Guidelines for Data-Parallel Cycle-Stealing in Networks of Workstations
时间序列 数据清洗和预处理 数据分解 box-cox方法 -回复
时间序列数据清洗和预处理数据分解box-cox方法-回复时间序列数据在许多领域中都被广泛使用,例如金融、天气预报、股票市场等。
然而,这些数据通常会受到各种因素的影响,例如噪声、趋势和周期性。
因此,在对时间序列数据进行分析之前,需要进行数据清洗和预处理,以减少这些影响并提高模型的准确性和可靠性。
一种常用的数据预处理方法是数据分解(data decomposition),它可以将时间序列数据分解成不同的成分,包括趋势、季节性和残差。
其中,趋势表示数据中的长期变化模式,季节性表示周期性模式,残差表示剩余的不可预测的随机变动。
在数据分解过程中,一种常用的方法是使用Box-Cox变换(Box-Cox transformation),它可以对时间序列数据进行幂变换,进而减小数据的偏度和峰度。
Box-Cox变换通过引入一个参数来选择变换类型,使得数据更加适合统计建模。
这种变换方法非常有用,特别是在数据不满足正态分布假设的情况下。
下面将详细介绍时间序列数据清洗和预处理的步骤,并解释Box-Cox变换的原理和应用。
第一步:数据清洗数据清洗是时间序列分析的关键步骤之一,它的目的是处理数据中的异常值、缺失值和噪声。
这可以通过以下几个步骤来完成:1. 异常值处理:识别和处理数据中的异常值,可以使用基于统计方法(例如标准差、箱线图)或基于模型的方法(例如使用插值或回归模型进行异常值估计)来处理异常值。
2. 缺失值处理:填充或删除数据中的缺失值,可以使用插值方法(例如线性插值、样条插值、多重插补)来填充缺失值,或者删除缺失值较少的观测点。
3. 噪声滤除:去除数据中的噪声,可以使用滑动平均法、滤波器(例如Butterworth滤波器)或小波变换来滤除噪声。
第二步:数据预处理数据预处理是为了更好地理解和建模时间序列数据,常见的处理方法包括标准化、平滑和分解。
1. 标准化:对数据进行标准化处理,使得数据的均值为0,方差为1,常用的标准化方法有Z-score标准化和最小-最大标准化。
Guideline_Normothermia
AST Guideline Statement for the Maintenance of Normothermiain the Perioperative PatientIntroductionThe maintenance of normothermia in the perioperative patient is essential during all phases of the surgical procedure. Measures to monitor and maintain body temperature should begin in the preoperative phase and continue into the postoperative phase of the surgical procedure. The monitoring of patient temperature is the responsibility of all surgical team members and not just the anesthesia provider.AST Guideline StatementMaintaining normothermia in the perioperative patient is a collaborative effort between the anesthesia provider, the surgeon, perioperative personnel, and perianesthesia personnel. Maintaining Perioperative NormothermiaPerioperative temperature management is imperative to positive surgical outcomes. The body maintains its temperature between 36°C and 38°C by balancing heat production and heat loss. The thermoregulatory mechanisms in the central nervous system (CNS) control this function. The body loses heat through radiation (from tissues), conduction (contact with cool surfaces), evaporation (respiration), and convection (exposure to the environment). Intraoperative hypothermia is one complication for patients receiving general anesthesia, especially in geriatric and pediatric populations. Under anesthesia, the average adult loses 0.5° to 1.5°C (0.9° to 2.7°F), and the greatest heat loss occurs during the first hour of anesthesia. The maintenance of normothermia during the intraoperative period prevents complications associated with hypothermia.Hyperthermia during the surgical procedure can be caused by dehydration, fever, pre-medication, excessive drapes, and a closed anesthesia breathing circuit. In some instances, the surgical procedure may be delayed to permit fluid administration and a reduction in patient temperature, including discontinuing the use of any warming devices. The patient’s body temperature should be continuously monitored throughout the surgical procedure in order to assess metabolic changes.Risk Factors for Hypothermia∙Large volume of irrigation∙Major blood or fluid loss∙Exposure of a large body cavity∙Patient’s age∙Patient’s physical status and preexisting conditions∙Cold surgical environment∙Length and type of surgical procedure∙Type of anesthesiaComplications Associated with Hypothermia∙Coagulopathy∙Altered metabolism, ie metabolic acidosis∙Wound infections∙Shivering∙Cardiovascular effects∙Surgical bleedingExample Protocol for Preventing Hypothermia in the Surgical Patient1.Limit the amount of skin exposed during all phases of the surgical procedure.Suggestions: Surgical team members coordinate efforts to keep patient covered andwarm during the preoperative and postoperative phases with the use of warm blankets or warming devices.2.Monitor patient’s temperature during all phases of the surgical procedure.Suggestions: This is primarily a role of the anesthesia provider, but the circulating CSTor surgical assistant can provide assistance in monitoring the patient’s temperature bychecking the temperature surface monitor that is placed on the patient’s forehead.e warmed irrigation and infusion fluids/solutions.Suggestions: The CST and surgical assistant should use irrigation fluids obtained fromthe blanket and solution warmer located in the substerile room.e of warmed anesthetic gasesSuggestions: The anesthesia provider is responsible for this function.5.Monitor operating room temperature and humidity closely.Suggestions: The CST and surgical assistant should follow established recommendations for temperature and humidity levels in the operating room, and periodically check andrecord these levels for each operating room.6.Utilize heat-maintenance devices (head coverings, leggings, forced-air warming systems,hypothermia/hyperthermia mattress, reflective blankets/head coverings, radiant heatsources).Suggestions: The CST and surgical assistant should know the proper procedures foroperating warming devices and the safety protocol associated with the use of any type of warming device as established by hospital policy and manufacturer’s recommendations.Competency StatementsCompetency Statement Measurable Criteria1. Surgical technologists and surgical assistants are qualified to identify potential complications, associated with hypothermia and hyperthermia in the perioperative environment, and appropriate interventions for treatment. 1. Educational standards as established by the Core Curriculum for Surgical Technology.12. The subject areas of normothermia, hyperthermia and hypothermia are included in the didactic studies as a student.3. The proper use of thermoregulatory methods and devices is included in the didactic studies as a student.4. Students demonstrate the proper application of thermoregulatory methods during clinical rotation, including the proper use and operation of thermoregulatory devices, and are evaluated by preceptors and instructors.5. CSTs and surgical assistants perform patient care duties by applying thermoregulatory methods and devices in the perioperative setting as practitioners.6. CSTs and surgical assistants identify potential patient complications associated with the use of thermoregulatory methods and devices in the perioperative setting as practitioners, including contributing to the decision-making process of proper interventions to treat hyperthermia and hypothermia.7. CSTs and surgical assistants complete continuing education to remain current in their knowledge of hyperthermia, hypothermia, and maintenance of normothermia for the surgical patient.DefinitionsCore Temperature: A temperature of the interior of the body, ranging from 36.8° to 37.7°C (98° to 100°F)Normothermia: A core temperature range of 36°C to 38°C (96.8°F to 100.4°F) Hypothermia: A core temperature less than 36°C (96.8°F)Hyperthermia: A core temperature greater than 38°C (100.4°F)Unplanned perioperative hypothermia: An unexpected core temperature decrease to less than 36°C (96.8° F) as a result of surgeryReferences1.Core Curriculum for Surgical Technology. 5th ed. Littleton, CO: Association ofSurgical Technologists; 2002.2.DeFazio-Quinn DM, Schick L, eds. PeriAnesthesia Nursing Core Curriculum:Preoperative, Phase I and Phase II PACU Nursing. St Louis, MO: WB Saunders;2004.3.Drain CB. Perianesthesia Nursing: A Critical Care Approach. 4th ed.St Loui,MO: WB Saunders; 2003.4.Meeker M, Rothrock J, eds. Alexander’s Care of the Patient in Surgery. 12th ed.5.St. Louis, MO: CV Mosby; 2003.6.Phillips N. Berry & Kohn’s Operating Room Technique. 10th ed. St Louis, MO:7.2004.8.Price P, Frey K, Junge TL, eds. Surgical Technology for the SurgicalTechnologist: A Positive Care Approach. 2nd ed. Clifton Park, NY: DelmarThomson Learning; 2004.9.Wagner VD. Impact of perioperative temperature management on patient safety.Surgical Services Management, 2003; 9 (4): 38-43.。
guidelines-diabetes-FT
ESC and EASD GuidelinesGuidelines on diabetes,pre-diabetes,and cardiovascular diseases:full text {The T ask Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC)and of the European Association for the Study of Diabetes (EASD)Authors/Task Force Members,Lars Ryde´n,Co-Chairperson (Sweden)*,Eberhard Standl,Co-Chairperson (Germany)*,Małgorzata Bartnik (Poland),Greet Van den Berghe (Belgium),John Betteridge (UK),Menko-Jan de Boer (The Netherlands),Francesco Cosentino (Italy),Bengt Jo¨nsson (Sweden),Markku Laakso (Finland),Klas Malmberg (Sweden),Silvia Priori (Italy),Jan O¨stergren (Sweden),Jaakko Tuomilehto (Finland),Inga Thrainsdottir (Iceland)Other Contributors,Ilse Vanhorebeek (Belgium),Marco Stramba-Badiale (Italy),Peter Lindgren (Sweden)Qing Qiao (Finland)ESC Committee for Practice Guidelines (CPG),Silvia G.Priori,Chairperson (Italy),Jean-Jacques Blanc (France),Andrzej Budaj (Poland),John Camm (UK),Veronica Dean (France),Jaap Deckers (The Netherlands),Kenneth Dickstein(Norway),John Lekakis (Greece),Keith McGregor (France),Marco Metra (Italy),Joa˜o Morais (Portugal),Ady Osterspey (Germany),Juan Tamargo (Spain),Jose´Luis Zamorano (Spain)Document Reviewers,Jaap W.Deckers,CPG Review Coordinator (The Netherlands),Michel Bertrand (France),Bernard Charbonnel (France),Erland Erdmann (Germany),Ele Ferrannini (Italy),Allan Flyvbjerg (Denmark),Helmut Gohlke (Germany),Jose Ramon Gonzalez Juanatey (Spain),Ian Graham (Ireland),Pedro Filipe Monteiro(Portugal),Klaus Parhofer (Germany),Kalevi Pyo¨ra ¨la ¨(Finland),Itamar Raz (Israel),Guntram Schernthaner (Austria),Massimo Volpe (Italy),David Wood (UK)Table of ContentsPreamble ...........................2Introduction..........................2Definition,classification,and screening of diabetes and pre-diabetic glucose abnormalities ............3Epidemiology of diabetes,IGH,and cardiovascular risk.9Identification of subjects at high risk for CVD or diabetes 13Pathophysiology .. (17)Treatment to reduce cardiovascular risk .........24Management of CVD .....................34Heart failure and diabetes .................43Arrhythmias:AF and sudden death ............45Peripheral and cerebrovascular disease ..........48Intensive care.........................52Health economics and diabetes ..............54Appendix ...........................56References .. (57)&2007The European Society of Cardiology and European Association for the Study of Diabetes (EASD).All rights reserved.For Permissions,please e-mail:journals.permissions@*Corresponding authors:Lars Ryde´n,Department of Cardiology,Karolinska University Hospital,Solna SE-171,76Stockholm,Sweden.Tel:þ46851772171;fax:þ468311044;Eberhard Standl Department of Endocrinology,Munich Schwabing Hospital,D-80804Munich,Germany.Tel:þ498930682523;fax:þ498930683906.E-mail address :lars.ryden@ki.se;eberhard.standl@lrz.uni-muenchen.deThe CME Text ‘Guidelines on Diabetes,pre-diabetes and cardiovascular diseases’is accredited by the European Board for Accreditation in Cardiology (EBAC)for ‘2’hours of External CME credits.Each participant should claim only those hours of credit that have actually been spent in the educational activity.EBAC works according to the quality standards of the European Accreditation Council for Continuing Medical Education (EACCME),which is an institution of the Euro-pean Union of Medical Specialists (UEMS).Incompliance with EBAC/EACCME guidelines,all authors participating in this programme have disclosed potential con-flicts of interest that might cause a bias in the article.The Organizing Committee is responsible for ensuring that all potential conflicts of interest relevant to the programme are declared to the participants prior to the CME activities.‡This is the full text version of Eur Heart J doi:10.1093/eurheartj/ehl260.European Heart Journaldoi:10.1093/eurheartj/ehl261The content of these European Society of Cardiology (ESC)Guidelines has been published for personal and educational use only.No commercial use is authorized.No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC.Permission can be obtained upon submission of a written request to Oxford University Press,the publisher of the European Heart Journal and the party authorized to handle such permissions on behalf of the ESC.Disclaimer.The ESC Guidelines represent the views of the ESC and were arrived at after careful consideration of the available evidence at the time they were written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not,however ,override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patients,in consultation with that patient,and where appropriate and necessary the patient’s guardian or carer.It is also the health professional’s responsibility to verify the rules and regulations applicable to drugs and devices at the time of prescription.PreambleGuidelines and Expert Consensus documents aim to present management and recommendations based on all of the rel-evant evidence on a particular subject in order to help phys-icians to select the best possible management strategies for the individual patient,suffering from a specific condition, taking into account not only the impact on outcome,but also the risk–benefit ratio of a particular diagnostic or thera-peutic procedure.Numerous studies have demonstrated that patient outcomes improve when evidence-based guide-line recommendations are applied in clinical practice.A great number of Guidelines and Expert Consensus Documents have been issued in recent years by the European Society of Cardiology(ESC)and also by other organ-izations or related societies.The profusion of documents can question the authority and credibility of guidelines,particu-larly if discrepancies appear between different documents on the same issue leading to confusion for practising phys-icians.In order to avoid these pitfalls,the ESC and other organizations have issued recommendations for formulating and issuing Guidelines and Expert Consensus Documents. The ESC recommendations for guidelines production can be found on the ESC website.It is beyond the scope of this pre-amble to recall all,but the basic rules.In brief,the ESC appoints experts in thefield to carry out a comprehensive review of the literature,with a view to making a critical evaluation of the use of diagnostic and therapeutic procedures,and assessing the risk–benefit ratio of the therapies recommended for management and/or pre-vention of a given condition.Estimates of expected health outcomes are included,where data exists.The strength of evidence for or against particular procedures or treatments is weighed,according to predefined scales for grading rec-ommendations and levels of evidence,as outlined below. The Task Force members of the writing panels,as well as the document reviewers,are asked to provide disclosure statements of all relationships they may have,which might be perceived as real or potential conflicts of interest. These disclosure forms are kept onfile at the European Heart House,headquarters of the ESC and can be made available by written request to the ESC President.Any changes in conflict of interest that arise during the writing period must be notified to the ESC.Guidelines and recommendations are presented in formats that are easy to interpret.They should help physicians to make clinical decisions in their daily routine practice,by describing the range of generally acceptable approaches to diagnosis and treatment.However,the ultimate judgement regarding the care of an individual patient must be made by the physician-in-charge of his/her care.The ESC Committee for Practice Guidelines(CPG)super-vises and coordinates the preparation of new Guidelines and Expert Consensus Documents produced by Task Forces, expert groups or consensus panels.The Committee is also responsible for the endorsement of these Guidelines and Expert Consensus Documents or statements.Once the document has beenfinalized and approved by all the experts involved in the Task Force,it is submitted to outside specialists for review.In some cases,the document can be presented to a panel of key opinion leaders in Europe on the relevant condition,for discussion and critical review. If necessary,the document is revised once more andfinally approved by the CPG and selected members of the Board of the ESC and subsequently published.After publication,dissemination of the message is of para-mount importance.Publication of executive summaries and the production of pocket-sized and PDA-downloadable versions of the recommendations are helpful.However, surveys have shown that the intended end-users are often not aware of the existence of guidelines,or simply do not put them into practice.Implementation programmes are thus necessary and form an important component of the dissemination of knowledge.Meetings are organized by the ESC,and directed towards its member National Societies and key opinion leaders in Europe.Implementation meetings can also be undertaken at a national level,once the guide-lines have been endorsed by the ESC member societies,and translated into the local language,when necessary.All in all,the task of writing Guidelines or Expert Consensus Documents covers not only the integration of the most recent research,but also the creation of educational tools,and implementation programmes for the recommendations.The loop between clinical research,writing of guidelines,and implementing them into clinical practice can then only be completed if surveys and registries are organized to verify that actual clinical practice is in keeping with what is recom-mended in the guidelines.Such surveys and registries also make it possible to check the impact of strict implementation of the guidelines on patient outcome.Classes of Recommendations:Levels of Evidence:IntroductionDiabetes and cardiovascular diseases(CVD)often appear as the two sides of a coin:on one side,diabetes mellitus(DM) has been rated as an equivalent of coronary heart disease (CHD),and conversely,many patients with established CHD Class I Evidence and/or general agreement that a givendiagnostic procedure/treatment is beneficial,useful,and effectiveClass II Conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of the treatment orprocedureClass IIa Weight of evidence/opinion is in favour of usefulness/ efficacyClass IIb Usefulness/efficacy is less well established byevidence/opinionClass III Evidence or general agreement that the treatment or procedure is not useful/effective and in some casesmay be harmfulLevel of Evidence A Data derived from multiple randomizedclinical trials or meta-analysesLevel of Evidence B Data derived from a singlerandomized clinical trial or largenon-randomized studiesLevel of Evidence C Consensus of opinion of theexperts and/or small studies,retrospective studies,registries Recommendations for ESC Guidelines Production at .Page2of72ESC and EASD Guidelinessuffer from diabetes or its pre-states.Thus,it is high time that diabetologists and cardiologists join forces together to improve the quality management in diagnosis and care for the millions of patients who have both cardiovascular and metabolic diseases in common in one and the same person. The cardio-diabetologic approach not only is of utmost import-ance for the sake of those patients,but also instrumental for further progress in thefields of cardiology and diabetology. The European Society of Cardiology(ESC)and the European Association for the Study of Diabetes(EASD)have accepted this challenge and decided to develop joint,evidence-based guide-lines for‘Diabetes and Cardiovascular Diseases’.Experts from both sides were asked to form a T ask Force and to write state-of-the-art chapters.Although individual authors have been assigned to draft the manuscripts according to their specific area of expertise,the guidelines were then extracted and harmonized as a true team effort by the whole group.Hence,the names of all authors appear only on the cover of these guidelines as members of the writing group.Some of the members of the T ask Force were helped in the literature search and writing process by members of their respective teams and these contributors are also named on the cover as contributors.The guidelines were then reviewed by indepen-dent referees appointed by the two scientific organizations whose identity were disclosed,once all criticisms and sugges-tions had been incorporated into the text to achieve the broad-est possible expertise and consensus.The referees are also acknowledged with their names on the cover and are an important,integral part of this scientific guideline exercise. It may seem that these guidelines are rather extensive.They were,however,written for two‘worlds’,diabetology and cardiology.Thus,information that may seem obvious,including pathophysiology,for one part may need a more extensive description for the other.A decision was therefore taken,to keep the main document as complete as possible,making an executive summary and pocket guidelines for those,who are searching short,practical information.These guidelines do not aim to provide detailed information on daily blood glucose management in patients because therapies are tailored to individual patient requirements,particularly in patients with type2diabetes.Achieving the agreed glucose level targets is more important than the therapy and regimen.For those requiring additional information on blood glucose man-agement the Global Guideline for T ype2Diabetes of the Inter-national Diabetes Federation()is recommended. The core approach of the group is depicted in Figure1.An algorithm has been developed to help discover the alternate CVD in patients with diabetes,and vice versa,the metabolic diseases in patients with CHD,setting the basis for appropri-ate joint therapy.This algorithm has also been endorsed by the expert working group of the Declaration of Vienna on February15,2006under the auspices of the Austrian Presidency of the European Union.The purpose of these guidelines is to improve the management of:(1)Patients with overt diabetes.(2)Patients at risk of developing diabetes,as demonstratedby impaired glucose tolerance.