前列地尔联合保肝药物治疗肝损伤的临床疗效分析
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中外医疗 2019 NO.31 China &Foreign Medical Treatment
DOI院10.16662/ki.1674-0742.2019.31.090
前列地尔联合保肝药物治疗肝损伤的临床疗效分析
王艳梅 徐州市铜山区人民医院消化科袁江苏徐州 221006
[摘要] 目的 分析前列地尔联合保肝药物治疗肝损伤的临床疗效遥 方法 便利选取 2016 年 6 月要2019 年 1 月在该院
组的 9.68%袁但差异无统计学意义渊字2=0.220袁P跃0.05冤遥 结论 采用前列地尔联合保肝药物对肝损伤的临床疗效有显著
的提升袁能更有效地改善肝功能及降低炎症因子水平袁安全性高袁具有一定的推广使用价值遥
[关键词] 前列地尔曰保肝药物曰肝功能曰炎症因子
[中图分类号] R277
[文献标识码] A
[文章编号] 1674-074圆渊圆园员9冤11渊a冤原园090-03
Clinical Efficacy of Alprostadil Combined with Liver -protecting Drugs in the Treatment of Liver Injury
W A NG Y an-mei Department of Gastroenterology, Tongshan District People's Hospital, Xuzhou, Jiangsu Province, 221006 China [Abstract] Objective To analyze the clinical efficacy of alprostadil combined with liver-protecting drugs in the treatment of liver injury. Methods A total of 62 patients who underwent liver injury treatment in the hospital from June 2016 to January 2019 were Convenient selected and randomly divided into the control group (31 cases) and the observation group (31 cases). The liver drug (diammonium glycyrrhizinate) was treated, and the observation group was treated with alprostadil on the basis of the control group. Comparison of liver function indexes such as glutamyl transpeptidase (GGT), alanine aminotransferase (ALT) and total bilirubin (TBIL) and tumor necrosis factor (TNF-琢) and interleukin-8 (IL-8) before and after treatment. and other changes in inflammatory factors levels, while comparing the clinical efficacy and adverse reactions of the two groups after treatment. Results The total effective rate 96.77% in the observation group was higher than that in the control group 77.42%. The difference was statistically significant (字2=5.170, P约0.05). The levels of liver function indexes such as GGT, ALT and TBIL in the two groups after treatment. The levels of inflammatory factors such as TNF-琢 and IL -8 were lower than those before treatment, and the observation group was superior to the control group. The difference was statistically significant (P 约0.05). The adverse reaction rate of the observation group was 6.45% after treatment. The control group was 9.68%, but the difference was not statistically significant (字2=0.220, P跃0.05). Conclusion The clinical efficacy of alprostadil combined with liver-protecting drugs on liver injury has been significantly improved, it can improve liver function more effectively, and reduce the level of inflammatory factors. It has high safety and has certain promotion and use value. [Key words] Alprostadil; Liver-protecting drugs; Liver function; Inflammatory factors
情况袁同时比较治疗后两组的临床疗效及不良反应遥 结果 观察组临床总有效率 96.77%高于对照组 77.42%袁差异有
统计学意义渊字2=5.170袁P约0.05冤曰治疗后两组的 GGT尧ALT 及 TBIL 等肝功能指标水平和 TNF-琢尧IL-8 等炎症因子指标
水平均低于治疗前袁且观察组优于对照组袁差异有统计学意义渊P约0.05冤曰治疗后观察组的不良反应率 6.45%低于对照
接受肝损伤治疗的患者 62 例袁随机数字法分为对照组渊31 例冤和观察组渊31 例冤袁对照组采用保肝药物渊甘草酸二胺冤
பைடு நூலகம்
进行治疗袁而观察组在对照组的基础上采用前列地尔进行治疗遥 比较治疗前后两组谷氨酰转肽酶渊GGT冤尧谷丙转氨酶
