NANOMETER-SCALE OPTICAL IMAGING BY THE MODULATION

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申请人:Luca Lanzano,Michelle Digman,Enrico Gratton
地址:Irvine CA US,Irvine CA US,San Clemente CA US
国籍:US,US,US
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专利内容由知识权出版社提供
专利名称:NANOMETER-SCALE OPTICAL IMAGING BY THE MODULATION TRACKING (MT) MET H OD
发明人:Luca Lanzano,Michelle Digman,Enrico Gr at t on
申请号:US134 35387 申请日:20120330 公开号:US20120250000A1 公开日:20121004 专利附图:
摘要:An optical imaging method based on a feedback principle in which the specific
scan pattern is adapted according to the shape of the sample. The feedback approach produces nanometer-resolved three dimensional images of very small and moving features in live cells and in a matter of seconds. Images of microvilli in live cultured opossum kidney cells expressing NaPi co-transporter proteins with different GFP constructs and images of cell protrusions in a collagen matrix are produced with a resolution of about 20 nm. Along cell protrusions in three dimensional cellular adhesions could be identified to the extracellular matrix.
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