(3)Cardiovascular diseases in these patient populations. The terms‘primary prevention’and‘secondary prevention’may not be quite appropriate in the case of diabetes,a high-risk situation in itself,but the terms are strongly conso-lidated and kept in this context when reasonable.It is a great privilege for the two co-chairmen of this task force of having been able to work with thefinest and best reputed experts and scientists in thefield at the European level and to give these guidelines now to the community of cardiologists and diabetologists.On this occasion,we wish to thank all members of the task force who so gene-rously shared their knowledge,as well as the referees for their tremendous input.Special thanks go to Professor Carl Erik Mogensen for his advice on the diabetic renal disease and microalbuminuria sections.We would also like to thank the ESC and the EASD for making these guidelines possible.Finally,we want to express our appreciation of the guideline team at the Heart House,especially Veronica Dean,for their extremely helpful support.Stockholm and Munich,September2006Professor Lars Ryden,Past-President ESCProfessor Eberhard Standl,Vice-President EASDDefinition,classification,and screening of diabetes and pre-diabetic glucose abnormalitiesTable ofRecommendations:Recommendation Class a Level b The definition and diagnosticclassification of diabetes and itspre-states should be based onthe level of the subsequent riskof cardiovascular complicationsI BEarly stages of hyperglycaemiaand asymptomatic type2diabetes arebest diagnosed by an oral glucosetolerance test(OGTT)that givesboth fasting and two-hour post-loadglucose valuesI BPrimary screening for thepotential type2diabetes can bedone most efficiently using anon-invasive risk score,combined with a diagnostic oralglucose tolerance testing inpeople with high score valuesI Aa Class of recommendation.b Level of evidence.ESC and EASD Guidelines Page3of72IntroductionDM is a metabolic disorder of multiple aetiology character-ized by chronic hyperglycaemia with disturbances of carbo-hydrate,fat,and protein metabolism resulting from defects of insulin secretion,insulin action,or a combination of both.1In type1diabetes,it is due to a virtually complete lack of endogenous pancreatic insulin production,whereas in type2diabetes,the rising blood glucose results from a combination of genetic predisposition,unhealthy diet,phys-ical inactivity,and increasing weight with a central distri-bution resulting in complex pathophysiological processes. Traditionally,diagnosis of diabetes was based on symptoms due to hyperglycaemia,but during the last decades much emphasis has been placed on the need to identify diabetes and other forms of glucose abnormalities in asymptomatic subjects.DM is associated with development of specific long-term organ damage(diabetes complications)including retinopathy with potential blindness,nephropathy with a risk of progression to renal failure,neuropathy with risk for foot ulcers,amputation,and Charcot joints and auto-nomic dysfunction such as sexual impairment.Patients with diabetes are at a particularly high risk for cardiovascu-lar,cerebrovascular,and peripheral artery disease.Definition and classification of diabetesSince thefirst unified classification of diabetes by the National Diabetes Data Group in19792and the World Health Organisation(WHO)in1980,3a few modifications have been introduced by the WHO4,5and the American Diabetes Association(ADA),6,7(Table1).Impaired glucose tolerance(IGT)can be recognized by the results of OGTT only:2-h post-load plasma glucose(2hPG) !7.8and,11.1mmol/L(!140and,200mg/dL).A standardized OGTT test performed in the morning,after an overnight fast(8–14h);one blood sample should be taken before and one120min after intake of75g glucose dissolved in250–300mL water in a course of5min(note: timing of the test is from the beginning of the drink). Classification of diabetes includes both aetiological types and different clinical stages of hyperglycaemia as suggested by Kuzuya and Matsuda.8Four main aetiological categories of diabetes have been identified as diabetes type1,type2, other specific types,and gestational diabetes,as detailed in the WHO document4(Tables2and3,Figure2).Type1diabetes characterized by deficiency of insulin due to destructive lesions of pancreatic b-cells;usually pro-gresses to the stage of absolute insulin deficiency. Typically,it occurs in young subjects with acute-onset with typical symptoms of diabetes together with weight loss and propensity to ketosis,but type1diabetes may occur at any age,9sometimes with slow progression.People who have antibodies to pancreatic b-cells such as glutamic-acid-decarboxylase(GAD),are likely to develop either typical acute-onset or slow-progressive insulin-dependent diabetes.10,11Today antibodies to pancreatic b-cells are considered as a marker of type1diabetes, although such antibodies are not detectable in all patients. Type2diabetes is caused by a combination of decreased insulin secretion and decreased insulin sensitivity. Typically,the early stage of type2diabetes is characterized by insulin resistance and decreased ability for insulin secretion causing excessive post-prandial hyperglycaemia. This is followed by a gradually deterioratingfirst-phase insulin response to increased blood glucose concen-trations.12Type2diabetes,comprising over90%of adults with diabetes,typically develops after middle age.The patients are often obese or have been obese in the past and have typically been physically inactive.Ketoacidosis is uncommon,but may occur in the presence of severe infec-tion or severe stress.Gestational diabetes constitutes any glucose perturbation that develops during pregnancy and disappears after deliv-ery.Long-term follow-up studies,recently reviewed by Kim et al.,13reveal that most,but not all,women with gestational diabetes do progress to diabetes after preg-nancy.Long-term studies that have been conducted over a period of more than10years reveal a stable long-term risk of 70%.13In some cases,type1diabetes may be detected during pregnancy.Other types include:(i)diabetes related to specific single genetic mutations that may lead to rare forms of diabetes, as for instance MODY;(ii)diabetes secondary to other patho-logical conditions or diseases(as a result of pancreatitis, trauma,or surgery of pancreas);(iii)drug or chemically induced diabetes.The clinical classification also comprises different stages of hyperglycaemia,reflecting the natural history of absolute or relative insulin deficiency progressing from normoglycae-mia to diabetes.It is not uncommon that a non-diabeticTable1Criteria used for glucometabolic classification according to the WHO(1999),ADA(1997)and(2003)Glucometabolic category Source Classification criteria mmol/L(mg/dL)Normal glucose regulation(NGR)WHO FPG,6.1(110)þ2-h PG,7.8(140)ADA(1997)FPG,6.1(110)ADA(2003)FPG,5.6(100)Impaired fasting glucose WHO FPG!6.1(110)and,7.0(126)þ2-h PG,7.8(140)ADA(1997)FPG!6.1(110)and,7.0(126)ADA(2003)FPG!5.6(100)and,7.0(126)Impaired glucose tolerance(IGT)WHO FPG,7.0(126)þ2-h PG!7.8and,11.1(200)Impaired glucose homeostasis(IGH)WHO IFG or IGTDiabetes mellitus(DM)WHO FPG!7.0(126)or2-h PG!11.1(200)ADA(1997)FPG!7.0(126)ADA(2003)FPG!7.0(126)Values are expressed as venous plasma glucose.FPG¼fasting plasma glucose;2-h PG¼two-hour post-load plasma glucose(1mmol/L¼18mg/dL).Page4of72ESC and EASD Guidelinesindividual may move from one category to another in either ually,a progression towards a more severe glucose abnormality takes place with increasing age.This is reflected by the increase in the2-hPG level with age.14 The currently valid clinical classification criteria have been issued by WHO4and ADA.7These are currently under review by WHO and updated criteria will be introduced soon.The WHO recommendations for glucometabolic classification are based on measuring both fasting and 2-hPG concentrations and recommend that a standardized 75g OGTT should be performed in the absence of overt hyperglycaemia.4The thresholds for diabetes on fasting and2-hPG values were primarily determined by the values where the prevalence of diabetic retinopathy,which is a specific complication of hyperglycaemia,starts to increase. Even though macrovascular diseases such as CHD and stroke are major causes of death in type2diabetic patients and people with IGT,macrovascular disease has not been con-sidered in the classification.This sounds illogical and may give an impression that macrovascular diseases are less important than microvascular consequences of diabetes.Classification according to the ADA criteria strongly encourages the single use of fasting glycaemia only without an OGTT.6,7The currently recommended categories of glucose metab-olism according to WHO and the ADA are presented in Table1(for adults).The National Diabetes Data Group2 and WHO3coined the term IGT,an intermediate category between normal glucose tolerance and diabetes.The ADA6 and the WHO Consultation4proposed some changes to the diagnostic criteria for diabetes and introduced a new category called impaired fasting glucose/glycaemia(IFG). The ADA recently decreased the lower threshold for IFG from6.1to5.6mmol/L,7but this has been criticized and has not yet been adopted by the WHO expert group that recommends to keep the previous cut-points as shown in the WHO consultation report in1999.These criteria were reviewed by a new WHO expert group in2005.In order to standardize glucose determinations,plasma has been recommended as the primary specimen.Since many equipment use either whole blood or venous or capil-lary blood,thresholds for these vehicles have also been given.The non-plasma recommendations for threshold are based on approximate estimates rather than on validated conversion factors.A recent analysis based on the direct pair-wise comparison of various types of specimens suggest that the factors presented in Table4should be used to convert values measured in whole blood,capillary blood, and serum to plasma,respectively.15The glucometabolic category in which an individual is placed depends on whether only fasting plasma glucose (FPG)is measured or if it is combined with a2-hPG value. For example,an individual falling into the IFG category in the fasting state may have IGT or diabetes disclosed by a post-load glucose.The metabolic determinants and physiological bases of FPG and2-hPG differ to some extent.1,16,17This means the categorization of an individual on a FPG value may differ from that based on a2-hPG.Having a normal FPG requires the ability to maintain an adequate basal insulin secretion and an appropriate hepatic insulin sensitivity to controlTable2Aetiological classification of glycaemia disorders a Type1(b-cell destruction,usually leading to absolute insulin deficiency)AutoimmuneIdiopathicType2(may range from predominantly insulin resistance with relative insulin deficiency to a predominantly secretory defect with or without insulin resistance)Other specific types(see Table3)Genetic defects of b-cell functionGenetic defects in insulin actionDiseases of the exocrine pancreasEndocrinopathiesDrug-or chemical-inducedInfectionsUncommon forms of immune-mediated diabetesOther genetic syndromes sometimes associated with diabetes,e.g.:Down’s syndrome,Friedreich’s ataxia,Klinefelter’ssyndrome,Wolfram’s syndromeGestational diabetes ba As additional subtypes are discovered,it is anticipated that they will be reclassified within their own specific category.b Includes the former categories of gestational IGT and gestational diabetes.Table3Other specific types of diabetesGenetic defects of b-cell functionGenetic defects in insulin actione.g.Lipoatrophic diabetesDiseases of the exocrine pancrease.g.Pancreatitis,Trauma/pancreatectomy,Neoplasia,CysticfibrosisEndocrinopathiese.g.Cushing’s syndrome,Acromegaly,Phaeochromocytoma,HyperthyroidismDrug-or chemical-inducede.g.cortisone,anti-depressant drugs,BBs,thiazide Infectionse.g.CytomegalovirusUncommon forms of immune-mediateddiabetes Figure2Disorders of glycaemia:aetiological types and clinical stages(see also Table3).ESC and EASD Guidelines Page5of72hepatic glucose output.Abnormalities of these functions characterize IFG.During an OGTT,the normal response to the absorption of the glucose load is both to suppress hepatic glucose output and to enhance hepatic and skeletal muscle glucose uptake.To keep a post-load glucose level within the normal range requires appropriate dynamics of the b-cell secretory response,amount and timing,in combi-nation with adequate hepatic and muscular insulin sensitivity.RecommendationThe definition and diagnostic classification of diabetes and its pre-states should be based on the level of the subsequent risk of cardiovascular complications.Class I,Level of Evidence B.Glycated haemoglobinGlycated haemoglobin(HbA1c),a useful measure of meta-bolic control and the efficacy of glucose-lowering treat-ment,is an integrated summary of circadian blood glucose during the preceding6–8weeks,equivalent to the lifespan of erythrocytes.18It provides a mean value but does not reveal any information on the extent and frequency of blood glucose excursions.HbA1c has never been rec-ommended as a diagnostic test for diabetes.4,7A primary reason is the lack of a standardized analytical method and therefore lack of a uniform,non-diabetic reference level between various laboratories.A high HbA1c may only ident-ify a fraction of asymptomatic people with diabetes.HbA1c is insensitive in the low range and a normal HbA1c cannot exclude the presence of diabetes or IGT.Markers of glucometabolic perturbationsAn inherent difficulty in the diagnosis of diabetes is the present lack of an identified,unique biological marker that would separate people with IFG,IGT,or diabetes from people with normal glucose metabolism.The use of diabetic retinopathy has been discussed,but the obvious limitation is that this condition in a majority of the patients only becomes evident after several years of hyperglycaemic exposure.1,5–10On the other hand,diabetic retinopathy is diagnosed in 1%of the non-diabetic population.Thus far, total mortality and CVD have not been considered for defin-ing those glucose categories that carry a significant risk. Nevertheless,the vast majority of people with diabetes die from CVD and asymptomatic glucometabolic pertur-bations more than double mortality and the risk for myocar-dial infarction(MI)and stroke.Since the majority of type2 diabetic patients develop CVD,which is a more severe (often even fatal)and costly complication of diabetes than retinopathy,CVD should be considered when defining cut-points for glucose.Comparisons between FPG and2-hPGThe diagnostic levels of FPG and2-hPG are largely based on their association with the risk of having or to develop retino-pathy.As outlined in the1997report by the ADA,6the inci-dence of retinopathy increases already above a FPG of !7.0mmol/L,and not above the higher threshold level of 7.8mmol/L as previously used for the diagnosis of diabetes. The DECODE Study(Figure3)has shown that any mortality risk in people with elevated FPG is actually related to a con-comitantly elevated2-hPG glucose.15,19,20Thus,the current cut-off point for diabetes based on a2-hPG!11.1mmol/L may be too high.Lowering the threshold,although not yet formally challenged.It has been noted that,although an FPG!7.0mmol/L and a2-hPG of!11.1mmol/L sometimes identifies the same individuals,often they may not coincide.In the DECODE Study,21recruiting patients with diabetes by either criterion alone or by their combination,only28%met both,and40% met the fasting and31%the2-hPG criterion only (Figure4).Among those who met the2-hPG criterion,52% did not meet the fasting criterion,and59%of those who met the fasting criterion did not meet the2-hPG criterion. In the U.S.NHANES III Study of previously undiagnosed dia-betic adults aged40–74years,44%met both the FPG and the2-hPG criteria,whereas14%met the FPG criterion only and41%the2-hPG criterion only.22Screening for undiagnosed diabetesRecent estimates suggest that195million people throughout the world have diabetes and that this number will increase to330,maybe even to500million,by2030.23,24Many patients,up to50%in most investigations,with type2dia-betes are undiagnosed21,22,34since they remain asympto-matic and therefore are undetected for many years. Detecting people with undiagnosed type2diabetes is important for both public health and every day clinical prac-tice.Mass screening for asymptomatic diabetes has not been recommended in the general population pending evidence that the prognosis of such patients will improve by early detection and treatment.25,26Importantly,lack of evidence relates to lack of studies testing the hypothesis that early screening would indeed be advantageous.One such study (ADDITION)is ongoing in Denmark,the Netherlands,and the UK.Indirect evidence suggests that screening might be beneficial as it improves the possibility of early detection of diabetes and thereby improved prevention of cardio-vascular complications.In addition,there is an increasing interest in identifying people with IGT,who might benefit from life style or pharmacological intervention to reduce or delay the progression to diabetes.27Extensive data from epidemiological studies have chal-lenged the practice not to utilize the2-hPG showing that a substantial number of people,who do not meet the FPG cri-teria for abnormal glucose tolerance,will satisfy the criteria when exposed to an OGTT.14,21,22,28Thus,the risk of a false negative diagnosis is substantial when measuring FPG alone. The argument for FPG over2-hPG is primarily related to the matter of feasibility.An OGTT has been considered a lessTable4Conversion factors between plasma and other vehiclesfor glucose valuesPlasma glucose(mmol/L)¼0.558þ1.119Âwhole blood glucose(mmol/L)Plasma glucose(mmol/L)¼0.102þ1.066Âcapillary bloodglucose(mmol/L)Plasma glucose(mmol/L)¼20.137þ1.047Âserum glucose(mmol/L)Page6of72ESC and EASD Guidelines。
RECSIT1.1中英文对照全文
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)新版实体瘤疗效评价标准:修订的RECIST指南(1.1版本)Abstract摘要Background背景介绍Assessment of the change in tumour burden is an important feature of the clinical evaluation of cancer therapeutics: both tumour shrinkage (objective response) and disease progression are useful endpoints in clinical trials. Since RECIST was published in 2000, many investigators, cooperative groups, industry and government authorities have adopted these criteria in the assessment of treatment outcomes. However, a number of questions and issues have arisen which have led to the development of a revised RECIST guideline (version 1.1). Evidence for changes, summarised in separate papers in this special issue, has come from assessment of a large data warehouse (>6500 patients), simulation studies and literature reviews.临床上评价肿瘤治疗效果最重要的一点就是对肿瘤负荷变化的评估:瘤体皱缩(目标疗效)和病情恶化在临床试验中都是有意义的判断终点。
acmg指南中英文对照
acmg指南中英文对照English:The ACMG guidelines serve as a comprehensive, evidence-based framework for the interpretation and reporting of genetic variants in clinical practice. They embody rigorous, multidimensional standards to ensure accurate diagnosis, risk assessment, and informed medical decision-making.1. **Classification System:** The guidelines establish a standardized classification system for variants, categorizing them into five distinct classes (pathogenic, likely pathogenic, uncertain significance, likely benign, and benign), based on specific criteria such as population frequency, functional studies, computational predictions, and co-segregation data. This systematic approach promotes consistency and reliability in variant interpretation across laboratories and healthcare providers.2. **Clinical Utility:** ACMG guidelines emphasize the importance of assessing variant clinical utility, considering the potential impact on disease prevention,diagnosis, treatment, or prognosis. This focus ensures that reported findings have clear relevance to patient care, guiding appropriate interventions and management strategies.3. **Ethical Considerations:** Recognizing the ethical complexities surrounding genetic testing, the guidelines address issues such as informed consent, privacy, and return of results. They advocate for transparent communication with patients regarding the implications, limitations, and potential emotional consequences of genetic information, fostering autonomy and trust in the healthcare relationship.4. **Interdisciplinary Collaboration:** The guidelines stress the necessity of interdisciplinary collaboration involving clinicians, genetic counselors, laboratory scientists, and bioinformaticians. Such teamwork ensures comprehensive evaluation of genetic data, effective translation of complex findings into clinically meaningful information, and optimal patient care.5. **Continuous Updating:** Reflecting the rapidly evolving field of genetics, the ACMG guidelines undergo regular review and updating to incorporate new scientificdiscoveries, technological advancements, and emerging best practices. This commitment to staying current ensures that the guidelines remain at the forefront of precision medicine, providing clinicians with the most up-to-date guidance for genetic testing and interpretation.In summary, the ACMG guidelines represent a multifaceted, high-quality standard in genetic testing and interpretation. They encompass a rigorous classification system, prioritize clinical utility, address ethical considerations, promote interdisciplinary collaboration, and embrace continuous updating – all crucial elements that collectively contribute to accurate diagnoses, informed decision-making, and improved patient outcomes in the realm of medical genetics.Chinese:ACMG 指南作为临床实践中遗传变异解读和报告的综合性、循证框架,体现了确保精准诊断、风险评估及明智医疗决策的严格、多维度标准。
胆囊癌临床诊疗的新进展
胆囊癌临床诊疗的新进展中华外科杂志普外空间 2022-08-10 10:00 发表于北京作者:杨自逸,刘诗蕾,蔡晨,吴自友,熊逸晨,李茂岚,吴向嵩,全志伟,龚伟文章来源:中华外科杂志, 2022, 60(8)摘要胆囊癌的恶性程度极高,尚缺乏早期诊断方法和有效治疗手段,亟需高质量研究突破诊疗瓶颈。
本文回顾了2021年国内外发表的胆囊癌研究相关文献,对临床诊疗领域的重要进展进行综述,详细介绍了胆囊癌最新流行病学数据及危险因素、新兴的外周血实验室检查和影像学诊断方法、病理学类型新分类、外科治疗的热点与争议及系统性综合治疗动态。
这些研究结果有助于探索更有效的胆囊癌诊治方法,为改善胆囊癌患者的预后带来希望。
胆囊癌是胆道系统常见的恶性肿瘤,具有症状隐匿、发展迅速、早期转移、预后极差的特点。
我国是胆囊癌的高发地区之一,近年来发病率和病死率呈缓慢上升趋势。
目前仍缺乏特异度和灵敏度均较好的胆囊癌早期诊断手段,临床发现的胆囊癌多为中晚期。
尽管医学科技不断发展,早期诊断和根治性手术切除仍是可能治愈胆囊癌的手段,行之有效的系统性治疗方法依然在不断探索中。
本文展示了2021年胆囊癌临床诊疗领域的研究进展,以探索更好的胆囊癌诊疗方法。
一、流行病学特征(一)发病率与死亡率2020年全球癌症统计数据显示,全球胆囊癌新发115 949例(男性41 062例,女性74 887例),死亡84 695例(男性30 265例,女性54 430例)[1],均居消化系统肿瘤第6位。
胆囊癌全球发病率存在明显的地域差异,全球年龄标准化发病率平均为2.3/10万人,以东亚、南美最高,西欧、北美则发病率较低[2];且近年来男性和年轻群体的胆囊癌发病率呈升高趋势。
我国国家癌症中心数据显示,国内胆囊癌发病率为3.95/10万人(男性3.70/10万人,女性4.21/10万人),死亡率为2.95/10万人(男性1.9/10万人,女性2.1/10万人)[3]。
MIQE Guidelines
/pcr
AMPLIFICATION
Nucleic Acid Extraction (核酸提 取)
/pcr
RNA 纯度和完整性
AMPLIFICATION
Experion Virtual Gel
L C 3’ 5’ 10’ 15’ 1h 2h 4h
Primer B
Forward Primer
Reverse Primer A
1
110
/pcr
Amplicon Secondary Structures
AMPLIFICATION
/mfold/applications
编辑们犯难了“定量PCR数据可信吗?”
