线粒体DNA在固有免疫调节中的研究进展

线粒体DNA在固有免疫调节中的研究进展
胡琼源
【期刊名称】《医学研究生学报》
【年(卷),期】2017(030)004
【摘要】线粒体是细胞内氧化磷酸化以及合成ATP的最主要场所,以"动力工厂"著称.同时,线粒体还参与细胞的增殖、分化、信号传递及细胞凋亡等过程.近来研究表明,线粒体除了参与细胞能量代谢外,还发挥了其他的病理生理学功能.线粒体释放的损伤相关分子模式,尤其是mtDNA能够激活TLR-9,NLRP3炎性小体以及cGAS-STING信号通路诱导宿主固有免疫应答抵抗外来的病原微生物.虽然线粒体DNA 能够促进抗菌免疫防御和调节抗病毒信号传递,但是细胞损伤或凋亡所释放的mtDNA同时也能够诱导炎性疾病的产生.因此,mtDNA不但参与细胞代谢和能量合成,而且在固有免疫系统中发挥重要的意义.文章就mtDNA相关的信号通路在固有免疫中的作用进行综述.%Mitochondria is the main production site of oxidative phosphorylation and ATP, and it is famous as "energy factory of the cell".In addition, mitochondria also participates in the process of cellular proliferation, differentiation and apoptosis, and signal transduction.Recent studies have revealed that pathophysiological functions of mitochondria beyond traditional energetic metabolism in cells.Mitochondria-released DAMPs, particularly mtDNA, could activate innate immune responses by involving TLR9, NLRP3 and cGAS-STING signaling pathways.In addition to facilitating antibacterial immunity and regulating antiviral signaling, mounting evidences suggest that mtDNA
contributes to inflammatory diseases following cellular damage and apoptosis.In addition to its well-appreciated roles in cellular metabolism and ATP production, mtDNA appears to function as a key member in the innate immune system.Therefore, we highlight the emerging roles of mtDNA in innate immunity.
【总页数】4页(P432-435)
【作者】胡琼源
【作者单位】210009 南京,东南大学医学院
【正文语种】中文
【中图分类】R392
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