Life-Cycle Models for Survivable Systems
沙利文法中健康期望寿命的测算指标
・906・中国卫生统计2019年12月第36卷第6期沙利文法中健康期望寿命的测算指标苗鑫蕾'张翔仏孟群E长期以来,期望寿命(life expectancy,LE)是评价人群健康状况的传统指标,而由于期望寿命只能反映出人们的生命长度而不能反映出人群健康的生命质量⑴,因此为了能够反映出人群的生命质量,提出了健康期望寿命(healthy life expectancy,HLE)的概念,也称为健康调整期望寿命(healthy adjusted life expectancy,HALE)o沙利文法(Sullivan method)是目前国际上流行的计算健康期望寿命的方法之一。
1971年,沙利文在美国健康教育和福利部的一份报告中提到无失能期望寿命,他使用自己的方法计算出扣除失能的期望寿命,因此使用Sullivan Health Expectancy一词作为对健康期望寿命计算方法的介绍,简称沙利文法㈢。
迄今为止,全球至少37个国家采用该方法计算健康指标。
沙利文法所需要的资料主要为特定年龄下的健康人口和非健康状态的流行率,以及特定年龄别的死亡数据⑶。
由于健康和非健康状态的患病率较小,因此建议最好为五年(有时为十年)的年龄间隔。
沙利文法计算的总体思想是在寿命表的基础上,用健康的总人年数比上健康的总人数,最后得到健康的总年数,即健康期望寿命。
计算公式为:HALE=健康总人年数健康总人数健康部分的核算1.健康的定义1948年,WHO成立时在《宪章》中对健康定义为“不仅仅是没有疾病或虚弱现象,而是一种心理、生理和社会上的完好状态。
”这个概念从生物-心理-社会医学三维模式阐述了一种现代健康观⑷。
随后,社会医学的兴起,人们对于健康的认识从个体扩大到了群体对社会环境的适应性⑸。
因此,健康是一个多维度的概念,它融合了疾病、残疾、心理障碍、行为障碍等多方面内容。
健康的核算可以通过直接核算健康部分(如:自评健康期望寿命)或者计算出非健康部分(如:*基金项目:863计划项目(2012AA02A607)1.首都医科大学公共卫生学院(100069)2.大连大学附属中山医院信息管理中心3.国家卫生健康委员会△共同通信作者:张翔,Email:zxl994@yeah,net;孟群,Email:mengqun@ 活动限制、残疾估计、疾病负担等)后间接计算健康部分。
Life Cycles
adolescent(noun)A teenager goes through manychanges as an adolescent .1.The growth spurt that an adolescentmay experience is a normal part of growing up.2.Before Elena was an adolescent , sheknew that she wanted to be a writer someday.3.seedling(noun)A seedling is a young tree thatmeasures no more than 3 feet in height.1. A seedling grows from a seed andturns into a sapling.2.He made sure the young seedlinggot plenty of sunshine and water so it would grow to be big and strong.3.egg(noun)An egg is a reproductive structure that is produced by a female animal.1.Mammals, birds, fish, insects, reptiles,and amphibians can all produce an egg .2.The egg of many animals has a protective covering that allows a fertilized embryo to develop outside the mother's body.3.embryo(noun)The yolk of a chicken egg is anembryo .1.An embryo is an unborn animal inthe early stages of development.2.The embryo , or unborn offspring,was growing inside its mother.rva(noun)A larva is an immature, wormlikeinsect that has hatched from an egg,and more than one are larvae (LAR-vee).1. A butterfly or moth larva is acaterpillar.2. A larva eats an amazing amount offood every day.3.life cycle(noun)A life cycle includes all stages ofdevelopment that a living organism goes through.1.The stages of egg, larva, pupa, and adult are the stages in the life cycle of a butterfly.2.The life cycle of most animals begins with fertilization and ends with death.3.metamorphosis(noun)A metamorphosis is a change or transformation.1.Metamorphosis results in a complete or obvious change in physical form,structure, or substance.2.The caterpillar underwentmetamorphosis by becoming a pupa and then emerging from its cocoon as a moth.3.pupa(noun)A pupa is an insect at the last stagebefore its metamorphosis into an adult.1.The pupa of a moth spins a cocoonor goes through this stageunderground or on the ground.2.The pupa of a butterfly is encasedin a chrysalis.3.adult(noun)An adult is a full-grown or mature person or other animal.1.An adult is an animal that is fully developed and is able to produce offspring.2.In deer, an adult can be a doe (female) or a stag (male).3.DAY 1SynonymDefinition _________________________________________________________________________________________________________________________________________________________________________________________________________AntonymWord PictureSynonymDefinition _________________________________________________________________________________________________________________________________________________________________________________________________________AntonymWord PictureINSTRUCTIONS: Record a vocabulary word in each word box. Then write a synonym and an antonym, draw a picture, and define each word. Use each word in a sentence on the back of this worksheet.Name: _______________________________________________________(Page 1 of 1)WORD CARD DEFINITION CARDadolescenta person between childhood and adulthood(noun)WORD CARD DEFINITION CARDseedlinga young, developing plant that has grown from aseed (noun)egga female reproductive cell; the beginning stage in the life cycle of manyorganisms (noun)WORD CARD DEFINITION CARDembryothe early stage during which a plant or animalbegins to grow(noun)WORD CARD DEFINITION CARDlarvathe caterpillar or wormlike stage in the life cycle of some insects(noun)life cyclethe stages of change that an organism goes throughduring its life (noun)WORD CARD DEFINITION CARDmetamorphosisthe transformation from an immature form to anadult form (noun)WORD CARD DEFINITION CARDpupaan immature insect in the stage between a larva andan adult (noun)adultthe stage in which a person or other animal isfully developed(noun)Name:An analogy shows a relationship between two sets of words. The words in the first pair must have the samerelationship as the words in the second pair. To complete an analogy with a missing word, you must first discover the relationship between the completed pair. (Example: Cat is to meow as dog is to bark .)baby personmalemagneticmothconsumptionwormeggchildINSTRUCTIONS: Determine the relationship between the first pair of words. Then use the words in