Next Generation Molding Compound Materials for Flip Chip Matrix Array Molded Packages

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代谢工程概述-PPT

代谢工程概述-PPT

(1)基因工程技术的应用 (2)常规诱变技术的应用
2、 生物合成途径的代谢调控
(1)生物合成中间产物的定量生物测定 (2)共合成法在生物合成中的应用 (3)酶的诱导合成和分解代谢产物阻遏
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3、研究生物合成机制的常用方法
(1)刺激实验法 (2)同位素示踪法 (3)洗涤菌丝悬浮法 (4)无细胞抽提法 (5)遗传特性诱变法
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• 1. 生物能支撑观点 • 微生物细胞是工业发酵产物的生产者,微生物细胞的
生长和维持需要由其自身的能量转换机构或从其他形 式的能量转化形成的生物能来支撑。因此,工业发酵 具有生物学属性。
• 2. 代谢网络观点 • 由生化反应网络和跨输送步骤组成的代谢网络既没有
绝对的起点,也没有绝对的终点。代谢网络中任何一 种中间产物(或可借助生物学、化学方法与代谢网络联 网的任何一种化合物)都可能被开发成为工业发酵的目 的产物或原料。
简而言之,代谢工程是生物化学反应代谢网络有目的 的修饰。
代谢工程要解决的主要问题就是改变某些途径中的碳 架物质流量或改变碳架物质流在不同途径中的流量分布。 其目标就是修饰初级代谢,将碳架物质流导入目的产物 的载流途径以获得产物的最大转化率。
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代谢工程的主要特征就是利用DNA重组技术, 重建代谢网络,改变代谢流及分支代谢速度, 以改进代谢产物及蛋白类产品,由于外源 DNA的引入扩展了固有的代谢途径,获得了 新的化学物质。改变转化蛋白的过程,减少 不必要的废物。例如,谷氨酸发酵
“中心途径”和“离心途径”等连续的代谢途径的代谢,才能在胞内生成目的
产物,最后,目的产物跨过细胞质膜排出细胞回到培养介质中。
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1、胞外酶对原料的降解及营养物质进入细 胞的过程 2、经胞内降解代谢途径汇入中心代谢途径 3、中心代谢途径及其控制 4、合成代谢流及其控制 5、目的产物的跨膜及其控制

骨仿生材料的进展

骨仿生材料的进展

骨仿生材料的进展摘要:人口老龄化,疾病以及交通事故等造成大量的人体骨组织损伤和丢失。

现在人类致力于研究以生物大分子及其衍生物为模板进行复合材料的仿生合成,这些生物大分子主要有生物活性玻璃、胶原蛋白、透明质酸、磷酸丝氨酸等。

此外很多学者还在利用自组装法制备纳米羟基磷灰石/胶原(HA/COL)复合物,但是将这些材料用于人类时,需要考虑生物组织工程细胞相容性,所以人类采用人工合成材料生物活性玻璃陶瓷(BGC)与双相羟基磷灰石(HA/B-TCP)为支架材料,与聚-DL-乳酸(PDLLA)复合后再复合I型胶原及重组合人类骨形态发生蛋白,与兔骨膜成骨细胞复合培养以确定其相容性,同时还存在另一种问题,一些人造骨缺乏力学强度,尚不能在四肢负重部位修损。

关键词:骨仿生材料组织相容性负重组织工程骨一、前言目前,由于交通事故、疾病、人口老龄化造成的人体骨组织缺损、骨丢失、骨折、骨质疏松症已经引起广泛关注。

尽管自体骨具有优异的骨组织修复能力,但其来源有限,无法做到临床上大规模的应用。

在这种背景下,骨仿生材料的研制开始蓬勃发展。

但是骨组织修复材料的分子仿生设计合成目前还处于初期阶段,各种方法还不成熟,理想的有机基质模板的分子结构和组装方式及理想的矿化方式还有待研究。

很多学者采用有机分子调控无机相生长的策略,从生物分子调控水平上去理解骨的形成和矿化过程,并探究负重组织工程骨的新型支架的仿生学设计,同时组织工程细胞相容性的问题也在一直困扰着人们。

二、正文针对以上生物组织细胞相容性以及负重组织工程骨的问题,许多学者通过实验给出了有效的解决方法或发表了建设性的意见。

采用冷冻干燥和仿生矿化技术自制 4 种仿生复合骨组织工程三维支架材料分别是生物活性玻璃/胶原蛋白/透明质酸/磷酸丝氨酸、生物活性玻璃/胶原蛋白/磷酸丝氨酸、生物活性玻璃/胶原蛋白/透明质酸、生物活性玻璃/胶原蛋白。

将小鼠胚胎成骨细胞种植于自制 4 种支架及58S 生物玻璃支架上。

高分子材料工程专业英语第二版(曹同玉)课后单词电子教案

高分子材料工程专业英语第二版(曹同玉)课后单词电子教案

⾼分⼦材料⼯程专业英语第⼆版(曹同⽟)课后单词电⼦教案⾼分⼦材料⼯程专业英语第⼆版(曹同⽟)课后单词专业英语accordion ⼿风琴activation 活化(作⽤)addition polymer 加成聚合物,加聚物aggravate 加重,恶化agitation 搅拌agrochemical 农药,化肥Alfin catalyst 醇(碱⾦属)烯催化剂align 排列成⾏aliphatic 脂肪(族)的alkali metal 碱⾦属allyl 烯丙基aluminum alkyl 烷基铝amidation 酰胺化(作⽤)amino 氨基,氨基的amorphous ⽆定型的,⾮晶体的anionic 阴(负)离⼦的antioxidant 抗氧剂antistatic agent 抗静电剂aromatic 芳⾹(族)的arrangement (空间)排布,排列atactic ⽆规⽴构的attraction 引⼒,吸引backbone 主链,⾻⼲behavior 性能,⾏为biological ⽣物(学)的biomedical ⽣物医学的bond dissociation energy 键断裂能boundary 界限,范围brittle 脆的,易碎的butadiene 丁⼆烯butyllithium 丁基锂calendering 压延成型calendering 压延carboxyl 羧基category 种类,类型cation 正[阳]离⼦cationic 阳(正)离⼦的centrifuge 离⼼chain reaction 连锁反应chain termination 链终⽌char 炭characterize 表征成为…的特征chilled water 冷冻⽔chlorine 氯(⽓)coating 涂覆cocatalyst 助催化剂coil 线团coiling 线团状的colligative 依数性colloid 胶体commence 开始,着⼿common salt ⾷盐complex 络合物compliance 柔量condensation polymer 缩合聚合物,缩聚物conductive material 导电材料conformation 构象consistency 稠度,粘稠度contaminant 污物contour 外形,轮廓controlled release 控制释放controversy 争论,争议conversion 转化率conversion 转化copolymer 共聚物copolymerization 共聚(合)corrosion inhibitor 缓释剂countercurrent 逆流crosslinking 交联crystal 基体,结晶crystalline 晶体,晶态,结晶的,晶态的crystalline 结晶的crystallinity 结晶性,结晶度crystallite 微晶decomposition 分解deformation 变形degree of polymerization 聚合度dehydrogenate 使脱氢density 密度depolymerization 解聚deposit 堆积物,沉积depropagation 降解dewater 脱⽔diacid ⼆(元)酸diamine ⼆(元)胺dibasic ⼆元的dieforming ⼝模成型diffraction 衍射diffuse 扩散dimension 尺⼨dimensional stability 尺⼨稳定性dimer ⼆聚物(体)diol ⼆(元)醇diolefin ⼆烯烃disintegrate 分解,分散,分离dislocation 错位,位错dispersant 分散剂dissociate 离解dissolution 溶解dissolve 使…溶解distort 使…变形,扭曲double bond 双键dough (⽣)⾯团,揉好的⾯drug 药品,药物elastic modulus 弹性模量elastomer 弹性体eliminate 消除,打开,除去elongation 伸长率,延伸率entanglement 缠结,纠缠entropy 熵equilibrium 平衡esterification 酯化(作⽤)evacuate 撤出fiber 纤维flame retardant 阻燃剂flexible 柔软的flocculating agent 絮凝剂folded-chain lamella theory 折叠链⽚晶理论formulation 配⽅fractionation 分级fragment 碎屑,碎⽚fringed-micelle theory 缨状微束理论functional group 官能团functional polymer 功能聚合物functionalized polymer 功能聚合物gel 凝胶glass transition temperature 玻璃化温度glassy 玻璃(态)的glassy 玻璃态的glassy state 玻璃态globule ⼩球,液滴,颗粒growing chain ⽣长链,活性链gyration 旋转,回旋hardness 硬度heat transfer 热传递heterogeneous 不均匀的,⾮均匀的hydocy acid 羧基酸hydrogen 氢(⽓)hydrogen bonding 氢键hydrostatic 流体静⼒学hydroxyl 烃基hypothetical 假定的,理想的,有前提的ideal 理想的,概念的imagine 想象,推测improve 增进,改善impurity 杂质indispensable 不了或缺的infrared spectroscopy 红外光谱法ingredient 成分initiation (链)引发initiator 引发剂inorganic polymer ⽆机聚合物interaction 相互作⽤interchain 链间的interlink 把…相互连接起来连接intermittent 间歇式的intermolecular (作⽤于)分⼦间的intrinsic 固有的ion 离⼦ion exchange resin 离⼦交换树脂ionic 离⼦的ionic polymerization 离⼦型聚合irradiation 照射,辐射irregularity 不规则性,不均匀的isobutylene 异丁烯isocyanate 异氰酸酯isopropylate 异丙醇⾦属,异丙氧化⾦属isotactic 等规⽴构的isotropic 各项同性的kinetic chain length 动⼒学链长kinetics 动⼒学latent 潜在的light scattering 光散射line 衬⾥,贴⾯liquid crystal 液晶macromelecule ⼤分⼦,⾼分⼦均⽅末端距mechanical property ⼒学性能,机械性能mechanism 机理medium 介质中等的,中间的minimise 最⼩化minimum 最⼩值,最⼩的mo(u)lding 模型mobility 流动性mobilize 运动,流动model 模型modify 改性molecular weight 分⼦量molecular weight distribution 分⼦量分布molten 熔化的monofunctional 单官能度的monomer 单体morphology 形态(学)moulding 模塑成型neutral 中性的nonelastic ⾮弹性的nuclear magnetic resonance 核磁共振nuclear track detector 核径迹探测器number average molecular weight数均分⼦量occluded 夹杂(带)的olefinic 烯烃的optimum 最佳的,最佳值[点,状态] orient 定向,取向orientation 定向oxonium 氧鎓⽺packing 堆砌pattern 花纹,图样式样peculiarity 特性pendant group 侧基performance 性能,特征permeability 渗透性pharmaceutical 药品,药物,药物的,医药的phenyl sodium 苯基钠phenyllithium 苯基锂phosgene 光⽓,碳酰氯photosensitizer 光敏剂plastics 塑料platelet ⽚晶polyamide 聚酰胺polybutene 聚丁烯polycondensation 缩(合)聚(合)polydisperse 多分散的polydispersity 多分散性polyesterification 聚酯化(作⽤)polyethylene 聚⼄烯polyfunctional 多官能度的polymer 聚合物【体】,⾼聚物polymeric 聚合(物)的polypropylene 聚苯烯polystyrene 聚苯⼄烯polyvinyl alcohol 聚⼄烯醇polyvinylchloride 聚氯⼄烯porosity 多孔性,孔隙率positive 正的,阳(性)的powdery 粉状的processing 加⼯,成型radical ⾃由基radical polymerization ⾃由基聚合radius 半径random coil ⽆规线团random decomposition ⽆规降解reactent 反应物,试剂reactive 反应性的,活性的reactivity 反应性,活性reactivity ratio 竞聚率real 真是的release 解除,松开repeating unit 重复单元retract 收缩rubber 橡胶rubbery 橡胶态的rupture 断裂saturation 饱和scalp 筛⼦,筛分seal 密封secondary shaping operation ⼆次成型sedimentation 沉降(法)segment 链段segment 链段semicrystalline 半晶settle 沉淀,澄清shaping 成型side reaction 副作⽤simultaneously 同时,同步single bond 单键slastic parameter 弹性指数slurry 淤浆solar energy 太阳能solubility 溶解度sprinkle 喷洒squeeze 挤压srereoregularity ⽴构规整性【度】stability 稳定性stabilizer 稳定剂statistical 统计的step-growth polymerization 逐步聚合stereoregular 有规⽴构的,⽴构规整性的stoichiometric 当量的,化学计算量的strength 强度stretch 拉直,拉长stripping tower 脱单塔subdivide 细分区分substitution 取代,代替surfactant 表⾯活性剂swell 溶胀swollen 溶胀的synthesis 合成synthesize 合成synthetic 合成的tacky (表⾯)发粘的 ,粘连性tanker 油轮,槽车tensile strength 抗张强度terminate (链)终⽌tertiary 三元的,叔(特)的tetrahydrofuran 四氢呋喃texture 结构,组织thermoforming 热成型thermondynamically 热⼒学地thermoplastic 热塑性的thermoset 热固性的three-dimensionally ordered 三维有序的titanium tetrachloride 四氯化钛transfer (链)转移,(热)传递triethyloxonium-borofluoride 三⼄基硼氟酸⽺trimer 三聚物(体)triphenylenthyl potassium 三苯甲基钾ultracentrifugation 超速离⼼(分离)ultrasonic 超声波uncross-linked ⾮交联的uniaxial 单轴的unsaturated 不饱和的unzippering 开链urethane 氨基甲酸酯variation 变化,改变vinyl ⼄烯基(的)vinyl chloride 氯⼄烯vinyl ether ⼄烯基醚viscoelastic 黏弹性的viscoelastic state 黏弹态viscofluid state 黏流态viscosity 黏度viscosity average molecular weight黏均分⼦量viscous 粘稠的vulcanization 硫化weight average molecular weight重均分⼦量X-ray x射线 x光yield 产率Young's modulus 杨⽒模量。

