Implementation and Analytical Model of Three-Phase Four-Switch Power Factor Corrector
双新课程改革的要求
双新课程改革的要求1.实施素质教育,提高学生综合素质。
Implementation of quality education to improve students' overall quality.2.推进课程国际化,培养国际视野。
Promote curriculum internationalization to cultivate an international perspective.3.强调跨学科学习,促进综合能力培养。
Emphasize interdisciplinary learning to promote comprehensive ability development.4.鼓励学生创新思维,培养创新能力。
Encourage students' innovative thinking and cultivate their innovation abilities.5.强化实践教学,提升实际操作能力。
Strengthen practical teaching to improve practical operational abilities.6.注重学生体验,提高学习动力。
Pay attention to student experience and improve learning motivation.7.关注学生发展,激发个性特长。
Pay attention to students' development and stimulate their individual strengths.8.强调学科融合,促进知识整合。
Emphasize subject integration to promote the integration of knowledge.9.实施个性化教学,满足不同学生需求。
Implement personalized teaching to meet the needs of different students.10.强化实践实训,提高就业竞争力。
工程经济学的含义 英语
工程经济学的含义英语The Significance of Engineering EconomicsEngineering economics is a crucial field of study that combines the principles of engineering and economic analysis to evaluate the feasibility and profitability of engineering projects. It provides a systematic approach to making informed decisions about the allocation of resources, the selection of alternative designs, and the optimization of project costs and benefits. In today's competitive business environment, engineering economics has become an indispensable tool for engineers, managers, and decision-makers who seek to maximize the value and efficiency of their engineering endeavors.At its core, engineering economics is concerned with the application of economic principles to the design, development, and implementation of engineering systems. This involves the analysis of various factors such as costs, revenues, risks, and time constraints to determine the most effective and efficient way to utilize resources and achieve desired outcomes. By employing quantitative and analytical techniques, engineering economists can assess the financial viability of a project, compare alternative solutions, andoptimize the use of materials, labor, and capital.One of the primary objectives of engineering economics is to ensure that engineering projects are not only technologically feasible but also financially sound. This requires a thorough understanding of the costs associated with various stages of a project, including initial capital investments, operating expenses, maintenance and repair costs, and potential revenue streams. By carefully analyzing these factors, engineering economists can develop accurate cost estimates, evaluate the overall economic impact of a project, and make informed decisions about the allocation of resources.In addition to cost considerations, engineering economics also addresses the time value of money and the impact of inflation on project costs and returns. This involves the use of techniques such as present value analysis, future value calculations, and discounted cash flow analysis to determine the optimal timing and sequencing of project activities. By incorporating these financial concepts into the decision-making process, engineers can better understand the long-term implications of their choices and make more informed decisions about project investments.Another key aspect of engineering economics is the evaluation of risk and uncertainty. Engineering projects often involve a wide range of variables and external factors that can influence their success orfailure. Engineering economists employ tools such as sensitivity analysis, Monte Carlo simulation, and decision trees to quantify and manage these risks, ensuring that project plans account for potential uncertainties and mitigate the impact of adverse events.The application of engineering economics extends across a wide range of industries and sectors, from manufacturing and construction to energy, transportation, and healthcare. In each of these domains, engineering economists play a crucial role in ensuring that engineering projects are not only technically sound but also financially viable and aligned with organizational goals and strategic priorities.For example, in the construction industry, engineering economists analyze the costs associated with different building materials, labor requirements, and project timelines to determine the most cost-effective approach to constructing a new facility. In the energy sector, they evaluate the economic feasibility of renewable energy projects, considering factors such as installation costs, maintenance expenses, and potential energy savings or revenue generation.Similarly, in the healthcare industry, engineering economists assess the financial impact of new medical technologies, equipment, and infrastructure investments, ensuring that hospitals and healthcare providers can maximize the value of their engineering investmentswhile providing high-quality patient care.In conclusion, the significance of engineering economics lies in its ability to bridge the gap between technical expertise and financial acumen. By integrating economic principles and analytical techniques into the engineering decision-making process, engineering economists help organizations optimize the use of resources, manage risks, and ensure the long-term sustainability and profitability of their engineering projects. As the complexity of engineering challenges continues to grow, the role of engineering economics will only become more critical in shaping the future of technological innovation and economic development.。
A Survey of Cyber-Physical Systems
A Survey of Cyber-Physical SystemsJiafu Wan a,ba School of Computer Science and EngineeringSouth China University of Technology,Guangzhou,Chinajiafuwan_76@Hehua Yan*,b,Hui Suo bb College of Information EngineeringGuangdong Jidian PolytechnicGuangzhou,China*Corresponding Author,hehua_yan@Abstract—Cyber Physical Systems(CPSs)are characterized by integrating computation and physical processes.The theories and applications of CPSs face the enormous challenges.The aim of this work is to provide a better understanding of this emerging multi-disciplinary methodology.First,the features of CPSs are described,and the research progresses are summarized from different perspectives such as energy control,secure control, transmission and management,control technique,system resource allocation,and model-based software design.Then three classic applications are given to show that the prospects of CPSs are engaging.Finally,the research challenges and some suggestions for future work are in brief outlined.Keywords-cyber physical systems(CPSs);communications; computation;controlI.I NTRODUCTIONCyber Physical Systems(CPSs)integrate the dynamics of the physical processes with those of the software and communication,providing abstractions and modeling,design, and analysis techniques for the integrated whole[1].The dynamics among computers,networking,and physical systems interact in ways that require fundamentally new design technologies.The technology depends on the multi-disciplines such as embedded systems,computers,communications,etc. and the software is embedded in devices whose principle mission is not computation alone,e.g.cars,medical devices, scientific instruments,and intelligent transportation systems[2]. Now the project for CPSs engages the related researchers very much.Since2006,the National Science Foundation(NSF)has awarded large amounts of funds to a research project for CPSs. Many universities and institutes(e.g.UCB,Vanderbilt, Memphis,Michigan,Notre Dame,Maryland,and General Motors Research and Development Center,etc.)join this research project[3,4].Besides these,the researchers from other countries have started to be aware of significance for CPSs research.In[5-7],the researchers are interested in this domain,including theoretical foundations,design and implementation,real-world applications,as well as education. As a whole,although the researchers have made some progress in modeling,control of energy and security,approach of software design,etc.the CPSs are just in an embryonic stage.The rest of this paper is outlined as follows.Section II introduces the features of CPSs.From different perspectives, the research processes are summarized in Section III.Section IV gives some classic applications.Section V outlines the research challenges and some suggestions for future work and Section VI concludes this paper.II.F EATURES OF CPS SGoals of CPSs research program are to deeply integrate physical and cyber design.The diagrammatic layout for CPSs is shown in Figure1.Obviously,CPSs are different from desktop computing,traditional embedded/real-time systems, today’s wireless sensor network(WSN),etc.and they have some defining characteristics as follows[7-10].∙Closely integrated.CPSs are the integrations of computation and physical processes.∙Cyber capability in every physical component and resource-constrained.The software is embedded inevery embedded system or physical component,andthe system resources such as computing,networkbandwidth,etc.are usually limited.∙Networked at multiple and extreme scales.CPSs,the networks of which include wired/wireless network,WLAN,Bluetooth,GSM,etc.are distributed systems.Moreover,the system scales and device categoriesappear to be highly varied.∙Complex at multiple temporal and spatial scales.In CPSs,the different component has probablyinequable Figure1.Diagrammatic layout for CPSsgranularity of time and spatiality,and CPSs are strictlyconstrained by spatiality and real time.∙Dynamically reorganizing/reconfiguring.CPSs as very complicated systems must have adaptive capabilities.∙High degrees of automation,control loops must close.CPSs are in favor of convenient man-machineinteraction,and the advanced feedback controltechnologies are widely applied to these systems.∙Operation must be dependable,certified in some cases.As a large scale/complicated system,the reliability andsecurity are necessary for CPSs.III.R EASEARCH P ROCESSSince2007,American government has treated CPSs as a new development strategy.Some researchers from various countries discussed the related concepts,technologies, applications and challenges during CPSweek and the international conference on CPS subject[11].The results of this research mainly concentrate in the following respects[7]. A.Energy ControlOne of the features of CPSs is distributed system.Though the vast majority of devices in CPSs need less energy,the energy supply is still a great challenge because the demand and supply of energy is inconvenient.In[12],a control strategy is proposed for realizing best trade-off between satisfying user requests and energy consumption in a data center.In[13-15],these papers concern the basic modeling of cyber-based physical energy systems.A novel cyber-based dynamic model is proposed in which a resulting mathematical model greatly depends on the cyber technologies supporting the physical system.F.M.Zhang et al [16]design optimal and adaptive discharge profile for a square wave impulsive current to achieve maximum battery life.J. Wei et al and C.J.Xue et al[17,18]develop an optimal lazy scheduler to manage services with minimum energy expenditure while not violating time-sensitive constraints.In [19],a peak inlet temperature minimization problem is formulated to improve the energy efficiency.J.R.Cao et al[20] present a clustering architecture in order to obtain good performance in energy efficiency.B.Secure ControlNow,the research for secure control mainly includes key management,identity authentication,etc.In[21],the existing security technologies for CPSs are summarized,and main challenges are proposed.C.Singh et al[22]explore the topic of the reliability assurance of CPSs and possibly stimulate more research in this area.T.T.Gamage et al[23]give a general theory of event compensation as an information flow security enforcement mechanism for CPSs.Then a case study is used to demonstrate this concept.In[24],a certifcateless signature scheme for mobile wireless CPSs is designed and validated.Y.Zhang et al[25]present an adaptive health monitoring and management system model that defines the fault diagnosis quality metrics and supports diagnosis requirement specifications.J.Wei et al[26]exploit message scheduling solutions to improve security quality of wireless networks for mission-critical cyber-physical applications.C.Transmission and ManagementCPSs need to conduct the transmission and management of multi-modal data generated by different sensor devices.In[27], a novel information-centric approach for timely,secure real-time data services in CPSs is proposed.In order to obtain the crucial data for optimal environment abstraction,L.H.Kong et al[28]study the spatio-temporal distribution of CPS nodes.H. Ahmadi et al[29]present an innovative congestion control mechanism for accurate estimation of spatio-temporal phenomena in wireless sensor networks performing monitoring applications.A dissertation on CPSs discusses the design, implementation,and evaluation of systems and algorithms that enable predictable and scalable real-time data services for CPS applications[30].Now,the exiting results are still rare,and there are many facets to be studied.D.Model-based Software DesignNow,the main model-based software design methods include Model Driven Development(MDD)(e.g.UML), Model-Integrated Computing(MIC),Domain-Specific Modeling(DSM),etc[31,32].An example,abstractions in the design flow for DSM,is shown in Figure2.These methods have been widely applied to the embedded system design[34, 35].On the basis of these,some researchers conduct model-based software design for CPSs in the following aspects:event model,physical model,reliability and real-time assurance,etc.Figure2.Abstractions in the design flow for DSM[33]1)Event model.E.A.Lee et al[36]make a case that the time is right to introduce temporal semantics into programming models for CPSs.A programming model called programming temporally-integrated distributed embedded systems(PTIDES) provides a coordination language rooted in discrete-event semantics,supported by a lightweight runtime framework and tools for verifying concurrent software components.In[37],a concept lattice-based event model for CPSs is proposed.This model not only captures the essential information about events in a distributed and heterogeneous environment,but it alsoPlatform mapping Abstractions are linkedthrough refinementrelationsAbstraction layers allowthe verification ofdifferent propertiesPlatform mappingAbstraction layersdefine platformsallows events to be composed across different boundaries of different components and devices within and among both cyber and physical domains.In addition,A CPS architecture along with a novel event model for CPS is developed[38].2)Physical model.In[39],a methodology for automatically abstracting models of CPSs is proposed.The models are described using a user-defined language inspired by assembly code.For mechanical systems,Y.Zhu et al[40]show how analytical models of a particular class of physical systems can be automatically mapped to executable simulation codes.S.Jha et al[41]present a new approach to assist designers by synthesizing the switching logic,given a partial system model, using a combination of fixpoint computation,numerical simulation,and machine learning.This technique quickly generates intuitive system models.3)Reliability and real-time assurance. E. A.Lee[42] emphasizes the importance of security,reliability and real-time assurance in CPSs,and considers the effective orchestration of software and physical processes requires semantic models. From the perspective of soft real-time and hard real-time,U. Kremer[43]conducts the research that the role of time in CPS applications has a fundamental impact on the design and requirements.In CPSs,the heterogeneity causes major challenges for compositional design of large-scale systems including fundamental problems caused by network uncertainties,such as time-varying delay,jitter,data rate limitations,packet loss and others.To address these implementation uncertainties,X.Koutsoukos et al[44]propose a passive control architecture.For improving reliability,T.L. Crenshaw et al[45]describe a simplex reference model to assist developers with CPS architectures which limit fault-propagation.A highly configurable and reusable middleware framework for real-time hybrid testing is provided in[46].Though the model-based software design has an early start, the present development of CPSs progresses at a fast enough rate to provide a competitive challenge.E.Control TechniqueCompared with other control applications,the control technique for CPSs is still at an elementary stage.F.M.Zhang et al[2]develop theoretical results in designing scheduling algorithms for control applications of CPS to achieve balances among robustness,schedulability and power consumption. Moreover,an inverted pendulum as a study object is designed to validate the proposed theory.N.Kottenstette et al[47] describe a general technique:passivity and a particular controller structure involving the resilient power junction.In [48],a design and implementation of CPSs for neutrally controlled artificial legs is proposed.In[49],J.L.Ny et al approach the problem of certifying a digital controller implementation from an input-output,robust control perspective.F.System Resource AllocationUntil now,the relative research for system resource allocation mainly focuses on embedded/real-time systems, networked control systems,WSN,etc[50-52].Towards the complicated CPSs,this work is in the beginning stage.V.Liberatore[53]gives a new train of thought on bandwidth allocation in CPSs.In[54],the model dynamics are presented to express the properties of both software and hardware of CPSs,which is used to do resource allocation.K.W.Li et al [55]research the problem of designing a distributed algorithm for joint optimal congestion control and channel assignment in the multi-radio multi-channel networks for CPSs.The ductility metric is developed to characterize the overload behavior of mixed-criticality CPSs in[56].IV.C LASSIC A PPLICATIONSApplications of CPSs include medical devices and systems, assisted living,traffic control and safety,advanced automotive systems,process control,energy conservation,environmental control avionics and aviation software,instrumentation,critical infrastructure(e.g.power,water),distributed robotics,weapons systems,manufacturing,distributed sensing command and control,smart structures,biosystems,communications systems, etc.