the word box to complete thesecond pair of words.Adultis toyoung ...as...parentis to1.Seedlingis toplant...as...child is to2.Life cycle is todevelopment...as...food chainis to3.Adolescentis to teenager...as...infantis to4.Embryois to embryonic...as... magnetis to5.Metamorphosisis totransformation...as... larvais to6.Eggis to female...as...spermis to7.Pupa is to cocoon ...as... embryo is to8.Name:An analogy shows a relationship between two sets of words. The words in the first pair must have the samerelationship as the words in the second pair. To complete an analogy with a missing word, you must first discover the relationship between the completed pair. (Example: Cat is to meow as dog is to bark .)baby personmalemagneticmoth consumptionworm eggchildINSTRUCTIONS:Determine the relationship between the first pair of words. Then use the words in the word box to complete thesecond pair of words.Larva is to caterpillar ...as... adult is to9.CLOZE SENTENCESDAY 2(Page 1 of 1) Name:adolescent seedlingeggembryolarvalife cyclemetamorphosispupaadultINSTRUCTIONS:Use the vocabulary words in the word box above to complete the sentences below.The stages of development of a living organism are part of its1.An animal that is fully developed is called an2.Before it is hatched, a baby bird is called an3.Anis a person who is between childhood andadulthood.4.Ais a young plant.5.Anis a reproductive structure produced by some animals.6.Theof a butterfly develops into a pupa before becoming an adult.7.is a complete change in physicalform, structure, or substance.8.A is an insect at the stage between a larva and an adult. 9.Name:A noun is a person, place, thing, or idea. If the noun is the name of a person ora specific place, it is called a proper noun. A proper noun is always capitalized.INSTRUCTIONS: Read the words below. Decide whether the word is best classified as a person, place, thing, or idea. Then write each word in the appropriate column.adolescent seedlingeggembryolarvalife cyclemetamorphosispupaadultPERSONPLACETHINGIDEAUse each noun from the table in a sentence.1.2.3.4.5.Name:A noun is a person, place, thing, or idea. If the noun is the name of a person ora specific place, it is called a proper noun. A proper noun is always capitalized.6.7.8.9.Write three words that are not nouns.CONCEPT COMPLETIONDAY 4(Page 1 of 1) Name:INSTRUCTIONS: Use what you know about the vocabulary words to complete the following sentences.The metamorphosis of a caterpillar results in a1.A pupa will develop into2.A larva is an immature3.An adolescent experiences changes in4.An embryo develops into5.The life cycle of a human begins6.An adult is an animal that7.Two animals that can lay an egg are8.To survive, a seedling needs9.ASSESSMENTDAY 5(Page 1 of 1)Name:INSTRUCTIONS: Choose the best answer to complete each statement.Rapid physical changes are a normal part of for an adolescent. eating growing up getting sleepy1.Ais called a seedling.small flower young plant small seed2.reproduce through the laying of an egg. Mice Horses Birds3.An embryo is animal.a young a dying an unborn4.A larva is an immature egg insect mammal5.is a stage in the life cycle of a human. Adolescence Hibernation Camouflage 6.A metamorphosis is a complete development improvement transformation7.A butterfly pupa is encased in a caterpillar cocoon chrysalis8.An adult is not fully developed mature immature9.。
希金斯可持续增长模型英文文献
希金斯可持续增长模型英文文献Higgins's Sustainable Growth Model.Higgins's Sustainable Growth Model is a theoretical framework that aims to explain the relationship between economic growth and environmental sustainability. The model posits that economic growth is not inherently sustainable, and that it can only be sustained if it is accompanied by environmental protection and conservation measures.The model is based on the following assumptions:Economic growth is driven by the consumption of resources.Resources are finite.Environmental degradation is a negative externality of economic growth.The model suggests that if economic growth is not accompanied by environmental protection and conservation measures, it will eventually lead to environmental degradation. This degradation will, in turn, negatively impact economic growth, as it will reduce the availability of resources and increase the costs of production.The Higgins's Sustainable Growth Model has been used to inform a variety of policy decisions, including the development of environmental regulations and the promotion of sustainable economic practices.Chinese Answer.希金斯可持续增长模型。
肿瘤患者的灵性照护理论模型及护理
肿瘤患者的灵性照护理论模型及护理在肿瘤患者的灵性照护中,有多种理论模型可供参考使用,以下是其中一些常用的模型:1. Puchalski模型:这个模型是由美国George Washington大学医学中心的Christina Puchalski 医生提出的。
该模型提出了四个基本维度:生物、心理、社会和灵性,认为这些维度是互相关联的,不可分割的,对于患者的全面治疗起到重要作用。
2. Ferrans和Powers模型:该模型是由Ferrans和Powers在1992年提出的,主要关注患者的健康生活质量,其中包含四个维度:生理和心理状态、社会与经济状态、家庭/工作生活和精神/灵性状态。
3. C-SHIP模型:该模型是由美国哈佛医学院教授David Rosenthal提出的,并在中国开展了跨文化研究。
该模型认为照护包括身体、心理、家庭、社区和灵性方面,其中灵性包括关于人类与自然界和超自然世界的信仰和体验等方面。
4. HOPE模型:该模型由Puchalski于2004年提出,主要关注患者的灵性需求和照护。
模型中的HOPE代表着四个方面的内容:希望、组织和信仰、精神支持和生活、文化和意义。
以上是一些常用的理论模型,可以在肿瘤患者的灵性照护中进行参考使用,以提供全面的治疗和支持。
肿瘤患者的灵性照护,最新的照护方法和措施包括以下几个方面:1. 建立灵性支持团队:建立由医生、心理医生、社工、宗教领袖和志愿者组成的灵性支持团队,提供多样化的灵性照护服务,包括心灵安慰、心理辅导、信仰支持、宗教仪式和精神指导等。