电子科学与技术_专业英语_第三章大部分翻译..

电子科学与技术_专业英语_第三章大部分翻译..

电子科学与技术专业英语第三章大部分翻译(P139)3.1晶界生长与外延正如前面第一章所讨论的那样,在分立器件和集成电路中最重要的两种半导体是硅和砷化镓,在这一章我们叙述这两种半导体的常用的单晶生长技术,基本的工艺流程是从原料到抛光晶片,原料经过化学处理做成一个用来生长单晶的高纯多晶半导体。

单晶硅锭铸形,以定义材料的直径,这些晶片经过腐蚀和抛光来提供一个光滑的特定的且器件将做在上面的表面。

一种和单晶生长密切相关的技术包含一个单晶半导体层在一个单晶半导体衬底的生长,这叫外延,它是从希腊语epi 和taxis得来的,外延工艺提供了一种重要的控制掺杂形貌的技术,以至于器件和电流性能可以被优化。

例如,一个掺杂浓度相称低的半导体层可以在一个同型掺杂而浓度很高的衬底外延生长,通过这种方式和衬底相关联的体电阻将被充分地减少,许多新的器件结构,特别是微波和光学器件,可以通过外延工艺制得。

在这章的后面我们将考虑讨论一些重要外延生长技术。

(p140)3.2从熔体生长单晶从熔体生长单晶有两种基本方法,直拉法和布里奇曼法,用于半导体行业的充足百分比的硅单晶是通过直拉法制备的,实际上所有的用于集成电路制造的硅都是用这方法制备的。

大部份的砷化镓,在另一方面,是通过布里奇曼法生长的。

然而,直拉法在生长大直径的砷化镓方面变得越来越流行。

3.2.1原始材料硅的起始材料是一种相当纯的叫做石英的沙子形式。

它和各种形式的碳被置于炉中,当很多反应在炉中发生时,总的反应式是SI+SIO2=这种工艺生产出纯度98%的冶金及的硅。

下一步,硅被磨碎和氯化氢反应生成三氯氢硅(SIHCL3)SI + 2HCL三氯氢硅在温室下是液体,液体分馏除去不要的杂质,净化过后的SIHCL3用于与氢气反应。

制备电子级的硅(EGS):SIHCL3+这个反应在包括为硅的沉积提供晶体成核点的电阻加热硅棒的反应堆中发生,纯度为电子级别的硅,也就是一个高纯的多晶硅材料,是用于制备器件级质量的单晶硅的未加工材料。

生物材料的表面与界面材料表界面ppt课件

生物材料的表面与界面材料表界面ppt课件

3.3 生物相容性的研究意义
生物相容性是生物材料极其重要的性能,是区 别于其他材料的标志,是生物医用材料能否安 全使用的关键性能。
控制和改善生物材料的表面性质,是促进材料 表面与生物体间的有利相互作用、抑制不利相 互作用的关键途径。
如何提高材料的生物相容性

生物材料的表面工程是一种非常重要的方法!
国内从事生物材料表界面研究的课题组
生物材料的表面改性与功能化;
蛋白质、细胞与材料表面的相互作用;
苏州大学陈红教授课题组
➢Combining surface topography wi生 polymer chemistry: exploring new interfacial biological phenomena. Polym. Chem., 2013, DOI: 10.1039/C3PY00739A ➢Aptamer-Modified Micro/Nanostructured Surfaces: Efficient Capture of Ramos Cells in Serum Environment. ACS Appl. Mater. Interfaces, 2013, 5, 3816.
第一部分:生物材料表界面学科的诞生
1. 生物材料的概念(Biomaterials):
与生物体相接触的、或移入生物体内起某种取代、 修复活组织,增进或恢复其功能的特殊材料。
2. 生物材料的发展阶段
➢最初:一些临床应用的生物材料并不专门针对医用设计 (实现基本临床功能,也带来了不良的生物反应)
➢20世纪60-70年代:第一代生物材料(惰性生物材料) (物理性能适宜、对宿主反应较小;寿命延长5-25年)
其他领域的表面工 程技术和材料引入 生物材料领域或基 于体内物质的初步 模仿

三千多个 植物学名词中英文对照1

三千多个 植物学名词中英文对照1

盖高楼:全国科技名词审定委员会-植物学名词(1)盖高楼:全国科技名词审定委员会-植物学名词(2)01.001 植物学botany, plant science01.002 植物生物学plant biology01.003 植物个体生物学plant autobiology01.004 发育植物学developmental botany01.005 植物形态学plant morphology01.006 植物解剖学plant anatomy, phytotomy01.007 植物细胞学plant cytology01.008 植物细胞生物学plant cell biology01.009 植物细胞遗传学plant cytogenetics01.010 植物细胞形态学plant cell morphology01.011 植物细胞生理学plant cell physiology01.012 植物细胞社会学plant cell sociology01.013 植物细胞动力学plant cytodynamics01.014 植物染色体学plant chromosomology01.015 植物胚胎学plant embryology01.016 系统植物学systematic botany, plant systematics01.017 植物小分子系统学plant micromolecular systematics01.018 演化植物学evolutionary botany01.019 植物分类学plant taxonomy01.020 植物实验分类学plant experimental taxonomy01.021 植物化学分类学plant chemotaxonomy01.022 植物化学系统学plant chemosystematics 01.023 植物血清分类学plant serotaxonomy01.024 植物细胞分类学plant cellular taxonomy 01.025 植物数值分类学plant numerical taxonomy 01.026 植物分子分类学plant molecular taxonomy 01.027 植物病毒学plant virology01.028 藻类学phycology01.029 真菌学mycology01.030 地衣学lichenology01.031 苔藓植物学bryology01.032 蕨类植物学pteridology01.033 孢粉学palynology01.034 古植物学paleobotany01.035 植物生理学plant physiology01.036 植物化学phytochemistry01.037 植物生态学plant ecology, phytoecology01.038 植物地理学plant geography, phytogeography 01.039 植物气候学plant climatology01.040 植物病理学plant pathology, phytopathology 01.041 植物病原学plant aetiology01.042 植物毒理学plant toxicology01.043 植物历史学plant history01.044 民族植物学ethnobotany01.045 人文植物学humanistic botany 01.046 植物遗传学plant genetics01.047 植物发育遗传学plant phenogenetics 01.048 分子植物学molecular botany01.049 分类单位taxon 又称“分类群”。

第三代半导体的外延生长

第三代半导体的外延生长

第三代半导体材料是一种新型的半导体材料,具有优异的性能和广阔的应用前景。

与第一代硅基半导体和第二代化合物半导体相比,第三代半导体具有更高的电子迁移率、更大的能带宽度和更高的抗辐照性能,使其在光电器件、电子器件、能源转换和生物传感等领域具有重要的应用价值。

外延生长是一种制备半导体材料的方法,它通过在基底上沉积原子或分子,逐步扩大结构,最终形成单晶材料。

有几种常见的第三代半导体外延生长技术,包括金属有机化学气相外延(MOCVD)、分子束外延(MBE)和气相外延(VPE)等。

MOCVD是一种常用的外延生长技术,特点是可以快速生长大面积、高质量的晶体。

该方法通过将金属有机分子和气体反应,使得材料的元素以金属有机化合物的形式被传输到基底表面,并在高温下发生化学反应,最终生成所需的半导体材料。

MOCVD生长技术在第三代半导体的制备中得到了广泛应用,如GaN、InN和AlN 等。

MBE是一种高真空下的生长技术,是以分子束为载体进行外延生长的方法。

该方法通过在高真空环境下加热源材料,产生分子束,将分子束朝着基底表面瞄准,使其在基底上沉积并逐渐生长。

MBE具有生长速度较慢但控制精度高的优点,可以制备出高质量、低缺陷的半导体材料。

由于其在生长过程中能够精确控制材料组分,MBE在生长III-V族化合物半导体材料中得到了广泛应用,如GaAs、InAs和InP等。

VPE是一种通过热分解气体来生长材料的方法,其特点是可以快速高效地生长晶体。

该方法通过将金属有机化合物和气体送入反应室中,在高温下发生热反应,使得气体中的元素被沉积在基底表面上。

VPE生长技术可以生长出大尺寸的单晶材料,具有较高的生长速度和较低的生长温度。

然而,由于其生长过程中对材料的控制较难,容易引入缺陷并影响材料的性能。

除了以上提到的主要外延生长技术,还有其他一些方法可用于第三代半导体的生长,如分子束外延悬浮和液相外延等。

分子束外延悬浮是在气相中生长半导体材料的一种方法,通过在分子束外延的基础上添加悬浮液中的气溶胶粒子,可以调控其生长速度和晶体质量。

Molding compound introduction

Molding compound introduction

Properties of typical Epoxy
Type Items Cross-Linking Density Tg Flexural Strength at High Temperature Flexural Modulus at High Temperature Chemical resistance Electrical property Cost
OCH 3 H3 CO— Si OCH
3
O C 3 H6 —O—CH 2 —CH—CH 2
Attach to silica
Attach to resin
Manufacturing process of EMC
Epoxy resin fillers Catalyst
Flame retardant
Pigment
INTRODUCTION TO EPOXY MOLDING COMPOUND
Contents
What’s Epoxy Molding Compound (EMC)?
Manufacturing process of EMC How to process EMC? Package types and development trend KMC Series
1. Bi-phenyl Epoxy, BPH: Good adhesion & intension & electrical propert Bad thermal insistence & moisture insistence
很高的强度和粘接强度,较高的耐腐蚀性(chemical和电性 耐热性和韧性不高。 2. 酚醛环氧树脂: strength 优良的耐热性、强度、模量、电绝缘性、耐水性和 耐腐蚀性

