慢性前列腺炎及多灶型HGPIN患者再次穿刺时发展为前列腺癌风险的研究

慢性前列腺炎及多灶型HGPIN患者再次穿刺时发展为前列腺
癌风险的研究
李洁冰;张艳华;杨洪艳;张翠;李博;程文
【期刊名称】《实用肿瘤学杂志》
【年(卷),期】2017(31)3
【摘要】Objective The objective of this study was to investigate a risk of prostate cancer(PCa) at a repeat biopsy in patients with chronic prostate inflammation and widespread high grade prostatic intra epithelial neoplasia(wHGPIN).Methods From July 2006 to December 2014,172 cases of prostate biopsy were collected.All of them were diagnosed as HGPIN for the first biopsy,punctured by transrectal ultrasound for 12 points.After the first puncture for 6 months,patients were punctured for rebiopsy.Multi-focal wHGPIN was defined as a high -grade prostate intraepithelial neoplasia with 2 or more cores detection in a prostate biopsy.Isolated HGPIN was defined as a high-grade prostate intraepithelial neoplasia with only one core detection in a prostate biopsy.Results Seventy-two patients with HGPIN were isolated from primary HGPIN,102 patients with isolated HGPIN,17 patients with chronic prostatitis,70 with multifocal HGPIN and 54 with chronic prostatitis.Forth-eight of 172 patients initial diagnosis of HGPIN was diagnosed as PCa at rebiopsy.The detection rate of wHGPIN was 52.86％ (37/70)and isolated HGPIN for 10.88％ (11/102).They showed a statistically difference between two groups(P ＜0.001).The detection rate
of PCa in HGPIN patients with chronic prostatitis was higher than that in patients without chronic prostatitis(P =0.011).Chronic prostatitis and multifocal wHGPIN were a risk factor for prostate cancer independent by rebiopsy,confirmed by the logistic regression model.Conclusion Rebiopsy is a high risk factor of prostate adenocarcinoma for patients with chronic prostatitis and multifocal HGPIN initially diagnosed by the first
biopsy.Therefore,these patients are recommended under ultrasound induced by rectal prostate rebiopsy.%目的探讨伴有慢性前列腺炎及多灶型高级别前列腺上皮内瘤(Widespread high grade prostatic intraepithelial neoplasia,wHGPIN)患者再次活检,发展为前列腺癌风险的研究.方法 2006年7月-2014年12月收集前列腺再次穿刺活检者172例,均为初次活检病理诊断为HGPIN者,穿刺为经直肠超声引导下前列腺12点穿刺法.再次穿刺均是在初次穿刺6个月后进行的.多灶型HGPIN界定为在前列腺活检中有2针及以上检出高级别前列腺上皮内瘤,孤立型HGPIN界定为在前列腺活检中有1针检出高级别前列腺上皮内瘤.结果初次活检172例HGPIN患者,孤立型HGPIN 102例,伴有慢性前列腺炎患者17例;多灶型HGPIN 70例,伴有慢性前列腺炎患者54例;172例HGPIN 患者再次活检病理为前列腺腺癌者48例,多灶型HGPIN组检出率52.86％(37/70),孤立型HGPIN组检出率为10.78％(11/102),差异有统计学意义(P＜0.001);多灶型HGPIN伴有慢性前列腺炎组前列腺腺癌检出率高于不伴有慢性前列腺炎组,差异有统计学意义(P=0.011).经Logistic回归模型分析,慢性前列腺炎和多灶型HG-PIN 是再次活检为前列腺癌的独立风险因素.结论首次活检为慢性前列腺炎与多灶型HGPIN患者是再次活检为前列腺腺癌的高风险因素,建议超声引导下经直肠前列腺再次活检.
【总页数】5页(P217-221)
【作者】李洁冰;张艳华;杨洪艳;张翠;李博;程文
【作者单位】哈尔滨医科大学附属肿瘤医院超声科哈尔滨150081;哈尔滨医科大学附属肿瘤医院超声科哈尔滨150081;哈尔滨医科大学附属肿瘤医院超声科哈尔滨150081;哈尔滨医科大学附属肿瘤医院超声科哈尔滨150081;哈尔滨医科大学附属肿瘤医院超声科哈尔滨150081;哈尔滨医科大学附属肿瘤医院超声科哈尔滨150081
【正文语种】中文
【中图分类】R737.25
【相关文献】
1.高级别前列腺上皮内瘤患者血清 PSA 特征及再次穿刺时发展为前列腺癌的风险[J], 张明;于德新;万阳;闵捷;丁德茂;陈磊;张涛;邹慈
2.前列腺体积对于PSA4～10ng/mL患者前列腺癌诊断时穿刺方案的影响 [J], 赵坤;王鑫朋;刘利维;孙二琳
3.护士在静脉穿刺失败时的挫折反应与应对方式对再次穿刺成功率的影响 [J], 王帅华;高泽芬
4.再次穿刺活检在转移性去势抵抗前列腺癌中的应用研究 [J], 王帅;高凡;林涛
5.对小儿外科患者进行腹部手术时Seprafilm减低再次手术风险的功效 [J], Inoue M.;Uchida K.;Miki C.;Kusunoki M.;郭战宏
因版权原因，仅展示原文概要，查看原文内容请购买。