2. 采用综合治疗策略:针对肿瘤患者的身体、心理、社会和灵性方面的需求,采用综合治疗策略,包括放化疗、手术治疗、康复治疗、心理疏导、社会支持和灵性照护等多种治疗方法,以提高治疗效果和缓解患者的痛苦和焦虑。
3. 强化患者自我管理:通过教育和培训,帮助患者了解和掌握自我管理技能,包括身体状况的监测和管理、情绪的调节和控制、社交和交往技巧的提高、宗教信仰的强化等方面,以提高患者的自我效能感和生活质量。
抗衰老免疫健康指南团体标准
抗衰老免疫健康指南团体标准As people age, maintaining a strong immune system becomes even more crucial. 随着年龄的增长,保持健康的免疫系统变得更加重要。
Aging is a natural process that can be accompanied by a decline in immune function. However, there are steps individuals can take to support their immune health as they age. 老化是一个自然的过程,可能会伴随着免疫功能的下降。
然而,个人可以采取措施来支持他们的免疫健康。
One important factor in maintaining a healthy immune system as we age is to prioritize a nutritious diet. 随着年龄的增长,保持免疫系统健康的一个重要因素是优先考虑均衡营养的饮食。
A diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats can provide the essential vitamins and minerals our immune system needs to function optimally. 富含水果、蔬菜、全谷物、瘦肉和健康脂肪的饮食可以提供我们免疫系统所需的维生素和矿物质,使其能够达到最佳状态。
In addition to a healthy diet, regular exercise is also important for maintaining immune health as we age. 除了健康的饮食外,定期锻炼对于我们保持免疫健康也非常重要。
干细胞释放因子抗衰老技术(SCF技术)
深圳海悦生物的专家联合国外著名科学家经过近十年的技术攻关,现在终于有了突破。多国专家联合研发的干细胞释放因子,含有干细胞生长和分化所需的各种营养和信息物质,可以快速激活组织内的干细胞,高效修复包括表皮,真皮,神经,血管,脂肪,胶原蛋白等多种组织。干细胞释放因子是目前世界领先的功能最全、效率最高、能力最强的具有各种细胞修复功能的生物产品。
海悦生物科技干细胞释放因子抗衰老技术(SCF技术)
一、干细胞释放因子技术
皮肤老化主要原因:由于皮肤组织中细胞的生长能力及活力减弱,导致皮肤所需的胶原蛋白,弹性纤维等减少,色素排泄能力下降,受损细胞不能得到及时更换,从而影响皮肤的组织结构及细胞比例。随着年龄的增加,就会出现皱纹、色斑、皮肤松弛、修复能力降低等问题。
尽管我们可以运用各种化妆品来保护和营养皮肤,但是当皮肤细胞自身失去活力的情况下,外在的给养并不能逆转皮肤本身的老化。因此,要真正解决皮肤的衰老问题,就不可避免要解决皮肤细胞的活力问题。只要能够增加或提高皮肤细胞的活力,就可以从根本上延缓衰老。
众所周知,人体各个组织器官当中都有干细胞的存在,它们的数量和质量决定了组织中细胞的功能状态。干细胞也是生命体,随着年龄的增长,体内干细胞的数量和质量也在逐渐下降,我们的皮肤和器官也就开始了衰老。那么有什么东西能够增加干细胞的数量和活力吗?
四、干细胞释放因子技术(SCF技术)的适应症:
1,各种皱纹:抬头纹、额纹、川字纹、鱼尾纹、、法令纹、嘴角皱纹、 颈纹。
2,全面部皮肤松弛、粗糙、暗淡。
3,外伤、妊娠纹、痤疮等引起的疤痕。
4,改善炎症后色素沉着、面部色斑、黄褐斑。
5,毛孔粗大、毛细血管扩张。
五、干细胞释放因子技术(SCF技术)疗程程序
项目生命周期视角下医学类科研项目风险分析与对策
中国卫生产业CHINA HEALTHINDUSTRY[基金项目]新疆医科大学第二附属医院卫生管理类课题(YWG2018-02)。
[作者简介]史建平(1977-),女,硕士,主管医师,研究方向为卫生科教管理。
[通信作者]姜小明(1963-),男,硕士,主任医师,研究方向为医院管理,E-mail:180****************。
科学研究是一种人类探索性活动,受政策、所处环境、人员、科研条件等内外部因素不确定性的影响,加之项目各方利益相关者预见性和控制度难以把握等因素,致使科研项目的最终结果与期望结果不一致,从而带来损失或机遇的可能性,称之为科研项目风险[1-2]。
和医学类有关的科学研究对于人类的发展是很重要的,与人类的健康密切联系在一起,但是医学研究会有各种因素的限制,比如国家政策与国际标准与规范等,同时进行医学研究的选题与医学伦理也会对其产生一定的影响,而在医学研究的过程当中人力资源、研究的条件与经费等都会对其产生一定的制约,一般具有研发周期较长、投入资金高、实验环节繁杂、失败率较高、易受内外部因素的影响,这些特点和其他的研究比较来看,医学研究存在的风险相对来说比较大[3-5]。
目前,医学科研项目呈现出规模和资金投入不断增加、多领域、跨地区甚至跨国、多学科交叉协作及研究等态势[6],因此其风险管理备受医疗机构、科研院所及科研管理人员普遍的关注。
生命周期主要是指一个生物从出生到死亡之间经历的所有过程,后泛指研究对象从产生到消亡的所有过程,而生命周期也通常会被运用在技术、产品等方面,一般把生命周期分为4个阶段,分别是萌芽期、成长期、成熟期以及衰退期[7-8]。
在1960年左右,美国第一次提出了生命周期理论,在1970年以后生命周期理论慢慢得到人们的重视,现如今在经济领域、信息领域等方面都有广泛的运用[9]。
DOI:10.16659/ki.1672-5654.2020.36.029项目生命周期视角下医学类科研项目风险分析与对策史建平1,潘侯梅2,姜小明31.新疆医科大学第二附属医院教学科研办公室,新疆乌鲁木齐830063;2.新疆医科大学第二附属医院病案管理科,新疆乌鲁木齐830063;3.新疆医科大学第七附属医院党院办,新疆乌鲁木齐830028[摘要]医学类科学研究关乎人类生命健康,因此其风险管理值得科研管理者关注。
CRRT的几个基本概念
Return Pressure Positive +50 to +150 mmHg
Effluent Pressure Negative or Positive >+50 to -150 mmHg
高通量旳滤器 面积 1.6-2.2平方米
HVHF
总之,对重症脓毒血症或合并休克患者, CRRT极难设定上限计量,尚需研究,超滤
率至少应≥35ml/kg/h。
Access Pressure Negative -50 to -150 mmHg
Filter Pressure Positive +100 to +250 mmHg
凝措施) 局部肝素抗凝法 局部枸橼酸盐抗凝法 低分子肝素抗凝法 无肝素抗凝法 前列腺素抗凝法
前列腺素抗凝法
原理:阻断血小板粘附功能和汇集功能 有人以为比肝素安全,半衰期极短(2min) 缺陷:停用后抗血小板活性时间长(24H) 无中和制剂 调整需依赖血小板汇集试验 药物剂量依赖性低血压发生率高 应用
技术构成三
滤器 聚砜膜(AV400及AV600)滤器 聚丙烯腈膜(AN69)滤器
AN 69
AV600
血液滤过器旳构造
血液入口
透析液和滤 出液出口
横断面
空心纤维 膜
透析液入 口
血液出口
空心纤维外面 (滤出液) 空心纤维里面 (血液)
血滤器
种类
聚砜膜
聚丙烯晴膜
聚酰胺
膜通透性
低通量滤器 <10000D
治疗中旳经典压力
治疗中旳经典压力
动脉压Access Pressure
测量当血液离开病人血液通路(例如双腔导管)时 旳压力(体外旳)
乳腺癌长期幸存者生活质量的影响因素分析
doi :10.3969/j.issn.1002-7386.2024.01.032·调查研究·乳腺癌长期幸存者生活质量的影响因素分析李坤艳 李璐璐 董涧桥 高雅楠 南璐 贾红燕项目来源:山西省回国留学人员科研资助项目(编号:2021⁃157)作者单位:030001 太原市,山西医科大学公共卫生学院(李坤艳);山西医科大学第一医院(李璐璐、董涧桥、高雅楠、南璐、贾红燕)通信作者:贾红燕 E⁃mail:swallow_jhy@ 【摘要】 目的 通过分析乳腺癌长期幸存者生活质量状况,探讨影响乳腺癌长期幸存者生活质量的相关因素。
以期为乳腺癌长期幸存者生活质量的提高,提供参考依据。
方法 结合美国癌症协会对癌症长期幸存者的定义,乳腺癌长期幸存者为自诊断以来,生存期≥5年的乳腺癌个体。
以山西医科大学第一医院2017年1~12月诊断为乳腺癌的202例乳腺癌患者为研究对象。
采用欧洲癌症研究与治疗组织生活质量核心调查表(EORTC QLQ⁃C30)对202例乳腺癌长期幸存者进行调查,调查时间2023年1~4月。
通过SPSS 26.0软件对数据结果进行分析。
结果 202例乳腺癌长期幸存者的整体生活质量得分为65.88分;EORTC QLQ⁃C30功能量表中,认知功能得分最低;症状量表中,经济困难得分最高。
多重线性回归分析显示乳腺癌长期幸存者的生活质量与体重指数、居住地、居住方式、工作状态、家庭月收入、付费方式、费用影响、临床分期以及手术方式呈显著相关。
结论 乳腺癌患者5年存活率较高,生活质量高低对评价乳腺癌患者预后尤为重要。
可通过控制患者体重指数,改善居住环境,重视早期诊治,选择合适的治疗方案,调整工作状态,提高其工作的可持续性,以改善乳腺癌患者的长期生活质量。
【关键词】 乳腺癌;长期幸存者;生活质量;影响因素【中图分类号】 R 737.9 【文献标识码】 A 【文章编号】 1002-7386(2024)01-0137-06Analysis of factors influencing quality of life in long⁃term breast cancer survivors LI Kunyan ∗,LI LuLu ,DONG Jianqiao ,et al.