血清视黄醇结合蛋白、超敏C反应蛋白与糖尿病足的相关性分析

血清视黄醇结合蛋白、超敏C反应蛋白与糖尿病足的相关性
分析
陈若飞;陈伟;田进
【期刊名称】《检验医学与临床》
【年(卷),期】2017(014)012
【摘要】Objective To investigate the correlation between serum retinol binding protein(RBP) and high sensitive C reactive protein(hs-CRP)with diabetic foot.Methods One hundred and eighty-nine patients with type 2 diabetes mellitus(T2DM) in our hospital were selected and divided into the diabetic foot group(105 cases) and diabetes mellitus group(84 cases).Fifty healthy subjects were selected as the control group.The clinical indexes were compared among the three groups and the RBP and hs-CRP levels were also compared among different grades of diabetic foot.Results The levels of FBG,HbA1c,HOMA-IR,Cr,UA,RBP and hsCRP in the diabetic group were significantly higher than those in the control group(P＜0.05),which in patients with the diabetic foot were significantly higher than those in the control group and diabetes mellitus group(P＜0.05);in the patients with diabetic foot,the levels of FBG,HOMA-IR,Cr,UA,RBP and were significantly higher than those in the control group and diabetic group (P＜0.05).For the patients with diabetic foot,the levels of serum RBP,hs-CRP and HOMA-IR in the patients with Wagner grade Ⅱ-Ⅲ were significantly higher than those in the patients with Wagner grade Ⅰ (P＜0.05),the levels of serum
RBP,hs-CRP,HOMA-IR in the patients with Wagner grade Ⅳ-Ⅴ were significantly higher than those in the patients with Wagner grade Ⅰ,Ⅱ-Ⅲ (P＜0.05),but the FBG level had no statistical difference among various Wagner grades(P＞0.05);in the diabetes mellitus group,serum RBP and hs-CRP levels had significantly positive correlation with the levels of
FBG,HbA1c,HOMA-IR,Cr and UA (P＜0.05).Conclusion Serum RBP and hs-CRP levels in the patients with diabetic foot are significantly
increased,moreover which have significant correlation with the diabetic
foot grade and a certain value for evaluating the disease condition.%目的
探讨血清视黄醇结合蛋白(RBP)、超敏C反应蛋白(hs-CRP)与糖尿病足的相关性.
方法选择收治的2型糖尿病患者189例,将其分为糖尿病足组105例、糖尿病组
84例,并选择50例健康人作为对照组,比较3组受试者各临床指标,并比较不同分级糖尿病足患者RBP、hs-CRP水平.结果糖尿病组患者空腹血糖(FBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、肌酐(Cr)、尿酸(UA)、RBP、hs-CRP
水平明显高于对照组(P＜0.05),而糖尿病足组患者FBG、HbA1c、HOMA-IR、Cr、UA、RBP、hs-CRP水平明显高于对照组和糖尿病组(P＜0.05);对于糖尿病足患者,Wagner分级Ⅱ～Ⅲ级患者血清RBP、hs-CRP、HOMA-IR水平明显高于Ⅰ级(P＜0.05),而Ⅳ～Ⅴ级患者血清RBP、hs-CRP、HOMA-IR水平明显高于Ⅰ级、Ⅱ～Ⅲ级(P＜0.05),各级Wagner分级患者FBG水平差异无统计学意义(P＞0.05);糖尿痛组患者血清RBP、hs-CRP水平与患者FBG、HbA1c、HOMA-IR、Cr、UA呈正相关关系(P＜0.05).结论血清RBP、hs-CRP水平在糖尿病足患者中出现
明显升高,且与患者糖尿病足分级明显相关,对患者的病情评估具有一定的临床价值.【总页数】3页(P1683-1685)
【作者】陈若飞;陈伟;田进
【作者单位】重庆医科大学附属第一医院酉阳医院,重庆409899;重庆医科大学附属第一医院酉阳医院,重庆409899;重庆医科大学附属第一医院酉阳医院,重庆409899
【正文语种】中文
【相关文献】
1.2型糖尿病患者血清视黄醇结合蛋白4与血清超敏C反应蛋白、胰岛素抵抗的相关性研究 [J], 曾立;胡美华;熊淑惠
2.血清超敏C反应蛋白、铁蛋白、视黄醇结合蛋白4对妊娠期糖尿病的早期预测价值 [J], 符玲玲;江文科;陈昌明;刘振燕
3.视黄醇结合蛋白4、超敏C反应蛋白水平与糖尿病足的关系 [J], 王艳;罗娜;冯尚勇;佘敦敏;陈晖;朱妍;张真稳
4.血清超敏C反应蛋白和视黄醇结合蛋白检测在早期糖尿病肾病中的应用 [J], 齐力;丁旭;郭骏骐
5.晚期妊娠糖尿病血清总蛋白、视黄醇结合蛋白4水平与胎儿生长受限的相关性分析 [J], 符梅沙;吴小妹
因版权原因，仅展示原文概要，查看原文内容请购买。