Pediatric_Eye_Evaluations 2010 美国 眼科 PPP 指南
美国眼科学会临床实践指南系列丛书:糖尿病视网膜病变
DiabeticRetinopathyPrepared by the AmericanAcademy of OphthalmologyRetina PanelRetina Panel MembersEmily Y. Chew, MD, Chair, Macula Society and Retina Society Representative William E. Benson, MDH. Culver Boldt, MDTom S. Chang, MDLouis A. Lobes, Jr., MDJoan W. Miller, MDTimothy G. Murray, MD, American Societyof Retina Specialists Representative Marco A. Zarbin, MD, PhDLeslie Hyman, PhD, Methodologist Preferred Practice Patterns Committee MembersJoseph Caprioli, MD, ChairJ. Bronwyn Bateman, MDEmily Y. Chew, MDDouglas E. Gaasterland, MDSid Mandelbaum, MDSamuel Masket, MDAlice Y. Matoba, MDDonald S. Fong, MD, MPHAcademy StaffNancy Collins, RN, MPHFlora C. Lum, MDMario ReynosoMedical Editor: Jeff Van BuerenDesign: Socorro Soberano Reviewed by: CouncilApproved by: Board of TrusteesSeptember2003 Copyright © 2003American Academy of Ophthalmology ®All rights reserved As a service to its members and the public, the American Academy of Ophthalmology has developed a series of guidelines called Preferred Practice Patterns™ that identify characteristics and components of quality eye care.The Preferred Practice Patterns are based on the best available scientific data as interpreted by panels of knowledgeable health professionals. In some instances, such as when results of carefully conducted clinical trials are available, the data are particularly persuasive and provide clear guidance. In other instances, the panels have to rely on their collective judgment and evaluation of available evidence.Preferred Practice Patterns provide guidance for the pattern of practice, not for the care of a particular individual. While they should generally meet the needs of most patients, they cannot possibly best meet the needs of all patients. Adherence to these Preferred Practice Patterns will not ensure a successful outcome in every situation. These practice patterns should not be deemed inclusive of all proper methods of care or exclusive of other methods of care reasonably directed at obtaining the best results. It may be necessary to approach different patients’ needs in different ways. The physician must make the ultimate judgment about the propriety of the care of a particular patient in light of all of the circumstances presented by that patient. The American Academy of Ophthalmology is available to assist members in resolving ethical dilemmas that arise in the course of ophthalmic practice.Preferred Practice Patterns are not medical standards to be adhered to in all individual situations. The Academy specifically disclaims any and all liability for injury or other damages of any kind, from negligence or otherwise, for any and all claims that may arise out of the use of any recommendations or other information contained herein.Innovation in medicine is essential to assure the future health of the American public, and the Academy encourages the development of new diagnostic and therapeutic methods that will improve eye care. It is essential to recognize that true medical excellence is achieved only when the patients’ needs are the foremost consideration.All Preferred Practice Patterns are reviewed by their parent panel annually or earlier if developments warrant and updated accordingly. To ensure that all Preferred Practice Patterns are current, each is valid for 5 years from the “approved by” date unless superseded by a revision.Financial Disclosures:No proprietary interests were disclosed by members of the Preferred Practice Patterns Retina Panel for the past 3 years up to and including June 2003 for product, investment, or consulting services regarding the equipment, process, or products presented or competing equipment, process, or products presented.TABLE OF CONTENTSINTRODUCTION (2)ORIENTATION (3)Entity (3)Disease Definition (3)Patient Population (3)Activity (3)Purpose (3)Goals (3)BACKGROUND (4)Epidemiology (4)Risk Factors (4)Natural History (4)PREVENTION AND EARLY DETECTION (6)CARE PROCESS (8)Patient Outcome Criteria (8)Diagnosis (8)History (9)Examination (9)Examination Schedule (9)Type 1 (Diabetes Onset Usually between Ages 0 and 29 Years) (9)Type 2 (Diabetes Onset Usually at Age 30 Years or Older) (9)Diabetes Associated with Pregnancy (10)Ancillary Tests (10)Color Fundus Photography (10)Fluorescein Angiography (10)Ultrasonography (Echography) (11)Optical Coherence Tomography (11)Treatment (11)Normal or Minimal NPDR (12)Mild to Moderate NPDR without Macular Edema (13)Mild to Moderate NPDR with Clinically Significant Macular Edema (13)Severe and Very Severe NPDR and Non-High-Risk PDR (14)High-Risk PDR (15)High-Risk PDR Not Amenable to Photocoagulation (15)Other Treatments (16)Side Effects and Complications of Treatment (16)Focal Photocoagulation for Diabetic Macular Edema (16)Scatter Photocoagulation for Severe NPDR or PDR (16)Vitrectomy (16)Follow-up (16)History (16)Provider (17)Counseling/Referral (17)APPENDIX 1. SUMMARY OF MAJOR RECOMMENDATIONS FOR CARE (18)APPENDIX 2. TREATMENT TRIAL RESULTS (20)APPENDIX 3. GLYCEMIC CONTROL (22)APPENDIX 4. COST-BENEFIT ANALYSES (23)GLOSSARY (24)RELATED ACADEMY MATERIALS (27)REFERENCES (28)INTRODUCTIONThe Preferred Practice Patterns (PPP) series of guidelines has been written on the basis of three principles.Each Preferred Practice Pattern should be clinically relevant and specific enough to provide useful information to practitioners.Each recommendation that is made should be given an explicit rating that shows its importance to the care process.Each recommendation should also be given an explicit rating that shows the strength of evidence that supports the recommendation and reflects the best evidence available.In the process of revising this document, a detailed literature search of articles in the Englishlanguage was conducted on the subject of diabetic retinopathy for the years 1997 to 2002. Theresults were reviewed by the Retina Panel and used to prepare the recommendations, which they rated in two ways. The panel first rated each recommendation according to its importance to the care process. This “importance to the care process” rating represents care that the panel thought would improve the quality of the patient’s care in a meaningful way. The ratings of importance are divided into three levels.Level A, defined as most importantLevel B, defined as moderately importantLevel C, defined as relevant but not criticalThe panel also rated each recommendation on the strength of evidence in the available literature to support the recommendation made. The “ratings of strength of evidence” also are divided intothree levels.Level I includes evidence obtained from at least one properly conducted, well-designed, randomized controlled trial. It could include meta-analyses of randomized controlled trials.Level II includes evidence obtained from the following:Well-designed controlled trials without randomizationWell-designed cohort or case-control analytic studies, preferably from more than one centerMultiple-time series with or without the interventionLevel III includes evidence obtained from one of the following:Descriptive studiesCase reportsReports of expert committees/organization s (e.g., PPP panel consensus with peer review)The evidence cited is that which supports the value of the recommendation as something thatshould be performed to improve the quality of care. The panel believes that it is important to make available the strength of the evidence underlying the recommendation. In this way, readers canappreciate the degree of importance the committee attached to each recommendation and they can understand what type of evidence supports the recommendation.The ratings of importance and the ratings of strength of evidence are given in bracketedsuperscripts after each recommendation. For instance, “[A:II]” indicates a recommendation with high importance to clinical care [A], supported by sufficiently rigorous published evidence,though not by a randomized controlled trial [II].The sections entitled Orientation and Background do not include recommendations; rather they are designed to educate and provide summary background information and rationale for therecommendations that are presented in the Care Process section. A summary of the majorrecommendations for care is included in Appendix 1.ORIENTATIONENTITYDiabetic retinopathy (ICD-9 #362.01 and 362.02)DISEASE DEFINITIONDiabetic retinopathy is a disorder of the retinal vasculature that eventually develops to somedegree in nearly all patients with long-standing diabetes mellitus. The earliest visible clinicalmanifestations of retinopathy include microaneurysms and hemorrhages. Vascular alterations can progress to retinal capillary nonperfusion, resulting in a clinical picture characterized by increased numbers of hemorrhages, cotton-wool spots, and intraretinal microvascular abnormalities (IRMA).Finally, increasing nonperfusion can lead to closure of retinal vessels and pathologic proliferation of retinal vessels, characterized by neovascularization on the disc or elsewhere. Increasedvasopermeability results in retinal thickening (edema) during the course of diabetic retinopathy.Visual loss results mainly from macular edema, macular capillary nonperfusion, vitreoushemorrhage, and distortion or traction detachment of the retina.A description of the fundus findings in various stages of diabetic retinopathy is located in theNatural History section. Important terms are defined in the Glossary.PATIENT POPULATIONThe patient population includes all patients with diabetes mellitus.ACTIVITYEvaluation and management of diabetes-related retinal disease.PURPOSEThe primary purpose of evaluating and managing diabetic retinopathy is to prevent, retard, orreverse visual loss, thereby maintaining or improving vision-related quality of life.GOALSIdentify patients at risk for developing diabetic retinopathy.Encourage involvement of the patient and primary care physician in the management of the patient’s systemic disorder, with specific attention to control of blood sugar (hemoglobin A1c),serum lipids, and blood pressure.Encourage and provide lifelong evaluation of retinopathy progression.Treat patients at risk for visual loss from diabetic retinopathy.Minimize the side effects of treatment that might adversely affect the patient’s vision and/or vision-related quality of life.Provide visual rehabilitation for patients with visual loss from the disease or refer for visual rehabilitation.BACKGROUNDEPIDEMIOLOGYDiabetic retinopathy is the leading cause of new cases of legal blindness among working-ageAmericans. An estimated 29 million Americans age 20 years or older have either diagnoseddiabetes mellitus, undiagnosed diabetes, or impaired fasting blood glucose levels; about one third are not aware that they have the disease.1For the purposes of this PPP, two forms of diabetes mellitus are recognized. Type 1, previously called juvenile-onset or