/pcr
What are the MIQE guidelines?
AMPLIFICATION
qPCR的国际标准:就评价qPCR实验和发表文章时所必需的实验 信息提出了最低限度的标准。
/pcr
MIQE 指南好处
AMPLIFICATION
/pcr
Reverse Transcription 反转录
AMPLIFICATION
/pcr
Reverse Transcription
AMPLIFICATION
RNA
cDNA
Reality Ideal ?
Reproducible Data Not Reproducible
/pcr
qPCR Target Information
AMPLIFICATION
/pcr
序列同源性分析(BLAST)
AMPLIFICATION
http://www.ncbi.nlm.nih. gov/BLAST/Blast.cgi
SAE J2012-2007-诊断故障代码定义
__________________________________________________________________________________________________________________________________________ SAE Technical Standards Board Rules provide that: “This report is published by SAE to advance the state of technical and engineering sciences. The use of this report is entirely voluntary, and its applicability and suitability for any particular use, including any patent infringement arising therefrom, is the sole responsibility of the user.” SAE reviews each technical report at least every five years at which time it may be reaffirmed, revised, or cancelled. SAE invites your written comments and suggestions. Copyright © 2007 SAE InternationalAll rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of SAE. TO PLACE A DOCUMENT ORDER: Tel: 877-606-7323 (inside USA and Canada) Tel: 724-776-4970 (outside USA)Fax: 724-776-0790Email: CustomerService@ SAE WEB ADDRESS:h ttp://J2012Issued Revised 2007-12 (R) Diagnostic Trouble Code DefinitionsRATIONALEThe prior version of SAE J2012 was technically equivalent to a draft version of ISO 15031-6: April 30, 2002. The ISO document was subsequently edited and published as an International Standard ISO 15031-6:2005, including minor editorial changes. This version of SAE J2012 includes all of the editorial changes that were included in the published version of the ISO document. This version is updated to include; the latest standardized fault codes and failure type byte subfaults, provide a new fault code appendix format and remove certain figures that belong in the SAE J1930 standard. SAE is offering the current Diagnostic Trouble Code (DTC) and Failure Type Byte (FTB) appendices in a new Digital DTC and FTB appendices web tool.FOREWORDOn-Board Diagnostic (OBD) regulations require passenger cars, and light and medium duty trucks, to report standardized fault codes for malfunctions detected by the OBD system. This document defines the standardized set of fault codes. SAE J2012 was originally developed to meet U.S. OBD requirements for 1996 and later model year vehicles. ISO 15031-6 was based on SAE J1962 and was intended to meet European OBD requirements for 2000 and later model year vehicles. This document is technically equivalent to ISO 15031-6, with new and revised fault codes included.TABLE OF CONTENTS1. SCOPE..........................................................................................................................................................2 1.1 Purpose.........................................................................................................................................................2 1.2 Differences from ISO Document...................................................................................................................32. REFERENCES..............................................................................................................................................3 2.1 Applicable Publications.................................................................................................................................3 2.1.1 SAE Publications...........................................................................................................................................3 2.1.2 ISO Publications............................................................................................................................................33. DEFINITIONS ...............................................................................................................................................4 3.1 Circuit/Open..................................................................................................................................................4 3.2 Range/Performance......................................................................................................................................4 3.3 Low Input.......................................................................................................................................................4 3.4 High Input......................................................................................................................................................4 3.5 Bank..............................................................................................................................................................4 3.6 Sensor Location............................................................................................................................................4 3.7 Left/Right and Front/Rear .............................................................................................................................4 3.8 "A" "B"...........................................................................................................................................................4 3.9Intermittent/Erratic (4)--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---4.GENERAL SPECIFICATIONS (5)5.FORMAT STRUCTURE (5)5.1Description (5)5.2ISO/SAE Controlled Codes (Core DTCs) (7)5.3Manufacturer Controlled Codes (Non-Uniform DTCs) (7)5.4Body System Groupings (7)5.4.1B0XXX ISO/SAE Controlled (7)5.4.2B1XXX Manufacturer Controlled (7)5.4.3B2XXX Manufacturer Controlled (7)5.4.4B3XXX Reserved by Document (7)5.5Chassis System Groupings (7)5.5.1C0XXX ISO/SAE Controlled (7)5.5.2C1XXX Manufacturer Controlled (7)5.5.3C2XXX Manufacturer Controlled (7)5.5.4C3XXX Reserved by Document (7)5.6Powertrain System Groupings (8)5.6.1P0XXX ISO/SAE Controlled (8)5.6.2P1XXX Manufacturer Control (8)5.6.3P2XXX ISO/SAE Controlled (8)5.6.4P3XXX Manufacturer Controlled and ISO/SAE Reserved (8)5.7Network Groupings (8)5.7.1U0XXX ISO/SAE Controlled (8)5.7.2U1XXX Manufacturer Controlled (8)5.7.3U2XXX Manufacturer Controlled (8)5.7.4U3XXX Manufacturer Controlled and ISO/SAE Reserved (8)6.DIAGNOSTIC TROUBLE CODE DESCRIPTIONS (8)6.1Diagnostic Trouble Code Application (8)6.2Powertrain Systems (8)6.3Body Systems (9)6.4Chassis Systems (9)6.5Network and Vehicle Integration Systems (9)7.CHANGE REQUESTS (9)8.NOTES (11)8.1Marginal Indicia (11)APPENDIX A0 - (NORMATIVE) DIAGNOSTIC TROUBLE CODE NAMING GUIDELINES (12)APPENDIX B0 - BODY SYSTEMS (15)APPENDIX C0 - CHASSIS SYSTEMS (20)APPENDIX D0 - POWERTRAIN SYSTEMS (24)APPENDIX E0 - NETWORK SYSTEMS (110)APPENDIX F0 - FAILURE TYPE BYTE (128)1. SCOPE1.1 PurposeThis document supersedes SAE J2012 APR2002, and is technically equivalent to ISO 15031-6:2005 with the exceptions described in Section 1.2.This document is intended to define the standardized Diagnostic Trouble Codes (DTC) that On-Board Diagnostic (OBD) systems in vehicles are required to report when malfunctions are detected.--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---This document includes:a. Diagnostic Trouble Code format.b. A standardized set of Diagnostic Trouble Codes and descriptionsc. A standardized set of Diagnostic Trouble Codes subtypes known as Failure Types1.2 Differences from ISO DocumentThe differences to the ISO document 15031-6:2005 are the removal of figures in Section 3. The figures have been moved to SAE J1930. The DTC and FTB appendixes have been updated to reflect the latest industry standardized DTC and FTB definitions.2. REFERENCES2.1 Applicable PublicationsThe following publications form a part of this specification to the extent specified herein. Unless otherwise specified, the latest issue of SAE publications shall apply.2.1.1 SAEPublicationsAvailable from SAE International, 400 Commonwealth Drive, Warrendale, PA 15096-0001, Tel: 877-606-7323 (inside USA and Canada) or 724-776-4970 (outside USA), .SAE J1930 Electrical/Electronic Systems Diagnostic Terms, Definitions, Abbreviations, and AcronymsSAE J1978 OBD II Scan ToolSAE J1979 E/E Diagnostic Test Modes--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---2.1.2 ISOPublicationsAvailable from ANSI, 25 West 43rd Street, New York, NY 10036-8002, Tel: 212-642-4900, .ISO/TR 15031-2:2004 Road vehicles—Communication between vehicle and external equipment for emissions-related diagnostics—Part 2: Terms, definitions, abbreviations and acronymsISO 15031-4:2005 Road vehicles—Communication between vehicle and external test equipment for emissions-related diagnostics—Part 4: External test equipmentISO 15031-5:2006 Road vehicles—Communication between vehicle and external test equipment for emissions-related diagnostics—Part 5: Emissions related diagnostic servicesISO 15031-6:2005 Road vehicles—Communication between vehicle and external test equipment for emissions-related diagnostics—Part 6: Diagnostic trouble code definitionsISO 14229-1 Road vehicles—Unified diagnostics services (UDS)—Part 1: Specification and requirements3. DEFINITIONSThis document is not intended to be used for terms and definitions of vehicle component terminology. Many related vehicle technologies are defined in SAE J1930. 3.1 Circuit/OpenFixed value or no response from the system where specific high or low detection is not feasible or can be used in conjunction with circuit low and high codes where all three circuit conditions can be detected. 3.2 Range/PerformanceCircuit is in the normal operating range, but not correct for current operating conditions, it may be used to indicate stuck or skewed values indicating poor performance of a circuit, component, or system. 3.3 Low InputCircuit voltage, frequency, or other characteristic measured at the control module input terminal or pin that is below the normal operating range. 3.4 High InputCircuit voltage, frequency, or other characteristic measured at the control module input terminal or pin that is above the normal operating range. 3.5 BankSpecific group of cylinders sharing a common control sensor, bank 1 always contains cylinder number 1, bank 2 is the opposite bank.NOTE: If there is only one bank, use bank #1 DTCs and the word bank may be omitted. With a single "bank" systemusing multiple sensors, use bank #1. 3.6 Sensor LocationLocation of a sensor in relation to the engine air flow, starting from the fresh air intake through to the vehicle tailpipe or fuel flow from the fuel tank to the engine in order numbering 1,2,3 and so on. 3.7Left/Right and Front/RearComponent identified by its position as if it can be viewed from the drivers seating position. 3.8 "A" "B"Where components are indicated by a letter (e.g., A, B, C, etc.) this would be manufacturer defined. 3.9 Intermittent/ErraticThe signal is temporarily discontinuous, the duration of the fault is not sufficient to be considered an open or short, or the rate of change is excessive.--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---4. GENERAL SPECIFICATIONSThe following table specifies systems, code categories, hexadecimal values and particular sections of electrical/electronic systems diagnostic.TABLE 1 - GENERAL CODE SPECIFICATIONSSystem Code Categories Hex Value AppendixBody B0xxx - B3xxx8xxx - B xxx B0Chassis C0xxx - C3xxx4xxx - 7xxx C0Powertrain P0xxx - P3xxx0xxx - 3xxx P0Network U0xxx - U3xxx C xxx - F xxx U0The recommended DTCs consist of a three digit hexadecimal code preceded by an alphanumeric designator. The alphanumeric designators are "B0", "B1", B2", "B3", "C0", "C1", C2", "C3", "P0", "P1", P2", "P3", "U0", "U1", U2", "U3", corresponding to four sets of body, four sets of chassis, four sets of powertrain and four sets of network trouble codes. The code structure itself is partially open-ended. A portion of the available numeric sequences (portions of "B0", "C0", "P0", “P2”, “P3”, "U0", and “U3”) is reserved for uniform codes assigned by this or future updates. Detailed specifications of the DTC format structure are specified in Section 5.Most circuit, component, or system diagnostic trouble codes that do not support a subfault strategy are specified by four basic categories:— General Circuit /Open— Range/Performance— Circuit Low— Circuit HighCircuit Low is measured with the external circuit, component, or system connected. The signal type (voltage, frequency, etc.) shall be included in the message after Circuit Low.Circuit High is measured with the external circuit, component, or system connected. The signal type (voltage, frequency, etc.) may be included in the message after Circuit High.5. FORMAT STRUCTURE--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---5.1 DescriptionThe diagnostic trouble code consists of an alphanumeric designator, B0 -- B3 for body, C0 -- C3 for chassis, P0 -- P3 for powertrain, and U0 -- U3 for network communication, followed by a hexadecimal number. The assignment of the proper alpha designator should be determined by the area most appropriate for that function. In most cases, the alpha designator will be implied since diagnostic information will be requested from a particular controller. However, this does not imply that all codes supported by a particular controller shall have the same alphanumeric designator. The codes are structured as in Figure 1.FIGURE 1 - STRUCTURE OF DIAGNOSTIC TROUBLE CODESEXAMPLE: The 2-byte DTC as a data bus value $9234 would be displayed to technicians as the manufacturer controlled body code B1234, see Figure 2.DTC HIGH BYTE DTC LOW BYTE$9 $2$3 $41 0 0 1 0 0 1 0 0 0 1 1 0 1 0 0B 1 2 3 4FIGURE 2 - EXAMPLE OF 2-BYTE DIAGNOSTIC TROUBLE CODE STRUCTUREEXAMPLE: The 3-byte DTC as a data bus value $923400 would be displayed to technicians as the manufacturer controlled body code B1234-00, see Figure 3. See appendix FTB for DTC Low Byte (Failure Type Byte)definitions. The low byte shall be displayed in hexadecimal format, e.g. $1A shall be displayed as 1A.DTC HIGH BYTE DTC MIDDLE BYTE DTC LOW BYTE$3 $4 $0 $0 $9 $21 0 0 1 0 0 1 0 0 0 1 1 0 1 0 0 0 0 0 0 0 0 0 0B 1 2 3 4 0 0FIGURE 3 - EXAMPLE OF 3-BYTE DIAGNOSTIC TROUBLE CODE STRUCTURE--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---Codes have been specified to indicate a suspected trouble or problem area and are intended to be used as a directive to the proper service procedure. To minimize service confusion, fault codes should not be used to indicate the absence of problems or the status of parts of the system, (e.g. powertrain system O.K., or MIL activated), but should be confined to indicate areas in need of service attention.Ranges have been expanded from 100 numbers to 256 by using the hexadecimal base 16 number system.5.2 ISO/SAE Controlled Codes (Core DTCs)ISO/SAE controlled diagnostic trouble codes are those codes where industry uniformity has been achieved. These codes are common enough across most manufacturers' applications that a common number and fault message could be assigned. All unspecified numbers in each grouping are ISO/SAE reserved for future growth. Although service procedures may differ widely amongst manufacturers, the fault being indicated is common enough to be assigned a particular fault code. Codes in this area are not to be used by manufacturers until they have been approved by ISO/SAE.5.3 Manufacturer Controlled Codes (Non-Uniform DTCs)Areas within each alpha designator have been made available for manufacturer-controlled DTCs. These are fault codes that will not generally be used by a majority of the manufacturers due to basic system differences, implementation differences, or diagnostic strategy differences. Each vehicle manufacturer or supplier who designs and specifies diagnostic algorithms, software, and diagnostic trouble codes are strongly encouraged to remain consistent across their product line when assigning codes in the manufacturer controlled area. For powertrain codes, where possible, the same groupings should be used as in the ISO/SAE controlled area, i.e. 100's and 200's for fuel and air metering, 300's for ignition system or misfire, etc.While each manufacturer has the ability to define the controlled DTCs to meet their specific controller algorithms, all DTC descriptions shall meet SAE J1930 or ISO 15031-2.5.4 Body System GroupingsDTC numbers and descriptions are given in appendix B0.5.4.1 B0XXX ISO/SAE Controlled5.4.2 B1XXX Manufacturer Controlled5.4.3 B2XXX Manufacturer Controlled5.4.4 B3XXX Reserved by Document5.5 Chassis System GroupingsDTC numbers and descriptions are given in appendix C0.5.5.1 C0XXX ISO/SAE Controlled5.5.2 C1XXX Manufacturer Controlled5.5.3 C2XXX Manufacturer Controlled5.5.4 C3XXX Reserved by Document--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---5.6 Powertrain System GroupingsDTC numbers and descriptions are given in appendix P0.5.6.1 P0XXX ISO/SAE Controlled5.6.2 P1XXX Manufacturer Control5.6.3 P2XXX ISO/SAE Controlled5.6.4 P3XXX Manufacturer Controlled and ISO/SAE Reserved5.7 Network GroupingsDTC numbers and descriptions are given in appendix U0.--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---5.7.1 U0XXX ISO/SAE Controlled5.7.2 U1XXX Manufacturer Controlled5.7.3 U2XXX Manufacturer Controlled5.7.4 U3XXX Manufacturer Controlled and ISO/SAE Reserved6. DIAGNOSTIC TROUBLE CODE DESCRIPTIONS6.1 Diagnostic Trouble Code ApplicationRecent developments have expanded the scope of this documentation to include additional DTCs and descriptions for network systems, body systems, and chassis systems. Two different DTC application methods are required depending on the system. Powertrain DTCs require the assignment of a unique DTC number and description for each failure mode (e.g.: circuit low, circuit high, rationality, etc). Body and chassis systems descriptions are more general and require the assignment of a single DTC number and description for each component, not failure mode. Unique body and chassis failure mode identification is still possible, but is dependent upon using diagnostic protocols that support a subfault failure strategy. One example is ISO 14229-1, which uses a “Failure Type Byte” associated with each DTC to describe the failure mode (e.g.: circuit low, circuit high, rationality, etc). However any protocol supporting a subfault strategy will work with these DTCs. Manufacturers must select the appropriate failure mode to apply to the base DTC description.6.2 Powertrain SystemsThe powertrain systems category covers functions that include engine, transmission and associated drivetrain accessories. For powertrain systems, each specified fault code has been assigned a description to indicate the circuit, component or system area that was determined to be at fault. The descriptions are organized such that different descriptions related to a particular sensor or system are grouped together. In cases where there are various fault descriptions for different types of faults, the group also has a "generic" description as the first code/message of the group.A manufacturer has a choice when implementing diagnostics, based on the specific strategy and complexity of the diagnostic.Where more specific fault descriptions for a circuit, component, or system exist, the manufacturer should choose the code most applicable to their diagnosable fault. The descriptions are intended to be somewhat general to allow manufacturers to use them as often as possible yet still not conflict with their specific repair procedures. The terms "low" and "high" when used in a description, especially those related to input signals, refer to the voltage, frequency, etc. at the pin of the controller. The specific level of "low" and "high" shall be specified by each manufacturer to best meet their needs.For example, in diagnosing a 5 V reference Throttle Position Sensor (TP Sensor), if the input signal at the Powertrain Control Module (PCM) is stuck at near 0 V, a manufacturer has the flexibility to select from either of two codes - P0120 (Throttle/Pedal Position Sensor/Switch A Circuit) or P0122 (Throttle/Pedal Position Sensor/Switch A Circuit Low), depending on the manufacturer's diagnostic procedures. If the input signal at the PCM is stuck at near 5 V, a manufacturer has the flexibility to select from either of two codes - P0120 (Throttle/Pedal Position Sensor/Switch A Circuit) or P0123 (Throttle/Pedal Position Sensor/Switch A Circuit High), depending on the manufacturer's diagnostic procedures. If the input signal at the PCM is stuck at 1.5 V at idle instead of the expected 1.0 V, the manufacturer has the flexibility to select from either of two codes - P0120 (Throttle/Pedal Position Sensor/Switch A Circuit) or P0121 (Throttle/Pedal Position Sensor/Switch A Circuit Range/Performance), depending on the manufacturer's diagnostic procedures. The root cause of the higher than expected TP Sensor voltage may be either a faulty TP Sensor, corrosion in the TP Sensor connections or an improperly adjusted throttle plate. Identification of the root cause is done using the diagnostic procedures and is not implied by the DTC message, thus allowing the manufacturer the flexibility in assigning DTCs.6.3 Body SystemsThe body systems category covers functions that are, generally, inside of the passenger compartment. These functions provide the vehicle occupants with assistance, comfort, convenience, and safety. Each specified trouble code has been assigned a description to indicate the component or system area that was determined to be at fault. Unlike powertrain systems, the body system trouble code descriptions are intended to be general. Powertrain DTCs typically include separate DTCs for each failure mode (e.g.: circuit low, circuit high, rationality, etc) within each DTC description. Body system DTCs are designed to only support the base component in the description, which makes these DTCs dependent upon diagnostic protocols that support a subfault failure strategy. Manufacturers must select the appropriate failure mode (e.g.: circuit short to ground, circuit short to battery, signal plausibility failure, etc) to apply to the general DTC description. The supported body subsection included in this group is currently Restraints. 