Re-evaluation of the LHC potential for the measurement of Mw
夸克英语作文
夸克英语作文In the realm of particle physics, quarks are the fundamental building blocks of matter, akin to the alphabet letters that make up the diverse lexicon of our universe. These elementary particles are bound together by the strong force, one of the four fundamental forces of nature, and they are never found in isolation. The study of quarks and their interactions is not just a scientific endeavor; it's a journey into the very fabric of existence.Quarks come in six different "flavors": up, down, charm, strange, top, and bottom. Each flavor has its own unique properties, such as mass and electric charge. The lighter quarks, up and down, are the most common and form the protons and neutrons in the atomic nucleus. The heavier quarks, on the other hand, are less stable and quickly decay intolighter ones.The discovery of quarks was a monumental leap in our understanding of the universe. It was in the 1960s when physicist Murray Gell-Mann proposed the quark model, which was later confirmed by deep inelastic scattering experiments. This model revolutionized the field of particle physics and earned Gell-Mann the Nobel Prize in Physics.Quarks are held together by gluons, which are the mediator particles of the strong force. This force is so powerful that it overcomes the quarks' natural tendency todisperse. The strong force is also responsible for the phenomenon of color charge, a quantum property that quarks possess. Each quark can exist in one of three color states, and the force only allows quarks to combine in such a waythat they form a color-neutral state, like the protons and neutrons in an atom.The study of quarks has led to the development of the Standard Model of particle physics, which describes the electromagnetic, weak, and strong forces. Despite its successes, the Standard Model is not without its limitations. It does not, for example, account for gravity or the nature of dark matter, which is believed to make up a significant portion of the universe's mass.As scientists continue to probe the depths of the subatomic world, quarks remain at the forefront of research. The Large Hadron Collider (LHC) and other particle accelerators are instrumental in these investigations, providing a window into the high-energy interactions of quarks and the potential for discovering new particles or forces.In conclusion, quarks are not just esoteric particles of interest to physicists; they are the cornerstone of the matter that makes up everything we see and touch. The quest to understand their nature and the forces that govern them is a testament to human curiosity and our relentless pursuit of knowledge. As we continue to unravel the mysteries of quarks, we gain a deeper appreciation for the intricate and awe-inspiring design of the universe.。
有关未来的英语作文
The future is a topic that sparks endless imagination and speculation.When writing an essay about the future in English,there are several aspects you can explore,such as technological advancements,societal changes,environmental issues,and personal aspirations.Here are some ideas to consider when crafting your essay:1.Technological Advancements:Discuss how artificial intelligence might become an integral part of daily life,from personal assistants to selfdriving cars.Explore the potential of virtual reality for education,entertainment,and remote work. Consider the impact of nanotechnology on medicine,with the ability to target diseases at a cellular level.2.Societal Changes:Reflect on how societies might evolve to become more inclusive and diverse,with a focus on equality and social justice.Examine the role of education in shaping future generations,and how it might adapt to new technologies and global challenges.Consider the potential for a universal basic income and its implications for work and leisure.3.Environmental Issues:Address the challenges of climate change and how future generations might combat it through sustainable practices and renewable energy sources.Discuss the importance of conservation efforts and how technology can aid in preserving biodiversity.Consider the role of urban planning in creating ecofriendly cities that are both habitable and environmentally conscious.4.Personal Aspirations:Write about your own dreams and goals for the future,whether they involve a career, travel,or personal development.Reflect on how you plan to contribute to society and make a positive impact on the world.Consider the skills and qualities you believe will be important for success in the future, such as adaptability,creativity,and empathy.5.Globalization and International Relations:Analyze how globalization might continue to shape the world,influencing culture, economics,and politics.Discuss the potential for increased international cooperation in areas such as spaceexploration and global health initiatives.Consider the challenges of maintaining cultural identities in a globalized world and the importance of preserving diversity.6.The Role of Space Exploration:Explore the possibilities of colonizing other planets and the technological advancements that might make space travel more accessible.Discuss the scientific discoveries that could be made through further exploration of our solar system and beyond.Consider the ethical implications of space exploration and the potential for international space governance.7.Healthcare and Medicine:Discuss the potential for advancements in medical technology,such as personalized medicine based on genetic profiles.Consider the role of technology in improving healthcare accessibility and affordability. Reflect on the challenges and opportunities presented by an aging global population and the need for innovative healthcare solutions.8.The Future of Work:Examine how the nature of work might change with the rise of automation and the gig economy.Discuss the importance of lifelong learning and adaptability in a rapidly changing job market.Consider the potential for new forms of employment and the skills that will be in demand in the future.When writing your essay,remember to use clear and concise language,provide examples to support your points,and engage your reader with thoughtprovoking questions or scenarios.The future is a canvas for endless possibilities,so let your imagination guide you as you explore the many facets of what lies ahead.。
Hendrich跌倒风险评估量表对成年住院患者跌倒风险预测效度的Meta分析
.专科研究•Hendrich跌倒风险评估量表对成年住院患者跌倒风险预测效度的Meta分析*唐文,马梦宁,刘宇,刘佳琳,吕思漫,冯晓玉,倪翠萍(中国医科大学护理学院,辽宁沈阳,110122)[摘要]目的通过对诊断性研究进行Meta分析,评价Hendrich跌倒风险评估量表(Hendrich fall risk model,HFRM)预测住院患者跌倒风险的有效性。
方法系统检索中英文数据库(包括中国知网.PubMed.Web Of Science等10个数据库),选择使用HFRM评估住院患者跌倒风险的诊断性研究。
由两名研究者共同检筛符合纳入与排除标准的文献,并进行资料提取,利用诊断性研究质量评价工具对纳入的文献进行质量评价。
使用Review Man5.3和Meta Disc1.4软件进行Meta分析。
结果最终纳入13篇文献,共238455例患者。
纳入的文献间存在阈值效应(r=0.775,P=0.002)o进行Meta回归,将文献按地区分为发展中国家组和发达国家组,发展中国家组的合并灵敏度、特异度、阳性似然比、阴性似然比、诊断比值比、AUC值、Q指数分别为0.73(95%C&0.66~0.79)、0.81(95%C/=0.80~0.83)、3.19(95%C&2.15~4.72)、0.34(95%C& 0.21-0.54).10.45(7.03~15.50)、0.83、0.77;发达国家组拟合SROC曲线,合并AUC值为0.716.Q指数为0.666o结论HFRM对于成年住院患者跌倒风险的评估具有较高的准确性。
[关键词]Hendrich跌倒风险评估量表;跌倒;成年住院患者;预测效度;Me塢分析[中图分类号]R47[文献标识码]A[文章编号]1671-8283(2021)*0044-08[DOI]10.3969/j.issn.1671-8283.2021.04.008 Predictive validity of Hendrich fall risk model for adult inpatients in risk of falling:a meta-analysis Tang Wen,Ma Mengning,Liu Yu,Liu Jialin,Lv Siman,Feng Xiaoyu,Ni Cuiping//Modem Clinical Nursing,-2021,20(4):44.(School of Nursing,China Medical University,Shenyang,110012,China)[Abstract]Objective To evaluate the effectiveness of the Hendrich Fall Risk Model(HFRM)by diagnostic accuracy study of meta-analysis,in predicting the risk of falling of inpatients.Methods Ten English and Chinese databases were systematically searched including CNKI,PubMed,Web Of Science,etc..Hendrich Fall Risk Model for assessment of the risk of falling among inpatients were selected in the study.The data were extracted from the acquired literatures by two researchers following the inclusion and exclusion criteria.Quality assessment of diagnostic accuracy studies-2(QUADAS-2)was applied to evaluate the quality of the included literatures.Review Man5.3and Meta Disc1.4software were used for meta-analysis.Results A total of13literatures were included, involving238,455patients.The threshold effect among the included literatures was r=0.745(P=0.013).The literatures were divided into a group of developing-country and a group of developed-country according to the results of meta-regression analysis.Of the group of developing-country,the pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,AUC value and Q index were 0.73(95%C/=0.66-0.79),0.81(95%CZ=0.80-0.83),3.19(95%CZ=2.15-4.72),0.34(95%CZ=0.21-0.54),10.45(7.03-15.50)0.83 and0.77,respectively.Of the group of developed-country,the AUC value and Q index were0.716and0.666,respectively.Conclusion[基金项目]*本课题为中国医科大学社科项目,项目编号为XRW20160001;中国医科大学护理学院基金项目,项目编号为2019HL-19o[收稿日期]2020-10-07[作者简介]唐文(1995-),女,四川江油人,硕士在读,主要从事老年护理、社区护理工作。