insulin-dependent diabetes, is characterized by beta-cell destruction and usually leads to absolute insulin deficiency. Type 2, previously called adult-onset or noninsulin-dependent diabetes, is characterized by insulin resistance with an insulin secretory defect thatleads to relative insulin deficiency.2 Many patients with type 2 diabetes take insulin.Between 90% and 95% of patients with diabetes have type 2 diabetes. Because of the disproportionately large number of patients with type 2 diabetes, this group comprises a substantial proportion of patients with visual impairment secondary to diabetic retinopathy, even though type 1 diabetes isassociated with more frequent and more severe ocular complications.3 The increased frequency of childhood obesity may result in an increased frequency of type 2 diabetes in the pediatric agegroup.4RISK FACTORSDuration of diabetes is a major risk factor associated with the development of diabetic retinopathy.After 5 years, approximately 25% of type 1 patients have retinopathy. After 10 years, almost 60% have retinopathy, and after 15 years, 80% have retinopathy. Proliferative diabetic retinopathy, the most vision-threatening form of the disease, is present in approximately 25% of type 1 patientswith 15 years’ duration of the disease.5Of type 2 patients who have a known duration of diabetes of less than 5 years, 40% of thosepatients taking insulin and 24% of those not taking insulin have retinopathy. These rates increase to 84% and 53%, respectively, when the duration of diabetes has been documented for up to 19 years. Proliferative retinopathy develops in 2% of type 2 patients who have diabetes for less than 5 years and in 25% of patients who have diabetes for 25 years or more.6The severity of hyperglycemia is the key alterable risk factor associated with the development of diabetic retinopathy. Support for this association is found in results of both clinical trials andepidemiologic studies.7-9 There is general agreement that duration of diabetes and severity ofhyperglycemia are the major risk factors for developing retinopathy. After retinopathy is present,duration of diabetes appears to be a less important factor than hyperglycemia for progression from earlier to later stages of retinopathy.9 Intensive management of hypertension has been demonstrated to slowretinopathy progression.10, 11 There is less agreement between studies concerning the importance of other factors such as age, type of diabetes, clotting factors, renal disease, and use of angiotensin-convertingenzyme inhibitors.9, 12-14 Many of these factors are associated with the significant cardiovascularmorbidity and mortality and other complications associated with diabetes. Thus, it is reasonable toencourage patients with diabetes to be as compliant as possible with therapy of all medical aspects oftheir disease.NATURAL HISTORYDiabetic retinopathy progresses in an orderly fashion from minimal changes to more severe stages if there is no intervention. It is important to recognize the stages in which treatment may bebeneficial. Several decades of clinical research have provided excellent data on the natural course of the disease and on treatment strategies that are 90% effective in preventing the occurrence of severe vision loss. These studies include five major clinical trials: the Diabetes Control andComplications Trial (DCCT),8, 15, 16 the Diabetic Retinopathy Study (DRS),17-19 the EarlyTreatment Diabetic Retinopathy Study (ETDRS),20-31 the Diabetic Retinopathy Vitrectomy Study (DRVS),32-35 and the United Kingdom Prospective Diabetes Study (UKPDS).10, 36, 37The outcomesof these trials are solid foundations underlying the Preferred Practice Pattern for treating diabeticretinopathy. The results of these studies are presented in Appendices 2 and 3.Diabetic retinopathy in its earliest stages is called nonproliferative diabetic retinopathy (NPDR)and is characterized by retinal vascular abnormalities including microaneurysms, intraretinalhemorrhages, and cotton-wool spots. Increased retinal vascular permeability that occurs at this orlater stages of retinopathy may result in retinal thickening (edema) and lipid deposits (hardexudates). Clinically significant macular edema (CSME)is a term commonly used for retinalthickening and/or adjacent hard exudates that either involve the center of the macula or threaten tospread into it. Patients with CSME should be considered for focal laser photocoagulation,particularly if the center of the macula is already involved or if retinal thickening/adjacent hardexudates are very close to it(see Care Process).As diabetic retinopathy progresses, there is a gradual closure of retinal vessels, which results inimpaired perfusion and retinal ischemia. Signs of increasing ischemia include venousabnormalities (beading, loops, etc.), IRMA, and more severe and extensive vascular leakagecharacterized by increasing retinal hemorrhages and exudation.When these signs progress beyondcertain defined thresholds, severe nonproliferative diabetic retinopathy(severe NPDR) isdiagnosed (see Glossary for definition).Patients with this degree of retinopathy should beconsidered for possible treatment with scatter laser photocoagulation (see Care Process).The more advanced stage, proliferative diabetic retinopathy (PDR), is characterized by the onsetof neovascularization on the inner surface of the retina induced by the retinal ischemia. Newvessels at the optic disc (NVD) and new vessels elsewhere in the retina (NVE) are prone to bleed,resulting in vitreous hemorrhage. These new vessels may undergo fibrosis and contraction; thisand other fibrous proliferation may result in epiretinal membrane formation, vitreoretinal tractionbands, retinal tears, and traction or rhegmatogenous retinal detachments. When new vessels areaccompanied by vitreous hemorrhage, or when new vessels at the optic disc occupy greater than orequal to about 1/4 to 1/3 disc area, even in the absence of vitreous hemorrhage, PDR is said to bein the high-risk stage (high-risk PDR; see Glossary for definition).Neovascular glaucoma canresult from new vessels growing on the iris and anterior chamber angle structures. Patients withneovascular glaucoma or high-risk PDR should receive prompt scatter photocoagulation(see CareProcess).In an attempt to improve communication worldwide between ophthalmologists and primary carephysicians caring for patients with diabetes, an international clinical disease severity scale wasrecently developed for diabetic retinopathy and macular edema (Tables 1 and 2).38 This scale isbased on the ETDRS classification of diabetic retinopathy and on the data collected in clinicaltrials and epidemiologic studies of diabetic retinopathy. However, the scheme remains to bevalidated.TABLE 1International Clinical Diabetic Retinopathy Disease Severity ScaleProposed Disease Severity Level Findings Observable upon Dilated OphthalmoscopyNo apparent retinopathy No abnormalitiesMild nonproliferative diabetic retinopathy Microaneurysms onlyModerate nonproliferative diabetic retinopathy More than just microaneurysms but less than severe NPDRSevere nonproliferative diabetic retinopathy♦ ♦ ♦ More than 20 intraretinal hemorrhages in each of four quadrants Definite venous beading in two or more quadrants Prominent IRMA in one or more quadrantsAnd no signs of proliferative retinopathy Proliferative diabetic retinopathy One or both of the following:♦ ♦ Neovascularization Vitreous/preretinal hemorrhageIRMA = intraretinal microvascular abnormalities; NPDR = nonproliferative diabetic retinopathyTABLE 2 International Clinical Diabetic Macular Edema Disease Severity ScaleProposed Disease Severity Level Findings Observable upon Dilated OphthalmoscopyDiabetic macular edema apparently absent Diabetic macular edema apparently present No apparent retinal thickening or hard exudates in posterior pole Some apparent retinal thickening or hard exudates in posterior pole If diabetic macular edema is present, it can be categorized as follows:Proposed Disease Severity LevelFindings Observable upon Dilated Ophthalmoscopy* Mild diabetic macular edema: Some retinal thickening or hard exudates in posterior pole butdistant from the center of the maculaModerate diabetic macular edema: Retinal thickening or hard exudates approaching the center ofthe macula but not involving the centerDiabetic macular edema present ♦Severe diabetic macular edema: Retinal thickening or hard exudates involving the center of themacula ♦ ♦ * Hard exudates are a sign of current or previous macular edema. Diabetic macular edema is defined as retinal thickening; this requires a three-dimensional assessment that is best performed by dilated examination using slit-lamp biomicroscopy and/or stereo fundus photography.PREVENTION AND EARLY DETECTIONAlthough a healthy lifestyle with exercise and weight control may decrease the risk of developing diabetes in some patients,39, 40 in many cases diabetes cannot be prevented. In contrast, in many cases the blinding complications of diabetes mellitus can be prevented or moderated. Treatment can yield significant cost savings compared with the direct costs for those disabled by vision loss (see Appendix 4). Analyses from two clinical trials show that the treatment for diabeticretinopathy may be 90% effective in preventing severe vision loss (visual acuity less than 5/200) with current treatment strategies.41 Although effective treatment is available, the number of patients with diabetes referred by their primary care physicians for ophthalmic care is far below the guidelines of the American Diabetes Association and the American Academy ofOphthalmology.42 In a community-based intervention trial, at enrollment 35% of participants did not follow the vision care guidelines; two thirds of this group reported no eye examination in the year prior to enrollment and one third had an undilated examination.43In one epidemiologic study of over 2000 diabetes patients, 11% of type 1 patients and 7% of type 2 patients with high-risk PDR had not been seen by an ophthalmologist within 2 years.44 In this study, 46% of eyes with high-risk PDR had not received photocoagulation surgery.44 According to the National Committee for Quality Assurance’s Health Plan Employers Data Information Set 3.0 System, the average rate of annual eye examinations for patients with diabetes was 45% across participating health plans in 2000. Among prepaid health plan enrollees, 77% of patients with diabetes received an eye examination over a 3-year study period.45 A longitudinal analysis of Medicare claims data for beneficiaries age 65 years or older found that 50% to 60% had annual eye examinations in a 15-month period.46 Ophthalmologists, physicians who care for patients with diabetes, and patients themselves need to be educated about indications for referral.Recommended intervals for eye examinations for patients with diabetes are given