[9,10].The classic application architecture of CPSs is described in[38].Now,some application cases for CPSs have been conducted in[57-64].Here,three examples(Health Care and Medicine,Intelligent Road and Unmanned Vehicle,and Electric Power Grid)are used to illuminate the classic applications of CPSs[8,9].A.Health Care and MedicineThe domain of health care and medicine includes national health information network,electronic patient record initiative, home care,operating room,etc.some of which are increasingly controlled by computer systems with hardware and software components,and are real-time systems with safety and timing requirements.A case of CPSs,an operating room,is shown in Figure3.Figure3.A case of CPSs:An operating room[8,9]B.Electric Power GridThe power electronics,power grid,and embedded control software form a CPS,whose design is heavily influenced by fault tolerance,security,decentralized control,and economic/ ethical social aspects[65].In[8,9],a case of CPSs,electric power grid,is given as shown in Figure4.Figure4.A case of CPSs:Electric power grid[8,9]C.Integrate Intelligent Road with Unmanned VehicleWith the development of sensor network,embedded systems,etc.some new solutions can be applied to unmanned vehicle.We are conducting a program that intelligent road and unmanned vehicle are integrated in the form of CPSs.Figure5 shows another case of CPSs:Integrate intelligent road with unmanned vehicle.Figure5.A case of CPSs:Integrate intelligent road with unmanned vehicleV.R ESEARCH C HALLENGESCPSs as a very active research field,a variety of questions need to be solved,at different layers of the architecture and from different aspects of systems design,to trigger and to ease the integration of the physical and cyber worlds[66].In[10, 42,66-68],the research challenges are mainly summarized as follows:1)Control and hybrid systems.A new mathematical theory must merge event-based systems with time-based systems for feedback control.This theory also must be suitable for hierarchies involving asynchronous dynamics at different time scales and geographic scope.2)Sensor and mobile networks.In practical applications, the need for increased system autonomy requires self-organizing/reorganizing mobile networks for CPSs.Gathering and refining critical information from the vast amount of raw data is essential.3)Robustness,reliability,safety,and security.It is a critical challenge because uncertainty in the environment,security attacks,and errors in physical devices make ensuring overall system robustness,security,and safety.Exploiting the physical nature of CPS by leveraging location-based,time-based and tag-based mechanisms is to realize security solutions.4)Abstractions.This aspect includes real-time embedded systems abstractions and computational abstractions,which needs new resource allocation scheme to ensure that fault tolerance,scalability,optimization,etc.are achieved.New distributed real-time computing and real-time group communication methods are needed.In addition,the physical properties also should be captured by programming abstractions.5)Model-based development.Though there several existing model-based development methods,they are far from meeting demands in puting and communications,and physical dynamics must be abstracted and modeled at different levels of scale,locality,and time granularity.6)Verification,validation,and certification.The interaction between formal methods and testing needs to be established. We should apply the heterogeneous nature of CPS models to compositional verification and testing methods.VI.C ONCLUSIONSIn the last few years,this emerging domain for CPSs has been attracting the significant interest,and will continue for the years to come.In spite of rapid evolution,we are still facing new difficulties and severe challenges.In this literature, we concisely review the existing research results that involve energy control,secure control,model-based software design transmission and management,control technique,etc.On this basis,some classic applications used to show the good prospects.Then,we propose several research issues and encourage more insight into this new field.A CKNOWLEDGMENTThe authors would like to thank the National Natural Science Foundation of China(No.50875090,50905063), National863Project(No.2009AA4Z111),Key Science and Technology Program of Guangdong Province(No. 2010B010700015),China Postdoctoral Science Foundation (No.20090460769)and Open Foundation of Guangdong Key Laboratoryof Modern Manufacturing Technology(No. GAMTK201002)for their support in this research.R EFERENCES[1]Available at:/cps/.[2] F.M.Zhang,K.Szwaykowska,W.Wolf,and V.Mooney,“Taskscheduling for control oriented requirements for Cyber-Physical Systems,”in Proc.of2008Real-Time Systems Symposium,2005,pp.47-56.[3]Available at:/news/17248-nsf-funds-cyber-physical-systems-project/.[4]J.Sprinkle,U.Arizona,and S.S.Sastry,“CHESS:Building a Cyber-Physical Agenda on solid foundations,”Presentation Report,Apr2008.[5]Available at:/.[6]Available at:/gdcps.html.[7]J.Z.Li,H.Gao,and B.Yu,“Concepts,features,challenges,andresearch progresses of CPSs,”Development Report of China Computer Science in2009,pp.1-17.[8]R.Rajkumar,“CPS briefing,”Carnegie Mellon University,May2007.[9] B.H.Krogh,“Cyber Physical Systems:the need for new models anddesign paradigms,”Presentation Report,Carnegie Mellon University. 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精英英语学习计划大学生
精英英语学习计划大学生IntroductionEnglish has become the most widely spoken language in the world, and its importance in the fields of education, business, and communication cannot be overstated. For college students, mastering the English language is crucial for success in academics, career, and personal growth. However, many students struggle to achieve fluency and proficiency in English due to various reasons, such as lack of effective learning strategies, limited practice opportunities, and insufficient motivation. In this elite English learning plan, we will outline a comprehensive and systematic approach to help college students improve their English skills and achieve excellence in the language.Goals of the Elite English Learning Plan1. To enhance college s tudents’ proficiency in English speaking, listening, reading, and writing.2. To cultivate a deep understanding of English grammar, vocabulary, and idiomatic expressions.3. To develop critical thinking and analytical skills through engaging with English literature and academic texts.4. To build confidence and fluency in public speaking and oral presentations in English.5. To provide opportunities for immersive language practice and cultural exchange through various activities and programs.Components of the Elite English Learning Plan1. Language Skills Improvementa. Speaking and Listening- Participate in English conversation clubs and language exchange events.- Watch English movies, TV shows, and listen to English podcasts to improve listening comprehension.- Practice pronunciation and intonation through speech exercises and language drills.- Engage in group discussions and debates on a wide range of topics in English.b. Reading and Writing- Read English literature, journalism, and academic texts in various genres and styles.- Analyze and critique English writings to improve comprehension and critical thinking skills.- Practice writing essays, articles, and creative pieces in English with feedback from peers and instructors.- Expand vocabulary through reading and learning new words in context.2. Grammar and Vocabulary Enrichmenta. Study English grammar rules and sentence structures in depth.b. Memorize and practice using new vocabulary and idiomatic expressions in everyday conversations and writing.c. Take regular quizzes and tests to assess and reinforce grammar and vocabulary knowledge.3. Academic and Scholarly Engagementa. Attend English language workshops and seminars to gain insights into academic writing and research skills in English.b. Engage with English literature, philosophy, and social sciences to broaden intellectual horizons and enhance language proficiency.c. Write research papers and presentations in English to develop academic writing skills.4. Public Speaking and Presentation Skillsa. Prepare and deliver presentations on various topics in English.b. Engage in public speaking competitions and workshops to build confidence and fluency in English communication.c. Receive constructive feedback and coaching on improving public speaking and presentation skills.5. Immersive Language Practice and Cultural Exchangea. Participate in study abroad programs or language immersion experiences in English-speaking countries.b. Engage in language exchange with native English speakers or international students.c. Join cultural events, festivals, and activities to experience English-speaking cultures firsthand.Implementation and EvaluationThe elite English learning plan will be implemented through a combination of classroom instruction, interactive workshops, language immersion experiences, and extracurricular activities. Students will receive regular feedback and assessment on their language skills and progress, and personalized guidance will be provided to address individual learning needs and goals.Benefits of the Elite English Learning Plan1. Improved academic performance in English language courses and related disciplines.2. Enhanced communication and interpersonal skills in English for future career opportunities.3. Expanded cultural awareness and global perspective through language and cultural exchange.4. Development of critical thinking and analytical skills through engaging with English literature and academic texts.5. Increased confidence and fluency in public speaking and presentation skills. ConclusionThe elite English learning plan for college students aims to provide a holistic and systematic approach to English language improvement, with a focus on individualized learning and experiential opportunities. Through this plan, students will be equipped with the necessary language skills, cultural knowledge, and critical thinking abilities to excel in their academic, professional, and personal pursuits. With dedication and commitment, college students can achieve fluency and excellence in the English language and become global citizens of the21st century.。
Research_on_Interactive_Model_of_Curriculum_Standa
Theory and Practice of Science and Technology2022, VOL. 3, NO. 6, 118-122DOI: 10.47297/taposatWSP2633-456919.20220306Research on Interactive Model of Curriculum Standards Implementation -- Taking Java Programming as an Example Guohua XiongGuangdong Construction Polytechnic, Guangzhou Guangdong 510440, ChinaABSTRACTIn order to improve the teaching quality of software technology specialty,this paper first analyzes the foreign interactive teaching model,reconstructs the theoretical analysis framework for teachers to implementcurriculum standards, summarizes the core indicators for teachers toimplement curriculum standards and designs a suitable curriculumstandard implementation model, and verifies the rationality of the modelwith the implementation of the curriculum standard of JavaProgramming as an example, Through the joint implementation ofteachers and students, the results show that the model can effectivelyimprove students' learning interest and practical ability, and can provide atheoretical basis for promoting teachers' professional development in thenew curriculum and teaching reform.KEYWORDSCurriculum standard; Interactive model; Teaching implementation; JavaProgramming1 IntroductionThe implementation of curriculum standards carries educational ideas, is a professional and practical work, and has complex value orientation. How to effectively implement curriculum standards and promote teacher professionalization is the key to the realization of curriculum teaching design. The implementation of curriculum standards has always been put in a prominent position in the curriculum reform research of all countries in the world. How to inspire teachers to think about the implementation process of curriculum standards "like experts" as a whole [1], pay attention to students' learning and growth, and form a good teacher-student interaction has become a hot research issue for educators.2 Research Status(1) Research status abroadForeign scholars pay attention to the study of the interaction between teachers and curriculum, and the representative researchers are Remilard, Drake, etc. They are mainly based on teachers' empirical research to understand the interaction between teachers and curriculum, and use this as an analytical framework to solve the problem of teachers' implementation of curriculum standards. They regard the development of theoretical models as an important part of the implementation of curriculum standards, and the number of models constructed is complex. From the perspective of research, the model can be divided into two categories. One is the model of teachers' curriculumTheory and Practice of Science and Technology implementation, such as the famous "Concern-based adoption model (CBAM)"; The other is the interactive model for the implementation of curriculum standards, such as the curriculum hierarchy theory created by Goodlad in the early stage, and the "teacher student content" interactive model developed by Anderson on the basis of this theory.