Handout.EfficientFrontiers

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挑战新境界的英语作文

挑战新境界的英语作文

Pushing the Boundaries:An English Composition on New FrontiersIn the everevolving landscape of human endeavor,the quest for new frontiers has always been a driving force.The English language,with its rich vocabulary and expressive power,provides an ideal medium for exploring and articulating the challenges and triumphs of this pursuit.This composition delves into the concept of challenging new frontiers,both in the literal sense of physical exploration and in the metaphorical sense of personal and intellectual growth.The Physical Frontier:Exploration and DiscoveryThe physical frontier has historically been associated with geographical exploration. From the Age of Discovery,when European explorers ventured into the unknown,to the modern era of space exploration,humanity has always been drawn to the edges of the map.English,as a global language,has played a pivotal role in documenting these journeys.For instance,the diaries of Christopher Columbus and the Apollo mission transcripts are all written in English,showcasing the languages ability to capture the awe and wonder of new discoveries.The Technological Frontier:Innovation and ProgressIn the realm of technology,English has become the lingua franca for innovation.The language of coding,programming,and software development is predominantly English, enabling a global community of tech enthusiasts and professionals to collaborate and push the boundaries of what is possible.From the development of the internet to advancements in artificial intelligence,English serves as the common ground for sharing ideas and breakthroughs.The Intellectual Frontier:Expanding Knowledge and UnderstandingThe intellectual frontier is perhaps the most profound of all.It encompasses the pursuit of knowledge in various fields such as science,philosophy,and the arts.English,with its extensive academic literature and research papers,facilitates the dissemination of new ideas and theories.The languages flexibility and precision make it an ideal tool for academic discourse,enabling scholars to challenge established norms and propose new paradigms.The Personal Frontier:SelfDiscovery and GrowthOn a more personal level,challenging new frontiers can mean overcoming personallimitations and achieving selfimprovement.English,with its expressive capabilities, allows individuals to articulate their aspirations,fears,and triumphs.Autobiographies, motivational speeches,and selfhelp books written in English inspire countless people to embark on their own journeys of selfdiscovery.The Cultural Frontier:Bridging Diverse PerspectivesCultural exploration is another dimension where English plays a significant role.As a language spoken in various parts of the world,it serves as a bridge between different cultures,allowing for the exchange of ideas and the appreciation of diverse perspectives. English literature,cinema,and music often reflect this cultural diversity,enriching the global community and fostering a deeper understanding of different ways of life.ConclusionIn conclusion,the concept of challenging new frontiers is multifaceted and can be approached from various angles.English,with its versatility and widespread use,is an indispensable tool in this endeavor.Whether it is through the documentation of physical exploration,the advancement of technology,the pursuit of intellectual knowledge, personal growth,or cultural understanding,English enables us to express,share,and celebrate the human spirits relentless quest for new horizons.。

前台练习题

前台练习题

前台练习题一、基础知识类1. 请简述前台的职责范围。

2. 前台接待礼仪中,如何正确使用电话沟通?3. 解释什么是5S管理,并说明其在前台工作中的应用。

4. 请列举三种前台工作中常用的办公软件。

5. 前台在处理客户投诉时应遵循哪些原则?6. 请描述前台接待客人时的基本流程。

7. 如何正确记录和传达客户的留言?8. 前台在处理突发事件时应如何应对?9. 请简述前台在处理快递和邮件时应注意的事项。

10. 请列举五种提高前台工作效率的方法。

二、沟通技巧类1. 如何运用非语言沟通技巧提高前台服务质量?2. 请举例说明如何运用同理心技巧与客户建立良好关系。

3. 在前台接待中,如何运用提问技巧引导客户?4. 请描述如何运用倾听技巧提高前台服务质量。

5. 如何运用正面语言技巧化解客户不满?6. 请列举三种提高前台沟通效果的身体语言。

7. 在前台接待中,如何运用幽默技巧缓解紧张气氛?8. 如何运用沉默技巧在适当的时候给客户留下思考空间?9. 请描述如何运用反馈技巧确保客户需求得到满足。

10. 如何运用确认技巧确保双方沟通无障碍?三、客户服务类1. 请简述前台在客户服务中的重要作用。

2. 如何根据客户需求提供个性化服务?3. 请列举三种提高客户满意度的方法。

4. 如何正确处理客户投诉?5. 请描述前台在处理客户意见反馈时应注意的事项。

6. 如何运用客户关系管理(CRM)系统提高前台服务质量?7. 请简述前台在客户服务中的危机应对策略。

8. 如何通过前台服务提升企业品牌形象?9. 请列举三种前台在客户服务中常用的沟通技巧。

10. 如何在客户服务中运用团队合作精神?四、突发事件处理类1. 请描述前台在遇到突发火灾时应如何应对。

2. 如何处理客户突然晕倒的情况?3. 请列举三种前台在处理突发事件时应遵循的原则。

4. 如何在突发事件中保持冷静和专业的态度?5. 请描述前台在遇到停电时应如何应对。

6. 如何处理客户在前台发生争吵的情况?7. 请简述前台在遇到恐怖袭击时应如何应对。

江苏省南通市海安市2024-2025学年高三上学期开学英语试题

江苏省南通市海安市2024-2025学年高三上学期开学英语试题

2025届高三期初学业质量监测试卷英语第一部分:听力(共两节,满分30分)第一部分:听力(共两节,满分30分)第一节(共5小题;每小题1.5分,满分7.5分)听下面的5段对话。

每段对话后都有一个小题,从题中所给的A、B、C三个选项中选出最佳选项。

听完每段对话后,你都有10秒钟的时间来回答有关小题和阅读下一小题。

每段对话仅读一遍。

1.Why is the woman making changes?A.To work at the office.B.To follow her dream.C.To go to university.2.Where does the conversation probably take place?A.In a taxi.B.In a train station.C.In the speakers’ home.3.Why does Geoff think it was a bad start?A.He mistook the woman’s identity.B.He didn’t help the receptionist.C.He was late for work.4.What time is Cathy’s interview?A.At 2:00 p.m.B.At 3:00 p.m.C.At 4:00 p.m.5.What does the man want to do?A.Repair the roads.B.Cut back the trees.C.Examine the bird boxes.第二节(共15小题;每小题1.5分,满分22.5分)听下面5段对话或独白。

每段对话或独白后有几个小题,从题中所给的A、B、C三个选项中选出最佳选项,并标在试卷的相应位置。

听每段对话或独白前,你将有时间阅读各个小题,每小题5秒钟;听完后,各小题将给出5秒钟的作答时间。

高二英语科技前沿动态单选题50题

高二英语科技前沿动态单选题50题

高二英语科技前沿动态单选题50题1. The new technology enables us to communicate ______ than ever before.A. more easilyB. most easilyC. easierD. easy答案:A。

本题考查副词比较级的用法。

“than”是比较级的标志,A 选项“more easily”是“easily”的比较级形式,符合语法规则;B 选项“most easily”是最高级形式,不符合语境;C 选项“easier”是形容词比较级,此处需要副词修饰动词“communicate”;D 选项“easy”是形容词原级,不能与“than”连用。

2. The development of 5G technology has brought ______ changes to our lives.A. a great deal ofB. a number ofC. the number ofD. a lot答案:B。

本题考查短语的用法。

A 选项“a great deal of”修饰不可数名词;B 选项“a number of”修饰可数名词复数,表示“许多”,符合“changes”(可数名词复数);C 选项“the number of”表示“……的数量”;D 选项“a lot”需要加“of”才能修饰名词。

3. The latest smart phone has a ______ camera that can take amazing pictures.A. high-resolutionB. high-resolvingC. highly-resolutionD. highly-resolving答案:A。

“high-resolution”是一个复合形容词,表示“高分辨率的”,B、D 选项的形式错误,C 选项“highly-resolution”的表述不正确。

frontiers的scope statement模板 -回复

frontiers的scope statement模板 -回复

frontiers的scope statement模板-回复Frontiers的scope statement模板:在现有的研究中提供专门领域的综合性期刊,以支持创新科学研究的发展和对全球挑战的解决。

【Frontiers的scope statement表明其目标是提供综合性期刊,以促进创新科学研究的发展和全球挑战的解决。

下面将逐步回答这个主题,深入了解Frontiers的背景、服务以及其对科学研究的影响。

】第一步:介绍Frontiers的背景和目标(大约300-400字)Frontiers是一家于2007年成立的开放获取出版商,旨在支持创新科学研究的发展并推动全球挑战的解决。

Frontiers通过提供综合性期刊的平台,为科学界和学术界的研究人员提供了一个交流和分享他们的研究成果的环境。

Frontiers的目标是成为一家开放、透明和创新的出版商,为研究人员提供高质量的科学出版服务。

第二步:阐明Frontiers的服务和期刊范围(大约600-800字)Frontiers提供了一个多学科的综合性期刊平台,涵盖了科学、技术、医学、人文和社会科学等各个领域。

Frontiers的期刊范围十分广泛,包括了生物学、化学、物理学、地球科学、工程学、计算机科学、神经科学、医学、健康科学、环境科学、社会科学和人文学等领域。

在每个领域中,Frontiers有专门的领域编辑和编委会,以确保对投稿文章的质量和专业评审。

Frontiers的服务模式是以作者为中心的,注重推动开放科学,并秉持着开放共享和透明的原则。

Frontiers的期刊采用同行评审的方式,以保障稿件的质量和科学正确性。

除此之外,Frontiers还提供研究学者社区、科学咨询和专利服务等支持,以帮助研究人员更好地推动他们的科学研究。

第三步:探讨Frontiers对科学研究的影响(大约600-800字)Frontiers的综合性期刊平台为科学研究提供了一个开放、透明和创新的环境,对科学研究的发展和进步产生了积极的影响。

