me, and as a young man I visited it whenever I could. But many of my old haunts are gone. The Theresa shut down in 1966. National chains that once ignored Harlem now anticipate yuppie money and want pieces of this prime Manhattan real estate. So here I am on a hot August afternoon, sitting in a Starbucks that two years ago opened a block away from the Theresa, snatching抓取,攫取at memories between sips of high-priced coffee. I am about to open up a piece of the old Harlem---the New York Amsterdam News---when a tourist。
Gut Microbiota in Health and Disease
Physiol Rev90:859–904,2010;doi:10.1152/physrev.00045.2009.Gut Microbiota in Health and DiseaseINNA SEKIROV,SHANNON L.RUSSELL,L.CAETANO M.ANTUNES,AND B.BRETT FINLAYMichael Smith Laboratories,Department of Microbiology and Immunology,and Department of Biochemistry and Molecular Biology,The University of British Columbia,Vancouver,British Columbia,CanadaI.Preface860II.Overview of the Mammalian Gut Microbiota860A.Humans as microbial depots860B.Who are they?860C.Where are they?861D.Where do they come from?861E.How are they selected?862III.Microbiota in Health:Combine and Conquer862A.Immunomodulation863B.Protection866C.Structure and function of the GIT867D.Outside of the GIT868E.Nutrition and metabolism868F.Concluding remarks870IV.Microbiota in Disease:Mechanisms of Fine Balance870A.Imbalance leads to chaos870B.Microbial intruders of the GIT871C.Disorders of the GIT872D.Disorders of the GIT accessory organs876plex multifactorial disorders and diseases of remote organ systems877F.Bacterial translocation and disease880G.Concluding remarks881V.Signaling in the Mammalian Gut881A.Signaling between the microbiota and the host881B.Signaling between the microbiota and pathogens884C.Signaling between members of the microbiota884D.Signaling between the host and pathogens885VI.Models to Study Microbiota885A.Germ-free animals885B.Mono-associated and bi-associated animals887C.Poly-associated animals887D.Human flora-associated animals888VII.Techniques to Study Microbiota Diversity889A.Culture-based analysis889B.Culture-independent techniques889C.Sequencing methods889D.“Fingerprinting”Methods892E.DNA microarrays893F.FISH and qPCR893G.The“meta”family of function-focused analyses893VIII.Future Perspectives:Have We Got the Guts for It?895 Sekirov I,Russell SL,Antunes LCM,Finlay BB.Gut Microbiota in Health and Disease.Physiol Rev90:859–904, 2010;doi:10.1152/physrev.00045.2009.—Gut microbiota is an assortment of microorganisms inhabiting the length andwidth of the mammalian gastrointestinal tract.The composition of this microbial community is host specific, evolving throughout an individual’s lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this“organ”has illuminated its central position in healthand disease.The microbiota is intimately involved in numerous aspects of normal host physiology,from nutritionalstatus to behavior and stress response.Additionally,they can be a central or a contributing cause of many diseases,affecting both near and far organ systems.The overall balance in the composition of the gut microbial community,as well as the presence or absence of key species capable of effecting specific responses,is important in ensuring homeostasis or lack thereof at the intestinal mucosa and beyond.The mechanisms through which microbiota exerts its beneficial or detrimental influences remain largely undefined,but include elaboration of signaling molecules and recognition of bacterial epitopes by both intestinal epithelial and mucosal immune cells.The advances in modeling and analysis of gut microbiota will further our knowledge of their role in health and disease,allowing customization of existing and future therapeutic and prophylactic modalities.I.PREFACEHippocrates has been quoted as saying “death sits in the bowels”and “bad digestion is the root of all evil”in 400B.C.(105),showing that the importance of the intes-tines in human health has been long recognized.In the past several decades,most research on the impact of bacteria in the intestinal environment has focused on gastrointestinal pathogens and the way they cause dis-ease.However,there has recently been a considerable increase in the study of the effect that commensal mi-crobes exert on the mammalian gut (Fig.1).In this re-view,we revisit the current knowledge of the role played by the gastrointestinal microbiota in human health and disease.We describe the state-of-the-art techniques used to study the gastrointestinal microbiota and also present challenging questions to be addressed in the future of microbiota research.II.OVERVIEW OF THE MAMMALIANGUT MICROBIOTA A.Humans as Microbial DepotsVirtually all multicellular organisms live in close as-sociation with surrounding microbes,and humans are noexception.The human body is inhabited by a vast number of bacteria,archaea,viruses,and unicellular eukaryotes.The collection of microorganisms that live in peaceful coexistence with their hosts has been referred to as the microbiota,microflora,or normal flora (154,207,210).The composition and roles of the bacteria that are part of this community have been intensely studied in the past few years.However,the roles of viruses,archaea,and unicellular eukaryotes that inhabit the mammalian body are less well known.It is estimated that the human mi-crobiota contains as many as 1014bacterial cells,a num-ber that is 10times greater than the number of human cells present in our bodies (162,264,334).The microbiota colonizes virtually every surface of the human body that is exposed to the external environment.Microbes flour-ish on our skin and in the genitourinary,gastrointesti-nal,and respiratory tracts (43,126,210,323).By far the most heavily colonized organ is the gastrointestinal tract (GIT);the colon alone is estimated to contain over 70%of all the microbes in the human body (162,334).The human gut has an estimated surface area of a tennis court (200m 2)(85)and,as such a large organ,represents a major surface for microbial colonization.Additionally,the GIT is rich in molecules that can be used as nutrients by microbes,making it a preferred site for colonization.B.Who Are They?The majority of the gut microbiota is composed of strict anaerobes,which dominate the facultative anaer-obes and aerobes by two to three orders of magnitude (96,104,263).Although there have been over 50bacterial phyla described to date (268),the human gut microbiota is dominated by only 2of them:the Bacteroidetes and the Firmicutes,whereas Proteobacteria,Verrucomicrobia,Actinobacteria,Fusobacteria,and Cyanobacteria are present in minor proportions (64)(Fig.2,A and B ).Esti-mates of the number of bacterial species present in the human gut vary widely between different studies,but it has been generally accepted that it contains ϳ500to 1,000species (341).Nevertheless,a recent analysis involving multiple subjects has suggested that the collective human gut microbiota is composed of over 35,000bacterial spe-cies(76).FIG .1.Number of publications related to the intestinal microbiotain the last two decades,per year.Data were obtained by searching Pubmed (/pubmed/)with the following terms:intestinal microbiota,gut microbiota,intestinal flora,gut flora,intestinal microflora,and gut microflora.860SEKIROV ET AL.C.Where Are They?The intestinal microbiota is not homogeneous.The number of bacterial cells present in the mammalian gut shows a continuum that goes from 101to 103bacteria per gram of contents in the stomach and duodenum,progress-ing to 104to 107bacteria per gram in the jejunum and ileum and culminating in 1011to 1012cells per gram in the colon (220)(Fig.2A ).Additionally,the microbial compo-sition varies between these sites.Frank et al.(76)have reported that different bacterial groups are enriched at different sites when comparing biopsy samples of the small intestine and colon from healthy individuals.Sam-ples from the small intestine were enriched for the Bacilli class of the Firmicutes and Actinobacteria.On the other hand,Bacteroidetes and the Lachnospiraceae family of the Firmicutes were more prevalent in colonic samples (76).In addition to the longitudinal heterogeneity dis-played by the intestinal microbiota,there is also a great deal of latitudinal variation in the microbiota composition (Fig.2B ).The intestinal epithelium is separated from the lumen by a thick and physicochemically complex mucus layer.The microbiota present in the intestinal lumen dif-fers significantly from the microbiota attached and em-bedded in this mucus layer as well as the microbiota present in the immediate proximity of the epithelium.Swidsinski et al.