湖大成功研发出人工骨新材料

湖大成功研发出人工骨新材料
用量 也在 1万套 以上 , 0 但是 国内市场份 额 的8%左右为 国外产品 占领 。 0
湖 北 大 学 的 这 项 研 究 成 果 一 旦 应 用 到 骨 修 复 产 品 制 造 上 , 不 仅 能 替 代 进 口 骨 修 复 产 品 , 还 能 降 低 国 内 骨 修 复 产 品 的 价 格。
( 龙 斌 )
等 。近 年来 , 因其 在生 理环境 中的潜在应 用价 值 ,氧化 还 原作用这 一刺 激手 段受 到越来 越 多 的关注 。 目前 ,氧化 还 原响应 性 的高分 子材料 主 要 为含 硫高 聚物 ,但其 对氧 化剂 和还 原剂 的 灵敏度 尚有待提高。 据报道 ,清 华大 学张希 教授和 许华平 副教 授课 题组 成功地 合成 了一 系列新 型 的主链 含硒 的两 亲性 嵌段 高聚物 。研 究表 明其 具有更 加灵 敏 还 原 响 应 性 。首 先 ,他 们 利 用 二 异 氰 酸 酯 与 两端 为想 翔基 的烷基 醚或 二硒醚 小 分子进 行逐 步聚 合得 到 了含 硒 的疏水 聚氨酯 链段 ;其 次 , 他们 通过进 一 步 的反应在含 硒疏 水聚 氨硒链 段 两 端 键 合 在 聚 乙二 醇 ,从 而 合 成 了聚 乙 二 醇 一一 b 含 硒 聚 氨 酯 .一 乙二 醇 两 亲 性 嵌 段 高 聚 物 。此 b聚 类 含 硒 两 亲 性 嵌 段 高 聚 物 在 水 溶 液 中 可 以 自组 装 形 成 胶 束 状 聚 集 体 ,此 聚 集 体 可 以 用 来 包 覆 药物 分子 ,在 非常温 和 的氧 化或 还 原条件 下实 现 聚 集 体 的 解 组 装 和 包 覆 药 物 分 子 的 可 控 释
放。 ( 聂尊誉 )
纳米碳 催化合成苯 乙烯 合作研 究获重大进展

医用镁合金微弧氧化

医用镁合金微弧氧化

第52卷第12期表面技术2023年12月SURFACE TECHNOLOGY·315·医用镁合金微弧氧化/有机复合涂层的研究现状及演进方向冀盛亚a,常成b,常帅兵c,倪艳荣a,李承斌a(河南工学院 a.电缆工程学院 b.车辆与交通工程学院c.电气工程与自动化学院,河南 新乡 453003)摘要:医用镁及镁合金过快的降解速率严重缩短了其有效服役时间,过高的析氢速率引发局部炎症,束缚了其临床应用前景。

微弧氧化(MAO)/有机复合涂层良好的抑蚀降析性能,在医用镁及镁合金表面改性领域展现出巨大的应用潜力。

首先,从有机材料(植酸(PA)、壳聚糖(CS)、硬脂酸(SA)、多巴胺(DA)、聚乳酸-乙醇酸共聚物(PLGA)、聚乳酸(PLA)、聚已内酯(PCL))自身的组织及性能特征入手,分析了单一有机涂层提高镁及镁合金耐蚀性的作用机理,并指出单一涂层自身的性能弱点(单一MAO涂层微孔和裂纹的不可避免,单一有机涂层与镁合金结合强度低,易于剥落)限制了对镁合金降解保护效能。

其次,从结合强度、耐蚀性、多功能性(生物安全性、生物相容性、诱导再生性、抑菌抗菌性、载药缓释性等)的角度,详细阐述了各MAO/有机复合涂层的结构特点、优势特征。

在此基础上,明确指出以MAO/PCL (MAO/CS)复合涂层为基底涂层,通过PCL(CS)涂层与其他涂层的交叉组合,是实现医用镁合金植入材料的生物活性及多功能性的最佳路径。

最后,对镁合金MAO/有机复合涂层的演进方向进行了科学展望。

关键词:镁合金;微弧氧化;有机材料;复合涂层;演进方向中图分类号:TG174.4 文献标识码:A 文章编号:1001-3660(2023)12-0315-20DOI:10.16490/ki.issn.1001-3660.2023.12.026Research Status and Evolution Direction of Micro-arc Oxidation/Organic Composite Coating on Medical Magnesium Alloy SurfaceJI Sheng-ya a, CHANG Cheng b, CHANG Shuai-bing c, NI Yan-rong a, LI Cheng-bin a(a. School of Cable Engineering, b. School of Vehicle and Traffic Engineering, c. School of Electrical Engineering andAutomation, Henan Institute of Technology, Henan Xinxiang 453003, China)ABSTRACT: Good biosafety, biocompatibility and valuable self-degradation properties endow medical magnesium and magnesium alloys with great potential to replace inert implant materials in the field of traditional clinical applications.The excessive degradation rate of magnesium alloy, however, leads to its premature loss of structural integrity and mechanical support, being unable to complete the effective service time necessary for tissue healing of the implant site. At the same time, it is also its excessive degradation rate that leads to the intensification of hydrogen evolution reaction of收稿日期:2023-02-01;修订日期:2023-05-14Received:2023-02-01;Revised:2023-05-14基金项目:河南省科技攻关项目(222102310337,222102240104,232102241029);博士科研资金(9001/KQ1846)Fund:Henan Province Science and Technology Research Project (222102310337, 222102240104, 232102241029); Doctoral Research Funding (9001/KQ1846)引文格式:冀盛亚, 常成, 常帅兵, 等. 医用镁合金微弧氧化/有机复合涂层的研究现状及演进方向[J]. 表面技术, 2023, 52(12): 315-334.JI Sheng-ya, CHANG Cheng, CHANG Shuai-bing, et al. Research Status and Evolution Direction of Micro-arc Oxidation/Organic Composite·316·表面技术 2023年12月magnesium alloy. Because it cannot be absorbed by the human body in a short time, the excessive H2 will easily gather around the implant or form a subcutaneous airbag, which will not only cause the inflammation of the implant site, but also hinder the adhesion and growth of cells in the implant, limiting its clinical application prospects. Surface modification technology can effectively delay the degradation rate of medical magnesium and magnesium alloys, and reduce the rate of hydrogen evolution.Firstly, starting from the structure and performance characteristics of organic materials (phytic acid (PA), chitosan (CS), stearic acid (SA), dopamine (DA), polylactic acid glycolic acid copolymer (PLGA), polylactic acid (PLA), and polycaprolactone (PCL)), the mechanism of improving the corrosion resistance of magnesium and magnesium alloys by a single organic coating was analyzed, and the performance weaknesses of a single coating were also pointed out: ①Micro arc oxidation (MAO) is an anodic oxidation process that generates a highly adhesive ceramic oxide coating on the surface of an alloy immersed in an electrolyte through high voltage (up to 300 V) spark discharge. The continuous high voltage discharge and the bubbles generated by the reaction bring about the inevitable occurrence of a large number of volcanic micropores and cracks in the coating. The diversity of discharge modes also gives rise to the unpredictable morphology of micropores and cracks. Therefore, the preparation of a single MAO coating on different alloy surfaces does not only require proper adjustment of MAO electrical parameters (current density, voltage, duty cycle, frequency, oxidation time) and the coupling effect of its electrolyte system to decrease (small) the pores and cracks on the MAO coating surface, but also increases the sealing process at the later stage. ② A single organic coating has a low bonding strength with magnesium alloy, being easy to flake off. These performance weaknesses limit the protection effect of a single coating on magnesium alloy degradation.Secondly, from the perspectives of bonding strength, corrosion resistance, and versatility (biosafety, biocompatibility, induced regeneration, antibacterial and antibacterial properties, drug loading and sustained-release properties, and so on), the structural characteristics and advantages of each MAO/organic composite coating were elaborated in detail. It has revealed that MAO/organic composite coating has an enormous application potentiality in the field of surface modification of medical magnesium and magnesium alloys, thanks to its good corrosion inhibition and degradation performance. On this basis, it is clearly pointed out that, in order to achieve the biological activity and versatility of medical magnesium alloy implant materials, the best way is to adopt the MAO/PCL (MAO/CS) composite coating as the base coating and make the cross combination of PCL (CS) coating and other coatings. Finally, the evolution direction of magnesium alloy MAO/organic composite coating is scientifically predicted.KEY WORDS: magnesium alloy; micro-arc oxidation; organic materials; composite coating; evolution direction作为人体所必须的营养元素,镁不但辅助600多种酶的合成(包括参与、维护DNA和RNA聚合酶的正确结构和活性),而且改善胰岛素稳定和糖类正常代谢、舒张血管、降低冠心病、高血压及糖尿病的患病风险[1]。

国际仿生工程研究动向与发展

国际仿生工程研究动向与发展
国际合作 前景研 究 。参 加 本次会 议 的专家 学者 分别
际仿生学界的著名学者。本次会议促进了国际工程 仿生学更为广泛的学术交流与合作。 仿生学通过研究生物体的结构、功能和工作原 理, 有意识地进行复制 、 改进和创新 , 并应用于工程 技术之中 , 明性能优越的仪器 、 发 装置和设备 , 创造 改良新技术。从仿生学的诞生、 发展 , 到现在短短几 十年时间内, 已取得了显著 的研究成果 。 仿生学的问
世开辟 了独 特 的技术 发展 道路 ,即向生物界索 取蓝 图 的道路 , 而 大大开 阔了人们 的眼界 , 从 显示 了极强
来 自 2 个 国家和地区的 7 家单位 ,与会人数共 3 l
的生命力。吉林大学工程仿生教育部重点实验室 自
※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※ ※
国际仿生工程研究动 向- q发展
任露泉 田喜梅 李建桥
( 吉林 大学工程仿 生教 育部 重点 实验 室, 长春 10 2 ) 3 0 2
2 1 国 际 仿 生 工 程 会 议 (ne aoa 00 Itr t nl n i
25名 , 中海 外 学 者 近 6 1 其 0人 , 括 多 名活 跃 在 国 包
理问题 。
保护环境、 实现可持续发展提供新的途径和手段 。 本次大会主席为吉林大学任露泉院士,副主席 为英国巴斯大学 Jl n i et ui VVn n 院士、英国诺丁 aF c 汉 大 学 Y y gY 教授 及 英 国曼 彻 斯特 大学 P t ui a n n ee r
很深入 , 尤其是在新一代的搜索引擎 Bn 上实现了 i g 很多先进的算法及用户感兴趣的应用。 国外 的研究普遍偏重 于以系统为中心的研究。 在大尺度数据库的建立和网络多媒体检索等方面有 很 大优势 。 主要是 由于 国外 的视 频共享 网站很 多 , 这 在商业上 , 对网络视频检索的研究有很大的推动力。