高二英语Fact-and-fantasy-2

高二英语Fact-and-fantasy-2

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[单选]免疫荧光显微技术中,特异性最高,非特异性荧光染色因素最少的方法是()A.直接法B.间接法C.补体结合法D.双标记法E.多标记法 [填空题]进入工作岗位()穿戴齐全。 [单选,A1型题]诱导免疫耐受的方法是()A.切除成年动物的胸腺B.切除成年动物的脾脏C.注射佐剂D.注射极大量AgE.注射有丝分裂素和Ag [单选]温标有华氏温标、摄氏温标以及()。A、基本温标B、通用温标C、标准温标D、开氏温标 [单选]在销售策略方面,我国基金销售的渠道以()为主。A.基金公司直销B.独立第三方销售公司C.银行和券商代销D.互联网金融渠道 [判断题]数据实时镜像功能的实现采用的是硬件技术。A.正确B.错误 [单选,A2型题,A1/A2型题]女性雌激素的作用不包括()A.乳房发育B.外阴发育C.体毛过多D.子宫发育E.卵巢发育 [单选]可行性研究是工程建设项目决策前运用多种科学成果进行()的综合性学科。A.财务论证B.社会论证C.经济论证D.技术经济论证 [单选]采掘工作面的进风流中,氧气浓度不低于20%,二氧化碳浓度不超过()A.0.75%B.0.5%C.1.5% [名词解释]工具型地理信息系统 [单选]子宫颈癌复发时最为少见的是()A.不规则阴道流血B.下肢水肿C.坐骨神经痛D.肾盂积水E.腹水 [单选]港口与航道工程施工总承包一级资质企业,企业有职称的工程技术人员不少于()人。A.50B.100C.150D.250 [单选]指出不是右肺中叶不张的X线表现()。A.右心缘第二弓消失B.水平叶间裂下移C.底向前下方呈三角形D.位于心后与脊柱重叠E.三角形影尖端指向肺门 [单选]Smith骨折的典型移位是()A.远侧端向掌侧、尺侧移位B.远侧端向尺侧移位C.远侧端向桡、背侧移位D.近侧端向背侧移位E.近侧端旋转移位 [单选,A2型题,A1/A2型题]原核细胞型微生物的结构特点是()A.无核膜核仁B.有核膜核仁C.有完整细胞器D.有染色体E.以上都不是 [单选]下列对于性病性淋巴肉芽肿的诊断有意义,但除了()A.有不洁性交史或配偶感染史B.衣原体培养阳性C.男性龟头、包皮处可见小丘疹、疱疹,无自觉症状D.低丙种球蛋白血症 [填空题]真正的客户服务是根据客户()使他获得满足,而最终使客户感觉到他受到重视,把这种好感铭刻在他的心里,成为企业的忠实的客户。 [单选,A1型题]关于清热药主要药理作用叙述错误的是()A.抗病原微生物B.抗毒素C.发汗D.解热E.抗炎 [问答题,简答题]励磁变容量、电压比? [单选,A2型题,A1/A2型题]下列肾功能监测的指标中,临床很少应用的是()A.肾小球滤过率(GFR)B.血尿素氮(BUN)C.血肌酐(Cr)D.肾血流量测定E.肾小管功能测定 [单选,A2型题,A1/A2型题]下列可引起局部水肿的是()。A.黏液性水肿B.丝虫病C.重度烧伤D.肾病综合征E.肝硬化 [配伍题,B1型题]发生在输血2小时内最常见的并发症是()</br>输血的同时输注低渗性液体易发生()A.变态反应B.发热反应C.过敏反应D.溶血反应E.细菌污染反应 [单选]脑血管疾病所致精神障碍的主要情感障碍是()。A.情感脆弱B.情感淡漠C.抑郁D.焦虑、紧张E.情感易激惹 [单选,A2型题,A1/A2型题]确诊肺癌最可靠的依据是()A.胸部X线检查B.痰细胞学和纤维支气管镜检查C.胸部CT检查D.放射性核素肺扫描E.病史、体征 [单选]中版海图水深大于31m的,水上注记注至()。A.0.1mB.0.5mC.整米D.1cm [单选]()在建筑防火检查中,通过对建筑装修和外保温系统的检查,可以降低建筑的火灾荷载,从而有效地控制建筑失火的几率。A.建筑使用管理单位B.建筑内部装修单位C.建筑施工单位D.建筑设计单位 [单选]人工砂的总压碎值指标应小于()。A.10%B.20%C.30% [填空题]电气设备的绝缘水平是指该电气设备能承受的() [名词解释]自然选择 [判断题]在倾斜井巷中使用的钢丝绳,其插接长度不得小于钢丝绳直径的1000倍。A.正确B.错误 [单选]按订单或出库单的要求,从储存场所选出物品,并放置在指定地点的作业是()。A.分货B.拣选C.流通加工D.保管 [单选]下列()属于会计信息的内部使用者。A.投资者B.社会公众C.企业总裁D.政府部门 [名词解释]非法阻挡(HOLDING) [单选]行政诉讼所要解决的行政争议,是()之间发生的法律争议。A.行政机关B.行政机关与行政机关工作人员C.国有企业事业单位与职工D.行政主体和行政相对人 [单选]采用特细砂配制商品混凝土时,以下措施中哪一项是不可取的?()A、采用较小砂率B、适当增加水泥用量C、采用较小的坍落度D、掺减水剂 [单选]临床上化妆品眼损害大多是由于()。A.眼部皮肤黏膜特别敏感B.用于眼部的化妆品刺激性较强C.非眼部化妆品误入眼内D.不正确使用眼部化妆品E.眼部化妆品的使用频繁 [单选,A1型题]中兽医学的指导思想是()A.脏腑学说B.经络学说C.阴阳五行学说D.辨证论治E.八纲辨证 [单选]核素显像技术的优势是()A.影像分辨率高B.价格便宜C.可显示脏器功能D.无辐射损害E.可断层显像 [问答题]一架装载如下的飞机的地板的最小承载限制是多少?货盘尺寸-长39宽37货盘重量-37磅系留装置-54磅货物重量-1,094.3磅 [判断题]银行卡按发卡对象分可分为贵宾卡和普通卡。A.正确B.错误

