奥美拉唑与雷尼替丁治疗慢性胃炎合并消化性溃疡的疗效对比

奥美拉唑与雷尼替丁治疗慢性胃炎合并消化性溃疡的疗效对比王慧梅
【期刊名称】《临床医学研究与实践》
【年(卷),期】2016(001)024
【摘要】目的：探究奥美拉唑与雷尼替丁治疗慢性胃炎合并消化性溃疡的治疗效果。

方法选取我院收治的2000例慢性胃炎合并消化性溃疡患者，按照服用药物的不同分为甲组1200例和乙组800例。

甲组患者给予奥美拉唑进行治疗，乙组患者给予雷尼替丁进行治疗，对比两组患者的治疗效果。

结果甲组患者的治疗总有效率为98.3%，高于乙组患者的92.6%，组间比较差异有统计学意义（ P<0.05）；治疗前，两组患者的 SF-36生活量表各项评分比较无明显差异（ P>0.05）。

治疗后1个月，甲组患者的生理功能、生理职能、总体健康评分均明显高于乙组
（ P<0.05），其余各项评分比较差异无统计学意义（ P>0.05）。

甲组不良反应发生率为2.50%，明显少于乙组的5.00%，组间比较差异具有统计学意义
（ P<0.05）。

结论在进行慢性胃炎合并消化性溃疡的治疗时，奥美拉唑与雷尼替丁均具有较好的治疗效果，但奥美拉唑的治疗效果更优，不良反应更少，安全性更高。

%Objective To explore the effect of omeprazole and ranitidine in the treatment of chronic gastritis and peptic ulcer. Methods Two thousand cases of chronic gastritis patients with peptic ulcer in our hospital were selected and divided into group A (1 200 cases) and group B (800 cases) according to the different drugs received. The patients in group A received omeprazole treatment, and patients in group B received ranitidine treatment. The treatment effect of the two groups was compared. Results
The total effective rate of group A was 98.3%, which was higher than 92.6% of group B, the difference between the two groups was statistically significant (P<0.05). Before treatment, there was no statistical significance on SF-36 scores between the two groups (P>0.05). After treating for one month, the scores of physical function, physiological function, general health in group A were higher than those in group B (P<0.05). There were no significant differences among the other scores (P>0.0 5). The incidence rate of adverse in group A was 2.5%, which was less than 5.00%in group B, the difference between the two groups was statistically significant (P<0.05). Conclusion The omeprazole and ranitidine both have good effect in treatment of chronic gastritis and peptic ulcer, but omeprazole has better efficacy, less adverse reactions and higher safety.
【总页数】2页(P78-79)
【作者】王慧梅
【作者单位】志丹县人民医院消化内科，陕西延安，717500
【正文语种】中文
【中图分类】R573
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