∗School of Public Health ,Shanxi Medical University ,Shanxi ,Taiyuan 030001,China【Abstract 】 Objective To provide reference for improving the quality of life in long⁃term breast cancer survivors by analyzing its influencing factors.Methods Based on the American Cancer Society guideline ,a long⁃term breast cancer survivor was defined as an individual with breast cancer who had survived for at least 5years since being diagnosed.A total of 202patients diagnosed with breast cancer in the First Hospital of Shanxi Medical University from January 2017to December 2017were recruited.The 202long⁃term breast cancer survivors were surveyed between January 2023and April 2023using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ⁃C30).Data were analyzed by SPSS 26.0software.Results The mean score of the overall quality of life of 202long⁃term breast cancer survivors was 65.88points.In the EORTC QLQ⁃C30functional scale ,the cognitive function score was the lowest.Financial hardship scored was the highest in the EORTC QLQ⁃C30symptom scale.Multiple linear regression analysis showed that the quality of life of long⁃term breast cancer survivors was significantly correlated with body mass index ,residence ,living style ,working status ,monthly family income ,payment method ,cost impact ,clinical stage and surgical method.Conclusion The 5⁃year survival rate of breast cancer patients is high ,and the quality of life is particularly important to evaluate their prognosis.The long⁃term quality of life of breast cancer patients can be improved by controlling the body mass index ,improving the living environment of patients ,emphasizing the early diagnosis and treatment ,selecting the appropriate treatment plan ,adjusting the working status ,and improving the sustainability of their work.【Key words 】 breast cancer ;long⁃term survivors ;quality of life ;impact factors 乳腺癌是女性最常见的恶性肿瘤之一,我国女性乳腺癌发病率近几年呈上升趋势[1-2]。
Vaisala PWD 系列气象传感器说明书
Key benefitsThe right instrument for the right purposeThe range of visibility instrumentation in the PWD Series ensures the right combination of technology and sensors. This allows you to capture the precise data that satisfies your navigation and planning objectives without overspending on capabilities you don’t need.Easy installation and expandabilityPWD sensors are compact andlightweight (less than 1m long), and are factory-calibrated and plug-and-play ready. They can function stand-alone or as part of an Automated Weather Observing System (AWOS) with flexible mounting on existing masts. Measurement capabilities for all PWD models have easy and economical upgrades to meet your changing measurement needs over time.Accuracy in all conditionsVaisala’s pioneering sensor design enables the PWD Series to provideconstant, reference-grade performance unmatched by other forward scatter technology — even for intenseprecipitation and mixed precipitation.Economical operation and maintenanceThe rugged design uses no movable or consumable parts and is well protected against contaminationwith the optical components pointed downward. Hoods protect the lenses against precipitation, spray, and dust. Its weatherproof design provides accuracy, reduces maintenance, and delivers low life cycle costs.Vaisala Present Weather and Visibility Sensors PWD Series is designed to meet the unique challenges of visibility and present weather measurement for onshore and offshore maritime operations, including harbors,coastal areas, ships, and offshore platforms. Vaisala’s PWD Series is the industry standard, approved by major oil companies.The PWD Series delivers a mix of visibility reporting range (Meteorological Optical Range or MOR), characterization of reduced visibility, precipitation type identification, precipitation accumulation/intensity measurement, and report formats (WMO, NWS code tables). It also includes analog and serial line output and optional hood heaters for winter conditions. The PWD Series provides off-the-shelf accuracy and reliability and can be easily and economically upgraded. Wherever visibility reporting is necessary,Vaisala offers a cost-effective and reliable solution that grows to meet your measurement needs.The visibility at sea depends on many factors, such as humidity, wind speed, temperature, and precipitation. It may sound simple, but any meteorologist will tell youthat visibility is one of the hardest parameters to accurately measure and forecast.Vaisala Present Weather and Visibility Sensors PWD SeriesThe right visibility data for maritime use, at the right priceProduct SpotlightPWD Series at a glanceApplications• Feeding visibility and present weather into shipboard weather systems to optimize route and operational planning.• Informing harbor travel protocols to ensure safe operations in poor visibility.• Monitoring conditions around offshore platforms for effective coordination of supply vessels, helicopters, and other operational support traffic.• Generating detailed forecasts to inform early warning and safety protocols.• Integrating visibility and present weather capture capabilities into an onshore, ship, or offshore platform AWOS. • Calculating visibility information that ships can use to determine safe passage routes into and out of harbors.Key featuresExceptional data capture that measures visibility in maximum ranges from 2 to 50km (1 to 27NM) MOR. Advanced models also capture present weather information.Rugged, weather-proof design that ensures low maintenance need and high data availability.Down-looking sensor hoods protect the optical surfaces from external contaminants.Forward scatter visibility sensors for greater accuracy in calculating visibility.Capacitive RAINCAP® precipitation sensors in advanced models detect multiple precipitation types,intensity, and accumulation.Optional hood heaters prevent the buildup of ice and/or snow in the optical path.Why Vaisala? Experiencewith perspectiveHaving launched our first forward-scatter sensor in1990, Vaisala