6.4 Chassis SystemsThe chassis systems category covers functions that are, generally, outside of the passenger compartment. These functions typically include mechanical systems such as brakes, steering and suspension. Each specified trouble code has been assigned a description to indicate the component or system area that was determined to be at fault. Unlike powertrain systems, the chassis system trouble code descriptions are intended to be general. Powertrain DTCs typically include separate DTCs for each failure mode (e.g.: circuit low, circuit high, rationality, etc) within each DTC description. Chassis system DTCs are designed to only support the base component in the description, which makes these DTCs dependent upon diagnostic protocols that support a subfault failure strategy. Manufacturers must select the appropriate failure mode (e.g.: circuit short to ground, circuit short to battery, signal plausibility failure, etc) to apply to the general DTC description. The supported chassis subsections included in this group are currently Brakes and Traction Control. 6.5Network and Vehicle Integration SystemsThe network communication and vehicle integration systems category covers functions that are shared among computers and/or systems on the vehicle. Each specified trouble code has been assigned a description to indicate the component or system area that was determined to be at fault. The descriptions of data links are intended to be general in order to allow manufacturers to use them for different communication protocols. The descriptions of control modules are intended to be general in order to allow manufacturers to reuse the DTC for new control modules as technologies evolve. Also, the descriptions may be supplemented with additional subfault information such as the “Failure Type Byte” data defined in appendix FTB. The subsections included in this group are Network Electrical, Network Communication, Network Software, Network Data, and Control Module/Power Distribution. 7. CHANGE REQUESTSUse this form to request new industry standard DTCs.--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---Request Form for New ISO 15031-6/SAE J2012 Controlled DTC What is the purpose of the component, circuit, or system?Example: Exhaust Gas Recirculation.What is the purpose of the diagnostic?Example: detect low EGR flowRequested Group Number_________________________________________________ Requested DTC Number__________________________________________________ Requested DTC Nomenclature_____________________________________________ Example: EGR Low Flow DetectedRequested by:__________________________________________________________ Phone/Fax_________________________________________Email______________________________________________Address____________________________________________Date:Please send completed form(s) either to:FAKRA Normenausschuß Kraftfahrzeuge Postfach 17 05 63D-60079 Frankfurt/MainGermanyATTN: ISO/TC22/SC3/WG1SAE Headquarters755 West Big Beaver RoadSuite 1600Troy, MI 48084USAATTN: J2012 Committee Chairman--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---8. NOTES8.1 Marginal IndiciaThe change bar (l) located in the left margin is for the convenience of the user in locating areas where technical revisions have been made to the previous issue of the report. An (R) symbol to the left of the document title indicates a complete revision of the report.PREPARED BY THE SAE VEHICLE ELECTRICAL AND ELECTRONICSDIAGNOSTIC SYSTEMS STANDARDS COMMITTEE--``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---APPENDIX A0 - (NORMATIVE)DIAGNOSTIC TROUBLE CODE NAMING GUIDELINESA.1 DISCUSSIONTables A01, A02, A03, A04 provide guidelines to help in determining DTC descriptions.Appendix B0 shows applications for recommended industry common trouble codes for the body systems, Appendix C0 shows applications for chassis systems, Appendix P0 shows applications for powertrain systems and Appendix U0 shows applications for network control systems. The DTCs in appendix P0 include systems that might be integrated into an electronic control module that would be used for controlling engine functions, such as fuel, spark, idle speed, and vehicle speed (cruise control), as well as those for transmission control. The fact that a code is recommended as a common industry code does not imply that it is a required code (legislated), an emission related code, nor that it indicates a fault that will cause the malfunction indicator to be illuminated.TABLE A01 - DTC NAMING GUIDELINES FOR SIGNALS FROM COMPONENTSComponent/System ISO 15031-2/SAE J1930(1)AcronymISO 15031-2/SAEJ1930(1)Modifier(if used)(1) Noun Name(1)Circuit(1)Intermittent(if used)(1)State(if used)(1)Parameter(if used)(1)Location(if used)(1)ThrottlePosition TP Sensor Circuit Low Voltage Throttle Position TP Sensor Circuit PerformanceManifold Absolute Pressure MAPSensor Circuit High VoltageEngine CoolantTemperatureECT Sensor Circuit Low Voltage Intake Air Temperature IAT Sensor Circuit High VoltageVehicle Speed Sensor VSS included inacronymCircuit High VoltageVehicle Speed Sensor VSS included inacronymCircuit IntermittentHeated Oxygen Sensor HO2S included inacronymCircuitHeated Oxygen Sensor HO2S included inacronym Circuit Low Voltage Bank (B1)Sensor 1 (S1)Idle Air Control IAC Valve Circuit Low VoltageMass Air Flow MAF Sensor Circuit High FrequencyMass Air Flow MAF Sensor Circuit PerformanceKnock Sensor KS included inacronymCircuit Bank 1Knock Sensor KS included inacronymCircuit PerformanceCrankshaft Position CKP Sensor CircuitEvaporative Emissions EVAP CanisterPurgeValve CircuitEngine Speed RPM InputCircuitAir Conditioning A/C Clutch N/A Circuit LowVoltage --``,,`,``,,`,`,``,``,,,``,``,`,-`-`,,`,,`,`,,`---。
SPSS术语中英文对照
【常用软件】SPSS术语中英文对照SPSS的统计分析过程均包含在Analysis菜单中。
我们只学以下两大分析过程:Descriptive Statistics(描述性统计)和Multiple Response(多选项分析)。
Descriptive Statistics(描述性统计)包含的分析功能:1.Frequencies 过程:主要用于统计指定变量各变量值的频次(Frequency)、百分比(Percent).2.Descriptives过程:主要用于计算指定变量的均值(Mean)、标准差(Std.Deviation).3.Crosstabs 过程:主要用于两个或两个以上变量的交叉分类。
Multiple Response(多选项分析)的分析功能:1.Define Set过程:该过程定义一个由多选项组成的多响应变量.2.Frequencies过程:该过程对定义的多响应变量提供一个频数表。
3.Crosstabs过程:该过程提供所定义的多响应变量与其他变量的交叉分类表。
Absolute deviation,绝对离差Absolute number,绝对数Absolute residuals,绝对残差Acceleration array, 加速度立体阵Acceleration in an arbitrary direction,任意方向上的加速度Acceleration normal, 法向加速度Acceleration space dimension, 加速度空间的维数Acceleration tangential,切向加速度Acceleration vector,加速度向量Acceptable hypothesis, 可接受假设Accumulation,累积Accuracy, 准确度Actual frequency, 实际频数Adaptive estimator,自适应估计量Addition,相加Addition theorem,加法定理Additivity, 可加性Adjusted rate, 调整率Adjusted value,校正值Admissible error, 容许误差Aggregation,聚集性Alternative hypothesis,备择假设Among groups,组间Amounts, 总量Analysis of correlation,相关分析Analysis of covariance,协方差分析Analysis of regression, 回归分析Analysis of time series,时间序列分析Analysis of variance,方差分析Angular transformation, 角转换ANOVA (analysis of variance), 方差分析ANOVA Models,方差分析模型Arcing,弧/弧旋Arcsine transformation,反正弦变换Area under the curve,曲线面积AREG , 评估从一个时间点到下一个时间点回归相关时的误差ARIMA, 季节和非季节性单变量模型的极大似然估计Arithmetic grid paper, 算术格纸Arithmetic mean, 算术平均数Arrhenius relation,艾恩尼斯关系Assessing fit,拟合的评估Associative laws,结合律Asymmetric distribution, 非对称分布Asymptotic bias, 渐近偏倚Asymptotic efficiency, 渐近效率Asymptotic variance,渐近方差Attributable risk, 归因危险度Attribute data, 属性资料Attribution,属性Autocorrelation,自相关Autocorrelation of residuals,残差的自相关Average, 平均数Average confidence interval length, 平均置信区间长度Average growth rate, 平均增长率Bar chart, 条形图Bar graph, 条形图Base period,基期Bayes‘ theorem ,Bayes定理Bell-shaped curve, 钟形曲线Bernoulli distribution, 伯努力分布Best-trim estimator,最好切尾估计量Bias,偏性Binary logistic regression, 二元逻辑斯蒂回归Binomial distribution,二项分布Bisquare, 双平方Bivariate Correlate,二变量相关Bivariate normal distribution, 双变量正态分布Bivariate normal population, 双变量正态总体Biweight interval,双权区间Biweight M-estimator,双权M估计量Block,区组/配伍组BMDP(Biomedical computer programs), BMDP统计软件包Boxplots, 箱线图/箱尾图Breakdown bound, 崩溃界/崩溃点Canonical correlation, 典型相关Caption, 纵标目Case—control study, 病例对照研究Categorical variable, 分类变量Catenary, 悬链线Cauchy distribution, 柯西分布Cause-and—effect relationship,因果关系Cell,单元Censoring,终检Center of symmetry,对称中心Centering and scaling, 中心化和定标Central tendency, 集中趋势Central value, 中心值CHAID —χ2 Automatic Interaction Detector,卡方自动交互检测Chance, 机遇Chance error,随机误差Chance variable,随机变量Characteristic equation, 特征方程Characteristic root,特征根Characteristic vector, 特征向量Chebshev criterion of fit,拟合的切比雪夫准则Chernoff faces, 切尔诺夫脸谱图Chi-square test,卡方检验/χ2检验Choleskey decomposition,乔洛斯基分解Circle chart,圆图Class interval, 组距Class mid—value, 组中值Class upper limit, 组上限Classified variable,分类变量Cluster analysis,聚类分析Cluster sampling,整群抽样Code,代码Coded data,编码数据Coding,编码Coefficient of contingency, 列联系数Coefficient of determination, 决定系数Coefficient of multiple correlation,多重相关系数Coefficient of partial correlation,偏相关系数Coefficient of production-moment correlation, 积差相关系数Coefficient of rank correlation, 等级相关系数Coefficient of regression, 回归系数Coefficient of skewness,偏度系数Coefficient of variation, 变异系数Cohort study, 队列研究Column,列Column effect,列效应Column factor,列因素Combination pool,合并Combinative table,组合表Common factor, 共性因子Common regression coefficient,公共回归系数Common value,共同值Common variance, 公共方差Common variation,公共变异Communality variance,共性方差Comparability, 可比性Comparison of bathes,批比较Comparison value, 比较值Compartment model, 分部模型Compassion, 伸缩Complement of an event,补事件Complete association, 完全正相关Complete dissociation, 完全不相关Complete statistics,完备统计量Completely randomized design,完全随机化设计Composite event, 联合事件Composite events,复合事件Concavity, 凹性Conditional expectation, 条件期望Conditional likelihood,条件似然Conditional probability,条件概率Conditionally linear,依条件线性Confidence interval, 置信区间Confidence limit,置信限Confidence lower limit,置信下限Confidence upper limit,置信上限Confirmatory Factor Analysis ,验证性因子分析Confirmatory research, 证实性实验研究Confounding factor,混杂因素Conjoint,联合分析Consistency,相合性Consistency check, 一致性检验Consistent asymptotically normal estimate, 相合渐近正态估计Consistent estimate,相合估计Constrained nonlinear regression, 受约束非线性回归Constraint, 约束Contaminated distribution,污染分布Contaminated Gausssian,污染高斯分布Contaminated normal distribution, 污染正态分布Contamination,污染Contamination model,污染模型Contingency table,列联表Contour, 边界线Contribution rate,贡献率Control,对照Controlled experiments, 对照实验Conventional depth, 常规深度Convolution,卷积Corrected factor,校正因子Corrected mean, 校正均值Correction coefficient, 校正系数Correctness, 正确性Correlation coefficient, 相关系数Correlation index, 相关指数Correspondence,对应Counting,计数Counts,计数/频数Covariance, 协方差Covariant,共变Cox Regression,Cox回归Criteria for fitting,拟合准则Criteria of least squares, 最小二乘准则Critical ratio,临界比Critical region,拒绝域Critical value,临界值Cross-over design,交叉设计Cross—section analysis, 横断面分析Cross—section survey,横断面调查Crosstabs ,交叉表Cross-tabulation table,复合表Cube root, 立方根Cumulative distribution function,分布函数Cumulative probability,累计概率Curvature, 曲率/弯曲Curvature, 曲率Curve fit ,曲线拟和Curve fitting,曲线拟合Curvilinear regression,曲线回归Curvilinear relation,曲线关系Cut-and-try method,尝试法Cycle,周期Cyclist, 周期性D test,D检验Data acquisition,资料收集Data bank,数据库Data capacity, 数据容量Data deficiencies, 数据缺乏Data handling,数据处理Data manipulation, 数据处理Data processing, 数据处理Data reduction, 数据缩减Data set,数据集Data sources, 数据来源Data transformation, 数据变换Data validity, 数据有效性Data—in, 数据输入Data-out,数据输出Dead time, 停滞期Degree of freedom, 自由度Degree of precision,精密度Degree of reliability, 可靠性程度Degression,递减Density function,密度函数Density of data points, 数据点的密度Dependent variable,应变量/依变量/因变量Dependent variable, 因变量Depth, 深度Derivative matrix,导数矩阵Derivative—free methods,无导数方法Design, 设计Determinacy, 确定性Determinant, 行列式Determinant,决定因素Deviation,离差Deviation from average,离均差Diagnostic plot,诊断图Dichotomous variable,二分变量Differential equation,微分方程Direct standardization,直接标准化法Discrete variable,离散型变量DISCRIMINANT,判断Discriminant analysis,判别分析Discriminant coefficient, 判别系数Discriminant function,判别值Dispersion,散布/分散度Disproportional, 不成比例的Disproportionate sub—class numbers, 不成比例次级组含量Distribution free,分布无关性/免分布Distribution shape,分布形状Distribution—free method,任意分布法Distributive laws,分配律Disturbance, 随机扰动项Dose response curve, 剂量反应曲线Double blind method,双盲法Double blind trial, 双盲试验Double exponential distribution, 双指数分布Double logarithmic,双对数Downward rank, 降秩Dual-space plot,对偶空间图DUD,无导数方法Duncan‘s new multiple range method, 新复极差法/Duncan新法Effect, 实验效应Eigenvalue, 特征值Eigenvector, 特征向量Ellipse, 椭圆Empirical distribution,经验分布Empirical probability, 经验概率单位Enumeration data, 计数资料Equal sun—class number, 相等次级组含量Equally likely, 等可能Equivariance, 同变性Error, 误差/错误Error of estimate,估计误差Error type I,第一类错误Error type II, 第二类错误Estimand,被估量Estimated error mean squares, 估计误差均方Estimated error sum of squares, 估计误差平方和Euclidean distance, 欧式距离Event, 事件Event, 事件Exceptional data point, 异常数据点Expectation plane, 期望平面Expectation surface,期望曲面Expected values,期望值Experiment, 实验Experimental sampling,试验抽样Experimental unit, 试验单位Explanatory variable,说明变量Exploratory data analysis, 探索性数据分析Explore Summarize, 探索-摘要Exponential curve, 指数曲线Exponential growth,指数式增长EXSMOOTH, 指数平滑方法Extended fit,扩充拟合Extra parameter,附加参数Extrapolation,外推法Extreme observation,末端观测值Extremes, 极端值/极值F distribution, F分布F test, F检验Factor, 因素/因子Factor analysis, 因子分析Factor Analysis,因子分析Factor score, 因子得分Factorial, 阶乘Factorial design,析因试验设计False negative, 假阴性False negative error,假阴性错误Family of distributions,分布族Family of estimators,估计量族Fanning,扇面Fatality rate,病死率Field investigation, 现场调查Field survey,现场调查Finite population,有限总体Finite—sample,有限样本First derivative,一阶导数First principal component,第一主成分First quartile, 第一四分位数Fisher information,费雪信息量Fitted value, 拟合值Fitting a curve, 曲线拟合Fixed base, 定基Fluctuation, 随机起伏Forecast,预测Four fold table, 四格表Fourth,四分点Fraction blow, 左侧比率Fractional error,相对误差Frequency,频率Frequency polygon,频数多边图Frontier point,界限点Function relationship,泛函关系Gamma distribution, 伽玛分布Gauss increment,高斯增量Gaussian distribution, 高斯分布/正态分布Gauss-Newton increment,高斯—牛顿增量General census,全面普查GENLOG (Generalized liner models),广义线性模型Geometric mean,几何平均数Gini‘s mean difference, 基尼均差GLM (General liner models),一般线性模型Goodness of fit, 拟和优度/配合度Gradient of determinant, 行列式的梯度Graeco—Latin square, 希腊拉丁方Grand mean, 总均值Gross errors, 重大错误Gross-error sensitivity, 大错敏感度Group averages,分组平均Grouped data, 分组资料Guessed mean, 假定平均数Half-life,半衰期Hampel M—estimators, 汉佩尔M估计量Happenstance,偶然事件Harmonic mean,调和均数Hazard function, 风险均数Hazard rate, 风险率Heading,标目Heavy—tailed distribution,重尾分布Hessian array, 海森立体阵Heterogeneity,不同质Heterogeneity of variance,方差不齐Hierarchical classification, 组内分组Hierarchical clustering method,系统聚类法High—leverage point, 高杠杆率点HILOGLINEAR, 多维列联表的层次对数线性模型Hinge,折叶点Histogram, 直方图Historical cohort study,历史性队列研究Holes,空洞HOMALS,多重响应分析Homogeneity of variance,方差齐性Homogeneity test,齐性检验Huber M—estimators, 休伯M估计量Hyperbola,双曲线Hypothesis testing, 假设检验Hypothetical universe, 假设总体Impossible event, 不可能事件Independence, 独立性Independent variable,自变量Index,指标/指数Indirect standardization,间接标准化法Individual, 个体Inference band, 推断带Infinite population,无限总体Infinitely great,无穷大Infinitely small, 无穷小Influence curve, 影响曲线Information capacity,信息容量Initial condition, 初始条件Initial estimate,初始估计值Initial level, 最初水平Interaction, 交互作用Interaction terms,交互作用项Intercept,截距Interpolation,内插法Interquartile range,四分位距Interval estimation, 区间估计Intervals of equal probability,等概率区间Intrinsic curvature,固有曲率Invariance, 不变性Inverse matrix,逆矩阵Inverse probability, 逆概率Inverse sine transformation,反正弦变换Iteration, 迭代Jacobian determinant,雅可比行列式Joint distribution function,分布函数Joint probability, 联合概率Joint probability distribution, 联合概率分布K means method, 逐步聚类法Kaplan—Meier, 评估事件的时间长度Kaplan—Merier chart,Kaplan-Merier图Kendall‘s rank correlation, Kendall等级相关Kinetic, 动力学Kolmogorov—Smirnove test, 柯尔莫哥洛夫-斯米尔诺夫检验Kruskal and Wallis test, Kruskal及Wallis检验/多样本的秩和检验/H检验Kurtosis,峰度Lack of fit, 失拟Ladder of powers, 幂阶梯Lag, 滞后Large sample, 大样本Large sample test,大样本检验Latin square,拉丁方Latin square design, 拉丁方设计Leakage,泄漏Least favorable configuration, 最不利构形Least favorable distribution, 最不利分布Least significant difference, 最小显著差法Least square method,最小二乘法Least-absolute-residuals estimates, 最小绝对残差估计Least—absolute-residuals fit, 最小绝对残差拟合Least-absolute-residuals line,最小绝对残差线Legend,图例L—estimator, L估计量L—estimator of location, 位置L估计量L—estimator of scale,尺度L估计量Level,水平Life expectance, 预期期望寿命Life table, 寿命表Life table method, 生命表法Light—tailed distribution, 轻尾分布Likelihood function,似然函数Likelihood ratio, 似然比line graph, 线图Linear correlation,直线相关Linear equation, 线性方程Linear programming,线性规划Linear regression, 直线回归Linear Regression, 线性回归Linear trend,线性趋势Loading,载荷Location and scale equivariance, 位置尺度同变性Location equivariance,位置同变性Location invariance, 位置不变性Location scale family,位置尺度族Log rank test, 时序检验Logarithmic curve, 对数曲线Logarithmic normal distribution,对数正态分布Logarithmic scale,对数尺度Logarithmic transformation, 对数变换Logic check,逻辑检查Logistic distribution,逻辑斯特分布Logit transformation, Logit转换LOGLINEAR, 多维列联表通用模型Lognormal distribution,对数正态分布Lost function,损失函数Low correlation, 低度相关Lower limit, 下限Lowest-attained variance, 最小可达方差LSD, 最小显著差法的简称Lurking variable, 潜在变量Main effect,主效应Major heading, 主辞标目Marginal density function,边缘密度函数Marginal probability,边缘概率Marginal probability distribution,边缘概率分布Matched data, 配对资料Matched distribution, 匹配过分布Matching of distribution, 分布的匹配Matching of transformation, 变换的匹配Mathematical expectation, 数学期望Mathematical model,数学模型Maximum