in Table 3.TABLE 3Recommended Eye Examination Schedule for Patients with Diabetes Mellitus Diabetes Type Recommended Time ofFirst ExaminationRecommended Follow-up* Type 1 5 years after onset5[A:II] Yearly5 [A:II]Type 2 At time of diagnosis6 [A:II] Yearly6 [A:II]Prior to pregnancy (type 1 or type 2) Prior to conception or early in the firsttrimester47-49 [A:I]No retinopathy to mild or moderate NPDR: every 3–12 months47-49 [A:I]Severe NPDR or worse: every 1–3 months47-49 [A:I]* Abnormal findings may dictate more frequent follow-up examinations.NPDR = nonproliferative diabetic retinopathyThe primary prevention and screening process for diabetic retinopathy varies according to the age of onset of the disease. Several forms of retinal screening with standard fundus photography ordigital imaging, with and without dilation, are being investigated as a means of detectingretinopathy early, and they warrant further evaluation.50Some studies have shown that screening to identify sight-threatening retinopathy with photography is more sensitive than clinicalexamination with ophthalmoscopy.51-54 It is not clear whether the new digital photographytechniques (e.g., single-field, 45-degree photo) are as sensitive and specific as traditional standard seven-field stereoscopic 30-degree fundus photographs for determining the level of diabeticretinopathy.55 Most digital nonmydriatic cameras lack stereoscopic capability, which is useful for identifying subtle neovascularization and macular edema.42 However, digital nonmydriaticcameras that operate stereoscopically have been validated against fundus photography and mayeventually prove to be useful tools in future studies. At this time it is not clear that photographic screening programs achieve a greater reduction in vision loss compared with routine community care in areas where access to ophthalmologists is straightforward.42 Of course, such screeningprograms have great value in circumstances in which access to ophthalmic care is limited.53, 55 At this time, these technologies are not considered a replacement for a comprehensive eye evaluation by an ophthalmologist experienced in managing diabetic retinopathy.Ophthalmologists can play an important role in diabetic care apart from treating eye disease.Patients can be counseled about the importance of blood glucose and blood pressure control, for example, at the time of the eye examination.The results of the DCCT showed that the development and progression of diabetic retinopathy in patients with type 1 diabetes can be delayed if glucose concentrations are maintained in the near-normal range (see Appendix 3).15 After 3 years of intensive treatment to reduce glucose levels, the DCCT showed that among patients without retinopathy, the development of any retinopathy was reduced by 75% but not prevented completely over the 9-year course of the study. The benefit of strict glucose control also was evident in patients with existing retinopathy (50% reduction in the rate of progression of retinopathy compared with controls). At the 6- and 12-month visits, a small adverse effect of intensive treatment on retinopathy progression was seen, similar to that described in other trials of intensive glucose control. This small adverse effect was a transient earlyworsening of the retinopathy in the intensive treatment group within the first 2 years of treatment, with no effect on visual acuity. Beyond 3.5 years of follow-up, the risk of progression was fivetimes lower with intensive insulin treatment than with conventional treatment.Evidence about the effects of controlling hyperglycemia in type 2 patients comes fromobservational data as well as randomized clinical trials. Definitive results were seen in theUKPDS,37, 56 a randomized, controlled clinical trial of blood glucose control in 3867 patients with newly diagnosed type 2 diabetes. Intensive blood glucose control by either the sulfonylureas orinsulin decreased the risk of microvascular complications but not the risk of macrovasculardisease. There were no adverse effects of the individual drugs on the cardiovascular outcome. In this study, there was a 29% reduction in the need for retinal photocoagulation surgery in the group with intensive glucose therapy compared with those with conventional treatment (relative risk,0.71; 95% confidence interval, 0.53–0.96; P=0.003).Also in the UKPDS, 1148 patients with both diabetes and hypertension were randomly assigned to antihypertensive treatment.10 Additional analyses from this nested trial of antihypertensivemedications (captopril, an angiotensin-converting enzyme inhibitor, or atenolol, a beta blocker) showed that tight blood pressure control achieved a clinically important reduction in the risk of deaths related to diabetes and in the risk of progression of diabetic retinopathy. There was a 34% reduction in the risk of progression of retinopathy from baseline by two or more steps by a median of 7.5 years (P=0.004) and a 47% reduced risk of decreased vision by three lines on the ETDRS chart (P=0.004). There was no difference in the progression of retinopathy or the final visualacuity in those patients treated with an angiotensin-converting enzyme inhibitor compared with those treated with a beta blocker.It is important to educate all patients with diabetes about the disease and to stress the value ofmaintaining blood glucose (as monitored by hemoglobin A1c) as near normal as is safely possible.The results of the DCCT showed that lowering blood glucose reduces other end-organcomplications as well, including nephropathy and neuropathy (see Appendix 3). The results of the UKPDS demonstrate the value of controlling blood glucose and blood pressure in all patients with type 2 diabetes.Medical treatment such as aspirin therapy has been evaluated for the prevention and retardation of diabetic retinopathy. The ETDRS found no evidence that aspirin therapy retards or accelerates the progression of diabetic retinopathy22 or that it causes more severe or more long-lasting vitreous hemorrhages in patients with PDR.57CARE PROCESSThe care process for diabetic retinopathy includes a medical history, an ophthalmic examination, and vigilant follow-up. Early detection of retinopathy depends on educating patients with diabetes as well as their families, friends, and eye care providers about the importance of regular eyeexamination even though the patient may be asymptomatic. Patients with diabetes mellitus without diabetic retinopathy should be encouraged to have annual dilated eye examinations to detect the onset of diabetic retinopathy.[A:III] Patients should also be informed that effective treatment fordiabetic retinopathy depends on timely intervention, despite good vision and no ocularsymptoms.[A:III] (The recommended timing of the first ophthalmic exam and subsequent follow-up exams for patients with diabetes is given in the section Examination Schedule and in Table 3.)Patient education about the importance of maintaining near-normal glucose levels and near-normal blood pressure and lowering serum lipid levels is an important aspect of the care process.[A:III]Many patients are still not aware of the importance of maintaining good glucose control andmonitoring serum glycosylated hemoglobin levels. Aspirin may be used without concern forworsening diabetic retinopathy by patients with diabetes who require aspirin for other medicalindications and have no contraindications.22, 57 [A:I]PATIENT OUTCOME CRITERIAPatient outcome criteria include the following:Improvement or stabilization of visual functionImprovement or stabilization of vision-related quality of lifeCoordination of care management to achieve optimal glycemic controlDIAGNOSISThe initial examination for a patient with diabetes mellitus includes all features of thecomprehensive adult medical eye evaluation,58 with particular attention to those aspects relevant to diabetic retinopathy.。
从新版美国眼科临床指南(PPP)看成人白内障手术的意义与指征
作者单位:复旦大学附属眼耳鼻喉科医院眼科 上海 200031 通信作者:卢奕(Email:luyieent@126.com) DOI:10.14166/j.issn.16712420.2018.05.002
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ChinJOphthalmolandOtorhinolaryngol,September2018,Volume18,Number5
【Keywords】 PreferredPracticePattern;Cataractsurgery;Interpretation;Surgicalindications;Cataract surgeryrate
白内障手术的意义和指征正在经历着显著的变 化。最 新 的 美 国 眼 科 临 床 指 南 (Preferred Practice Pattern,PPP)《成 人 白 内 障 手 术》(2016年 版)(以 下 PPP均特指 该 部 分 )[1],系 统 阐 述 了 白 内 障 手 术 的 收 益、手术指征的变迁、新的评估手段以及白内障手术的 医学经济学问题。基于 PPP对这些问题的阐述,本文 结合国内外现状,分析当前形势下白内障手术指征的 变化及在这一变化过程中存在的焦点问题,与眼科同 仁共同探讨。
【关键词】 眼科临床指南;白内障手术;解读;手术指征;白内障手术率
DiscussiononthesignificanceandindicationsofadultcataractsurgerybasedonthePreferredPracticePattern oftheUnitedStates ZHENGTianyu,LUYi. DepartmentofOphthalmology,EyeEarNoseandThroatHospitalof FudanUniversity,Shanghai200031,China Correspondingauthor:LUYi,Email:luyieent@126.com
眼科学主要研究及作用概述
American Academy of Ophthalmology- 美国眼科学会提供眼睛解剖、保健和疾病信息。
Association for Research in Vision and Ophthalmology (ARVO)- 视觉和眼科学研究学会(ARVO)的目标是鼓励和支持视觉和眼科学的研究、培训、出版物和有关知识的普及。
International Council of Ophthalmology's Eye Site, The- 国际眼科学委员会为眼科学家和公众提供全世界的眼科学相关信息和资源,预防失明和恢复视觉。
OphthoGuide- 眼科学搜索引擎和眼科疾患medline搜索。
Review of Ophthalmology- 眼科学综述是为眼科学家及相关人员提供的月刊,还涉及医学教育和研究。
Asian Journal of Ophthalmology- 亚洲眼科学杂志是为眼科学家提供的季刊。
American Association for Pediatric Ophthalmology & Strabismus- 美国儿童眼科学和斜视协会。
American Board of Ophthalmology- 美国眼科学委员会为美国眼科医生提供证书和换发证书的信息,以提高眼科医疗水平。
Digital Journal of Ophቤተ መጻሕፍቲ ባይዱhalmology- 眼科学数字杂志由哈佛医学院附属眼科和耳科医院主办。
American Journal of Ophthalmology- 美国眼科学杂志。文章的作者在线回答问题和评论他们的科研工作。
糖尿病视网膜病变诊治规范美国眼科学会临床指南解读
四、结论
四、结论
DR是一种严重的眼部并发症,如不及时治疗会导致视力下降甚至失明。SCL作 为美国眼科学会制定的DR诊治规范,具有极高的科学性和规范性,为全球的DR诊 治提供了重要的参考。在我国,虽然DR的发病率逐年上升,但对其诊治仍存在诸 多问题和挑战。我们应该积极应对,加强医生培训,提高医疗技术水平,加强公 众健康教育,以期能够更好地预防和控制DR的发病,提高人民群众的生活质量。
二、SCL的制定原则和主要内容
(4)激光治疗:用激光束凝固视网膜病变区域,以减轻视网膜水肿、减少新 生血管的产生。
二、SCL的制定原则和主要内容
(5)手术治疗:对于严重的DR患者,可能需要手术治疗,如玻璃体切割术等。
二、SCL的制定原则和主要内容
3.药物选择:SCL提出了一些可用于DR治疗的药物,包括抗血管内皮生长因子 (VEGF)药物如贝伐单抗和雷珠单抗等,以及一些抗炎药物如地塞米松等。同时, 也强调了根据病情选择合适药物的重要性。
糖尿病视网膜病变诊治规范美 国眼科学会临床指南解读
目录
01 一、DR的基本概念、 流行情况和危害
03 四、结论
02
二、SCL的制定原则 和主要内容
内容摘要
糖尿病视网膜病变(DR)是糖尿病患者最常见的眼部并发症之一,也是导致 视力损害和失明的主要原因之一。为了规范DR的诊治,美国眼科学会(AAO)制 定了相关的诊治规范(SCL),以期提高医生的诊治水平,保障患者的视觉健康。 本次演示将介绍DR的基本概念、流行情况和危害,并解读SCL的实际应用价值, 为我国的DR诊治提供参考。
谢谢观看
新版美国眼科临床指南(PPP)对间歇性外斜视诊治的指导及解读
得分
项目
家庭评估
0分 从未观察到斜视 /闭一眼
1分 偶尔观察到看远时斜视 /闭一眼(<50%的时间)
2分 经常观察到看远时斜视 /闭一眼(>50%的时间)
3分 看远和看近均有斜视 /闭一眼
诊室评估 -看近 0分 仅在遮盖试验时表现出斜视,不需要眨眼或重新注视
便会恢复融合 1分 在遮盖试验后需眨眼或重新注视恢复融合
Haggerty等[3]提出了间歇性外斜视的纽卡斯眼位 控制能力评分(NewcastleControlScore,NCS,表 1)标 准,在 此 基 础 上 制 定 了 修 订 版 NCS(revisedNCS, RNCS,表 2)标准[4],为患者日常和就诊时的眼位控制 能力进行评分,对间歇性外斜视患者的病情评估和手 术时机的选择具有重要意义,是临床常用的评价方法。
【Abstract】 Intermittentexotropiaisthemostcommontypeofexotropia.Basedonthe2017editionofthe PreferredPracticePattern(PPP),thispapermakesanunderstandingofthestandardizeddiagnosisandtreatmentof intermittentexotropiafrom fouraspects:medicalhistory,specializedexaminationofstrabismus,classificationand treatment.