is a trustedpartner in visibility and precipitation sensors. Our unique understanding of weather measurement has made Vaisala a leader in maritime and aviation weather observation solutions. The technologies we offer are the result of our own R&D,and our solutions and services are used in environmental monitoring systems,helideck monitoring systems, and marine weather reporting worldwide. Our extensive expertise and global presence — with more than 20,000 devices in over 120 countriesand all seven oceans — makesus your global maritimeweather expert.Support to count on Look to Vaisala for dependable support, project capabilities, and training so you can get the most from your system. We provide project management, installation, training, acceptance testing, engineering, consulting,and ongoing service agreements. With decades of experience providing the best technologies and the finest support, Vaisala’s philosophy of partnership is unmatched in the industry. Scan the code formore information Ref. B212256EN-B ©Vaisala 2020This material is subject to copyright protection, with all copyrights retained by Vaisala and its individual partners. All rights reserved. Any logos and/or product names are trademarks of Vaisala or its individual partners. The reproduction, transfer, distribution or storage of information contained in this brochure in any form without the prior written consent of Vaisala is strictly prohibited. All specifications — technical included — are subject to change without notice.。
人工智能对实现全生命周期健康管理的作用英语作文
人工智能对实现全生命周期健康管理的作用英语作文Title: The Role of Artificial Intelligence in Achieving Full Lifecycle Health ManagementIn the dawn of the digital age, healthcare is undergoing a profound transformation, with artificial intelligence (AI) at the forefront of this revolution. AI's integration into healthcare systems is not merely a technological advancement; it's a game-changer that promises to revolutionize the way we approach health management across our entire lifespan.Firstly, AI empowers preventive medicine, the cornerstone of full lifecycle health management. By analyzing vast amounts of health data, including genetic information, lifestyle habits, and environmental factors, AI algorithms can identify individuals at risk of developing certain diseases before symptoms manifest. This predictive capability allows for early interventions, such as personalized diets, exercise routines, or even medications, thereby delaying or preventing the onset of chronic conditions like heart disease, diabetes, and cancer.Furthermore, AI streamlines diagnostic processes, ensuring prompt andaccurate treatment. Radiology and pathology, once reliant heavily on human expertise, now benefit from AI's ability to analyze images and tissue samples with unparalleled precision. This not only improves diagnostic accuracy but also reduces wait times for patients, enabling quicker access to care. In emergency situations, AI-assisted triage systems can prioritize patients based on severity of illness, optimizing resource allocation and saving lives.The role of AI extends beyond diagnosis to personalized treatment plans. By integrating patient data with the latest medical research, AI can recommend tailored therapies that are most likely to be effective, considering an individual's unique biology and health history. This precision medicine approach enhances treatment outcomes and minimizes adverse reactions.Moreover, AI fosters continuous monitoring and remote healthcare, transforming post-treatment care. Wearable devices and smart home systems integrated with AI can monitor patients' vital signs and report anomalies in real-time, enabling early detection of complications and swift intervention. For the elderly or those with chronic conditions, this remote monitoring can significantly enhance quality of life and reduce hospitalizations.Lastly, AI's impact on health education and research is profound. By analyzing clinical trials and research data, AI accelerates the discovery of new treatments and drugs. Additionally, it democratizes access to health information, making complex medical concepts accessible to the general public through interactive platforms and chatbots.In conclusion, artificial intelligence is a pivotal force in achieving full lifecycle health management. Its capabilities span from preventive medicine and precision diagnosis to personalized treatments and continuous monitoring, revolutionizing the healthcare landscape. As AI continues to evolve, its potential to improve human health and well-being becomes increasingly limitless.Translation:标题:人工智能在实现全生命周期健康管理中的作用在数字时代的黎明,医疗保健正在经历深刻的变革,而人工智能(AI)则在这一变革中处于前沿地位。
11 Life cycle model 资产组合PPT 金融系,研究生课程课件
20
50万初始股票投资的居民在考虑背 景风险前后面临损失的比较(万元)
1%坏的情 形
5%坏的情 形
只考虑股票 投资 19.58
11.06
考虑房产背景
考虑收入 背景
25.28
19.54
11.87
8.99
考虑收入与房地 产背景 24.18
10
Parameters and result
11
Parameters and result
12
BSM Model III:wage is volatile
ቤተ መጻሕፍቲ ባይዱ
• Add another variable, suppose wage’s volatility is k times of stock’s.
– d ω =g ω dt+kσ ω dz
• 令D*(t)为风险资产的投资需求(以元为单位),则 个人在风险资产上的等于他的总投资减去他的人 力资本风险头寸 :
– D*(t)≡x*W(t)-kH(w(t), t)=x*F+(x*-k)H(w(t), t)
• 或者:
– X^*(t)≡D*(t)/F(t)=x*+(x*-k)H/F
L(t) + h(t) = 1.