渊ALT冤及总胆红素渊TBIL冤等肝功能指标水平和肿瘤坏死因子渊TNF-琢冤及白细胞介素-8渊IL-8冤等炎症因子水平的变化
DOI院10.16662/ki.1674-0742.2019.31.090
前列地尔联合保肝药物治疗肝损伤的临床疗效分析
王艳梅 徐州市铜山区人民医院消化科袁江苏徐州 221006
[摘要] 目的 分析前列地尔联合保肝药物治疗肝损伤的临床疗效遥 方法 便利选取 2016 年 6 月要2019 年 1 月在该院
组的 9.68%袁但差异无统计学意义渊字2=0.220袁P跃0.05冤遥 结论 采用前列地尔联合保肝药物对肝损伤的临床疗效有显著
的提升袁能更有效地改善肝功能及降低炎症因子水平袁安全性高袁具有一定的推广使用价值遥
[关键词] 前列地尔曰保肝药物曰肝功能曰炎症因子
[中图分类号] R277
[文献标识码] A
[文章编号] 1674-074圆渊圆园员9冤11渊a冤原园090-03
Clinical Efficacy of Alprostadil Combined with Liver -protecting Drugs in the Treatment of Liver Injury
W A NG Y an-mei Department of Gastroenterology, Tongshan District People's Hospital, Xuzhou, Jiangsu Province, 221006 China [Abstract] Objective To analyze the clinical efficacy of alprostadil combined with liver-protecting drugs in the treatment of liver injury. Methods A total of 62 patients who underwent liver injury treatment in the hospital from June 2016 to January 2019 were Convenient selected and randomly divided into the control group (31 cases) and the observation group (31 cases). The liver drug (diammonium glycyrrhizinate) was treated, and the observation group was treated with alprostadil on the basis of the control group. Comparison of liver function indexes such as glutamyl transpeptidase (GGT), alanine aminotransferase (ALT) and total bilirubin (TBIL) and tumor necrosis factor (TNF-琢) and interleukin-8 (IL-8) before and after treatment. and other changes in inflammatory factors levels, while comparing the clinical efficacy and adverse reactions of the two groups after treatment. Results The total effective rate 96.77% in the observation group was higher than that in the control group 77.42%. The difference was statistically significant (字2=5.170, P约0.05). The levels of liver function indexes such as GGT, ALT and TBIL in the two groups after treatment. The levels of inflammatory factors such as TNF-琢 and IL -8 were lower than those before treatment, and the observation group was superior to the control group. The difference was statistically significant (P 约0.05). The adverse reaction rate of the observation group was 6.45% after treatment. The control group was 9.68%, but the difference was not statistically significant (字2=0.220, P跃0.05). Conclusion The clinical efficacy of alprostadil combined with liver-protecting drugs on liver injury has been significantly improved, it can improve liver function more effectively, and reduce the level of inflammatory factors. It has high safety and has certain promotion and use value. [Key words] Alprostadil; Liver-protecting drugs; Liver function; Inflammatory factors
情况袁同时比较治疗后两组的临床疗效及不良反应遥 结果 观察组临床总有效率 96.77%高于对照组 77.42%袁差异有
统计学意义渊字2=5.170袁P约0.05冤曰治疗后两组的 GGT尧ALT 及 TBIL 等肝功能指标水平和 TNF-琢尧IL-8 等炎症因子指标
水平均低于治疗前袁且观察组优于对照组袁差异有统计学意义渊P约0.05冤曰治疗后观察组的不良反应率 6.45%低于对照
接受肝损伤治疗的患者 62 例袁随机数字法分为对照组渊31 例冤和观察组渊31 例冤袁对照组采用保肝药物渊甘草酸二胺冤
பைடு நூலகம்
进行治疗袁而观察组在对照组的基础上采用前列地尔进行治疗遥 比较治疗前后两组谷氨酰转肽酶渊GGT冤尧谷丙转氨酶
渊ALT冤及总胆红素渊TBIL冤等肝功能指标水平和肿瘤坏死因子渊TNF-琢冤及白细胞介素-8渊IL-8冤等炎症因子水平的变化