机械合金化

机械合金化
2
最初机械合金化仅着眼与氧化物与金属的混合,近年来,MA 也被用来实现非晶化。对于那些液态急冷或气相凝固有困难的 高熔点或蒸气压极其不同的金属元素的合金化十分有意义
MA是与液态急冷、化学沉积、溅社等方法不同,原因在于:MA 在引入大量的缺陷的同时,还伴随着强制固溶、强制扩散等过 程,使那些不易用上述方法制备的混合物合金化,非晶化。这 也是一个制备非晶的好方法
28
高硬度、耐磨WC-Co纳米复合材料
纳米结构的WC-Co已经用作保护涂层和切削工具 这是因为纳米结构的WC-Co在硬度、耐磨性和韧性等方面明显优于普通的 粗晶材料。其中,力学性能提高约一个量级,还可能进一步提高
高能球磨或者化学合成WC-Co纳米合金已经工业化 化学合成包括三个主要步骤 起始溶液的制备与混和;喷雾干燥形成化学性均匀的原粉末;再经流床热 化学转化成为纳米晶WC-Co粉末 喷雾干燥和流床转化已经用来批量生产金属碳化物粉末。WC-Co粉末可在 真空或氢气氛下液相烧结成块体材料。VC或Cr3C2等碳化物相的掺杂,可 以抑制烧结过程中的晶粒长大
4
二、机械合金化技术的起源与发展
•1966年INCO`s Paul D.Merca Research Lab, Benjamin发明 背景:ThO2弥散强化镍基高温合金
•60年代末期INCO的专利律师 Ewan C. MacQueen 命名为 “Mechanical Alloying” •70年代机械合金化制备铁基、铝基ODS合金 •80年代初发现机械合金化过程的非晶化现象 •80年代中后期,发现机械合金化可制备纳米晶材料 •90年代机械合金化制备纳米材料研究高峰
微颗粒化和晶化
颗粒细化, 非晶晶化, 部分结构发生回复
合金化
活性化与粉末焊合

模具的发展--中英文翻译

模具的发展--中英文翻译

Die history1 Die position in industrial productionMold is a high-volume products with the shape tool, is the main process of industrial production equipment.With mold components, with high efficiency, good quality, low cost, saving energy and raw materials and a series of advantages, with the mold workpieces possess high accuracy, high complexity, high consistency, high productivity and low consumption , other manufacturing methods can not match. Have already become an important means of industrial production and technological development. The basis of the modern industrial economy.The development of modern industrial and technological level depends largely on the level of industrial development die, so die industry to national economic and social development will play an increasing role. March 1989 the State Council promulgated "on the current industrial policy decision points" in the mold as the machinery industry transformation sequence of the first, production and capital construction of the second sequence (after the large-scale power generation equipment and the corresponding power transmission equipment), establish tooling industry in an important position in the national economy. Since 1997, they have to mold and its processing technology and equipment included in the "current national focus on encouraging the development of industries, products and technologies catalog" and "to encourage foreign investment industry directory." Approved by the State Council, from 1997 to 2000, more than 80 professional mold factory owned 70% VAT refund of preferential policies to support mold industry. All these have fully demonstrated the development of the State Council and state departments tooling industry attention and support. Mold around the world about the current annual output of 60 billion U.S. dollars, Japan, the United States and other industrialized countries die of industrial output value of more than machine tool industry, beginning in 1997, China's industrial output value has exceeded the mold machine tool industry output.2 China's mold industry and its development trendDie & Mould Industry StatusDue to historical reasons for the formation of closed, "big and complete" enterprise features, most enterprises in China are equipped with mold workshop, in factory matching status since the late 70s have a mold the concept of industrialization and specialization of production. Production efficiency is not high, poor economic returns. Mold production industry is small and scattered, cross-industry,capital-intensive, professional, commercial and technical management level are relatively low.According to incomplete statistics, there are now specialized in manufacturing mold, the product supporting mold factory workshop (factory) near 17 000, about 600 000 employees, annual output value reached 20 billion yuan mold. However, the existing capacity of the mold and die industry can only meet the demand of 60%, still can not meet the needs of national economic development. At present, the domestic needs of large, sophisticated, complex and long life of the mold also rely mainly on imports. According to customs statistics, in 1997 630 million U.S. dollars worth of imports mold, not including the import of mold together with the equipment; in 1997 only 78 million U.S. dollars export mold. At present the technological level of China Die & Mould Industry and manufacturing capacity, China's national economy in the weak links and bottlenecks constraining sustainable economic development. 2.1 Research on the Structure of industrial products moldIn accordance with the division of China Mould Industry Association, China mold is divided into 10 basic categories, which, stamping die and plastic molding two categories accounted for the main part. Calculated by output, present, China accounts for about 50% die stamping, plastic molding die about 20%, Wire Drawing Die (Tool) about 10% of the world's advanced industrial countries and regions, the proportion of plastic forming die die general of the total output value 40%.Most of our stamping die mold for the simple, single-process mode and meet the molds, precision die, precision multi-position progressive die is also one of the few, die less than 100 million times the average life of the mold reached 100 million times the maximum life of more than accuracy 3 ~ 5um, more than 50 progressive station, and the international life of the die 600 million times the highest average life of the die 50 million times compared to the mid 80s at the international advanced level. China's plastic molding mold design, production technology started relatively late, the overall level of low. Currently a single cavity, a simple mold cavity 70%, and still dominant. A sophisticated multi-cavity mold plastic injection mold, plastic injection mold has been able to multi-color preliminary design and manufacturing. Mould is about 80 million times the average life span is about, the main difference is the large deformation of mold components, excess burr side of a large, poor surface quality, erosion and corrosion serious mold cavity, the mold cavity exhaust poor and vulnerable such as, injection mold 5um accuracy has reached below the highest life expectancy has exceeded 20 million times, the number has more than 100 chamber cavity, reaching the mid 80s to early 90s the international advanced level.2.2 mold Present Status of TechnologyTechnical level of China's mold industry currently uneven, with wide disparities. Generally speaking, with the developed industrial countries, Hong Kong and Taiwan advanced level, there is a large gap.The use of CAD / CAM / CAE / CAPP and other technical design and manufacturemolds, both wide application, or technical level, there is a big gap between both. In the application of CAD technology design molds, only about 10% of the mold used in the design of CAD, aside from drawing board still has a long way to go; in the application of CAE design and analysis of mold calculation, it was just started, most of the game is still in trial stages and animation; in the application of CAM technology manufacturing molds, first, the lack of advanced manufacturing equipment, and second, the existing process equipment (including the last 10 years the introduction of advanced equipment) or computer standard (IBM PC and compatibles, HP workstations, etc.) different, or because of differences in bytes, processing speed differences, differences in resistance to electromagnetic interference, networking is low, only about 5% of the mold manufacturing equipment of recent work in this task; in the application process planning CAPP technology, basically a blank state, based on the need for a lot of standardization work; in the mold common technology, such as mold rapid prototyping technology, polishing, electroforming technologies, surface treatment technology aspects of CAD / CAM technology in China has just started. Computer-aided technology, software development, is still at low level, the accumulation of knowledge and experience required. Most of our mold factory, mold processing equipment shop old, long in the length of civilian service, accuracy, low efficiency, still use the ordinary forging, turning, milling, planing, drilling, grinding and processing equipment, mold, heat treatment is still in use salt bath, box-type furnace, operating with the experience of workers, poorly equipped, high energy consumption. Renewal of equipment is slow, technological innovation, technological progress is not much intensity. Although in recent years introduced many advanced mold processing equipment, but are too scattered, or not complete, only about 25% utilization, equipment, some of the advanced functions are not given full play.Lack of technology of high-quality mold design, manufacturing technology and skilled workers, especially the lack of knowledge and breadth, knowledge structure, high levels of compound talents. China's mold industry and technical personnel, only 8% of employees 12%, and the technical personnel and skilled workers and lower the overall skill level. Before 1980, practitioners of technical personnel and skilled workers, the aging of knowledge, knowledge structure can not meet the current needs; and staff employed after 80 years, expertise, experience lack of hands-on ability, not ease, do not want to learn technology. In recent years, the brain drain caused by personnel not only decrease the quantity and quality levels, and personnel structure of the emergence of new faults, lean, make mold design, manufacturing difficult to raise the technical level.2.3 mold industry supporting materials, standard parts of present condition Over the past 10 years, especially the "Eighth Five-Year", the State organization of the ministries have repeatedly Material Research Institute, universities and steel enterprises, research and development of special series of die steel, molds and othermold-specific carbide special tools, auxiliary materials, and some promotion. However, due to the quality is not stable enough, the lack of the necessary test conditions and test data, specifications and varieties less, large molds and special mold steel and specifications are required for the gap. In the steel supply, settlement amount and sporadic users of mass-produced steel supply and demand contradiction, yet to be effectively addressed. In addition, in recent years have foreign steel mold set up sales outlets in China, but poor channels, technical services support the weak and prices are high, foreign exchange settlement system and other factors, promote the use of much current.Mold supporting materials and special techniques in recent years despite the popularization and application, but failed to mature production technology, most still also in the exploratory stage tests, such as die coating technology, surface treatment technology mold, mold guide lubrication technology Die sensing technology and lubrication technology, mold to stress technology, mold and other anti-fatigue and anti-corrosion technology productivity has not yet fully formed, towards commercialization. Some key, important technologies also lack the protection of intellectual property.China's mold standard parts production, the formation of the early 80s only small-scale production, standardization and standard mold parts using the coverage of about 20%, from the market can be assigned to, is just about 30 varieties, and limited to small and medium size. Standard punch, hot runner components and other supplies just the beginning, mold and parts production and supply channels for poor, poor accuracy and quality.3 Die trend3.1 mold CAD / CAE / CAM being integrated, three-dimensional, intelligent and network direction(1) mold software features integratedDie software features of integrated software modules required relatively complete, while the function module using the same data model, in order to achieve Syndicated news management and sharing of information to support the mold design, manufacture, assembly, inspection, testing and production management of the entire process to achieve optimal benefits. Series such as the UK Delcam's software will include a surface / solid geometric modeling, engineering drawing complex geometry, advanced rendering industrial design, plastic mold design expert system, complex physical CAM, artistic design and sculpture automatic programming system, reverse engineering and complex systems physical line measurement systems. A higher degree of integration of the software includes: Pro / ENGINEER, UG and CATIA, etc.. Shanghai Jiaotong University, China with finite element analysis of metal plastic forming systems and Die CAD / CAM systems; Beijing Beihang HaierSoftware Ltd. CAXA Series software; Jilin Gold Grid Engineering Research Center of the stamping die mold CAD / CAE / CAM systems .(2) mold design, analysis and manufacture of three-dimensionalTwo-dimensional mold of traditional structural design can no longer meet modern technical requirements of production and integration. Mold design, analysis, manufacturing three-dimensional technology, paperless software required to mold a new generation of three-dimensional, intuitive sense to design the mold, using three-dimensional digital model can be easily used in the product structure of CAE analysis, tooling manufacturability evaluation and CNC machining, forming process simulation and information management and sharing. Such as Pro / ENGINEER, UG and CATIA software such as with parametric, feature-based, all relevant characteristics, so that mold concurrent engineering possible. In addition, Cimatran company Moldexpert, Delcam's Ps-mold and Hitachi Shipbuilding of Space-E/mold are professional injection mold 3D design software, interactive 3D cavity, core design, mold base design configuration and typical structure . Australian company Moldflow realistic three-dimensional flow simulation software MoldflowAdvisers been widely praised by users and applications. China Huazhong University of Science have developed similar software HSC3D4.5F and Zhengzhou University, Z-mold software. For manufacturing, knowledge-based intelligent software function is a measure of die important sign of advanced and practical one. Such as injection molding experts Cimatron's software can automatically generate parting direction based parting line and parting surface, generate products corresponding to the core and cavity, implementation of all relevant parts mold, and for automatically generated BOM Form NC drilling process, and can intelligently process parameter setting, calibration and other processing results.(3) mold software applications, networking trendWith the mold in the enterprise competition, cooperation, production and management, globalization, internationalization, and the rapid development of computer hardware and software technology, the Internet has made in the mold industry, virtual design, agile manufacturing technology both necessary and possible. The United States in its "21st Century Manufacturing Enterprise Strategy" that the auto industry by 2006 to achieve agile manufacturing / virtual engineering solutions to automotive development cycle shortened from 40 months to 4 months.3.2 mold testing, processing equipment to the precise, efficient, and multi-direction(1) mold testing equipment more sophisticated, efficientSophisticated, complex, large-scale mold development, testing equipment have become increasingly demanding. Precision Mould precision now reached 2 ~ 3μm, more domestic manufacturers have to use Italy, the United States, Japan and other countries in the high-precision coordinate measuring machine, and with digital scanning. Such as Dongfeng Motor Mould Factory not only has the capacity3250mm ×3250mm Italian coordinate measuring machine, also has a digital photography optical scanner, the first in the domestic use of digital photography, optical scanning as a means of spatial three-dimensional access to information, enabling th e establishment from the measurement of physical → model output of engineering drawings → → the whole process of mold making, reverse engineering a successful technology development and applications. This equipment include: second-generation British Renishaw high-speed scanners (CYCLON SERIES2) can be realized and contact laser probe complementary probe, laser scanner accuracy of 0.05mm, scanning probe contact accuracy of 0.02 mm. Another German company GOM ATOS portable scanners, Japan Roland's PIX-30, PIX-4 desktop scanner and the United Kingdom Taylor Hopson's TALYSCAN150 multi-sensor, respectively Three-dimensional scanner with high speed, low-cost and functional composite and so on.(2) CNC EDMJapan Sodick linear motor servo drive using the company's AQ325L, AQ550LLS-WEDM have driven fast response, transmission and high positioning accuracy, the advantages of small thermal deformation. Switzerland Chanmier company NCEDM with P-E3 adaptive control, PCE energy control and automatic programming expert systems. Others also used the powder mixed EDM machining technology, micro-finishing pulse power and fuzzy control (FC) technologies.(3) high-speed milling machine (HSM)Milling is an important means of cavity mold. The low-temperature high-speed milling with the workpiece, cutting force is small, smooth processing, processing quality, processing efficiency (for the general milling process 5 to 10 times) and can process hard materials (<60HRC) and many other advantages. Thus in the mold processing more and more attention. Ruishikelang company UCP710-type five-axis machining center, machine tool positioning accuracy up to 8μm, home-made closed-loop vector control spindle with a maximum speed 42000r/min. Italy RAMBAUDI's high-speed milling, the processing range of up to 2500mm × 5000mm × 1800mm, speed up 20500r/min, cutting feed speed of 20m/min. HSM generally used large, medium-sized mold, such as motor cover mold, die casting mold, large plastic surface machining, the surface precision up to 0.01mm.3.3 mold materials and surface treatment technology developed rapidly Industry to the level of mold, material application is the key. Due to improper selection and use of materials, causing premature die failure, which accounts for more than 45% failure die. In the mold material, commonly used cold work tool steel with CrWMn, Cr12, Cr12MoV and W6Mo5Cr4V2, flame hardened steel (such as Japan, AUX2, SX105V (7CrSiMnMoV), etc.; used a new type of hot work die steel American H13, Sweden QRO80M, QRO90SUPREME, etc.; used a pre-hardened plastic mold steel (such as the U.S. P20), age-hardening steel (such as the U.S. P21, Japan NAK55, etc.), heat treatment hardened steel (such as the United States, D2,Japan, PD613, PD555, Sweden wins the White 136, etc.), powder die steel (such as Japan KAD18 and KAS440), etc.; panel drawing die used HT300, QT60-2, Mo-Cr, Mo-V cast iron, large-scale mold with HT250. more regular use of Precision Die Hard Steel Results YG20 and other alloys and carbide. in the mold surface treatment, the main trends are: the infiltration of a single element to the multi-element penetration, complex permeability (such as TD method) development; by the general diffusion to the CVD, PVD, PCVD, ion penetration , the direction of ion implantation, etc.; can use the coating are: TiC, TiN, TiCN, TiAlN, CrN, Cr7C3, W2C, etc., while heat from the air treatment means to the development of vacuum heat treatment. In addition, the current strengthening of the laser, glow plasma Nitriding and electroplating (plating) enhanced anti-corrosion technologies are also more and more attention.3.4 mold industry new techniques, new ideas and new models have been gradually recognizedIn the forming process, the main function of composite stamping die, superplastic forming, plastic precision molding technology, plastic mold gas-assisted injection technology and hot runner technology, high-pressure injection molding technology. On the other hand, with the continuous development of advanced manufacturing technology and raise the level of mold industry as a whole, in the mold industry, there are some new design, production, management ideas and models. Concrete are: to adapt to the characteristics of mold-piece production flexible manufacturing technologies; to create the best management and effective teamwork, lean production; to enhance rapid response capabilities of Concurrent Engineering, Virtual Manufacturing and global agile manufacturing, manufacturing of new production networks philosophy; extensive use of standard parts common parts of the division of work mode of production; meet the environmental requirements of sustainable development and green design and manufacturing.SummaryThe 21st century, in the new situation of economic globalization, with capital, technology and labor market re-integration of equipment manufacturing in China after joining the WTO will become the world's equipment manufacturing base. In the modern manufacturing industry, no matter which industry, engineering equipment, are increasingly used to provide the products from the mold industry. In order to meet the user's high-precision mold manufacturing, short delivery time, the urgent demand low-cost, mold industry is extensive application of modern advanced manufacturing technology to speed up the mold industry, technological progress, to meet the basic sectors of the mold process equipment urgent needs.模具的发展1模具在工业生产中的地位模具是大批量生产同形产品的工具,是工业生产的主要工艺装备。