Topic Overview -Student Handout

Topic Overview -Student Handout

/2015/01/pf-feb-2015-economic-globalization.html#Resolved: On balance, economic globalization benefits worldwide poverty reduction.Introduction This is potentially a very interesting topic. Given that ECONOMIC globalization refers to a kind of ECONOMIC interdependency between nations, we could explode the grounds of debate and discuss a myriad of contentions including the impact of globalization on security,the impact on health, the impact on the environment, the impact on the balance of power and world politics, the impact on the role or multinational corporations on world politics, and of course, the impact on worldwide poverty. The RESOLUTION founders have chosen to limit the grounds to the impact on worldwide poverty. So, while Pro will be laying out a case which very pragmatically describes how globalization is the single most important mechanism in the history of the universe to solve poverty, and reap all of its enormous inherent advantages; Con may very well explode the debate with every single negative impact every witnessed as a result of globalization, so long as it somehow links to poverty. After all, what good is reducing poverty if it means the world is more polluted, there are even less fossil fuels to go around, new and exotic diseases are more easily spread, and so on, ad-infinitum. Conversely, the Pro can take a similar route and link a plethora of potential benefits to poverty. After all, the poor are helped when the chances or war are reduced, or when infrastructure is created, or when services are upgraded and personal wealth increases. Whew...just how much work will the well-prepared debaters have to do to turn all these potential impacts?/2015/01/pf-feb-2015-economic-globalization.html#Defining the ResolutionWe need to look at the intent and meaning of the resolution in order to extract the topical grounds.On balanceThis is common debate vernacular which in essence, instructs the debaters and judges to assign relative WEIGHTS to benefits and harms and then determine which way the balance beam tilts. By stating, on balance, there is an implicit acknowledgement that both sides have merit. In other words, we admit there are harms and there are benefitsbut when we objectively examine these claims on the basis of some kind of comparative framework, we will find that one side's impacts outweigh the other side's impacts. We just need to be aware of what it is we need to weigh. More on this in a future post.ECONOMIC globalizationWhen a thing is globalized it is extended throughout the world. Now in terms ofeconomies, internally, each nation has its own economy which we can loosely define as a system for producing and consuming goods and services. When the system of producing and consuming extends across the border of other countries and the two economies become interdependent, the process of globalization increases./2015/01/pf-feb-2015-economic-globalization.html#Shangquan 2000:Economic globalization refers to the increasing interdependence of world economies as a result of the growing scale of cross-border trade of commodities and services, flow of international capital and wide and rapid spread of technologies. It reflects the CONTINUING expansion and mutual integration of market frontiers, and is an irreversible trend for the economic development in the whole world at the turn of themillennium. The rapid growing significance of information in all types of productive activities and marketization are the two major driving forces for economic globalization. In other words, the fast globalization of the world’s economies in recent years is largely based on the rapid development of science and technologies, has resulted from the environment in which market economic system has been fast spreading throughout the world, and has developed on the basis of increasing cross-border division of labor that has been penetrating down to the level of production chains within enterprises of different countries. [page 1]There are a lot prerequisites to allowing economies to interconnect. There needs to be peace, trade agreements, political agreements, agreements on the value of goods and services, communication between the parties, an infrastructure for delivering good and services. And, as stated by the following author one cannot underestimate the impact of multinational corporations./2015/01/pf-feb-2015-economic-globalization.html#Prakash 1999:There is much confusion on what exactly globalization is, how to measure it, who caused it, and how it may impact human existence. I propose the following definition of economic globalization: it is a set of processes leading to cross-border integration of factor, intermediate products, and final products MARKETS along with an increasing salience of multinational corporations in economic activity. Three aspects of this definition are noteworthy. First, globalization is best viewed as a set of processes and not as an end state. Second, cross-border economic integration now spans products andcommodities that are at various stages of the value-addition processes. Third,multinational corporations are the main agents of economic integration. In fact, I would submit that the main difference between globalization now and the previous phases of economic integration is the increasing role of multinational corporations.[page 1]I suppose it is also important to note, both sides must have something to gain which outweighs any inherent difficulties or harms. Therefore, if we acknowledgethat ECONOMIC globalization is taking place, we acknowledge that the parties involved presumably have something to gain from the exchange./2015/01/pf-feb-2015-economic-globalization.html#benefitsRemember, in the context of this resolution, benefits is a verb and not a noun. So if we can define the noun, benefits, as good or helpful outcomes, we could describe the verb, benefits, as actions which result in good or helpful outcomes. Now that may not seem significant and on many levels it is not so significant except to say that if there is an action, there must be an agent to take the action and in this case it is economic globalization which takes the actions which result in good outcomes. Based on these semantics, Con can potentially constrain Pro to only allow direct links between good outcomes and economic globalization. In other words, Pro cannot claim that security, or political stability, or other kinds of "agents" which produce good outcomes should be evaluated in the debate. However, I do think it will be a very, very difficult tactic for Con to undertake.worldwideOne can easily understand that worldwide means extending throughout the world. I think it would be silly to take this term too literally and make the claim there are many places, like, uh mm, North Korea or Somalia which have not benefited so therefore we should vote Con. For me it is not unreasonable to limit the discussion to the countries throughout the world which are actively engaged in legitimate economic exchange with other other countries, rather than isolated economies cut-off by economic sanctions or those which are perhaps considered, failing states. On the other hand, I think Con can make very compelling arguments that in some cases, these isolated or failed states are in some ways the result of economic globalization./2015/01/pf-feb-2015-economic-globalization.html#poverty reductionPoverty is one of those things that is hard to define but you pretty much know it when you see it. Technically, we can say poverty is a state of being extremely poor or living below some socially accepted standard of living. Therefore, poverty is a very difficult standard to globalize except in the most general of terms. So, if we can't sufficiently define what poverty is, how do we know if it is reduced? well, let's start with the idea that reduced means fewer people are in the condition we describe as "in poverty" and for the determination of what is the socially accepted standard of living we must consider these standards on a case by case basis relative to the local conditions of a single nation or state or city or community. Generally speaking we can say if one can not adequately provide sustenance for oneself or family, or one may die unnecessarily or prematurely due to a lack of provisions widely available to other members of the society, then one is living in poverty./2015/01/pf-feb-2015-economic-globalization.html#Barder 2009:There is a healthy debate about how to achieve poverty reduction in developingcountries, but not enough discussion of what we mean by “poverty reduction.” “Poverty reduction” is often used as a short -hand for promoting ECONOMIC growth that will permanently lift as many people as possible over a poverty line. But there are manydifferent objectives that are consistent with “poverty reduction,” and we have to make choices between them. There are trade-offs between tackling current and future poverty, between helping as many poor people as possible and focusing on those in chronic poverty, and between measures that tackle the causes of poverty and those which deal with the symptoms.[Page 1]The Barder quotation is interesting because we can understand how economicglobalization in the form of economic development (investing in infrastructure, resource extraction, land development, etc.) impacts developing countries. However this debate does not require us to focus solely on developing countries. It is fair to ask, what has been the impact of globalization on those living in poverty in fully developed nations? Is there something inherent in economic globalization which further entrenches and constrains the poor people living in developed nations?/2015/01/pf-feb-2015-economic-globalization.html#Another source describes poverty as being incapable of achieving certain minimal standards regardless of personal income.Kakwani 2006:According to the capability approach, an individual is defined as poor if he or she lacks basic capabilities. What ought these basic capabilities to be? An answer to this question requires value judgments, which must reflect appropriately assessed social priorities. While, there is no universal agreement on what these basic capabilities are, it may still be possible to agree on some basic capabilities. For example, if a person is not able to be wellnourished, adequately clothed and sheltered, and not able to avoid preventable morbidity, then he or she can be classified as deprived of basic capabilities. Those capabilities that relate to health, education, shelter, clothing, nutrition and CLEAN WATER can reasonably be regarded as capabilities that we can agree are basic.[page 1]What it MeansFor most of you, this debate will focus on a fairly narrow examination of benefits and harms arising from economic globalization so I would expect you to be filling your files with evidence supporting either point of view. The fascinating and wide-open potential debate will look at the many advantages and disadvantages of economic globalization and their impacts on the world's poor. In these debates, time frame will play a role because while in the short-term, economic globalization may appear to be the cure forpoverty, in the long term it could lead to a major downturn in fortunes. Conversely, while some may argue the near-term benefits of globalization are marginal at best, the long-term future is bright for those most affected by substandard living conditions. No matter how deeply you want to take it, have fun. I think this is going to be a memorable topic which you will think about often in the coming years.Sources:Barder, O.; What is poverty reduction?; Working Paper 179; Center for Global Development; April 2009; accessed 1/5/2014./files/1421599_file_Barder_Poverty_Reduction.pdfKakwani, N.; what is poverty?; Internation Poverty Center, United Nations Development Programme; Sep 2006; No. 22; accessed 1/5/2014./pub/IPCOnePager22.pdfPrakash, A.; overnance and Economic Globalization: CONTINUITIES and Discontinuities; Paper presented to the United Nations General Assembly, New York, September 30, 1999; accessed 1/5/2014./aseem/ga.pdfShangquan, G.; Economic Globalization: Trends, Risks and Risk Prevention; CDP Backround Paper No. 1; United Nations Committee for Development Policy; accessed 1/5/2014/en/development/desa/policy/cdp/cdp_background_papers/bp2000_1.pdf/2015/01/pf-feb-2015-economic-globalization.html#。

introcellular protein degradation_handout

introcellular protein degradation_handout

The ubiquitin-proteasome pathway: Vital MechanismforIntracellular Protein Degradation[Abstract] The ubiquitin-proteasome pathway is dominant in intracellular protein degradation. It is completed in two stages with three major ubiquitin ligases and a bulky proteasome complex, featuring the formation of polyubiquitin chain on the target proteins. This mechanism is essential in many critical biological process such as cell cycle and signal transduction. Particularly, the regulation of tumor suppressors by ubiquitination reveals potential significance for pathological study and drug design.[Key Words] ubiquitin, proteasome, protein degradation, tumor suppressorFrom the establishment of modern molecular biology people have been fascinated by the massive yet subtle protein expression system that instructed by genetic information and form the basis of all living systems. However, to almost every pathway in cell life, the elimination of certain functional component is as important as their creation, but this mechanism – protein degradation was far from revealed until the recent discovery of ubiquitin system. This review aims to provide a brief introduction of the pivotal functional components in the ubiquitin-proteasome pathway of proteolysis, and we also mention a few frontiers where the discovery of ubiquitin system uncovers new regulation mechanisms, leading to probability of pushing pathological study forward.Components and MechanismsThe plasma membrane critically defines space in living structure into “extracellular” and “intracellular”, between which the protein degradation mechanisms are totally different. Extracellular proteins like immunoglobulin and LDL complex are degraded by the lysosome system, that is, cells engulf waste proteins, form endosomes which are then fused with lysosomes, and then degrade the proteins by various enzymes in the lysosome.However, in this process waste extracellular proteins are always isolated from cytosol by a layer of membrane, so thus they never “enter” cells. The degradation of genuine intracellular proteins is largely performed by the ubiquitin-proteasome system. The mechanism is composed of two stages: the tagging of target proteins by polyubiquitin chains and degradation of the tagged protein executed by proteasomes.A.Stage One: UbiquitinationUbiquitin is a 76-amino acid protein which has remarkable stability against heat treatment.[1] It can covalently attaches to other proteins by forming isopeptide bond with ε-amino group of lysine residues or with amino group of the N-terminal.[2] The golobular protein exists ubiquitously in eukaryotes, and is highly conserved.[3]In the tagging stage, a cascade mechanism involving three ubiquitin-protein ligases enables the fast reaction of proteolysis to cell signals. The ubiquitin-activating enzyme E1 activates ubiquitin by forming a high-energy thioester bond with ubiquitin molecule, consuming energyreleased by ATP hydrolysis. The highly efficient E1 then transfer the ubiquitin moiety to ubiquitin-conjugating enzyme E2, forming E2-ubiquitin intermediate also with thioester bond. The next step depends on different E3 enzymes. For E3s with HECT domain, a third high-energy intermediate substrate-E3-ubiquitin is formed before ubiquitin moiety is transferred to the Cys residue of the substrate protein. For E3s with RING finger domain, ubiquitin is directly transferred to the E3-bound substrate through formation of Ub-E2-E3 complex.[3,4]Of the functional enzymes in this stage, E1 is an efficient enzyme with high turnover compared with the overall ubiquitination process, thus allowing the hierarchical amplification of the degradation signal. The E2s contains many different types, and it is proposed that different E2s, each type interacting with a certain sets of E3s, is specifically regulated and related to certain biological functions, thus the remarkable selectivity and specificity of ubiquitin degradation process. The E3s are divided into two groups with unrelated functional domains, HECT and RING-finger. It is believed that E3s plays an essential role in selectivity of protein degradation by this pathway, for E3s connect the ubiquitin carrier E2s and substrates. For RING-finger containing E3s, recognition of specific protein substrates follow the N-end rule that substrate selection is primarily according to the N-terminal residue and accessibility of a Lys residue for ubiquitin binding.[5]B.Stage Two: Proteasome TargetingThe 26s proteasome is a 2.5MDa large holoenzyme consisted of two subcomplexes. The core particle(CP) contains four 7-subunit rings, of which the two inner β-rings catalyze proteolytic reaction. Attached to one end of the barrel-like CP is the regulatory particle(RP), which contains 6 ATPase subunits and 8 non-ATPase subunits to deubiquitinate and unfold the substrate protein. The N-terminal Thr residue of β-ring is center for proteolysis. Different types of β-ring have different protease activity. Proteins tagged with polyubiquitin chain are targeted for entering proteasome. The products of proteasome are short peptide fragments and monomeric ubiquitin recycled for another proteolytic process[3,4].p27 down-regulation by Skp2: Significance of Ubiquitin-proteasome pathwayThe significance of ubiquitin-proteasome is more than just clear malfunctioned or misfolded protein component in cytosol. Study has shown that many housekeeping cellular processes are under the regulation of ubiquitin-dependent protein degradation, such as cell cycle, signal transduction and transcriptional regulation. It has been shown that concentration of many important regulatory protein, e.g. p53, NF-κB, is regulated by ubiquitination of upstream factors.[3]Here we use the tumor suppressor protein p27 as example to illustrate how cell cycle is controlled by this pathway.p27 is a cyclin dependent kinase inhibitor that inhibits the kinase activity of cyclinE-combined Cdk2 protein, thus functioning as a suppressor of cell cycle. During S and G2 phase, p27 degradation depends on Skp2, the substrate-recognition subunit of SCF Skp2, a type of E3 enzyme that facilitates degradation of p27.[6] The overexpression of Skp2 leads to low level of p27, thus significantly induces the onset of cancer and carcinoma.[7] To give another example, the upstream factor MDM2 decreases p53 concentration by facilitating ubiquitination of p53, and amplification of MDM2 leads to suppress of p53 and potentially causes bladder cancer.[8]This regulatory pathway informs us about the essential role of ubiquitin-proteasome pathway in dosage control of key regulatory proteins in cell cycle(in fact Skp2 is responsible for the degradation of many cell cycle related protein such as p21 and free cyclin E) and also in other biochemical processes including transcription and extracellular signal transduction.In this sense, the understanding of ubiquitin system shows great significance as potential target process in treatment of cancer and other diseases like Parkinsonism. Further study of this pathway can surely provide new perspectives for pathological recognition of these diseases and drug design and reveal to us the subtle mechanism of living system’s self-regulating ability.References[1] Avram Hershko, Aaron Ciechanover, Alexander Varshavsky. The ubiquitin system[J]. Nature Medicine. 2000, 6(10): 1073-1081.[2] Linda Hicke, Rebecca Dunn. Regulation of Mmembrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins[J]. Annu. Rev. Cell Dev. Biol. 2003, 19:141–72.[3] WU Huijuan, ZHANG Zhigang, Ubiquitin-Proteasome pathway and its significance[J]. J Int Pathol Clin Med,2006, 26 (1) : 0007204.[4] Michael H. Glickman, Aaron Ciechanover. The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction[J]. Physiol Rev. 2002, 82: 373-428.[5] Cecile M. Pickart. Mechanisms Underlying Ubiquitination[J]. Annu. Rev. Biochem. 2001. 70: 503–533.[6] Keiko Nakayama et al. Skp2-Mediated Degradation of p27 Regulates Progression into Mitosis[J]. Developmental Cell. 2004, 6: 661-672.[7] Matthias Gstaiger et al. Skp2 is oncogenic and overexpressed in human cancers[J]. PNAS. 2001, 98(9): 5043-5048.[8] Ronald Simon et al. Amplification pattern of 12q13-q15 genes(MDM2,CDK4,GLI) in urinary bladder cancer[J]. Oncogene. 2002,21: 2476-2483.。