2分 自发性表现出斜视或者融合中断无法恢复
诊室评估 -看远 0分 仅在遮盖试验时表现出斜视,不需要眨眼或重新注视
便会恢复融合 1分 在遮盖试验后需眨眼或重新注视恢复融合
对比美国眼科临床指南(PPP)过敏性结膜炎分册与《我国过敏性结膜炎诊断和治疗专家共识(2018年)》
中国眼耳鼻喉科杂志2018年7月第18卷第4期227•眼科临床指南(P P P)解读•对比美国眼科临床指南(PPP)过敏性结膜炎分册与《我国过敏性结膜炎诊断和治疗专家共识(2018年)》洪佳旭徐建江【摘要】长期以来,美国眼科临床指南(p p p)的过敏性结膜炎相关论述是各国眼科学者诊治过敏性结膜炎的重要参考之一。
但应当看到,该p p p内容包含各种类型结膜炎,尤以感染性结膜炎为主,过敏性结膜炎诊断与治疗的阐述缺乏细则。
因此,中华医学会眼科学分会角膜病学组于2017年组织并撰写了《我国过敏性结膜炎诊断和治疗专家共识(2018年)》(简称《专家共识》)。
该《专家共识》概括了过敏性结膜炎诊疗相关研究的前沿和现状,更有助于推动我国过敏性结膜炎的规范化诊疗。
主要要点包括:吸收并肯定了欧美过敏性结膜炎诊疗指南的精髓,将过敏性结膜炎分为5个亚类,强调在临床上区分增殖性与非增殖性过敏性结膜炎;提出了一套基于专家临床经验的分类方法,有助于疾病的定量分级;强调了双效药物作为首选治疗的重要性,提出使用皮质类固醇类药物和免疫抑制剂治疗过敏性结膜炎的原则及方案。
考虑到文章篇幅,本文结合美国眼科学会结膜炎诊疗指南(P PP),针对我国《专家共识》的重点进行择要解读,以期与国内眼科同道分享过敏性结膜炎的最新诊疗经验。
【关键词】眼科临床指南;过敏性结膜炎;中华医学会眼科学分会角膜病学组Comparison of the consensus of allergic conjunctivitis from China Cornea Society witli the Pre Pattern of conjunctivitis HONG Jia-xu, XU Jian-jiang. Department of Ophthalmology , Eye Ear Nose and ThroatHospital of Fudan University , Shanghai 200031, China.Corresponding author:HONG Jia-xu , Email:jiaxu_hong@ 163. com【A bstract】For a long time, the Preferred Practice Pattern ( PPP) of American Academy of Ophthalmologyrelated to allergic conjunctivitis is widely recommended for the diagnosis and treatment of allergic con physicians. However , the PPP content contains various types of conjunctivitis , mainly infections conjunctivitis yetaiergic conjunctivitis lack of d etailed rules. China Cornea Society organized and wrote the expert consensus of allergicconjunctivitis in China in 2017. The expert consensus summarizes the frontier and present situ aiergic conjunctivitis , and aims to promote the standardized diagnosis and treatment of allergic conjunctivitis in China. Firstly , we divide allergic conjunctivitis into 5 subtypes , emphasizing on the clinical differentiation of proliferative andnon-proliferative allergic c onjunctivitis. Secondly , a classification method based on expert clinical experience isproposed , which contributes to the quantitative grading of diseases. Thirdly , the importance first choice of t reatment is emphasized. Finally , we put forward the principle and scheme of using steroids and immunosuppressive drugs f or allergic conjunctivitis. Taking into account the length of the article , compared withPreferred Practice Pattern of Conjunctivitis , this article aimed at key points of the Chinese expert consensus , with aview to share with ophthalmologists about the latest experience in diagnosis and treatment of allergic conjunctivitis.【Key words】Preferred Practicc Pattern; Allergic conjunctivitis; China Cornea Society过敏性结膜炎的诊断和治疗在我国相当长一段时 间内仍然多数依靠眼科医师的临床经验。
解读新版美国眼科临床指南(PPP):角膜屈光手术更安全
解读新版美国眼科临床指南(PPP):角膜屈光手术更安全周行涛;李美燕【摘要】我国是近视大国,每年接受角膜屈光手术的人数超过70万人.随着手术人数的不断增加,对手术的安全性和术后的视觉质量提出了更高的要求.新版(2017年)美国眼科临床指南(PPP)对屈光不正、屈光手术包括近视、老视进行了更新.解读PPP是一件十分有意义的事情,可进一步促进我国的屈光手术更安全、规范地开展.PPP解读《屈光不正与屈光手术》已获得人民卫生出版社的立项支持,预计明年会出版与大家见面.【期刊名称】《中国眼耳鼻喉科杂志》【年(卷),期】2018(018)006【总页数】3页(P371-373)【关键词】眼科临床指南;屈光手术;屈光不正;解读;近视;老视【作者】周行涛;李美燕【作者单位】复旦大学附属眼耳鼻喉科医院眼科上海 200031;复旦大学附属眼耳鼻喉科医院眼科上海 200031【正文语种】中文自1987年Trokel报道准分子激光以来,激光手术一直处于不断发展中。
从最初的表层切削准分子激光屈光性角膜切削术(photorefractive keratectomy, PRK)到板层手术准分子激光原位角膜磨镶术(laser in situ keratomileusis, LASIK),再到“薄角膜瓣”概念的前弹力层下角膜磨镶术(sub-Bowmans keratomileusis, SBK),从乙醇法准分子激光上皮瓣下角膜磨镶术(laser subepithelial keratectomy, LASEK)到机械法准分子激光上皮瓣下角膜磨镶术(epipolis laser in situ keratomileusis, epi-LASIK)为代表的优化表层切削,到飞秒激光辅助制瓣的飞秒激光LASIK(femtosecond laser assisted LASIK, FS-LASIK), 再到2010年首次报道的飞秒激光小切口透镜取出术(small incision lenticule extraction, SMILE),新的手术方式不断出现,手术的有效性、安全性、预测性和稳定性明显提升,术后患者的舒适度明显改善。
眼科专业术语缩写
眼科专业术语缩写以下是眼科专业术语的一些常见缩写:1. AMD - 年龄相关性黄斑变性(Age-related Macular Degeneration)2. ARMD - 年龄相关性黄斑变性(Age-related Macular Degeneration)3. BCVA - 最佳矫正视力(Best Corrected Visual Acuity)4. CME - 黄斑水肿(Cystoid Macular Edema)5. CRVO - 中央视网膜静脉阻塞(Central Retinal Vein Occlusion)6. DED - 干眼病(Dry Eye Disease)7. DME - 糖尿病黄斑水肿(Diabetic Macular Edema)8. ERG - 视觉诱发电位(Electroretinogram)9. IOP - 眼压(Intraocular Pressure)10. LASIK - 激光角膜磨镶术(Laser-Assisted in Situ Keratomileusis)11. OCT - 光相干断层扫描(Optical Coherence Tomography)12. PVD - 玻璃体后脱离(Posterior Vitreous Detachment)13. RD - 视网膜脱离(Retinal Detachment)14. RP - 视网膜色素变性(Retinitis Pigmentosa)15. ROP - 视网膜增生症(Retinopathy of Prematurity)16. SLT - 选择性激光三刀(Selective Laser Trabeculoplasty)17. VA - 视力(Visual Acuity)18. VF - 视野(Visual Field)这只是一小部分眼科专业术语的缩写,还有很多其他的缩写术语存在。
一个亚洲机构相对37932例近视眼夸10年的LASIK的前瞻性审核成果Ophthalmology 2010 Jun.117(6) p1236-1244
一个亚洲机构相对37932例近视眼夸10年的LASIK的前瞻性审核成果LeonardH.Y uen,MD,MPH, WingKwongChan,FRCOphth,FRCS(Ed), JaneKoh,Adv.Dip.Stat.(Sp),JodhbirS.Mehta,FRCOphth,FRCS(Ed), DonaldT.Tan,FRCOphth,FRCS(Ed), fortheSingLasikResearchGroup研究目的:本研究旨在探讨LASIK作为一种近视眼治疗手术的有效性,可预测性和安全性。
并通过在亚洲人中跨10年大规模,前瞻性的临床审计工作评估了该手术的研究结果和趋势。
研究设计:前瞻性,非随机,单中心,多外科医生的研究参与者:这项研究包括了从1998年到2007年在新加坡National Eye Centre接受过LASIK 近视眼手术的19753名患者的37932例眼部手术。
研究方法:所有接受LASIK近视眼手术中的术前和术后屈光度,UCVA,BCVA都备档在案。
主要观察指标:分别测定根据等效球分类法(SE)不超过-5.00diopters(D)的轻度近视,大于-5.00D小于-10.0D的中度近视,大于等于-10.00D的高度近视的安全性,有效性,屈光可预测性,治疗的趋势,重复治疗率以及轻度并发症。
研究结果:患者的平均年龄为32岁(平均在33.0+/-7.9年)。
包括6832名男性(34.6%)和12921名女性。
患者主要为华裔(90.5%)。
平均随访时间为68.8天。
平均球面误差修正为-5.90+/-2.57D(中间值为-5.625D),并按照结果分类为低、中和高度近视。
自2000年以来,UCVA达到20/40的都在90%以上,并且有72.8%达到了20/20。
在过去的4年间,超过93.0%的眼视力达到了+/-1.00D的目标。
自该项研究开始以来,安全系数一直逐步提高,最好的安全指数结果是在2007年; 在BCVA的Snellen视力检查中损失1行的为2.4%,损失2行的是0.1%。
新版美国眼科临床指南(PPP)对间歇性外斜视诊治的指导及解读
新版美国眼科临床指南(PPP)对间歇性外斜视诊治的指导及解读刘艳;赵晨【摘要】间歇性外斜视是临床最常见的外斜视类型.本文基于2017年版的美国眼科临床指南(PPP)《内斜视和外斜视》分册,从病史、斜视专科检查、分型、治疗4个方面对间歇性外斜视的规范化诊治进行解读.【期刊名称】《中国眼耳鼻喉科杂志》【年(卷),期】2019(019)001【总页数】3页(P6-8)【关键词】眼科临床指南;间歇性外斜视;诊断;治疗【作者】刘艳;赵晨【作者单位】复旦大学附属眼耳鼻喉科医院眼科上海200031;复旦大学附属眼耳鼻喉科医院眼科上海200031【正文语种】中文间歇性外斜视是临床最常见的外斜视类型,不同种族间外斜视的发生率有明显差异。
我国的流行病学调查显示,间歇性外斜视的发病率为3.42%~3.9%[1-2]。
间歇性外斜视常在3岁前发病,但是早期表现为间歇性,并且儿童检查欠配合而不易被察觉,所以发现时间可有早晚。
当患儿疲劳、注意力不集中或生病时,融合代偿功能减弱,就容易出现斜视。
间歇性外斜视患儿在发病初期表现为视远时出现外斜,而视近时仍可维持正常眼位和双眼单视功能。
如果不及时治疗,可发展为恒定性外斜视,最终完全丧失双眼单视功能。
另外,若不治疗斜视,会影响患儿日常的社交,长期将影响其心理发育。
新版眼科临床指南(Preferred Practice Pattern ,PPP;下文均特指PPP《内斜视和外斜视》分册2017年版)增加了外斜视对儿童身心健康的影响,强调手术干预可改善儿童生活质量及双眼视功能。
本文从病史、斜视专科检查、分型、治疗4个方面阐述新版指南中对间歇性外斜视的指导及解读。
1 病史间歇性外斜视的病史应包括清醒时眼位偏斜的频率,是否可以控制眼位的偏斜,眼位偏斜发生的时间(如劳累、生病或观看远距离物体的时候),左、右眼交替注视和主斜眼。
根据外斜视的控制情况,可进行病情严重程度的分级评价。
外斜视进展的指标包括控制情况变差、立体视觉下降和(或)发生抑制。
美国研究报告儿童视力
美国研究报告儿童视力美国研究报告儿童视力引言近年来,儿童视力问题在全球范围内呈现出明显的增长趋势。
特别是在美国,儿童视力问题已经成为一个备受关注的社会问题。
本文将通过对美国相关研究报告的分析,探讨儿童视力问题的原因、影响以及可能的解决方法。
1. 儿童视力问题的现状据美国眼科学会的调查数据显示,近两十年来,儿童近视的发生率呈现出明显的上升趋势。
根据美国国家眼病研究所的数据,目前在美国有超过30%的儿童在入学时已经存在近视问题,这个数值比二十年前的数据增加了一倍。
2. 儿童视力问题的可能原因2.1 近距离用眼时间过长现代社会中,孩子们大多数时间都在近距离使用电子设备,如智能手机、电脑、平板等。
长时间持续使用这些设备会导致眼睛过度疲劳,从而增加近视的风险。
2.2 家庭遗传因素研究表明,近视和遗传有一定的关联性,如果父母或其他近亲存在近视问题,那么孩子也容易遗传这个问题。
2.3 环境因素环境因素也对儿童视力产生影响。
例如,过亮或过暗的光线、不良的阅读习惯等都会对儿童的视力产生不利影响。
3. 儿童视力问题的影响儿童视力问题不仅会影响孩子的生活质量,还会对他们的学习和发展产生直接的影响。
3.1 学习成绩下降近视会导致孩子在课堂上无法清晰看清黑板或书本上的内容,从而影响他们的学习成绩。
3.2 眼部疲劳和不适长时间使用电子设备和阅读会导致眼睛疲劳和不适感,如干涩、痒等,从而影响孩子的学习和生活。
3.3 心理压力增加近视问题可能导致孩子对自己的形象产生不满,从而增加心理压力,甚至影响他们与同伴的交往。
4. 解决儿童视力问题的方法4.1 视力保护教育提高儿童和家长对视力保护的意识,教育他们正确使用电子设备,注意用眼卫生。
建立科学的用眼习惯,定期进行视力保健检查,及时发现和纠正视力问题。
4.2 控制近距离用眼时间限制孩子使用电子设备的时间,并鼓励他们进行室外活动。
每隔一段时间,让孩子远离电子屏幕,休息眼睛。
4.3 调整学习环境学校和家庭应提供良好的照明条件,避免光线过强或过弱。
美国临床实践规范-近视进展的预防
近视进展的预防大多数近视在儿童期和青春期发生和发展。
旨在预防或者减缓近视进展的治疗包括光学矫正、使用睫状肌麻痹剂、降眼压眼药水、角膜接触镜、视觉训练以及加强营养。
光学矫正光学矫正的形式包括双焦眼镜、多焦眼镜、在近距离工作时去掉视远的眼镜,这些形式的光学矫正已经被推荐用来减少调节(accommodation),而调节被认为是导致近视进展的机制。
很多关于光学矫正的研究是回顾性的图表总结(retrospective chart reviews),这种方法存在很多缺陷,比如患者群体是不同的、观察者间的误差不能控制、随访差、研究对象的规模太小以至于不能提供充分的统计学数据证实微小的治疗效果是有意义的。
最近的一些研究中出现了随机对照的临床研究。
有5项研究比较了双焦眼镜(屈光度范围为+1.00D到+2.00D)和单视矫正(monovision)眼镜对于近视儿童的效果,其中4项研究没有能够证明两种方法对近视进展有显著差异。
一项以75名内隐斜儿童为对象的研究发现,一半使用+1.5D双焦眼镜的儿童与对照比较近视进展程度有轻微的降低,刚刚达到统计学显著差异的水平(p=0.046,在对年龄进行校正后)。
一项最近的研究对近视儿童使用多焦眼镜和单视矫正远距离眼镜进行了比较,没有发现近视加重的比例有显著的统计学差异。
另一项关于使用多焦接触镜的研究正在进行中。
总之,除了一项小型临床研究,并没有证据显示光学矫正能够预防近视的进展。
睫状肌麻痹滴眼剂使用阿托品滴眼液长时间被作为预防近视进展的一种治疗。
阿托品抑制调节,而调节可能对眼球施加力量使得眼轴变长。
在一项动物研究中,还发现阿托品能够抑制生长因子,这些生长因子能使眼轴变长,而与调节无关。
尽管较早的关于阿托品对近视儿童作用的临床研究显示其有一些效果,但是这些研究存在着方法学上的问题,限制了这些结论的得出。
最近三个在台湾进行的随机、对照临床试验提供了一些合理的证据表明滴用阿托品滴眼剂延缓了学校内儿童的近视进展。
美国眼视光诊疗模式简介
美国眼视光诊疗模式简介
视光医学(optometry)最早起源于欧洲,在欧美发达国家已经历
了100多年,发展到现在的眼视光学是一门以保护人眼视觉健康为主要内容的医学领域学科,是以眼科学和光学、视觉科学为主,结合现代医学、生理光学、应用光学、生物医学工程等知识所构成的一门专业性强、涉及面广的交叉学科。
打个简单的比方,把眼睛比作一部照相机,那专门修理相机镜头部分的工作就是眼视光医学的任务。
那么从事眼视光医学工作的医生,必须要掌握眼科医学和视光学两门基础知识和技能才能够胜任。
国外眼视光矫治服务模式的介绍:在美国是设置OD医生(Optometry Doctor即视光医生)制度,意思是视光医生在学校学习时不但要学习眼科医学同时也要学习视
光学,机构能否从事屈光矫治服务首先要看医生自身是否具备必要的相应资质,没有OD医生,不允许开设眼镜店等视力矫治机构。
在日本是厚生劳动省发布指导规范,使得眼科诊所与隐形眼镜店伴生的模式通行全日本。
将眼科医生和视光师分成两个专业并存服务,医生查眼睛,视光师验光配镜明确分工,眼镜店必须有医生的处方才可以卖隐形眼镜。
美国和日本建立上述眼科医生(或眼科诊所)与视力矫正机构伴生的目的,就是为了能够在制度上保证给患者提供安心、安全和有效准确的矫治服务。
我国目前眼视光医学行业,尚处在缺医少规的阶段,特别是处于未系统立法进行管理的状态。
虽然美国、日本的两个模式是现今世界
上管理最到位的也是最有效最安全的矫治服务模式,但在我国实现起来还需要时日,急切之下不能应对与满足我国亿万患者需求安心、安全、有效准确矫治服务的现状。
眼科疾病英文单词集
deep keratitis 深层角膜炎interstitial keratitis 基质性角膜炎曾用名“实质性角膜炎”。
neuroparalytic keratitis 神经麻痹性角膜炎keratitis sicca 干燥性角膜炎sclerosing keratitis 硬化性角膜炎exposure keratitis 暴露性角膜炎曾用名“兔眼性角膜炎(lagophthalmic keratitis)”。
traumatic keratitis 外伤性角膜炎keratoconjunctivitis 角膜结膜炎epidemic keratoconjunctivitis, BKC 流行性角膜结膜炎acute hemorrhagic keratoconjunctivitis 急性出血性角膜结膜炎phlyctenular keratoconjunctivitis 泡性角膜结膜炎keratoconjunctivitis sicca 干燥性角膜结膜炎corneal ulcer 角膜溃疡catarrhal corneal ulcer 卡他性角膜溃疡atheromatous corneal ulcer 粥样角膜溃疡pseudomonas aeruginosa corneal ulcer 铜绿假单胞菌性角膜溃疡又称“绿脓杆菌性角膜溃疡(pyocyaneal corneal ulcer)”。
?serpiginous corneal ulcer, Saemisch corneal ulcer 匍行性角膜溃疡曾用名“前房积脓性角膜溃疡(hypopyon corneal ulcer)”。
trachomatous corneal ulcerm 沙眼性角膜溃疡rodent corneal ulcer, Mooren ulcer 蚕食性角膜溃疡曾用名“慢性匍行性角膜溃疡(chronic serpiginous corneal ulcer)”。
眼科英文病历( 眼科检查)