(303)have found that many bacterialspecies present in the intestinal lumen did not access the mucus layer and epithelial crypts.For instance,Bacte-roides ,Bifidobacterium ,Streptococcus ,members of En-terobacteriacea,Enterococcus ,Clostridium ,Lactobacil-lus,and Ruminococcus were all found in feces,whereas only Clostridium ,Lactobacillus,and Enterococcus were detected in the mucus layer and epithelial crypts of the small intestine (303).D.Where Do They Come From?Colonization of the human gut with microbes begins immediately at birth (Fig.2C ).Upon passage through the birth canal,infants are exposed to a complex microbial population (245).Evidence that the immediate contact with microbes during birth can affect the development of the intestinal microbiota comes from the fact that the intestinal microbiota of infants and the vaginal microbiota of their mothers show similarities (187).Additionally,infants delivered through cesarean section have different microbial compositions compared with vaginally deliv-ered infants (128).After the initial establishment of the intestinal microbiota and during the first year of life,the microbial composition of the mammalian intestine is rel-atively simple and varies widely between different indi-viduals and also with time (179,187).However,after 1yr of age,the intestinal microbiota of children startstoFIG .2.Spatial and temporal aspects of intestinal microbiota composition.A :variations in microbial numbers and composition across the lengthof the gastrointestinal tract.B :longitudinal variations in microbial composition in the intestine.C :temporal aspects of microbiota establishment and maintenance and factors influencing microbial composition.GUT MICROBIOTA861resemble that of a young adult and stabilizes(179,187) (Fig.2C).It is presumed that this initial colonization is involved in shaping the composition of the gut microbiota through adulthood.For instance,a few studies have shown that kinship seems to be involved in determining the composition of the gut microbiota.Ley et al.(161) have shown that,in mice,the microbiota of offspring is closely related to that of their mothers.Additionally,it has been shown that the microbiota of adult monozygotic and dizygotic twins were equally similar to that of their sib-lings,suggesting that the colonization by the microbiota from a shared mother was more decisive in determining their adult microbiota than their genetic makeup(350). Although these studies point to the idea that parental inoculation is a major factor in shaping our gut microbial community,there are several confounding factors that prohibit a definite conclusion on this subject.For exam-ple,it is difficult to take into account differences in diet when human studies are performed.On the other hand, mouse studies are performed in highly controlled envi-ronments,where exposure to microbes from sources other than littermates and parents is limited.Therefore, further investigation is needed to decisively establish the role of parental inoculation in determining the composi-tion of the adult gut microbiota.E.How Are They Selected?Besides the mother’s microbiota composition,many other factors have been found to contribute to the micro-bial makeup of the mammalian GIT(Fig.2C).Several studies have shown that host genetics can impact the microbial composition of the gut.For instance,the pro-portions of the major bacterial groups in the murine in-testine are altered in genetically obese mice,compared with their genetically lean siblings(161).Also,mice con-taining a mutation in the major component of the high-density lipoprotein(apolipoprotein a-I)have an altered microbiota(347).Although these studies suggest that host genetics can have an impact on the gut microbiota,it should be noted that such effects are likely to be indirect, working through effects on general host metabolism.Studies on obesity have also revealed that diet can affect gut microbial composition.Consumption of a pro-totypic western diet that induced weight gain significantly altered the microbial composition of the murine gut(311). Further dietary manipulations that limited weight gain were able to reverse the effects of diet-induced obesity on the microbiota.Given the plethora of factors that can affect micro-bial composition in the human gut,it is perhaps surprising that the composition of the human microbiota is fairly stable at the phylum level.The major groups that domi-nate the human intestine are conserved between all indi-viduals,although the proportions of these groups can vary.However,when genera and species composition within the human gut is analyzed,differences occur. Within phyla,the interindividual variation of species com-position is considerably high(64,89).This suggests that although there is a selective pressure for the maintenance of certain microbial groups(phyla)in the microbiota,the functional redundancy within those groups allows for variations in the composition of the microbiota between individuals without compromising the maintenance of proper function.However,this hypothesis remains to be experimentally tested.III.MICROBIOTA IN HEALTH:COMBINE AND CONQUERSeveral lines of evidence point towards a possible coevolution of the host and its indigenous microbiota:it has been shown that transplantation of microbial commu-nities between different host species results in the trans-planted community morphing to resemble the native mi-crobiota of the recipient host(242),and that gut micro-biota species exhibit a high level of adaptation to their habitat and to each other,presenting a case of“microevo-lution”that paralleled the evolution of our species on the large scale(257,342).Moreover,the host has evolved intricate mechanisms that allow local control of the resi-dent microbiota without the induction of concurrent dam-aging systemic immune responses(181).This adaptation is not surprising when considering that different bacterial groups and species have been implicated in various aspects of normal intestinal devel-opment and function of their host(Fig.3).In recent years, we have seen a tremendous increase in gut microbiota-related research,with important advances made towards establishing the identity of specific microbes/microbial groups or microbial molecules contributing to various aspects of host physiology.Concurrently,host factors involved in various aspects of development and matura-tion targeted by the microbiota have been identified.How-ever,a large proportion of research aimed at identifying particular microbiota contributors to host health was done in ex-germ-free(GF)animals mono-or poly-associ-ated with different bacterial species representative of dominant microbiota phyla(e.g.,Bacteroides thetaio-taomicron,Bacteroides fragilis,Lactobacillus spp.)or stimulated with particular microbial components[e.g., lipopolysaccharide(LPS)and polysaccharide A(PSA)]. Thus any discovered contribution of these particular mi-crobial species or molecules to a distinct host structure/ function points to their ability to provide the said contri-bution,but not to the fact that they are the primary microbe/molecule responsible for it in a host associated with a complete microbial community.Additionally,as862SEKIROV ET AL.current culturing techniques limit our ability to isolate strictly anaerobic microbiota members or members with complex nutrient requirements and mutualistic depen-dence on other microbial gut inhabitants (62),the re-search on the contribution of specific gut microbes to various physiological processes is limited to studying a small number of currently isolated and culturable micro-organisms.However,improvements to available culturing techniques (62)and enhanced understanding of microbial metabolism gained from culture-independent studies hold promise to greatly expand this field of research.A.ImmunomodulationThe importance of the gut microbiota in the develop-ment of both the intestinal mucosal and systemic immune systems can be readily appreciated from studies of GF (microbiota lacking)animals.GF animals contain abnor-mal numbers of several immune cell types and immune cell products,as well as have deficits in local and sys-temic lymphoid structures.Spleens and lymph nodes of GF mice are poorly formed.GF mice also have hypoplas-tic Peyer’s patches (PP)(180)and a decreased number of mature isolated lymphoid follicles (27).The number of their IgA-producing plasma cells is reduced,as are the levels of secreted immunoglobulins (both IgA and IgG)(180).They also exhibit irregularities in cytokine levels and profiles (220)and are impaired in the generation of oral tolerance (132).The central role of gut microbiota in the development of mucosal immunity is not surprising,considering that the intestinal mucosa represents the largest surface area in contact with the antigens of the external environment and that the dense carpet of the gut microbiota overlying the mucosa normally accounts for the largest proportion of the antigens presented to the resident immunecellsFIG .3.The complex web of gut microbiota contributions to host physiology.Different gut microbiota components can affect many aspects of normal host development,while the microbiota as a whole often exhibits functional redundancy.In gray are shown members of the microbiota,with their components or products of their metabolism.In white are shown their effects on the host at the cellular or organ level.Black ellipses represent the affected host phenotypes.Only some examples of microbial members/components contributing to any given phenotype are shown.AMP,antimicrobial peptides;DC,dendritic cells;Gm Ϫ,Gram negative;HPA,hypothalamus-pituitary-adrenal;Iap,intestinal alkaline phosphatase;PG,peptidoglycan;PSA,polysaccharide A.GUT MICROBIOTA863and those stimulating the pattern recognition receptors [such as the TLRs and NOD-like receptors(NLRs)]of the intestinal epithelial cells(238).A detailed overview of the intestinal mucosal immunity can be found elsewhere(110, 194).Briefly,it is composed of the gut-associated lym-phoid tissue(GALT),such as the PP and small intestinal lymphoid tissue(SILT)in the small intestine,lymphoid aggregates in the large intestine,and diffusely spread immune cells in the lamina propria of the GIT.These immune cells are in contact with the rest of the immune system via local mesenteric lymph nodes(MLN).In addi-tion to the immune cells,the intestinal epithelium also plays a role in the generation of immune responses through sampling of foreign antigens via TLRs and NLRs (238).The mucosal immune system needs to fulfill two, sometimes seemingly conflicting,functions.It needs to be tolerant of the overlying microbiota to prevent the induc-tion of an excessive and detrimental systemic immune response,yet it needs to be able to control the gut micro-biota to prevent its overgrowth and translocation to sys-temic sites.Gut microbiota is intricately involved in achieving these objectives of the GIT mucosal immune system.1.Mucosal/systemic immunity maturationand developmentA major immune deficiency exhibited by GF animals is the lack of expansion of CD4ϩT-cell populations.This deficiency can be completely reversed by treatment of GF mice with PSA of Bacteroides fragilis(197).Mazmanian et al.