6
BMS Model I: When labor is flexible
• Target:J(W,w,t)= max Et[∫0Te-δs u(C(s), L(s))ds] ---(Continuous)
– Example: u(C, L)=log(C)+Гlog(L)
用(1)除以(2),得到:
(3)
MELD评分、ALBI评分联合β2-微球蛋白对肝硬化合并急性肾损伤的预测价值
·肝纤维化及肝硬化·DOI:10.3969/j.issn.1001-5256.2023.12.014 MELD评分、ALBI评分联合β2-微球蛋白对肝硬化合并急性肾损伤的预测价值王朋,李泽宇,蒋亚婷,尚成,王红郑州大学第一附属医院消化内科,郑州 450000通信作者:王红,********************(ORCID: 0009-0002-1977-3612)摘要:目的 探讨终末期肝病模型(MELD)评分、白蛋白-胆红素(ALBI)评分和β2-微球蛋白联合检测对肝硬化合并急性肾损伤(AKI)的诊断价值。
方法 收集2019年10月—2022年10月在郑州大学第一附属医院就诊的258例肝硬化患者的临床资料,根据是否合并AKI分为AKI组(n=117)和非AKI组(n=141),比较AKI组和非AKI组以及不同肾损伤分期患者之间各指标变化。
符合正态分布的计量资料两组间比较采用成组t检验,多组间比较采用单因素方差分析;不符合正态分布的计量资料两组间比较采用Mann-Whithey U检验,多组间比较采用Kruskal-Wallis H检验。
计数资料两组间比较采用χ2检验。
绘制受试者工作特征曲线(ROC曲线)评估各指标对肝硬化合并AKI的诊断效能。
结果 肝硬化合并AKI组在年龄(t=2.307,P=0.022)、合并肝性脑病(χ2=18.064,P<0.001)、合并自发性腹膜炎(χ2=16.397,P<0.001)、病死率(χ2=45.251,P<0.001)、肌酐(Z=−8.737,P<0.001)、β2-微球蛋白(Z=−8.829,P<0.001)、CTP评分(Z=−4.058,P< 0.001)、ALBI评分(t=2.563,P=0.011)、MELD评分(Z=−5.628,P<0.001)上明显高于非AKI组,住院天数(Z=−3.391,P= 0.001)少于非AKI组。
新生儿精氨酰琥珀酸尿症一例并文献复习
新生儿精氨酰琥珀酸尿症一例并文献复习胡启发1,高镝2,苏喆1,31.遵义医科大学珠海校区,广东珠海519041;2.深圳市儿童医院新生儿科,广东深圳518026;3.深圳市儿童医院内分泌科,广东深圳518038【摘要】精氨酰琥珀酸尿症是一种罕见的常染色体隐性遗传病,属于尿素循环障碍性疾病的一种类型。
临床表现从无症状到出现高氨血症的相关症状,包括肝功能障碍、神经认知缺陷、行为异常和学习障碍等。
本文报道了1例ASL 基因突变导致新生儿期发病的精氨酰琥珀酸尿症,回顾分析ASL 基因突变导致精氨酰琥珀酸尿症的临床特点及诊治过程,并结合相关文献进一步分析,以提高临床医生对这一罕见疾病的早期识别。
【关键词】新生儿;精氨酰琥珀酸裂解酶;精氨酰琥珀酸尿症;尿素循环障碍【中图分类号】R722【文献标识码】D【文章编号】1003—6350(2023)17—2567—04A case of neonatal arginosuccinic aciduria and literature review.HU Qi-fa 1,GAO Di 2,SU Zhe 1,3.1.Zunyi Medical University (Zhuhai Campus),Zhuhai 519041,Guangdong,CHINA;2.Department of Neonatology,Shenzhen Children's Hospital,Shenzhen 518026,Guangdong,CHINA;3.Department of Endocrinology,Shenzhen Children's Hospital,Shenzhen 518038,Guangdong,CHINA【Abstract 】Argininosuccinic aciduria is a rare autosomal recessive disorder,a type of urea cycle disorder.Clin-ical manifestations range from asymptomatic to the symptoms associated with hyperammonemia,including liver dys-function,neurocognitive deficits,behavioral abnormalities,and learning disabilities.This paper reported a case of ar-ginosuccinuria in the neonatal period,reviewed the clinical characteristics and diagnosis and treatment of arginuria,and further analysis combined with relevant literature to improve the early identification of this rare disease by clini-cians.【Key words 】Newborn;Arginylsuccinate lyase;Arginylsuccinuria;Urea cycle disorder ·个案报道·doi:10.3969/j.issn.1003-6350.2023.17.028基金项目:广东省卫生健康委员会高水平临床重点专科(深圳市配套建设经费)项目(编号:SJGSP012);广东省深圳市科技计划支柱可持续发展专项(编号:KBXFJ20201221173400002)。
2019142-首个逆转衰老的临床正在招募受试者!花100万美元,逆转衰老20年,这笔“交易”你干不干?