(2) Domestic research statusThe research in China is relatively late. The research on teachers' implementation of curriculum standards mainly focuses on the implementation level, influencing factors and effectiveness. It is difficult to explore the development context of the implementation of curriculum standards, and the theoretical depth is not enough. Although the theoretical research on the implementation of curriculum standards by teachers has been continuing in recent years, it is still in the exploration period, and there is no systematic theory of curriculum implementation. Some domestic scholars equate the implementation of curriculum standards with teaching, and "curriculum" is regarded as teaching materials. The implementation of curriculum standards is to implement the content of teaching materials; Another part of scholars believe that the implementation of curriculum standards is the process of putting innovative curriculum plans into practice [2].3 Research IdeasBy comparing the research on the implementation of curriculum standards by teachers at home and abroad, it is found that there are some typical models for the implementation of curriculum standards by foreign teachers, and they have developed in depth; However, in China, there are either speculative discussions or direct practical explorations, and there are few theoretical systems for teachers to implement curriculum standards. In view of this, the research idea of this paper is to reconstruct the theoretical analysis framework of teachers' implementation of curriculum standards through the theoretical analysis of foreign typical models, and on this basis, summarize the key issues of teachers' implementation of curriculum standards and design a suitable curriculum standard implementation model, and take the implementation of Java Programming curriculum standards as an example to verify the rationality of the model, At the same time, the consistency of teaching evaluation in the implementation of curriculum standards by teachers is analyzed, and thespecific ideas are shown in Figure 1.Figure 1 Research ideas 119Guohua Xiong 1204 Construction of Interactive Model for Curriculum Standard Implementation (1) Concept of interactive teaching modeThe literature [3]believes that the interactive teaching mode refers to the teaching principle of "students as the main body and teachers as the leading role", which focuses on heuristic teaching and allows students and teachers to participate in the teaching and learning of the course. Literature [4] believes that it is a teaching structure model aimed at cultivating students' independent consciousness and innovation ability, and at "making students love, learn and be good at learning". This paper believes that the interactive teaching mode refers to the teaching mode that, under the guidance of the teaching ideology of "students as the main body, teachers as the leading, and training projects as the main line", around the training projects, interactive teaching methods, supplemented by heuristic methods, let teachers and students participate in the bilateral activities of training project teaching and learning, so as to achieve the goal of cultivating students' innovative spirit and improving practical ability.(2) Relevant theoretical basisAt present, the relevant theories of interactive teaching research mainly focus on constructivism and humanism.Constructivism is one of the most influential educational concepts in the world today. It puts forward a series of new explanations for learning and teaching. It believes that learning is carried out under specific social and cultural background and specific learning environment conditions. When designing practical projects, combining the actual situation of real life is conducive to stimulating students' interest and overcoming the abstraction of learning content To enable students to fully use their knowledge and experience in their cognitive structure, give play to their association and imagination, and promote the effective transfer of students' knowledge [5] [6]. The essence of constructivism is to analyze the nature of cognitive activities and put forward a new understanding of the construction process of learning. Constructivism regards students as the subject and center of the teaching process, attaches importance to the role of students' existing knowledge and experience and psychological structure, attaches importance to the subjective initiative of students' learning process, emphasizes the social and situational nature of students' learning, and believes that teachers should play the role of organizers, helpers and promoters in the teaching process, reflecting the student-oriented teaching concept.Humanism education theory mainly emphasizes the teaching goal view of knowing and unifying, the meaningful free learning view and the student-centered teaching view. Its emphasis is not on the teaching results but on the teaching process, emphasizing the development of students' potential, personality and creativity in the process; What we pay attention to is not the teaching content but the teaching method. In the teaching method, we advocate student-centered, everything for the development of students, and let students choose and discover themselves.(3) Curriculum standard interactive model designSince the teaching of the curriculum follows the corresponding curriculum standards, a better interactive curriculum standard is, to a certain extent, the prerequisite for achieving high-quality curriculum interaction. For another course, from the beginning to the end of the course assessment, the interaction between teachers and students is permeated in the whole teaching process, so we divide the design of interactive curriculum standards into three stages.The first stage is to interact before class and formulate curriculum standards. Before each class,Theory and Practice of Science and Technology the teacher requires the students to preview. Before class, the teacher should explain the teaching objectives, key and difficult points of the course, relevant requirements of practical training and scoring standards to the students. Then, through questionnaires, group discussions, network tool interaction and other methods, master the students' preview situation and basic needs for the course content, and carry out pre-class learning situation analysis based on this, and then modify or redesign in combination with the original curriculum standard to develop a new curriculum standard. Take part of the contents of Chapter 2 Java Programming Basics of Java Programming for example, as shown in Table 1. Since students have learned C Content Language Programming before learning this course, they use the form of pre-class questionnaire to achieve the purpose of interaction. This can clarify what content students can learn by themselves, what content needs to be taught and what kind of teaching method students can accept more easily. Based on this, the curriculum standard of this course can be preliminarily designed.The second stage is interaction in class and adjustment of curriculum standards. During the course of teaching according to the preliminarily designed curriculum standard, analyze whether the students' mastery of knowledge is consistent with the pre-class analysis according to the students' actual training completion and the students' performance in the discussion link. During the course of teaching, students may also put forward some new questions. At this time, the teacher should make a good record and analysis of the learning situation in class, and modify the preliminarily implemented curriculum standard after class according to the analysis. Java Program Design is a practical course, which uses students to achieve the organic integration of theoretical knowledge and practical skills. The course selection is based on project-based teaching. In class, teachers and students jointly discuss the needs analysis of the project. The key technology realization is explained by teachers in the way of theoretical teaching and practical demonstration, and then by students on the computer, To reflect the student-centered concept, students can also design and complete independently.The third stage is after-class interaction and optimization of curriculum standards. After class, teachers should not only organize students to investigate the teaching satisfaction of this class, but also ask students to put forward good practices and problems that need to be improved, and analyze students' mastery of the knowledge of this class according to the completion of homework after class, so as to further optimize the curriculum standards of this class.Through the above theoretical analysis, the designed interactive model for the implementation of curriculum standards is shown in Figure 2.Table 1 Analysis of basic knowledge points of Java programmingKnowledge PointsBasic format of Java programComments in JavaIdentifier in JavaKeywords in JavaConstants in JavaDefinition of variablesData type of variableType conversion of variableScope of variableArithmetic operatorAssignment OperatorsComparison operatorLogical operatorOperator precedence Self-study or not √√√√√√√Key Lectures √√√√√√√Teaching Method Lecture and Demonstration Lecture and Demonstration Lecture and Demonstration Lecture and Demonstration Lecture and Demonstration Lecture and DemonstrationLecture and Demonstration 121Guohua Xiong 5 ConclusionAt present, there is still a lack of research on the interactive model of curriculum standard implementation, and even less empirical research and specific teaching practice are involved. Starting from this weak link, this paper comprehensively introduces the concept, basis and process of the establishment of interactive curriculum standards in three stages of pre-class, in-class and post-class, and accordingly designs an interactive model for the implementation of curriculum standards, and validates the model through the implementation of the curriculum standard Java Programming. The results of the validation not only deepen the teachers' understanding of the implementation process of curriculum standards to a certain extent, More importantly, it can provide some theoretical basis for promoting teachers' professional development in the new curriculum and teaching reform, and provide a framework for reference and analysis for improving teachers' professional practice.FundingThis paper is Supported by Educational Planning Project of Guangdong Province in 2021 (Grant No. 2021GXJK534), Supported by Project of China Construction Education Association in 2021 (Grant No.2021177), Supported by Science and Technology Innovation Strategy Special Project in Guangdong Province in 2022 (Grant No.pdjh2022b0834), Supported by universities characteristic innovation project of Guangdong Province in 2022 (Grant No. 2022KTSCX248), Supported by School level project of Guangdong Construction Polytechnic in 2021 (Grant No.JG2021-12).References[1] Research on the interactive model of teachers'implementation of curriculum standards[D].Yangtze University,2020.[2] XIA Xuemei,CUI Yunhuo.Interaction Perspective of Teachers'Curriculum Implementation:A Construction Based on Literature Review of 40 Years[J]. Research in Educational Development,2013,33(24):1-5+10.[3] Zhao Liqun. The Research and Practice of Interactive Pattern in Class between the Teacher and Students[D]. Liaoning Normal University,2006.[4] Li Ment. Instructional Pattern Construction and Practice Research of the Synchronous Interactive Class[D]. Central China Normal University,2015.[5] ZHANG Zhiliang, WANG Meng, LI Hui. Research on experimental teaching based on constructivism learning theory[J]. Laboratory Science. 2022,25(04):93-96.[6] Zhang Sai.Integrating Innovation Education into Professional Education Practice Based on Anchoring Teaching Model:Taking Changjiang Polytechnic as an Example[J]. Journal of Hubei Adult Education Institute. 2022,28(03):62-66.Figure 2 Interactive model of curriculum standard implementation 122。
二苯乙烯光致顺反异构化反应
研究论文Article* E-mail: cyzhu@.twReceived April 21, 2012; published August 6, 2012.Project supported by the National Natural Science Foundation of China (Nos. 21003100, 21033001, 21103136, 21173166. 项目受国家自然科学基金(Nos. 21003100, 21033001, 21103136, 21173166资助.化学学报ACTA CHIMICA SINICA改进的半经典动力学模拟二苯乙烯光致顺反异构化反应雷依波a ,b 朱超原*,b 文振翼a,b 林聖聖b(a 合成与天然功能分子化学教育部重点实验室西北大学化学与材料科学学院西安 710069(b 西北大学现代物理研究所西安 710069摘要发展了一种改进的半经典动力学模拟方法, 并将其程序化用于气相二苯乙烯光致顺反异构化反应的机理研究. 新的方法不仅采用e 指数模型改进了原有Zhu-Nakamura 理论中计算电子非绝热跃迁几率的计算方法, 而且将约束哈密顿方法用于限制性分子动力学模拟过程中. 计算结果表明, 采用此方法得到的统计平均的量子产率及反应机理与以前的实验与理论结果吻合较好, 从而可以应用于全量子动力学方法无法进行的大分子体系的动力学研究. 关键词改进的半经典动力学模拟; 约束哈密顿系统; Zhu-Nakamura 理论; 二苯乙烯顺反异构化; 二维解析势能面New Implementation of Semi-classical Dynamic Simulation on the Photoisomerization of cis- and trans-Isomers of Free StilbeneLei, Yibo a ,b Zhu, Chaoyuan *,b Wen, Zhenyi a ,b Lin, Sheng-Hsien b(a Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education , The College of Chemis-try & Materials Science , Shaanxi Key Laboratory of Physico-Inorganic Chemistry , Northwest University , Xi'an 710069(b Institute of Modern Physics , Northwest University , Xi'an 710069 Abstract New implementation of semi-classical trajectory surface hopping dynamic simulation has been developed and applied to the photoisomerization of cis- and trans- isomers on the gas phase. This method not only uses the exponential model to the modification of the originally analytical non-adiabatic transition probability formula, but also involves the con-strained Hamiltonian system into the constrained molecular dynamic simulation. Two-dimensional potential energy surfaces of ground S 0 and excited S 1 states are constructed analytically fitting to ab initio calculations in terms of torsion angle and one dihedral angle around the central ethylenic C =C bond as variables, and the other internal coordinates are all fixed at configuration of one-bond flip conical intersection. The analytical PESs are quite accurate and the mean abs olute error is less than 2.4 kcal •mol -1, and much less than 1.0 kcal •mol -1 around conical intersection region. A straight seam line is found on potential energy surfaces that simply separates the cis-area with the trans-area. The constrained Hamiltonian system is em-ployed to run trajectories in the Cartesian coordinate system and surface hopping in terms of the two internal dihedral angles. Typical trajectories are found in which the torsion angle changes monotonically for both cis- to trans- and trans- to cis- isomerizations. This is an exact picture of one-bond flip mechanism of photoisomerization around the conical intersection. Quantum yield for trans- to cis- isomerization is simulated as 60.45% in very good agreement with experimental value 55.0%, while quantum yield for cis- to trans- isomerization is simulated as 42.3% in comparison with experimental value 35.0%. As the S 1 energy inlocal minimum of cis-area is higher than that in trans-area, and thus cis- to trans- isomerization is quite possible to access to another Hula-Twist conical intersection. These simulation results demonstrate that the computed cumulative quantum yield and reaction mechanism are consistent with the previously experimental and theoretical results. This means that the present trajectory surface hopping method would be good at the dynamic simulation on the large system with or without constraint Hamiltonian in comparison with the quantum molecular dynamics.Keywords new implementation of semi-classical dynamic simulation; constrained Hamiltonian system; Zhu-Nakamura theory; isomerization of cis- and trans-stilbene; two dimensional analytical potential energy surfaces1 引言众所周知, 二苯乙烯在光照下可以从其顺式构型转变为反式构型, 也可以从反式结构异构化到顺式结构, 其中反式二苯乙烯分子构型示于图 1. 反应过程中电子首先受光照从基态激发到激发态, 再经过无辐射跃迁回到分子基态. 一般情况下, 电子跃迁主要集中在第一激发态S 1和基态S 0之间[1], 其中S 1对应电子从S 0的最高占据分子轨道(HOMO到最低未占据轨道(LUMO的跃迁.大量的实验数据表明光照下二苯乙烯从顺式转换到反式和从反式到顺式的量子产率分别约为35%和55%(或52%[2~5], 其中顺式到反式产率较低的原因是有DOI: 10.6023/A1204013910%的顺式二苯乙烯经过环化反应生成一个副产物4a, 4b-二氢菲(DHP[6~8]. 理论分析认为反应过程很有可能经过一个能量相对较低的圆锥相交点(标记为OBF-CI[1], 当受激反应物靠近此相交点时, 电子就从激发态跃迁到达产物或者返回到基态. 此前的理论和实验报道倾向于反应坐标主要由苯环及氢原子绕着中心乙烯双键的旋转所决定[9], 具体对应图1中的两个二面角D1和D2. 而Fu β等认为此顺反异构化过程中还应该考虑苯环自身转动的影响, 此结论得到了一些实验的证实[10~12]. 以上这些反应机理大多数只是依靠对圆锥相交点的分析. 为了更好地研究反应的动力学过程, 豆育升及其合作者通过实时激光诱导的动力学模拟对反应机理进行了研究, 模拟结果证实反应过程中描述苯环或氢原子绕中心烯键扭转的二面角的变化较大, 而苯环自身转动的二面角的变化较小[13]. 此动力学模拟过程中只考察了一个典型反应轨迹的运动, 没有考虑动力学中的相效应, 因此无法得到反应的统计平均的量子产率. 另外一维和两维的势能面也被构建用于研究反应的机理, 但其中有些势能面只考虑苯环绕中心烯键扭转[14]; 有些通过实验数据拟合得到[15]; 有些势能面虽然通过从头算方法计算得到, 但所选反应坐标非独立坐标, 无法用于动力学研究[1].图1 反式二苯乙烯的几何构型图Figure 1 Structure and standard numbering of trans-stilbene鉴于此, 本文首先采用态平均多组态的自洽场方法(SA-CASSCF在6-31G 的基组水平上构建新的二维势能面[16,17], 所选独立变量为图1所述二面角D1和D2的线性组合二面角DD1和DD2. 其中DD1为D1和D2的平均值(D2+D1/2; DD2表示D2相对D1的扭转大小, 即(D2-D1/2. 为了简化计算量, 我们拟合了势能面的解析表达式, 并用于提供经典轨迹中原子核运动所需的力. 由于此分子体系较大, 无法构建3N -6维的全维势能面(其中N 为原子数, 因此本文采用约束Hamilton 系统限制部分核坐标的运动, 例如在动力学模拟过程中每个苯环将始终作为一个刚体运动. 在此基础上将最新改进的Trajectory Surface Hopping (TSH方法用于半经典动力学模拟二苯乙烯的光致顺反异构化过程中. TSH 方法由Tully 和Preston [18]首先提出, 其基本思想是反应轨迹总是在单一势能面上演化, 电子的非绝热跃迁几率可以由Laudau-Zener 公式或数值求解含时耦合方程得到. 