(197),in an elegant series of experiments,have shown that either mono-association of GF mice with B. fragilis or oral treatment with its capsular antigen PSA induces proliferation of CD4ϩT cells,as well as restores the development of lymphocytes-containing spleen white pulp.Recognition of PSA by dendritic cells(DCs)with subsequent presentation to immature T lymphocytes in MLNs was required to promote the expansion.GF animals exhibit systemic skewing towards a Th2cytokine profile, a phenotype that was shown to be reversed by PSA treat-ment,in a process requiring signaling through the inter-leukin(IL)-12/Stat4pathway(197).Thus exposure to a single structural component of a common gut microbiota member promotes host immune maturation both locally and systemically,at the molecular,cellular,and organ levels.While B.fragilis PSA appears to have a pan-systemic effect on its host’s immunological development,addi-tional gut microbiota constituents and their components have been shown to have immunomodulatory capacity, highlighting the overlapping,and possibly additive or syn-ergistic,functions of the members of the gut microbial community.For instance,various Lactobacilli spp.have been shown to differentially regulate DCs,with conse-quent influence on the Th1/Th2/Th3cytokine balance at the intestinal mucosa(44),as well as on the activation of natural killer(NK)cells(72).Additionally,peptidoglycan of Gram-negative bacteria induces formation of isolated lymphoid follicles(ILF)via NOD1(an NLR)signaling. Following recognition of microbiota through TLRs,these ILF matured into B-cell clusters(27).A complex microbial community containing a signif-icant proportion of bacteria from the Bacteroidetes phy-lum was shown to be required for the differentiation of inflammatory Th17cells(133).Interestingly,the coloniza-tion of GF mice with altered Schaedlerflora(ASF)was insufficient to promote differentiation of Th17cells,de-spite the fact that ASF includes a number of bacteria from the Bacteroidetes phylum(59).Thisfinding highlights the complexity of interactions between the host and the mi-crobiota and within the microbiota community,indicating that cooperation between microbiota members may be required to promote normal host development.In view of this,thefinding by Atarashi et al.(9),that administration of ATP(which is found in high concentrations in the GIT of SPF,but not GF mice)was sufficient to trigger differ-entiation of Th17cells in GF mice,is all the more intrigu-ing.This raises questions about the metabolic capabilities of different members of the gut microbiota and lends indirect evidence to their metabolic interdependence. 2.Tolerance at the GIT mucosaThe GIT needs to coexist with the dense carpet of bacteria overlying it without an induction of excessive detrimental immune activation both locally and systemi-cally.Prevention of excessive immune response to the myriad of bacteria from the gut microbiota can be achieved either through physical separation of bacteria and host cells,modifications of antigenic moieties of the microbiota to render them less immunogenic,or modula-tion of localized host immune response towards toler-ance.Resident immune cells of the GIT often have a phe-notype distinct from cells of the same lineage found sys-temically.For instance,DCs found in the intestinal mu-cosa preferentially induce differentiation of resident T cells into Th2(134)and Treg(144)subsets,consequently promoting a more tolerogenic state in the GIT.In a series of in vitro experiments,DCs were conditioned towards this tolerogenic phenotype by intestinal epithelial cells(IEC) stimulated with various gut microbiota isolates,such as different Lactobacillus spp.and different Escherichia coli strains(346).The conditioning was dependent on micro-biota-induced secretion of TSLP and transforming growth factor(TGF)-by IECs(346).Interestingly,the Gram-posi-tive Lactobacilli were more effective than the Gram-nega-tive E.coli in conditioning the DCs towards a tolerogenic864SEKIROV ET AL.phenotype,likely due to the greater abundance of Lactoba-cilli at the intestinal mucosa,as hypothesized by the authors of the study.Another effective mechanism of preventing colitogenic responses is employed by B.thetaiotaomicron, which prevents activation of the proinflammatory transcrip-tion factor NFB by promoting nuclear export of a transcrip-tionally active NFB subunit RelA in a PPAR␥-dependent fashion(143).An alternate mechanism of preventing NFB activation in response to the gut microbiota is through TLR compartmentalization.Lee et al.(159)have shown that while activation of basolaterally located TLR9promotes NFB activation,signaling originating from the apical sur-faces(i.e.,induced by normal gut microbiota)effectively prevents NFB activation,promoting tolerance to the resi-dent bacteria.In addition to microbiota-mediated tolerogenic skew-ing of localized immune responses,the host can also decrease the proinflammatory potential of microbiota constituents.The presence of the gut microbiota exposes the host to a vast amount of LPS found on the outer membranes of Gram-negative bacteria.Systemic reac-tions to LPS lead to highly lethal septic shock(19),a very undesirable outcome of host-microbiota interactions.One way to avoid this disastrous scenario is to minimize the toxic potential of LPS,which can be done via dephosphor-ylation of the LPS endotoxin component through the ac-tion of alkaline phosphatases,specifically the intestinal alkaline phosphatase(Iap)(18).Bates et al.(18)have demonstrated that Iap activity in the GIT of zebrafish reduced MyD88-and tumor necrosis factor(TNF)-␣-me-diated recruitment of neutrophils to the intestinal epithe-lium,minimizing the inflammatory response to the gut microbiota and promoting tolerance.Iap activity in ze-brafish GIT was induced via MyD88signaling and was dependent on the presence of microbiota:it could be induced by mono-association with Gram-negative(GmϪ) bacterial isolates(such as Aeromonas and Pseudomonas) or treatment with LPS.Association with Gram-positive (Gmϩ)bacterial isolates(such as Streptococcus and Staphylococcus)failed to promote Iap activity(18),dem-onstrating that at least some host responses to its colo-nizing microbes are group specific.In addition to detoxification of LPS by Iap,IECs also acquire tolerance to endotoxin through downregulation of IRAK-1,which is essential for endotoxin signaling through TLR4(174).This tolerance is acquired at birth, but only in vaginally delivered mice that were exposed to exogenous LPS during passage through the birth canal (174),again highlighting the active role of the microbiota in tolerogenic conditioning of mucosal immune responses at the GIT.Another effective strategy of avoiding excessive im-mune activation at the intestinal mucosa is physical sep-aration of the microbiota from the host mucosal immune system.Recently,Johansson et al.(136)have shown that the mucus layer overlying the colonic mucosa is effec-tively divided into two tiers,with the bottom tier being devoid of bacteria,and the more dynamic top tier being permeated by members of the gut microbiota.3.Control of the gut microbiotaWhile healthy gut microbiota is essential to promote host health and well-being,overgrowth of the bacterial population results in a variety of detrimental conditions, and different strategies are employed by the host to pre-vent this outcome.Plasma cells residing at the intestinal mucosa pro-duce secretory IgA(sIgA)that coats the gut microbiota and allows local control of their numbers(181,310).They are activated by resident DCs that sample the luminal bacteria,but are restricted in their migration to only as far as the local MLNs,so as to avoid induction of a systemic response to the gut microbiota(181).The presence of the gut microbiota is a prerequisite to activate gut DCs to induce maximal levels of IgA production,while treatment of GF mice with LPS augmented IgA production but to lower levels(195).Furthermore,Bacteroides(GmϪbac-teria)were found to be more efficient in induction of sIgA than Lactobacilli(Gmϩbacteria)(343).Interestingly,al-though GmϪbacteria or their structural components were able to stimulate IgA production,the absence of intestinal IgA resulted in overgrowth of SFB,a group of Gmϩbacteria(300),suggesting that induction of sIgA might also be a form of competition between different microbiota members.Two secretory IgA(sIgA)subclasses exist:sIgA1 (produced systemically and at mucosal surfaces)and sIgA2(produced at mucosal surfaces).sIgA2is more resistant to degradation by bacterial proteases than sIgA1 (202),so it is not surprising that it was found to be the main IgA subclass produced in the intestinal lamina pro-pria(107).Production of a proliferation-inducing ligand (APRIL)by IECs activated via TLR-mediated sensing of bacteria and bacterial products was required to induce switching from sIgA1to sIgA2production(107).Both Gmϩand GmϪbacteria,as well as bacterial LPS and flagellin,were similarly effective in inducing APRIL pro-duction(107).Thus exposure of the gut mucosa to its resident microbiota not only promotes IgA secretion,but also ensures that the optimally stable IgA subclass is produced.It is also of interest to note that sIgA fulfills a dual function at the intestinal mucosa:in addition to preventing overgrowth of the gut microbiota,it also min-imizes its interactions with the mucosal immune system, diminishing the host’s reaction to its resident microbes (234).sIgA is not the only host factor preventing the micro-biota from breaching its luminal compartment:antimicro-bial peptides(AMP)produced by the host also work toGUT MICROBIOTA865。