危机教会我们创新

危机教会我们创新

142《商业评论》2021年4月SMR 专刊人力资源插图:123R F埃尔斯贝特 ● 约翰逊(Elsbeth Johnson )菲奥娜●默里(Fiona Murray )本文介绍了危机中的创新方法。

常言道,需要乃发明之母。

2020年上半年,随着新冠疫情危机的蔓延,各大组织机构纷纷以比通常状况下要快得多的速度,迈开了创新的步伐。

为了使承载能力翻番,可以同时为两位病人通气,美国密歇根州的急症室团队给呼吸机加装上了一根管子。

中国的科学家们用创纪录的三周时间,就完成了新型冠状病毒的基因测序。

来自英国伦敦、牛津和美国波士顿的多支研究团队在不到两个月的时间里,就研制出了一种候选疫苗,并开始展开测试。

英国国家医疗服务体系(National Health Service )仅用四天时间就建成了一座拥有4,000个床位的医院。

为什么危机之中似乎更有可能产生创新?另外更重要的问题在于,一旦度过危机,组织又该如何维持相似的创新水准?通过对公立和私营组织展开研究,我们确定了刻画危机和推动创新的五种相互依存的143 2021年4月《商业评论》SMR 专刊144《商业评论》2021年4月状况。

● 危机催生了突如其来且真实的紧迫感。

●这种紧迫性促使组织放下所有其他优先事项,专注于唯一挑战,按需重新分配资源。

●有了侧重点和再分配资源以后,现在每个人的工作便是团结起来解决问题,为组织提供新的多元观点和视角。

●紧迫性和侧重点使得在平时会构成“浪费”的行为变得合理化,更多的尝试和学习过程也会得到应允。

●由于危机仅仅是暂时的,因此组织可以在短时间内倾力投入到高强度的工作之中。

领导者可以复用典型的危机状况,作为在非危机时刻激发更高效创新的手段。

不过,这就需要领导者对于每种状况下所牵涉到的问题有更深入的理解。

一、危机催生了突如其来且真实的紧迫感。

严重问题的迫近会带来关键的紧迫感,从而使人集中注意力,激励人们采取行动。

如果缺乏实质性的危机,组织就可以对上述某些状况进行近似化,并获得一些收益——至少它们可以弄清楚,为什么危机能够如此激励人们,而当缺少危机时,人们又会天然地充满惰性。

英语(一)试题及答案

英语(一)试题及答案

英语(一)试题及答案英语(一)试题及答案一、听力理解(共20分)A. 短对话理解(共5小题,每小题1分)1. What does the man want to do?A. Buy a new car.B. Sell his old car.C. Fix his car.D. Borrow money.*Answer: B*2. What is the woman's opinion about the weather?A. It's too hot.B. It's too cold.C. It's just right.D. It's unpredictable.*Answer: D*3. Why is the man late?A. He got stuck in traffic.B. He forgot the time.C. He overslept.D. He had to help a friend.*Answer: A*4. What does the woman suggest the man do?A. Take a break.B. Go to the doctor.C. Work overtime.D. Finish the report first.*Answer: B*5. What is the relationship between the two speakers?A. Colleagues.B. Friends.C. Teacher and student.D. Husband and wife.*Answer: C*B. 长对话理解(共5小题,每小题2分)6. What is the main topic of the conversation?A. A job interview.B. A travel plan.C. A birthday party.D. A business meeting.*Answer: A*7. Why is the woman interested in the position?A. She has experience in the field.B. She likes the company's reputation.C. She needs a job urgently.D. She has a personal connection to the company.*Answer: B*8. What does the man ask the woman to do next?A. Prepare a presentation.B. Wait for a second interview.C. Submit her portfolio.D. Call the HR department.*Answer: B*9. What is the man's impression of the woman?A. He thinks she is overqualified.B. He is impressed with her skills.C. He doubts her commitment.D. He finds her unprepared.*Answer: B*10. When is the woman's availability for the second interview?A. Next Monday.B. Next Tuesday.C. Next Wednesday.D. Next Thursday.*Answer: C*二、阅读理解(共30分)A. 快速阅读(共5小题,每小题2分)Passage 1The article discusses the importance of a balanced diet for maintaining good health.11. What does the article mainly focus on?A. The benefits of a balanced diet.B. The types of food to avoid.C. The role of exercise in health.D. The impact of stress on health.*Answer: A*12. According to the article, what should be included in a balanced diet?A. Only fruits and vegetables.B. A variety of foods from all food groups.C. Mostly carbohydrates and proteins.D. A lot of sugar and fats.*Answer: B*13. What is the purpose of the article?A. To promote a specific diet plan.B. To educate readers on healthy eating.C. To criticize unhealthy food choices.D. To compare different diets.*Answer: B*14. What does the article suggest about the role of vegetables in a diet?A. They should be avoided.B. They are essential for health.C. They can be replaced by fruits.D. They are not necessary if you eat enough protein.*Answer: B*15. What is the author's view on fast food?A. It is a convenient option.B. It is unhealthy and should be limited.C. It can be part of a balanced diet.D. It is the main cause of health problems.*Answer: B*B. 深度阅读(共5小题,每小题4分)Passage 2The passage explores the impact of technology on education and the challenges it presents.16. What is the main topic of the passage?A. The history of education.B. The role of technology in education.C. The challenges faced by teachers.D. The benefits of traditional education methods.*Answer: B*17. According to the passage, what are the potential drawbacks of using technology in education?A. It can be expensive.B. It can lead。

2012职称英语理工阅读理解终极版

2012职称英语理工阅读理解终极版

第一篇Ford Abandons Electric Vehicles1) What have the Ford motor company, General Motor’s and Honda done concerning electric cars?2) According to Tim Holmes of Ford Europe, battery-powered cars3) Which auto manufactures are still producing electric vehicles?4) According to the eighth paragraph, hybrid cars5) Which of the following is true about the hope of car manufacturers according to the last paragraph?1. Ford Abandons Electric Vehicles(理C)1) They have given up producing electric cars.2) Will not be the main transportation vehicles in the future.3) Toyota and Nissan.4) run more miles than petrol driven cars.5) The legislation will allow more low-emission to produced.1.针对电动汽车,通用汽车公司和本田汽车公司采取了_____________。

2.据福特欧洲区的Tim Holmes反应,电池动力汽车________。

3._________等汽车生产商仍在生产电动车。

4.混合动力汽车______________。

5.汽车生产商希望____________。

本科护生跨专业教学模式的应用效果

本科护生跨专业教学模式的应用效果

本科护生跨专业教学模式的应用效果白井双,袁媛,蔡立柏,郭森,李思雨,高兴,底瑞青*郑州大学第一附属医院,河南 450052Application effect of interprofessional education mode for undergraduate nursing studentsBAI Jingshuang, YUAN Yuan, CAI Libai, GUO Sen, LI Siyu, GAO Xing, DI RuiqingThe First Affiliated Hospital of Zhengzhou University, Henan 450052 ChinaCorresponding Author DIRuiqing,E⁃mail:*********************Keywords medical students; undergraduate nursing students; nursing education; interprofessional education; interprofessional learning摘要目的:构建并实施本科护生跨专业教学模式,评价其在教学中的实施效果。

方法:采用便利抽样法选取河南省某医学院校2019级临床医学专业四年级本科生36人及2020级护理专业三年级本科生72人作为研究对象。

根据随机数字表法,按专业及一年级综合测评成绩进行分层随机抽样,随机抽取50%(共36人)的本科护生作为单专业组,其余36名本科护生和36名临床医学专业本科生(共72人)作为跨专业组。