20世纪90年代, 朱超原与Nakamura 共同提出的Zhu-Nakamura 理论简化了非绝热跃迁几率的计算[19~25]. 此理论分别采用Landau-Zener 和nonadiabatic tunneling 两种模型推出两种类型的几率计算公式[19,20]. 采用哪一种模型取决于非绝热区两个电子态的势能的梯度的符号是否相同, 前者对应同向, 后者对应反向, 因此在计算跃迁几率时需要首先确定势能面的类型. 最近, 我们基于此理论进一步采用e 指数模型推出了非绝热跃迁几率的新公式, 避免了预先确定势能面类型的工作. 下面将简要介绍新的计算方法和程序化过程, 并详细报道基于此方法所做的动力学模拟的结果与讨论.2 理论背景如前所述, TSH 方法中核运动采用约束Hamilton 系统进行经典计算, 而电子是否发生无辐射跃迁取决于非绝热跃迁几率的大小. 下面我们简要介绍一下这两部分内容的理论背景. 2.1 约束系统Hamilton约束系统Hamilton 量:23(,,((2CN Ni k k i ki p H q p V q g q m λλ∑∑=++(1应该满足约束条件(0k g q =(2从而保持体系能量守恒. 此Hamilton 系统所对应的正则方程可以描述为[26~29]: (,,i i ii p H q p q p m λ∂∂ == (3((,,(C N uc cki i i k ki i i g q H q p V q p f f q q q λλ∂∂∂∂∂∂∑ =-=+=--(4 其中m i , q i 和p i 分别对应原子i 的质量、坐标和动量. g k (q 和λk (t 分别对应第k 个约束条件(包括键长、键角和二面角约束及所对应的拉格朗日乘子. 式(4中uc i f 所对应的是体系势场所提供的力, 而c i f 是用来约束核运动的力, 其贡献来自于约束方程关于核坐标的微分(/k i g q q ∂∂. 我们采用拉格朗日乘子法求解满足约束方程式(2的λk (t . 首先确定t 时刻的核坐标及动量, 然后数值积分式(3得到t +Δt 时刻的坐标[27]1212(((((((Cuc c i i i i N uc k i i kkiq t t q t t m t f t g q q t t m t q λ−−ΔΔΔ∂ΔΔ∂∑+=++=+- (5其中(uc i q t t Δ+是t +Δt 时刻未受约束的核坐标. 将q i (t +Δt 带入式(2从而构造包括键长、键角和二面角约束的非线性方程组. 求解这些关于λk (t 的非线性方程组需要采用Powell’s Dog Leg 方法[30]. 此方法通过如下公式00(||k k g J g λλλ===-(6逐步更新λk , 直至2-范数k g 小于预先设定的阈值τ. 其中J g 为约束方程g k (q 所对应的雅克比矩阵. 此方法已经收录在免费程序包MINPACK [31,32]中, 只需将预先得到的g k (q 和J g 输入此程序中即可得到所需求解的λk (t . 将其代入式(3和(4应用数值积分方法四阶龙格-库塔方法(RK4[33,34], 即可求解t +Δt 时刻体系的约束坐标及动量. 将此作为起始可以得到经过下一个时间步长Δt 后体系的坐标及动量. 这样沿着固定时间步长数值运算核坐标及其动量时间的过程对应体系的动力学模拟过程. 2.2 非绝热跃迁几率在一维透热模型的势能曲线上, 体系的无辐射跃迁与两个参数有关, 分别是有效耦合常数a 2和有效碰撞能b 2 [24]. 它们分别表示为:22213(28xF F F a m V =-= (7a221((2x xF F b E E FV -=-(7b其中m 是体系的约化质量, F i (i =1, 2是透热势能的斜率, F . V x 代表透热势能耦合项, E x 是透热势能. 一般情况下, 电子跃迁是在绝热表象下进行. 基于e 指数模型, 参数a 2和b 2在此表象可以表示为:0222301[((]16(x x a W x W x m x E +−=∂⎡⎤⎢⎥∂Δ⎣⎦==+ (8a 22xE E b E Δ-=(8b其中W +(x 和W ―(x 分别是能量较高和较低的电子态的能量, 此时的(( 2x W x W x E +-+=, 而0E Δ=((2W x W x+--. 其中式(8b中E 为体系能量. 基于此模型, 非绝热跃迁几率可以表示为:0ZN 1exp 4exp ((]x x P ab W x W x π−+−=⎛⎞⎜⎟⎝⎠⎡⎤⎢⎥⎢⎥⎣⎦=-=+(9众所周知, 电子的无辐射跃迁沿着非绝热耦合向量最强的方向进行. 为了计算电子非绝热跃迁几率P ZN 需要首先确定此向量的方向. 对于大分子体系来说, 计算此向量非常耗时, 而实践证明势能面上的接缝线与非绝热耦合向量基本垂直[35], 所以找到此接缝线就意味着确定了电子跃迁的方向. 朱超原等报道称此接缝线可以在运行经典轨迹之前预先确定, 并将体系在此线所处的区域分为三部分, 分别为透热区、绝热区和非绝热区. 划分的标准由参数a 2决定, 当a 2>103时, 体系处于透热区, 此时确定跃迁发生; 当a 2<10-2, 体系处于绝热区, 此时无跃迁发生; 当103≥a 2≥10-2, 体系处于非绝热区, 此时电子跃迁发生与否取决于此时P ZN 是否大于一个0和1之间随机数[35].由式(8a可知, 计算a 2需要势能面的信息. 如图2所示, 我们在SA-CASSCF/6-31G 水平上[16,17]构建了二维势能面, 其中所选活性空间包括2个活性电子及2个活性轨道HOMO 和LUMO, 势能变化沿着二面角DD1和DD2进行. 采用线性最小二乘法[36]拟合得到了此势能面的解析表达式(10.图2 二苯乙烯围绕圆锥相交点OBF-CI 的基态与第一激发态的二维解析势能面,其中变量为组合的二面角DD1和DD2Figure 2 Analytical two-dimensional PESs around OBF-CI for the ground state and the first excited state with respect to the combined inter-nal coordinates DD1 and DD222010101234567891011121314(,exp[(x(]cos(/2cos(/2cos(cos(cos(2cos(2cos(3cos(3sin[(/2]sin[(2/2]sin[(2/2]sin(sin(2sin(2W x y c a x b y y c x c y c x c y c x c y c x c y c x y c x y c x y c x y c x y c x y =----++++++++++++++++++++1516171819202122232425262728sin(22sin(3sin(3sin(32sin(23sin(3 3cos[(/2]cos[(2/2]cos[(2/2]cos(cos(2cos(2cos(22cos(3c x y c x y c x y c x y c x y c x y c x y c x y c x y c x y c x y c x y c x y c x y c+++++++++++++++++++++++++++++29303132cos(3cos(32cos(23cos(33x y c x y c x y c x y +++++++(10其中, x 0=-103.3°和y 0=43.3°为相交点OBF-CI 的DD1和DD2值, 而其他的系数a 1, b 1和c 0~c 32在表1中. 解析势能面与计算势能面的对比表明, 无论S 0还是S 1的平均偏差都小于2.4 kcal •mol -1, 而且最小偏差出现在相交点OBF-CI 附近, 此处平均偏差小于1.0 kcal •mol -1, 即最重要的相交区域的计算结果也最为精确, 这为此后的动力学计算打下良好基础.表1 二苯乙烯围绕圆锥相交点OBF-CI 关于DD1和DD2的基态与第一激发态的二维解析势能面的拟合参数(其中c 0~c 32单位为eVTable 1 The fitted coefficients of two-dimensional S 0 and S 1 PESs around OBF-CI with respect to the combined internal angles DD1 and DD2 (c 0~c 32 in units of eV Index a 1 b 1c 0c 1c 2c 3 c 4c 5c 6S 0 35 3.5 0.495231 364.2436 166.2537 -63.2233-228.305 -12.7773 25.79321 S 1 39 3.9 -0.52219 256.2847 -18.8715-74.255 -85.6398 -4.51131 16.61385 Index c 7 c 8c 9c 10 c 11 c 12 c 13 c 14c 15 S 0 -3.78713 -3.97288 9.467412 106.3829 -36.167 -72.9472 5.205437 -0.08421 -4.58729S 1 -1.65933 -2.44485 -219.158 171.3529 98.32809 -110.7899.156298 -4.96308 -1.1299 Index c 16 c 17 c 18c 19 c 20 c 21 c 22c 23 c 24 S 0 5.134825 3.857498 -6.20916 0.171133 2.090849 -538.156-56.4412 254.7531 157.3086 S 1 0.059523 4.654567 -1.20414 -1.738630.658395 -277.52987.56788 112.7934 47.53832 Index c 25 c 26 c 27 c 28 c 29 c 30 c 31 c 32 S 017.19558 -58.19 -8.161 7.267131 4.132838 -3.08607 1.734321 0.088946 S 1 -7.42468-41.53027.9652671.253993.375719-0.42815-0.71119-0.09718结合解析势能面表达式(10与式(8a, 得到了如图3所示的a 2值. 由此图可知, 沿着DD1约等于-103.35°的直线(即接缝线方向上, a 2都相对较大, 最大值在圆锥相交点OBF-CI 处.当反应轨迹接近此线时, 通过此时的a 2判断体系所处的区域, 可以判断电子是否发生跃迁, 即电子跃迁只可能发生在此接缝线上, 而势能面上的其他区域无需考虑电子是否跃迁. 此方法大大简化了非绝热跃迁几率的计算量, 特别是高维势能面上跃迁几率的计算.图3 关于组合的二面角DD1和DD2的有效耦合参数a 2的三维图 Figure 3 The effective coupling parameter a 2 with respect to the com-bined internal coordinates DD1 and DD23 动力学模拟程序化基于以上所述改进的TSH 方法, 我们实现了半经典动力学模拟的程序化. 此程序适用于任意约束与未约束的分子体系, 特别是那些无法构建全维势能面的大分子体系, 如本文中的二苯乙烯. 因体系不同所需要重新设定的只有动力学过程的初始条件、时间步长、最长模拟时间、模拟完成判据及非绝热跃迁几率等. 这些需要修改的量相对整个模拟程序来说, 工作量很小, 所以相对全量子的动力学程序, 此动力学模拟程序普适性较好. 此程序的流程图如图式1.为了达到可以与全量子动力学模拟相近的计算结果, 半经典动力学模拟过程中需考虑反应的相效应, 即波包演化过程的平均效应. 此效应需要考虑大量的反应轨迹的加权平均. 因此模拟反应动力学过程时, 每一条图式1 新的TSH 程序流程图Scheme 1 Flow chart of new implementation of TSH method反应轨迹的初始坐标q i (0及动量p i (0需要首先在一定范围内随机确定. 初始时间设定为t =0, 体系下一个时刻t +Δt 满足约束条件的坐标q i (t +Δt 及动量p i (t +Δt 可按如下步骤计算:(1计算t 时刻势能所提供的力(/i V q q ∂∂和约束力(/k i g q q ∂∂.(2将上述两种力代入式(5, 计算t +Δt 时刻未满足约束条件的核坐标q i (t +Δt .(3将q i (t +Δt 代入约束方程式(2, 得到非线性方程组式(2, 其中未知量为λk (t , 并计算其所对应的雅克比矩阵J g .(4将g k (q 和J g 作为输入文件, 应用软件MINPACK [31,32]中求解非线性方程组的解λk (t . 此方法中需要不断更新λk (t , 直至约束方程式(2成立.(5将λk (t 代入式(3和(4, 并采用RK4方法求解得到t +Δt 时刻满足约束方程式(2的q i (t +Δt 和p i (t +Δt .(6如果此时反应轨迹满足模拟完成的条件, 或动力学演化时间已经超过设定的模拟时间, 程序终止.(7如果步骤(6的条件不满足时, 基于式(9计算此时体系的非绝热跃迁几率P ZN , 并与一个0到1之间的随机数进行对比. 如果P ZN 大于此随机数时, 电子发生跃迁, 并重新分配体系的动能, 从而调整动量p i (t +Δt .(8将此时的坐标q i (t +Δt 及改变的p i (t +Δt 作为下一个时间步的初始坐标及动量, 重复以上计算, 直至模拟完成.如上所述, 不同的体系需要重新选定体系的初始坐标和动量以及模拟完成的条件. 由图2与其所对应的解析表达式(10可知, 二苯乙烯基态顺式构型的稳定点在DD1和DD2分别为-39.2473º和50.9041°的位置. 本文设定初始的DD1为DD1=-39.2473°±ΔD 之间任意值, 而DD2的取值范围是DD2=50.9041°±ΔD , 其中ΔD =20°.反式构型的稳定点在DD1和DD2分别为-164.3473°和36.7041°的位置. 类似地, 初始设定的DD1的取值范围为DD1=-164.3473°±ΔD, 而DD2为DD2=36.7041°±ΔD 之间的值. 所选坐标基本都在Frank-Condon(FC区域内. 初始动量方面, 设定坐标所选范围内S 1能量的最大值为体系总能量, 即此处体系的总能只有势能的贡献, 而其他初始坐标所对应激发态的势能小于总能, 则其具有初始动能, 并可以按照比例分配到图1所示D1和D2所对应原子C(1, C(2, C(8, C(9, C(10和C(11的动能部分.二苯乙烯从初始的顺式或反式构型激发到第一激发态后, 反应轨迹既可通过电子跃迁回到基态的反应物, 又可生成基态产物. 本文设定模拟完成的条件是: 从顺式的激发态到反式的基态时, 顺式到反式的异构化反应完成; 从反式的激发态到顺式的基态时, 反式到顺式的转变完成; 从顺式的激发态回到顺式的基态或从反式的激发态回到反式基态时, 异构化反应未发生. 模拟完成时, 反应轨迹进入到的顺式或反式构型的收集区域与初始坐标选取范围一致, 也为FC 区域.4 结果与讨论如前所述, 化学反应的量子产率需要从大量反应轨迹的统计平均得到. 所需反应轨迹数目的大小取决于模拟得到的量子产率是否收敛, 即直至增加反应路径不会改变反应的平均量子产率. 如前所述, 我们选定初始的总能为所选初始坐标所对应的最大垂直激发能. 基于此, 表2中提供了100, 500, 1000及2000条反应轨迹模拟的量子产率. 模拟2000条反应轨迹时, 所得量子产率与500条所得结果基本一致, 因此可以确定2000条轨迹足以模拟二苯乙烯的顺反异构化反应. 我们定义反应物(cis-或trans-、未反应轨迹(unreact及产物(trans-或cis-三部分轨迹. 由于此二维势能面关于DD1和DD2坐标的变化满足周期性特点, 未反应轨迹在未能进入反应物或产物收集区域时, 就已经跑出我们所选势能面边界, 因此这部分轨迹与反应物轨迹都归于未生成产物的反应轨迹.表2 二苯乙烯光致顺反异构化统计平均的量子产率Table 2 Cumulative quantum yields with respect to cis- and trans-stilbene photoinduced isomerizationsOBF-CI a cis- to trans- trans- to cis-Trajectories cis-/%Unreact/%trans-/% trans-/% Unreact/%cis-/%100 22.00 18.00 60.00 24.00 10.00 66.00 500 19.40 20.00 60.60 25.80 12.60 61.60 1000 17.40 21.40 61.20 25.20 13.80 61.00 2000 17.25 22.30 60.45(42.3c 25.65 13.90 60.45Exp.b55.0 35.0 45.0 55.0aTotal energy of either cis- or trans- classical trajectory is equal to the maxi-mal vertical excitation energy among all the initial positions. DD1=-39.2473°±ΔD , DD2=50.9041°±ΔD for cis- to trans- isomerization, while DD1=-164.3473°±ΔD , DD2=36.7041°±ΔD for trans- to cis- deforma-tion, where ΔD =20°. b ref. 2~5. c Corrected by taking into account the branch ratio to side reaction DHP [14].由表2可知, 模拟得到反式至顺式的量子产率为60.45%, 与实验值55%基本吻合[2~5]. 另一方面, 顺式至反式的量子产率为60.45%, 明显不同于实验值35%[2]. 以前的报道[14]称, 与反式的二苯乙烯只经过一条反应路径无需修正不同, 当顺式的二苯乙烯从初始稳定点激发到S 1态后, 会经过两条反应路径. 其中一条反应路径经过本文报道的圆锥相交点OBF-CI, 顺式二苯乙烯经过此反应路径的几率为70%. 另一条反应路径对应有30%的几率经过其它圆锥相交点, 其中包括可以生成副产物DHP 的圆锥相交点[2~8]. 因此, 模拟的顺式到反式的量子产率需要经过修正, 即60.45%×0.7=42.3%. 经过修正的结果42.3%与实验值35%基本一致[2~5].为了测试初始条件的敏感性, 我们分别在原有体系总能量的基础上加上0.25 eV 和0.50 eV 的动能, 并在选定的坐标范围内随机选取初始坐标, 模拟2000条反应轨迹. 表3给出了未加初始动能及加入0.25 eV 和0.50 eV 的动能, 三种不同初始条件下顺反异构化反应的量子产率. 对比结果表明, 加入初始动能并没有明显改变所得量子产率, 我们发展的改进的TSH 方法对初始条件的选择并不敏感, 即此模拟方法可靠性较高, 可以很化学学报好地应用于如二苯乙烯这样的中等大小分子体系的动力学模拟. 表3 二苯乙烯光致顺反异构化 2000 经典轨迹模拟的统计平均量子产率 Table 3 Cumulative quantum yields with respect to cis- and trans-stilbene photoinduced isomerizations from the simulations of 2000 classical trajectories OBF-CIa Eplus/eV 0.00 0.25 0.50 Exp.b a 研究论文 cis- to transtrans- to ciscis-/% Unreact/% trans-/% trans-/% Unreact/% 17.25 22.30 60.45(42.3c 25.65 13.90 17.35 23.55 59.10(41.4c 25.65 16.25 16.70 24.35 58.95(41.3c 25.70 16.95 55.0 35.0 45.0 cis-/% 60.45 58.10 57.35 55.0 Total energy of either cis- or trans- classical trajectory is equal to the sum of Eplus and the maximal vertical excitation energy among all the initial positions. DD1=-39.2473°±ΔD, DD2=50.9041°±ΔD for cis- to trans- isomerization, while DD1=-164.3473°±ΔD, DD2=36.7041°±ΔD for t rans- to cisdeformation, where ΔD=20°. b ref. 2~5. c Corrected by taking into account the branch ratio to side reaction DHP[14]. 为了研究反应的机理, 我们选取 100 条典型经典轨迹考察反应过程中二苯乙烯的动力学信息. 图 4 给出了顺反异构化过程中二面角 DD1 随时间的变化. 由图 4a 可知, 顺式二苯乙烯的电子受激激发后, 大多数反应轨迹的 DD1 都逐渐振荡接近最小值-180°, 此时的 DD1 已经满足反应完成的条件, 生成反式二苯乙烯. 另一方面 , 此异构化过程中也存在少量轨迹逐渐振荡增大到-40°左右. 此时的 DD1 在反应初始坐标设定的范围, 生成基态的顺式二苯乙烯, 对应未发生顺式到反式的异构化反应. 反式到顺式的转化过程中, DD1 的变化基本与顺式到反式反应时的变化相反 . 可以在图4b 看出 , DD1 的主要变化是振荡增大 , 而其它少数反应轨迹振荡减小到接近-150°. 类似地, 反式二苯乙烯激发后既可以生成产物顺式构型也可以转变到基态反式构型. 反式激发态到基态对应未发生反式到顺式的异构化反应. 本文也研究了二面角 DD2 随时间的变化. 由图 5 可以看出 , 无论顺式还是反式 , 大多数的反应轨迹中 DD2 的变化呈现近似周期性振荡. 其中顺式反应平衡位置约为 40°, 反式异构化过程中 DD2 的平均值约为 45°. 相比 DD1 的变化, DD2 的变化相对较小, 因此对于反应坐标贡献也较小. 另一方面, 有少量的反应轨迹中顺式的 DD2 振荡平衡位置上移到 60°左右, 而部分反式到顺式的异构化过程中, DD2 的平均值则既有增大又有减小. 相对 DD1 的变化, 此部分反应轨迹中 DD2 的变化也相对较小, 同样说明 DD2 对反应路径的贡献较小. 图 4 100 条二苯乙烯异构化的典型轨迹中组合二面角 DD1 随时间的变化。
ICH指导原则
Q8 Pharmaceutical Development 药物开发
Q8(R2) Pharmaceutical Development 药物开发
Q8/9/10 Q&AsR4Q8/Q9/Q10 Implementation
Q9 Quality Risk Management 质量风险管理
Q9 Quality Risk Management Q8/9/10 Q&AsR4Q8/Q9/Q10 Implementation
Changes in their Manufacturing Process 基于不同生产工艺的生物技术产品/生物产品的可比较性
Q6A- Q6B Specifications规格
Q6A Specifications : Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances质量规格:新原料 药和新制剂的检验程序和可接收标准:化学物质( 包括决定过程)
Q1C Stability Testing for New Dosage Forms新剂型的稳定性试验 Q1D Bracketing and Matrixing Designs for Stability Testing of New
Drug Substances and Products 原料药和制剂稳定性试验的交叉和矩阵设计
Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients活性药 物成份的GMP指南
Q7 Q&As Questions and Answers: Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
教育部人文社科项目英文
教育部人文社科项目英文IntroductionThe Ministry of Education in China has initiated various projects to promote research and development in the field of humanities and social sciences. These projects aim to enhance academic excellence, advance knowledge, and contribute to the intellectual and cultural development of the nation. In this article, we will delve into the significance of the Ministry of Education’s humanities and social science projects, their objectives, and the impact they have on education and research in China.Objectives of the Humanities and Social Science ProjectsThe Ministry of Education’s humanities and social science projects encompass a wide range of disciplines, including but not limited to history, philosophy, sociology, psychology, and education. The main objectives of these projects are as follows:1.Encouraging research and academic innovation: The projectsprovide researchers and scholars with financial support to pursue innovative and groundbreaking research in their respective fields.This promotes academic excellence and contributes to theadvancement of knowledge in humanities and social sciences.2.Promoting interdisciplinary collaboration: The projects encouragecollaboration among scholars from different disciplines, fosteringa multidisciplinary approach to research. This collaboration leadsto a better understanding and integration of diverse perspectives in addressing complex societal issues.3.Supporting the development of young researchers: The projectsallocate special funds to support early-career researchers inhumanities and social sciences. This investment in young talenthelps cultivate the next generation of scholars and promotesacademic success.Implementation and EvaluationThe implementation of the Ministry of Education’s humanities and social science projects involves a rigorous process. The following stepsoutline the typical implementation and evaluation procedure:1.Project Proposal Submission: Researchers submit project proposals,outlining the objective, methodology, and expected outcomes oftheir research. These proposals undergo a peer-review process,where experts in the respective fields evaluate the feasibilityand significance of the proposed projects.2.Funding Allocation: Based on the review outcomes, funding isallocated to the selected proposals. The Ministry of Educationensures that the funds are distributed fairly and in accordancewith the project’s requirements.3.Project Execution: Researchers commence their research projects,adhering to the proposed methodology and timeline. Regularprogress reports are submitted to the Ministry of Education,ensuring transparency and accountability.4.Final Evaluation: Upon completion of the projects, researcherspresent their findings and submit a final report for evaluation.The evaluation committee assesses the quality of research,contribution to knowledge, and overall impact of the projects.Impact on Education and ResearchThe Ministry of Education’s humanities and social science projects have a profound impact on both education and research in China. Some notable impacts include:1.Advancement of knowledge: The projects have significantlycontributed to the advancement of knowledge in various fields ofhumanities and social sciences. The research outputs are published in top-tier academic journals, helping to shape scholarlydiscourse and contribute to the global body of knowledge.2.Promotion of critical thinking: The projects promote criticalthinking and analytical skills among researchers and students.Through rigorous research and analysis, scholars are able todevelop a deeper understanding of complex societal issues andpropose innovative solutions.3.Enhancement of teaching quality: The research outcomes informteaching practices and curriculum development in universities and colleges. The projects provide valuable insights and findings that can be incorporated into the classroom, enriching the learningexperience for students.4.Cultural and intellectual enrichment: The projects contribute tothe cultural and intellectual development of society. They explore the rich history, philosophical traditions, and social dynamics of China, facilitating a better understanding and appreciation of the nation’s heritage.ConclusionThe Ministry of Education’s humanities and social science projects play a vital role in promoting research and development in China. Through funding and support, these projects enable researchers to push the boundaries of knowledge, foster collaboration across disciplines, and contribute to the intellectual and cultural enrichment of the nation. The impact of these projects on education, research, and society as a whole is significant and far-reaching. It is essential to continue supporting and nurturing the humanities and social sciences for the betterment of China’s academic landscape.。
工程解决方案英文