2024届上海春季高考(押题卷03)-英语试题+答案
2024学年上海市高考押题卷03英语学科(满分115分)II. Grammar and Vocabulary (20分)Section ADirections: After reading the passage below, fill in the blanks to make the passage coherent and grammatically correct. For the blanks with a given word, fill in each blank with the proper form of the given word; for the other blanks, use one word that best fits each blank.The United States of America (commonly ____1____(refer) to as the United States, the U.S.,the USA,the States or America) is a federal constitutional republic comprising fifty states and a federal district.The country is situated mostly in central North America,____2____ its forty-eight contiguous states and Washington,D.C., the capital district, lie ____3____ the Pacific and Atlantic Oceans,bordered by Canada to the north and Mexico to the south. The state of Alaska is in the northwest of the continent, with Canada to its east and Russia to the west across the Bering Strait.At 3.79 million square miles (9.83 million km²) and with more than 300 million people,the United States is the third or fourth ____4____ (large) country by total area,and third largest by land area and by population.The United States is one of the world's most ethnically diverse and multicultural nations, the product of large-scale immigration from many countries. The U.S.economy is the largest national economy in the world, with an estimated 2008 gross domestic product (GDP) of US $14.3 trillion.The nation was founded by thirteen colonies of Great Britain located along the Atlantic seaboard. On July 4,1776,they issued the Declaration of Independence, ____5____ proclaimed their independence from Great Britain and their formation of a cooperative union.The rebellious states ____6____ (defeat) Great Britain in the American Revolutionary War,the first successful colonial war of independence. A federal convention adopted the current United States Constitution on September 17,1787; its ratification the ____7____ (follow) year made the states part of a single republic with a strong central government. The Bill of Rights, comprising ten constitutional amendments guaranteeing many fundamental civil rights and freedoms, was ratified in 1791.In the 19th century, the United States acquired land from France, Spain, the United Kingdom, Mexico, and Russia, and annexed the Republic of Texas and the Republic of Hawaii. Disputes between the agrarian South and industrial North over states’ rights and the expansion of the institution of slavery provoked the American Civil War of the 1860s. The North's victory prevented a permanent split of the country and led ____8____ the end of legal slavery in the United States. By the 1870s, ___9___ national economy was the world's largest. The Spanish–American War and World War I confirmed the country's status as a military power. In 1945, the United States emerged from World War II as the first country _____10_____ (have) weapons,a permanent member of the United Nations Security Council, and a founding member of NATO.The end of the Cold War left the United States as the sole superpower. The country accounts for approximately 50% of global military spending and is a leading economic,political,and cultural force in the world.Directions: Complete the passage with the words in the box. Each word can only be used once. Note that there is one word more than you need.A. catch-up;B. substitute;C. advance;D. committed;E. exhausted;F. multitask;G. transferred;H. maintaining;I. commenting;K. challenge;J. embraceMy friend Haley called me the other day. She hadn't texted me in ___11___ to “find a time “to chat. Nor did we have a Zoom date on the calendar. She just up and called me unannounced.It was thrilling, this unscheduled, spontaneous conversation without a purpose or the weight of a formal ____12____. It felt like wheeling over to someone in the office to hear a joke.I was reminded of that larger orbit of friendships outside the inner core of those we still see in person, usually because we live with them. Think about all those relationships once sustained by serendipity and proximity, now starved by a year of social distancing.In what may be the world's largest sociological experiment, many of us have had to rely almost completely on technology to tend these connections. We now have a whole new cadre of Appointment Friendships.And even with ____13____ scheduling, it's not really enough. A recent study from researchers at the University of Nevada, Las Vegas, confirms what we now know in our ____14____ hearts: video calls, texts, social media, even phone calls are a great supplement to face-to-face interactions, but they aren't a(n) ____15____.Contrary to what you might expect, the more sophisticated the technology, the less it satisfies our need for connection.Researchers reported that the humble phone call was associated with decreases in stress, loneliness, and relationship difficulties. Meanwhile, video chats were associated with increased stress, loneliness, and difficulties in ____16____.I get it, we’re less self-conscious on the phone, and you can ____17____ and talk — maybe fold laundry or eat or both. With video, that uncanny valley of almost being there tends to make you long for the real thing. The UNLV researchers also reported that social media posting, ____18____ and sharing was the “modality most strongly associated with stress. “No one is less surprised about all this than Sherry Turkle, a clinical psychologist at M.I.T. She's been studying how technology affects our capacity for empathy and connection since the first Apple computer showed up with a smiley face, reporting her findings in two seminal books “Reclaiming Conversation” and “Alone Together.”When I spoke to her a few weeks ago, she’d just published her memoir, “The Empathy Diaries,” which is about becoming one of very few women at M.I.T. and one who was willing to ____19____ the enduring gospel of the engineering universe: that technology would solve the problems it caused.Turkle finished working on this book during pandemic shutdowns, which were akin to a real-world test of her life's work. She writes:In the crucible of enforced isolation, we explored the limits of where our screens can take us as technology became our lifeline, we realized how much we missed the full ___20___ of the human.III. Reading ComprehensionDirections: For each blank in the following passages there are four words or phrases marked A, B, C and D. Fill in each blank with the word or phrase that best fits the context.Today we live in a world where GPS systems, digital maps, and other navigation apps are available on our smart phones. ___21___of us just walk straight into the woods without a phone. But phones ___22___on batteries, and batteries can die faster than we realize.If you get lost without a phone or a compass, and you ___23___can’t find north, a few tricks to help you navigate ___24___to civilization, one of which is to follow the land...When you find yourself well ___25___a trail, but not in a completely ___26___area, you have to answer two questions: Which ___27___is downhill, in this particular area? And where is the nearest water source? Humans overwhelmingly live in valleys, and on supplies of fresh water. ___28___, if you head downhill, and follow any H2O you find, you should ___29___see signs of people.If you’ve explored the area before, keep an eye out for familiar sights—you may be ____30____how quickly identifying a distinctive rock or tree can restore your bearings.Another ____31____: Climb high and look for signs of human habitation.