ER、PR、C-erbB-2、P53和Ki-67在乳腺癌组织中的表达及与其临床病理特征相关性

ER、PR、C-erbB-2、P53和Ki-67在乳腺癌组织中的表达
及与其临床病理特征相关性
于喜法;秦合军
【期刊名称】《实用癌症杂志》
【年(卷),期】2018(033)001
【摘要】Objective To investigate the expression of ER,PR,C-erbB-2,P53 and Ki-67 in breast cancer tissues and its correlation with clinicopathologic characteristics.Methods 106 patients diagnosed as breast cancer were selected,immunohisto-chemical method was used to detect expression of ER,PR,C-erbB-2,P53 and Ki-67 in breast cancer tissues,the correlation with clinicopathological characteristics were analyzed.Results The positive rates of ER,PR,C-erbB-2,P53 and Ki-67 in breast canc-er patients were
60.8%,57.55%,51.89%,44.34%and 73.58%,respectively.ER and PR were not correlated with tumor size and lymph node metastasis,but were related with staging and tissue typing of pathology;C-erbB-2,Ki-67 were correlated with lymph node metastasis and pathological staging,the difference was statistically significant(P<0.05);there had no significant correlation between P53 in patients with breast cancer and its clinicopathological features.ER and PR were negatively correlated with breast cancer tissue differentiation(γ=-0.121,γ=-0.316,P<0.01);C-erbB-2,P53 and Ki-67 and breast cancer tis-sue differentiation were positively
correlated(γ=0.207,γ=0.018,γ=0.284,P<0.01).Conc lusion ER,PR,C-erbB-
2,P53 and Ki-67 are effective diagnostic indicators of breast
bined detection can improve the diagnostic accuracy of breast cancer,and it is of great significance in evaluating the prognosis of patients with breast cancer.%目的探讨ER、PR、C-erbB-2、P53和Ki-67在乳腺癌组织中的表达及与其临床病理特征的相关性.方法选取确诊为乳腺癌患者106例作为研究对象,采用免疫组化法,检测乳腺癌组织中ER、PR、C-erbB-2、P53和Ki-67的表达情况,并分析其与临床病理特征的相关性.结果乳腺癌组织中ER、PR、C-erbB-2、P53和Ki-67的阳性表达率分别为60.8%、57.55%、51.89%、44.34%和73.58%.ER、PR与肿瘤大小和淋巴结转移无相关性,与组织学分型和病理分期有关;C-erbB-2、Ki-67与患者是否存在淋巴结转移和病理分期有关(P<0.05);P53表达水平与其临床病理特征无显著相关性.ER和PR与乳腺癌组织分化程度呈负相关(γ=-0.121,γ=-0.316,P<0.01);C-erbB-2、P53和Ki-67与乳腺癌组织分化程度呈正相关(γ=0.207,γ=0.018,γ=0.284,P<0.01).结论 ER、PR、C-erbB-2、P53和Ki-67是乳腺癌有效的诊断指标,联合检测可提高乳腺癌的诊断准确性,对乳腺癌患者预后的评估具有重要意义.
【总页数】4页(P39-42)
【作者】于喜法;秦合军
【作者单位】458000 河南省鹤煤集团公司总医院;458000 河南省鹤煤集团公司总医院
【正文语种】中文
【中图分类】R737.9
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