工程解决方案英文IntroductionEngineering problem solving is an essential aspect of the engineering process, and it requires a systematic approach to ensure that the solutions are effective and efficient. Engineers are faced with a wide range of problems, from simple technical issues to complex and multifaceted challenges. In this paper, we will discuss the various steps in the engineering problem-solving process and present a comprehensive approach to solving engineering problems.Identify the ProblemThe first step in the engineering problem-solving process is to identify the problem. This may seem obvious, but it is essential to clearly define the problem and understand its scope and complexities. It is important to ask the right questions and collect relevant data to gain a thorough understanding of the problem. In many cases, the problem may not be well defined, and it is crucial to work with stakeholders to identify the problem accurately. Once the problem is clearly articulated, the next step is to analyze it, gather data, and define the criteria for a good solution.Analyze the ProblemAfter the problem has been clearly identified, the next step is to analyze it. This involves understanding the underlying causes of the problem, identifying the constraints, and evaluating the possible solutions. Engineers need to use various analytical tools and techniques to break down the problem into its component parts and understand the interrelationships between them. This may involve using mathematical models, simulations, and other analytical methods to gain insights into the problem. It is also important to consider the potential impacts of the problem on various stakeholders and assess the risks associated with different solutions.Generate Possible SolutionsOnce the problem has been thoroughly analyzed, the next step is to generate possible solutions. This stage involves brainstorming and coming up with creative and innovative ideas to address the problem. Engineers should be open to new ideas and think outside the box to explore all potential solutions. It is important to involve a diverse group of stakeholders in this process to ensure that a wide range of perspectives are considered. Engineers should also consider the ethical and sustainability implications of the solutions to ensure that they align with the organization's values and long-term goals.Evaluate and Select the Best SolutionAfter generating a range of possible solutions, the next step is to evaluate and select the best solution. This involves comparing the solutions against the criteria defined earlier andassessing their feasibility, cost-effectiveness, and impact. Engineers should also consider the potential risks and trade-offs associated with each solution and conduct a thorough analysis to determine the best course of action. It may be necessary to use decision-making tools, such as decision matrices or cost-benefit analysis, to assess the solutions objectively and make an informed decision.Implement the SolutionOnce the best solution has been selected, the next step is to implement it. This may involve developing a detailed plan, allocating resources, and coordinating with various stakeholders to ensure that the solution is implemented effectively. Engineers need to consider the potential barriers to implementation and develop strategies to overcome them. It is important to communicate the plan to all relevant stakeholders and ensure that everyone is aligned and committed to the solution. Engineers should also monitor and evaluate the implementation process to identify any issues and make adjustments as necessary.Review and Learn from the ExperienceThe final step in the engineering problem-solving process is to review and learn from the experience. This involves assessing the outcomes of the solution and identifying lessons learned. Engineers should evaluate the effectiveness of the solution and identify any areas for improvement. It is important to document the entire problem-solving process and share the findings with the broader engineering community to contribute to the collective knowledge base. By reflecting on the experience, engineers can improve their problem-solving skills and enhance their ability to tackle future challenges.Case Study: A Comprehensive Approach to Solving an Engineering ProblemTo illustrate the comprehensive approach to solving engineering problems, let us consider a case study involving the design and implementation of a sustainable energy solution for a manufacturing facility. The facility is currently reliant on non-renewable energy sources and is facing increasing pressure to reduce its carbon footprint and operating costs. The management has tasked a team of engineers to develop a sustainable energy solution that meets the facility's energy needs while minimizing its environmental impact.Step 1: Identify the ProblemThe first step is to clearly identify the problem. The team works with key stakeholders to understand the facility's energy needs, current energy consumption, and environmental impact. They also consult with energy experts to gain a thorough understanding of sustainable energy options and regulatory requirements. Through this process, the team defines the problem as the need to develop a sustainable energy solution that reduces the facility's dependence on non-renewable energy sources and lowers its carbon emissions. Step 2: Analyze the ProblemOnce the problem has been defined, the team conducts a comprehensive analysis to understand the underlying causes and constraints. They evaluate the facility's energy consumption patterns, identify the potential sustainable energy sources, and assess the technical and economic feasibility of different solutions. The team uses mathematical models and simulations to analyze the energy requirements and the potential impact of different energy sources on the facility's operations.Step 3: Generate Possible SolutionsThe team then engages in a brainstorming process to generate possible solutions. They consider a wide range of sustainable energy options, including solar, wind, and biomass energy, and explore innovative technologies, such as energy storage and energy efficiency measures. The team also considers the potential partnerships with external energy providers and government incentives to support the adoption of sustainable energy solutions.Step 4: Evaluate and Select the Best SolutionAfter generating a range of possible solutions, the team evaluates and selects the best solution. They assess the feasibility, cost-effectiveness, and environmental impact of each solution and consider the potential risks and trade-offs. The team uses a decision matrix to compare the solutions and ultimately selects a combination of solar and wind energy, supported by energy storage and energy efficiency measures, as the best solution.Step 5: Implement the SolutionWith the solution selected, the team develops a detailed implementation plan and allocates the necessary resources. They collaborate with external energy providers and government agencies to secure the required permits and funding. The team also coordinates with the facility's management and staff to ensure a smooth transition to the new sustainable energy solution. Throughout the implementation process, the team monitors the progress and addresses any issues that may arise.Step 6: Review and Learn from the ExperienceFinally, the team reviews the outcomes of the solution and identifies lessons learned. They evaluate the performance of the sustainable energy solution and its impact on the facility's operations, costs, and environmental footprint. The team documents the entire problem-solving process and shares the findings with the broader engineering community to contribute to the collective knowledge base. They also identify opportunities for continuous improvement and explore ways to further enhance the facility's sustainability efforts.ConclusionThe comprehensive approach to solving engineering problems involves a systematic and collaborative process that encompasses identifying, analyzing, generating, evaluating, and implementing solutions. By following this approach, engineers can effectively tacklecomplex challenges and develop innovative solutions that meet the needs of various stakeholders. Case studies, such as the one presented above, illustrate how this approach can be applied in real-world engineering scenarios to deliver practical and sustainable solutions. As engineers continue to face evolving challenges, the comprehensive approach to problem-solving will remain a critical skill for driving innovation and advancing the field of engineering.。
Revit软件与Robot结构分析软件的链接 使用Dynamo自动创建智能模型说明书
CES500699Boosting project performance. Engineering Automation Workflow usind Dynamo.Wojciech Mleczko JacobsGary Furphy JacobsEmmanuel Lagardette AutodeskDescriptionRevit software is a powerful tool in the building information modeling (BIM) world that can be linked to Robot Structural Analysis software. Structural analysis requirements and constraints make this link difficult to manage and often result in time-consuming manual adjustments in models. This class will explain how you can use Dynamo for automated creation of intelligent models (including MEP design) and structural analysis models with one engineering data set input based on shaft structure and pumping stationproject example. The intelligent model output includes all necessary information, schedules with concrete, and mapped required reinforced steel quantities. The second model output uses the same unique geometry while considering all structural load cases and combinations required for detailed design. We'll show you how this engineering workflow allows users-with a previously impossible agility- to react quickly to change, leaving more time to on focus on core engineering rather than model and deliverable generation.SpeakersWojciech MleczkoCivil engineer interested in bridge and tunnel structures, developingin BIM modeling and structural analysis.Follow Wojciech on LinkedIn:https:///in/mleczkowojciech/Gary FurphyGary is the Digital Engineering & Delivery Solutions for Jacobs inthe Middle East. He would classify himself as a Technologist, with20+ years of experience across the world and cross-sectorknowledge in Digital Delivery for Design, Construction andOperations, managing information delivery for assets. Leadingteams and transforming the way with work in BIM / VDC delivery.Follow Gary on LinkedIn:https:///in/garyfurphy/Emmanuel LagardetteEmmanuel is an expert in structural analysis with more than 28years' experience in design technology and the AEC industries. Inhis current role, he leads a team of technical consultants solvingcomplex problems to customers' advanced requirements.Follow Emmanuel on LinkedIn:https:///in/emmanuel-lagardette/IntroductionManaging and implementing changes is a common challenge for any large-scale project. Designers and engineers must make decisions based on data from all the disciplines involved, which constrained by ever tighter schedules develop their design in parallel. The change management strategy strongly influences budget evaluation and timeliness.In most cases, the design of stormwater collection wells is standardized to homogenize maintenance operations during the operation phase. This allows the automation of the various tasks necessary for their design.This article describes the detailed and optimized design process of these wells, using digital twins. This process leverages the use of Revit, Robot Structural Analysis, Dynamo and the APIs (Application Programming Interface) of these tools via the Python programming language.This process allows the creation of:• a physical model in Revit that includes, in addition to geometry, metadata and reinforcement quantities,• a calculation model in Robot Structural Analysis including support conditions, load cases, or combinations.From these 2 models the set plans (plan view, sections, and 3D view) and the calculation note are generated automatically.In addition, it is easy to carry out, easily and quickly, once again all these tasks with different input data depending on the changes to be taken into account.The risk of error or inconsistencies that can occur when these tasks are performed manually are then drastically reduced.ChallengeDuring each major project, we face serious challenges in the design process involving the management and implementation of significant changes. The mentioned changes may be dictated by many factors, not only structural ones, leading to the requirement to consider many issues in parallel (Table 1). The change management approach influences how you price, design, and manage project delivery within budget. In most cases, shaft configurations are standardized to ensure consistent operation and maintenance procedures, allowing for the development of task sequences that minimize the level of effort required for each modification.Table 1. Change factors faced during the projectSubject Change factorsClient Influence on general arrangement, alignment, shaft location and incoming connectionsLand Development Planning Influence on the location of the structure, alignment and incoming connectionsEnvironmental Influence on the location of the structure, alignment and incoming connectionsHydraulics Influence on the flow requirements (sizing), tunnel sizing, number of incoming connection connections and drop structuresCFD Modeling Analysis Influence on the flow requirements (sizing) and general arrangement of drop structuresGeotechnics Influence on restraints, loading and structural design Construction Influence on general arrangementUtilities Influence on the location of the structure, alignment and incoming connectionsOperation and Maintenance Influence on the general arrangement, access and safety requirements and methods of maintenanceThis involves solving multidisciplinary problems in parallel. The change management strategy strongly influences the budget, the design process, and the timely management of deliverables.Figure 2. Simplified Design WorkflowThe sequence automation required to design stormwater collection wells minimizes the effort required to account for changes during the project.Implemented Solution WorkflowThe solution implemented to minimize the level of effort is mainly based on the automatization of the main tasks conducted to develop project deliverables such as drawings, schedules and quantities, and structural analysis report.The following main tasks has been automated in separate custom tools all connected to the engineers input data Excel file when relevant:A1. Creation of the BIM modelA2. Creation of the structural analysis model from the BIM modelA3. Creation of the structural analysis reportA4. Rebar quantityA5. Creation of the drawings and schedulesThey are controlled by an Excel file including all input data needed to manage both the BIM and structural analysis model of all shafts of the project. This allows to manage one single source of truth for input data easily modifiable depending on required changes all along the project lifecycle. Each task can be performed independently but need to remain in sequence. The engineer retains full control through the management of the excel file and can carry out parametric studies and modification on request with a reduced level of effort. Creating the digital twin from a single source also avoids issues with version control and discrepancies between outputs that are often an issuewith transferring data sets between software.Figure 3. Solution workflowThe workflow is supported by a cloud-based Common Data Environment (CDE) in which input data, models and deliverables are stored. This CDE allows to give access to project materials to any relevant stakeholders for modification or review purpose and contributes to make the workflow even more seamless.To develop this workflow the following software packages have been used:Table 2. SoftwareWorkflow Component SoftwareInput data Microsoft ExcelBIM model, drawings and schedules Autodesk RevitStructural Analysis Model Autodesk Robot Structural AnalysisAutomation Dynamo for Revit and Microsoft ExcelCommon Data Environment BIM 360As shown in the table above the automated tasks are programmed with Dynamo for Revit, Python scripts and Excel macros developed in Visual Basic for Application. Automating the task using a Dynamo Graph offers the flexibility to quickly adapt the script in case of design changes affecting the general arrangement of the shaft and is the primary tool to automate the creation of the BIM model in Revit but also of the structure analysis in Robot Structural Analysis.Workflow ExecutionMain input dataThe input data is grouped within the Excel workbook in which the parameters of all project shafts is stored. It includes several worksheets, arranged contextually for each different types of input data such as the description of the overall geometry, the coordinates of the shaft, material properties, loads and load cases, load combinations and most structural design Input parameters for the Robot model executing the concrete design.Figure 4. Structure geometry and coordinates