单专业组护生参加常态化教学活动,跨专业组采用跨专业教学模式进行临床实践教学。

课前及课后4周采用沟通和团队工作技能评估工具(CATS)、跨专业合作学习评估量表(学生版)进行调查。

结果:单专业组、跨专业组学生课后CATS得分、跨专业合作学习评估量表(学生版)得分均有明显提高(P<0.01);跨专业组中护生课后CATS得分、跨专业合作学习评估量表(学生版)得分高于单专业组(P<0.05)。

frontiers期刊审稿人意见

frontiers期刊审稿人意见

frontiers期刊审稿人意见亲爱的编辑,您好!我最近在审阅了一篇来自[frontiers]期刊的文章,想和您分享一下我的审稿意见。

这篇文章是关于人工智能在医疗领域的应用,我觉得作者们在研究方法和数据分析方面做得非常出色,但是在文章结构和表达上还有一些可以改进的地方。

下面是我对文章的一些建议:我认为作者在引言部分应该更加明确地阐述研究的目的和意义。

毕竟,读者们阅读这篇文章是为了了解人工智能在医疗领域的应用,所以作者应该在开头就告诉读者这个研究的核心内容是什么。

比如,作者可以这样写:“本文旨在探讨人工智能在医疗领域的应用,以期为医生提供更准确的诊断结果和更有效的治疗方案。

”作者在描述研究方法时可以适当增加一些细节,让读者更容易理解。

例如,作者提到了“通过深度学习算法对医学影像进行分析”,但没有具体说明使用的是哪种深度学习算法。

为了让读者更好地理解这一部分的内容,作者可以补充一些技术细节,比如:“我们使用了卷积神经网络(CNN)对医学影像进行分析,因为它在处理图像数据方面具有很强的能力。

”我觉得作者在讨论实验结果时可以更加生动形象一些。

虽然文章中提到了一些关键的数据点,但是整体上还是显得有些枯燥。

为了提高文章的可读性,作者可以尝试用一些比喻或者类比的方式来描述实验结果。

比如:“我们的模型在诊断肺癌方面的准确率达到了95%,这相当于一位经验丰富的医生在没有任何辅助工具的情况下做出正确诊断的概率。

”在讨论实验局限性时,作者可以更加客观地分析一下可能存在的问题。

毕竟,任何研究都不可能完美无缺,作者应该承认自己研究中的不足之处,并提出未来可能的研究方向。

例如:“尽管我们的模型在某些方面取得了很好的效果,但仍然存在一定的误诊率。

未来的研究可以尝试改进模型的结构或者引入更多的数据源来提高诊断准确率。

”我觉得作者在总结部分可以再次强调一下研究的意义和价值。

毕竟,这篇论文的核心目的就是探讨人工智能在医疗领域的应用,所以在结尾部分应该再次强调这一点。

frontiers先提交摘要

frontiers先提交摘要

frontiers先提交摘要二十一世纪的今天,我们拥有着五彩缤纷的文化信息、高速发展的科技水平以及前所未有的物质基础。

但随之而来的却也出现了各种污染问题:环境污染、交通堵塞等等。

这些都严重影响了我们正常的生活与学习。

在21世纪中我们不得不思考并解决如何保护环境、节约资源和减少对自然的破坏;而我们自身又该如何去做呢?或许大家会觉得非常困难——那么接下来我要告诉你一个好消息:我国已将“低碳”列为战略目标,全民开始关注环保。

因此,我们应从小事做起,养成良好的行为习惯,共同创建绿色校园!当然,我们可能没办法改变整个社会的状况,只希望尽力让周围的环境更加美丽,使我们的生存空间更多一份清新。

于是,我想到了“低碳”。

其实说白了,它就是指较低(相对)的温室气体排放量,和较低(相对)的二氧化碳等气体的排放量。

简单点儿讲,就是减少二氧化碳的排放量。

由于近年来工业迅猛发展,导致大气层中的臭氧层被破坏,造成了极端天气频繁出现,比如龙卷风、沙尘暴……据统计,每年仅北京市就有数百万吨的二氧化碳被释放到空气中,形成酸雨,给人类带来巨大灾害。

而且汽车尾气排放的废气中含有上千种有毒物质,直接危害人类健康。

还有电脑、手机等产品运作时散发的热量,都需要用电,这些电器的耗电量占总用电量的20%左右。

看似微乎其微的电费支出,积累起来便是惊人的数字。

所以,请大家珍惜资源吧!节约用纸,爱护花草树木,拒绝浪费粮食,杜绝一切不必要的垃圾制造者,为保护环境贡献自己的一份力量!生命就像是音乐盒里面的旋律一样在人们不经意间悄无声息地滑过,留下的只有回忆。

而在我们漫长的人生旅途中,除了快乐幸福外,最令人刻骨铭心的莫过于亲情。

父母给予我们生命,把我们抚育成人,教我们走路,陪伴我们度过童年,他们是我们永远的依靠。

俗话说:“父母在,人生尚有来处;父母去,人生只剩归途。

”虽然我们渐渐长大,离开了父母的怀抱,但是我们仍旧感受到父母对我们深沉的爱。

可是,在日常生活中,很多孩子往往忽视了父母的付出,甚至误认为理所当然。

“药”创新—知识管理及分享在制药业的应用

“药”创新—知识管理及分享在制药业的应用

Phillip Phan:约翰·霍普金斯大学凯瑞商学院教授Phillip Phan | 文“药”创新—知识管理及分享在制药业的应用不同企业或机构之间分享知识是一个重要而又复杂的话题。

我想以基于知识的生物制药领域为例,通过和大家分享这个行业面临的困境以及各方为应对挑战所做出的探索和实践,来探讨我们可能通过哪些做法来更好地管理知识、分享知识,从而提高创新的效率。

境以及各方为应对挑战所做出的探索和实践,来探讨我们可能通过哪些做法来更好地管理知识、分享知识,从而提高创新的效率。

专利悬崖根据德勤公司的预测,到2020年,全球们现在常常对不同企业或机构之间如何进行知识分享充满好奇。

如果需要突破国别界限、政治界限、文化界限等和他人做知识分享,这个过程还会变得更加复杂。

今天我想以基于知识的生物制药领域为例,通过和大家分享这个行业面临的困我17“药”创新—知识管理及分享在制药业的应用在医疗健康领域的支出将高达8.7万亿美元,较2015年的7万亿美元增幅24%。

增长的原因我们认为有4个:人口老龄化趋势、新兴市场的增长、医疗改善与进步、不断提高的劳动力成本。

与此同时,全球在医疗上的不平等态势非常突出,以美国和巴基斯坦为例,前者2017年的人均医疗支出达1,1356美元,后者则只有53美元。

如何解决快速增长的医疗支出,以及全球医疗的不平等问题,为国际组织和各国政府提出了挑战。

另据德勤预测,自2017年至2022年,全球范围内生物制药公司的收入将小幅增长6.5%至1.06万亿美元。

其中,新兴经济体将贡献其中相当一部分的收入增长,例如中国在近期有望成为全球生物医药销售收入增速排名第三的国家。

更重要的,我们看到了有一些阻碍生物制药公司销售收入增长的因素。

一方面,来自民众和舆论关于控制医药成本和定价的压力。

为了降低成本,减少支出,价值医疗(或者说是以价值为基础的)付费体系被引入到健康医疗领域,价值成为衡量效率的关键。

高考英语一轮复习 基础考点聚焦 Unit 20 New Frontiers 北师大版选修7-北师大版

高考英语一轮复习 基础考点聚焦 Unit 20 New Frontiers 北师大版选修7-北师大版

Unit 20 New Frontiers话题:科技前沿(New frontier of technology)1.develop vt.开展2.technology n.技术3.advance vt.进步4.robot n.机器人5.replace vt.代替6.emergency n.突发事件7.dial v.拨( 号码)8.adjust v.调整9.design v.设计10.convenient adj.方便的11.rescue vt.援救12.efficient adj.效率高的13.effective adj.有效果的14.relax vt.使放松15.outstanding adj.杰出的16.achievement n.成就17.take care of 照顾18.household robots 家务机器人19.individual needs 个人需要20.keep sb. company 陪伴某人1.Hearing the news, all the students in the classroom jumped with joy.听到这个消息,教室里的所有学生都高兴地跳起来。

2.I will work hard to be admitted to Beijing University, from which Tu Youyou graduated.我会努力学习争取被北大录取,屠呦呦就是从那里毕业的。

3.Some robots have entered families, helping people do some housework.一些机器人已经走入家庭,帮助人们做一些家务活。