首个逆转衰老的临床正在招募受试者!花100万美元,逆转衰老20年,这笔“交易”你干不干?这个世界太疯狂了,我们才写了靶向衰老的基因疗法,提到2012年用于小鼠的A A V-T E R T基因疗法延长了成年和老年小鼠寿命,并且没有癌症风险(请参考 80岁?100岁?120岁?基因疗法可能让我们活得更久或更健康)。
这边我们就发现N I H 的临床试验官网(c l i n i c a l t r i a l s.g o v)上已经有公司发起了一项在人体的临床试验(N C T04133649)[1]。
这项临床试验是世界首个获得I R B(机构伦理审查委员会)批准的旨在逆转人类衰老20年的临床试验。
现在正在招募受试者。
等一下!让我先按捺一下激动的心情,再来给大家讲讲这项临床试验的来龙去脉。
0101振奋人心的新闻2019年11月21日Libella Gene Therapeutics (后文简称Libella )公司发布了一条震撼、震惊、振奋人心的新闻:“突破性基因疗法临床试验是世界上第一个旨在逆转人类20年衰老的临床试验”[2]。
这篇新闻之所以令人如此激动,是因为L i b e l l a 公司发起的这项临床试验,不再只是针对糖尿病肾病(S e n o l y t i c s 疗法)或者各种人类疾病(二甲双胍),而是直指衰老!这项n e w s试验的获批(注意,是获得I R B批准,并非F D A批准)意味着我们终于可以站在“衰老”这个终极大b o s s面前了!至于能不能打败它就要等待2021年的1月来看临床试验结果咯。
但是,这并不是一个免费参与的项目 ,即使合格的受试者也要交纳100万美元的费用后,才可以前往哥伦比亚(南美洲)在严格控制的医院环境下接受基因治疗(当然,参与试验前,您还要签署一份知情同意书,这是常规操作)。
0202这项临床试验的细节这个临床试验项目于2019年10月21日首次在N I H临床试验网站上发布,最近一次更新是在10月28日,也就是已经发布了一个多月了。
新的人细胞周期控制相关蛋白及其编码序列[发明专利]
专利名称:新的人细胞周期控制相关蛋白及其编码序列专利类型:发明专利
发明人:顾健人,杨胜利
申请号:CN01804917.6
申请日:20010212
公开号:CN1400977A
公开日:
20030305
专利内容由知识产权出版社提供
摘要:本发明公开了一类新的具有抑癌功能的人蛋白,编码此多肽的多核苷酸和经重组技术产生该多肽的方法。
本发明还公开了此多肽用于治疗多种疾病如癌症等的方法。
本发明还公开了抗此多肽的拮抗剂及其治疗作用。
本发明还公开了编码这类新的具有抑癌功能的人蛋白的多核苷酸的用途。
申请人:上海市肿瘤研究所
地址:上海市斜土路2200弄25号
国籍:CN
代理机构:上海专利商标事务所
代理人:徐迅
更多信息请下载全文后查看。
基于周期分析法对宫颈癌患者5年生存率评估与预测分析
•论著・基于周期分析法对宫颈癌患者5年生存率评估与预测分析王黎1,胡榕2,许倩11.湖南省常德市第一人民医院妇科,湖南常德415000;2.湖南省常德市第一人民医院儿科摘要:目的了解常德市第一人民医院宫颈癌患者近5年相对生存率,并预测未来5年相对生存率,为常德市宫颈癌防治提供数据信息和科学依据。
方法根据该院肿瘤登记数据库,采用周期分析法评估2010—2014年宫颈癌患者的5年相对生存率,并按照诊断年龄、乡镇地区进一步分层分析。
通过在周期分析法的基础上建立广义线性模型,预测未来2015—2019年期间患者的5年相对生存率。
结果2005—2019年,45-54岁年龄组宫颈癌发病率最高,占比40.54%。
74岁以上年龄组宫颈癌发病率最低,占比2.72%。
2010—2014年常德市第一人民医院宫颈癌患者总体5年相对生存率是92.73%,<45岁、45-54岁、55-64岁、65-74岁和>74岁的患者5年相对生存率分别是93.51%、92.82%、89.16%、85.71%和63.83%,城镇与乡村患者的5年相对生存率分别是94.73%和91.86%。
预测2015—2019年总体5年相对生存率是93.78%。
结论与前两个5年时期相比,未来2015—2019年期间患者的5年相对生存率仍然呈现上升趋势,年龄差异梯度继续保持,城乡差异进一步减小。
关键词:肿瘤登记;宫颈癌;5年相对生存率;基于模型的周期法中图分类号:R181文献标识码:A文章编号:1006-2483(2021)02-0073-04DOI:10.3969/j.issn.1006-2483.2021.02.017Evaluation and prediction analysis of5-year survival rate of cervicalcancer patients based on cycle analysisWANG Li1,HU Rong2,XYU Qian11.Department of Gynecology,First People's Hospital,Changde City,Hunan415000,China;2.Department of Pediatrics,First People's Hospital of Changde City,Hunan415000,ChinaCorresponding author:HU Rong,Email:7763493@Abstract:Objective To understand the relative survival rate of cervical cancer patients in our hospital in the past5 years,and to predict the relative survival rate in the next5years.The study can provide data information and scientific basis for cervical cancer prevention and treatment in Changde City.Methods According to the tumor registration database of our hospital,the5-year relative survival rate of cervical cancer patients from2010to2014was evaluated by the cycle analysis method,and further stratified analysis was carried out according to the age of diagnosis and the township area.By establishing a generalized linear model based on the cycle analysis method,we predict the5-year relative survival rate of patients in the future2015-2019period.Results From2005to2019,the incidence of cervical cancer was the highest in the45-54age group,accounting for40.54%.The incidence of cervical cancer was the lowest in the age group over74, accounting for2.72%.From2010to2014,the overall5-year relative survival rate of cervical cancer patients in our hospital was92.73%,and the5-year relative survival rates of patients<45,45-54,55-64,65-74,and>74years old were93.51%,92.82%,89.16%,85.71%and63.83%,respectively.The5-year relative survival rates of urban and ruralpatients were94.73%and91.86%,respectively.It is predicted that the overall5-year relative survival rate from2015to 2019is93.78%.Conclusion Compared with the previous second5-year periods,the5-year relative survival rate of patients in the future2015-2019will still show an upward trend,the age difference gradient will continue to be maintained, and the urban-rural difference will further decrease.Keywords:Tumor registration;Cervical cancer;5-year relative survival rate;Model-based cycle method第一作者简介:王黎,硕士,副主任医师,硕士研究生导师,主要研究方向:妇科肿瘤通信作者:胡榕,副主任医师,Email:7763493@宫颈癌是全球范围内女性常见恶性肿瘤之一⑴。
生命周期成本与生命周期评价:集成模型与协同路径
生命周期成本与生命周期评价:集成模型与协同路径生命周期成本(Life Cycle Cost, LCC)和生命周期评价(Life Cycle Assessment, LCA)是两种用于评估产品或系统综合性能和可持续性的方法。
生命周期成本主要关注产品或系统的整个使用寿命期间的成本,包括采购、维护、运营和处理等方面;生命周期评价则关注产品或系统的整个生命周期内的环境影响,包括资源消耗、能源消耗、排放物和废弃物等方面。
在实际应用中,生命周期成本和生命周期评价往往相互补充,并通过集成模型和协同路径的方法来实现综合评价。
集成模型是将生命周期成本与生命周期评价整合到一起进行分析和评价的模型,而协同路径是通过协同的方式,将两者的数据和结果进行比较和协调,以达到更综合的评价目的。
集成模型与协同路径的方法有助于在产品或系统设计阶段就能够综合考虑成本和环境影响,从而在产品或系统生产和使用阶段就能够达到经济、环保和可持续的目标。
本文将从概念、方法和应用方面对集成模型与协同路径进行详细介绍。
一、集成模型的概念集成模型的基本原理是将生命周期成本和生命周期评价的数据整合到一个统一的框架中,通过一定的方法和工具对数据进行整合和比较,以实现综合评价的目的。
集成模型的核心思想是在产品或系统设计阶段就考虑成本和环境影响,从而在产品或系统的整个生命周期内达到经济、环保和可持续的目标。
在集成模型中,主要采用以下几种方法来整合生命周期成本和生命周期评价的数据:1. 数据整合:通过收集产品或系统的相关数据,包括成本、能源消耗、排放物、废弃物等方面的数据,并进行整合和比较,以达到综合评价的目的。
2. 模型构建:通过建立一定的分析模型和评价模型,对生命周期成本和生命周期评价的数据进行分析和评价,以得出综合的评价结果。
3. 目标设定:在集成模型中,可以根据实际需要设定相应的综合评价目标,如经济性、环保性和可持续性等方面的目标,以指导综合评价的具体过程。
健康期望寿命的Sullivan方法和增减寿命表方法的评价
健康期望寿命的Sullivan方法和增减寿命表方法的评价王梅华;柳青
【期刊名称】《中国卫生统计》
【年(卷),期】2002(019)001
【摘要】目的比较健康期望寿命的Sullivan方法和增减寿命表方法计算结果的差异,考核Sullivan方法的有效性.方法构造不同的方案来变化发病率、死亡率和恢复率,根据模拟人群比较两种方法的计算结果.结果当各种率以一定的速度持续递减时,两种方法的计算结果非常接近;当各种率突然较大幅度变化时,Sullivan方法的估计值与增减寿命表方法的真值偏差较大,但是随着时间的增加,两者的差值逐渐减少,并最终达到两者相同.结论 Sullivan方法的计算结果基本上可以反映实际的健康状况,可以用Sullivan方法来监测人群健康状况的变化.