____32____ , even in dense forest, you should be able to ____33____gaps in the tree line due to roads, train tracks, and other paths people carve through the woods. Head toward these breaks to find a way out. At night, scan the horizon for artificial light sources, such as fires and streetlights, then walk toward the glow of light pollution.Finally, assuming you’re lost in an area humans tend to frequent, look for the ____34____we leave on the landscape. Trail blazes, tire tracks, and other features can ____35____you to civilization.21. A. Some B. Most C. Few D. All22. A. put B. take C. run D. come23. A. formally B. relatively C. gradually D. literally24. A. back B. next C. around D. away25. A. onto B. off C. across D. alone26. A. unattractive B. uncrowded C. unchanged D. unfamiliar27. A. site B. point C. way D. place28. A. So B. Yet C. Instead D. Besides29. A. immediately B. intentionally C. unexpectedly D. eventually30. A. surprised B. annoyed C. frightened D. confused31. A. problem B. option C. view D. result32. A. Above all B. In contrast C. On average D. For example33. A. bridge B. avoid C. spot D. separate34. A. memories B. marks C. notes D. belongings35. A. restrict B. adopt C. lead D. exposeSection BDirections: Read the following three passages. Each passage is followed by several questions or unfinished statements. For each of them there are four choices marked A, B, C and D. Choose the one that fits best according to the information given in the passage you have just read(A)Why make a film about Ned Kelly? More ingenious crime than those committed by the reckless Australian bandit are reported every day. What is there in Ned Kelly to justify dragging the mesmeric Mick Jagger so far into the Australian bush and away from his natural haunts? The answer is that the film makers know we always fall for a bandit, and Jagger is set to do for bold Ned Kelly what Brando once did for the arrogant Emiliano Zapata.The bandit inhabits a special realm of legend where his deeds are embroidered by others; where his death rather than his life is considered beyond belief; where the men who bring him to“justice” are afflicted with doubts about their role.The bandits had a role to play as definite as that of the authorities who condemned them. These were men in conflict with authority, and, in the absence of strong law or the idea of loyal opposition, they took to the hills. Even there, however, many of them obeyed certain unwritten rules.There robbers, who claimed to be something more than mere thieves, had in common, firstly, a sense of loyalty and identity with the peasants they came from. They didn’t steal the peasant’s harvest; they did steal the lord’s.And certain characteristics seem to apply to “social bandits” whether they were in Sicily or Peru. They were generally young men under the age of marriage, predictably the best age for dissidence. Some were simply the surplus male population who had to look for another source of income; others were runway serfs or ex-soldiers; a minority, though the most interesting, were outstanding men who were unwilling to accept the meek and passiverole of peasant.They usually operated in bands between ten and twenty strong and relied for survival on difficult terrain and bad transport. And bandits proposed best where authority was merely local —over the next hill and they were free. Unlike the general run of peasantry they had a taste for flamboyant dress and gesture; but they usually shared the peasants’ religious beliefs and superstitions.The first sign of a man caught up in the Robin Hood syndrome was when he started out, forced into outlawry as a victim of injustice; and when he then set out to “right wrongs”, first his own and then other people’s. The classic bandit then “take from the rich and gives to the poor” in conformity with his own sense of social justice; he never kills except in self-defense or justifiable place; his people admire and help to protect him; he dies through the treason of one of them; he behaves as of invisible and invulnerable; he is a “loyalist”, never the enemy of the king but only of the local oppressors.None of the bandits lived up fully to this image of the “noble robber” and for many the claim of larger motives was often a delusion.Yet amazingly, many of these violent men did behave at least half the time in accordance with this idealist pattern. Pancho Villa in Mexico and Salvatore Giuliano in Italy began their careers harshly victimized. Many of their charitable acts later became legends.The bandit in the real world is rooted in peasant society and when its simple agricultural system is left behind so is he. But the tales and legends, the books and films continue to appear for an audience that is neither peasant nor bandit. In some ways the characters and deeds of the great bandits could so readily be the stuff of grand opera — Don Jose on “Carmen” is based on the Andalusian bandit El Empranillo. But they are perhaps more at home in folk songs, in popular tales and the ritual dramas of films. When we sit in the darkness of the cinema to watch the bold deeds of Ned Kelly we are caught up in admiration for their strong individuality, their simple gesture of protest,their passion for justice and their confidence that they cannot be beaten. This sustains us nearly as much as it did the almost hopeless people from whom they sprang.36. Which of the following words is NOT intended to suggest approval of bandits?A. Bold (Para. 1).B. Claimed (Para. 4).C. Legend (Para. 2).D. Loyalty (Para. 4).37. Of the following reasons which is the LEAST likely one for becoming bandits?A. They liked theatrical clothes and behavior.B. They wanted to help the poor country folk.C. They were unwilling to accept injustice.D. They had very few careers open to them.38. “…began their careers harshly victimized” (Par. 9) means that they _____.A. had received excessive ill-treatmentB. were severely punished for their crimesC. took to violence through a sense of injusticeD. were misunderstood by their parents and friends39. What has made bandits suitable as film heroes is that they_____.A. are sure they are invincibleB. possess a theatrical qualityC. retain the virtues of a peasant societyD. protest against injustice and inequality(B)Literary Festivals across the WoldLondon Book FairTime: held annually in April for three daysPlace: London, U.K.The London Book Fair is a part of the London Book & Screen Week.Visitors include anyone who is involved with the creation, distribution, sale or treatment of content.Authors, talent scouts (星探), editors, designers, and digital gurus(领袖人物)all walk thefloor-----meeting, talking, observing, discovering. It’s a great opportunity to meet all kinds ofpeople.BookExpo AmericaTime: held annually on May or June for four daysPlace: various cities in the U.S.Unlike most book fairs, BookExpo America doesn’t have a base city. It moves to different placesevery year —— mostly big cities such as New York, Washington, Los Angles and Chicago.It is the largest gathering in the United States of librarians, booksellers and industry professionals,as well as a great place to discover the latest trends in technology while networking with others in the business, Go to book signing sessions(签书会)with your favorite authors, and participate in panel discussions with top writers while you enjoy breakfast. With hundreds of participating authors, there’s lots to do, see and read.Frankfurt Book FairTime: held annually in October for a weekPlace: Frankfurt, GermanyThe Frankfurt Book Fair is the world’s biggest and oldest book event with more than 500 years of history, yet it never stops developing with time.Thematic tours are provided, during which trade visitors and the general public can learn more about the Frankfurt Book Fair. Led by experts, these topical tours take interested groups to stands and other locations around the fair that are relevant to specific themes, such as educations, science, kids. With our Book Fair app, visitors have the possibility to take a time-independent, thematic tour.Tokyo international Book FairTime: held annually in September for three daysPlace: Tokyo, JapanBeing Asia’s leading book fair, the Tokyo International Book Fair has several sub categories, including the Natural Sciences Book Fair, the Humanities & Social Sciences Book Fair, and the Children’s Book’s Fair.One of the highlights of the event is the e-books expo, which shines a spotlight on the fact that people’s reading habits are switching from printed books to digital books.Besides book products, the newest e-learning software and digital technologies are also presented.40. How is BookExpo America different from the other three book fairs?A. It is held in different cities every year.B. It attracts many famous writers.C. It displays the latest trends in technology.D. It is the longest annual book fair.41. Which book fair providers tours of specific themes?A. The London Book Fair.B. BookExpo America.C. The Frankfurt Book Fair.D. The Tokyo International Book Fair.42. What do we know about the Tokyo International Book Fair?A. It is the most popular book fair in Asia.B. It is a great place for e-book lovers.C. It mainly focuses on natural science books.D. It mainly displays printed books for schools.