in Microsoft ExcelFigure 5. Structure material properties in Microsoft ExcelThe structure of the data in the workbook has been defined to simplify the data gathering and checking for the project engineer and includes formulas converting those data to make it readable by the Dynamo graph.Figure 6. Structure material properties in RevitCreation of the BIM modelFrom the input data structured in the Excel file the BIM model is generated automatically in Revit.Figure 7. BIM model in RevitEach component of the shaft is named and identified with a unique marker. In addition, to the geometry and properties of the shaft components, the custom graph (ie. Script in Dynamo) a utomatically defines the analytical model of the shaft supporting the creation of the structural analysis model in the next step of the workflow.Even if the analytical model is managed by default in Revit the graph allows to adjust it as required by the structural analysis principles and define exactly the elevations, location, slabsor walls, and the exact dimension of the opening. The graph also defines the boundary conditions of the shaft considering different ground layers and their respective stiffness.Figure 8. Analytical model in RevitCFD ModelingA further advantage of the BIM model is the possibility of easy and quick export to *.sat format. The file is saved in this way on the CDE platform that simplifies the build of the computational fluid dynamics (CFD) analysis ensuring data consistency and reduced level of effort. Based on the specified flows, the CFD model establishes the hydraulic boundaries, verifies the overall dimensions and provides feedback for adjustment based on hydraulics of the shaft configuration. The implementation of these CFD outputs back I nto the source data is simplified through adjustments of the inputs parameters and reruns of the script.The hydraulic engineer can simply communicate any comments for change on the same platform through comments directly in the BIM model that gets assigned directly as a task to the civil engineer in charge. The use of these commenting functions ensure clear assignments of tasks, real time availability of comments, visual context for ease of understanding and a close out register that can be used to track status of change management.Creation of the structural analysis modelThe second step of the workflow aims to create the structural analysis model of the shaft leveraging the main input data and the BIM model created as part of the previous steps.Figure 9. Structural model in Robot StructuralAnalysisFigure 10. Structural model in Robot StructuralAnalysisThe main part of the structural analysis model is created from the BIM model, this guarantees data consistency between the two models, creating a digital twin between the geometric and structural model. But even if the analytical model created during the previous steps has been adjusted it is neither perfect nor complete. During the transition of the model between Revit and Robot Structural Analysis the Revit analytical model is adjusted as needed and structural properties are added based on the main input data from the Excel workbook such as linear releases between floors and walls, loads, load cases, combinations, meshing parameters and reinforced concrete parameters.Figure 11. Ground pressure load in Robot Structural AnalysisFigure 12. Load cases defined in ExcelAt the end of this step a full structural analysis model is available in Robot Structural Analysis. The analysis can be performed as well as the reinforced concrete design to determine the required rebar.Seismic load applicationConsideration of seismic loads in underground structures is one of the more complex issues, there are several structural design approaches. Not all are supported by all structural softwares. Due to the type and dimensions of structure, it was decided to apply the approach developed by Y. Hashash, consisting in estimating the displacement of the soil onto the structure on the basis of:•ratio of peak ground velocity to peak ground acceleration,•distance from source to site,•ratio of ground motion at structure depth to motion at ground surface,•shear wave velocity, the influence of groundwater on the structure and•the acceleration of the structure are also taken into account.This structural design approach is not an available function in Robot for structural analysis. The structure of the workflow allowed us to develop an automated inputfunction into Robot, that enabled the execution with these theoretical considerations.This was achieved via conversion of the ground displacement calculated in Excel to an equivalent load. The entire process of the application of the seismic load has been automated, the soil displacement calculated using the formulas in Excel, converted to the equivalent load using a prepared script, and then applied to the finite element nodes as a nodal force - assigned to the appropriate load case.Figure 13. Seismic nodal forces in Robot Structural AnalysisThe applied script introduces the flexibility to changes and improves the speed of re-applying the load that disappears after manual editing the dimensions of the finite element mesh if needed.CalculationThe next workflow step is to obtain the structural analysis results by manually running the analytical calculations.The calculation of the required reinforcement is carried out via the use of the proposed reinforcement in the excel input sheet and use within Robot to a predefined standard such as Eurocode.All parameters and data necessary for the calculation are pre-defined in Excel, such as: cement class, structure class, creep coefficient, environmental classification, allowed crack limits, allowed deflection, concrete cover and rebar diameters.Figure 14. Reinforcement parameters defined inExcelFigure 15. Reinforcement parameters defined inExcelFigure 16. Reinforcement parameters defined in ExcelThis approach provides an easy, fast, and transparent way to define data, which saves time and reduces the risk of errors that can occur when defining this data in a structural analysis program. Quality Control on the structural analysis is further improved through the structured way input data is presented. The use of the digital twin also ensures that Model geometries can be checked via a check of the project drawings as the deliverables are all dynamically linked.Post processingThe essential part of the design process is the final deliverables in the form of Models, Drawings, Schedules, and Structural analysis reports. Unfortunately, the level of effort required to produce structured and concise deliverables is often underestimated. Hence a particular focus was given to develop automation scripts for these final reports and drawings.Rebar quantityAfter calculating the required amount of reinforcement, the data with these results for individual structural elements are automatically exported to the BIM model, which is the core with all information about the designed structure. Based on this model, drawings and schedules are generated, defining elements such as volume of concrete, the average amount of required reinforcement (top and bottom in each direction) and the mass of requiredreinforcement. An important item is the ratio of reinforcement to concrete, which allows the designer to easily and quickly assess the structure and decide on its possible optimization or adjustments to improve capacities. The data in the BIM model can be used to produce Bill of Quantities and other BIM workflows such as scheduling, sequencing etc.Creation of the drawings and schedulePlans, Elevations, Sections, 3D Views and Schedules are automatically placed in the appropriate position and scale on the drawings. The outstanding element is the annotation of the drawings. Dates, revisions, and data of persons responsible for the project, such as: designer, reviewer, are controlled by data defined in the Excel. This solution allows us to easily edit these issues, avoiding mistakes in case of many changes.Figure 17. Revit Sheet with Plan View at different levelsFigure 18. Revit Sheet with SectionsCreation of the structural analysis reportRequired components of the structural analysis report are grouped using a Dynamo graph including the list of load cases, views of the different structural components with meshing, internal force colour map or required reinforcement heat maps.Figure 19. Mxx [kNm] results in Robot Structural AnalysisFigure 20. Myy [kNm] results in Robot Structural AnalysisFigure 21. Forces envelope table in Robot Structural AnalysisCommon Data EnvironmentAs already mentioned, all input data, models, Dynamo graph, and outputs are stored in acloud-based Common Data Environment, in this case, Autodesk BIM 360, set up for the project helping to provide the same and latest up to date project data to all stakeholders, managing version control and change. This is considered essential when a significant amount of changes happen during the project as it can be used as a single source of truth for everyone reducing the risk of errors. Furthermore, the development of a focused workflow ensures full control at any stage of the project.Figure 22. Project management on BIM360 Figure 23. Project files on BIM360BenefitsAutomation of the design process in the presented workflow ensures that engineers can focus on the optimization of structure through the ease of editing and rerunning of scripts. As a result, the engineer is released from carrying out mundane tasks to track changes, edit base information, reproduce existing deliverables with minor changes and edits, and focus his attention on details and improvements.Although the development of such workflows requires considerable time, focus and effort, the resulting the use of the workflows still reduces the overall level of effort required for project execution. The benefits are significant for major projects with many similar structures and less so if only a small number of structures are analysed.Another important advantage is the higher quality of the engineering output and deliverables, the ability to eliminate errors, discrepancies and inaccuracies that may occur during manual modelling, leading to improved quality . The information is created in a format that allows for conversions for other deliverables that are not addressed in this workflow. Industry focus such as the IFC initiative from buildingSmart ensures that further potential can be unleashed via format compatibility in the future.ConclusionAs mentioned above, the proposed solution has many advantages, but it should be assessed when its use is profitable. Based on the collected data on the valuation of the time of manual execution of complete construction models and the estimated time devoted to automatic modeling, taking into account the time for development or adaptation of the script for the current project, we achieve total tool efficiency with at least 4 structures (as shown in the figure below). However, the determining factor remains the number of changes made during the design process.Furthermore, the workflow and programming development has allowed the engineers to understand efficient working methods application in even a manual approach. It highlighted that tools available on the market allow for efficiencies, notwithstanding whether they are used in a manual or automated approach, but that there is work to be done from the Engineer perspective to achieve complete Design, Engineering and Analysis as an Integrated solution.。
计算机科学与技术毕业论文参考文献示例
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Analytical_Methods
6
ICH Q8(R2) and Analytical Methods
• ICHQ8(R2) doesn’t explicitly discuss analytical method development. • However, concepts apply:
12
Analytical Method “Design Space”/ “MODR”
• A science and risk based and multivariate approach to evaluate effects of various method input variables on method performance • Typically DoE (Design of Experiment) is used to find ranges for instrument operating parameters, to understand sample preparation variations and variations of method precision. • Method performance criteria are response factors • Can be conducted together with method validation
2
Analytical Methods – A Key Part of Control Strategy
• Control Strategy (ICH Q10)
– assures process performance and product quality – includes parameters and attributes related to drug substance and drug product materials – includes components, facility and equipment operating conditions – includes in-process controls, finished product specification, and the associated methods and frequency of monitoring and control Right Analytics at the Right Time
能够很好地解决问题英文作文
能够很好地解决问题英文作文英文回答:As a highly proficient problem-solver, I possess a multifaceted arsenal of cognitive and analytical skills that enable me to effectively navigate complex challenges and derive optimal solutions. My approach to problem-solving is characterized by a systematic and logical methodology that incorporates various techniques and strategies.Foremost, I commence by defining the problem comprehensively, ensuring a clear understanding of its nature, scope, and potential consequences. This initial step lays the foundation for a targeted and efficient approach. Next, I engage in thorough research and information gathering to acquire a comprehensive understanding of the relevant context and factors.Subsequently, I analyze the gathered data critically,employing a combination of analytical tools and frameworks to identify patterns, interrelationships, and potential root causes. This meticulous analysis provides insightsthat illuminate the problem's underlying complexities and inform the development of potential solutions.With a sound foundation of knowledge and analysis, I generate a comprehensive set of potential solutions, meticulously evaluating each option's viability, feasibility, and potential impact. I utilize a combination of creative thinking and logical reasoning to explore both conventional and unconventional approaches.Once a suitable solution has been identified, I develop a detailed implementation plan that outlines the necessary steps, resources, and timelines. This plan ensures a structured and systematic approach to executing thesolution and achieving the desired outcomes.Throughout the problem-solving process, I maintain a high level of flexibility and adaptability, recognizingthat unexpected challenges may arise. I engage in ongoingmonitoring and evaluation to assess progress, identify potential roadblocks, and make necessary adjustments to the implementation plan.Furthermore, I am skilled in communicating complex technical concepts and solutions clearly and effectively to diverse audiences. My ability to convey my ideas persuasively and inspire confidence in my recommendations enhances the likelihood of successful implementation and adoption.In summary, my exceptional problem-solving abilities empower me to effectively tackle complex challenges, generate innovative solutions, and execute them with precision. My systematic approach, analytical rigor, and unwavering determination enable me to consistently deliver optimal outcomes in a wide range of professional and academic settings.中文回答:作为一名优秀的问题解决者,我拥有多方面的认知和分析技能,使我能够有效地驾驭复杂的挑战并得出最佳解决方案。
农林经济管理 英语