NSS42015听力真题
NSS42015听力真题Conversation 11. Why does the student go to see the professor? [单选题] *A. To get a copy of a literary magazineB. To discuss a poem he read for classC. To find out about getting an essay published(正确答案)D. To ask about an essay writing assignment.2. What does the professor imply about submissions to the editorial board? [单选题] *A. Most of them are original works of poetry.B. Most of them are from English majors.C. They will not all be published.(正确答案)D. They must be made online.3. Why does the professor mention another student's essay? [单选题] *A. To let the student know that he cannot write about a similar topicB. To give the student other ideas for his essayC. To inform the student that he will be competing with many other studentsD. To encourage the student to submit his essay.(正确答案)4. How does the professor suggest the student adjust the content of his essay? [单选题] *A. By limiting his research to a small sample of poemsB. By comparing modern poems with traditional poems(正确答案)C. By focusing more on traditional poems than on modern poemsD. By including poems from several Native American communities5. What does the professor suggest the student look for in his analysis of the poems? [单选题] *A. Elements of spoken language(正确答案)B. The grandfather's role in the communityC. The author's attitude toward the subject matterD. The use of Native American myths.Lecture 1 theater6. What is the lecture mainly about? [单选题] *A. Changes in set designs in the United States during the nineteenth and early twentieth centuries(正确答案)B. Changes in approaches to set design that have influenced the subject matter of playsC. Characteristic elements of set designs in plays with domestic settingsD. Differences between set designs in the United States and set designs in Europe.7. What makes box sets distinct from other types of theatrical sets? [单选题] *A. They were originally developed by Shakespeare's theater company.B. They are used primarily in productions of ancient Greek plays.C. They are designed to simulate every aspect of an interior room.(正确答案)D. They are easily constructed and taken down.8. Why does the professor mention a French palace? [单选题] *A. To identify where the first box set was used in a playB. To illustrate the emphasis that some set designers placed on including accurate details(正确答案)C. To contrast French stage design with American stage designD. To point out that not all nineteenth-century productions were presented in theaters.9. What is the professor's opinion of elaborate stage sets? [单选题] *A. They can be suitable for certain kinds of productions.(正确答案)B. They often do not seem realistic.C. They should be used more often.D. They make it difficult for actors to do their jobs.10. According to the professor, what resulted from the practice of staging Shakespeare's plays as they had been staged in Shakespeare's own time? [单选题] *A. Anew emphasis on realism in theaterB. A new interest in plays based on historical eventsC. Greater expenses for theater companiesD. More frequent use of simple sets.(正确答案)11. What were two traits of nineteenth-century productions done in the ancient Greek style?Click on 2 answers. *A. Sets contained few, if any, props.(正确答案)B. Movement was more important than dialogue.C. Costumes were updated to interest modern audiences.D. Actors wore masks on stage.(正确答案)Lecture 2 Biology12. What is the purpose of the lecture? [单选题] *To describe two types of symbiosis found among ocean animalsTo describe a useful property of a bacterium(正确答案)To explain how certain bacteria can transfer genes from animals to plantsTo explain how Vibrio fischeri glow in the dark.13. Why does the professor mention termite digestion and the synthesis of vitamin K in humans? [单选题] *A. To contrast two very different types of symbiosisB. To explain that symbiosis is not limited to sea creaturesC. To stress how complex humans are compared to termitesD. To emphasize that symbiotic relationships are quite common.(正确答案)14. How does the symbiotic relationship with Vibrio fischeri benefit the angler fish? [单选题] *A. lt helps the angler fish to disguise itself from predators.B. lt helps the angler fish to see in the dark.C. lt helps the angler fish to attract prey.(正确答案)D. lt helps the angler fish to digest food.15. According to the professor, how does the bobtail squid avoid predators? [单选题] *A. lt uses an internal organ to illuminate itself.(正确答案)B. lt uses a symbiotic bacterium to change its color during the day.C. lt only comes out on moonless nights.D. lt stays in shallow areas where its predators cannot swim.16. What is the connection between Vibrio fischeri and transgenic technology? [单选题] *A. Vibrio fischeir's ability to live in symbiosis with other creatures inspired transgenic technology.B. Transgenic technology makes it possible to study the symbiosis of Vibrio fischeri with other organisms.C. Genes from Vibrio fischeri were the first to be used in experiments using transgenic technology.D. Genes from Vibrio fischeri can confirm the success of experiments that use transgenic technology.(正确答案)17. Why does the professor say this: [单选题] *A. To remind students about a previous lecture about termitesB. To indicate how important it is for researchers to work with microbesC. To reinforce the point she just made about symbiosis(正确答案)D. To draw the students' attention to a new topic.Conversation 218. Why does the student go to see the woman? [单选题] *A. To ask how he could play a major part in the graduation ceremony(正确答案)B. To convince her that he should be chosen as a graduation speakerC. To determine the procedure he must follow to hire a speakerD. To discuss how to apply for a position after he graduates.19. Why does the woman mention the length of the speech? [单选题] *A. To reassure the student that he should not be nervousB. To emphasize that the speech should be well focused(正确答案)C. To imply that most speeches are too longD. To explain why working with a speech coach is required20. The woman mentions several documents that the student needs to submit along with his application form. Indicate which ones he needs to include.Just Choose the included ones*A transcript of his grades(正确答案)A letter of intent(正确答案)A resumeA copy of his speechTwo letters of reference(正确答案)21. What new information helps convince the man to apply to be the commencement speaker? [单选题] *A. He would get help practicing his speech.(正确答案)B. He would be allowed to write his own speech.C. His English professor will help choose the commencement speaker.D. Previous commencement speakers have obtained jobs as speech writers.22. Why does the student say this: [单选题] *A. To clarify his understanding of the application process(正确答案)B. To suggest a way to improve the quality of commencement speechesC. To indicate that he has already written a speechD. To remind the woman about a recent change to the application process.Lecture 3 Sonification of Solart Wind23. What does the professor mainly discuss? [单选题] *A. lssues that make data about solar wind difficult to analyzeB. Reasons why it is important to study solar windC. A recent discovery about the Sun's coronaD. A method used to represent large amounts of data about solar wind.(正确答案)24. According to the professor, what can result from a magnetic storm?Click on 2 answers. *A. People can lose access to electricity.(正确答案)B. Temperatures on Earth's surface can increase temporarily.C. Earth's magnetic field can be permanently altered.D. The orbits of satellites can be disrupted.(正确答案)25. What point does the professor make about scientific visualization? [单选题] *A. lt is not well suited to representing complex data.(正确答案)B. lt is a time-consuming way to depict astronomical data.C. lt is particularly useful when depicting data about astronomical phenomena.D. lt is the best tool for analyzing a large amount of information.26. Why does the professor mention seismic data from volcanoes? [单选题] *A. To remind his students of something they discussed in a previous classB. To emphasize that the sonification of data has been done before(正确答案)C. To mention an instance when sonification was used incorrectlyD. To give an example of a time when sonification allowed scientists to predict an event.27. According to the professor, how was the solar wind data sonified? [单选题] *A. By programming data about solar wind into a computer to generate new soundsB. By following an established set of rules used for sonifying dataC. By assigning different musical sounds to three variables that affect solar wind(正确答案)D. By using clicking sounds to represent solar wind data captured by satellites.28. What is the professor's opinion of sonification? [单选题] *A. lt will not be as useful as scientific visualization.B. lt is helpful only when combined with other forms of data.C. lt will probably lead to new discoveries in astronomy.