学校正在组织科技创新大赛,你想为日常生活中某件物品(如钢笔、书包、鞋子……)设计添加新功能来参赛。

请以“My Magic ______〞为题写一篇英语短文,介绍你的创意。

内容:1.说明设计理由;2.介绍新功能My Magic Water BottleMy magic water bottle will be a replacement of the traditional one which can change the temperature of the inside water automatically according to the changes of the outer environment.There are certain factors I take into account on my new invention. For one thing, traditional water bottle makes it inconvenient for travelers to have a comfortable drink anytime and anywhere. For another, drinking too cold or too hot water does nothing but harm to our health, so my magic water bottle can serve as an assistant or a doctor.The new functions will win my magic water bottle enormous love and popularity. On the one hand, the automatic temperature­controlling system mentioned above can adjust the water temperature. On the other hand, we can set a desirable temperature for the inside water, and what surprises us most is that the water can remain at that temperature for about twenty hours.1.software n.软件2.crew n.全体机组人员3.garment n.衣服4.welfare n.福利5.conflict n.争执;冲突6.digital adj.数字式的7.official n.官员8.colleague n.同事,同僚9.recreation n.消遣;娱乐10.patent n.专利11.boundary n.界限;边界12.phenomenon n.现象13.headline n.大标题14.sneeze vi. 打喷嚏15.autonomous adj.自主的;自治的1.handy adj.方便使用的2.download vt.下载3.update vt.更新4.rescue vt.拯救,救援5.disconnect v.使不连接;切断6.original adj.起初的;最早的7.procedure n.步骤;程序8.correspond vi. 通信;符合9.meanwhile adv.同时10.outcome n.后果,结果11.cure vt.治愈12.wrestle vi. 努力解决;摔跤;搏斗13.fade vi. 逐渐变弱14.press vt.按;压15.dilemma n.困境,进退两难的窘境1.assist vt.帮助;协助→assistance n.帮助;协助→assistant n.助手;助理2.technical adj.技术上的→technique n.技术3.latter n.后者→late adj.迟的→lately adv.最近4.starvation n.饥饿→starve v.挨饿5.equality n.平等→equal adj.平等的v.等于→equally adv.平等地;同样地6.assess vt.评估;评价→assessment n.评价;评估7.donate vt.捐赠;赠送→donation n.捐赠;赠送→donator n.捐赠者8.permanent adj.长久的,永久的→permanently adv.永久地9.permit vt.允许,许可→permission n.允许;准许10.poisonous adj.有毒的→poison n.毒药;毒物11.declare vt.宣告;宣布→declaration n.宣布12.exploration n.探测;探险→explore v.探险;考察;勘查→explorer n.探险家;勘探者13.settler n.移民;殖民者→settle vt.定居;解决→settlement n.定居;解决14.instructor n.指导者;教练→instruct vt.指导→instruction n.介绍[用所给词的适当形式填空]1.The assistant will come to your assistance soon and he will assist you with all the work.(assist)2.He has written a novel consisting of two parts lately and today he was late for work and left the latter part at home.(late)3.In winter, many animals will starve to death if they can’t find enough food. Last year, about 200 animals died of starvation in this area.(starve) 4.Many people have donated to the poor boy before and now some more people will make a donation to him again.With the donated money,he will live better.(donate) 5.These explorers are exploring the area for oil now and their exploration began two years ago.(explore)1.in_advance 提前,预先2.take_over 接收,接收3.give_away 泄露(秘密);赠送4.shortly_after 不久后5.cure_sb.of_sth. 治好某人的疾病;纠正(某人)的(坏习惯)6.come_into_conflict 发生冲突7.click_into 点击进入8.drop_off 下降9.rather_than 而不是10.in_conclusion 总之11.not_to_mention 更不用说12.figure_out 想出;理解;计算出13.get_across 使理解,把……讲清楚14.be_dedicated_to 致力于;献身于15.make_up_for 弥补[选用上面的短语填空]The other day we were informed 1.in_advance that a young man would 2.take_over our company.3.Shortly_after the new manager arrived, he took charge of our company.At the meeting he said that he would try his best to 4.cure_the_company_of the old rules,which caused him to 5 e_into_conflict with some old workers.Luckily,the two sides came to an agreement in the end.1.“by+时间点〞常与完成时连用By the year 2015 ,the clothing industry will have produced new types of material that will remain stainless no matter what you spill on them.【仿写】到这个学期末,我们将学完我们所有的课程。

英语作文my dream翻译

英语作文my dream翻译

My dream is a beacon that guides me through the complexities of life,providing a sense of direction and purpose.It is the aspiration that fuels my passion and determination,pushing me to strive for excellence in all that I do.Here is a translation of my dream into English,highlighting its significance and the steps I am taking to make it a reality.我的梦想是我人生旅途中的一盏灯塔,它指引我穿越复杂的生活,为我提供方向和目标。

它是激发我热情和决心的愿景,激励我在所做的一切中追求卓越。

以下是我的梦想的英文翻译,强调它的重要性和我为实现它所采取的步骤。

1.Identifying My Dream确定我的梦想My dream is to become a renowned linguist,fluent in multiple languages and capable of bridging cultural gaps through effective communication.I envision myself as a key figure in international relations,using my linguistic skills to foster understanding and cooperation among diverse peoples.我的梦想是成为一名著名的语言学家,精通多种语言,能够通过有效的沟通弥合文化差异。

我设想自己成为国际关系中的关键人物,利用我的语言技能促进不同民族之间的理解和合作。

2022年浙江省温州市大学英语6级大学英语六级测试卷(含答案)

2022年浙江省温州市大学英语6级大学英语六级测试卷(含答案)