Sample History and Physical Note Charting Plus™ - Electronic Medical Records Note for John Doe on 6/6/02 - Chart 1124Chief Complaint: This 26 year old male presents today for a complete eye examination.Allergies: Patient admits allergies to aspirin resulting in disorientation, GI upset.Medication History: Patient is currently taking amoxicillin-clavulanate 125 mg-31.25 mg tablet, chewable medication was prescribed by A. General Practitioner MD, Adrenocot 0.5 mg tablet medication was prescribed by A. General Practitioner MD, Vioxx 12.5 mg tablet (BID).PMH: Past medical history is unremarkable.Past Surgical History: Patient admits past surgical history of (+) appendectomy in 1989.Social History: Patient denies alcohol use. Patient denies illegal drug use. Patient denies STD history. Patient denies tobacco use.Family History: Unremarkable.Review of Systems:Eyes: (-) dry eyes (-) eye or vision problems (-) blurred vision Constitutional Symptoms: (-) constitutional symptoms such as fever, headache, nausea, dizziness Musculoskeletal: (-) joint or musculoskeletal symptomsEye Exam: Patient is a pleasant, 26 year old male in no apparent distress who looks his given age, is well developed and nourished with good attention to hygiene and body habitus.Visual Acuity:Visual acuity - uncorrected: OD: 20/10 OS: 20/10 OU: 20/15Refraction:Lenses - final:OD: +0.50 +1.50 X 125 Prism 1.75OS: +6.00 +3.50 X 125 Prism 4.00 BASE IN FresnelAdd: OD: +1.00 OS: +1.00OU: Far VA 20/25Pupils: Pupil exam reveals round and equally reactive to light and accommodation.Motility: Ocular motility exam reveals gross orthotropia with full ductions and versions bilateral. Visual Fields: Confrontation VF exam reveals full to finger confrontation OU.IOP: IOP Method: applanation tonometry OD: 10 mmHg Medications: Alphagan; 0.2% Condition: improving.Keratometry:OD: K1 35.875K2 35.875OS: K1 35.875K2 41.875Lids/Orbit: Bilateral eyes reveal normal position without infection. Bilateral eyelids reveals white and quiet.Slit Lamp: Corneal epithelium is intact with normal tear film and without stain. Stroma is clear and avascular. Corneal endothelium is smooth and of normal appearance.Anterior Segment: Bilateral anterior chambers reveal no cells or flare with deep chamber.Lens: Bilateral lenses reveals transparent lens that is in normal position.Posterior Segment: Posterior segment was dilated bilateral. Bilateral retinas reveal normal color, contour, and cupping.Retina: Bilateral retinas reveals flat with normal vasculature out to the far periphery. Bilateral retinas reveal normal reflex and color.Test Results: No tests to report at this timeImpression: Eye and vision exam normal.Plan: Return to clinic in 12 month(s).Patient Instructions:Patient was given verbal and written instructions regarding eye care following pupil dilation.__________________________________ Dr. An. Ophthalmologist, MDSample Referral Letter Charting Plus™ - Electronic Medical Records 6/6/02Marcus Welby, M.D.1231 8th Street, Suite 222West Des Moines, IA 50265Dear Dr. Welby:John Doe was seen in my office in consultation as requested by you as a new patient for evaluation and care. The following is a summary of my findings and recommendations:Impression: Eye and vision exam normal.Plan: Return to clinic in 12 month(s).If I may be of any further assistance in the care of your patient, please let me know. Thank you for providing me the opportunity to participate in the care of your patients. Sincerely,An. Ophthalmologist, MDSample Prescription Charting Plus™ - Electronic Medical Records Dr. An. Ophthalmologist, MDDEA#:_________________________________________________________Doe6/6/02Date:JName:JohnOD: +0.50 +1.50 X 125 Prism 1.75OS: +6.00 +3.50 X 125 Prism 4.00 BASE IN FresnelAdd: OD: +1.00 OS: +1.00Dr._____________________________________________Sample Billing Statement Charting Plus™ - Electronic Medical RecordsBilling Statement - Thursday, June 06, 2002Provider:An. Ophthalmologist, MDPatient: John J Doe, Chart 1124123 E. Freckle St.Jersey City, NJ 07040Diagnoses1. V72.0 Examination Of Eyes And VisionTreatments1. 99213 Office or other outpatient visit - est. patient - 15 min.Related Diagnoses: V72.0Modifiers:Units:Referring Physician: A. General Practitioner, MDDate Last Seen: 07/26/2001Sample Patient Instructions Charting Plus™ - Electronic Medical Records Patient Instructions for John Doe on 6/6/02YOUR EYES HAVE BEEN DILATEDDilation drops temporarily increase the size of your pupils. This lets us accurately investigate the health of your eyes and other important general health aspects. Dilation of your eyes is a temporary inconvenience; however, benefits far outweigh the inconvenience.The effects of eye dilation drops will gradually decrease. It typically takes TWO to SIX HOURS for the effects to wear off. During this time, reading may be more difficult and sensitivity to light may increase. For a short time, wearing sunglasses may help. Notify us if you feel your long distance vision is blurred excessively before attempting to drive. Your patience during this very important procedure is appreciated!CALL MY OFFICE IMMEDIATELY AT 515-327-8850 IF YOU EXPERIENCE EXCESSIVE PAIN, DISCOMFORT OR NAUSEAREMEMBER TO HAVE REGULAR MEDICAL EYE EXAMINATIONS.Eye disease can occur at any age. Since most blindness is preventable if diagnosed and treated early, it is extremely important to have regular eye examinations. Keep in mind that many eye diseases are asymptomatic until after the damage to the eye has already occurred so early detection is the key. Use this as a reminder to plan for regular eye examinations to maintain sight throughout a lifetime._______________________________An. Ophthalmologist, MDCATARACTWhat is a cataract?* A cataract is the loss of transparency of the lens of the eye. It often appears like a window that is fogged with steam.What causes cataract formation?* Aging, the most common cause.* Family history.* Steroid use.* Injury to the eye.* Diabetes.* Previous eye surgery.* Long-term exposure to sunlight.How do I know if I have a cataract?* The best way for early detection is regular eye examinations by your medical eye doctor. There are many causes of visual loss in addition to the cataract such as problems involving the optic nerve and retina. If these other problems exist, cataract removal may not result in the return or improvement of vision. Your eye doctor can tell you how much improvement in vision is likely.Does it take a long time for a cataract to form?* Cataract development varies greatly between patients and is affected by the cause of the cataract. Generally, cataracts progress gradually over many years. Some people, especially diabetics and younger patients, may find that cataract formation progresses rapidly over a few months making it impossible to know exactly how long it will take for the cataract to develop. What is the treatment for cataracts?* The only way to remove a cataract is surgery. If the symptoms are not restricting your activity, a change of glasses may alleviate the symptoms at this time. No medications, exercise, optical devices or dietary supplements have been shown to stop the progression or prevent cataracts.It is important to provide protection from excessive sunlight. Making sure that the sunglasses you wear screen out ultraviolet (UV) light rays or your regular eyeglasses are coated with a clear, anti-UV coating will help prevent or slow the progression of cataracts.How do I know if I need surgery?* Surgery is considered when your vision is interfering with your daily activities. It is important to evaluate if you can see to do your job and drive safely. Can you read and watch TV in comfort? Are you able to cook, do your shopping and yard work or take your medications without difficulty? Depending on how you feel your vision is affecting your daily life, you and your eye doctor will decide together when it is the appropriate time to do surgery.What is involved with cataract surgery?* This surgery is generally performed under local anesthesia on an outpatient basis. With the assistance of a microscope, the cloudy lens is removed and replaced with a permanent intraocular lens implant.Right after the surgery you should be able to immediately perform all your normal activities except for the most strenuous ones. You will need to take eye drops as directed by your eye doctor. Follow-up visits are necessary to make sure the surgical site is healing without problems.This procedure is performed on over 1.4 million people each year in the United States alone, 95% without complications. With this highly successful procedure, 90% of the time vision improves unless a problem also exists with the cornea, retina or optic nerve. As with any surgery, a good result cannot be guaranteed._______________________________ An. Ophthalmologist, MD。
【惟视·征途】眼科英文篇——视力,你真的可以准确表达吗?
【惟视·征途】眼科英⽂篇——视⼒,你真的可以准确表达吗?在正式开始本期内容之前,先通过以下完整、简洁的病史记录复习前两期的内容,这或许会在您今后的病例报告及⽂章写作中有所价值。
注:点击可查看⼤图⽆论在⼤会现场聆听精彩报告时,亦或在家中默默阅读⽂献时,总有⼀些时刻会让⼩编感到茫然和“蒙圈”,⽐如在某外籍⼤咖分享Case时提到:What?!怎么看着这么眼熟?这应该和Disco舞曲或者某化学药品的PH值没关系!于是,好学的⼩编翻开Kanski(The Bible of Ophthalmology)⼀点⼀点寻找答案。
原来,这个是某患者右眼视⼒的完整表述。
可做以下拆分:Dsc OD 6/30 PH 6/8。
待我⼀⼀道来!1D即Disitance,也就是我们常说的远视⼒,是在20 英尺(Feet)或6.1⽶(Meter)处测得的视⼒;与之相对应的是N,Near即近视⼒,是在30cm⾄40cm处测得的视⼒,常⽤J(Jaeger)表⽰,⼀定不要忘了在给⽼年⼈测近视⼒时带上花镜(Plus power lens, reading glasses)。
2sc是sine correctore的缩写,即裸眼视⼒;与之对应的是cc,cum correctore的缩写,即戴镜视⼒。
3OD代表右眼,这个⼤家都⼗分熟悉,oculus dexter的缩写;OS左眼是oculus sinister的缩写,OU双眼,是oculi uterque的缩写,这些⼤家不需要记,都是拉丁⽂…46/30Snellen视⼒(Snellen acuity),英国通常⽤⽶制(Meter)表述,6/30即表⽰视⼒为6/6(1.0)的⼈在30⽶处看到的视标,受试者仅能在6⽶处看到;美国通常⽤英尺制(Feet),表述为20/100;中国、⽇本则⽤⼩数表述,为0.2。
5PH为Pin hole的缩写,即⼩孔视⼒,通过佩戴⼩孔镜,可粗略矫正屈光不正(Refractive errors,ametropia)。
美国眼科学会弱视临床指南解读(全文)
美国眼科学会弱视临床指南解读(全文)2017年11月,美国眼科学会(American Academy of Ophthalmology,AAO)发布了最新版弱视临床指南(Preferred Practice Pattern,PPP)[1]。
该指南是国际上有关弱视诊治和弱视患者管理的指导性文件,内容涵盖弱视的定义、危险因素、分类、诊断、治疗和护理计划及预后等,新版弱视PPP的发布将在弱视的临床实践中发挥重要作用。
1 弱视PPP制定背景作为对其会员和公众所提供的服务,AAO秉承循证医学的思想,依据临床研究所提供证据的分级标准,编写眼科PPP系列,并根据最新的研究进展定期更新内容。
新版弱视PPP基于美国儿童眼病研究小组(Pediatric Eye Disease Investigator Group,PEDIG)以及其他相关研究的新成果,将近年弱视研究领域的新进展融于指南中,新版指南的内容不仅体现开放性,而且强调了诊疗建议的重点,语言更为严谨规范,其实用性进一步增强。
2 弱视PPP主要内容及解读2.1 弱视的定义和分类弱视多为单眼,很少为双眼发生的最佳矫正视力低下,通常见于眼部无其他器质性病变者。
弱视是一种视觉图像处理异常导致的中枢神经系统发育障碍,极少有累及眼或视路的结构异常,且患者视力低下不能仅归因于结构异常的作用。
弱视眼同时伴有对比敏感度和调节功能异常。
弱视眼的对侧眼并不正常,但其病变都很细微。
弱视分为斜视性弱视、屈光性弱视(包括屈光参差性和双侧高度屈光不正性弱视)、形觉剥夺性弱视(包括屈光介质混浊和上睑下垂所致的弱视)和遮盖性弱视4种类型。
解读:新版弱视PPP在定义中首次强调弱视是中枢神经系统发育异常,继续强调弱视的异常不应只关注视力以及弱视眼,还应关注视功能的其他要素,比如对比敏感度和调节功能,弱视眼的对侧眼并非"好眼"、"正常眼"。
在分类中,新增了遮盖性弱视,这种由于治疗不当所致的弱视临床上并不少见,适当减少遮盖量或压抑药物使用频次可减少遮盖性弱视发生。