L-estimator, 极大极小L 估计量Maximum likelihood method, 最大似然法Mean,均数Mean squares between groups, 组间均方Mean squares within group, 组内均方Means (Compare means), 均值-均值比较Median, 中位数Median effective dose,半数效量Median lethal dose, 半数致死量Median polish, 中位数平滑Median test,中位数检验Minimal sufficient statistic, 最小充分统计量Minimum distance estimation, 最小距离估计Minimum effective dose,最小有效量Minimum lethal dose, 最小致死量Minimum variance estimator, 最小方差估计量MINITAB,统计软件包Minor heading,宾词标目Missing data, 缺失值Model specification,模型的确定Modeling Statistics ,模型统计Models for outliers, 离群值模型Modifying the model,模型的修正Modulus of continuity, 连续性模Morbidity, 发病率Most favorable configuration, 最有利构形Multidimensional Scaling (ASCAL),多维尺度/多维标度Multinomial Logistic Regression , 多项逻辑斯蒂回归Multiple comparison, 多重比较Multiple correlation , 复相关Multiple covariance,多元协方差Multiple linear regression,多元线性回归Multiple response , 多重选项Multiple solutions, 多解Multiplication theorem,乘法定理Multiresponse, 多元响应Multi—stage sampling, 多阶段抽样Multivariate T distribution,多元T分布Mutual exclusive,互不相容Mutual independence, 互相独立Natural boundary,自然边界Natural dead, 自然死亡Natural zero,自然零Negative correlation, 负相关Negative linear correlation, 负线性相关Negatively skewed,负偏Newman-Keuls method,q检验NK method,q检验No statistical significance, 无统计意义Nominal variable,名义变量Nonconstancy of variability, 变异的非定常性Nonlinear regression,非线性相关Nonparametric statistics, 非参数统计Nonparametric test,非参数检验Nonparametric tests, 非参数检验Normal deviate, 正态离差Normal distribution, 正态分布Normal equation, 正规方程组Normal ranges, 正常范围Normal value, 正常值Nuisance parameter,多余参数/讨厌参数Null hypothesis,无效假设Numerical variable,数值变量Objective function, 目标函数Observation unit,观察单位Observed value, 观察值One sided test, 单侧检验One—way analysis of variance,单因素方差分析Oneway ANOVA , 单因素方差分析Open sequential trial,开放型序贯设计Optrim,优切尾Optrim efficiency,优切尾效率Order statistics, 顺序统计量Ordered categories,有序分类Ordinal logistic regression , 序数逻辑斯蒂回归Ordinal variable, 有序变量Orthogonal basis,正交基Orthogonal design,正交试验设计Orthogonality conditions,正交条件ORTHOPLAN,正交设计Outlier cutoffs, 离群值截断点Outliers, 极端值OVERALS , 多组变量的非线性正规相关Overshoot,迭代过度Paired design, 配对设计Paired sample,配对样本Pairwise slopes, 成对斜率Parabola,抛物线Parallel tests,平行试验Parameter,参数Parametric statistics, 参数统计Parametric test,参数检验Partial correlation, 偏相关Partial regression,偏回归Partial sorting, 偏排序Partials residuals, 偏残差Pattern,模式Pearson curves, 皮尔逊曲线Peeling,退层Percent bar graph,百分条形图Percentage,百分比Percentile,百分位数Percentile curves,百分位曲线Periodicity,周期性Permutation, 排列P—estimator, P估计量Pie graph,饼图Pitman estimator,皮特曼估计量Pivot,枢轴量Planar,平坦Planar assumption,平面的假设PLANCARDS,生成试验的计划卡Point estimation,点估计Poisson distribution, 泊松分布Polishing,平滑Polled standard deviation, 合并标准差Polled variance,合并方差Polygon,多边图Polynomial,多项式Polynomial curve, 多项式曲线Population,总体Population attributable risk, 人群归因危险度Positive correlation, 正相关Positively skewed,正偏Posterior distribution, 后验分布Power of a test,检验效能Precision, 精密度Predicted value,预测值Preliminary analysis, 预备性分析Principal component analysis,主成分分析Prior distribution,先验分布Prior probability, 先验概率Probabilistic model,概率模型probability,概率Probability density,概率密度Product moment, 乘积矩/协方差Profile trace,截面迹图Proportion,比/构成比Proportion allocation in stratified random sampling, 按比例分层随机抽样Proportionate, 成比例Proportionate sub—class numbers, 成比例次级组含量Prospective study,前瞻性调查Proximities, 亲近性Pseudo F test, 近似F检验Pseudo model,近似模型Pseudosigma,伪标准差Purposive sampling, 有目的抽样QR decomposition,QR分解Quadratic approximation,二次近似Qualitative classification, 属性分类Qualitative method, 定性方法Quantile-quantile plot,分位数—分位数图/Q—Q图Quantitative analysis,定量分析Quartile,四分位数Quick Cluster,快速聚类Radix sort, 基数排序Random allocation, 随机化分组Random blocks design,随机区组设计Random event,随机事件Randomization, 随机化Range, 极差/全距Rank correlation, 等级相关Rank sum test,秩和检验Rank test,秩检验Ranked data,等级资料Rate,比率Ratio,比例Raw data,原始资料Raw residual, 原始残差Rayleigh‘s test, 雷氏检验Rayleigh‘s Z,雷氏Z值Reciprocal,倒数Reciprocal transformation, 倒数变换Recording, 记录Redescending estimators, 回降估计量Reducing dimensions, 降维Re—expression,重新表达Reference set, 标准组Region of acceptance, 接受域Regression coefficient,回归系数Regression sum of square, 回归平方和Rejection point, 拒绝点Relative dispersion, 相对离散度Relative number, 相对数Reliability,可靠性Reparametrization,重新设置参数Replication,重复Report Summaries, 报告摘要Residual sum of square, 剩余平方和Resistance, 耐抗性Resistant line,耐抗线Resistant technique,耐抗技术R—estimator of location,位置R估计量R-estimator of scale, 尺度R估计量Retrospective study, 回顾性调查Ridge trace, 岭迹Ridit analysis,Ridit分析Rotation, 旋转Rounding, 舍入Row, 行Row effects,行效应Row factor, 行因素RXC table,RXC表Sample,样本Sample regression coefficient, 样本回归系数Sample size, 样本量Sample standard deviation, 样本标准差Sampling error, 抽样误差SAS(Statistical analysis system ), SAS统计软件包Scale,尺度/量表Scatter diagram,散点图Schematic plot, 示意图/简图Score test,计分检验Screening, 筛检SEASON, 季节分析Second derivative, 二阶导数Second principal component,第二主成分SEM (Structural equation modeling),结构化方程模型Semi—logarithmic graph, 半对数图Semi—logarithmic paper, 半对数格纸Sensitivity curve, 敏感度曲线Sequential analysis, 贯序分析Sequential data set,顺序数据集Sequential design,贯序设计Sequential method, 贯序法Sequential test, 贯序检验法Serial tests, 系列试验Short-cut method, 简捷法Sigmoid curve, S形曲线Sign function, 正负号函数Sign test, 符号检验Signed rank, 符号秩Significance test,显著性检验Significant figure, 有效数字Simple cluster sampling,简单整群抽样Simple correlation, 简单相关Simple random sampling,简单随机抽样Simple regression, 简单回归simple table, 简单表Sine estimator,正弦估计量Single—valued estimate,单值估计Singular matrix,奇异矩阵Skewed distribution, 偏斜分布Skewness,偏度Slash distribution, 斜线分布Slope,斜率Smirnov test, 斯米尔诺夫检验Source of variation, 变异来源Spearman rank correlation, 斯皮尔曼等级相关Specific factor,特殊因子Specific factor variance,特殊因子方差Spectra ,频谱Spherical distribution, 球型正态分布Spread,展布SPSS(Statistical package for the social science),SPSS统计软件包Spurious correlation, 假性相关Square root transformation, 平方根变换Stabilizing variance,稳定方差Standard deviation,标准差Standard error, 标准误Standard error of difference,差别的标准误Standard error of estimate, 标准估计误差Standard error of rate,率的标准误Standard normal distribution, 标准正态分布Standardization,标准化Starting value, 起始值Statistic, 统计量Statistical control,统计控制Statistical graph,统计图Statistical inference,统计推断Statistical table, 统计表Steepest descent, 最速下降法Stem and leaf display,茎叶图Step factor,步长因子Stepwise regression,逐步回归Storage, 存Strata,层(复数)Stratified sampling,分层抽样Stratified sampling,分层抽样Strength,强度Stringency, 严密性Structural relationship, 结构关系Studentized residual, 学生化残差/t化残差Sub-class numbers, 次级组含量Subdividing,分割Sufficient statistic, 充分统计量Sum of products, 积和Sum of squares,离差平方和Sum of squares about regression, 回归平方和Sum of squares between groups, 组间平方和Sum of squares of partial regression, 偏回归平方和Sure event,必然事件Survey,调查Survival,生存分析Survival rate, 生存率Suspended root gram, 悬吊根图Symmetry, 对称Systematic error, 系统误差Systematic sampling, 系统抽样Tags,标签Tail area, 尾部面积Tail length, 尾长Tail weight,尾重Tangent line, 切线Target distribution,目标分布Taylor series,泰勒级数Tendency of dispersion, 离散趋势Testing of hypotheses, 假设检验Theoretical frequency,理论频数Time series, 时间序列Tolerance interval,容忍区间Tolerance lower limit,容忍下限Tolerance upper limit, 容忍上限Torsion, 扰率Total sum of square, 总平方和Total variation,总变异Transformation,转换Treatment,处理Trend, 趋势Trend of percentage,百分比趋势Trial,试验Trial and error method,试错法Tuning constant, 细调常数Two sided test, 双向检验Two-stage least squares,二阶最小平方Two—stage sampling, 二阶段抽样Two—tailed test, 双侧检验Two—way analysis of variance,双因素方差分析Two—way table,双向表Type I error,一类错误/α错误Type II error,二类错误/β错误UMVU,方差一致最小无偏估计简称Unbiased estimate,无偏估计Unconstrained nonlinear regression , 无约束非线性回归Unequal subclass number,不等次级组含量Ungrouped data,不分组资料Uniform coordinate,均匀坐标Uniform distribution,均匀分布Uniformly minimum variance unbiased estimate,方差一致最小无偏估计Unit, 单元Unordered categories,无序分类Upper limit,上限Upward rank,升秩Vague concept, 模糊概念Validity, 有效性VARCOMP (Variance component estimation),方差元素估计Variability,变异性Variable, 变量Variance, 方差Variation, 变异Varimax orthogonal rotation,方差最大正交旋转Volume of distribution,容积W test, W检验Weibull distribution, 威布尔分布Weight, 权数Weighted Chi—square test, 加权卡方检验/Cochran检验Weighted linear regression method, 加权直线回归Weighted mean,加权平均数Weighted mean square, 加权平均方差Weighted sum of square,加权平方和Weighting coefficient, 权重系数Weighting method, 加权法W-estimation,W估计量W-estimation of location,位置W估计量Width, 宽度Wilcoxon paired test,威斯康星配对法/配对符号秩和检验Wild point, 野点/狂点Wild value, 野值/狂值Winsorized mean,缩尾均值Withdraw,失访Youden‘s index, 尤登指数Z test, Z检验Zero correlation,零相关Z—transformation,Z变换。
统计学随机分组(实验动物含小鼠)-PPT
[5]万霞, 刘建平. 临床试验中的随机分组方法. 中医杂志2007 年第 48 卷第3 期
阳性对照组:通常是给予疾病模型动物已知应 该有效的药物或者其他有效因素的处理;目的 是对比某受试药物与阳性药物对比,是否有效; 举例:已知阿霉素对乳腺癌肿瘤生长有抑制作 用,因此我们可以选用阿霉素作为阳性对照, 来判断此受试药物的治疗效果。
问题二: 每组几只合适?
动物实验设计应遵循实行“3R原则”,包括实验 动物的替代、减少和优化原则,其中减少即指 尽量减少实验动物的数量。查阅文献,并未发 现对实验动物数目有绝对要求,但在减少的同 时,一定要满足统计学要求。统计学上要求一 般至少每组有6个可用数据,才有意义。
[2] Festing M F, Altman D G. Guidelines for the Design and Statistical Analysis of Experiments Using Laboratory Animals[J]. Ilar Journal, 2002, 43(4): 244-258.
一般小鼠的每组一般不少于10只; 一般大鼠每组不少于6只; 大动物等级越高,价格越贵,根据情况可适当
减少,但一般不能少于4-5只。
问题三: 如何进行随机分配?
根本不同的实验目的,实验对象,分组时常用的 方法有:完全随机设计、随机区组设计等[3-4]。 实现随机分组时需要利用随机数字表以及随机数 余数分组法。
优势:区间分组将保证了实验组间的生物差异减到了 最小,遵循了一致性原则与随机性原则,使实验结果 更具有统计学意义。
注:有时候我们会碰到多个因素,则需要依次分区, 如:40只体重差异较大的小鼠,雌雄不一,此时我们 不能只按照体重区组分配,需要先把雌雄分开,然后 各自按体重分层。即它要求随机先按某一因素分成相 等的几组,再在组内按另一因素分成几个区。
人工智能辅助的药物设计
内存峰值 (GB)
3000
TB
2500
2000
1500
1000
GB
500
0
0
2000 4000 6000 8000
序列长度 (aa)
越低越好
w/o TPP w/ TPP 多项式 (w/o TPP) 线性 (w/ TPP)
预测的蛋白结构
内存占用量级
预测的蛋白结构示例
单卡GPU是最优选择
~20GB
~40GB
ICX6330
ICX6330
SPR9462
谢谢!
人工智能辅助的药物设计
内容总览
1. 市场挑战及突破口 2. 大分子药物设计代表场景的优化 3. 小分子药物设计代表场景的优化
Al药物设计的场景和挑战
大分子药物设计
A. Anishchico et al. Nature 2021
基础研究的工具分子
Hallucination AfDesign trRosetta
基线 + icc
…
使用英特尔 C++ 编译器 配置 jemalloc
基线 + icc + AVX512
…
使用英特尔 AVX-512 指令集 优化MSA热点函数
基线 + icc + AVX512 + 并 行MSA
Parallel MSA
…
并行处理 MSA 搜索
1.97
1.00 Baseline
1.25 Intel C++ Compiler + jemalloc
xB
64GB
HBM2e
up to
112.5MB
guidelines-omcl-computerised-systems-annex1-march2018中英
General European OMCL Network (GEON) QUALITY MANAGEMENT DOCUMENTPA/PH/OMCL (08) 87 R6VALIDATION OF COMPUTERISED SYSTEMS ANNEX 1 – VALIDATION OF EXCEL SPREADSHEETSFull document titleand reference Validation of Computerised SystemsAnnex 1 – Validation of Excel Spreadsheets PA/PH/OMCL (08) 87 R6 Document type Guideline Legislative basis - Date of first adoption May 2009 Date of original entry into forceJuly 2009 Date of entry into force of revised documentAugust 2018Previous titles/other references / last valid version Validation of Computerised SystemsAnnex 1: Validation of computerised calculation systems: example of validation of in-house softwarePA/PH/OMCL (08) 87 2R Custodian Organisation The present document was elaborated by the OMCL Network / EDQM of the Council of Europe Concerned NetworkGEONPA/PH/OMCL(08)87R6–Annex1of the OMCL Network Guideline“Validation of Computerised Systems”Validation of Excel SpreadsheetsANNEX 1 OF THE OMCL NETWORK GUIDELINE“VALIDATION OF COMPUTERISED SYSTEMS”VALIDATION OF EXCEL SPREADSHEETSNote: Mandatory requirements in this guideline and its annexes are defined using the terms«shall» or «must». The use of «should» indicates a recommendation. For these parts of the text other appropriately justified approaches are acceptable. The term «can» indicates a possibility or an example with non-binding character.1. INTRODUCTIONThis is the 1st Annex of the core document “Validation of Computerised Systems”, and it should be used in combination with the latter when planning, performing and documenting the validation process of Excel® spreadsheets used for the processing of laboratory data.This Annex presents an example of Excel spreadsheet validation, which should be used in combination with the general requirements and recommendations given in the core document.2. INSTALLATION AND SECURITYTo guarantee that only the latest validated version of the spreadsheet is being used and to maintain the validated state of the spreadsheet, all validated Excel spreadsheets should be stored with read- only access rights for the end users (e.g., on a protected network share). Only responsible persons should have write access to the network share.为确保只有经验证过的Excel表被使用且一直维持其验证状态,所有被验证的Excel表的终端用户应该只有只读权限(比如:受保护的网络共享)。
acmg指南中英文对照
acmg指南中英文对照ACMG guidelines are excellent resources for healthcare professionals. It provides a comprehensive framework for the evaluation and management of genetic conditions. The guidelines cover a wide array of topics, ranging from interpretation of genetic testing results to counseling patients about their risks. These guidelines are instrumental in ensuring that individuals receive the most accurate and up-to-date information about their genetic health.ACMG指南是医疗保健专业人员的优秀资源。
它提供了一个全面的框架,用于评估和管理遗传疾病。
这些指南涵盖了广泛的主题,从基因测试结果的解释到向患者提供有关其风险的咨询。
这些指南在确保个体获得关于其遗传健康的最准确和最新信息方面起着至关重要的作用。
One key aspect of the ACMG guidelines is the emphasis on informed decision-making and patient autonomy. Healthcare providers are encouraged to involve patients in the decision-making process and respect their preferences. This patient-centered approach fosters trust and collaboration between healthcare professionals and their patients. By empowering individuals to make informed choices abouttheir genetic health, the guidelines promote good communication and shared decision-making.ACMG指南的一个关键方面是强调知情决策和患者自主权。
triplot 1.3.0 用户手册说明书
Package‘triplot’October14,2022Title Explaining Correlated Features in Machine Learning ModelsVersion1.3.0Description Tools for exploring effects of correlated features in predictive models.The predict_triplot()function delivers instance-level explanationsthat calculate the importance of the groups of explanatory variables.Themodel_triplot()function delivers data-level explanations.The generic plotfunction visualises in a concise way importance of hierarchical groups ofpredictors.All of the the tools are model agnostic,therefore works for anypredictive machine learning models.Find more details in Biecek(2018)<arXiv:1806.08915>.Depends R(>=3.6)License GPL-3Encoding UTF-8LazyData trueRoxygenNote7.1.1Imports ggplot2,DALEX(>=1.3),glmnet,ggdendro,patchworkSuggests testthat,knitr,randomForest,mlbench,ranger,gbm,covrURL https:///ModelOriented/triplotBugReports https:///ModelOriented/triplot/issues Language en-USNeedsCompilation noAuthor Katarzyna Pekala[aut,cre],Przemyslaw Biecek[aut](<https:///0000-0001-8423-1823>) Maintainer Katarzyna Pekala<**************************>Repository CRANDate/Publication2020-07-1317:00:03UTC1R topics documented:aspect_importance (2)aspect_importance_single (4)calculate_triplot (6)cluster_variables (8)get_sample (9)group_variables (10)hierarchical_importance (10)list_variables (12)plot.aspect_importance (13)plot.cluster_variables (14)plot.triplot (15)print.aspect_importance (16)Index18aspect_importance Calculates importance of variable groups(called aspects)for a se-lected observationDescriptionPredict aspects function takes a sample from a given dataset and modifies it.Modification is made by replacing part of its aspects by values from the observation.Then function is calculating the difference between the prediction made on modified sample and the original sample.Finally,it measures the impact of aspects on the change of prediction by using the linear model or lasso.Usageaspect_importance(x,...)##S3method for class explaineraspect_importance(x,new_observation,variable_groups,N=1000,n_var=0,sample_method="default",f=2,...)##Default S3method:aspect_importance(x,data,predict_function=predict,label=class(x)[1],new_observation,variable_groups,N=100,n_var=0,sample_method="default",f=2,...)lime(x,...)predict_aspects(x,...)Argumentsx an explainer created with the DALEX::explain()function or a model to be ex-plained....other parametersnew_observationselected observation with columns that corresponds to variables used in themodelvariable_groupslist containing grouping of features into aspectsN number of observations to be sampled(with replacement)from data NOTE: Small N may cause unstable results.n_var maximum number of non-zero coefficients after lassofitting,if zero than linear regression is usedsample_method sampling method in get_samplef frequency in get_sampledata dataset,it will be extracted from x if it’s an explainer NOTE:It is best when target variable is not present in the datapredict_functionpredict function,it will be extracted from x if it’s an explainer label name of the model.By default it’s extracted from the’class’attribute of the model.ValueAn object of the class aspect_importance.Contains data frame that describes aspects’impor-tance.Exampleslibrary("DALEX")model_titanic_glm<-glm(survived==1~class+gender+age+sibsp+parch+fare+embarked,data=titanic_imputed,family="binomial")explain_titanic_glm<-explain(model_titanic_glm,data=titanic_imputed[,-8],y=titanic_imputed$survived==1,verbose=FALSE)aspects<-list(wealth=c("class","fare"),family=c("sibsp","parch"),personal=c("gender","age"),embarked="embarked")predict_aspects(explain_titanic_glm,new_observation=titanic_imputed[1,],variable_groups=aspects)library("randomForest")library("DALEX")model_titanic_rf<-randomForest(factor(survived)~class+gender+age+sibsp+parch+fare+embarked,data=titanic_imputed)explain_titanic_rf<-explain(model_titanic_rf,data=titanic_imputed[,-8],y=titanic_imputed$survived==1,verbose=FALSE)predict_aspects(explain_titanic_rf,new_observation=titanic_imputed[1,],variable_groups=aspects)aspect_importance_singleAspects importance for single aspectsDescriptionCalculates aspect_importance for single aspects(every aspect contains only one feature). Usageaspect_importance_single(x,...)##S3method for class explaineraspect_importance_single(x,new_observation,N=1000,n_var=0,sample_method="default",f=2,...)##Default S3method:aspect_importance_single(x,data,predict_function=predict,label=class(x)[1],new_observation,N=1000,n_var=0,sample_method="default",f=2,...)Argumentsx an explainer created with the DALEX::explain()function or a model to be ex-plained....other parametersnew_observationselected observation with columns that corresponds to variables used in themodel,should be without target variableN number of observations to be sampled(with replacement)from data NOTE: Small N may cause unstable results.n_var how many non-zero coefficients for lassofitting,if zero than linear regression is usedsample_method sampling method in get_samplef frequency in in get_sampledata dataset,it will be extracted from x if it’s an explainer NOTE:Target variable shouldn’t be present in the datapredict_functionpredict function,it will be extracted from x if it’s an explainer label name of the model.By default it’s extracted from the’class’attribute of the model.ValueAn object of the class’aspect_importance’.Contains dataframe that describes aspects’importance.Exampleslibrary("DALEX")model_titanic_glm<-glm(survived==1~class+gender+age+sibsp+parch+fare+embarked,data=titanic_imputed,family="binomial")explainer_titanic<-explain(model_titanic_glm,data=titanic_imputed[,-8],verbose=FALSE)aspect_importance_single(explainer_titanic,new_observation=titanic_imputed[1,-8])calculate_triplot Calculate triplot that sums up automatic aspect/feature importancegroupingDescriptionThis function shows:•plot for the importance of single variables,•tree that shows importance for every newly expanded group of variables,•clustering tree.Usagecalculate_triplot(x,...)##S3method for class explainercalculate_triplot(x,type=c("predict","model"),new_observation=NULL,N=1000,loss_function=DALEX::loss_root_mean_square,B=10,fi_type=c("raw","ratio","difference"),clust_method="complete",cor_method="spearman",...)##Default S3method:calculate_triplot(x,data,y=NULL,predict_function=predict,label=class(x)[1],type=c("predict","model"),new_observation=NULL,N=1000,loss_function=DALEX::loss_root_mean_square,B=10,fi_type=c("raw","ratio","difference"),clust_method="complete",cor_method="spearman",...)