对器官生成的展望英语作文

对器官生成的展望英语作文

对器官生成的展望英语作文Advancements in Organ Generation: A Promising FutureThe field of organ generation has experienced remarkable advancements in recent years, offering hope for those in need of life-saving transplants. Through the integration of cutting-edge technologies and innovative research, scientists are making significant strides in developing viable solutions to address the growing demand for donor organs.One of the most promising avenues in organ generation is the use of stem cell technology. Researchers have successfully demonstrated the ability to derive various cell types, including those found in vital organs, from stem cells. This approach holds immense potential as it allows for the creation of personalized tissues and organs that are less likely to be rejected by the recipient's immune system. By harnessing the regenerative capabilities of stem cells, scientists can potentially cultivate replacement organs tailored to the individual patient's needs.Another exciting development in the field is the advancement of 3D bioprinting. This technology enables the precise fabrication ofcomplex tissue structures, including blood vessels, nerves, and even entire organs. By utilizing 3D printing techniques, researchers can create customized scaffolds that mimic the natural extracellular matrix, providing a suitable environment for cells to thrive and organize into functional tissues. The integration of 3D bioprinting with stem cell technology further enhances the prospects of generating viable organs for transplantation.Organ decellularization and recellularization is another innovative approach being explored by researchers. This process involves removing the cellular components from a donor organ, leaving behind the extracellular matrix. This scaffold is then seeded with the recipient's own cells, effectively creating a personalized organ that is less likely to be rejected by the body. This technique has shown promising results in animal studies and holds the potential to address the critical shortage of donor organs.In addition to the advancements in organ generation, researchers are also exploring alternative strategies to address the organ shortage. One such approach is the development of xenotransplantation, which involves the use of animal-derived organs for human transplantation. While this concept poses unique challenges, such as the risk of cross-species disease transmission, ongoing research is working to overcome these barriers and establish safe and effective xenotransplantation protocols.Furthermore, the integration of artificial intelligence and machine learning algorithms is revolutionizing the field of organ generation. These technologies are being leveraged to optimize the various stages of organ production, from cell culture and tissue engineering to the prediction of organ function and compatibility. By harnessing the power of AI, researchers can accelerate the development of personalized organ solutions and improve the overall efficiency of the organ generation process.As these innovative technologies continue to evolve, the future of organ generation holds immense promise. The ability to create customized, functional organs has the potential to transform the lives of millions suffering from organ failure. By addressing the critical shortage of donor organs, these advancements can alleviate the burden on healthcare systems, reduce waiting times for transplants, and ultimately save countless lives.However, the realization of this promising future is not without its challenges. Ethical considerations, regulatory hurdles, and the need for continued funding and collaboration among researchers and healthcare professionals must be carefully navigated. Nevertheless, the unwavering commitment and dedication of the scientific community, coupled with the growing public awareness and support, suggest that the future of organ generation is indeed bright.In conclusion, the advancements in organ generation offer a glimmer of hope for those in need of life-saving transplants. From the utilization of stem cell technology to the integration of 3D bioprinting and artificial intelligence, the field is poised to undergo transformative changes that can significantly improve the lives of countless individuals worldwide. As we continue to push the boundaries of scientific understanding and technological innovation, the future of organ generation holds the promise of a world where the shortage of donor organs is a thing of the past.。

鞋业中英文术语

鞋业中英文术语

computer stitching stain(comtamination) skive wrinkle seam stitching stapler sysmmetrical spray cement double(row)stitch stitching margin(edge) cement overflow msised stitching cosmetics(outlook) stitching marks manual work
ornamental(decorative)stitching
layer 裁向 perforation,punch 裁刀 loose grain 裁件 preparation team 裁板 cutting distortion 轮次 cutting operation qualification 电锈 die nick 网板 pairing,matching 切齐 pair label 烫压 size nicks 磨皮 attach reniforcement 削皮 blade 大小不一 hi-frequency welding/pressing 发料 washable 试刀 ink 自粘 thermo plastic(hot melt cement 摇臂式裁断机 overheated blade 油压 edge paint 虚线 edge binding 排刀 steam pressure 烫边 starch 修边 pre-buffing 油印台(跑马台) aluminum eyelet 晾皮架 double-sided die 开裁 attach 车前片饰片 stitch pull strap decoration line 印线 buffed edge double-stick tape asysmmetrical design gauge tension on thread hammer zigzag stitching sticky(tacky) paint single(row)stitch stitches per inch wrinkle broken needle repeated stitching upper thread parallel stitch thread end auto-stitiching folded edge cementing forepart stitching flat bed stitching machine 电脑针车 污染 削边 起皱 驳缝 订书机 对称 喷胶 双针 边距 胶水外溢 漏针 外观 记号线 手工车 饰线 探针车 去渍油 舌上商标 倒车(踏) 结舌