2022年浙江省温州市大学英语6级大学英语六级测试卷(含答案)学校:________ 班级:________ 姓名:________ 考号:________一、1.Writing(10题)1. Directions: For this part, you are allowed 30 minutes to write a short essay entitled On Over-packaging. You should write at least 150 words following the outline given below:1. 目前许多商品都存在过度包装现象2.这种现象的危害3.你的看法On Over-packaging2. Directions: For this part, you are allowed 30 minutes to write a short essay entitled Should the State Interfere with People's Smoking Habits? You should write at least 150 words following the outline given below.1. 现在许多国家和地区纷纷颁布禁烟法令,禁止公民在餐厅、酒吧、商店、办公场所等吸烟2. 你对禁烟令是支持还是反对,并说出理由Should the State Interfere with People's Smoking Habits?3. Directions: For this part, you are allowed 30 minutes to write a short essay entitled is a Diploma Everything. You should write at least 150 words according to the outline given below.1.目前社会上存在着迷信文凭的现象2.造成这一现象的原因3.我对此的观点4. For this part, you are allowed 30 minutes to write a composition on the topic Wealth and Health. You should write at least 150 words and you should base your composition on the outline (given in Chinese) below:1.有人认为财富比健康重要;2. 也有人认为健康比财富重要;3. 我的观点是:5. 1. 目前在中国,校园安全事故时有发生2.这种现象造成了恶劣的影响3.应该如何杜绝这种现象6. 1. 你是如何得知招生信息的2. 自我推荐并说明选择该校的理由3. 希望得到该校的回复7. Directions: For this part, you are allowed 30 minutes to write a composition on the topic An Impressive Film. You should write at least 150 words following the outline given below in Chinese:1. 简单介绍你最喜欢的一部电影2. 谈谈你对这部电影但感受3. 总结8. Directions: For this part, you are allowed thirty minutes to write all open letter to the major of the city based on the following situation:You should write at least 150 words, and base your composition on the outline given below:1. 1.近年来,本市空气污染情况越来越严重2.你认为造成空气污染的主要污染源在哪里?应该采取哪些措施?3.呼吁所有市民积极行动起来,治理空气污染9. For this part, you are supposed to write a short essay entitled Internet according to the following outline given below in Chinese. The first sentence of each paragraph has been given to you.1. 因特网越来越普遍地进入到我们的学习、工作和生活当中2. 因特网的益处3. 因特网的消极方面InternetInternet has been playing an increasing role in our daily life. ______. Internet has enabled us to do a lot of things more easily and quickly. ______. However, if not managed properly, Internet can create many problems too. ______.All in all, we cannot live without Internet now. ______.10. Directions: For this part, you are allowed 30 minutes to write a short essay entitled My Opinion on College Graduates Working as Village Officials. You should write at least 150 words following the outline given below:1. 这种做法的意义何在?2.这些大学生能给农村带去什么?3.大学生能从中得到什么?二、2.Reading Comprehension (Skimming and Scanning)(10题)11.The torch relay was brought back to the Olympics in Berlin in 1936, the flame lit in Olympia, Greece.A.YB.NC.NG12. Kunz gave up software engineering mainly because he earned less than those in law or business field did.13. Scientists and environmentalists think that global warming can be ______.A.continuedB.improvedC.controlledD.reduced14.The National Hot Dog and Sausage Council say Germany is the birthplace of the hot dog.A.YB.NC.NG15.Pollution: A Life and Death IssueOne of the main themes of Planet under Pressure is the way many of the Earth's environmental crises reinforce one another. Pollution is an obvious example-we do not have the option of growing food, or finding enough water, on a squeaky- clean planet, but on one increasingly tarnished and trashed by the way we have used it so far.Cutting waste and clearing up pollution cost money. Yet time and again it is the quest for wealth that generates much of the mess in the first place. Living in a way that is less damaging to the Earth is not easy, but it is vital, because pollution is pervasive and often life-threatening.Air: the World Health Organization (WHO) says three million people are killed worldwide by outdoor air pollution annually from vehicles and industrial emissions, and 1.6 million indoors through using solid fuel. Most are in poor countries.Water: diseases carried in water are responsible for 80% of illnesses and deaths in developing countries, killing a child every eight seconds. Each year 2.1 million people die from diarrhoeal(痢疾的) diseases associated with poorwater.Soil: contaminated land is a problem in industrialized countries, where former factories and power stations can leave waste like heavy metals in the soil. It can also occur in developing countries, sometimes used for dumping pesticides. Agriculture can pollute land with pesticides, nitrate-rich fertilizers and slurry from livestock. And when the contamination reaches rivers it damages life there, and can even create dead zones off the coast, as in the Gulf of Mexico.Chronic ProblemChemicals are a frequent pollutant. When we think of chemical contamination it is often images of events like Bhopal that come to mind. But the problem is widespread. One study says 7-20% of cancers are attributable to poor air and pollution in homes and workplaces. The WHO, concerned about chemicals that persist and build up in the body, especially in the young, says we may "be conducting a large-scale experiment with children's health".Some man-made chemicals, endocrine(内分泌) disruptors like phthalates(酞酸盐) and nonylphenol-a breakdown product of spermicides (杀精子剂), cosmetics and detergents-are blamed for causing changes in the genitals, of some animals. Affected species include polar bears-so not even the Arctic is immune. And the chemicals climb the food chain, from fish to mammals, and to us.About 70,000 chemicals are on the market, with around 1,500 new ones appearing annually. At least 30,000 are thought never to have been comprehensively tested for their possible risks to people.At first glance, the plastic buckets stacked in the comer of the environmental NGO office look like any others. But the containers are an unlikely weapon in one poor community's fight against oil companies which they say are responsible for widespread ill-health caused by years of pollution. The vessels are used by a network of local volunteers, known as the Bucket Brigade, to gather air samples in neighborhoods bordering oil refineries, as part of a campaign to monitor and document air pollution which they believe is coming from the plants.In South Africa, as m many developing and newly industrialized countries, legislation on air pollution has failed to keep pace with mushrooming industries. So local residents, like many in poor communities around the globe, have faced the problem of investigating their claim that industries on their doorsteps are making them sick.Trade-offBut the snag is that modern society demands many of them, and some are essential for survival. So while we invoke the precautionary principle, which always recommends erring on the side of caution, we have to recognize there will be trade-offs to be made.The pesticide DDT does great damage to wildlife and can affect the human nervous system,A.3 millionB.2.1 millionC.1.6 millionD.3.2 million16. Vioxx showed no connection to heart problems in its clinical trial.17.Scientific research and the ______ continue to drive our search for ever more accuracy in time.18.The book The Play of Power mainly focuses on civil rights.A.YB.NC.NG19.To see details of an item for auction, you may go to the _______________ section on auction page.20.Miss Andreasen publishes her research articles more often when ______rather than Nancy三、3.Listening Comprehension(10题)21.Section ADirections: In this section, you will hear 8 short conversations and 2 long conversations. At the end of each conversation, one or more questions will be asked about what was said. Both the conversation and the questions will be spoken only once. After each question there will be a pause. During the pause, you must read the four choices marked A, B, C and D, and decide which is the best answer.听力原文:W: I just made up a quart of orange juice this morning, and now I can't find it anywhere. Do you know what happened to it?M: Did you hear a crash earlier? That was it. I'm just as clumsy as ever.Q: What is the problem?(12)A.The woman doesn't like orange juice.B.The woman didn't come to see Everett.C.The man was in a car crash this morning.D.The man broke the container of juice.22.听力原文:Good morning everyone. My name is Craig Stone, and I'll be your guide for today's tour of Kyoto. First, I want to go over the itinerary of the tour, so everyone can enjoy the trip without being worried about being left behind along the way. Of course, no one has gotten lost so far.First of all, we'll be leaving at 9:15 outside the main train station exit. Be sure to board the bus by 9:00 sharp.We'll be visiting some of the most famous historical spots in Kyoto. Our first stop will be at the Golden Pavilion, a temple constructed in 1397. We'll be leaving there at 10:30. You'll have about forty-five minutes to stroll around the temple and its gardens.Our next destination will be Ryoanji Temple. That's always a difficult one to pronounce. This temple is famous for its beautiful rock garden. We'll departfrom the temple at 11:45.Next, we'll have lunch from 12:00 to 12:45.In the afternoon, we'll be making a brief stop at Heian Jingu Shrine, which was constructed in 1895 to commemorate the 1,100th anniversary of the founding of the city of Kyoto.After that, we'll head downtown and stop in Gion. Many people asked me about different traditional shopping areas, and this is a place we don't want to miss. You'll have about an hour to look around, and I'm sure you'll enjoy the atmosphere of the entire area—the shops, the homes, and the restaurants. We'll be leaving Glen at 2:30.Finally, we'll visit Nijojo Castle, which was the residence of the first Tokngawa Shogun. You'll have about an hour to tour the castle, and we'll meet at the bus at 4:00.(33)A.At 9:00.B.At 9:15.C.At 9:50.D.At 9:30.23.(32)A.It will rise an average of 1 foot.B.It will be worn down an average of 1 foot.C.It will be worn down to sea level.D.It will lose 730 million tons of solid matter.24.(29)A.Getting visitors to vote on the website.B.Getting more traffic.C.Turning its traffic into money.D.Contacting politicians and famous people.25.听力原文:M: I've got an invitation to a financial seminar. I don't want to go alone.W: Count me in. I need as much help as I can get managing my money.Q: What will the woman probably do?(17)A.Ask the man to help her manage her money.B.Help the man learn to manage his money.C.Pay for the seminar.D.Go to the seminar with the man.26.(25)A.Because they're quite impressive with a strong effect.B.Because they are not so frustrating as other expressions.C.Because they are practiced and repeated once and again.D.Because they are most people's favorite words.27.(13)A.The husband is not so observant.B.The wife is annoyed at her husband's absent-mindedness.C.The husband hasn't told the truth.D.The husband felt surprised about her wife's new hairstyle.28.(26)A.Someone who always talks about himself.B.The most violent type of coworkers.C.Someone who stabs your back.D.The most common annoying type of people.29.(21)A.He remembers that he does not have the video in his office.B.He realizes that the woman does not have a VCR.C.He is worried that he will not have the video back in time for his class.D.He realizes that he will not need the video from Friday to next week.30.Section CDirections: In this section, you will hear a passage three times. When the passage is read for the first time, you should listen carefully for its general idea. When the passage is read for the second time, you are required to fill in the blanks numbered from 36 to 43 with the exact words you have just heard. For blanks numbered from 44 to 46 you are required to fill in the missing information. For these blanks, you can either use the exact words you have just heard or write down theLarge companies need a way to reach the savings of the public at large. The same problem, on a smalle【B1】______ faces practically every companytrying to develop new products and create new jobs. There can be little【B2】______ of raising the sort of sums needed from friends and people we know, and while hanks may agree to provide short-term 【B3】______ , they are generally unwilling to provide money' on a 【B4】______ basis for long-termprojects. So companies turn to the public, inviting people to lend them money, or take a share in the business in【B5】______ for a share in future profits.They do this by【B6】______ stocks and shares in the business through tire Stock Exchange. By doing so, they can put into circulation the savings of 【B7】______ and institution, both at home and overseas. When the saver needs his money hack, he does not have to go to the company with whom he 【B8】______ placed it. Instead,【B9】______ .Many of the services needed both by industry and by each of us are provided by the government or by local authorities. Without hospitals, roads, electricity, telephones, railways, this country could not function.【B10】______ , requiring more money than is raised through taxes alone. The government, local authorities, and nationalized industries therefore【B11】______【B1】四、4.Reading Comprehension (Reading in Depth)(3题)31.Section BDirections: There are 2 passages in this section. Each passage is followed by some questions or unfinished statements. For each of them there are four choices marked A, B, C and D. You should decide on the best choice. Should doctors ever lie to benefit their patients – to speed recovery or to conceal the approach of death? In medicine as in law, government, and other lines of work, the requirements of honesty often seem dwarfed by greater needs: the need shelter from brutal news or to uphold a promise of secrecy; to expose corruption or to promote the public interest.What should doctors say, for example, to a 46-year-old man coming for a routine physical checkup just before going on vacation with his family who, though he feels in perfect health, is found to have a form. of cancer that will cause him to die within six months? Is it best to tell him the truth? If he asks, should the doctors deny that he is ill, or minimize the gravity of the prognosis? Should they at least conceal the truth until after the family vacation? Doctors confront such choices often and urgently. At times, they see important reasons to lie for the patient's own sake; in their eyes, such lies differ sharply from self-serving ones.Studies show that most doctors sincerely believe that the seriously ill do not want to know the truth about their condition, and that informing them risks destroying their hope, so that they may recover more slowly, or deteriorate faster, perhaps even commit suicide. As one physician wrote: "Ours is a profession which traditionally has been guided by a precept that transcends the virtue of uttering the truth for troth's sake, and that is 'as far as possible do no harm' ."Armed with such a precept, a number of doctors may slip into deceptive practices that they assume will "do no harm" and may well help their patients. They may prescribe innumerable placebos, sound more encouraging than the facts warrant, and distort grave news, especially to the incurably iii and the dying.But the illusory nature of the benefits such deception is meant to bestow is now coming to be documented. Studies show that, contrary to the belief of many physicians, an overwhelming majority of patients do want to be told the truth, even about grave illness, and feel betrayed when they learn that they have been misled. We are also learning that truthful information, humanely conveyed, helps patients cope with illness: helps them tolerate pain better, need less medication, and even recover faster after surgery.Not only do lies not provide the "help" hoped for by advocates of benevolent deception: they invade the autonomy of patients and make them unable to decide on informed choices concerning their health.The following are greater needs than honesty, except for ______.A.the need to shelter from brutal news of serious illnessB.the need to uphold a promise of secrecyC.the need to go on vacationD.the need to promote public interest32.Why is laughter generally believed to be the best medicine?A.Because it keeps people away from falling ill.B.Because it is an effective way to cure patients.C.Because it increases the content of oxygen in blood.D.Because it helps patients recover more quickly.33.It can be inferred from the last paragraph that ______.A.Dr. Chiu will be remembered for his special contributionB.the tracking of all documents might result in controversiesC.American Secret Service is heavily financing Dr. Chiu's researchD.printer manufacturers are reluctant to implement deliberate banding五、5.Error Correction(3题)34. 【S5】35.【S9】36.【S7】六、6.Error Correction(3题)37.【S6】38.【S4】39. 【S1】参考答案1.On Over-packaging Nowadays manufacturers pay more attention to the package or wrapping of products to attract consumers' eyes. These commodities with (1)splendid appearance do (2)appeal to a lot ofOn Over-packaging Nowadays manufacturers pay more attention to the package or wrapping of products to attract consumers' eyes. These commodities with (1)splendid appearance do (2)appeal to a lot of 解析:本文是一篇六级考试中常见的议论文,要求考生就“过度包装”这个话题展开论述。