(正确答案)D. Olt is likely to become a popular method for composing music.Conversation 329. What is the conversation mainly about? [单选题] *The way the student submits his assignmentsThe student's frustration with the bookstoreThe need to place a book orderThe availability of class materials(正确答案)30. Why does the student take his lab report to the professor's office? [单选题] *To tell the professor about a problem he had with an assistantTo find out whether he can submit a photocopied versionTo ask a question about an assignmentTo meet an assignment deadline(正确答案)31. What is the cause of the problem that some students are having? [单选题] * The bookstore was slow to submit an orderThe enrollment for one of their classes was larger than expected(正确答案) They have not been able to enroll in a class that is requiredWorkbooks were missing from their textbook packages32. What is the student's attitude toward the problem? [单选题] *He is confident that the professor can solve the problem.He is not certain that the professor understands the problem.He does not share the professor's concern about the problem.(正确答案)He is upset that the professor did not know about the problem.33. What does the professor think the bookstore staff should do? [单选题] * Make sure they order workbooks and textbook at the same timeCheck that the books they ordered are the most recent editionCheck that the publisher has filed the order for extra books(正确答案) OExtend the deadline for ordering booksLecture 434. What does the professor mainly discuss? [单选题] *Early advances in tool-making skills on the central East European PlainEvidence for the early migration of humans onto the central East European Plain(正确答案)Methods used to reconstruct the early migration paths of humansReasons for the disappearance of the Aurignacian culture at Kostenki35. Why does the professor mention an ivory carving of a human head found at theKostenkisite? [单选题] *To show that the early settlers of Kostenki possessed sophisticated toolsTo indicate that the Kostenki settlers brought raw materials with them from AfricaTo prove that trade existed between Kostenki and settlements in western EuropeTo reinforce the idea that the artifacts found at Kostenki were Aurignacian(正确答案)36. What point does the professor make about radiocarbon dating? [单选题] *lt is not a dependable tool for dating artifacts over a certain age.(正确答案)lt is the only reliable way to date organic materials like bone or ivory.lt has been used to contradict the claim that Kostenki was settled 45,000 years ago.lt has been used to confirm the date that a large volcano erupted in Italy37. How were archaeologists able to determine the minimum age of the Kostenki artifacts? [单选题] *From their proximity to the bones of certain animalsOFrom their location relative to a layer of ash(正确答案)From the discovery of tools near the siteFrom the style of personal ornaments found at the site38. Why does the professor mention the discovery of needles at Kostenki? [单选题] *To show that not all of the tools found at Kostenki were technologically advancedTo indicate a type of tool not found at other Aurignacian settlementsTo indicate that the Kostenki settlers were equipped to survive in a cold climate(正确答案)To provide a contrast between technological achievements and representational art39. What is the professor's opinion about early human migration to Europe? [单选题] * Humans first settled in a surprising location.(正确答案)Humans arrived in Europe later than previously thought.Humans preferred to migrate to cold climates.lt is impossible to date early human migration.。
晶状体囊袋张力环植入在高度近视眼白内障超声乳化吸除人工晶状体植入术中的应用价值
万方数据万方数据万方数据·206·人工晶状体和CTR的植入能减少术后晶状体虹膜隔的前后移动,减少通过液化玻璃对视网膜的冲击及牵拉,这样可以减少术后视网膜脱离的机会。
我们此次大样本的研究中,随访18个月仅有2只眼发生视网膜脱离,发生比例为0.36%,低于国内外学者报道水平,而且在我们的研究中,患眼随访18个月,A组中仅有2只跟发生视网膜脱离,而B组有9只眼眼发生视网膜脱离,两组的视网膜脱离发生率比较差异有统计学意义(I=3.05,P<0.01),从而提示了CTR对视网膜脱离的预防作用,不过今后还需大样本长期的观察才能得出最终的结论。
此外,值得一提的是,此次我们研究的549例患眼中,术后仅发现1例(1只眼)患者术后高眼压经保守治疗无法控制,以致最后不得不取出CTR眼压才得以降至正常。
我们怀疑囊袋张力环植入术后出现高眼压的可能原因为:(1)术后前房内粘弹剂存留;(2)与人工晶状体襻不同,CTR与囊袋呈360度广泛接触,因此选择直径过大的张力环术后可能对睫状体产生刺激导致房水生成增加;(3)因为高度近视,术中注入前房的粘弹剂可能通过松弛的悬韧带间隙进入后房,而当CTR植入后囊袋被拉紧,因此存留于后房的粘弹剂不易被吸出而导致眼压升高;(4)CTR对睫状体的刺激导致睫状体水肿使人工晶状体与睫状体的距离缩短,导致睫状环阻滞性青光眼。
我们怀疑该患者房水排流受阻部位处于睫状环区域,即睫状突与晶状体赤道部或玻璃体前界膜的同位接触或粘连,完整增厚的后囊膜、前界膜、CTR和人工晶状体,可能作为一个屏障阻碍了房水向前流动。
另外,此患者因高度近视,晶状体悬韧带松弛,可能使睫状突前旋,加上囊袋内植入CTR撑开囊袋,可能更加重了睫状突与晶状体赤道部的粘连,使房水前流受阻而逆流人玻璃体腔中,导致恶性青光眼发生u川。
参考文献[1]CiomuliJ,OdaerRtt.Fadoe聊utllrIilIgippmaelatOtheadd,ted∞柚啊c‘伽elens.JC.1araetR出met,su曙。
浪费水资源的英语报道作文
In recent years,the issue of water resource wastage has become a global concern. The following report delves into the various aspects of this critical problem,highlighting its causes,consequences,and potential solutions.Introduction to the IssueWater is a vital resource for life on Earth,yet it is being wasted at an alarming rate.From agricultural runoff to industrial discharges and household leaks,the misuse of water resources is rampant.This report aims to shed light on the gravity of the situation and the urgent need for collective action.Causes of Water Wastage1.Inefficient Irrigation Systems:Traditional irrigation methods,such as flood irrigation, often lead to significant water loss due to evaporation and runoff.ck of Infrastructure:In many regions,the absence of proper water management systems results in leakage and wastage.3.Industrial Overuse:Industries often use large volumes of water for cooling and processing,with inadequate recycling or treatment measures in place.4.Domestic Misuse:Everyday activities like overwatering gardens,long showers,and running taps unnecessarily contribute to water wastage.5.Poor Water Pricing Policies:In some areas,low water prices do not incentivize conservation,leading to overuse.Consequences of Water Wastage1.Environmental Impact:Wastage can lead to the depletion of aquifers,drying up of rivers,and the loss of biodiversity.2.Economic Loss:The economic cost of water wastage is substantial,affecting agriculture,industry,and municipal services.3.Social Implications:Water scarcity can lead to conflicts over resources,affecting community stability and wellbeing.4.Health Risks:Contaminated water from improper disposal can lead to waterborne diseases,impacting public health.Potential Solutions1.Promoting WaterEfficient Technologies:Encouraging the use of drip irrigation and smart watering systems can significantly reduce agricultural water use.2.Upgrading Infrastructure:Investing in modern water supply and distribution systems can minimize leakage and improve efficiency.3.Regulatory Measures:Implementing stricter regulations on industrial water use and enforcing penalties for noncompliance can curb wastage.4.Public Awareness Campaigns:Educating the public about the importance of waterconservation and promoting watersaving practices at home.5.Economic Incentives:Introducing tiered pricing for water usage can encourage users to reduce consumption.ConclusionThe wastage of water resources is a pressing issue that demands immediate attention.By understanding the causes and consequences,and by implementing effective solutions,we can work towards a more sustainable use of water.It is crucial for governments, industries,and individuals to take responsibility and contribute to the preservation of this precious resource.Call to ActionAs we conclude this report,it is essential to call upon all stakeholders to take proactive steps in reducing water wastage.From implementing technological advancements to fostering a culture of conservation,every effort counts towards ensuring a watersecure future for generations to come.。
百人计划终期评估优秀奖 英文
Overall, the Hundred People Program was a valuable experiment that provided important insights into theeffects of providing financial assistance to low-income families. The program's findings have been used to inform policy decisions at both the state and federal levels.
百人计划终期评估优秀奖
英文回答:
The Hundred People Program was a groundbreaking initiative designed to study the long-term effects of providing financial assistance to low-income families. The program, which ran from 1968 to 1982, randomly assigned families to one of three groups: atreatment group that received a guaranteed annual income, a control group that received no financial assistance, and a comparison group that received a modest amount of financial assistance.