农林经济管理英语Agricultural and Forestry Economic ManagementThe field of agricultural and forestry economic management is a crucial and multifaceted discipline that encompasses the efficient and sustainable use of natural resources, the optimization of production systems, and the strategic management of agribusiness and forestry enterprises. This field plays a vital role in ensuring food security, environmental conservation, and the economic prosperity of rural communities worldwide.At its core, agricultural and forestry economic management is concerned with the complex interplay between natural, human, and financial resources in the context of agricultural and forestry production. It involves the application of economic principles and analytical tools to the planning, organization, and control of various agricultural and forestry activities, ranging from crop cultivation and livestock farming to timber harvesting and forest management.One of the primary responsibilities of agricultural and forestry economic managers is to analyze market trends, consumer preferences, and global trade dynamics. By understanding thesefactors, they can develop strategies to maximize the profitability of agricultural and forestry enterprises while ensuring the long-term viability of the industry. This includes the identification of new market opportunities, the implementation of effective marketing and distribution channels, and the optimization of supply chain management.Another crucial aspect of this field is the management of natural resources. Agricultural and forestry economic managers must balance the need for productive and efficient use of land, water, and forest resources with the imperative of environmental sustainability. This involves the implementation of sustainable agricultural and forestry practices, the development of innovative technologies and techniques, and the integration of environmental considerations into decision-making processes.In addition to managing natural resources, agricultural and forestry economic managers must also oversee the financial and operational aspects of their respective enterprises. This includes the development of budgets, the allocation of resources, the implementation of cost-effective production methods, and the management of human resources. By optimizing these elements, they can ensure the long-term financial viability and competitiveness of their organizations.Furthermore, agricultural and forestry economic managers play a crucial role in the formulation and implementation of public policies and regulations. They work closely with government agencies, policymakers, and other stakeholders to develop and advocate for policies that support the growth and sustainability of the agricultural and forestry sectors. This includes the design of incentive programs, the establishment of environmental regulations, and the facilitation of access to financing and other resources.The field of agricultural and forestry economic management is constantly evolving, with new challenges and opportunities emerging in response to changing global trends, technological advancements, and societal demands. Professionals in this field must be adept at adapting to these changes, continuously updating their knowledge and skills, and adopting innovative approaches to problem-solving.In conclusion, agricultural and forestry economic management is a multifaceted and critical discipline that plays a vital role in ensuring the long-term sustainability and prosperity of the agricultural and forestry sectors. By leveraging their expertise in economic analysis, natural resource management, and strategic planning, agricultural and forestry economic managers contribute to the development of resilient and thriving rural communities, the preservation of the environment, and the enhancement of global food security.。
英语阅读教学方法
英语阅读教学方法Teaching English reading involves a variety of methods and strategies to help students comprehend, analyze, and interpret texts. One effective approach is the use of authentic materials such as newspapers, magazines, and literature to expose students to real-life language use. By engaging with authentic texts, students can improve their reading skills while also gaining a deeper understanding of the cultural context in which the language is used. Authentic materials provide students with opportunities to encounter language in a natural and meaningful way, which can enhance their overall language proficiency.教授英语阅读涉及各种方法和策略,旨在帮助学生理解、分析和解释文本。
其中一种有效途径是利用真实材料,如报纸、杂志和文学作品,使学生接触真实生活中的语言使用。
通过接触真实文本,学生可以提高阅读能力,同时深入了解语言使用的文化背景。
真实材料为学生提供了在自然而有意义的环境中遇到语言的机会,这可以增强他们的整体语言水平。
Another important aspect of teaching English reading is the use of pre-reading strategies to help students activate their priorknowledge and set a purpose for reading. Pre-reading activities such as brainstorming, predicting, and generating questions can help students make connections between their own experiences and the text, which can enhance their comprehension and engagement with the material. By guiding students through pre-reading activities, teachers can help them build a foundation for understanding and interpreting the text, making the reading process more meaningful and effective.教授英语阅读的另一个重要方面是利用先导读策略,帮助学生激活他们的先前知识,并为阅读设定一个目的。
高中英语新课标全称
高中英语新课标全称The New Curriculum Standard for High School EnglishThe high school English curriculum has always been a crucial component of the education system, providing students with the necessary skills and knowledge to effectively communicate, analyze, and engage with the world around them. In recent years, educational authorities have recognized the need to update and refine these standards to better align with the evolving demands of the 21st century. The introduction of the New Curriculum Standard for High School English marks a significant step forward in this process, aiming to equip students with a more comprehensive and adaptable set of linguistic and critical thinking abilities.At the core of this new standard is a heightened emphasis on the development of well-rounded communication skills. The curriculum places a greater emphasis on not only the mechanics of the English language, such as grammar and vocabulary, but also on the practical application of these skills in various contexts. Students will be expected to demonstrate proficiency in both oral and writtenexpression, with a particular focus on the ability to articulate complex ideas, engage in persuasive argumentation, and effectively convey information to diverse audiences.One of the key innovations of the New Curriculum Standard is its integration of digital literacy. In an increasingly technological world, the ability to navigate and utilize digital platforms has become essential for academic and professional success. The new standard acknowledges this reality by incorporating the study of digital media, including the evaluation of online sources, the creation of multimedia presentations, and the effective use of digital communication tools. By equipping students with these skills, the curriculum aims to prepare them for the demands of the modern workforce and the ever-evolving landscape of information dissemination.Another crucial aspect of the New Curriculum Standard is its emphasis on critical thinking and analytical skills. Rather than relying solely on the memorization of facts and literary concepts, the new standard encourages students to engage in deep, reflective analysis of texts, ideas, and societal issues. This approach fosters the development of critical reasoning abilities, enabling students to effectively evaluate arguments, identify biases, and formulate well-supported conclusions. The curriculum also places a greater emphasis on the study of diverse literary and cultural perspectives,promoting a more nuanced understanding of the world and the human experience.The implementation of the New Curriculum Standard also reflects a shift in the way English language instruction is delivered. The new standard places a greater emphasis on collaborative learning, with students encouraged to engage in group discussions, peer-to-peer feedback, and project-based learning. This approach not only enhances students' communication skills but also fosters the development of essential teamwork and problem-solving abilities. Additionally, the curriculum incorporates a more personalized and adaptive learning approach, allowing teachers to tailor instruction to the unique needs and learning styles of their students.One of the most significant changes introduced by the New Curriculum Standard is the increased focus on real-world application and interdisciplinary connections. Rather than treating English as a standalone subject, the new standard encourages the integration of language skills with other academic disciplines, such as history, science, and the arts. This approach helps students recognize the relevance of English language proficiency in a wide range of contexts, preparing them for the diverse challenges and opportunities they will encounter in their academic and professional pursuits.Furthermore, the New Curriculum Standard places a greateremphasis on the development of social-emotional learning (SEL) skills. Recognizing the importance of emotional intelligence and interpersonal competence, the curriculum incorporates activities and lessons that foster self-awareness, empathy, and effective communication. By nurturing these essential life skills, the standard aims to produce well-rounded individuals who are not only academically proficient but also equipped to navigate the complexities of the modern world.The implementation of the New Curriculum Standard for High School English is not without its challenges. Educators must navigate the transition from the previous curriculum, adapting their teaching practices and resources to align with the new standards. Additionally, the successful implementation of the standard requires a significant investment in professional development, ensuring that teachers are equipped with the necessary knowledge and skills to effectively deliver the revised curriculum.Despite these challenges, the potential benefits of the New Curriculum Standard are vast. By equipping students with a more comprehensive and adaptable set of language and critical thinking skills, the standard prepares them for the demands of higher education, the workforce, and the ever-changing global landscape. The emphasis on digital literacy, interdisciplinary connections, and social-emotional learning further enhances students' ability tonavigate the complexities of the 21st century, positioning them for long-term success and personal fulfillment.As the New Curriculum Standard for High School English continues to be implemented across the education system, it is essential that all stakeholders – including educators, policymakers, and the broader community – work collaboratively to ensure its effective and equitable rollout. By embracing this new standard, we can empower the next generation of learners to become confident, adaptable, and engaged citizens, poised to make meaningful contributions to the world around them.。
工艺技术人员的英文单词
工艺技术人员的英文单词Craftsmen in TechnologyIn today's rapidly evolving world, technology plays an integral role in every aspect of our lives. From the moment we wake up until the moment we go to bed, technology is constantly at our fingertips. However, behind the scenes, there is a group of individuals who work tirelessly to ensure that technology operates smoothly and efficiently: craftsmen in technology.Craftsmen in technology, also known as technical artisans, are skilled professionals who specialize in various fields of engineering and technology. Their work encompasses a wide range of responsibilities, including design, development, implementation, and maintenance of technological systems.One of the key roles of craftsmen in technology is to design and develop new technologies. They use their knowledge and expertise to create innovative solutions that can improve efficiency, productivity, and overall performance. Whether it's developing new software, designing advanced hardware, or implementing cutting-edge technologies, craftsmen in technology are at the forefront of technological advancements.In addition to design and development, craftsmen in technology are also responsible for implementing and maintaining technological systems. They work closely with other professionals, such as IT specialists and engineers, to ensure that systems are installed correctly and function properly. They troubleshoot problems, perform repairs, and upgrade systems to keep up with the latesttechnological advancements.Craftsmen in technology often possess a wide range of skills and knowledge in their respective fields. They are proficient in programming languages, such as Java, Python, and C++, and have a deep understanding of computer hardware and networking. They are also familiar with various software and tools used in their industry, enabling them to perform their jobs efficiently.Furthermore, craftsmen in technology must possess strong problem-solving and analytical skills. They encounter technical challenges on a daily basis and must be able to think critically and creatively to find solutions. They are constantly learning and updating their skills to keep up with the ever-changing technological landscape.Craftsmen in technology are often employed in various industries, including manufacturing, telecommunications, healthcare, and finance, among others. They can work for large corporations, startups, or as freelancers. Some craftsmen in technology also choose to specialize in specific areas, such as artificial intelligence, cybersecurity, or robotics.In conclusion, craftsmen in technology play a vital role in our modern society. They are the driving force behind technological advancements and ensure that technology operates smoothly and efficiently. Their skills and expertise are essential for the development and maintenance of technological systems. In a world increasingly dependent on technology, craftsmen in technology arethe unsung heroes behind the scenes, making our lives easier and more convenient.。
闽教英语月考简报范文
闽教英语月考简报范文The Fujian English Monthly Examination Report serves as a comprehensive overview of the performance and progress of students in the English language learning process. This report provides valuable insights into the strengths, weaknesses, and areas for improvement, enabling educators and administrators to make informed decisions and implement targeted strategies to enhance the overall quality of English education within the Fujian province.The report begins by highlighting the overall performance of students across various grade levels and proficiency benchmarks. It presents a detailed analysis of the examination results, showcasing the percentage of students who have achieved or exceeded the expected learning outcomes. This data serves as a crucial indicator of the effectiveness of the teaching methods and the alignment of the curriculum with the students' learning needs.One of the key aspects of the report is the examination of the specific language skills assessed during the monthly tests. This includes an in-depth analysis of the students' performance in areassuch as reading comprehension, writing, listening, and speaking. By delving into the nuances of each skill, the report provides educators with a comprehensive understanding of the students' strengths and weaknesses, enabling them to tailor their instructional approaches accordingly.Furthermore, the report explores the impact of various factors on the students' English language proficiency. This includes an examination of the socioeconomic backgrounds, learning environments, and teaching methodologies employed in different schools and regions within the Fujian province. By identifying the correlations between these factors and the students' academic achievements, the report serves as a valuable tool for policymakers and school administrators to implement targeted interventions and resource allocations.The report also highlights the progress and growth of individual students over the course of the academic year. By tracking the students' performance across multiple monthly examinations, the report provides a longitudinal perspective on their language development. This information is crucial for identifying patterns of progress, pinpointing areas that require additional support, and recognizing the students who have demonstrated exceptional growth, thereby enabling educators to provide personalized guidance and support.One of the key strengths of the Fujian English Monthly Examination Report is its emphasis on data-driven decision-making. The report presents a wealth of statistical data and analytical insights, which serve as the foundation for the formulation of strategic plans and the implementation of evidence-based interventions. This approach ensures that the actions taken by educational stakeholders are grounded in empirical evidence, maximizing the potential for positive impact on the students' learning outcomes.Another notable aspect of the report is its focus on the integration of technology in the English language learning process. The report examines the utilization of digital resources, online learning platforms, and interactive teaching tools, and their impact on the students' engagement, motivation, and overall performance. This information is crucial for guiding the integration of technology-based solutions into the English language curriculum, ensuring that the students are equipped with the necessary digital skills to thrive in the 21st-century global landscape.The Fujian English Monthly Examination Report also serves as a platform for the dissemination of best practices and successful strategies employed by individual schools or districts. By highlighting the approaches that have yielded positive results, the report encourages the sharing of knowledge and the adoption of effective teaching methodologies across the province. This collaborativeapproach fosters a culture of continuous improvement and mutual learning, ultimately benefiting the entire educational community.In conclusion, the Fujian English Monthly Examination Report is a comprehensive and invaluable tool for enhancing the quality of English language education in the Fujian province. By providing detailed data, analytical insights, and strategic recommendations, the report empowers educators, administrators, and policymakers to make informed decisions, implement targeted interventions, and drive continuous improvement in the English language learning process. As the province continues to invest in the development of its students' English proficiency, the Fujian English Monthly Examination Report will undoubtedly play a pivotal role in shaping the future of English education and equipping the next generation with the necessary language skills to succeed in the global arena.。