(C)For years, the U. S. has experienced a shortage of registered nurses. The Bureau of Labor Statistics projects that while the number of nurses will increase by 19 percent by 2022, demand will grow faster than supply, and that there will be over one million unfilled nursing jobs by then.So what's the solution? Robots.Japan is ahead of the curve when it comes to this trend. Toyohashi University of Technology has developed Terapio, a robotic medical cart that can make hospital rounds, deliver medications and other items, and retrieve records. It follows a specific individual, such as a doctor or nurse, who can use it to record and access patient data. This type of robot will likely be one of the first to be implemented in hospitals because it has fairly minimal patient contact.Robots capable of social engagement help with loneliness as well as cognitive functioning, but the robot itself doesn't have to engage directly—it can serve as an intermediary for human communication. Telepresence robots such as MantaroBot, Vgo, and Giraff can be controlled through a computer, smartphone, or tablet, allowing family members or doctors to remotely monitor patients or Skype them, often via a screen where the robot's ' face' would be. If you can't get to the nursing home to visit grandma, you can use a telepresence robot to hang out with her. A 2016 study found that users had a "consistently positive attitude" about the Giraff robot's ability to enhance communication and decrease feelings of loneliness.A robot's appearance affects its ability to successfully interact with humans, which is why the RIKEN-TRI Collaboration Center for Human-Interactive Robot Research decided to develop a robotic nurse that looks like a huge teddy bear. RIBA (Robot for Interactive Body Assistance), also known as ‘Robear', can help patients into and out of wheelchairs and beds with its strong arms.It's important to note that robotic nurses don't decide courses of treatment or make diagnoses (though robot doctors and surgeons may not be far off). Instead, they perform routine and laborious tasks, freeing nurses up to attend to patients with immediate needs. This is one industry where it seems the integration of robots will lead to collaboration, not replacement.43. What does the author say about Japan?A. It delivers the best medications for the elderly.B. It takes the lead in providing robotic care.C. It provides retraining for registered nurses.D. It sets the trend in future robotics technology.44. What do we learn about the robot Terapio?A. It has been put to use in many Japanese hospitals.B. It provides specific individualized care to patients.C. It does not have much direct contact with patients.D. It has not revolutionized medical service in Japan.45. What are telepresence robots designed to do?A. Directly interact with patients to prevent them from feeling lonely.B. Cater to the needs of patients for recovering their cognitive capacity.C. Closely monitor the patients' movements and conditions around the clock.D. Facilitate communication between patients and doctors or family members.46. What can we infer from the last paragraph?A. Doctors and surgeons will soon be laid off.B. The robotics industry will soon take off.C. Robots will not make nurses redundant.D. Collaboration will not replace competition.Section CDirections: Complete the following passage by using the sentences given below. Each sentence can be used only once. Note that there are two more sentences than you need.In a few years you will be able to order a transcript of your entire genetic code for less than $1,000. ___47___ Two different university laboratories have developed tests that will reveal the entirety of a baby’s genetic code using just a blood sample from the mother plus a drop of saliva (唾液) from the father.Prenatal (出生前的) whole-genome sequencing will provide volumes of information beyond the currently available tests exclusively for genetic disorders such as Down’s syndrome or Tay-Saches disease. The three billion units of code furnished in the new tests will also dwarf(使…相形见的) the relative trickle (零散) of information provided by consumer gene-testing services such as 23andMe, which currently look only at perhaps about one million locations in the genome.___48___ Without careful planning, the new prenatal genetics might rob a child of the chance to make decisions best left until adulthood — whether or not to learn, for instance, if a mutation (突变) predicts the inevitability of Huntington’s disease 20 years hence.___49___ Similar laissez faire(放任) action to prenatal whole-genome testing could portend (预示) tragedy.Ultimately certain agency will need to develop a comprehensive policy on prenatal whole genome testing. Bioethics scholars wrote an analysis last summer that calls on the medical community to develop a guide to the most relevant genomic data for future parents. ___50___ Without access to a much higher level of refined expertise, the secrets of our offspring’s genetic code will continue to remain an unnerving cipher — or worse.A. Unfortunately, there aren’t nearly enough trained genetics counselors to handle the coming upsurge in demand for this type of information.B. Adults cannot do much to alter their biological lot, but what if parents could examine their unborn child’s genome?C. Cancer has become the first killer these years. That’s why people tend to take overtreatment with the knowledge of family history.D. Another fear is that a customer without discussing with genetics counselor can receive information via the Internet about a multifold greater risk of breast cancer.E. Another problem arises whether it is moral to choose to stop pregnancy because of the genome problem.F. Attitudes toward child rearing might change along with the new technology.IV Summary Writing51. Directions: Read the following passage. Summarize the main idea and main point(s) of the passage in no more than 60 words. Use your own words as far as possible.'This is crisis teaching': students with disabilities are neglected as coronavirus shuts schoolsHomeschooling your children during the Covid-19 pandemic(流行病) is hard. For parents whose children have a disability, it's a 'herculean(困难的) task'As her mom tells it, Sesame Street(儿童节目) is Aubrey's first and only love. Her affection for the program's cast of puppets, for Elmo in particular, is so aggressive and pure that her parents have to restrict her access to it because she gets so peculiar after watching it.Aubrey, whose real name her parents asked be withheld to protect her privacy, is a 16-year-old student in Los Angeles. As a teenager living with autism(自闭症), routine is the bedrock of her day.But in the days of a spiraling coronavirus crisis, predicting what comes next is all but impossible. “Think about how we are with uncertainty and multiply it by a million. For her not knowing is almost unbearable,” said her father, Pirouz Kavehpour.Today, with 124,000 of the nation's schools closed due to coronavirus, Kavehpour has joined the ranks of millions of parents turned into homeschool teachers overnight – no easy feat for any working parent, but especially challenging for parents whose children have disabilities.It remains unclear when schools across the country will reopen. California officials already indicated they won't restart this academic year and a handful of other states have closed doors until fall. And as classrooms shift to online learning, many of the services guaranteed to the nation's roughly 7 million children with disabilities have been effectively suspended.Federal law promises to give students educational services that address individual needs. But it's unclear when children with disabilities will get the kind of face-to-face help they had been getting at school before.(Adapted from the Guardian BY Jerry)V. TranslationDirections: Translate the following sentences into English, using the words given in the brackets.52. 你应该就你的所作所为向在场的所有人表示歉意。
工程硕士研究生实用英语教程-读写译-(课文和翻译)
unit 1 graduate education 研究生教育TEXTGraduate Study Challenges and Strategies for Success反思:读研的挑战与成功策略Linda Weston Kramer, RN, BSN, CCRN琳达·威斯顿·克莱默(1) The decision to pursue graduate studies should not be taken lightly. Decisions should be made after serious consideration of personal and professional goals. One must evaluate the variety of programs offered, whether traditional on campus versus online classroom, cost of continuing education, financial aid availability, employment while in school, time allotment to complete studies, computer program technical skills, and computer/library access, to obtain a master's degree. Graduate programs should help the student acquire 3 core competencies.(1)继续读研的决定不应太草率,必须先慎重考虑个人及职业发展目标。
为了获得硕士学位,你必须评估学校提供的研究生教育的多样性,不管它是传统的校园教学还是网络课堂;你还必须评估继续接受教育的费用,是否可以获得经济资助,能否兼职,完成学业的时间分配,个人计算机能力,学校计算机及图书馆资源等各类因素。
小学下册第3次英语第4单元寒假试卷[含答案]
小学下册英语第4单元寒假试卷[含答案]考试时间:80分钟(总分:140)A卷一、综合题(共计100题共100分)1. 听力题:The ____ has a distinct waddle when it walks.2. 填空题:I enjoy spending time ______ during the holidays.3. 填空题:The flower is blooming in the ______.4. 填空题:The _______ (United Nations) was founded to promote peace and cooperation.5. 填空题:We have a ______ (学校) trip next week.6. 选择题:What do we call a person who studies weather patterns?a. Meteorologistb. Climatologistc. Atmospheric scientistd. Geologist答案:a7. 填空题:The walrus has long _______ (獠牙).8. 听力题:The _____ (house) is big.9. 听力题:The capital of Uzbekistan is __________.10. 填空题:I see many ______ (小动物) in the spring.11. 填空题:I like to __________ (动词) my __________ (玩具名) every day.12. 填空题:The _______ (Trail of Tears) was a forced relocation of Native Americans.13. 听力题:The chemical symbol for rubidium is ______.14. 听力题:My sister enjoys learning about ____ (science).15. 选择题:What is the capital of Nauru?a. Yarenb. Nauruc. Aiwod. Buada答案:a16. 填空题:I enjoy learning about different ______ (文化) around the world. It broadens my perspective and makes me more ______ (开放).17. 听力题:My dad is a ______. He enjoys woodworking.18. 选择题:What do you call the first meal of the day?A. LunchB. BreakfastC. DinnerD. Snack答案:B19. 填空题:I love to watch unboxing videos of ________ (玩具名) on the internet.20. 选择题:What is the capital city of Ghana?A. AccraB. KumasiC. TamaleD. Takoradi21. 听力题:The __________ can influence human activities and settlements.22. 选择题:What is the name of the famous landmark in New York City?A. Statue of LibertyB. Empire State BuildingC. Central ParkD. Brooklyn Bridge23. 