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PediatricEye Evaluations I. ScreeningII. ComprehensiveOphthalmic EvaluationPrepared by the American Academy of Ophthalmology Pediatric Ophthalmology/Strabismus Panel Pediatric Ophthalmology/Strabismus Panel MembersLinda M. Christmann, MD, ChairPatrick J. Droste, MDSheryl M. Handler, MD, American Association for Pediatric Ophthalmology and Strabismus RepresentativeRichard A. Saunders, MDR. Grey Weaver, Jr., MDSusannah G. Rowe, MD, MPH, Methodologist Norman Harbaugh, MD, FAAP, American Academy of Pediatrics Representative Donya A. Powers, MD, American Academy of Family Physicians Representative Preferred Practice Patterns Committee MembersSid Mandelbaum, MD, ChairEmily Y. Chew, MDLinda M. Christmann, MDDouglas E. Gaasterland, MDSamuel Masket, MDStephen D. McLeod, MDChristopher J. Rapuano, MDDonald S. Fong, MD, MPH, Methodologist Academy StaffFlora C. Lum, MDNancy Collins, RN, MPHDoris MizuiriMedical Editor: Susan GarrattDesign: Socorro Soberano Reviewed by: CouncilApproved by: Board of TrusteesSeptember 8, 2007 Copyright American Academy of Ophthalmology 2007All rights reserved2nd Printing January 2010AMERICAN ACADEMY OF OPHTHALMOLOGY and PREFERRED PRACTICE PATTERN are registered trademarks of the American Academy of Ophthalmology. All other trademarks are the property of their respective owners.This document should be cited as: American Academy of Ophthalmology Pediatric Ophthalmology/Strabismus Panel. Preferred Practice Pattern®Guidelines. Pediatric Eye Evaluations. San Francisco, CA: American Academy of Ophthalmology; 2007. Available at: /ppp. As a service to its members and the public, the American Academy of Ophthalmology has developed a series of guidelines called Preferred Practice Patterns that identify characteristics and components of quality eye care. The Preferred Practice Pattern® guidelines are based on the best available scientific data as interpreted by panels of knowledgeable health professionals. In some instances, such as when results of carefully conducted clinical trials are available, the data are particularly persuasive and provide clear guidance. In other instances, the panels have to rely on their collective judgment and evaluation of available evidence.Preferred Practice Patterns provide guidance for the pattern of practice, not for the care of a particular individual. While they should generally meet the needs of most patients, they cannot possibly best meet the needs of all patients. Adherence to these Preferred Practice Patterns will not ensure a successful outcome in every situation. These practice patterns should not be deemed inclusive of all proper methods of care or exclusive of other methods of care reasonably directed at obtaining the best results. It may be necessary to approach different patients’ needs in different ways. The physician must make the ultimate judgment about the propriety of the care of a particular patient in light of all of the circumstances presented by that patient. The American Academy of Ophthalmology is available to assist members in resolving ethical dilemmas that arise in the course of ophthalmic practice.The Preferred Practice Pattern®guidelines are not medical standards to be adhered to in all individual situations. The Academy specifically disclaims any and all liability for injury or other damages of any kind, from negligence or otherwise, for any and all claims that may arise out of the use of any recommendations or other information contained herein.References to certain drugs, instruments, and other products are made for illustrative purposes only and are not intended to constitute an endorsement of such. Such material may include information on applications that are not considered community standard, that reflect indications not included in approved FDA labeling, or that are approved for use only in restricted research settings. The FDA has stated that it is the responsibility of the physician to determine the FDA status of each drug or device he or she wishes to use, and to use them with appropriate patient consent in compliance with applicable law.Innovation in medicine is essential to assure the future health of the American public, and the Academy encourages the development of new diagnostic and therapeutic methods that will improve eye care. It is essential to recognize that true medical excellence is achieved only when the patients’ needs are the foremost consideration.All Preferred Practice Patterns are reviewed by their parent panel annually or earlier if developments warrant and updated accordingly. To ensure that all guidelines are current, each is valid for 5 years from the “approved by” date unless superseded by a revision.Financial Disclosures:This author has disclosed the following financial relationships occurring from January 2006 to August 2007:Norman Harbaugh, MD, FAAP: Kids First – Grant support. Kids Time – Equity owner. Medimmune – Lecture fees. Centers for Disease Control, Merck, United Healthcare – Consultant/Advisor.TABLE OF CONTENTSINTRODUCTION (2)SECTION I. SCREENINGORIENTATION (3)Entity (3)Patient Population (3)Activity (3)Intended Users of the Guideline (3)Purpose (3)Goals (3)BACKGROUND (3)Epidemiology of Childhood Ocular Conditions (3)Rationale for Periodic Screenings (4)SCREENING PROCESS (5)History (5)Screening Examination (7)Automated Methods (8)Referral Plan (9)Provider and Setting (10)SECTION II. COMPREHENSIVE OPHTHALMIC EVALUATIONORIENTATION (11)Entity (11)Patient Population (11)Activity (11)Intended Users of the Guideline (11)Purpose (11)Goals (11)BACKGROUND (11)CARE PROCESS (12)History (12)Examination (12)Additional Tests (15)Diagnosis and Management (16)Provider (18)Counseling and Referral (18)APPENDIX 1. SUMMARY OF MAJOR RECOMMENDATIONS FOR CARE (19)APPENDIX 2. VISION SCREENING STATISTICS (21)APPENDIX 3. AMERICAN ACADEMY OF PEDIATRICS “SEE RED CARD” ORDERFORM ................................................. .. (22)APPENDIX 4. LEARNING DISABILITIES, DYSLEXIA, AND VISION: JOINT POLICY STATEMENT...................................... .. (23)SUGGESTED READING AND RESOURCES (33)RELATED ACADEMY MATERIALS (34)REFERENCES (35)INTRODUCTIONThe Preferred Practice Pattern® (PPP) guidelines have been written on the basis of threeprinciples.◆Each Preferred Practice Pattern should be clinically relevant and specific enough to provide usefulinformation to practitioners.◆Each recommendation that is made should be given an explicit rating that shows its importance to thecare process.◆Each recommendation should also be given an explicit rating that shows the strength of evidence thatsupports the recommendation and reflects the best evidence available.In the process of revising this document, a detailed literature search in Medline and the Cochrane Library for articles in the English language was conducted on the subject of pediatric eyeevaluation for the years 2001 to 2006. The results were reviewed by the PediatricOphthalmology/Strabismus Panel and used to prepare the recommendations, which they rated in two ways. The panel first rated each recommendation according to its importance to the careprocess. This “importance to the care process” rating represents care that the panel thought would improve the quality of the patie nt’s care in a meaningful way. The ratings of importance aredivided into three levels.◆Level A, defined as most important◆Level B, defined as moderately important◆Level C, defined as relevant but not criticalThe panel also rated each recommendation on the strength of evidence in the available literature to support the recommendation made. The “ratings of strength of evidence” also are divided intothree levels.◆Level I includes evidence obtained from at least one properly conducted, well-designed randomizedcontrolled trial. It could include meta-analyses of randomized controlled trials.◆Level II includes evidence obtained from the following:♦Well-designed controlled trials without randomization♦Well-designed cohort or case-control analytic studies, preferably from more than one center♦Multiple-time series with or without the intervention◆Level III includes evidence obtained from one of the following:♦Descriptive studies♦Case reports♦Reports of expert committees/organizations (e.g., PPP panel consensus with external peer review) The evidence is that which supports the value of the recommendation as something that should be performed to improve the quality of care. The panel believes that it is important to make available the strength of the evidence underlying the recommendation. In this way, readers can appreciate the degree of importance the committee attached to each recommendation and they can understand what type of evidence supports the recommendation.The ratings of importance and the ratings of strength of evidence are given in bracketedsuperscripts after each recommendation. For instance, “[A:II]” indicates a recommendation with high importance to clinical care [A], supported by sufficiently rigorous published evidence,though not by a randomized controlled trial [II].The sections entitled “Orientation” and “Background” do not include recom mendations; rather, they are designed to educate and provide summary background information and rationale for the recommendations that are presented in the Care Process section. A summary of the majorrecommendations for care is included in Appendix 1.The Pediatric Eye Evaluations PPP has two parts. The first section focuses on pediatric eye and vision screening. It is intended to be used by pediatricians, family practice physicians, physicians, nurses, other health care professionals, and trained lay people involved in screening. The second section is the comprehensive pediatric ophthalmic evaluation. This section is designed to be used by ophthalmologists who perform comprehensive medical eye evaluations for children.S ECTION I.S CREENINGORIENTATIONENTITYChildhood screening examination performed by a pediatrician, family practice physician, otherphysician, nurse, orthoptist, other health care professional, or trained layperson for detection ofeye and vision problems.PATIENT POPULATIONNewborns