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Creating efficient frontiers using excel. Suppose we have 3 risky assets whose net return has the mean vector and variance-covariance matrix given below:Asset Mean Variance-CovarianceMatrix Weights Ones MeanPortfolioReturnPortfolioVariancePortfolioSTDPortfolioConstraint1 0.06 1 0.3 0.3 0.07937210.176666122 2.42961 1.55872112 0.12 0.3 1 0.3 1.60316613 0.03 0.3 0.3 1 -0.682541To model the portfolio choice problem, I begin by highlighting the mean vector andgiving it a name. To do this, left-click on cell c9 and drag down until cell c11 and then release. Then go to the name-box, which is the white box in the upper right just abovethe "A" column. Click in the name-box, hit backspace, and then type a name for cells c9- c11. Then hit return. I used the name "mu" for the vector of mean returns as illustrated below:Then, I follow a similar approach with the variance-covariance matrix by clicking on cellF9 and then dragging across and down to cell H11. After the variance covariance matrixis highlighted, I go to the name box and give the variance covariance matrix the name "vcov" (Note: I don’t use quotes in the names).The efficient frontier consists of portfolios that only invest in the risky assets. Therefore,I introduce a vector that represents the portfolio weights in each asset. For now, I willassign the weights arbitrarily. Below, I will use excel to choose the weights optimally. For now, I have placed the weights in cells J9 through J11 and given them the name weights. Also, for convenience, I have created a column of ones and given it the name ones.To illustrate why the names are convenient, note that for given portfolio weights, the mean return on the risky asset portfolio is equal to the transpose of the weights vector multiplied by the mean vector. Using excel's matrix formula's, the transpose of the weights vector is given by "transpose(weights)", and to multiply "transpose(weights)" by the mean vector "mu" simply requires using the excel function mmult, which stands for matrix multiplication. The resulting mean return for the portfolio is given bymmult(transpose(weights),ones). In this expression, excel multiplies the transpose of weights by the vector of ones, producing the mean return on the portfolio.To program the mean return and store it in a cell, one uses the excel format for matrix formulas. For example, to store the mean return for the given weight vector in cell N9, click on cell N9, and then type "= mmult(transpose(weights),mu)" and then hit CTRL SHIFT ENTER. The quantity in the cell will be equal to the mean return and will change when the weights change or when the elements of the mean return vector change.To program the variance of the portfolio return, I use the fact that the variance of the portfolio return is the transpose of the weights vector multiplied by variance covariance matrix multiplied by the weights vector. To program this, first I multiply the transpose of of weights vector times the variance-covariance matrix. This produces the expression mmult(transpose(weights),vcov). Then, I have to multiply this expression by weights. Therefore, the final answer for portfolio variance ismmult(mmult(transpose(weights),vcov),weights). I have typed this expression into cell O9 using the same approach that I used for typing the mean return. Clicking on the cell will highlight the formula at the top of the excel spreadsheet. By changing the weights or changing the elements of the variance covariance matrix, the portfolio variance will change. The standard deviation of the portfolio return is just the square-root of the variance, and is given in cell P9. To compute portfolio std, I named portfolio variance portvar. The formula for portfolio std (standard deviation) is just portvar^.5. It is entered in cell P9 with an equal sign before the formula. Then you hit return to enter the formula. We are almost ready to start to use excel to compute the efficient frontier for this set of 3 assets. To compute the efficient frontier, we need to constrain the portfolio weights so that that they sum to 1. This is equivalent to imposing the condition thatmmult(transpose(ones),weights) sums to 1. We will impose this constraint when choosing portfolio weights. To do so, I have assigned the constraint to cell N17 by typing the formula mmult(transpose(ones),weights) into the cell. When I use the constrained maximization program, I will set the cell equal to 1, which will constrain the weights that I can choose. I have chosen to name the constraint "constraint".The last item to note before beginning to use solver is that it is useful to store the results of maximization problems in a convenient form for further analysis. Towards this end, in row 79 I have stored the weights vector along with mean portfolio return and portfolio std. To illustrate how this was done, I highlighted cells b79-d79 and then in the formula bar typed =transpose(weights) and hit CTRL SHIFT ENTER. This puts the transpose of the weights in a 1 by 3 row vector. Then, in cells e79, f79, and g79, I simply repeated the names portmean,, portvar, and portstd. This produces the same values at these cells that were computed earlier.stdvariancemeanweights0.079372 1.603166-0.68254 0.176666 2.42961 1.558721USING SOLVER TO FIND PORTFOLIO WEIGHTSThe textbook provides the answer to solving for the efficient frontier when there are 2 risky assets. When there are more than two risky assets, there are more complicated matrix formulas for solving for the efficient frontier. If there are complicated constraints, there may not be a formula for the efficient frontier. In this course, I will emphasize using a maximization program to solve for the efficient frontier. More specifically, we will use the excel program SOLVER to find the points on the efficient frontier.SOLVER is an excel add-in package. To find solver, click on tools on the menu bar. If you see solver in the menu, then it is installed and ready to be used. If you don't find solver, then click on tools, Add-Ins, then check Solver, and click OK. This should give you the capability to use solver.To illustrate how to use to find points on the efficient frontier, recall that the lowest point on the efficient frontier is the point that minimizes standard deviation of the portfolio return. To solve for the mean and std of return of the minimum std portfolio, and to solve for the weights in the portfolio, click on cell h79 (with the std on top) and then click on tools, solver. The result should give you a window that appears as follows:Click on set target cell, then, if it not already highlighted, click on h79 because we want to minimize portfolio std. After choosing the target cell then click on Min because we want to minimize the value of portfolio standard deviation. To do this, we change the weights in the portfolio, hence, write in weights where it says by changing cells. Then, where it says subject to the constraints click Add. This should bring up a window for each constraint. The window will appear as follows:For cell reference, fill in constraint (the name of the constraint). Click on the arrow and choose equal. Then in the box that says constraint, fill in the number 1. This constraint entered in this way guarantees that the weights sum to 1. Then click OK if this is the last constraint that has been added.After you have filled in all of the appropriate information in the solver box, it should appear as follows.Then, clicking Solve allows solver to choice the optimal portfolio weights to solve this problem.The weights, mean return, and standard deviation in line 79 will have changed because Iused solver. In particular, the new weights are those associated with the minimum std portfolio. The same is true of the mean, variance, and std of the portfolio.To save the new results, highlight them with your cursor, then right click and choosecopy. Then, highlight the part of a row with the same number of elements where youwant you save your results, and then right click and choose the special paste function.This will store your results for this portfolio. IMPORTANTLY, you need to use specialpaste so that your answers are stored, and not changed with each successive use of solver,or changein the portfolio weights. Put differently, special paste copies the numbers in the table, but does not move the cells when it moves the numbers. Therefore, later analysis won'taffect the stored values from special paste. Finally, to use special paste, you need tospecify special paste and then choose "values".Resultsstdvariancemeanweights0.3333330.3333330.3333330.070.5333330.730297 Note: this line contains points for 0.3095240.4523810.2380950.080.550.74162 the minimum variance portfolio.0.2857140.5714290.1428570.090.60.7745970.2619050.6904760.0476190.10.6833330.826640.2380950.809524-0.047620.110.80.8944270.2142860.928571-0.142860.120.950.9746790.02381 1.880952-0.904760.2 3.35 1.830301-0.45222 4.26185-2.809630.418.68333 4.322422The first item in results is the minimum std portfolio, it has a mean of 0.07 and std of0.730297. To compute another point on the efficient frontier I use solver to find theportfolio with the smallest variance for a portfolio that has a mean return of 0.08; then Iwill do the same for mean return of 0.09, and so on. After doing this, for many points, Ican graph the efficient frontier.To graph the next point on the efficient frontier, the requirement that it has a mean returnof 0.08 is a constraint. Therefore, I will need to add a second constraint when I invoke solver. Otherwise, the approach is similar to what I did for the first point. Therefore Iclick on cell h79, go to tools, solver, and then change the entries as needed (solverusually saves your previous choices so you only need to change them slightly when computing different points on the efficient frontier. To change the elements of aconstraint that solver has maintained as the default, click on the constraint in the solver window, then click on change, then make the change that is needed and then click on OK. Once you have entered all of the constraints, click on solve.HELPFUL HINTS:1. Remember to give names to cells that contain formulas. Then you can refer to the cell by its name instead of having to remember the cell location (such as h79). Note: excel does not allow you to rename a cell after you have given it a name.2. Use a split screen view when invoking solver. To split the screen, go to window, and then choose split from the menu. Doing so will cause the spread sheet to appear in 4 quadrants. By clicking and holding on the lines where the screen splits, you can change the split points. When I changed the split points, I dragged the vertical line to the extreme left so that my screen is only split vertically. Then, I dragged the horizontal line upwards so that the bottom screen area was larger than the top. Given these splitting points, in the upper screen I used the scroll bar to go to line 79. This is the line that contains the results for the weight vector, and in which cells f79, g79, and h79 contain the formulas for the mean, variance, and standard deviation of the portfolio with the weights given in cells b79 through d79. Therefore, I can simply click on these cells within solver when choosing which cells to maximize or minimize and when imposing the constraints on the mean return.When I use solver the points in line 79 will change. After each use of solver, I just copy the points in this line and then special paste them into lines 167 to 172. Because I use split screen, I don’t have to scroll around the screen when I use solver and then copy and paste from line 79.There are two final items. First, is graphing the efficient frontier. To do so and use excel's graphing routines, I copy the standard deviation and mean columns that begin with row 167 and put them next to each other below:0.7302970.070.741620.080.7745970.090.826640.10.8944270.110.9746790.121.8303010.24.3224220.4Then, I highlight both columns of data. Then I click on the chart wizard (shown as bar chart in toolbar menu). Then I choose xy graph, and then click on the graph subtype within the xy category. Then I click on next. In the next window, I indicate that the data is in columns. Then I click next. Then, I choose titles and gridlines as appropriate and click next. Then, I choose where the graphics will appear. In my case I chose them to appear as a new sheet. Then I click finish. The efficient frontier is graphed on the page labelled Chart1.The last task is finding the portfolio weights, and mean and return of the tangency portfolio. Suppose the risk free rate is 0.04 percent. Then, the to find the tangency portfolio, we simply find the portfolio that has the maximal sharpe ratio. I have named cell b227 rf which stands for riskfree rate. The sharpe ratio is the portfolio mean return minus the riskfree rate divided by the standard deviation of the portfolio return. I have programmed the sharpe ratio as (meanport - rf)/portstd in cell D227. Then I used solver to maximize the sharpe ratio subject to the constraints that the portfolio weights sum to 1. risk free sharpe rat0.04 0.087678The maximal sharpe ratio is 0.087678The portfolio weights and and mean variance and std of the portfolio with maximal sharpe ratio (also known as the tangency portfolio) is given below:stdvarianceweightsmean0.079372 1.603166 -0.68254 0.176666 2.42961 1.558721This concludes this handout. You should familiarize yourself with solver and with using excel to make portfolio computations using the basic approach that is used in this handout.。

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