##S3method for class triplotprint(x,...)model_triplot(x,...)predict_triplot(x,...)Argumentsx an explainer created with the DALEX::explain()function or a model to be ex-plained....other parameterstype if predict then aspect_importance is used,if model than feature_importance iscalculatednew_observationselected observation with columns that corresponds to variables used in themodel,should be without target variableN number of rows to be sampled from data NOTE:Small N may cause unstableresults.loss_function a function that will be used to assess variable importance,if type=modelB integer,number of permutation rounds to perform on each variable in featureimportance calculation,if type=modelfi_type character,type of transformation that should be applied for dropout loss,if type=model."raw"results raw drop losses,"ratio"returns drop_loss/drop_loss_full_model.clust_method the agglomeration method to be used,see hclust methodscor_method the correlation method to be used see cor methodsdata dataset,it will be extracted from x if it’s an explainer NOTE:Target variableshouldn’t be present in the data8cluster_variables y true labels for data,will be extracted from x if it’s an explainerpredict_functionpredict function,it will be extracted from x if it’s an explainer label name of the model.By default it’s extracted from the’class’attribute of the model.Valuetriplot objectExampleslibrary(DALEX)set.seed(123)apartments_num<-apartments[,unlist(lapply(apartments,is.numeric))]apartments_num_lm_model<-lm(m2.price~.,data=apartments_num)apartments_num_new_observation<-apartments_num[30,]explainer_apartments<-explain(model=apartments_num_lm_model,data=apartments_num[,-1],y=apartments_num[,1],verbose=FALSE)apartments_tri<-calculate_triplot(x=explainer_apartments,new_observation=apartments_num_new_observation[-1]) apartments_tricluster_variables Creates a cluster tree from numeric featuresDescriptionCreates a cluster tree from numeric features and their correlations.Usagecluster_variables(x,...)##Default S3method:cluster_variables(x,clust_method="complete",cor_method="spearman",...) Argumentsx dataframe with only numeric columns...other parametersclust_method the agglomeration method to be used see hclust methodscor_method the correlation method to be used see cor methodsget_sample9 Valuean hclust objectExampleslibrary("DALEX")dragons_data<-dragons[,c(2,3,4,7,8)]cluster_variables(dragons_data,clust_method="complete")get_sample Function for getting binary matrixDescriptionFunction creates binary matrix,to be used in aspect_importance method.It starts with a zero matrix.Then it replaces some zeros with ones.If sample_method="default"it randomly replaces one or two zeros per row.If sample_method="binom"it replaces random number of zeros per row-average number of replaced zeros can be controlled by parameter sample_method="f".Function doesn’t allow the returned matrix to have rows with only zeros.Usageget_sample(n,p,sample_method=c("default","binom"),f=2)Argumentsn number of rowsp number of columnssample_method sampling methodf frequency for binomial samplingValuea binary matrixExamplesget_sample(100,6,"binom",3)10hierarchical_importancegroup_variables Helper function that combines clustering variables and creating as-pect listDescriptionDivides correlated features into groups,called aspects.Division is based on correlation cutoff level. Usagegroup_variables(x,h,clust_method="complete",cor_method="spearman") Argumentsx hclust objecth correlation value for tree cuttingclust_method the agglomeration method to be used see hclust methodscor_method the correlation method to be used see cor methodsValuelist with aspectExampleslibrary("DALEX")dragons_data<-dragons[,c(2,3,4,7,8)]group_variables(dragons_data,h=0.5,clust_method="complete")hierarchical_importanceCalculates importance of hierarchically grouped aspectsDescriptionThis function creates a tree that shows order of feature grouping and calculates importance of every newly created aspect.hierarchical_importance11Usagehierarchical_importance(x,data,y=NULL,predict_function=predict,type="predict",new_observation=NULL,N=1000,loss_function=DALEX::loss_root_mean_square,B=10,fi_type=c("raw","ratio","difference"),clust_method="complete",cor_method="spearman",...)##S3method for class hierarchical_importanceplot(x,absolute_value=FALSE,show_labels=TRUE,add_last_group=TRUE,axis_lab_size=10,text_size=3,...)Argumentsx a model to be explained.data dataset NOTE:Target variable shouldn’t be present in the datay true labels for datapredict_functionpredict functiontype if predict then aspect_importance is used,if model than feature_importance is calculatednew_observationselected observation with columns that corresponds to variables used in themodel,should be without target variableN number of rows to be sampled from data NOTE:Small N may cause unstable results.loss_function a function that will be used to assess variable importance,if type=modelB integer,number of permutation rounds to perform on each variable in featureimportance calculation,if type=model12list_variables fi_type character,type of transformation that should be applied for dropout loss,if type=model."raw"results raw drop losses,"ratio"returns drop_loss/drop_loss_full_model.clust_method the agglomeration method to be used,see hclust methodscor_method the correlation method to be used see cor methods...other parametersabsolute_value if TRUE,aspects importance values will be drawn as absolute valuesshow_labels if TRUE,plot will have annotated axis Yadd_last_group if TRUE,plot will draw connecting line between last two groupsaxis_lab_size size of labels on axis Y,if applicabletext_size size of labels annotating values of aspects importanceValueggplotExampleslibrary(DALEX)apartments_num<-apartments[,unlist(lapply(apartments,is.numeric))]apartments_num_lm_model<-lm(m2.price~.,data=apartments_num)hi<-hierarchical_importance(x=apartments_num_lm_model,data=apartments_num[,-1],y=apartments_num[,1],type="model")plot(hi,add_last_group=TRUE,absolute_value=TRUE)list_variables Cuts tree at custom height and returns a listDescriptionThis function creates aspect list after cutting a cluster tree of features at a given height.Usagelist_variables(x,h)Argumentsx hclust objecth correlation value for tree cuttingValuelist of aspectsplot.aspect_importance13Exampleslibrary("DALEX")dragons_data<-dragons[,c(2,3,4,7,8)]cv<-cluster_variables(dragons_data,clust_method="complete")list_variables(cv,h=0.5)plot.aspect_importanceFunction for plotting aspect_importance resultsDescriptionThis function plots the results of aspect_importance.Usage##S3method for class aspect_importanceplot(x,...,bar_width=10,show_features=aspects_on_axis,aspects_on_axis=TRUE,add_importance=FALSE,digits_to_round=2,text_size=3)Argumentsx object of aspect_importance class...other parametersbar_width bar widthshow_features if TRUE,labels on axis Y show aspect names,otherwise they show features namesaspects_on_axisalias for show_features held for backwards compatibility add_importance if TRUE,plot is annotated with values of aspects importancedigits_to_roundinteger indicating the number of decimal places used for rounding values ofaspects importance shown on the plottext_size size of labels annotating values of aspects importance,if applicable14plot.cluster_variablesValuea ggplot2objectExampleslibrary("DALEX")model_titanic_glm<-glm(survived==1~class+gender+age+sibsp+parch+fare+embarked,data=titanic_imputed,family="binomial")explain_titanic_glm<-explain(model_titanic_glm,data=titanic_imputed[,-8],y=titanic_imputed$survived==1,verbose=FALSE)aspects<-list(wealth=c("class","fare"),family=c("sibsp","parch"),personal=c("gender","age"),embarked="embarked")titanic_ai<-predict_aspects(explain_titanic_glm,new_observation=titanic_imputed[1,],variable_groups=aspects)plot(titanic_ai)plot.cluster_variablesPlots tree with correlation valuesDescriptionPlots tree that illustrates the results of cluster_variables function.Usage##S3method for class cluster_variablesplot(x,p=NULL,show_labels=TRUE,axis_lab_size=10,text_size=3,...) Argumentsx cluster_variables or hclust objectp correlation value for cutoff level,if not NULL,cutoff line will be drawnshow_labels if TRUE,plot will have annotated axis Yaxis_lab_size size of labels on axis Y,if applicabletext_size size of labels annotating values of correlations...other parametersplot.triplot15ValueplotExampleslibrary("DALEX")dragons_data<-dragons[,c(2,3,4,7,8)]cv<-cluster_variables(dragons_data,clust_method="complete")plot(cv,p=0.7)plot.triplot Plots triplotDescriptionPlots triplot that sum up automatic aspect/feature importance groupingUsage##S3method for class triplotplot(x,absolute_value=FALSE,add_importance_labels=FALSE,show_model_label=FALSE,abbrev_labels=0,add_last_group=TRUE,axis_lab_size=10,text_size=3,bar_width=5,margin_mid=0.3,...)Argumentsx triplot objectabsolute_value if TRUE,aspect importance values will be drawn as absolute valuesadd_importance_labelsif TRUE,first plot is annotated with values of aspects importance on the bars show_model_labelif TRUE,adds subtitle with model labelabbrev_labels if greater than0,labels for axis Y in single aspect importance plot will be ab-breviated according to this parameteradd_last_group if TRUE and type=predict,plot will draw connecting line between last two groups at the level of105biggest importance value,for model this line is alwaysdrawn at the baseline valueaxis_lab_size size of labels on axistext_size size of labels annotating values of aspects importance and correlationsbar_width bar width in thefirst plotmargin_mid size of a right margin of a middle plot...other parametersValueplotExampleslibrary(DALEX)set.seed(123)apartments_num<-apartments[,unlist(lapply(apartments,is.numeric))]apartments_num_lm_model<-lm(m2.price~.,data=apartments_num)apartments_num_new_observation<-apartments_num[30,]explainer_apartments<-explain(model=apartments_num_lm_model,data=apartments_num[,-1],y=apartments_num[,1],verbose=FALSE)apartments_tri<-calculate_triplot(x=explainer_apartments,new_observation=apartments_num_new_observation[-1])plot(apartments_tri)print.aspect_importanceFunction for printing aspect_importance resultsDescriptionThis function prints the results of aspect_importance.Usage##S3method for class aspect_importanceprint(x,show_features=FALSE,show_corr=FALSE,...)Argumentsx object of aspect_importance classshow_features show list of features for every aspectshow_corr show if all features in aspect are pairwise positively correlated(for numeric features only)...other parametersExampleslibrary("DALEX")model_titanic_glm<-glm(survived==1~class+gender+age+sibsp+parch+fare+embarked,data=titanic_imputed,family="binomial")explain_titanic_glm<-explain(model_titanic_glm,data=titanic_imputed[,-8],y=titanic_imputed$survived==1,verbose=FALSE)aspects<-list(wealth=c("class","fare"),family=c("sibsp","parch"),personal=c("gender","age"),embarked="embarked")titanic_ai<-predict_aspects(explain_titanic_glm,new_observation=titanic_imputed[1,],variable_groups=aspects)print(titanic_ai)Indexaspect_importance,2aspect_importance_single,4calculate_triplot,6cluster_variables,8cor,7,8,10,12get_sample,3,5,9group_variables,10hclust,7,8,10,12hierarchical_importance,10lime(aspect_importance),2list_variables,12model_triplot(calculate_triplot),6plot.aspect_importance,13plot.cluster_variables,14plot.hierarchical_importance(hierarchical_importance),10 plot.triplot,15predict_aspects(aspect_importance),2 predict_triplot(calculate_triplot),6 print.aspect_importance,16print.triplot(calculate_triplot),618。
acmg指南英文版
acmg指南英文版## English Response.ACMG Guidelines for the Interpretation and Reporting of Sequence Variants.The American College of Medical Genetics and Genomics (ACMG) has developed guidelines to assist clinicians and laboratory professionals in the interpretation andreporting of sequence variants. These guidelines are based on the latest scientific evidence and are designed to ensure that patients receive accurate and consistent information about their genetic test results.The ACMG guidelines use a five-tiered system toclassify sequence variants:Pathogenic: A variant that is known to cause disease.Likely pathogenic: A variant that is likely to causedisease, but additional evidence is needed to confirm pathogenicity.Variant of uncertain significance (VUS): A variantthat cannot be classified as pathogenic or benign.Likely benign: A variant that is likely to be benign, but additional evidence is needed to confirm benignity.Benign: A variant that is known to be benign.The ACMG guidelines also provide specific criteria for classifying variants into each of these categories. These criteria include:Population frequency: The frequency of the variant in the general population.Functional impact: The predicted impact of the variant on the function of the gene.Computational predictions: The predictions ofcomputational algorithms that can assess the pathogenicity of variants.Segregation data: The pattern of inheritance of the variant in a family.Other available evidence: Any other information that can help to classify the variant, such as animal models or functional studies.The ACMG guidelines are a valuable tool for clinicians and laboratory professionals who are interpreting and reporting sequence variants. By using these guidelines, clinicians can ensure that patients receive accurate and consistent information about their genetic test results.## Chinese Response.ACMG序列变异解读和报告指南。
海王星 R-27 船用柴油发动机用户手册说明书
Quality Craftsmanship Since 1958TABLE OF CONTENTSTable Of Contents (2)Congratulations (3)Safety (3)Symbol Glossary (4)Specifications (Subject To Change Without Notice) (5)Equipment Location (6)Starboard Fittings (6)Port Fittings (7)Stern Components (8)Main Cabin And Cockpit Lights (9)Fuel System, Engine, Generator (10)Raw Water / Sea Strainer System (11)Fresh Water Plumbing System (12)Shower Sump (13)Bilge Pump System (14)Waste System With Macerator Pump (15)Air Conditioning (16)Webasto Furnace (17)Solar Panel (18)Battery Configuration (19)Fuse Location & Values (20)Fuse Location & Values (21)Ac Distribution Panel & Rotary Switch (22)12V Helm Control Operation (23)Ranger Tug R-27 Wiring Schematic (Acc. 1) (24)Ranger Tug R-27 Wiring Schematic (Acc. 2) (25)Ranger Tug R-27 Wiring Schematic (Acc. 3) (26)Ranger Tug R-27 Wiring Schematic (Lighting) (27)Ranger Tug R-27 Wiring Schematic (P.D.P.) (28)Ranger Tug R-27 Working Deck (29)Care And Maintenance (30)Example Of A Preparation For The Road Checklist (30)Example Of A Spring Pre-Launch Checklist (31)Example Of Winter Storage Checklist (32)Warning Label Locations (33)Contacts (36)CONGRATULATIONSThe Ranger Tug family has a passion for boating. We are committed to continuous process improvement in all areas that affect our customer’s satisfaction with our products and providing great customer service.SAFETYSafety is always a priority at Ranger Tugs. Please read all manuals to ensure that equipment is used in a safe manner. We highly recommend attendance in a Coast Guard approved boating safety course. Such courses are available from the Coast Guard directly or from boating organizations. Owners should have annual inspec-tions to ensure that all safety equipment is current.SYMBOL GLOSSARYSTE OPT Attention! – Important Operating or Maintenance Instructions Attention! – Electrical Shock HazardFresh WaterBlack WaterFuelStandard EquipmentOptional EquipmentHintsSPECIFICATIONS(Subject to Change Without Notice)R-27Length .......................................................................................... 27’ 0” 8.2 m Length Overall – motor up ............................................................ 34’ 6’’ 10.5 m – motor down ....................................................... 32’ 9’’ 10 m Length Overall on Trailer – motor up ............................................. 40’ 7’’ 12.4 m – motor down ........................................ 38’ 8’’ 11.8 m Beam ............................................................................................ 8’ 6” 2.6 m Draft – motor up ........................................................................... 21” .5 m – motor down ...................................................................... 33”.8 m Weight, Dry with motor ................................................................ 7,000 lbs 3,175 kg Water Bridge Clearance (mast down) ............................................ 8’ 1” 2.5 m Height on Trailer (mast down) with radar ...................................... 11’ 5” 3.5 m Fuel Capacity ................................................................................ 150 gal 568 L Water Capacity (fresh) ................................................................... 40 gal 151 L Holding Tank Capacity .................................................................. 30 gal 114 LEQUIPMENT LOCATIONSTARBOARD FITTINGS1 2 3 7 8 11 12 13 14 15 16 17 18 194 5 6 9 10Keep all vents, drains and exhausts clear of any obstructions to ensure proper performance of each system.STE➊ Aft Sink, Cooler Drain &Motor Well Drain➋ Aft Bilge ➌ Center Bilge➍ Compartment Blower/Exhaust ➎ Compartment Blower/Exhaust ➏ Webasto Exhaust (NW Only)➐ Water Tank Vent➑ Waste Tank Vent➒ Webasto Fresh Air Intake (NW Only)➓ AC Exhaust (LE Only)Shower Sump Forward Bilge Head Sink Drain Bow Thruster Anchor RollerWindlass RadarTV Antenna Anchor Light Fuel Fill Water FillTrailering Side Marker Light111312141516171820211922STEPORT FITTINGS1 2 3 4 5 6 7 8 9 1410 11 12 13 15Keep all vents, drains and exhausts clear of any obstructions to ensure proper performance of each system.➊ Anchor Locker Drain ➋ Bow Thruster ➌ Radar➍ TV Antenna ➎ Anchor Light➏ Trailering Side Marker Light ➐ Fuel Vent w/Charcoal Canister➑ Macerator Thru-Hull ➒ Cabin Sink Drain ➓ Diesel Heater FillGenerator Air Intake (LE Only) Generator Exhaust (LE Only) Propane Locker Drain Strainer Relief Overflow11131214STERN COMPONENTSSTE1 2 3 4 5 6 7 8 9 10 11➊ Ski Post➋ Pullout Fresh Water Shower ➌ Fuel Fill➍ Swim Platform Courtesy Light ➎ Trailer Reverse Lights➏ Trailer Running Lights ➐ Trailer Turn/Brake Lights ➑ Cockpit Scupper Drains ➒ Trim Tabs➓ Underwater LightsDrain Plug11MAIN CABIN AND COCKPIT LIGHTSSTEch o n tureSwit fix ht rth In direc t t Sw itchFUEL SYSTEM, ENGINE, GENERATORSTEYamaha 300There is a secondary on-engine fuel filter that is not shown on this drawing. You will be able to find information about this filter in the engine manual supplied with your boat.Pressure Relief Fuel SystemFuel System with Vent FilterPrimary fuel/water seperatorFuel to enginePrimer BulbFuel fill Fuel ventFuel Tank Fuel senderRAW WATER / SEA STRAINER SYSTEM STE• Multi port sea strainer for head and raw water wash down pump.GeneratorMulti StrainerGeneratorStrainer Relief Overflow Thru HullRaw Water WashdownHead Raw WaterMulti StrainerThru-hull/ValveMulti StrainerStrainer Relief Overflow Thru HullRaw Water WashdownMulti StrainerThru-hull/Valve• A/C Raw Water Input• Generator raw water thru-hull strainerR-27 LE R-27 NWFRESH WATER PLUMBING SYSTEMSTE40 Gallon Fresh Water Tank, 5.3 Gallon Hot Water Heater, 3.5 GPM Fresh Water Pump.Disinfecting The Fresh Water SystemTransom showerCockpit sink APPENDIX - POTABLE WATER SYSTEMSThe information contained in this appendix provides supplementary data about disinfecting a potable water system.A SUGGESTED METHOD OF DISINFECTION Perform the following steps in the order indicated: a. Flush entire system thoroughly by allowing potable water to flow through it; b. Drain system completely; c. Fill entire system with a chlorine solution having a strength of at least 100 parts per million, and allow to stand for one (1) hour. Shorter periods will require greater concentrations of chlorine solution. See Table I d. Drain chlorine solution from entire system; e. Flush entire system thoroughly with potable water; f. Fill system with potable water.Table I shows how much disinfecting agent is required to make up various quantities of 100 parts per million chlorine solution.TABLE I – CHLORINE CONCENTRATIONSAmount of chlorine compound required for 100 ppm solutionSolution (Gallons) Chlorinated Lime 25% (ounces) High Test CalciumHypochlorite 70% (ounces) Liquid Sodium Hypochlorite 1% (quarts)50.3 0.1 0.2 10 0.6 0.2 0.4 15 0.9 0.3 0.6 20 1.2 0.4 0.8 30 1.8 0.6 1.2 50 3.0 1.0 2.0 1006.02.04.0NOTE: This table contains information taken from the Handbook on Sanitation of Vessel Water Points, Public Health Service Publication No. 274 - Reprinted June 1963.SHOWER SUMPSTE12V , 800 GPH(This should be inspected for debris on a regular basis if shower is used frequently.)Shower drainThru-hullAft AC condensate drainSump pumpForward Bilge pumpDepth Transducer The shower sump box is located underneath the removable v-berth step positioned just outside the head door.BILGE PUMP SYSTEMCenter bilge pump(1100 GPH)Aft bilge pump (1100 GPH)Through hullThrough hullsBilge pump (900 GPH)STEThe bilge pumps operate automatically by checking for water every 2.5 minutes even with battery switches and breakers in the OFF position.However, the BILGE PUMP and BILGE PUMP2 will run continuously once their switches are placed in the on position. Monitor the outflow accordingly. Do not run when dry.