成人郎格汉斯细胞组织细胞增生症1例报告及文献复习
成人郎格汉斯细胞组织细胞增生症1例报告及文献复习温泉;王园园;司鹤南;田亚萍【摘要】Objective:To study the clinical and pathological features of Langerhans cell histiocytosis (LCH), and to provide the reference for its diagnosis and treatment.Methods:The manifestation of one LCH patient was retrospectively analyzed.The features of the LCH patients were explored by analyzing the results of skin biopsy, radiological test and follow-up.The associated literatures were reviewed.Results:The patient presented the typical symptoms gradually,including polycystic lung,skin ulcer,diabetes insipidus,and lactation.The skin pathological findings showed the densely distributed mononuclear cell infiltration in dermis and the immunohistological staining result showed positive CD1a. The patient was follwed up for 7 years and died of heart and lung failure. Conclusion:LHC has various manifestations and should be confirmed by clinical features,pathological features and imaging examination.The adult patients with multisystem and vital organ involvement suggest the poor prognosis.%目的:探讨郎格汉斯细胞组织细胞增生症(LCH)的临床和病理特征,为其诊治提供参考。
无热子空心阴极内中性气体分布的数值模拟研究
无热子空心阴极内中性气体分布的数值模拟研究董小敏;李娟;陈娟娟【摘要】The distribution of neutral propellant gas pressure in the heaterless cathode,especially the region which along the cathode tip to keeper,is important to the ignition voltage value. In this paper,the pressure and velocity distribu-tion before the ignition of heaterless cathode were simulated by the FEA method and high Mach number compressible flu-id model. The result is indicated that the neutral gas pressure along the cathode tip and keeper was related sensitively to the keeper orifice diameter and it was effect weakly by the cathode tip orifice diameter and the spacing along the tip and keeper. But the ignition voltage of heaterless cathode will be affected by the spacing along the electrode according to the Paschen's law. The result of this paper demonstrates that key factors of influences the breakdown voltage of heaterless cath-ode are keeper orifice diameter and spacing along the tip and keeper when the propellant is not changed. That would be given some references when developing the simulation model of hollow cathode or the design of a new heaterless cathode.%无热子空心阴极内部中性气体压力分布,特别是阴极顶与触持极间的压力分布,对其点火启动电压有较大影响。
anhydrous for analysis emsure -回复
anhydrous for analysis emsure -回复Anhydrous for Analysis EMSURE: Understanding Its Importance and ApplicationsIntroduction:Anhydrous for Analysis EMSURE is a high-quality reagent widely used in various scientific disciplines and industries. It plays a crucial role in ensuring accurate and reliable analytical results. In this article, we will explore in detail the significance, properties, and applications of Anhydrous for Analysis EMSURE, thereby providing a comprehensive understanding of this essential reagent.1. What is Anhydrous for Analysis EMSURE?Anhydrous for Analysis EMSURE is a term used to describe a broad range of reagents that are completely free from water molecules. These reagents are produced using advanced techniques to remove any moisture content, ensuring maximum stability and purity. Anhydrous for Analysis EMSURE is typically available in ultra-pure forms, meeting the highest quality standards demanded by analytical laboratories.2. Importance of Anhydrous for Analysis EMSURE:2.1. Eliminating Water Interference:Water is a common impurity in many chemicals used in analytical processes. However, the presence of water can interfere with various reactions and measurements, leading to inaccurate results. Anhydrous for Analysis EMSURE eliminates this interference, allowing for precise and reliable analysis.2.2. Enhanced Stability:Water can initiate degradation processes in certain substances, affecting their stability over time. Anhydrous for Analysis EMSURE, being entirely free from water, exhibits superior stability and prolonged shelf life. This property is especially critical for long-term storage of reagents and standards.2.3. Prevention of Hydrate Formation:Certain compounds readily react with water, forming hydrates—a chemically combined form where water molecules are incorporated into the substance's crystal lattice. Anhydrous for Analysis EMSURE prevents hydrate formation, maintaining the integrity of thecompound and ensuring accurate analysis.3. Properties of Anhydrous for Analysis EMSURE:3.1. Low Water Content:Anhydrous for Analysis EMSURE reagents typically have an extremely low moisture content, often in the range of parts per million (ppm) or below. This ensures minimal water-related interference during analytical procedures.3.2. High Purity:To meet the stringent requirements of analytical applications, Anhydrous for Analysis EMSURE reagents are manufactured to possess high purity levels. They undergo rigorous quality control measures, including multiple purification steps, to eliminate impurities that could affect the accuracy of analytical results.3.3. Traceable Certification:Anhydrous for Analysis EMSURE reagents are accompanied by comprehensive certificates of analysis, detailing the quality, purity, and conformity of the product. These certificates provide traceability and help maintain consistency in analytical procedures.4. Applications of Anhydrous for Analysis EMSURE:4.1. Chemical Analysis:Anhydrous for Analysis EMSURE reagents are widely used in various chemical analyses, including titrations, spectrophotometry, chromatography, and atomic absorption spectroscopy. Their water-free nature ensures accurate measurements and consistent results.4.2. Pharmaceutical Industry:In the pharmaceutical industry, Anhydrous for Analysis EMSURE is invaluable for conducting quality control tests, formulation development, and stability studies. It helps ensure the purity and stability of drug substances and excipients, thus contributing to the production of safe and effective medications.4.3. Food and Beverage Industry:Anhydrous for Analysis EMSURE reagents find extensive utility in the food and beverage industry. They are employed for the analysis of food components, additives, and contaminants, ensuring compliance with regulatory standards and ensuring consumersafety.4.4. Environmental Analysis:In environmental analysis, Anhydrous for Analysis EMSURE reagents aid in monitoring pollution levels, assessing the quality of water and air, and investigating the impact of pollutants on the environment. The absence of water interference allows for precise measurements and reliable data.5. Conclusion:Anhydrous for Analysis EMSURE is an indispensable reagent that plays a vital role in ensuring accurate and reliable analysis across various scientific disciplines and industries. Its ability to eliminate water interference, enhance stability, and prevent hydrate formation makes it a preferred choice for a wide range of applications. By understanding the significance and properties of Anhydrous for Analysis EMSURE, researchers and analysts can confidently employ this high-quality reagent to obtain precise and consistent results.。
A_Review_of_Recently_Approved_PD-1_Inhibitors_for_
A Review of Recently Approved PD-1 Inhibitors for the Treatment of Gastric CancerKeru ChenCollege of Life Science of Sichuan Agricultural University, Ya'an Sichuan 625014, P.R. China ABSTRACTGastric cancer is a formidable adversary in the realm of human health,posing a serious threat to those who are afflicted by it. However, there ishope on the horizon as research into its treatment has been progressingsteadily in recent years. Up to now, there are three kinds of immunecheckpoint inhibitors approved by NMPA that can be used in treatingGastric cancer, all of which target PD-1. They are Sintilimab, Tislelizumab,and Nivolumab. While they share similarities in their approach tocombating gastric cancer, there are also notable differences betweenthem that warrant closer examination. This review highlights the cost-effectiveness of Sintilimab and Tislelizumab compared with Nivolumab.By analyzing these differences more closely, we can gain valuable insightsinto which drug may be most suitable for individual patients based ontheir unique circumstances. And with continued progress in this field, wecan look forward to even more effective treatments being developed thatwill help us overcome this challenging disease once and for all.KEYWORDSPD-1 inhibitors; Gastric cancer; Nivolumab; SintilimabDOI: 10.47297/taposatWSP2633-456915.202304011 IntroductionHuman health is seriously threatened by gastric cancer, one of the world's most common forms of malignant tumor. IARC reported 1089103 new cases of gastric cancer worldwide in 2020, which accounts for 5.6% of all new tumors. And the incidence rate among males is more than double that of females. Aging and population growth are expected to significantly increase new cases and deaths of GC despite declining incidence and mortality rates [1].In addition to starting in the stomach, gastric cancer can spread to the esophagus and small intestine. It can also spread to nearby organs and lymph nodes. Almost all gastric malignancies are adenocarcinomas, which refer to adenocarcinomas of the stomach. Early gastric cancer typically presents with no symptoms or signs, making early detection challenging. Advanced-stage diagnosis is common in gastric cancer (80-90%), and 30% miss out on radical surgery, with frequent recurrence within 5 years post-surgery. There is an urgent need for research into treatments.A Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo in 2018. This was for their discovery of cancer therapy by inhibiting the negative immune system. Then we saw a breakthrough milestone has been reached in tumor therapy with immunotherapy. In recent years, the research of immune checkpoints has developed rapidly as one of the most promising immunotherapy strategies for treating malignant tumors.Theory and Practice of Science and TechnologyTumor cells can be distinguished from normal cells by the immune system using the myriad of genetic and epigenetic changes that are unique to all cancers. Through antigen-specific signals from TCRs as well as antigen-independent signals from cosignaling receptors, T-cells will be activated, followed by cosigning receptors on their surface: costimulatory receptors and coinhibitory receptors, whose functions are essential to T cell signaling and activation.