and children through age 18 years.ACTIVITYPediatric eye and vision screening.INTENDED USERS OF THE GUIDELINEPediatricians, family practice physicians, other physicians, nurses, orthoptists, other health careprofessionals, and trained lay persons.PURPOSETo identify children who may have eye or visual abnormalities, or risk factors for developing eyeor vision problems, and refer them for a comprehensive pediatric ophthalmic evaluation.GOALS◆Describe techniques for periodic eye and vision screening examinations for children,documentation of which includes the following information:1♦Risk factors for eye and visual abnormalities♦Level of vision in each eye individually♦Assessment of ocular alignment♦Assessment for the presence of ocular structural abnormalities◆Communicate screening results and follow-up plan to family/caregiver◆ Refer all children who fail screening (refer to Screening Examination section) or who cannot besuccessfully screened at their second attempt2; physicians or other practitioners providing ongoingcare of the child should verify at the next visit that the recommended comprehensive eyeexamination has taken place◆Educate screening personnelBACKGROUNDEPIDEMIOLOGY OF CHILDHOOD OCULAR CONDITIONSIn newborns and early infancy, structural abnormalities such as congenital cataract, retinopathy ofprematurity, congenital glaucoma, and retinoblastoma (a vision- and life-threatening malignancy),are the most severe vision-threatening eye problems. Other childhood ocular problems includestrabismus, amblyopia, and refractive problems. Table 1 lists prevalence and incidence data forchildhood ocular conditions.Strabismus is any ocular misalignment. The most common types of strabismus are esotropia(inwardly deviating eyes, or crossed eyes) and exotropia (outwardly deviating eyes, or wall-eyes).Amblyopia refers to an abnormality of visual development characterized by decreased best-corrected visual acuity not fully attributable to a structural abnormality of the eye. Amblyopia maybe unilateral or bilateral and is best treated in early childhood. However, recent data show thatamblyopia may be treated even in the teenage years.3 The prevalence of amblyopia varies byrace/ethnicity.Approximately half of amblyopia is secondary to strabismus (mainly esotropia) andthe other half is from other causes such as high refractive errors, anisometropia (asymmetricrefractive errors), or structural ocular problems.4-7 Amblyopia is unusual in children withintermittent exotropia.8 The prevalence of amblyopia in children with developmental delay issixfold greater than in children who were healthy, full-term infants.9,10 Over 6 million Americanshave amblyopia, and it is responsible for loss of vision in more people under the age of 45 than allother causes combined.11TABLE1 C HILDHOOD O CULAR C ONDITIONSCondition FrequencyCongenital cataract 0.06%12 (prevalence)Retinopathy of prematurity 52%13 (incidence in infants <750 g at birth)32%13 (incidence in infants 750-799 g at birth)15%13 (incidence in infants 1000-1250 g at birth)Congenital glaucoma 0.01%14 (prevalence)Retinoblastoma 0.005%15 (incidence in children <15 years)Strabismus 4%16,17 (prevalence)Amblyopia 2% to 3%7,18-22 (prevalence)Refractive errorsMyopia Hyperopia Astigmatism 9%23 (prevalence in children aged 5 to 17 years) 13%23 (prevalence in children aged 5 to 17 years) 28%23 (prevalence in children aged 5 to 17 years)Visually important refractive errors include high hyperopia, moderate astigmatism, moderate to high myopia, and asymmetric refractive errors. An estimated 5% to 7% of preschool children have visually important refractive errors.24 Twenty-five percent of children between the ages of 6 and18 years would benefit from corrective lenses for refractive error or other reasons.25 During theschool years, visual difficulties such as those caused by uncorrected refractive errors may interfere with school performance.Premature birth is a major risk factor for severe visual impairment and blindness in childhood. The most common ocular problem in preterm infants is retinopathy of prematurity (ROP). Thefrequency and severity of ROP is inversely related to gestational age. Preterm infants also have higher rates of amblyopia, strabismus, refractive error, optic atrophy, and cortical visualimpairment. Years later, these children may develop glaucoma and retinal detachments.26,27 The visual impairment is often accompanied by cerebral palsy, epilepsy, and other motor and mental handicaps.27RATIONALE FOR PERIODIC SCREENINGSAmblyopia meets the World Health Organization (WHO) guidelines for a disease that benefits from screening because it is an important health problem for which there is an accepted treatment,a recognizable latent or early symptomatic stage, and a suitable test or examination.28,29 Eye andvision screening is most effective when performed periodically throughout childhood.30-37 Thecombined sensitivity of a series of screening encounters is much higher than that of a singlescreening test, and it is the combined sensitivity that is applicable to the issue of screeningeffectiveness. Anisometropia and small-angle strabismus are the leading causes of undetectedamblyopia. Because a large percentage of children with amblyopia and strabismus go undetected and untreated,38,39 most major authorities agree that extending vision screening to all children is extremely important.1,40,41The purpose of periodic eye and vision screening is to detect pediatric eye disorders, especially amblyopia, at a sufficiently early age to allow effective treatment. The earlier amblyopia isdetected and properly treated, the higher the likelihood of visual acuity recovery.30,42,43 Starting treatment at a young age may also increase the likelihood of compliance and the rate of visionrecovery.44 The Amblyopia Treatment Study demonstrated that more than 75% of amblyopicchildren younger than 7 years can have significant improvement in the amblyopic eye (to 20/30 or better) as the result of treatment (see Amblyopia PPP45).31,46 Based on studies of amblyopiadetected before the age of 6 years but incompletely treated, it appears that the potential for thetreatment of amblyopia persists to approximately age 12 years or older, at which time the plasticity of the visual pathways decreases.3,47 With rare exceptions,48,49 amblyopia results in lifelong visual loss if it is untreated or insufficiently treated in early childhood.A discussion of the statistics on eye and vision screening in children is in Appendix 2.SCREENING PROCESSThe optimal timing and method of pediatric vision screening has not been definitively established and is the subject of ongoing research. Guidelines for pediatric vision screening are evolving as new tests and technologies are introduced and new studies are completed.Eyes can be examined at any age, and a series of age-appropriate screening examinations isrecommended throughout childhood (see section on Screening Examination for the recommended ages for pediatric eye screening). Age-appropriate eye and vision evaluations should be performed in the newborn period and at all subsequent health supervision visits,[A:III] because differentchildhood eye problems may be detected at each visit and new problems can arise duringchildhood. In the newborn and early infancy, the examination concentrates on detection ofstructural anatomical abnormalities. Detection of other abnormalities such as amblyopia andstrabismus are added as the child ages.Children should have their subjective visual acuity assessed using a vision chart.[A:III] Childrenwho fail a screening should be referred for a comprehensive ophthalmic evaluation after the first screening failure.[A:III] Children who fail to complete subjective visual acuity assessment should be considered untestable. Children who are untestable on the first attempt should be referred for a comprehensive ophthalmic evaluation or a repeat screening should be attempted.[A:III] If a child is unable to cooperate for vision testing at 3 years of age, a second attempt should be made within 6 months.[A:III] If the child is 4 years old, a second attempt should be made within the month.1Although the child may be rescreened if screening is inconclusive or unsatisfactory, undue delays should be avoided; if retesting is inconclusive, referral for a comprehensive ophthalmic evaluation is indicated.2[A:III] Children who are untestable on two occasions have been shown to have ahigher incidence of pathology than children who pass screening.2 The Joint Policy Statement of the American Academy of Pediatrics, American Association of Certified Orthoptists, American Association for Pediatric Ophthalmology and Strabismus, and American Academy ofOphthalmology recommends that a repeat screening attempt should be performed within 4 to 6months for a failed screening at age 3 years and within 1 month at age 4 years.1HISTORYAt a child’s first examination by a new primary care provider, a history of risk factors for eye and vision abnormalities should be elicited.[A:III] A detailed family history of eye and visionabnormalities in first-degree family members (mother, father, and siblings) and a history of past and present medical problems should be elicited. Infants detected to be at risk for eye problems because of prematurity, family history of congenital cataract, congenital glaucoma,retinoblastoma, or metabolic or genetic disease should be referred for a comprehensive ophthalmic evaluation as early as possible.