• Manual switches are located at the helm.12V 1100GPH (Aft & Center) 12V 900GPH (Forward)WASTE SYSTEM WITH MACERATOR PUMP30 Gallon Tank with standard pump out, and ventSTEMacerator pump outSTEWaste tank pump out stations are widely available.Please follow the directions carefully for the pump out equipment you are using to avoid damageto the waste system.Boat owner is responsible for following all applicable laws when using the maceratorsystem to pump out into the surrounding waters.Overboard shutoff valve is accessed under the galley sink above the pump area.AIR CONDITIONINGMain Cabin A/C Control Panel (in Mid-Berth)Main Cabin A/C Unit (Under Helm Seat)A/C Raw Water PumpSea StrainerThru Hull/ValveMain Cabin A/C Air Intake Grill (keep uncovered)A/C VentWEBASTO FURNACEWebasto furnace is located under helm seat.The control panel is located at the quarter berth power management center.The fuel pump is beneath the galley sink, inside of the black box.Webasto FurnaceDiesel Tank (5 gal)(behind stove)InteriorHeat Vent (under cup holder)Exhaust(keep unblocked/ gets very warm) Air IntakePump/Filter (beneath galley sink)SOLAR PANELSolar panel 145 watt, with display panel• The solar panel is designed to provide charging to the house & engine batteries. 90% of its charge is dedicated to the house battery and 10% is dedicated to the engine battery.• The green light on the solar display indicates proper operation.• The solar display is located in the mid-berth.• The controller is located in the starboard aft cockpit locker *Keep panel clean and completely uncovered for best resultsSolar PanelDisplayControllerBatteries 112Battery Banks 1 = House 2 = EngineSTEBATTERY CONFIGURATIONSTE2 House Batteries, 1 Engine Battery, 1 Thruster Battery.BatteriesHOUSEENGINEBATTERY PARALLELSTESTEHouse, engine, & battery parallel switches are located in the midberth.Thruster battery switch is located in the port side lazarette Inverter battery switch is located in the port side lazaretteOnce the EMERGENCY PARALLEL switch is placed in the on position the power from the HOUSE batteries will be transferred to the ENGINE battery. Use only for EMERGENCY starting of the engine.If the house bank drops below 10.8v you must reset the charging relay by switching on the parallel while the engine is running or while plugged into shore power.Automatic ChargingRelay (ACR)Automatic ChargingRelay (ACR)Inverter 175 Amp ANLBus Fuse House 300 Amp ANLBus Fuse Thruster 200 Amp ANLBus FuseThruster SwitchInverter SwitchFUSE LOCATION & VALUESSTEThese DC fuse blocks and windlass breaker are located behind a hinged access panel on the star-board side in the head behind the mirror. Fuses are automotive blade type and all values shown below are in Amps.* To reset, reinsert yellow arm“up” into the breaker.To test, press red button and theyellow arm should flip down.LeftRightTrim TabToiletSwitch Panel12v Outlet Bathroom Reading Light Bathroom Light V Berth Light12v OutletSpot LightStereoShower Pump4 SW Panel PowerGPS8 SW Panel Power #28 SW Panel Power #1NEMAAISBildge PumpVHFAuto Pilot40FUSE LOCATION & VALUESSTE These DC fuse blocks are located behind the wood hatch in the midberth. Fuses are automotive blade type and all values shown below are in Amps.Downrigger Starboard Freshwater Switch Downrigger Port TVWashdown SwitchCabin Light LED Light SwitchFridge Foreward Fridge Aft Underwater Lights USB V-Berth USB Port4040CO MonitorStereo Memory Stove Switch#1 Float#2 Float331175This fuse blockis always hotAC DISTRIBUTION PANEL & ROTARY SWITCHSTESTEAC Rotary Selector Switch (Available with Generator) AC Main Line 2 (with AC)The AC Rotary Switch Selector Switch will determine which source of incoming 120 Volt power to use for your AC Distribution Panel.A/C Main 1 and battery charger breaker must on in order for batteries to charge. AC Distribution PanelAC Distribution Panel AC Main 1AC Main 2AC Distribution Panel with GeneratorAC Main 1AC Main 2GENSHORE INVERTER12V HELM CONTROL OPERATIONAt Helm At HelmResettable switchbreakers Resettable switchbreakersSTEArmed = Red light/audible alarm Off = Red light only.The bilge pumps operate automatically with electronic float switches regardless of batteryswitch position.However, the BILGE PUMP and BILGE PUMP2 will run continuously once their switches are placedin the on position. Monitor the outflow accordingly. Do not run when dry.NAVLTSCHARTLTSAFT BILGEFWD BILGEBOW BILGEMACE RATORFAN ACCYWIPER HORN WNDLS WIPERRANGER TUG R-27 WIRING SCHEMATIC (ACC. 1)R-27 Accessories 1+12VELECTRICAL SCHEMATIC-12VRANGER TUG R-27 WIRING SCHEMATIC (ACC. 2)R-27 Accessories 2+12VELECTRICAL SCHEMATIC-12VRANGER TUG R-27 WIRING SCHEMATIC (ACC. 3)R-27 Accessories 3+12VELECTRICAL SCHEMATIC Breaker FuseHorn Prompt toSwitch DPST-12VRANGER TUG R-27 WIRING SCHEMATIC (LIGHTING)+12VR-27 LightingELECTRICAL SCHEMATIC-12VRANGER TUG R-27 WIRING SCHEMATIC (P.D.P.)Battery Battery Battery Battery3211RANGER TUG R-27 WORKING DECKSTECARE AND MAINTENANCEPlease customize to your personal needs. Consult your engine and trailer user manuals for ad-ditional information.EXAMPLE OF A PREPARATION FOR THE ROAD CHECKLISTTOW VEHICLE – PRIOR TO USE£ Test Lights.£ Check brakes.£ Check tire pressure and condition.£ Check hitch related electrical connections.TRAILER – PRIOR TO USE£ Check registration£ Check rollers and bed rails.£ Check wheel bearings and lubricate as required.£ Check winch.£ Test electrical connection and lights.£ Check tire pressure and condition.£ Check safety chains.£ Check boat straps.£ Check braking system.£ Check hitch for proper connection and lock down.£ Install safety chains (cross under hitch).£ Remove tire blocks.BOAT – PRIOR TO USE WITH TRAILER£ Lower mast.£ Lower VHF antenna.£ Secure the Bimini awning frame.£ Raise and secure swim platform ladder.£ Set all switches and breakers to the OFF position, Including Thruster/Windlass cutoff switch£ Close and secure all windows, ports and vents.£ Clear countertops.£ Lock fridge latch.£ Check engine is up!£ Lock cabin.£ Remove Drain PlugEXAMPLE OF A SPRING PRE-LAUNCH CHECKLISTCLEANING£ Remove debris from scuppers and scupper drains.£ Clean hull using a mild biodegradable detergent and then wax.£ Clean topsides and decks using a mild biodegradable detergent and then wax.£ Clean and polish all bright work.£ Clean and oil teak.£ Clean windows, ports, and hatches.£ Clean bimini cover.£ Check and clean anchor, rode, and anchor storage compartment.INSPECTION£ Check Drain Plug£ Check spare parts and tools and replace as necessary.£ Check wiper blades.£ Check swim platform.£ Inspect and test trim tabs.£ Check condition of bottom paint.£ Check windlass.£ Verify electronics for correct operation.£ Check all inside and outside lights.£ Macerator Valve in proper position and secured.£ Inspect and verify position of all sea cocks and shut off valves.£ Check alarms for proper operation.£ Check fluid levels.SAFETY EQUIPMENT£ Sound signaling device.£ Check flares and their expiration dates.£ Check personal flotation devices/throw cusions.£ Check fire extinguishers and their fill dates.£ Boat hook.£ Lines/fenders.£ First aid kits.GALLEY£ Check stove for proper operation.£ Check everyday utensil stock.DOCUMENTS£ Registration sticker.£ Insurance papers and Passports.£ Boat Inspection sticker.£ Charts and float plan forms.EXAMPLE OF WINTER STORAGE CHECKLISTGENERAL MAINTENANCE£ Fill Fuel Tank and add a fuel stabilizer.£ Empty and clean black water tank.£ Empty fresh water tank use a non-toxic antifreeze per manufacturer’s directions, or remove all water from the system.£ Winterize black and fresh water tanks as necessary based on weather.£ Check bilge area for oil and for proper operation£ Check zincs and replace as necessary.£ Check and clean water strainer.£ Clear barnacles and debris from hull fittings.£ Trickle charge batteries every 30-60 days.£ Vent boat to prevent mildew.£ Check trailer tire pressure and condition.£ Check trailer braking system.£ Check trailer bearings.£ Remove Drain Plug.£ Turn off all battery cutoff switches.ENGINE£ Flush engine(s) with fresh water.£ Check all fluid levels.£ Check all hose fittings.£ Check impeller.£ Check engine maintenance requirements.GALLEY£ Empty, clean and freshen refrigerator.£ Remove all dry food from storage.WARNING LABEL LOCATIONSNOTESNOTESFax 253-839-5218 。
ICH Q3D_中英_step 4 最新版
G UIDELINE FOR E LEMENTALIMPURITIES元素杂质指南TABLE OFCONTENTS目录1. I NTRODUCTION 简介2. S COPE 范围3. S AFETY A SSESSMENT OF P OTENTIAL E LEMENTAL I MPURITIES 潜在元素杂质的安全性评估3.1 Principles of the Safety Assessment of Elemental Impurities for Oral, Parenteral and InhalationRoutes of Administration口服、注射和吸入给药途径的元素杂质安全性评估规则3.2 Other Routes of Administration 其他给药途径3.3 Justification for Elemental Impurity Levels Higher than an Established PDE元素杂质水平高于已建立的PDE阈值的合理性说明3.4 Parenteral Products 注射用药4. E LEMENT C LASSIFICATION 元素分类5. R ISK A SSESSMENT AND C ONTROL OF E LEMENTAL I MPURITIES 元素杂质的风险评估和控制5.1 General Principles 通用准则5.2 Potential Sources of Elemental Impurities 元素杂质潜在的来源5.3 Identification of Potential Elemental Impurities 潜在元素杂质的识别5.4 Recommendations for Elements to be Considered in the Risk Assessment建议在风险评估中考虑的元素5.5 Evaluation 评估5.6 Summary of Risk Assessment Process 风险评估总结5.7 Special Considerations for Biotechnologically-Derived Products 生物技术衍生产品的特殊考虑6. C ONTROL OF E LEMENTAL I MPURITIES 元素杂质控制7. C ONVERTING B ETWEEN PDE S AND C ONCENTRATION L IMITS PDE值和浓度限的相互转换8. S PECIATION AND O THER C ONSIDERATIONS 元素形态和其他考虑9. A NALYTICAL P ROCEDURES 分析方法10. L IFECYCLE M ANAGEMENT 生命周期管理G UIDELINE FOR E LEMENTAL I MPURITIES元素杂质指南 Q3DQ3D1. I NTRODUCTION 简介Elemental impurities in drug products may arise from several sources; they may be residual catalysts that were added intentionally in synthesis or may be present as impurities (e.g., through interactions with processing equipment or container/closure systems or by being present in components of the drug product). Because elemental impurities do not provide any therapeutic benefit to the patient, their levels in the drug product should be controlled within acceptable limits. There are three parts of this guideline: the evaluation of the toxicity data for potential elemental impurities; the establishment of a Permitted Daily Exposure (PDE) for each element of toxicological concern; and application of a risk- based approach to control elemental impurities in drug products. An applicant is not expected to tighten the limits based on process capability, provided that the elemental impurities in drug products do not exceed the PDEs. The PDEs established in this guideline are considered to be protective of public health for all patient populations. In some cases, lower levels of elemental impurities may be warranted when levels below toxicity thresholds have been shown to have an impact on other quality attributes of the drug product (e.g., element catalyzed degradation of drug substances). In addition, for elements with high PDEs, other limits may have to be considered from a pharmaceutical quality perspective and other guidelines should be consulted (e.g., ICH Q3A).药品中的元素杂质可能有多种来源,可能是合成过程中有意加入的金属催化剂残留或以杂质形式出现(例如,通过与工艺设备或容器/密闭系统的相互反应,或出现在药品成分中)。
特殊英语词汇
ASIC: Applicatio n Specific In tegrated Circuit (特殊应用积体电路)ASC( Auto-Sizi ng and Ce nteri ng ,自动调效屏幕尺寸和中心位置)ASC( Anti Static Coat in gs ,防静电涂层)AGAS( Anti Glare Anti Static Coati ngs ,防强光、防静电涂层)BLA: Bearn Lan di ng Area (电子束落区)BMC( Black Matrix Screen ,超黑矩阵屏幕)CRC: Cyclical Redu nda ncy Check (循环冗余检查)CRT (Cathode Ray Tube,阴极射线管)DDC Display Data Channel ,显示数据通道DEC( Direct Etching Coatings ,表面蚀刻涂层)DFL (Dynamic Focus Lens,动态聚焦)DFS( Digital Flex Scan ,数字伸缩扫描)DIC: Digital Image Co ntrol (数字图像控制)Digital Multisca n II (数字式智能多频追踪)DLP (digital Light Processing ,数字光处理)DOSD: Digital On Scree n Display (同屏数字化显示)DPMS( Display Power Ma nageme nt Sig nalli ng ,显示能源管理信号)Dot Pitch (点距)DQL(Dynamic Quadrapole Lens ,动态四极镜)DSP( Digital Signal Processing ,数字信号处理)EFEAL (Extended Field Elliptical Aperture Lens ,可扩展扫描椭圆孔镜头)FRC: Frame Rate Con trol (帧比率控制)HVD( High Voltage Differential ,高分差动)LCD (liquid crystal display ,液晶显示屏)LCOS: Liquid Crystal On Silico n (硅上液晶)LED (light emitting diode ,光学二级管)L-SAGIC( Low Power-Small Aperture G1 wiht Impregnated Cathode,低电压光圈阴极管)LVD (Low Voltage Differential ,低分差动)LVDS: Low Voltage Differe ntial Sig nal (低电压差动信号)MALS( Multi Astigmatism Lens System ,多重散光聚焦系统)MDA( Monochrome Adapter,单色设备)MS: Mag netic Sen sors (磁场感应器)Porous Tun gste n (活性钨)RSDS: Reduced Swi ng Differe ntial Sig nal (小幅度摆动差动信号)SC (Screen Coatings ,屏幕涂层)Sin gle Ended (单终结)Shadow Mask (阴罩式)TDT (Timeing Detection Table ,数据测定表)TICRG: Tu ngsten Impreg nated Cathode Ray Gun (钨传输阴级射线枪)TFT (thin film transistor ,薄膜晶体管)UCC( Ultra Clear Coatings ,超清晰涂层)VAGP: Variable Aperature Grille Pitch (可变间距光栅)VBI: Vertical Bla nki ng In terval (垂直空白间隙)VDT (Video Display Termi nals ,视频显示终端)VRR: Vertical Refresh Rate (垂直扫描频率)4、视频3D:(Three Dimensional ,三维)3DS (3D SubSystem,三维子系统)AE (Atmospheric Effects ,雾化效果)AFR( Alternate Frame Re nderi ng ,交替渲染技术)Ani sotropic Filteri ng (各向异性过滤)APPE( Advanced Packet Parsing Engine ,增强形帧解析引擎)AV (Analog Video ,模拟视频)Back Buffer,后置缓冲Backface culling (隐面消除)Battle for Eyeballs (眼球大战,各3D图形芯片公司为了争夺用户而作的竞争)Bil in ear Filteri ng (双线性过滤)CEM( cube en vir onment mapp ing ,立方环境映射)CG( Computer Graphics,计算机生成图像)Clipp ing (剪贴纹理)Clock Syn thesizer ,时钟合成器compressed textures (压缩纹理)Con curre nt Comma nd Engine ,协作命令引擎Cen ter Process ingUn it Utilizati on 处理器,中央占用率DAC (Digital to An alog Co nverter ,数模传换器)Decal (印花法,用于生成一些半透明效果,如:鲜血飞溅的场面)DFP( Digital Flat Pan el ,数字式平面显示器)DFS (Dynamic Flat Shading 动态平面描影,可用作加速Dithering 抖动)Directional Light ,方向性光源DME (Direct Memory Execute 直接内存执行)DOF( Depth of Field ,多重境深)dot texture ble ndi ng (点型纹理混和)Double Bufferi ng (双缓冲区)DIR (Direct Rendering Infrastructure ,基层直接渲染)DVI (Digital Video In terface ,数字视频接口)DxR (DynamicXTended Resolution 动态可扩展分辨率)DXTC( Direct X Texture Compress ,DirectX 纹理压缩,以S3TC为基础)Dyn amic Z-bufferi ng (动态Z轴缓冲区),显示物体远近,可用作远景E-DDC (En ha need Display Data Cha nnel ,增强形视频数据通道协议,定义了显示输出与主系统之间的通讯通道,能提高显示输出的画面质量)Edge Anti —aliasing ,边缘抗锯齿失真E-EDID( Enhanced Extended Identification Data ,增强形扩充身份辨识数据,定义了电脑通讯视频主系统的数据格式)Execute Buffers ,执行缓冲区environment mapped bump mapp ing (环境凹凸映射)Extended Burst Transactions ,增强式突发处理Front Buffer ,前置缓冲Flat (平面描影)Frames rate is King (帧数为王)FSAA (Full Scene Anti —aliasi ng ,全景抗锯齿)Fog (雾化效果)flip double buffered (反转双缓存)fog table quality (雾化表画质)GART (Graphic Address Remapp ng Table ,图形地址重绘表)Gouraud Shad ing,高洛德描影,也称为内插法均匀涂色GP(Graphics Processi ng Un it ,图形处理器)GTF (Generalized Timing Formula ,一般程序时间,定义了产生画面所需要的时间,包括了诸如画面刷新率等)HAL (Hardware Abstraction Layer ,硬件抽像化层)hardware moti on compe nsati on (硬件运动补偿)HDTV( high defini tion televisi on ,高清晰度电视)HEL Hardware Emulatio n Layer (硬件模拟层)high tria ngle cou nt (复杂三角形计数)ICD(Installable Client Driver ,可安装客户端驱动程序)IDCT(Inverse Discrete Cosine Transform ,非连续反余弦变换,GeForce 的DVD硬件强化技术)Immediate Mode,直接模式IPPR:(Image Processing and Pattern Recognition 图像处理和模式识别)large textures (大型纹理)LF (Lin ear Filteri ng ,线性过滤,即双线性过滤)lighti ng (光源)lightm ap (光线映射)Local Peripheral Bus (局域边缘总线)mip map pi ng (MIP 映射)Modulate (调制混合)Motion Compensation ,动态补偿motion blur (模糊移动)MPPS (Million Pixels Per Second ,百万个像素/ 秒)Multi-Resolution Mesh ,多重分辨率组合Multi Threaded Bus Master ,多重主控Multitexture (多重纹理)nerest Mipmap (邻近MIP映射,又叫点采样技术)Overdraw (透支,全景渲染造成的浪费)partial texture down loads (并行纹理传输)Parallel Processi ng Perspective Engine (平行透视处理器)PC ( Perspective Correction,透视纠正)PGC ( Parallel Graphics Configuration ,并行图像设置)pixel (Picture eleme nt ,图像元素,又称 P 像素,屏幕上的像素点)poi nt light (一般点光源)point sampling(点采样技术,又叫邻近 MIP 映射)Precise Pixel In terpolation ,精确像素插值 Procedural textures(可编程纹理)RAMD ((Random Access Memory Digital to Analog Converter ,随机存储器数 / 模转换器)Reflection mappi ng (反射贴图)ender (着色或渲染) S 端子(Seperate )S3 ( Sight 、Sou nd 、Speed ,视频、音频、速度)S3TC (S3 Texture Compress , S3纹理压缩,仅支持 S3显卡) S3TL (S3 Transformation & Lighting Scree n Buffer(屏幕缓冲)SDTV ( Sta ndard Defin iti on Television SEM ( spherical environment mapp ingShadi ng ,描影 Si ngle Pass Multi-Texturi ng,单通道多纹理 SLI (Scan li ne In terleave扫描线间插,3Dfx 的双Voodoo 2配合技术)Smart Filter (智能过滤)soft shadows (柔和阴影) soft reflectio ns (柔和反射),S3多边形转换和光源处理),标准清晰度电视),球形环境映射)spot light (小型点光源)SRA( Symmetric Ren deri ng Architecture ,对称渲染架构)Ste ncil Buffers (模板缓冲)Stream Processor (流线处理)SuperScaler Rendering ,超标量渲染TBFB(Tile Based Frame Buffer ,碎片纹理帧缓存)texel (T像素,纹理上的像素点)Texture Fidelity (纹理真实性)texture swapp ing (纹理交换)T&L (Transform and Lighting ,多边形转换与光源处理)T-Buffer (T 缓冲,3dfx Voodoo4 的特效,包括全景反锯齿Full-scene Anti-Aliasing 、动态模糊Motion Blur 、焦点模糊Depth of Field Blur 、柔和阴影Soft Shadows、柔和反射Soft Reflections )TCA (Twin Cache Architecture ,双缓存结构)Tran spare ncy (透明状效果)Tran sformati on (三角形转换)Trili near Filteri ng (三线性过滤)Texture Modes,材质模式TMIPM (Trilinear MIP Mapping 三次线性MIP材质贴图)UMA( Unified Memory Architecture ,统一内存架构)Visualize Geometry Engine ,可视化几何引擎Vertex Lighti ng (顶点光源)Vertical In terpolatio n (垂直调变)VIP (Video In terface Port ,视频接口)ViRGE (Video and Ren deri ng Graphics Engine 视频描写图形引擎)Voxel (Volume pixels ,立体像素,Novalogic 的技术)VQTC( Vector-Qua ntizati on Texture Compressi on,向量纹理压缩)VSIS (Video Signal Standard ,视频信号标准)v-sy nc (同步刷新)Z Buffer (Z 缓存)Data Structures 基本数据结构Diction aries 字典Priority Queues 堆Graph Data Structures 图Set Data Structures 集合Kd-Trees线段树Numerical Problems 数值问题Solvi ng Lin ear Equatio ns 线性方程组Ban dwidth Reduction 带宽压缩Matrix Multiplicatio n 矩阵乘法Determi nants and Perma nents 行歹U式Con stra ined and Uncon stra ined Optimizati on 最值问题Lin ear Programmi ng 线性规戈URa ndom Number Gen eratio n 随机数生成Factoring and Primality Testing 因子分解/ 质数判定Arbitrary Precisi on Arithmetic 高精度计算Knapsack Problem 背包问题Discrete Fourier Transform 离散Fourier 变换Combi natorial Problems 组合问题Sorti ng 排序Search ing 查找Media n and Selectio n 中位数Gen erati ng Permutati ons 排歹U生成Gen erati ng Subsets 子集生成Gen erat ing Partitio ns 划分生成Gen erat ing Graphs 图的生成Cale ndrical Calculati ons 日期Job Scheduli ng 工程安排Satisfiability 可满足性Graph Problems --------- p olynomial 图论-多项式算法Conn ected Comp onents 连通分支Topological Sorting 拓扌卜排序Mi nimum Spa nning Tree 最小生成树Shortest Path 最短路径Tran sitive Closure and Reduct ion 传递闭包Matchi ng 匹配Eulerian Cycle / Chinese Postman Euler 回路/ 中国邮路Edge and Vertex Connectivity 害9边/ 害9点Network Flow 网络流Drawi ng Graphs Nicely 图的描绘Drawi ng Trees 树的描绘Pla narity Detection and Embeddi ng 平面性检测和嵌入Graph Problems -------- hard 图论-NP 问题Clique最大团In depe ndent Set 独立集Vertex Cover 点覆盖Traveli ng Salesma n旅行商问题ProblemHamilt onian Cycle Hamilt on 回路Graph Partiti on 图的划分Vertex Colori ng 点染色Edge Colori ng 边染色Graph Isomorphism 同构Steiner Tree Steiner 树Feedback Edge/Vertex Set 最大无环子图Computati onal Geometry 计算几何Convex Hull 凸包Trian gulati on 三角剖分Voronoi Diagrams Voronoi 图Nearest Neighbor Search 最近点对查询Range Search范围查询Poi nt Locati on 位置查询In tersect ion Detect ion 碰撞测试Bin Packi ng 装箱问题Medial-Axis Tran sformatio n 中轴变换Polygon Partitio ning 多边形分割Simplifyi ng Polygo ns 多边形化简Shape Similarity 相似多边形Motion Pla nning 运动规划Mai ntai ning Li ne Arra ngeme nts 平面分害9Min kowski Sum Min kowski 和Set and Stri ng Problems 集合与串的问题Set Cover 集合覆盖Set Pack ing 集合配置Stri ng Matchi ng 模式匹配Approximate Stri ng Matchi ng 模糊匹配Text Compressi on 压缩Cryptography 密码Fi nite State Machi ne Mi nimizatio n 有穷自动机简化Lon gest Common Substri ng 最长公共子串Shortest Com mon Superstri ng 最短公共父串DP ---- Dyn amic Programmi ng ----- 动态规戈U。
