脑室内出血致左侧穹窿脚损伤可呈现选择性语言记忆功能损害

脑室内出血致左侧穹窿脚损伤可呈现选择性语言记忆功能损害

穹窿作为Papez环路的一部分，在脑内侧颞叶与内侧间脑间传递情境记忆信息。因为穹窿形状态细长，且位置深，CT或MRI很难精确地将其与毗邻的神经结构区分开来。弥散张量纤维束成像可三维可视化穹窿，便于临床观察该解剖部位损伤情况。来自韩国岭南大学医学院的Sung Ho Jang博士等对1例选择性语言记忆障碍脑室出血患者的弥散张量纤维束成像检测结果进行报道。该病例为1例脑室内出血33岁男性。发病后1个月语言和视觉记忆能力差；发病后4个月，患者表现出明显视觉记忆改善的语言记忆障碍。DTT检测显示，发病后1个月，患者左侧穹窿脚不连续；发病后4个月，左侧穹窿脚向穹窿体方向退化，左穹窿柱向左内侧颞叶延伸。提示患者语言记忆障碍主要是左侧穹窿脚损伤所致。因此，临床医师应重点研究如何提高该类患者穹窿神经可塑性，改善其语言记忆功能。显示结果的文章发表在《中国神经再生研究（英文版）》杂志2014年7月第13期。

Article: "Selective verbal memory impairment due to left fornical crus injury in a patient with intraventricular hemorrhage" by Han Do Lee, Sung Ho Jang (Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namku, Daegu, Republic of Korea)

Lee HD, Jang SH. Selective verbal memory impairment due to left fornical crus injury in a patient with intraventricular hemorrhage. Neural Regen Res. 2014;9(13):1313-1315.

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Neural Regen Res

Selective verbal memory impairment due to left fornical crus injury after IVH

The fornix, a part of the Papez circuit, transfers information of episodic memory between the medial temporal lobe and the medial diencephalon. It is difficult to precisely assess the fornix due to its long, thin appearance and its location within the brain. In addition, discrimination of the whole fornix from adjacent neural structure using conventional brain CT or MRI is impossible. By contrast, diffusion tensor tractography (DTT) has enabled three-dimensional visualization of the fornix, and many studies have reported on fornix injury using DTT. Dr. Sung Ho Jang and co-workers from College of Medicine, Yeungnam University, Republic of Korea using DTT, report on a male patient, 33 years old, who showed selective verbal memory impairment due to left fornical crus injury following intraventricular hemorrhage (IVH).The patient showed impairment in both visual and verbal memory at 1 month after onset; in contrast, at 4 months after onset, the patient

showed selective verbal memory impairment with marked improvement of visual memory. One-month DTT for the fornix showed a discontinuation of the left fornical crus, and the discontinued left fornical crus was degenerated toward the fornical body as shown on 4-month DTT.By contrast, the left fornical column was extended to the left medial temporal lobe on both 1- and 4-month DTTs. These findings indicate that selective verbal memory impairment is mainly due to left fornical crus injury. Therefore, clinicians should focus on how to improve fornix neuroplasticity in these patients and thereby to improve their verbal memory function. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 13, 2014).

Article: "Selective verbal memory impairment due to left fornical crus injury in a patient with intraventricular hemorrhage" by Han Do Lee, Sung Ho Jang (Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Namku, Daegu, Republic of Korea)

Lee HD, Jang SH. Selective verbal memory impairment due to left fornical crus injury in a patient with intraventricular hemorrhage. Neural Regen Res. 2014;9(13):1313-1315.