[2].T cells are influenced by co-signaling molecules. Over-expression of programmed death-1 (PD-1) may contribute to immune evasion in cancer patients, suggesting the potential for immune checkpoint inhibitors in the treatment of gastric cancer. Additionally, the possibility of immunotherapy as a first-line treatment option for gastric and gastroesophageal adenocarcinomas could be offered by these two randomized trials presented at ESMO 2020 [3].In contrast to traditional therapies that target cancer cells, immune checkpoint therapy activates the body's immune system which has been suppressed by tumors to eliminate cancer cells. Due to GC’s high heterogeneity and complex molecular mechanism, it is still of research significance for the selection of treatment methods for different types of gastric cancer. Immune checkpoint therapy, considered a targeted treatment, can also be a more appropriate treatment.PD-1/PD-L1 immune drugs have been widely commercialized in China in just five years since they were first approved in June 2018. According to the NMPA, 17 immune checkpoint inhibitors are available on the Chinese market. In addition, three immune checkpoint inhibitors have been approved for gastric cancer treatment: Nivolumab, Tislelizumab, and Sindillimab. This review may get a relatively better treatment option by comparing the differences between the three drugs.Table 1. Three clinic indications of PD-1 mAbs approved for gastric cancer listed in ChinaTarget Structure Agent indicationsPD-1Nivolumab( Opdivo®)Lung cancer, SCCHN, gastric or gastro-oesophageal junction cancer,malignant pleural mesothelioma, advanced or metastatic gastric cancer,esophageal cancer or esophagogastric junction cancer, advanced ormetastatic esophageal squamous cell carcinomaPD-1Sintilimab(Sintilimab Injection)Hodgkin's lymphoma, lung cancer, liver cancer, esophageal cancer, gastric orgastro-oesophageal junction cancerPD-1Tislelizumab(Tislelizumab Injection)Hodgkin's lymphoma, lung cancer, liver cancer, MSI-H/dMMR SolidTumor, esophageal cancer, nasopharyngeal carcinoma, gastric or gastro-oesophageal junction cancer2 Approved PD-1 Monoclonal Antibodies in Gastric CancerIn peripheral tissues, the PD-1/PD-L1 checkpoint is functional and a negative regulator of T cells, both with regards to regulating local inflammatory responses and maintaining self-tolerance.[4]. PD-1 is expressed in T cells, natural killer cells, and B cells of the immune system.PD-1 intracellular domains contain two separate phosphorylation sites in both their N- and C-terminal amino acid residues: immunoreceptor tyrosine-based switch motif (ITSM) and immunoreceptor tyrosine inhibition motif (ITIM). Among these structural sites, ITSM plays an essential role in PD-1's biological actions: it is phosphorylated when PD-1 binds to PD-L1, resulting in the activation of a number of intracellular signaling pathways and effective immunosuppression[5].There are two types of PD-1 Ligands, which are PD-L1 and PD-L2. Although the interaction of PD-L2 and PD-1 can inhibit T-cell effector function, PD-L2 is expressed less than PD-L1, with expression in macrophages and dendritic cells. In this way, PD-L1 seems to be more effective and widely expressed,Vol.4 No.1 2023suggesting a more prominent role for it in the regulation of peripheral T-cell responses [6].Figure 1. Antibodies against PD-1 inhibit the function of the brake leading to activation of T cells and highly efficientattack on cancer cells the from 2018 Nobel Prize in Physiology or Medicine(1) NivolumabThe anti-PD-1 antibody Nivolumab belongs to the family of IgG4 monoclonal antibodies. It is a monoclonal antibody jointly developed by two companies named Ono Pharmaceutical (Ono) and Bristol-Myers Squibb (BMS). It functions on T cells by binding to the PD-1 protein. This prevents cancer cells from suppressing the immune system. Thus, cancer cells can be attacked by the immune system.1) Nivolumab plus chemotherapyAn international, randomized, CheckMate 649 phase 3 study found that Combining Nivolumab with chemotherapy significantly enhanced overall survival compared to chemotherapy when treating gastric, gastro-esophageal junction, or esophageal cancers. A 30% reduction in mortality is achieved, with a 31% versus 19% survival rate at 24 months. This outcome has led many countries, including China, to approve Nivolumab plus chemotherapy as the primary therapy for these patients.2) Nivolumab plus ipillimumabCombination therapy simultaneously targeting PD-1 and CTLA-4 immune checkpoints made remarkable and efficient effects on antitumor. The research shows that the blockade of each immune checkpoint or the combination of the two has distinct but complementary mechanisms of action.As shown in the Checkmate-032 study, Nivolumab plus ipilimumab was effective against chemotherapy-refractory esophagogastric cancer and had durable responses, long OS periods, and manageable safety. It was also reported that overall survival was lower for patients who received ipillimumab plus nivolumab (combination of PD-L1 positive scores ≥ 5) than for patients who received only chemotherapy. In order to treat gastroesophageal adenocarcinoma effectively, nivolumab plus chemotherapy should be the standard first-line treatment.Theory and Practice of Science and Technology3) PriceNivolumab has different specifications and prices: 100mg/10ml CNY 9260 and 40mg/4ml CNY 4591. According to BMS, nivolumab is used for intravenous Opdivo 3mg/kg every two weeks. Dosage is related to body weight.(2) TislelizumabTislelizumab, a humanized monoclonal antibody directed against PD-1, demonstrates high affinity and specificity.It is well documented that tislelizumb has longer t1/2 and slower dissociation rate from PD-1 than nivolumab[7], showing a hidden mechanism for clearing T cells and resisting anti-PD-1 treatments.1) Tislelizumab plus chemotherapyIn a phase II clinical trial (NCT03469557), tislelizumab plus chemotherapy was evaluated in patients with localized or metastatic G/GEJ adenocarcinoma. A study found that Tislelizumab plus chemotherapy achieved durable responses and was safe for patients without new safety signals. NACT plus tislelizumab has improved LAGC efficacy and R0 resection rate without causing perioperative complications in recently published studies. And Another phase II clinical trial(NCT03469557[8]) demonstrated that tislelizumab together with chemotherapy could control adverse events associated with advanced G/GEJ adenocarcinomas in the first-line treatment showing the possibility of this combination therapy.2) PriceOn March 1, 2021, after the official implementation of national medical insurance, the price of tislelizumab was reduced to CYN 2180 per tube (100mg), a reduction of up to 80%, and the down payment for self-paid treatment was only CYN 4360 per cycle, which is in the low-price range among immunological drugs of the same specification.(3) SintilimabThe recombinant anti-PD-1 antibody sintilimab has a higher affinity than both nivolumab and pembrolizumab.Sintilimab could bind to human PD-1 strongly and specifically. A powerful antitumor effect was observed along with a high level of tumor-infiltrating CD8/CD4 T cells and CD8/Treg ratios. In addition, it can block PD-1 interaction with PD-L1 and PD-L2, elevate interferon (IFN)-γ and interleukin (IL)-2, and increase anticancer activity. There are several combination therapies.1) Sintilimab plus chemotherapyPFS was significantly prolonged by PD-1 inhibitors plus oxaliplatin-based chemotherapy but did not prolong OS statistically significantly when compared to PD-1 inhibitors plus cisplatin. Combining PD-1 inhibitors with oxaliplatin-based chemotherapy may represent a superior first-line treatment option for AGC both As far as efficacy and safety are concerned [9], especially for patients with CPS ≥ 1. In comparison with The combination of sintilimab and oxaliplatin, nivolumab plus oxaliplatin did not show a significant difference.Vol.4 No.1 20232) Sintilimab plus oxaliplatin/capecitabineDuring a phase Ib clinical trial, Sintilimab plus CapeOx demonstrated promising outcomes in treating advanced or metastatic G/GEJ adenocarcinomas[10]. However, Currently, the Phase III clinical trial is being conducted on a large, randomized, double-blinded scale because of the small sample size.We still know that multiple advantages can be gained by delivering neoadjuvant therapy to patients with G/GEJ adenocarcinomas beyond surgery alone. In neoadjuvant settings, sintilimab plus oxaliplatin/capecitabine showed encouraging efficacy and safety profile[11].3) PriceAfter 2022, Sintilimab began to implement the latest price of CYN 1080 per unit (100mg) in China. Until disease progression or intolerable toxicity occurs, 200 mg is recommended every 3 weeks.3 ConclusionThis paper has given three different approved PD-1 mAbs in China that can be used in the treatment of G/GEJ cancer and showed the recent combination therapy used recently. Although α - PD-1/PD-L1 therapy has shown strong anti-tumor effects in some patients, due to primary or acquired treatment resistance, most patients cannot benefit from α- PD-1/PD-L1 treatment.Compared with monotherapy, combination therapy has better anti-tumor effects, OS, and other advantages, and its adverse resolution is within the controllable range. The most used combination therapy is chemotherapy and in combination with other immune checkpoint inhibitors that have increased its effectiveness.As a drug with a long research period, Nivolumab has many related research trials showing that the combination with chemotherapy is safer and more controllable than in combination with CTLA-4 inhibitors and is more suitable as the main first-line treatment. For the latter two drugs, although showing controllability and safety, the research is still temporarily stuck in combination with chemotherapy, due to various reasons, further trials are needed to obtain more accurate data.Considering the cost, it is noteworthy that except for Nivolumab, both other two approved drugs have been incorporated into China's medical insurance system and their prices have been significantly reduced even without insurance coverage. In summary, the research of the three drugs on the market still needs to be strengthened, among which most of the effects of Sintilimab and Tislelizumab are better than nivolumab and more cost-effective, but their studies need to be continuously expanded to determine their safety and efficacy.Table 2. Price comparison of three drugsAgent Nivolumab Sintilimab TislelizumabPrices in China CNY 9260/100mgCNY 4591/40mgCYN 2180/100mg CYN 1080/100mgRecommended dose3 mg/kg is givenintravenously every 2 weeksfor 60 minutes until diseaseprogression or unacceptabletoxicityThe recommended doseis 200 mg every 3 weeksuntil disease progression orintolerable toxicity.It is given intravenously at arecommended dose of 200mg every 3 weeks.Theory and Practice of Science and TechnologyAbout the AuthorKeru Chen is undergraduate of School of Life Science, Sichuan Agricultural University, and her research field is biology.References[1] Yan, C., Shan, F., Ying, X., Li, Z. (2023). Global burden prediction of gastric cancer during demographic transition from2020 to 2040. Chin. Med. J. (Engl.), 136: 397–406.