FLEXI-Roll
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Guidelines for Data-Parallel Cycle-Stealing in Networks of Workstations(Extended Abstract)Arnold L.RosenbergDepartment of Computer ScienceUniversity of MassachusettsAmherst,MA01003rsnbrg@AbstractWe derive guidelines for nearly optimally scheduling data-parallel computations within a draconian mode of cycle-stealing in NOWs.In this computing regimen,work-station takes control of workstation’s processor when-ever is idle,with the promise of relinquishing control im-mediately upon demand—thereby losing work in progress. The typically high communication overhead for supplying workstation with work and receiving its results militates in favor of supplying with large amounts of work at a time;the risk of losing work in progress when is re-claimed militates in favor of supplying with a succession of small bundles of work.The challenge is to balance these two pressures in a way that maximizes(some measure of) the amount of work accomplished.Our guidelines attempt to maximize the expected work accomplished by worksta-tion in an episode of cycle-stealing,assuming knowledge of the instantaneous probability of workstation’s being reclaimed.Our study is a step toward rendering prescrip-tive the descriptive study of cycle-stealing in[3].1.The Cycle-Stealing ProblemWe derive guidelines for(almost)optimally schedul-ing data-parallel computations on“borrowed”workstations, within the model developed in[3].The phenomenological study in that paper builds on the following rather draconian version of cycle-stealing—the use by one workstation of idle computing cycles of another.The owner of worksta-tion contracts to take control of workstation whenever its owner is absent.When the owner of reclaims that workstation,workstation immediately relinquishes con-trol of,killing any active job(s)—thereby destroying all work since the last checkpoint.This research was supported in part by NSF Grant CCR-97-10367.Such draconian“contracts”are inevitable,for instance,when a returning owner unplugs a laptop from a net-work;one encounters such contracts also at several in-stitutions where cycle-stealing is supported.Such a“contract”creates a tension between the following inherently conflicting aspects of cycle-stealing.On the one hand,since any work in progress on workstation when it is reclaimed is lost,a cycle-stealer wants to break a cycle-stealing episode into many short periods,supplying small amounts of work to the borrowed workstation each time.On the other hand,since each of the inter-workstation com-munications that bracket every period in a cycle-stealing episode—to supply work to workstation and to reclaim the results of that work—involves an expensive setup pro-tocol,the cycle-stealer wants to break each cycle-stealing episode into a few long periods,supplying large amounts of work to workstation each time.Clearly,the challenge in scheduling episodes of cycle-stealing is to balance these conflicting factors in a way that maximizes the productive output of the episode.The research we report on here re-solves the preceding conflict by deriving scheduling guide-lines that(approximately)maximize the expected work1ac-complished within an episode of cycle-stealing,within the following setting.We focus on computations that are data-parallel,in that they consist of a massive number of inde-pendent repetitive tasks of known durations.Many scientific computations have this form.We develop schedules assuming that we know the instanta-neous probability of workstation’s being reclaimed and that the function yielding this information is“smooth.”Although our results are stated as though we had ex-act knowledge of these probabilities,they extend easilyto situations wherein this knowledge is approximate, 1In a forthcoming sequel,we focus on(nearly)optimizing other mea-sures of a cycle-stealing episode’s work output.1say,garnered from trace data that exposes’s owner’scomputer usage patterns.Our assumption of functional“smoothness”is reasonable,since one would likelyencapsulate even trace data by some“well-behaved”curve.Our hope—and experience—is that the scheduling guide-lines we derive narrow the search space for a truly optimal schedule to manageable proportions.Section2presents the formal model under which we de-rive our scheduling guidelines in Section3.We illustrate the application of the guidelines in a variety of scenarios in Section4and end with open problems in Section5.Other noteworthy studies of scheduling algorithms for NOWs,which differ from ours in focus or objectives,ap-pear in[1,2,4,5,6].Of these,only[2]deals with the present adversarial scenario of stealing cycles;its main con-tribution is a randomized strategy that,with high probabil-ity,steals cycles within a logarithmic factor of optimally. We do not list the many empirical studies of computation on NOWs whose main foci are on enabling systems or specific applications rather than on analyzed scheduling algorithms. Remark.The model we study here has applications to “real-life”problems other than scheduling single episodes of cycle-stealing.One important example is scheduling saves in a fault-prone computing system,as studied in[7]. This problem admits an abstract formulation that is formally similar to our model for cycle-stealing.Our model differs in many details from that of[7],and our research method-ology differs dramatically from that paper’s,but it is clear that our results can be adapted to apply in that setting also.2.Modeling Data-Parallel Cycle-StealingWe review the basic structure of the cycle-stealing model of[3],focusing only on details that are relevant to the cur-rent study.We refer the reader to that paper for additional details and variations on the model presented here.2.1.The ModelOverview.We schedule data-parallel cycle-stealing in an “architecture-independent”fashion,in the sense of[8]:the cost of inter-workstation communications is characterized by a single(overhead)parameter,which is the(combined) cost of initiating both the communication in which worksta-tion sends work to workstation,and the communica-tion in which returns the results of the work.We as-sume that:tasks are indivisible;task times may vary but are known perfectly;the time for a task includes the marginal cost of transmitting its input and output data(so we may keep independent of the sizes of data transmissions). Cycle-stealing schedules.Workstation schedules an episode of cycle-stealing by partitioning the time of’s potential availability into a sequence of nonoverlapping pe-riods.For simplicity,we identify a cycle-stealing sched-ule with its sequence of period-lengths:, where each.A schedule can befinite,when there is aknown upper bound on the length of the episode,or it can be infinite,when no such bound is known.2The intended interpretation is that at timedef ifdef ifthe th period begins:workstation supplies workstation with an amount of work chosen so that time units are sufficient for workstation to send the work to workstation ,for workstation to perform the work,and for worksta-tion to return the results of the work.The work achieved by a schedule.The amount of work achievable in a period of length is3.If workstation is not reclaimed by time,then the amount of work done so far during the episode is augmented by; if is reclaimed by time,then the episode ends,hav-ing accomplished work.(This reckoning re-flects the loss of work from the interrupted period.)Clearly, the risk of having a period interrupted,thereby losing work, may make it desirable to have the lengths of a bounded-lifespan schedule’s productive periods(those with) sum to less than the potential duration of the episode. Cycle-stealing with known risk.One cannot derive prov-ably productive scheduling guidelines without some anti-dote for a malicious adversary who kills every episode of cycle-stealing just at the end of the th period.Here(as in thefirst half of[3]),this antidote resides in our assuming that we know the risk of being interrupted in the midst of a period,in the form of the life function for the episode:for each time,is the probability that workstation has not been reclaimed by time.In accord with the motivating scenario:;when an upper bound to the duration of the episode is known,then decreases monotonically to in the range;when no bound is known,then decreases monotonically for all,with the limit.In or-der to enable our analytical results,we let period-lengths be arbitrary real numbers,and we consider only life functions that are“well-behaved,”in the sense of being differentiable and having noflex points.These idealizations make even our“definitive”results just guidelines.Our goal is to maximize the expected work in an episode of cycle-stealing.For any schedule and life function,this quantity is given bydef(1)2Examples of both situations appear later.3The operator“”denotes positive subtraction and is defined by: def.The summation in(1)has upper limit for an-period schedule and for an infinite schedule(when no duration bound is known).Cycle-stealing schedule is optimal for life function if it maximizes the expected production of work,, over all schedules for.The guidelines we derive emerge from exposing the structure of optimal schedules.2.2.Two Useful Technical ResultsOurfirst result permits us henceforth to use ordinary sub-traction rather than positive subtraction in calculations in-volving(1);it slightly strengthens the analogous result in [3]but follows from the same proof.Proposition1Any schedule for a life function can be replaced by a schedule such that:;each period of—save the last,if isfinite—has length.Our main results presuppose“nice”structure in the life function;all require that be differentiable;some require that enjoy one of the following nice“shapes.”The life function is concave(resp.,convex)ifits derivative is everywhere nonincreasing(resp.,nondecreasing):for all and,we have(resp.,).The three life functions studied in[3]illustrate these prop-erties.The geometrically increasing risk life function with risk factor and potential lifespan,def,is concave.The geometrically decreasing lifespan life function with risk factor,def,is convex.The uniform-risk life function with potential lifes-pan,def,is both concave and convex.Our second result is sometimes useful in sharpening the bounds given by our guidelines for concave life functions. It follows from showing that successive period-lengths of an optimal schedule for a concave life function must decrease by at least,i.e.,that each.Proposition2Every episode of cycle-stealing that has a concave life function hasfinite potential lifespan.An optimal schedule for such a has afinite number of pe-riods,which satisfies(2)3.Our Scheduling GuidelinesOur guidelines for scheduling episodes of cycle-stealing emerge from the bounds in the following theorem,which partially specify the period-lengths of a(nearly)optimal schedule.Theorem1Say that the schedule is optimal for the differentiable life function.(a)The period-lengths of are given implicitly by the in-ductive system of equations:for each period-index,4(3)In computationally more useful form:for each period-index ,(4)(b)If the life function is convex,then(5) If the life function is concave,then(6)Proof Hints.Theorem1(a)follows from the fact that schedule,being optimal,accomplishes at least as much work as does any version of that is“shifted,”in the fol-lowing sense.The-shift,,of and the-shift,,of are the schedulesdefdefwhich have the same number of periods5as andthe same period-lengths,save for period.The lower bounds in Theorem1(b)follow from the fact that an optimal schedule is no less productive than the schedule def that is obtained from by combining thefirst two periods.The upper bounds in Theorem1(b)derive from the fol-lowing lemma.4The upper limit of each summation in(3)is inherited from(1).5That is,if hasfinitely many periods,then andhave the same number;if has infinitely many periods,then so also do and.Lemma1Let be an optimal schedule for life function.Either the initial period-length,or is small enough that(7)The lemma follows from showing that any schedulethat violates condition(7)can be improved(i.e., made more productive)by splitting its th period in two, yielding a schedule of the form def.One now derives the upper bounds in Theorem1(b)by instantiating the system of inequalities that is implicit in(7) with the value,then invoking either the convexity or concavity of the life function.4.Applying the GuidelinesWe illustrate the utility of the guidelines derived in the preceding section,by applying them to some specific life functions,producing for each life function an approxima-tion to the optimal ing system (4),we easily derive explicit expressions for each non-initial period-length,where,in terms of all preceding period-lengths.Of course,these expressions are explicit only modulo ourfinding an explicit expression for.We can only approximate this latter task,by using whichever pair of inequalities(5)or(6)is appropriate for the life func-tion in question.4.1.The Family defWe begin studying a family of concave life functions for an episode of cycle-stealing with potential lifespan;the ()-member of the family is the life function for the uniform risk scenario of[3],wherein the risk of interruption is stable across the opportunity.The non-initial period-lengths.The th period-length of an optimal schedule for can be deter-mined as ing system(4),we deduce thatWhen,this expression simplifies even further,to(8) as was discovered in[3].The initial period-length.Since each is concave,we now invoke pair of inequalities(6)to obtain,after some ma-nipulation,the following bounds on.For specific values of,we can use ad hoc techniques to get even tighter bounds.Most notably,when,we can revisit(3)and the proof of Proposition2,in the light of(8) and the fact that,to deduce that is within additive constants of,as verified in[3].4.2.The Family defThe life functions in this family characterize the geomet-rically decreasing lifespan scenario of[3],which models a cycle-stealing opportunity that has a“half-life.”The non-initial period-lengths.Applying system(4)to ,wefind that the non-initial period-lengths of an optimal schedule satisfy the recurrenceso that(9) Of course,system(9)can be solved for only when eachThe initial period-length.Since each is convex,Lemma 1and the pair of inequalities(5)combine to yield the fol-lowing bounds on.Not unexpectedly,an ad hoc analysis based on the spe-cific value of and the functional form of yields tighter, albeit implicit,bounds;cf.[3].4.3.The Family defThe life functions in this family characterize the geo-metrically increasing risk scenario of[3],which models a cycle-stealing opportunity such as a coffee break,wherein the risk of interruption increases very fast.The non-initial period-lengths.Applying system(4)to ,wefind that the non-initial period-lengths of an optimal schedule satisfy the recurrenceso that(10) The initial period-length.Since each is concave,we invoke the pair of inequalities(6)to obtain bounds on.Without writing out the long expressions that these inequal-ities yield,we note only that they show that,to within low-order additive terms(which involve,,and),Our approximate specification of the period-lengths of are more detailed than onefinds in[3].5.ConclusionOur experience with specific life functions,as illustratedin Section4,suggests that,despite its implicit nature,sys-tem(4)easily determines each non-initial period-length ofan optimal schedule in terms of all earlier period-lengths.Significantly,this“progressive”feature of the system al-lows one to determine only after period has ended.This means that,in principle,one could use conditional, rather than absolute,probabilities to determine schedule progressively,period by period.Determining the initial period-length remains an art:System(4)does not help in this determination,and the-instance of system(3)is usually hard to apply,except in very special cases,suchas the uniform risk scenario.The bounds on the optimal value of that we derive in Theorem1substantially narrow one’s search space for the optimal,at least for“smooth”life functions,but they usually still leave one with a factor-of-2uncertainly in determining this value.Indeed,we view the primary open problem within the framework we have studied here to be the identification of broad classes of life functions for which one can determine the optimal initial period-length definitively.Although we succeeded in this determination for the three scenarios studied in[3],we did so only by using ad hoc techniques that were specific to each particular life function.Even aside from determining definitively,much workremains to be done within the framework of our study.Mostobviously,our results expose only necessary dependencies among optimal period-lengths;they do not demonstrate that using such period-lengths guarantees the(near)optimality of the resulting schedule.(We do show in the full paper that the dependencies do guarantee“local”optimality.)While avenues toward global optimality guarantees have eluded us,one possible approach would involve answering the fol-lowing question.(Note the relevance of Theorem1(a).) Are optimal cycle-stealing schedules unique? Notably,each of the life functions studied in[3]admits a unique optimal schedule—but the techniques for verifying uniqueness there were specific to the individual life func-tion.Yet another approach to guaranteeing optimality—at least for specific classes of life functions—would be to determine when specific scheduling recipes work.One natural such recipe is to choose period-lengths“greedily:”one would choose by maximizing the function def ,then choose by maximizing the function def,and so on.For what class of life functions is a“greedy”cycle-stealing schedule optimal?More generally,how close to optimal are“greedy”schedules? Easily,the“greedy”strategy yields the optimal schedule for the geometrically decreasing lifespan scenario.In quite an-other direction,we do not yet have an answer to even the following basic question.For what class of life functions do there exist op-timal cycle-stealing schedules?Afinal set of open questions involve more technical is-sues.Our current results demand smoothness and/or a nice “shape”in our life functions.Can these assumptions be weakened?In another direction:we have had to translate what is ideally a discrete problem into a continuous frame-work in order to derive our guidelines;this was true even in the case study of[3].Can one show that our continuous guidelines yield valuable discrete analogues?It is clear from this brief list of questions that many chal-lenges remain in this important area of research. 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