慢性应激大鼠血清肿瘤坏死因子-α、白细胞介素-6的变化及其对心率和血压的影响

慢性应激大鼠血清肿瘤坏死因子-α、白细胞介素-6的变化及
其对心率和血压的影响
徐艳秋;王洪巨
【期刊名称】《蚌埠医学院学报》
【年(卷),期】2011(36)2
【摘要】Objective: To observe the changes of serum tumor necrosis factor-α (TNF-α) and interleukin-6 ( IL-6 ), and their influence on the blood pressure and heart rates of rats by establishing models of chronic stress. Methods: Forty healthy male SD rats were randomly divided into two groups. Control group ( n = 10 ) were not given any incentives, and the experimental group ( n = 30 ) were established models of chronic stress with Katz method. Serum TNF-α and IL-6 levels of the rats were measured by enzyme-linked immunoassay, and the blood pressure and heart rates were recorded. Results:Compared with the control group, the open field activity of the rats with chronic stress decreased( P ＜ 0.01 ) ,serum IL-6 and TN F-α levels increased( P ＜ 0.05 ) ,the blood pressure was elevated and the heart rate speeded( P ＜ 0. 01 ). Conclusions: Stress may affect the emotional behavior, increase the serum IL-6 and TNF-α levels and influence the blood pressure and heart rates of the rats.%目的:观察慢性应激大鼠血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的变化,以及其对血压、心率的影响.方法:选用健康雄性SD大鼠40只,随机分2组.对照组10只不给予任何刺激,实验组30只参照Katz方法制作慢性应激模型.采用ELISA测定每只大鼠血清
TNF-α、IL-6的水平,并记录血压和心率.结果:与对照组比较,实验组大鼠旷场活动性降低(P<0.01),血清IL-6、TNF-α水平显著增高(P<0.05),血压增高、心率加快(P<0.01).结论:慢性应激影响大鼠的情感行为,可以升高大鼠血清TNF-α、IL-6水平,并影响血压、心率.
【总页数】3页(P127-129)
【作者】徐艳秋;王洪巨
【作者单位】安徽省宿州市立医院,心内科,234000;安徽省宿州市立医院,心内科,234000
【正文语种】中文
【中图分类】R363
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