增材结构全流程技术体系 英语

增材结构全流程技术体系 英语

增材结构全流程技术体系英语Additive Manufacturing Process Technology SystemAdditive manufacturing, also known as 3D printing, has emerged as a revolutionary technology that has transformed the way we design, produce, and distribute products. This innovative approach to manufacturing has opened up new possibilities in various industries, from aerospace and automotive to healthcare and consumer goods. The additive manufacturing process technology system is a comprehensive framework that encompasses the entire lifecycle of creating and producing three-dimensional objects using digital data.At the core of the additive manufacturing process technology system is the concept of layer-by-layer fabrication. This method involves building an object by depositing successive layers of material, such as plastic, metal, or ceramic, based on a digital model. Unlike traditional subtractive manufacturing techniques, where material is removed to create the desired shape, additive manufacturing adds material to create the final product. This approach offers several advantages, including the ability to produce complex geometries, reduced material waste, and the potential for on-demand manufacturing.The additive manufacturing process technology system can be broadly divided into several key components, each playing a crucial role in the overall workflow. These components include:1. Design and Modeling: The process begins with the creation of a digital model, often using computer-aided design (CAD) software. This model represents the three-dimensional object that will be produced through the additive manufacturing process. The design phase also involves considerations such as part orientation, support structures, and material selection, which can significantly impact the final product quality and production efficiency.2. Data Preparation: Once the digital model is created, it must be prepared for the additive manufacturing process. This step involves converting the CAD data into a format that can be recognized by the 3D printer, such as the standard STL (stereolithography) file format. Additionally, the data may need to be processed to ensure proper slicing, support generation, and other necessary adjustments for the specific 3D printing technology being used.3. Additive Manufacturing: The actual production of the physical object takes place during the additive manufacturing stage. This involves selecting the appropriate 3D printing technology, such as fused deposition modeling (FDM), stereolithography (SLA), selectivelaser sintering (SLS), or direct metal laser sintering (DMLS), among others. Each technology has its own unique characteristics, materials, and processing parameters that must be carefully controlled to ensure the desired quality and performance of the final product.4. Post-Processing: After the 3D printing process, the printed object may require additional post-processing steps. These can include removing support structures, surface finishing, heat treatment, or other finishing techniques to improve the part's appearance, dimensional accuracy, and mechanical properties.5. Quality Assurance and Inspection: Ensuring the quality and consistency of the additive manufacturing process is crucial. This involves implementing robust quality control measures, such as in-process monitoring, dimensional inspections, and mechanical testing, to verify that the final product meets the required specifications and standards.6. Integration with Traditional Manufacturing: Additive manufacturing is not a standalone technology but rather a complementary approach to traditional manufacturing methods. The additive manufacturing process technology system often integrates with other production techniques, such as injection molding, casting, or machining, to create hybrid manufacturing solutions that leverage the strengths of both additive and subtractive processes.The success of the additive manufacturing process technology system relies on the seamless integration and optimization of these various components. Advancements in materials, printing technologies, software, and automation have continuously pushed the boundaries of what is possible with additive manufacturing, enabling the creation of increasingly complex and customized products.As the additive manufacturing industry continues to evolve, the process technology system will play a crucial role in driving innovation, improving efficiency, and expanding the applications of this transformative technology. By mastering the intricacies of the additive manufacturing process technology system, manufacturers and designers can unlock new opportunities, enhance product development, and stay ahead of the competition in the ever-evolving world of manufacturing.。

太赫兹波段超材料的制作、设计及应用

太赫兹波段超材料的制作、设计及应用

第6卷 第3期2013年6月  中国光学 Chinese Optics Vol.6 No.3June 2013 收稿日期:2013⁃02⁃17;修订日期:2013⁃04⁃15 基金项目:国家自然科学基金资助项目(No.10834015;No.61077082);陕西省科技新星资助项目(No.2012KJXX⁃27);陕西省光电技术与功能材料省部共建国家重点实验室培育基地基金资助项目(No.ZS12018)文章编号 1674⁃2915(2013)03⁃0283⁃14太赫兹波段超材料的制作、设计及应用潘学聪1,姚泽瀚2,徐新龙1,2∗,汪 力1(1.中国科学院物理研究所北京凝聚态物理国家实验室,北京100190;2.西北大学光子学与光子技术研究所光电技术与功能材料国家重点实验室培育基地,陕西西安710069)摘要:本文从制作方法、结构设计和材料选择几方面综述了超材料在太赫兹波段的电磁响应特性和潜在应用。

首先,介绍了获得不同维度、具有特异电磁响应以及结构可调超材料的各种微加工制作方法,进而分析和讨论了超材料的电磁响应特性。

文中指出,结构设计可以控制超材料的电磁响应特性,如各向异性、双各向异性、偏振调制、多频响应、宽带响应、不对称透射、旋光性和超吸收等。

超材料的电磁响应依赖于周围微环境的介电性质,因而可用于制作对环境敏感的传感器件。

此外,电光、磁光、相变、温度敏感等功能材料的引入可以获得光场、电场、磁场、温度等主动控制的太赫兹功能器件。

最后,简单介绍了超材料在太赫兹波段进一步发展所面临的机遇和挑战。

关 键 词:超材料;太赫兹技术;结构设计;调制;偏振中图分类号:O441;TB34 文献标识码:A doi:10.3788/CO.20130603.0283Fabrication ,design and application of THz metamaterialsPAN Xue⁃cong 1,YAO Ze⁃han 2,XU Xin⁃long 1,2∗,WANG Li 1(1.Beijing National Laboratory for Condensed Matter Physics ,Institute of Physics ,Chinese Academy of Sciences ,Beijing 100190,China ;2.State Key Laboratory Incubation Base of Photoelectric Technology and Functional Materials ,Institute of Photonics &Photon⁃Technology ,Northwest University ,Xi′an 710069,China )∗Corresponding author ,E⁃mail :xlxuphy@ Abstract :In this paper,the electromagnetic responses and potential applications of THz metamaterials are re⁃viewed through the focus on fabrication,unit structure design,and material selection,respectively.It de⁃scribes different kinds of fabrication technologies for obtaining metamaterials with special electromagnetic re⁃sponses such as magnetic resonance and reconfigurable tunability,which is helpful for further understanding of electromagnetic resonances in metamaterials.The paper analyzes the electromagnetic response characteristics in detail and points out that the unit structure design can be used to obtain desired electromagnetic characteris⁃tics,such as anisotropy,bianisotropy,polarization modulation,multiband response,broadband response,asymmetric transmission,optical activity,and perfect absorption,etc .The dependence of electromagnetic re⁃sponses upon surrounding dielectrics can be used not only to control resonant frequency by a proper substrateselection,but also for sensing applications.Furthermore,the introduction of functional materials with control⁃lable dielectric properties by external optical field,electrical field,magnetic field and temperature has the po⁃tential to achieve tunable metamaterials,which is highly desirable for THz functional devices.Finally,the op⁃portunities and challenges for further developments of THz metamaterials are briefly introduced.Key words:metamaterials;THz technology;structure design;modulation;polarization1 引 言 通过对自然材料的裁剪、加工和设计,从而实现对电子、光子以及其他一些元激发准粒子的人为调控,一直是光电科学研究的重点。

备课素材:人类后基因组研究进展2022-2023学年高一下学期生物人教版必修2

备课素材:人类后基因组研究进展2022-2023学年高一下学期生物人教版必修2

人类后基因组研究进展随着人类基因组计划(HGP)的顺利进行,生物医学研究已进入后基因组时代(Post genome era)[1]。

基因组学的研究从结构基因组学(S tructural genomics)过渡到功能基因组学(Functional genomics)。

结构基因组学代表基因组分析的早期阶段,这个阶段以建立生物体高分辨遗传、物理和转录图谱为主。

而以功能基因组学为代表的后基因组时代是利用结构基因组学提供的信息,系统的研究基因功能。

它以高通量、大规模实验方法及统计与计算机分析为特征[2]。

8~10万个基因的功能研究比HGP更为复杂和艰巨,必将成为下个世纪生命科学研究的主战场。

后基因组研究涉及的主要内容及方法有:1.生物信息学(Bioinformatics)随着人类基因组计划(HGP)在世界范围内的展开,产生了巨量的基因信息,分析这些信息是人类基因组研究必不可少的内容。

这也促成了生物信息学的发展。

生物信息学是用数理和信息科学的观点、理论和方法去研究生命现象,组织和分析呈指数增长的生物学数据的一门学科。

研究DNA和蛋白质,以计算机为主要工具,发展各种软件,把基因组DNA序列信息分析作为源头,在获得蛋白质编码区的信息之后进行蛋白质空间结构的模拟和预测,然后依据特定蛋白质功能进行必要的药物设计。

故此,生物信息学是由数据库、计算机网络和应用软件三大部分组成,对基因组信息学、蛋白质结构模拟以及药物设计的研究为主要目的的学科。

结构基因组学提供了巨大的DNA和蛋白质数据,功能基因组学的一个任务就是如何充分利用数据库去研究基因功能。

生物信息学在人类基因中的应用主要有:(1) 新基因的发现与鉴定使用基因组信息学的方法是发现新基因的重要手段,比如在啤酒酵母完整基因组(约1200万bp)所包含的5932个基因中,大约60%是通过信息分析得到的。