选择题:Which fruit is red?A. BananaB. CherryC. OrangeD. Kiwi24. 选择题:What is the name of the famous clock tower in London?A. Big BenB. Eiffel TowerC. Leaning Tower of PisaD. Statue of Liberty答案:A25. 听力题:The chemical formula for ammonium chloride is ______.26. 选择题:What is 16 ÷ 4?A. 2B. 4C. 6D. 8答案:B27. 选择题:What is the capital of Egypt?A. CairoB. AlexandriaC. LuxorD. Giza答案:AThe country famous for its opera houses is ________ (澳大利亚).29. 填空题:I love my pet ______.30. 填空题:The fox is known for being ______ (狡猾).31. 选择题:What do we call the time when flowers bloom?A. WinterB. SpringC. SummerD. Fall32. 听力题:The Earth's surface is shaped by human and ______ activities.33. 填空题:The filmmaker produces amazing _____ (电影).34. 填空题:The armadillo has a tough _________ (外壳).35. 填空题:The ________ (水资源管理) is critical for sustainability.36. 听力题:The flowers are ________ and colorful.37. 选择题:What do you call the process of learning?A. EducationB. TrainingC. StudyD. All of the above答案:D38. 听力题:My mom loves to ________.39. 填空题:A ____(community-supported agriculture) connects consumers with farmers.I enjoy visiting the ______ (博物馆) to learn about history.41. 选择题:What is the hardest natural substance?A. GoldB. IronC. DiamondD. Silver42. 听力题:Astronomical units (AU) are used to measure distances within our ______.43. 选择题:What is 7 - 4?A. 1B. 2C. 3D. 444. 选择题:What is the name of the famous Egyptian structure built as a tomb?A. ColosseumB. Great WallC. PyramidD. Taj Mahal答案:C45. 填空题:In winter, the days are ______ (短暂的).46. 听力题:I like to ________ (explore) new places.47. 听力题:Her birthday is in ________.48. 填空题:The ______ (水分保持) is key for healthy plants.49. 填空题:A flamingo's diet consists mainly of ________________ (浮游生物).50. 填空题:My favorite _____ is a stuffed monkey.A rabbit has long ______ (耳朵) and a fluffy tail.52. 听力题:A chemical that can act as a reducing agent is called a ______.53. 选择题:What do we call a story that teaches a moral lesson?A. FableB. MythC. LegendD. Folklore答案: A54. 听力题:The car is _______ (red).55. 填空题:The ______ (生态系统) includes many interconnected parts.56. 选择题:What do we call a story that teaches a lesson?A. FableB. BiographyC. FictionD. Poem57. 选择题:Which of these is a cold-blooded animal?A. HumanB. SharkC. SnakeD. Bird答案:C58. 填空题:The __________ (历史的影响力) can drive social change.59. 听力题:A group of stars that form a pattern is called a ______.60. 选择题:What do you call the process by which plants absorb sunlight?A. PhotosynthesisB. RespirationC. FermentationD. Digestion61. 填空题:Canada has many ________ (加拿大有许多________) and lakes.62. 选择题:What do you call a place where you can borrow books?A. LibraryB. BookstoreC. SchoolD. Office63. 选择题:What is the capital of Bhutan?A. ThimphuB. ParoC. PunakhaD. Phuentsholing64. 填空题:I call my pet . (我称呼我的宠物为)65. 听力题:The bee gathers nectar from _______.66. 选择题:What do you call the solid form of water?A. IceB. SteamC. LiquidD. Vapor67. 填空题:The ________ (历史遗迹) tell stories of the past.68. 听力题:Metalloids have properties of both _____ and nonmetals.69. 选择题:What do we call the scientific study of rocks and minerals?A. BiologyB. GeographyC. GeologyD. Physics70. 选择题:Which of these is a vegetable?A. TomatoB. AppleC. BananaD. Grape71. 听力题:The Age of Exploration began in the _______ century.72. 听力题:A liquid that can dissolve other substances is called a ______.73. 听力题:We have a _____ (演出) next week.74. 听力题:The ____ lives in the wild and is very fast.75. 选择题:What is the opposite of ‘empty’?A. FullB. BareC. ClearD. Void76. 听力题:A _______ is used to measure the volume of liquids.77. 选择题:What do you call a young duck?A. DucklingB. ChickC. CalfD. Foal78. 听力题:The cat curls up on a _____ soft blanket.79. 填空题:My uncle is a __________. (程序员)80. 选择题:What is the capital of Japan?A. SeoulB. BeijingC. TokyoD. Bangkok81. 听力题:I have a ______ (new) bike.82. 选择题:What do we call the warmest season of the year?A. WinterB. SpringC. SummerD. Autumn83. 填空题:My cousin, ______ (我的表弟), is learning to skateboard.84. nature reserve) protects wildlife and habitats. 填空题:The ____85. 填空题:Every time I go to my friend’s house, we play with _________ (乐高).86. 填空题:The __________ (历史的解释) can vary among historians.87. 选择题:What do we call the practice of growing plants without soil?A. HydroponicsB. AeroponicsC. AquaponicsD. Soil farming答案: A88. 听力题:The process of liquid rock turning into solid rock is called ______.89. 填空题:I help my mom with __________. (整理)90. 填空题:The _______ (The Reformation) resulted in the establishment of Protestant churches.91. 填空题:The __________ (古代文明) left behind many archaeological sites.92. 选择题:What is the name of the famous artist known for his paintings of the American West?A. Georgia O'KeeffeB. Frederic RemingtonC. Thomas Hart BentonD. Grant Wood93. 选择题:What do we use to measure time?A. RulerB. ClockC. ScaleD. Compass94. 填空题:A _______ (海马) is a unique creature.95. 听力题:We are going to ___ a picnic. (have)96. 填空题:The __________ (温度的变化) can be harmful to sensitive plants.97. 填空题:The _____ (大象) uses its ears to cool off.98. 听力题:The chemical symbol for dubnium is _______.99. 选择题:What is the capital city of Mexico?A. CancunB. GuadalajaraC. Mexico CityD. Tijuana答案: C100. 填空题:The __________ (全球化) has changed how we view history.。
最近背单词的例句 romantic love is a il
最近背单词的例句romantic love is a il【1】Eliminating problems by transferring the blame to others is often called scape-goating.[1]用怪罪别人的办法来解决问题通常被称为寻找替罪羊。
【2】The chief foods eaten in any country depend largely on what grows best in its climate and soil.[2]一个国家的主要食物是什么,大体取决于什么作物在其天气和土壤条件下生长得最好。
【3】Over a very large number of trials, the probability of an event's occurring is equal to the probability that it will not occur.[3]在大量的实验中,某一事件发生的几率等于它不发生的几率。
【4】Most substance contract when they freeze so that the density of a substance ' s solid is higher than the density of its liquid.[4]大多数物质遇冷收缩,所以他们的密度在固态时高于液态。
【5】The mechanism by which brain cells store memories is not clearly understood.[5]大脑细胞储存记忆的机理并不为人明白。
【6】By the middle of the twentieth century, painters and sculptors in the United States had begun to exert a greatworldwide influence over art.[6]到了二十一世纪中叶,美国画家和雕塑家开始在世界范围内对艺术产生重大影响。
A Study of the Kalman Filter applied to Visual
2.1
Visual Tracking and the associated Problems
Hale Waihona Puke Visual tracking can be described as the process of determining the location of a feature in an image sequence over time. Examples include tracking cars in an intersection via a traffic camera, or tracking the head of a computer user with a web-cam. Another possible application is tracking multiple small features of interest, such as corners of an object, in attempt to determine its 3-dimensional geometry. The sequence of images can either be processed in real-time, coming directly from a video camera for example, or it can be performed on a recorded set of images. The implementation of this project uses recorded image sequences although the theory can be applied to both types of applications. The target to be tracked might be a complete object (e.g. a person) or a small area on an object (e.g. a corner). In either case, the feature of interest is typically contained within a target region. This project will consider a rectangular target region of arbitrary size. The position will be described in X-Y coordinates in pixel units on the image (i.e. 2
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Predicting Who Rated What in Large-scale DatasetsY an LiuIBM T.J.Watson Research Center Y orktown Heights,NY10598liuya@Zhenzhen Kou Department of Machine Learning Carnegie Mellon UniversityPittsburgh,P A15213 zkou@ABSTRACTKDD Cup2007focuses on movie rating behaviors.The goal of the task“Who Rated What”is to predict whether“ex-isting”users will review“existing”movies in the future.We cast the task as a link prediction problem and address it via a simple classification pared with other applications for link prediction,there are two major chal-lenges in our task:(1)the huge size of the Netflix data;(2) the prediction target is complicated by many factors,such as a general decrease of interest in old movies and more ten-dency to review more movies by Netflix users due to the success of the internet DVD rental industries.We address thefirst challenge by“selective”subsampling and the sec-ond by combining information from the review scores,movie contents and graph topology effectively1. Categories and Subject DescriptorsH.4[Information Systems Applications]:Miscellaneous KeywordsKDD Cup,Netflix,Link prediction1.INTRODUCTIONOne of the two tasks in KDD Cup2007is to predict which users rated which movies in2006,given the Netflix Prize training data set that contains more than100million ratings from over480thousand users on nearly18thousand movie titles collected between1998and2005.In our practice,we cast the task as a link prediction problem and address it via a simple classification approach.Link prediction,i.e.,the task of predicting the future struc-ture of a network given the current structure,is a funda-mental task in many data mining applications,such as so-cial network analysis,protein/genetic interaction prediction, and collaborativefiltering recommendation.Many models have been studied and applied to linkage -work evolution and graph generation models aim to capture how networks grow and change over time,typically based on the topological features[5;6;7].Network evolution and graph generation models focus on abstract graph wherePositiveNegativemean=129.273,std=78.260Figure 1:The histograms of proximity feature values from positive