[2] Hui, E., Cheung, J., Zhu, J., et al. (2017) .T cell costimulatory receptor CD28 is a primary target for PD-1-mediatedinhibition. Science, 355: 1428-+.[3] Smyth, E.C., Cervantes, A. (2020) .Addition of nivolumab to chemotherapy in patients with advanced gastric cancer: arelevant step ahead, but still many questions to answer. Esmo Open, 5: e001107.[4] Sunshine, J., Taube, J.M. (2015). PD-1/PD-L1 inhibitors. Curr. Opin. Pharmacol. 23: 32–38.[5] Hofmeyer KA, Jeon H, Zang X. (2011) The PD-1/PD-L1 (B7-H1) Pathway in Chronic Infection-Induced Cytotoxic TLymphocyte Exhaustion. J. Biomed. Biotechnol., 451694.[6] Sundar, R., Cho, B.C., Brahmer, J.R., et al. (2015) .Nivolumab in NSCLC: latest evidence and clinical potential. Ther. Adv.Med. Oncol., 7: 85–96.[7] Hong, Y., Feng, Y., Sun, H., et al. (2021). Tislelizumab uniquely binds to the CC’ loop of PD-1 with slow-dissociated rateand complete PD-L1 blockage. FEBS Open Bio, 11: 782–92.[8] Qiu, H.B. (2020). Safety and efficacy of tislelizumab plus chemotherapy for first-line treatment of advanced esophagealsquamous cell carcinoma and gastric/gastroesophageal junction adenocarcinoma. Thorac. Cancer, 11: 3419–21. [9] Guo, X., Yang, B., He, L., et al. (2022). PD-1 inhibitors plus oxaliplatin or cisplatin-based chemotherapy in first-linetreatments for advanced gastric cancer: A network meta-analysis. Front. Immunol., 13: 905651.[10] Jiang, H., Zheng, Y., Qian, J., et al. (2020). Safety and efficacy of sintilimab combined with oxaliplatin/capecitabine asfirst-line treatment in patients with locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma in a phase Ib clinical trial. BMC Cancer, 20: 760.[11] Jiang, H., Yu, X., Li, N., et al. (2022). Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine inpatients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early results of a phase 2 study. J. Immunother. Cancer, 10: e003635.。
荷尔登生物医学检测产品说明书
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Order of Draw: 1. BLOOD CULTURES 2. LT BLUE 3. RED 4. SST 5. PST/LH GRN 6. LAV 7. GRAY
M2909 (1-19)
Microtainer Microtainer 1 mL
2 Microtainers Microtainer
2 mL FILL TO LINE 1 mL 1 mL Microtainer 1 mL 1 mL Microtainer
SST, R, GL
STAT to lab in 10 min
Also known as CMP SST, R, GL SST, R, GL
TOBRAMYCIN TOTAL PROTEIN TROPONIN TSH
TYPE AND CROSSMATCH
TYPE AND SCREEN URIC ACID
VANCOMYCIN VALPROIC ACID VITAMIN D
FEA
6LA LHC 6LIP
6LIVER 6LIPID LIA 6MG 6METX 6MONO PHNOC 6PFA 6PHOS 6PBNP 6PCAL 6KA 6PTIMEN PSAC 6PTT 6RETCT 6RENAL WHRIG 6SAL SYPHB TBSATA TT3C T4C TESTOC THEOC
CHEM8
QUICK CHEM 8 CBC/AUTO DIFF CKMB
COMP CREATININE CREATININE X-RAY EVALUATION D-DIMER DIGOXIN DILANTIN ELECTROLYTES FERRITIN FSH GLUCOSE
acs catalysis 显示under review -回复
acs catalysis 显示under review -回复ACS Catalysis is a highly reputable scientific journal that publishes cutting-edge research in the field of catalysis. As a catalysis enthusiast, I was thrilled to come across an article with the intriguing title "[ACS Catalysis Under Review]." In this article, I will take you on a journey through the various stages of the review process for an ACS Catalysis publication, providing insights into the significance of each step and the role it plays in ensuring the quality and importance of the research being considered for publication.The initial stage of the review process begins once an author submits their research article to ACS Catalysis for consideration. The article undergoes an initial screening process by the journal's editorial team, who evaluate its suitability for the journal based on its scope, significance, and adherence to the journal's guidelines. Factors such as the novelty of the research, its relevance to the field of catalysis, and the clarity and integrity of the data presented are all taken into consideration during this screening stage. This ensures that only high-quality research articles are considered for further review, maintaining the journal's reputation for publishing impactful research.Following the initial screening, the article is then assigned to one or several expert reviewers who have in-depth knowledge and expertise in the particular field of the research. The reviewers are chosen based on their previous publications and their standing in the scientific community. They play a critical role in assessing the scientific rigor of the research, its originality, and its potential impact on the field. The reviewers meticulously analyze the article, paying close attention to the experimental design, methodologies, results, and conclusions. They also evaluate the clarity and coherence of the manuscript, ensuring that it is well-written and easily understandable to the scientific community.The review process typically involves two or more rounds of feedback and revision between the authors and the reviewers. The first round of reviews may bring forth suggestions for improvements, additional experiments, or clarifications needed in the manuscript. The authors carefully consider these suggestions and provide a detailed response, addressing each point raised by the reviewers. The authors may also revise their manuscript based on these suggestions and provide a revised version along with the response letter.Once the revised manuscript is resubmitted, it undergoes a second round of review. Here, the reviewers examine the revisions and determine if the authors have adequately addressed the concerns raised during the first round of review. The reviewers evaluate the revised manuscript, paying close attention to the changes made, and whether they have strengthened the research and addressed any methodological or conceptual issues. The second round of review is crucial in ensuring that the final manuscript meets the high standards set by ACS Catalysis.After the second round of review, the reviewers provide their final recommendations to the journal's editor-in-chief. Based on these recommendations, the editor-in-chief makes the ultimate decision of whether to accept the manuscript for publication, reject it, or request further revisions. This decision is made with the goal of publishing only impactful and scientifically sound research in ACS Catalysis. The decision-making process takes into account the reviewer's assessments, the overall significance of the research, and its potential contribution to the field of catalysis.In conclusion, the review process for ACS Catalysis publicationsinvolves a meticulous and rigorous evaluation of research articles by experts in the field. The process ensures that only high-quality, impactful research is published, and that the published articles contribute to the advancement of the field of catalysis. By understanding the steps involved in the review process, we gain a deeper appreciation of the immense effort and expertise required to produce reputable scientific publications like those seen in ACS Catalysis.。
bioactive materials under review -回复
bioactive materials under review -回复"Bioactive Materials Under Review: Unlocking Potential for Health Innovation"Introduction:Bioactive materials have gained significant attention in the field of healthcare and medicine in recent years. These cutting-edge materials possess unique properties that allow them to interact with biological systems, promoting healing and tissue regeneration. As researchers continue to explore the potential applications of bioactive materials, it is crucial to understand the concept of bioactivity, the mechanisms involved, and the current status of this field.1. What are bioactive materials?Bioactive materials are substances that have the ability to interact with living tissue, promoting specific biological responses. Unlike traditional inert materials, bioactive materials actively interface with the body to induce desired reactions. This interaction can be achieved through different means, including chemical, biological,or mechanical signaling.2. How do bioactive materials work?Bioactive materials utilize various mechanisms to induce their effects. One common approach is through the release of bioactive molecules, such as growth factors or drugs, which stimulate cellular responses. Another strategy involves the modification of the material's surface, allowing for enhanced cell adhesion, proliferation, and differentiation. The integration of bioactive materials with host tissue through biomineralization is yet another mechanism by which they can promote tissue regeneration.3. Promising applications of bioactive materials:a. Bone regeneration: Bioactive materials, such as hydroxyapatite and bioactive glasses, have shown great potential in the repair and regeneration of bone tissue. These materials can provide structure, promote cell attachment, and stimulate bone formation, making them effective tools for treating fractures, defects, and diseases like osteoporosis.b. Dental restoration: Bioactive materials, like bioactiveglass-ceramics, have revolutionized dental restoration. They possess the ability to bond with natural tooth structures, reducing the risk of secondary decay and improving the longevity of dental restorations.c. Wound healing: Bioactive dressings, made from materials like collagen or chitosan, have shown promising results in promoting wound healing. These dressings can create an optimal environment for cell growth, angiogenesis, and tissue regeneration, accelerating the healing process.4. Challenges and future prospects:Despite the significant progress made in the development of bioactive materials, several challenges must be addressed. Ensuring long-term stability, optimizing biocompatibility, and determining the ideal release kinetics of bioactive molecules are some key areas that require further investigation. Additionally, regulatory hurdles and cost-effectiveness are important aspects that influence the practical application of these materials in clinical settings.The future of bioactive materials holds tremendous potential. Researchers are actively exploring advanced techniques such as 3D printing, nanotechnology, and surface engineering to further enhance the properties and functionality of bioactive materials. As understanding grows and technological advancements continue, bioactive materials have the potential to revolutionize personalized medicine, tissue engineering, and regenerative therapies.Conclusion:Bioactive materials represent a promising avenue for innovation in healthcare and medicine. These materials' ability to actively interact with biological systems opens up new possibilities for tissue regeneration, personalized medicine, and the treatment of various diseases. As researchers continue to explore their potential applications and overcome challenges, bioactive materials are poised to revolutionize the field, bringing us closer to a future of improved health outcomes and enhanced quality of life.。