(2)非编码区信息结构分析虽然对约占人类基因组95%的非编码区的作用人们还不清楚,但从生物进化的观点看来,这部分序列必定具有重要的生物功能。

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Next Generation Molding Compound Materials for Flip Chip Matrix ArrayMolded PackagesLim Chong Sim a, Mun Leong Loke a, Kang Eu Ong a, Enrico Garcia a, Mohamed Syazwan Osman a, Leonel Arana b, Yoshihiro Tomita c, and Jiro Kubota ca Assembly & Test Technology Development – Malaysia, Kulim, Malaysiab Chandler Assembly Technology Development, Assembly & Test Technology Development, Chandler, Arizonac Pathfinding, Assembly & Test Technology Development, Tsukuba, Japanlim.chong.sim@Abstract—This manuscript describes the recent pathfinding and development activities on the molding compound for the flip chip matrix molded array (FCMX) platforms. The key focus of this manuscript is on the materials and packaging challenges associated with the high K molding compound and exposed second level interconnect molding. In addition the advantages and disadvantages of transfer and compression molding are discussed.1. IntroductionFCMX packages are the next generation of packaging technologies designed for the mobility and ultra mobility product segments. Over the last few years, the mobile computing technologies have evolved into increasingly complex systems, resulting in significant packaging challenges. The key challenges often associated with the FCMX platforms are strip warpage, which could potentially result in high yield loss for the downstream modules. High strip warpage may also leadto excessive package warpage, potentially violating the outgoing coplanarity specifications by the Joint Electron Device Engineering Council (JEDEC), which stipulates that a package with a ball grid array (BGA) pitch of < 0.5mm needs to meet an outgoing ball-coplanarity specification of under 100um.Various technology options have been explored previously to address the warpage concerns. This includes having the right media design to restrain the strips from warping during the assembly process flow. Although media acts as an effective restrainer, it is an expensive solution, which would typically require some level of compromise within the assembly process flowto enable integration of the media solution. Therefore from the manufacturability perspective, molding compound still remains as the most viable option for warpage controls.In this manuscript, discussions are focused on the molding compound issues and requirements for the different packaging technologies. Sections 3 and 4 are focused on flip chip matrix molded ball grid array generation 3 (FCMB3) high K molding compound development, while Section 5 focuses on the flip chip matrix molded ball grid array generation 4 (FCMB4) ultra long gellation compression mold formulation. In addition the different molding compound technologies that drive the formulation developments are described. 2. Background: Molding Compound Drivers 2.1. Generic Molding Compound RequirementsThe main function of molding compound is to protect the package from moisture, thermal and environmental exposure to ensure that it’s able to withstand its stipulated reliability requirements. In addition molding compound provides the package with the robustness for mechanical handling, packaging and assembly. Overall the molding compound requirements can be further summarized to the following key items:•Low moisture absorption – “Pop-corning”phenomenon occurs because of pressure buildingup from the out gassing of moisture within the packages during the level 3 preconditioning (L3P)stress resulting in interfacial or bulk fracture. In general, moisture absorption is lower for lower Glass Transition (T g ) resins such as the biphenyldue to the lower free volume within the cross-linked resins.•Adhesion to multiple interface – Good adhesion to multiple interfaces such as underfill, solder resistand silicon die is an important criteria to ensurethat there is no delamination between the interfacesduring assembly, which could result in crack propagation during temperature cycle stress.•Low cure shrinkage – One of the key factors affecting strip warpage is the shrinkage of the molding compound during curing. Cure shrinkageis defined by the differences between the total shrinkage with the thermal shrinkage.Given the contrasting differences in packaging architecture between FCMB3 and FCMB4 (to be discussed further in sections 3 and 5), a generic molding compound requirements is not sufficient tomeet the overall package performance. Therefore a significant amount of work was done to formulate different molding compound formulations to meet the competing needs of each packaging technology options.2.2. FCMX Packaging Roadmaps and TrendsFigure 1 shows the projected packaging trends for theFCMX platforms, which is based on the dimensional scaling of the transistor’s density and customer’s requirements. The key driver is the scaling of power delivery requirements due to an increase in transistors density in order to meet the customer’s request for an increase in functionality. This consequently results in an increase in junction temperature, which reduces the silicon performance. The other driver which is based on projected customer requirements is the dimensional scaling of the package Z height requirements, which results in a lower silicon thickness and a thinner substrate technology.Figure 1. Projected packaging trends for FCMX platforms.2.3. New or Complex Packaging TechnologyThe emergence of new and complex packaging technologies due to design constrains have resulted in a new set of molding compound requirements. Figure 2 illustrates the revisions in packaging architectures that the FCMB4 pathfinding platform has undertaken due to changes in the product specific roadmaps (PSR). In general, both the overmold and exposed second level interconnect packages are assembled using the 1269 silicon architecture on a high density interconnect (HDI) direct laser lamination (DLL3) strip technology, which is attained through the laminations of multiple build up materials with laser via [1]. The keyadvantages of the coreless DLL3 strip is the increase in signaling rates for high speed inputs outputs (HSIO) requirements and a reduction in the overall strip Z height. However this technology suffers from several drawbacks, including high warpage due to reduced thickness and absence of a core, which consequently results in yield loss at chip attach. The details on both the packaging technologies (1) Discrete over mold package and (2) Exposed second level interconnect molding will be discussed in details in the following sections.Figure 2. Revisions in FCMB4 Packaging Architecture2.4. Transfer vs. Compression MoldingTransfer molding has been Intel’s® legacy molding compound process for the Flip chip molded matrix array package 1 (FCMMAP 1), wire bonded and Flash platforms. However moving forward, the scalability for the transfer mold is at stake due to product requirements for a thinner mold clearance and lower temperature processing. Internal data collection on a package with 100um mold clearance indicated that the present transfer mold technology would be broken for molding compound with spiral flow <110cm as shown in Figure 3.Figure 3. Projected packaging trends for FCMX platforms.For the transfer molding process, molding compound pellets are placed into the plunger pots of the heated mold chase as shown in Figure 4. Once the mold compound is molten, the plunger transfers the molding compound through the runners into the cavity of the mold chase, and air in the chase cavities is vented out through strategically located venting holes. To ensure complete mold fill throughout the cavity of the mold chase, it’s important to define the right flow and melt viscosity properties. Nevertheless this is still a challenge for the high K molding compoundformulation because of the increase in melt viscosity with higher filler loading.Figure 4. Transfer molding bottom chase with plunger pots.The other known molding technique which was recently explored during the FCMB4 pathfinding is the compression mold. Compression mold shown in Figure 5 can be thought of as a runnerless mold system, because the molding compound is placed directly intothe cavity of the mold chase prior to clamping [2]. Thecompression molding technique is unique because of itsability to support both powder and liquid molding compound formulation. In addition compression mold has been demonstrated to be able to achieve thinner mold cap clearance. Compared to the transfer mold process, compression mold drives a reduction in through put time (TPT) with the omission of the molding compound transfer process shown in Figure 6.Figure 5. Compression molding bottom chase filled with mold.Figure 6. Potential TPT reduction with compression mold.From the materials perspective, compression molding drives a separate set of requirements compared to the transfer molding formulations. For instance lubricationwax is not required in the formulation because of the presence of mold film, which prevents the molding compound from sticking to the mold chase. In addition compression molding compound formulation typically requires a longer gelation time to enable it to flow and fill up the cavities within the mold chase.2.5. Critical Molding ParametersAmong the key critical factors for warpage reduction is design geometry, materials properties and processing conditions. From the materials perspective, keyproperties that influence the outcome of strip warpageare shrinkage factor, glass transition temperatures (T g ), coefficient of thermal expansion (CTE) and the modulus. Shrinkage factor is a dominant force for warpage control at room temperature, while the T g and CTE are crucial to controlling the dynamic warpage of the strips at reflow temperatures because of CTE mismatch.2.6. Test Vehicle ComparisonsVarious test vehicles (TV) were designed and taped out during the FCMB3 development phase and FCMB4 pathfinding phase as shown in Table 1. The key differences between both the platforms lie with the substrate technology used. FCMB3 Pinang TV is an LDI substrate with a core, while the FCMB4 Joslin 2 and Tonkin TV are DLL3 strips designed to meet the highdensity design rules. Due to the absence of cores, DLL3 strips are very flimsy, with high incoming warpage variations.Table 1. Test Vehicle comparison between FCMB3 and FCMB4.FCMB3 FCMB4 Attributes Pinang Joslin 2 Tonkin Die size 11 x 11mm 8 x 6mm 11 x 11mm Package size 13.8 x 13.8mm 13.8 x 13.8mm 13.8 x 13.8mm Substrate LDI DLL3 HDI DLL3 HDISilicon 1266 1266 1268 Ball pitch0.5mm 0.413mm 0.5mm3. High K Molding Compound forOvermolded Package80% Others MHSMold cure60%Clamp Injection3.1. Motivation for High K Mold Compound Technology Traditionally, for an over molded package (e.g FCMB3), the key challenge is to enable an effective heat dissipation path from the silicon to ensure that the overall package is meeting the TDP requirements. This is because any increment in temperature by a magnitude of 10-15o C above the T j limit of 110o C may result in a 2X difference in the lifespan of the device [3]. Technology roadmaps have projected that the future FCMX platform may be required to envelop products with power dissipations up to 35 Watts, thus emphasizing the need for an effective package and40%T i m e20% 0%Transfer moldCompression mold WB Compression mold FC Process material optimizationsystem level thermal solutions. Figure 7 shows that 90% of the heat generated by the silicon is dissipated through the board, and the remaining 10% dissipated to the surroundings via convection. This shows that molding compound could play an effective role in heat dissipation by virtue of providing a larger surface area for heat flow.Figure 7. Heat transfer path for a typical FCMX package.Thermal modeling in Table 2 has indicated that the conventional silica (SiO 2) filled molding compound formulation with a thermal conductivity value ofaround 0.8W/mK would not be able to meet the Thermal Design Power (TDP) targets for a 5 Watts power dissipation product. Instead a 3.2 W/m.K molding compound would be required.Table 2. T j max estimation based on 150um mold clearance.To increase its thermal conductivity, various thermally conductive ceramic fillers such as Alumina (Al 2O 3) and Silicon Carbide (SiC) were investigated. The additionof thermally conductive fillers adversely impacts themolding compound properties (higher CTE, higher modulus and shorter spiral flow). Therefore, the challenge lies in developing a thermally conductive molding compound technology, which is processable.3.2. High K Molding Compound FormulationsMarket survey on existing suppliers showed that the high K molding compound is a generally new formulation with low levels of market penetration within the industries. Therefore collaborations with several of the molding compound suppliers were formed to specially develop a formulation that will meet Intel’s thermal conductivity requirements of 5W/m.K. The key factors considered in the formulation were the choice of fillers and resin chemistries. For this a variety of ceramic fillers such as Al 2O 3, Silicon Carbide (SiC) and Aluminum Nitride (AlN) were all considered to enhance the thermal conductivity of the molding compound as shown in Table 3. Each of these fillers has their own sets of advantages and disadvantages. For instance although AlN fillers have the highest bulk thermal conductivity of ~270 W/m.K, it is still an unsuitable choice because of its hygroscopic nature which results in it being easily reversible into Al(OH)3 and ammonia (NH 3) under the presence of moisture [4].Table 3. Physical properties of thermal conductive fillers.Al 2O 3SiC AlN Density (g/cm 3) 4.00 3.22 3.26CTE (10-6o C -1) 7.60 4.51 4.40 Thermal conductivity (W/m.K) 30 220 270 Dielectric constant – 1MHz (k) 9.3 8.9 8.9 Young Modulus (GPa) 386 400 308As discussed in the previous sections, it’s important to strike a balance between the thermal conductivity targets with the flowability of the material. Figure 8 shows the correlation between melt viscosities and thermal conductivity. From the graphs it was established that the increment in filler ratio not only increases the thermal conductivity but also drives an increase in meltviscosities due to an increase in filler-matrix interactions. Some of the typical approaches used by molding compound suppliers to control the melt viscosities include selecting a lower viscosity resin to begin with.For this the biphenyl resin is somewhat a preferred option among the molding compound suppliers because of its low moisture uptake and good adhesion to multiple interfaces. In addition melt viscosities can be controlled by optimizing the filler distribution ratio and the hardener system used.1000Thermal conductivity Melt viscosity 6100Figure 8. Correlation between thermal conductivity and melt viscosity.Table 4 shows the list of all the molding compound materials which were evaluated during the FCMB4 pathfinding time frame. They include the X-43-3244-2 formulation, which serves as the baseline for data collection. The other formulations are the X-43-3248-1A and X-43-3248-1C, which were reiterations from the X-43-3248-1 formulation. The key differences between the materials lie in the filler systems used. To achieve a thermal conductivity of ~5W/m.K, the filler loading (wt%) of Al 2O 3 + SiO 2 fillers for the X-43-3248-1A formulation were increased from 75wt% to 77wt%,1030102030 40 Vol.