助理经理 英语
助理经理英语The Role and Responsibilities of an Assistant ManagerIn the dynamic world of business, the position of an assistant manager has become increasingly crucial in ensuring the smooth operation and success of organizations. As the right-hand to the manager, the assistant manager plays a multifaceted role that encompasses a wide range of responsibilities. From overseeing day-to-day operations to providing strategic support, the assistant manager is the linchpin that holds the team together and propels the organization forward.One of the primary responsibilities of an assistant manager is to act as a bridge between the manager and the rest of the team. They serve as a conduit for communication, ensuring that information flows seamlessly between the upper echelons of management and the frontline employees. This involves relaying instructions, clarifying expectations, and addressing any concerns or queries that arise. By effectively facilitating this exchange, the assistant manager helps to foster a cohesive and collaborative work environment.Moreover, the assistant manager is often tasked with overseeing the execution of the manager's directives. This includes coordinating the efforts of various team members, delegating tasks, and ensuring that deadlines are met. They must possess a keen eye for detail, the ability to multitask, and strong organizational skills to ensure that every aspect of the operation runs like a well-oiled machine. By taking on these operational responsibilities, the assistant manager frees up the manager to focus on higher-level strategic planning and decision-making.In addition to their operational duties, assistant managers are also expected to provide valuable input and support in the decision-making process. They often have a deep understanding of the day-to-day realities of the business, and their insights can be invaluable in shaping the organization's policies and strategies. The assistant manager may be tasked with conducting research, analyzing data, and presenting recommendations to the manager, thereby contributing to the overall strategic direction of the company.One of the key attributes of a successful assistant manager is their ability to think critically and problem-solve. They must be able to anticipate potential challenges, identify viable solutions, and make informed decisions in the absence of the manager. This requires a strong grasp of the business, an analytical mindset, and theconfidence to take ownership of their actions. By demonstrating their problem-solving capabilities, assistant managers can earn the trust and respect of their colleagues, further solidifying their role as a valuable asset to the organization.Moreover, the assistant manager is often expected to serve as a mentor and coach to junior members of the team. They can leverage their experience and expertise to provide guidance, offer feedback, and help develop the skills and capabilities of their colleagues. This not only benefits the individual team members but also contributes to the overall growth and development of the organization as a whole.In times of crisis or unexpected events, the assistant manager's role becomes even more crucial. They must be able to step up and take charge, making critical decisions and leading the team through challenging situations. This requires a deep understanding of the organization's operations, the ability to remain calm under pressure, and the confidence to make tough choices. By demonstrating their leadership abilities, assistant managers can earn the trust and respect of their colleagues, further cementing their value to the organization.Beyond their day-to-day responsibilities, assistant managers are also expected to contribute to the overall strategic planning and decision-making of the organization. They may be involved in thedevelopment of business plans, the implementation of new initiatives, or the evaluation of existing processes. By providing their unique perspective and insights, assistant managers can help shape thelong-term direction of the company and play a crucial role in its continued success.In conclusion, the role of an assistant manager is multifaceted and essential to the success of any organization. From overseeing day-to-day operations to providing strategic support, the assistant manager is the linchpin that holds the team together and propels the organization forward. By effectively communicating, coordinating, and problem-solving, they contribute to the overall efficiency and effectiveness of the business. Moreover, by serving as a mentor and leader, they help to develop the skills and capabilities of their colleagues, further strengthening the organization as a whole. As the business landscape continues to evolve, the importance of the assistant manager will only grow, making it a critical position for any organization seeking to thrive in the modern era.。
药品生产工艺流程控制方法
药品生产工艺流程控制方法The control of pharmaceutical production processes is crucial for ensuring the quality, safety, and efficacy of medicines. 药品生产工艺流程控制对于确保药品的质量、安全和有效性至关重要。
One method of controlling the pharmaceutical production process is through the implementation of good manufacturing practices (GMP). 通过实施良好的生产规范(GMP)是控制药品生产工艺流程的一种方法。
GMP guidelines provide a framework for ensuring that pharmaceutical products are consistently produced and controlled according to quality standards. GMP指南提供了一个框架,确保药品产品根据质量标准进行一贯的生产和控制。
Another important aspect of controlling the pharmaceutical production process is the use of process analytical technology (PAT).控制药品生产工艺流程的另一个重要方面是利用过程分析技术(PAT)。
PAT involves the monitoring and control of pharmaceutical processes through real-time measurements, which can help to identify and correct any deviations from the desired specifications.PAT涉及通过实时测量来监测和控制药品工艺,有助于识别和纠正与期望规格的任何偏差。
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Implementation and Analytical Model of Three-Phase Four-SwitchPower Factor CorrectorJiri Klima Jiri Skramlik, Viktor Valouch Department of Electrical Engineering and Automation Institute of Thermomechanics Technical Faculty of CZU in Prague Academy of Sciences of the Czech Republic 16627 Prague 6, Czech Republic Dolejškova 5, 182 02 Praha 8, Czech Republic E-mail: klima@tf.czu.cz E-mail: valouch@iee.cas.czAbstract.This paper presents a three-phase four-switch converter aimed at compensating reactive power in case of distorted and unbalanced source voltages. An original closed-form solution of line currents, based on the mixed p-z approach is presented. The analytical and experimental results are provided to verify the effectiveness of the proposed control scheme.Key wordsSV PWM, Four-Switch Converter, AC-DC Power Converters, Power Factor Correction.1. IntroductionAC-DC conversion is used more and more in a wide field of applications. A great attention has therefore been focused recently on the research and development of pulse width modulated rectifiers (PWM rectifiers) [1], [2].It is well known that a three-phase converter can develop various faults. The interruption of the manufacturing or other process due to a PWM rectifier fault would result in financial losses or even in some serious damage. That is why improved reliability, and fault tolerant operation of such systems are welcomed today. In general, when one of these faults occur, the isolation of the fault is preferable, keeping the system in partial operation, instead of shutting down the whole process.The converter topology and operation modes of the component minimized three-phase PWM rectifier supplied from unbalanced source voltage are analysed in the paper as well as the novel strategy of the SVM suggested. Finally, an original closed-form solution of line currents, based on the mixed p-z approach[3], [4], [5] is introduced. The results of simulation and tests done on the component minimized three-phase PWM rectifier connected at the three-phase unsymmetrical mains are shown as well.Fig.1 Three-phase four-switch rectifier2. Topology of converter and mode of operationA circuit diagram of the four-switch rectifier is shownin Fig.1. Three inductors are used to achieve line current filtering and to obtain dc link voltage boost operation. The scheme employs four switches S a1, S a2,S b1, and S b2 and four diodes to generate output voltage. The phase “a” is directly connected to the midpoint of the split dc capacitor.Fig.2 Voltage vector decomposition into two symmetrical sequences: positive V P(n) and negativeV N(n).From the combination of the conduction states of the power switches originate four different vectors in the αβ plane as shown in Fig.2. These vectors are 2/πaway from each other. Additionally, these vectors do not have the same amplitude as in the classical B6 connection. Vectors lying in the real axis have the amplitude of V dc/3, whereas the vectors lying in the imaginary axis have the amplitude of3/dcV3. Let us define the per unite timeε+=n T t , n=0,1,2,.. , 0<ε≤1(1)where T is a period of the modulation (period of the symmetry) and is next called a sector, ε is per unit time inside of sector.The voltage vector V(n) can be expressed by means ofthe discrete Fourier transform in the symmetrical formas follows from [3]:∑−=∑−=π−=1N 0m 1N 0i N 2)m n (ji e)m (V N 1)n (V (2) where N is the number of the vectors used per output period and n is a variable (number of the sector). For the voltage vectors with π/2 symmetry (N=4) weget: 22(1(1()66()()jn jndc dc P N V V V n eeV n V n ππ−+−=+=+=(3)If we use only four voltage vectors, this unsymmetrical sequence (2) can be decomposed into two symmetrical ones (3). The first sequence has a positive direction of rotation with the amplitude 6)31(dc V + and the second sequence has a negativedirection of rotation with amplitude 6)31(dc V −.These negative sequences can be used for elimination of the unbalance input voltage. The situation is shownin Fig. 2 .On the left side we can see unsymmetrical sequence of the four-switch converter. The reference voltage V AV has a polar angle ρ to the real axes.3. Space-vector PWMTo control the transient responses of the linecurrents ,, precisely, the four-switch rectifier in Fig. 1 has to be operated as a Pulse Width Modulated (PWM) rectifier. By using a proper PWM strategy, the line currents will be able to follow their reference values with small errors. The higher the switching frequency will be applied, the lower the errors will appear. The line currents are determined by the voltage drops at the ac inductors (, ). If the line voltage vector is measured, the reference of the rectifier ac-terminal voltage vector may becalculated by using the inductor parameters , and the reference of the line current vector as follows: Sa i Sb i Sc i S L S R S v *v S L R S *S i *S S S d d R L t ⎛−+⎜⎝⎠v =v i *S ⎞⎟ (4)We have proposed a new Space Vector Modulation (SVM) strategy for the three-phase four-switch rectifier in Fig.1. 4. Closed-form solution If the four-switch rectifier is operated as the PWM rectifier with the SVM strategy mentioned in the previous chapter, expression (3) must be modified to respect the switching intervals. If ε (p.u.) is the time inside every sector, the voltage vector may be defined as follows [5]:(5) With regard to the SVM strategy mentioned, we getafter using the Laplace transform i S *(p)= N PA ,k,xB ,k,x 1S S A ,k,x B ,k,2j j p T 3N 2d c 1R p L k 1x 1p T j (k)j(x 1)p T p T 2p T j e ))V (1(6e e e (e e (e e )πϕϕ−εε+==π−α−−−ε−ε−π−+−+−−∑∑x )) (6)where k=1,2,..3N 1 and x=1,211(1)32()122611(1)32()122611(,)(,)(,)(1(,,)(1(,,)P N x N j k j jn dc x N j k j jn dc k x n n n V f k x e e e V f k x e e e παπππαππεk x εεεε−===+=−−−−==++∑∑V ∑∑V VThe solution in the time domain contains both the steady-state and the transient parts. As our attention is the steady-state solution we can get for n→∞the closed-form solution.5. Analytical and experimental resultsTo confirm the validity and effectiveness of the proposed analytical method, the closed form analytical and experimental results are presented.To compare also the influence of the high frequency ripple in the phase currents, Fig. 3 shows the simulated phase current (in p.u.) with its ripple waveform.Fig.3 One period of the phase line currentThe detail of one period of the measured line current i Sa and its harmonic spectrum is presented in Fig. 4.Fig. 4 Experimental results. Detail of one period and harmonic spectrum of line current i SaFig. 5 Experimental results. Three phase line currentsi Sa,i Sb,i S c Fig.5 shows captured time responses of all three line currents i Sa, i Sb, i Sc. From Fig.4 we can see that phase currents are symmetrical and in high correlation with analytical results in Fig 3.Fig.6 Experimental results. Grid phase voltage, andtwo line currentsIn Fig.6 we can see the time responses of the source voltage with the line current, in the phase “b”, together with the current in the phase “a”. The responses have been reconstructed from the data captured and used by the controller. It is evident that the line voltage and current are actually in the phase.6. ConclusionA three-phase four-switch converter based on a new space-vector PWM strategy is analytically investigated. The scheme with a reduced number of power switches, improving the rectifier efficiency, can compensate the unbalanced source voltages. The analytical results and experiment tests on the component minimized three-phase PWM rectifier connected at the three-phase unsymmetrical mains are shown as well to demonstrate the validity and effectiveness of the proposed control scheme.References[1] Ohnishi, T., Okitsu, H.: A Novel PWM Technique for Three Phase Inverter/Converter. Proc. Of Int. Conf. IPEC’83, Tokyo, Japan, 1983, pp. 384-395[2] Malinowski, M., Kazmierkowski, M.P.: Controlof Three-Phase PWM Rectifiers. In Kazmierkowski, P.M., Krishnan, R., Blaabjerg, F.: Control in Power Electronics. Academic Press, Elsevier Science (USA), 2002.[3] Klima,J.: Analytical closed-form solution of a space-vector modulated VSI feeding an induction motor drive.IEEE Transaction on Energy Corversion,vol.17,No2,June 2002,pp.191-196[4] Klima,J: Mixed p-z approach for time-domain analysis of voltage source inverters with periodic pulsewidth modulation. IEEE Transaction on Circuitsand Systems II. 2004, No.10, October,ISSN 1057-7130,pp.529-536[5] Klima,J.: Time and frequency domain analysis ofa fault-tolerant space vector PWM VSI-fed induction motor drive.IEE Proceedings-Electric Power Applications,Vol.152,No4,2005, ISBN 1350-2352,pp.765-775 AcknowledgementThe financial supports of the Academy of Sciences of the Czech Republic (Institutional Research Plan Z20570509 of the Institute of Thermomechanics) and of the Grant Agency of the Academy of Sciences of the Czech Republic (Project No. IAA200760703) are highly acknowledged.。