2016年英语一text2
2016年英语一text2英文回答:In the provided text, the author examines the complex relationship between humans and machines, particularly in the context of artificial intelligence (AI). The author argues that as AI continues to advance, it is crucial for us to consider the potential consequences and implications for our society. Specifically, the author explores three main areas of concern: the economic impact of AI, the ethical implications of autonomous systems, and the long-term effects of AI on human identity and values.The author begins by discussing the economic impact of AI, arguing that while AI has the potential to create new jobs and increase productivity, it could also lead to job displacement and exacerbate economic inequality. The author acknowledges that the impact of AI on employment is complex and uncertain, but emphasizes the need for policymakers and businesses to proactively address the challenges andopportunities presented by AI.Next, the author examines the ethical implications of autonomous systems, such as self-driving cars and drones. The author argues that as AI becomes more sophisticated, we must confront the moral and ethical dilemmas that arise from delegating decision-making authority to machines. The author emphasizes the importance of ensuring that AI systems are developed and deployed in a way thatprioritizes human safety, privacy, and autonomy.Finally, the author explores the long-term effects of AI on human identity and values. The author argues that as AI becomes more pervasive in our lives, we may need to re-examine what it means to be human and what values we hold dear. The author raises questions about the potential for AI to shape our perceptions of reality, alter our social interactions, and influence our decision-making processes.Overall, the author provides a balanced and nuanced analysis of the complex relationship between humans and machines. The author acknowledges the potential benefits ofAI while also raising important concerns about itspotential consequences. The author concludes that it is crucial for us to approach the development and deploymentof AI with forethought and wisdom, ensuring that it serves the interests of humanity and aligns with our deepest values.中文回答:在这篇文章中,作者考察了人类和机器之间的复杂关系,尤其是在人工智能 (AI) 的背景下。
advances in higher education ssci -回复
advances in higher education ssci -回复Advances in Higher Education - The Impact of Social Sciences Citation Index (SSCI)Introduction:Higher education plays a crucial role in shaping individuals and societies, fostering economic growth, and driving innovation. As nations compete in a globalized knowledge economy, the quality and impact of research conducted in higher educational institutions become increasingly significant. The adoption and recognition of new evaluation metrics to measure scholarly impact and relevance have emerged as a critical topic in discussions about advances in higher education. The Social Sciences Citation Index (SSCI), a comprehensive citation index, has proven to be an invaluable tool in this regard. This article will explore the significance and implications of SSCI as a vital advancement in higher education, step by step.Step 1: Understanding the SSCIThe Social Sciences Citation Index, established in 1960, is part ofthe Web of Science database produced by Clarivate Analytics. Its primary purpose is to track citations of academic articles published in high-impact social science journals. SSCI functions as a comprehensive index that allows researchers, policymakers, and educators to assess scholarly impact, identify significant research trends, and evaluate the influence of academic journals within their respective fields.Step 2: Scholarly Impact MeasurementThe impact of scholarly research has traditionally been measured by publication count or the perceived prestige of the journal in which an article is published. However, these traditional metrics fail to capture the true impact and relevance of an individual article or a researcher's body of work. SSCI addresses this limitation by providing a more comprehensive picture of scholarly impact. By tracking citations, SSCI enables researchers and institutions to measure the influence and dissemination of academic work, providing a clearer understanding of how specific research publications have shaped subsequent research and influenced the scientific community.Step 3: Enhancing Research EvaluationThe inclusion of a journal or article in the SSCI is seen as a mark of distinction, indicating the research's quality and significance. Institutions worldwide have recognized the importance of SSCI in evaluating the research output of their faculty members, departments, and universities. This recognition has led to greater emphasis on publishing in SSCI-listed journals, fostering a culture of rigorous and impactful research within academia.Step 4: Identification of Research TrendsSSCI allows researchers and policymakers to identify prominent research trends within specific social science disciplines. By analyzing citation patterns and frequency, stakeholders can identify emerging issues, identify key contributors, and gain insights into research gaps. This information can guide decisions regarding the focus and allocation of research funding, facilitate interdisciplinary collaboration, and inform policymaking.Step 5: Influencing Policy and PracticeThe impact of research extends beyond academia, as it can influence policy decisions and shape practical applications. SSCI aids in identifying highly cited research that has had a significant impact on policy formulation, implementation, and evaluation. By providing policymakers and practitioners with access to influential research, SSCI facilitates evidence-based decision-making and enhances the translation of research findings into practical solutions.Step 6: Global Collaboration and Network BuildingAs SSCI enables researchers to identify and track influential scholars and institutions, it paves the way for global collaborations and network building. Researchers can connect with colleagues who share similar research interests, fostering exchange programs, joint publications, and research partnerships. Such collaboration transcends geographical boundaries, facilitating the exchange of knowledge and promoting cross-cultural understanding in higher education.Conclusion:The Social Sciences Citation Index (SSCI) has significantly advanced the evaluation, dissemination, and impact of research within higher education. By providing a comprehensive picture of scholarly impact, fostering rigorous research culture, and enabling global collaborations, SSCI has transformed the landscape of higher education. As we continue to strive for excellence and relevance in higher education, it is crucial to embrace and leverage advancements like SSCI to push the boundaries of knowledge and drive societal progress.。
hertzbeat 指标引用 -回复
hertzbeat 指标引用-回复Hertzbeat: An Essential Metric for Measuring Heart Health and FitnessIntroduction:In recent years, there has been a growing interest in monitoring and measuring heart health and fitness levels. One metric that has gained significant attention and importance in this field is hertzbeat. Hertzbeat is a metric that quantifies the number of times the heart beats per second, expressed in hertz. By measuring and analyzing hertzbeat, medical professionals and individuals can gain valuable insights into their cardiovascular health and fitness levels. In this article, we will delve into the significance of hertzbeat, its measurement methods, and how it can be used to assess heart health and fitness.1. What is hertzbeat?Hertzbeat refers to the frequency of heartbeats per second, measured in hertz. The term "hertz" is commonly used in physics and refers to the number of cycles per second. In the context ofheart health, hertzbeat represents the rate at which the heart contracts and expands within a given period.2. Why is hertzbeat important?Monitoring hertzbeat is crucial as it provides key information about heart health and fitness levels. The frequency at which the heart beats can indicate the efficiency of the cardiovascular system. A higher hertzbeat typically suggests a stronger and more efficient heart, whereas an irregular hertzbeat could be indicative of underlying heart conditions. Additionally, hertzbeat can also be used as an indicator of fitness levels, as regular exercise tends to improve heart efficiency and reduce resting heart rate.3. How is hertzbeat measured?Hertzbeat can be measured using various methods, each with its level of precision. Here are some common ways to measure hertzbeat:a. Pulse Oximeters: Pulse oximeters are devices commonly used to measure heart rate. They work by using a light source thatpenetrates the skin to detect the pulsations of blood vessels. This method provides an accurate and real-time measurement of heart rate, which can be converted into hertzbeat.b. ECG/EKG: Electrocardiography (ECG or EKG) is a non-invasive medical procedure that records the electrical activity of the heart. ECG machines can measure hertzbeat by analyzing the time intervals between individual heartbeats.c. Wearable Fitness Trackers: Many wearable fitness trackers, such as smartwatches, have built-in heart rate sensors. These devices