% T h e r m a l c o n d u c t i v i t y (W /m .K )M e l t v i s c o s i t y a .s )(Pwhile for the X-43-3248-1C formulation, the SiO2 fillers were replaced with higher conductive SiC fillers. In addition silicone particles were added into the formulations to act to prevent excessive mold shrinkage during the curing process.Table 4. High K molding compound formulation comparison. Supplier(Materials)Material description Key propertiesShin-Etsu (X-43-3244-2) FCMB3 baselineMulti functional resin, 75Vol% Al2O3 + SiO2hybridT g – 183o CCTE 1/2 – 14/43ppmK – 3.2W/m.KSpiral flow – 88cmShin-Etsu (X-43-3248-1) Biphenyl resin, 75 Vol%Al2O3 + SiO2 hybridT g – 124o CCTE 1/2 - 13/53 ppmK - 3.2W/m.KSpiral flow – 127cmShin-Etsu(X-43-3248-1A) Biphenyl resin, 77 Vol%Al2O3 + SiO2 hybridT g – 120o CCTE 1/2 - 12/47ppmK - 4.3W/m.KSpiral flow – 78cmShin-Etsu(X-43-3248-1C) Biphenyl resin, 75 Vol%Al2O3 + SiC hybridT g – 122o CCTE 1/2 – 12/47ppmK = 4.7W/m.KSpiral flow – 70cmKyocera (G1250HT4) Low molecular weight,79% Al2O3 + SiO2 hybridT g – 130o CCTE 1/2 - 14/54ppmK = 4.6W/m.KSpiral flow – 105cmSumitomo (X80744) Biphenyl resin, 77 Vol%Al2O3 fillersT g – 130o CCTE 1/2 = 10/35ppmK = 5.0W/m.KSpiral flow – 90cm* All the data reported in Table 4 are suppliers’ data3.3. High K Molding Compound Assembly IssuesFigure 9 shows the overall process flow for the FCMB3 and FCMB4 over-molded package. The first step is to pre-bake the strips from underfill (CUF) module to drive off moisture, after which the out going strips is subjected to a plasma treatment to activate the surface in order to enhance the adhesion with the substrates. The following step is molding followed by a post mold cure to complete the cross-linking of the polymers.Figure 9. Assembly process flow for FCMB4/FCMB3 discrete overmold packages.One of the key challenges associated with the high K molding compound formulation is the significant increase in melt viscosity. As shown in Table 4, the molding compound viscosity increases significantly with an increase in filler loading. This may result in a range of issues due to the tight mold clearance between the die. In Table 5 mechanical models predicted that the mold cap requirements for a 5 Watts package needs to be < 100um thick if a 3.2W/m.K molding compound material were used.Table 5.T j max estimation for 10W power dissipation.Thermal conductivity (W/m.K)Moldclearance 0.8 3.2 5.0 10 20 250 um 179.4 116.1 108.5 101.8 98.4 150 um 145.6 107.7103.1 99.1 97.0 100 um 128.8 103.4 100.4 97.7 96.4 50 um 111.9 99.2 97.7 96.4 95.7 Besides incomplete fill, other key issues associated with the mold flowability are mold flow marks, shown in Figure 10. This phenomenon occurs only on molding compound formulations with very low spiral flow, (e.g X-43-3248-1A). Although flow mark may not have any known reliability implications, it may impact the 2 dimension unit identification (2DID) readability and may also fail the customers’ quality acceptance criteria. From the process perspective, lowering the molding temperature may help to improve mold flow marks. However the only complication is a potential reduction in adhesion.Figure 10. Mold flow marks on the strip after cure.3.4. Key Challenges: Excessive Strip Warpage Managing incoming strip warpage and subsequently keeping the strips flat throughout the assembly pipeline is the biggest assembly challenge for the FCMB4 platform. This is important; because high strip warpage has been known to interact with the downstream modules such as ball attach and saw singulation resulting in yield loss. Embedding glass cloths into the substrate build up layers helps to improve the overall strip warpage; but it’s still insufficient to drive the warpage below the limits acceptable by the downstream modules as shown in Figure 11. Mechanical modeling predicted that the glass cloth locations would have a certain degree of influence on the overall strip warpage. It was predicted that the Joslin TV with the bottom layer glass cloth would have the lowest strip warpage, followed by the center layer glass cloths. On the other hand, glass cloth layers also have its own set ofdisadvantages, including limitations on the package design rules and a higher cost target. In this section our discussions will center on the warpage response for the Joslin DLL3 1 layer glass cloth TV with different molding compound materials.Figure 11. Dynamic warpage for Joslin and Wilmot.Figure 12 compares the cluster level warpage ofShinEtsu X-43-3248-1C, Kyocera G1250GT-4 and the Sumitomo X80744 high K molding compound formulations. Warpage measurements on the incoming strips showed that the strips are warped in the ‘smiley’ directions. Once the post mold cured, the strip warpage increased in the ‘smiley’ direction for both the X-43-3248-1C and G1250GT4. This trend was nevertheless different for the Sumitomo X80744 molded strip, withthe warpage direction changing from ‘smiley’ to ‘crying’ after post mold cure process.Figure 12. Strip level warpage comparison at different process steps.As discussed, the strip warpage mechanism is typically influenced by the T g , CTE and modulus of the molding compound. One example is the increase in strip warpage along the smiley directions for X-43-3248-1C and G1250GT4 material. This is due to its low T g , which results in higher expansion of the mold due to the transformation from crystalline to a rubbery phase at temperatures above T g . In addition strip warpage is influenced by the mold compound shrinkage during the curing process. For example it is believed that the polymeric shrinkage of the X80744 mold during the curing process triggers a compressive force towards the substrate resulting in changes in warpage magnitude from “smiley’ to ‘crying’ as shown in Figure 13. To reduce the cure and thermal shrinkage, various reiterations have been previously investigated. This includes the addition of silicone micro phases which reacts with the resin system to expand the domains against the polymerization shrinkage.(4) Post (3) Post mold cure (2) Post mold(1) Post underfillFigure 13.Warpage mechanism at different process steps: (1)Substrate warp because of CTE mismatch with die (2) Infliction inwarpage direction after post mold cure because of mold shrinkage (3)Slight reduction in warpage because of relaxation in polymer chains with extended cure (4) Post singulation warpage.P o s t m o l d I n c o m i n g I n c o m i n g I n c o m i n g P o s t c u r e P o s t c u r e P o s t c u r e P o s t c u r eP o s t m o l d P o s t c u r e P o s t m o l d P o s t m o l d P o s t m o l d P o s t m o l d I n c o m i n g P o s t c u r e I n c o m i n g I n c o m i n g4. High K Mold Compound ReliabilityIssues4.1. IntroductionPassing the stipulated reliability stress test is an integral requirement for package certification. This requires the units to pass electrically (E-Test) at Level 3 preconditioning (L3P), and the subsequent readouts of unbiased highly accelerated stress test (HAST) 130o C/85%RH for 100 hours or temperature cycle profile B for up to 1000 cycles respectively. At every intermediate read out, the packages are screened with scanning acoustic microscope C-mode (CSAM) to check for any abnormalities at the interface.4.2. Reliability Fall OutsTable 6 lists the reliability data for the X-43-3244-2 molding compound at different reliability stress read outs. Two defects, namely mold-die delamination and mold cracking, were observed from the CSAM screening and will be discussed in further detail in the following subsections.Table 6. Reliability fall out for mold-die delam and mold crack . EOL L3P uHAST (50hr) TCB (500X) BHAST(2V)Mold-die 0/430 19/430 1/99 23/99 23/23Moldcrack0/160 0/160 0/80 34/80 NA4.3. Reliability Issues: Mold-Die DelaminationFigure 14 shows the CSAM and cross-section images on a unit with mold-die delamination after the L3P stress test. From the CSAM images, it was clear that mold-die delamination occurred only at the corners of the die. Cross sections revealed that mold-die delamination had a high potential risk of incurring electrical failures becauseof propagation along the mold to die path towards the mold-underfill interface.Figure 14. CSAM images of mold-die delamination (R) and cross section images of the delamination (L).The root cause for mold-die delamination is suspected to be a combination of poor adhesion and high peel stress at the corners of the die. This hypothesis was supported by the die thickness data in Figure 15, which concurred that the thicker dies (270um) have a significantly lower fall out than the thinner die (225um). The reason is packages with a thicker mold cap warps more due to the dominance of the molding compound, which exerts more peel stress at the corners of the silicon.Figure 15. X-43-3244-2 mold-die delamination fall out for twodifferent die thickness (225um and 270um).One of the solution paths considered to resolve mold-die delamination, was to increase the adhesion of the molding compound to the silicon interface. Therefore a new molding compound, X-43-3248-1, formulated with the biphenyl resin as its matrix, was brought in for further evaluation. Besides having good adhesion, thebiphenyl resin is also known to have low moisture uptake compared to the higher T g multifunctional resin. Figure 16 shows the results for the button shear test which was conducted after the post mold cure and L3P stress. The results showed that the X-43-3248-1 had adhesion strength in the magnitude of 30% higher compared to the X-43-3244-2 and the silica filled KMC2500VAT1. However the strength degrades marginally after the L3P stress test due to thermal degradation on the polymer matrix.Figure 16. Mold-die adhesion strength comparison between the X-43-3248-1 with the X-43-3244-2 and KMC2500VAT1.Table 7 shows the results for the X-43-3248-1 molding compound formulation at different reliability stress readouts. The result after L3P + uHAST 130oC/85%RH 100 hours is clean from any mold-die delamination. However when subjected to L3P + TCB500X stress, all of the 40 units loaded into the stress chamber failed for mold-die delamination based on CSAM inspections. This observation showed that the mold-die delamination defect observed on X-43-3248-1 molding compound is not moisture driven defect but is due to stress, aggravated by the low T g (124o C), which falls within therange of the TCB profile.Table 7. X-43-3248-1 fall out for mold-die delam.Mold compound EOL L3PuHAST(50hr)TCB (500X)X-43-3248-10/80 0/80 0/40 40/40Besides evaluating different molding compound formulations, equal focus was given to assessing the risk for mold-die delamination from the thermal perspective.Thermal modeling using the finite element method wascarried out to comprehend the gain in maximum junction temperature (T jmax ) if a delamination is present at the corners of the die. A sensitivity model for differentcumulative areas of delamination - 0.5%, 2%, 10%, 20%, 30% and 40% - was constructed to predict the minimum cumulative area of delamination that would be 270um/225um/490um 490umPost mold curePost L3P stress X-43-3244-2 X-43-3248-1KMC2500VAT1required before a significant rise in temperature will beobserved.The result for the sensitivity model shown in Figure 17, suggests that the rise in die corner temperature would be significant only if the total area of delamination for the four corners exceeds 10%, while the rise in die center temperature would be significant only if the total delamination area exceeds 40%. Therefore based on the modeling results, it was concluded that the thermal risk induced by the mold-die delamination defect is low, because none of the packages post reliability stress have a total delamination area exceeding 10%.Figure 17. Temperature rise at die center, die corner and mold top for different corner defects assumptions.4.4. Reliability Issues: Post TCB Mold-crackTable 8 quantifies the number of units with mold cracks at different reliability stress read out. The results showed that mold crack occurred only during the temperature cycle profile B (TCB) reliability stress test, which indicates that mold cracking is a thermo-mechanical stress induced defect. Visual observations in Figure 18 on all the CSAM images showed that the cracks initiate from the high stress edges of the 2DID and the Instruction set for execution (ISET) mark, indicating that flaw is pre-requisite for crack propagation to occur.Table 8. Reliability fall out for mold crack at different stress read out .EOL L3PuHAST (50hr)TCB(500X) TCB (1000X)Moldcrack 0/160 0/160 0/80 34/80 40/53Figure 18. Mold crack CSAM images at different stress read out.The key concern with mold cracking is the potential propagation of the crack length towards the silicon, which would result in units failing electrically due to die cracking shown in Figure 19. It was also observed that the units with mold cracks have resulted in mold-die delamination, which is a risk for thermal dissipation if the delamination exceeds 10% of the total area. To comprehend the root cause of mold cracking, a lab scale simulation GRC focusing on two possible root causes, molding compound formulation or laser mark depth was carried out as shown in Table 9. The motivation for including a non high K mold compound leg was to comprehend if the higher CTE of the high K molding compound could have induced more stress compared to a non high K mold formulation. This GRC was carried out by pre-heating the units on a hot plate at 300o C for 10 minutes before being soaked in liquid nitrogen for another 10 minutes to simulate the TCB stress test. This was repeated for a total of 4 cycles, with visual inspections being carried out for mold cracking after every cycle.Figure 19. Die crack from a post decap mold crack unit.Table 9. Lab scale GRC leg to decouple mold crack root cause.Molding compound Laser power (Watts) High K mold 1.43W 2.04W Non high K mold1.43W2.04WThe results in Table 9 showed that there was no mold crack observed for either the high and non high K molding compound after 4 cycles on the units marked with a 1.43 Watts laser power. On the other hand, units which were marked with a 2.04 Watts laser power showed mold cracking after 1 cycle of temperature simulation. This clearly showed that mold cracking is caused by the difference in mark depth induced by the different laser power. Hence it’s important to control the laser power and laser pulse of the 2DID to reduce the overall mark depth. The setback of doing so is the possible degradation in contrast for the 2DID readability.Therefore for risk mitigation, the other option, which was pursued without having to reduce the mark depth, was to move the 2DID mark away from the die shadow region to reduce the corner stress. This was based on the mechanical modeling quasi-static analysis, whichshowed that the higher stress region was within the die shadow because of the higher CTE mismatch between the mold-die compared to the mold-substrate interface shown in Figure 20.。

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