[A:III] For children with a family history of congenital or juvenilecataract, the referral is best made while the baby is still in the newborn nursery. A child with afamily history of amblyopia and/or strabismus in a first-degree family member should be referredfor a comprehensive ophthalmic evaluation at age 12 to 24 months or sooner if ophthalmicproblems are noted. Children with a history of medical problems that are risk factors fordevelopment of eye problems should also be referred for a comprehensive ophthalmic evaluation.At each scheduled well-child examination, the primary care provider should ask theparent/caregiver about the baby’s visual interactions and possible eye or vision problems. Table 2lists specific examples of abnormalities or observations that require referral for a comprehensiveophthalmic evaluation.TABLE2 I NDICATIONS FOR R EFERRAL FOR A C OMPREHENSIVE P EDIATRIC O PHTHALMIC E VALUATIONIndication Specific ExamplesRisk factors (general health problems, systemic disease, or use of medications that are known to be associated with eye disease and visual abnormalities) • Prematurity (birthweight less than 1500 grams or gestational age 30 weeks or less) • Retinopathy of prematurity• Intrauterine growth retardation• Perinatal complications (evaluation at birth and at 6 months)• Neurological disorders or neurodevelopmental delay (upon diagnosis)• Juvenile idiopathic arthritis (upon diagnosis)• Thyroid disease• Cleft palate or other craniofacial abnormalities• Diabetes mellitus (5 years after onset)• Systemic syndromes with known ocular manifestations (at 6 months or upon diagnosis)• Chronic systemic corticosteroid therapy or other medications known to cause eye disease• Suspected child abuseA family history of conditions that cause or are associated with eye or vision problems • Retinoblastoma• Childhood cataract• Childhood glaucoma• Retinal dystrophy/degeneration• Strabismus• Amblyopia• Eyeglasses in early childhood• Sickle cell anemia• Systemic syndromes with known ocular manifestations• Any history of childhood blindness not due to trauma in a parent or siblingSigns or symptoms of eye problems by history or observations by family members* • Defective ocular fixation or visual interactions• Abnormal light reflex (including both the corneal light reflections and the red fundus reflection)• Abnormal or irregular pupils• Large and/or cloudy eyes• Drooping eyelid• Lumps or swelling around the eyes• Ocular alignment or movement abnormality• Nystagmus (shaking of eyes)• Persistent tearing, ocular discharge• Persistent or recurrent redness• Persistent light sensitivity• Squinting/eye closure• Persistent head tilt• Learning disabilities or dyslexiaN OTE: These recommendations are based on panel consensus.* Headache is not included since it is rarely caused by eye problems in children. This complaint should first be evaluated by the primary care physician.SCREENING EXAMINATIONThe screening examination should include examination of the red reflex to detect abnormalities ofthe ocular media; external inspection to detect ocular abnormalities; pupil examination; visualacuity on an age-appropriate basis; and, after 6 months of age, the corneal light reflection test(Hirschberg reflex) and cover testing for ocular alignment as well as motility testing.[A:III] Whencooperation and pupil size permit, ophthalmoscopy should be used to view the optic nerve andposterior pole.Table 3 indicates the screening methods to be used at each age and the indications for referral. Theearliest screening takes place at the newborn medical examination and is limited to the red reflex,identification of structural abnormalities, and pupil examination. If a structural eye problem or anabnormal red reflex is detected, the baby should be referred on an urgent basis.[A:III] At 6 months ofage all infants should be evaluated for fixation preference, ocular alignment, and the health ofocular structures.[A:III]TABLE3 R ECOMMENDED A GES AND M ETHODS FOR P EDIATRIC E YE S CREENINGRecommended Age Method Indications for Referral to an OphthalmologistNewborn to 3 months Red reflex Absent, white, dull, opacity, or asymmetricExternal inspection Structural abnormalityPupil examination Irregular shape, unequal size, poor or unequal reaction3 to 6 months (approximately) Fix and follow Failure to fix and follow in a cooperative infantRed reflex Absent, white, dull, opacity, or asymmetricExternal inspection Structural abnormalityPupil examination Irregular shape, unequal size, poor or unequal reaction6 to 12 months and until child is able to cooperate for verbal visual acuity Fix and follow with each eye Failure to fix and followAlternate occlusion Failure to object equally to covering each eye Corneal light reflection Asymmetric or displacedRed reflex Absent, white, dull, opacity, or asymmetricExternal inspection Structural abnormalityPupil examination Irregular shape, unequal size, poor or unequal reaction3 years and4 years (approximately) Visual acuity* (monocular) 20/50 or worse, or 2 lines of difference between the eyes Corneal light reflection/ cover-uncoverAsymmetric/ocular refixation movementsRed reflex Absent, white, dull, opacity, or asymmetricExternal inspection Structural abnormalityPupil examination Irregular shape, unequal size, poor or unequal reaction5 years (approximately) Visual acuity* (monocular) 20/40 or worse, or 2 lines of difference between the eyesAll other tests and referralindications are as in age 3 andage 4 yearsEvery 1 to 2 years after age 5 Visual acuity* (monocular) 20/30 or worse, or 2 lines of difference between the eyesAll other tests and referralindications are as in age 3 andage 4 yearsN OTE: These recommendations are based on panel consensus. Although the child may be retested if screening is inconclusive or unsatisfactory, undue delays should be avoided; if inconclusive on retesting, referral for a comprehensive pediatric ophthalmic evaluation is indicated.2[A:II]* Figures, letters, tumbling E or optotypes, Lea symbols50 (Good-Lite Co., Elgin, IL), vision testing machines.The red reflex is a test used to identify clarity of the ocular media. It is performed by looking at each eye with a direct ophthalmoscope from a distance of about 18 inches. The examiner must then answer three questions:1. Is there a red reflex from each eye?2. Are the red reflexes from each eye symmetrical?3. Is the quality of the red reflex normal for the individual infant (taking into account skintone and race or ethnicity)?If the answer to any of the three questions is no, then the red reflex test is abnormal, and a prompt referral to an ophthalmologist skilled in the treatment of infants and children should be made.[A:III] The See Red Card, a simple visual aid designed to help physicians who perform red reflex testing, can be ordered from the American Academy of Pediatrics (see Appendix 3).The Brückner test, a binocular red reflex test, is superior to the conventional red reflex test,because a skilled examiner will be able to detect not only abnormalities of the red reflex but also will be able to assess alignment and large and/or asymmetric refractive errors.51,52The binocular red reflex test is performed in a dimly lit room with the examiner at a distance of about 30 inches(0.75 meter) from the child.51 The examiner overlaps both pupils simultaneously, creating abinocular red reflex with the largest circular light of a direct ophthalmoscope set to focus on the ocular surface, usually at zero. The examiner then assesses the quality of the redness seen within the child’s pupils. Normally, the red reflex from each eye should be of the same color andbrightness. Abnormalities include asymmetric reflexes when one reflex is duller or a differentcolor, a white reflex, a partially or totally obscured reflex, or crescents present in the reflex.Subjective visual acuity chart testing should be performed for a child at the earliest age that ispractical.[A:III] The standard testing distance is 20 feet (6 meters), but testing at 10 feet (3 meters) is more successful in some children.One study reported that 71% to 75% of children age 3 to 3.5 years were successfully screened with crowded HOTV and Lea symbols visual acuity testing administered by lay screeners.53 The most sophisticated test that a child is capable of performing should be used.[A:III] When possible,screeners should enlist the assistance of parents/caregivers in the testing process by showing them the figures, tumbling E game, or optotypes before the test so they can help their child understand the test. In decreasing order of cognitive difficulty, possible acuity tests include Snellen letters, Snellen numbers, tumbling E or optotypes, HOTV, and Lea symbols.1 Because testing visualacuity with isolated targets (figures or letters) may lead to falsely elevated visual acuities,54crowded optotypes or linear visual acuity (a row of optotypes) should be used when possible.[A:III] The Vision in Preschoolers Study Group reported that a crowded line of Lea symbols were more accurate for detecting reduced visual acuity.55 Most Allen figures tests are not crowded and have been shown to be less accurate than other methods.56 The tumbling E is less frequently usedbecause it has a lower success rate in children compared with picture charts.57When performing visual acuity testing, it is critical to ensure monocular testing. To preventpeeking, the occluded eye should be completely covered. Children should not use their own hand as an occluder. If an occluding paddle or spoon is used, the child should not hold it. The screener should monitor the child for any evidence of looking around the occluder, which could include head turning, peeking, or moving the occluder. Use of an adhesive occluder patch ensuresassessment of monocular visual acuity. Special broadly occluding spectacle frames such as Fun Frames (Good-Lite Co., Elgin, IL) are an option if a child will not allow patching. Visual acuity testing of the second eye should be attempted even when the child will not read the largest line with the first eye.Another adjunctive screening method is stereovision (depth perception) assessment, which can be performed using the Titmus test, the various Randot tests, or other means.AUTOMATED METHODSAutomated methods of conducting pediatric eye screening include photoscreening, autorefraction, and visual evoked potential. These technologies are continuing to undergo extensive study,evaluation, and innovation. Currently, there is insufficient evidence to recommend availableautomated methods to replace standard screening techniques and evaluation.58-61。