【总页数】3页(P17-19)
【作者】王梅华;柳青
【作者单位】中山医科大学肿瘤中心,510060;中山医科大学卫生统计教研室【正文语种】中文
【中图分类】R19
【相关文献】
1.老年健康期望寿命的研究方法 [J], 姜晶梅
2.寿命表方法在慢性病疗效评价上的应用 [J], 施济民;姜明
3.Elandt-Johnson模型推算完全寿命表方法学原理及其在中国人群寿命表中的应
用 [J], 安澜; 郑荣寿; 张思维; 杨谨成; 孙可欣; 曾红梅
4.基于无人机摄影测量的增减挂钩耕地指标检查与评价方法 [J], 李运健; 陈玉鑫; 初爱萍
5.老年健康期望寿命的研究方法 [J], 姜晶梅
因版权原因,仅展示原文概要,查看原文内容请购买。
- 1、下载文档前请自行甄别文档内容的完整性,平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益,请联系客服反馈,我们会尽快为您处理(人工客服工作时间:9:00-18:30)。
2 SYSTEM DEVELOPMENT LIFE-CYCLE MODELS FOR SURVIVABILITY
Most development organizations find it necessary to use different life-cycle models for different projects, depending on the nature of the project. Some of the approaches in use today include the waterfall model, spiral model, COTS integration model, incremental development model, and evolutionary model, to name just a few. In this paper, we select one model, the spiral model, and adapt it for survivable systems. We also discuss typical development activities, and illustrate how survivability might be incorporated into each activity. The generalized “pure” spiral process [Mills 86, Boehm 89] provides a framework for more specialized models. Specialization and enhancement consist of adapting the activities carried out under the model to the special
Spiral Process Model
Spiral Process Model with survivability added to every activity
Figure 1. Specialization of the Spiral Model for Survivability Driver Survivable systems must satisfy a variety of conflicting interests. End users want these systems to carry out their primary operational mission, possibly at the expense of violating security policies under some circumstances. It is often the case that systems must also satisfy some certification or accreditation authority. The steps required for these approvals may conflict with the interests of users. And developers want to finish the job, preferably ahead of schedule and under budget. Within the development organization, tensions may exist between the various specialties involved. Resolving these conflicts may involve constraining the environment and the development process. In addition, cost considerations are always present. The spiral development process has proven to be more cost effective than traditional methods, but exhibits a unique distribution of cost with time. Under the spiral model, expenditures are typically higher in early specification and design activities, resulting in cost savings in later implementation and integration activities. Table 1 identifies a typical set of broad system development activities and the corresponding survivability elements of each. The key point is that survivability is integrated into the broader activities. For example, in defining system requirements, function, performance, dependability, scalability, and other properties must be defined, as well as survivability attributes. The activities in Table 1 comprise the survivability subject matter for project management under the specialized spiral model of Figure 1. In illustration, consider the following imagined application of the spiral management process to the architecture
Life-Cycle Models for Survivable Systems
Nancy R. Mead, Robert Ellison, Richard C. Linger, Howard F. Lipson, John McHugh CERT/Software Engineering Institute Carnegie Mellon University
Primary Motivation/Driver: Primary Constraints: Mission Organization Environment Cost Schedule Knowledge Technology ...来自Foundation:
Functionality Performance Dependability Scalability ... Add Survivability
1 SURVIVABILITY AND THE SYSTEM LIFE CYCLE
Today’s large-scale, highly distributed, networked systems improve the efficiency and effectiveness of organizations by permitting whole new levels of organizational integration. However, such integration is accompanied by elevated risks of intrusion and compromise. Incorporating survivability capabilities into an organization’s systems can mitigate these risks. As an emerging discipline, survivability builds on related fields of study (e.g., security, fault tolerance, safety, reliability, reuse, performance, verification, and testing) and introduces new concepts and principles. Survivability focuses on preserving essential services, even when systems are penetrated and compromised [Anderson 97, Ellison 99]. Current software development life-cycle models are not focused on creating survivable systems, and often exhibit shortcomings in developing systems with a high degree of assurance of survivability [Marmor-Squires 88]. If addressed at all, survivability is often relegated to a separate thread of project activity, and treated as an add-on property. This isolation of survivability considerations from primary system development tasks results in an unfortunate separation of concerns. Survivability should be integrated and treated on a par with other system properties, to develop systems with required functionality and performance that can also withstand failures and compromises. Important design decisions and tradeoffs become more difficult when survivability is not integrated into the primary development life cycle. Separate threads of activities are expensive and labor-intensive, often resulting in duplication of effort in design and documentation. In addition, tools for supporting survivability engineering are often not integrated into the software development environment. With separate threads of activities, it becomes more difficult to adequately address high-risk issues of survivability and consequences of failure. In addition, technologies that support survivability goals, such as formal specification, architecture tradeoff methods, intrusion analysis, and survivability design patterns, are not effectively applied into the development process. For each life-cycle activity, survivability goals should be addressed and methods to improve survivability incorporated. In some cases, existing development methods can enhance survivability. Current research is creating new methods that can be applied; however, more research and experimentation is required before the goal of survivability can become a reality.