examples (left)and negative examples (right)year of 2005,it is more likely he or she will rate an anima-tion movie rather than a horror movie in 2006.We collect the movie content information,such as plot,director,actor,genre,movie connections from multiple sources on the inter-net.Then for each movie,we have its content information;for each user,we model the user’s preference with contents of movies that have been rated before.The raw content information that we collect from the inter-net is unstructured,resulting in a feature set of very high dimensions (over 50,000)when we convert them into struc-tured feature vectors using the bag-of-words representation.It raises a great challenge for any sophisticated classifica-tion models to be applied on a data set of extremely high dimensions in both the feature space and example space.Therefore we applied latent semantic indexing (LSI)[1]to obtain a low-dimensional feature representation:for each movie,we constructed one feature set based on directors,actors,genres and so on,and another feature set based on the plots of the movie.Then singular value decomposition (SVD)[2]is applied on the movie-content and movie-plot matrix respectively,and only the top 900singular vectors are kept for later uses.In this way,each movie is repre-sented with a relatively low-dimensional feature vector so that computing the similarity scores based on dot-product of movie vectors can be executed efficiently.For each example,i.e.,a pair of movie and user,we com-pute the proximity features in the following way:we use the dot product of two content feature vector to represent the similarity score of two movies.For each user,we retrieve the list of movies having been rated and call them user-related movies .Given an example,i.e.,a movie and a user,we compute all the similarity scores between this movie and the user-related movies,and then use the mean,minimum,and maximum scores as proximity features.To capture the user’s preference over time,we project the proximity fea-tures into three time ranges -the year of 2003,2004,and 2005.Figure 1shows an example of how the proximity fea-tures (a larger value mean indicates greater similarity)dis-criminate between positive and negative examples (different mean,variance as well as the shape of the plots).2.2Graph-based FeaturesAnother useful information source is the review history ofall users.A graph with users and movies as nodes can be constructed.Consider a graph G = V,E where each edge e = u,m ∈E represents an interaction between node u and m at a particular time t ,i.e.,user u rated movie m at time t .There is rich information contained in the graph.One of the most natural measurement for a node is how many other nodes it connects to.In our application,the connectivity represents how popular a movie is,or how active a user is,which is no doubt a meaningful factor in this problem.Therefore the features based on the number of connected edges are used.We also project such features into three time ranges -the year of 2003,2004,and 2005,to model the trend over time.Graph topology contains the most important set of features and can be applied to study on all networks.Recent studies on topological features have shown that shortest distance,clustering coefficient,number of common neighbors,and so on are extremely helpful for link prediction.Due to lim-ited time to work on the project,we implemented a set of naive features based on adjacency matrix.In the adjacency matrix,each row is a movie and each column represents a user.Therefore each movie can be represented with the cor-responding row in the adjacency matrix.Similarly to our proximity feature,SVD is first applied to convert the vector into a low-dimensional space,the similarity scores between a movie and the user-related movies are then computed,and finally the mean,minimum,and maximum scores are used as features.Figure 2shows an example of how the graph topology features discriminate between positive and nega-tive examples.3.EFFECTIVE SAMPLING APPROACHThe first step in data preparation is to collect all the data available.Therefore we combine the Netflix Prize training data and qualification set together as the “Netflix KDD”set.This results in 17,770movies and 480,189users,with 103,297,638reviews.As described on the KDD Cup website,the test sets are generated as follows:the 17770movies in the Netflix Prize training set were split randomly into two sets,one per task,resulting in 6822movies for “Who Rated What”task and 8863movies for “How Many Ratings”task.Let P(M 2006=i )=p i be the marginal probability that the i th movie is reviewed in 2006,and P(U 2006=j )=q j be the marginal probability that the j th user reviews a movie in 2006.The movie-user pair (x,y )in the testing set for “Who Rated What”task is generated as follows:x ∼P (M 2006),y ∼P (U 2006).If user y has reviewed movie x before 2006,the pair (x,y )is removed.Given the enormous data in the Netflix KDD set,sampling an effective training set is essential to apply any machine learning algorithms.On the other hand,since the goal is to predict the behaviors of existing users in existing movies,it is reasonable to explore similar behaviors in the previous years.Therefore following the sampling methodology as the test data,we generate two sample sets with around 100,000movie-user pairs for the year 2004and 2005as the training data,and two sample sets for the last quarter of year 2005as the development set.Notice that since we are only interested in the behaviors of existing users to existing movies,the pairs either with the users who joined after 2005(or 2004)Positivemean=8.914,std=11.3324Negativemean=13.204,std=20.819Figure 2:The histograms of graph-based feature values from positive examples (left)and negative examples (right)or with the movies which are released afterwards,need to be removed.We represent the resulting set as S-2005-1,S-2005-2,S-2004-1,S-2004-2,S-2005Q4-1,S-2005Q4-2respectively.The positive rate of the true labels in the sampled sets from different years is shown in Table 1.As we can see,the ratio remains similar over the years.In particular,the estimated rate in 2005is very close the one in the KDD Cup test set,which serves an excellent training set for our later prediction.200520067.94%7.80%2http://fi/MATLABArsenal/MATLABArsenal.htmthe research efforts on developing and evaluating classifica-tion algorithms on real-world data sets.In our experiments,we find that ridge regression and logistic regression are effi-cient and provide most accurate results.In our submission,we use the ridge regression since its optimization criterion agrees with the evaluation measure,i.e.root mean squared errors (RMSE).Ensemble of classifiers:In addition to the simple sin-gle classifiers,we also examine two ensemble approaches,including (1)building sub-classifiers on subsets of training examples to alleviate the problem of too many examples;and (2)building separate classifiers for each set of features (from the same sources)to reduce the dimension of the raw features.To combine the prediction of the sub-classifiers,we use the pre-set weights (by human)and the weights that are learned from the other development set.In our experi-ment,we find that the first ensemble approach,i.e.building classifiers on subsets of training examples,perform consis-tently worse than building a single classifier on the whole training set.Therefore,we focus on the second approach with different combination strategies.5.EXPERIMENT RESULTSIn this section,we describe the experiment results from two settings:one is the validation setting,which is used for fea-ture selection and classifier selection;the other is submission setting,which reports our final submitted results for KDD Cup 2007”Who Rated What”task.5.0.0.1Validation Results.In our validation experiments,we use S-2005Q4-1as the testing set,S-2005Q4-2as the development set and S-2005-1,S-2005-2,S-2004-1,S-2004-2as the training sets.The root mean squared error (RMSE)is used for evaluation measure.The results are shown in Figure 3.The RMSE of the baseline method,which is calculated by assigning all the examples as the prior of the test set,is 0.2394.From the results,we can see that:(1)all the methods achieve better results than the baseline method,which requires the nontrivial estimate of the prior of the positive examples in the test set;(2)the training sets from year 2005are much more effective than those from 2004;(3)the ensemble approach,which learns the weights from the development set using logistic regression,perform consistently the best.5.0.0.2Submission Results.For KDD cup 2007,we target at answering the question of “Who Rated What”in 2006.In the validation experiments,we have observed that the training sets sampled from the current year (compared with other years)are the most ef-fective for the predictions of the next year.Therefore we use the sets sampled from year 2005as the training data.In addition,to reduce the variance,we build two models using the two 2005sets,i.e.S-2005-1and S-2005-2respectively,and then average the predictions are with equal weights.Before the deadline of the submission,we generate the re-sults on the three models we have examined before but only submit the one generated by the single classifier (with ridge regression)using all the features in order to avoid possi-ble overfitting of the ensemble approach (whose weights are learned using S-2005Q4-2as the development set since weR M S E do of the。