use photoplethysmography (PPG) technology, similar to pulse oximeters, to measure hertzbeat. The measurements provided by these devices may not be as accurate as medical-grade equipment but are still useful for tracking heart health trends.4. Analyzing hertzbeat data:Once hertzbeat data has been collected, it can be analyzed to gain insights into heart health and fitness levels. Here are a few key metrics and trends that can be derived from hertzbeat analysis:a. Resting Heart Rate: This refers to the heart rate when the body is at rest. A lower resting heart rate generally indicates better cardiovascular fitness. Consistently high resting heart rates may signify underlying health issues.b. Heart Rate Variability (HRV): HRV measures the variations in time intervals between successive heartbeats. Higher HRV generally indicates better overall heart health and a more adaptable autonomic nervous system. Monitoring HRV can provide valuable information about stress levels and recovery.c. Exercise Intensity: By analyzing hertzbeat during physical activity, individuals can determine exercise intensity and adjust their workouts accordingly. This helps achieve optimal training zones for different health and fitness goals.5. Using hertzbeat to assess heart health and fitness:Hertzbeat analysis can be used to assess and track heart health and fitness levels. Regular monitoring of hertzbeat can help individuals and medical professionals identify potential heart conditions, track improvements in cardiovascular fitness, and adjust exerciseroutines for optimal benefits. By paying attention to hertzbeat trends over time, individuals can take proactive steps to maintain a healthy heart and improve overall fitness levels.Conclusion:Hertzbeat is a valuable metric in the assessment of heart health and fitness. By measuring and analyzing the frequency of heartbeats per second, individuals and medical professionals can gain important insights into cardiovascular health. With advancements in technology and the availability of wearable devices, hertzbeat monitoring has become more accessible to a wider population. Utilizing hertzbeat analysis can aid in the prevention, diagnosis, and management of heart-related conditions while promoting overall well-being.。
VITROS Anti
INSTRUCTIONS FOR USE CoV2G VITROS Immunodiagnostic ProductsAnti‑SARS-CoV-2 IgG Controls619 9921Rx ONLYIntended UseFor in vitro diagnostic and Laboratory Professional use.For use in monitoring the performance of the VITROS Immunodiagnostic and Integrated Systems when used for thedetermination of IgG antibodies to SARS-CoV-2.Warnings and PrecautionsWARNING:Potentially Infectious MaterialTreat as if capable of transmitting infection.Use caution when handling material of human origin. Consider all samplespotentially infectious. No test method can offer complete assurance that hepatitis Bvirus, hepatitis C virus (HCV), human immunodeficiency virus (HIV 1+2) or otherinfectious agents are absent. Handle, use, store and dispose of solid and liquidwaste from samples and test components, in accordance with procedures definedby appropriate national biohazard safety guideline or regulation (e.g. CLSIdocument M29). 1VITROS Anti‑SARS-CoV-2 IgG Controls 1 and 2 contain: SARS-CoV-2 IgGnegative matrix obtained from donors who were tested individually and who werefound to be negative for hepatitis B surface antigen, and for antibodies to hepatitisC virus (HCV) and HIV, using approved methods (enzyme immunoassays).VITROS Anti-SARS-CoV-2 IgG Control 2 in addition contains: SARS-CoV2 IgG. Notesting method can rule out the risk of potential infection, handle as if capable oftransmitting infection.WARNING:Contains ProClin 950 (CAS 2682–20–4) 2The VITROS Anti‑SARS-CoV-2 IgG Controls contain 0.5% ProClin 950. H317: Maycause an allergic skin reaction. P280: Wear protective gloves. P302 + P352: IF ONSKIN: Wash with plenty of soap and water. P333 + P313: If skin irritation or rashoccurs: Get medical advice/attention. P363: Wash contaminated clothing beforereuse.Refer to for the Safety Data Sheets and forOrtho contact information.WARNINGMaterials Provided3 sets of VITROS Anti-SARS-CoV-2 IgG Controls 1 and 2 (human matrix with anti-microbial agent, 2 mL)Materials Required but Not ProvidedPipette, sample containers.Control Storage, Preparation and HandlingControl Storage ConditionStability Unopened Refrigerated 2–8 °C (36–46 °F)expiration date Opened Refrigerated 2–8 °C (36–46 °F)≤8 weeks Opened Frozen≤-20 °C (≤-4 °F)≤8 weeks•VITROS Anti-SARS-CoV-2 IgG Controls are supplied ready to use.•VITROS Anti-SARS-CoV-2 IgG Controls are suitable for use until the expiration date on the carton when stored and handled as specified. Do not use beyond the expiration date.•Avoid repeated freeze-thaw cycles.•Thoroughly mix controls by inversion and bring to 15–30 °C (59–86 °F) before use.•Handle controls in stoppered containers to avoid contamination and evaporation. To avoid evaporation, limit the amount of time controls are on the system. Refer to the operating instructions for your system.•Return to 2–8 °C (36–46 °F) as soon as possible after use, or load only sufficient for a single determination.•The expiration date for the controls must be entered onto the system. For further information, refer to the operating instructions for your system.Testing ProcedureLoad each control onto the system by transferring an aliquot into a sample container (taking account of the volume required by the test and the minimum fill volume of the container). Process in the same manner as samples, according to the instructions in the appropriate VITROS Immunodiagnostic Products Reagent Pack and Calibrator instructions for use.Note:Do not use visibly damaged product.For further information on quality control procedures refer to the operating instructions for your system.Not all products and systems are available in all countries.Baseline StatisticsVITROS Anti-SARS-CoV-2 IgG Control 1 should generate Non-reactive (Negative) results.VITROS Anti-SARS-CoV-2 IgG Control 2 should generate Reactive (Positive) results.References1.CLSI. Protection of Laboratory Workers from Occupationally Acquired Infections; Approved Guideline - Fourth Edition.CLSI document M29-A4. Wayne, PA: Clinical and Laboratory Standards Institute; 2014.2.Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification,labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC,and amending Regulation (EC) No 1907/2006.CoV2GINSTRUCTIONS FOR USEMaterials ProvidedGlossary of SymbolsRevision HistoryDate of Revision Version Description of Technical Changes*2020-05-134.0Back Page: updated* The change bars indicate the position of a technical amendment to the text with respect to the previous version of the document.When this Instructions For Use is replaced, sign and date below and retain as specified by local regulations or laboratory policies, as appropriate.SignatureObsolete DateINSTRUCTIONS FOR USECoV2GGlossary of SymbolsCoV2GINSTRUCTIONS FOR USERevision HistoryConditions of supply: all supplies are made subject to the standard terms and conditions of Ortho ClinicalDiagnostics or its distributors. Copies of these are available on request.Ortho-Clinical Diagnostics1500 Boulevard Sébastien Brant B.P. 3033567411 Illkirch CEDEX, FranceOrtho-Clinical Diagnostics Felindre Meadows Pencoed Bridgend CF35 5PZUnited KingdomVITROS is a registered trademark of Ortho Clinical Diagnostics.© Ortho Clinical Diagnostics, 2020。
构件表面裂纹损伤电位检测法
收稿日期:2007-08-02作者简介:张善智(1979 ),男,湖北荆州人,博士研究生,主要从事结构损伤检测等方面的研究;阎云聚(1955 ),男,教授,博士生导师,主要从事结构损伤检测等方面的研究。
构件表面裂纹损伤电位检测法张善智,闫云聚(西北工业大学力学与土木建筑学院,陕西西安 710072)摘要:通过基于铝箔纸和镍覆层的实验,提出了以覆于构件表面被检测区域的覆层作为传感器、通过测量覆层上某些点之间的一组电位差值或一组电阻值来判断构件表面疲劳裂纹长度及其出现位置的方法。
实验结果表明该方法是可行的。
关键词:裂纹损伤检测;电位法;表面覆盖技术中图分类号:TP212 文献标识码:A 文章编号:1000-8829(2008)06-0001-04E lectric Potential D etecti on M ethod for Surface Crack of StructuresZHANG Shan zh ,i YAN Y un j u(S chool ofM echan i cs ,C i v il and Arch i tecture ,Nort hw es t ern Polyt echn i calU n i vers it y ,X i an 710072,Ch i na)Abstrac t :Through experi m ents based on a l u m i n i u m paper and n ickel coati ng ,an approach wh i ch can be used to detec t crack lengthand c rack locati on by m eas ur i ng a se t of e l ectric po tential d ifference o r resistance va l ues bet ween any t wo po i n ts on t he structura l surface ,is propo sed .The result shows t ha t it is feasi b l e t o detect crack da m age on the struc t ura l surface usi ng the proposed techno l ogy and coati ng sensors .K ey word s :c rack da m age de tecti on ;e l ec tric po tential m ethod ;surface coati ng techno l ogy 飞机结构的安全问题一直是人们关注的重点。
英语二作文石雷鹏预测
英语二作文石雷鹏预测Sure, here's a sample English essay for the topic "Shi Leipeng's Predictions for English Writing II":---。
Shi Leipeng's Predictions for English Writing II。
In recent years, the predictions made by Shi Leipengfor the English Writing II section have garneredsignificant attention among students preparing for this examination. His insights offer valuable guidance for those aiming to excel in this component of the English exam.Let's delve into some of the anticipated areas of focus based on his predictions.Firstly, Shi Leipeng emphasized the importance of coherence and cohesion in writing. It's expected that examiners will continue to evaluate candidates based on their ability to present ideas logically and coherently.Therefore, mastering transitional devices and employing cohesive elements such as pronouns and conjunctions will likely enhance the overall structure and coherence of the essay.Secondly, vocabulary enrichment is anticipated to be a key aspect highlighted by Shi Leipeng. While a wide range of vocabulary demonstrates language proficiency, it's equally crucial to use words appropriately and accurately. Candidates are advised to avoid overreliance on memorized phrases and instead focus on incorporating vocabulary naturally within the context of their arguments.Additionally, Shi Leipeng hinted at the significance of critical thinking and analysis in English Writing II. Examiners are likely to assess candidates' ability to critically evaluate prompts, generate insightful ideas, and provide well-supported arguments. Therefore, developing analytical skills and demonstrating a depth of understanding on various topics will be advantageous for candidates seeking higher scores.Furthermore, Shi Leipeng suggested that candidates should pay attention to grammatical accuracy and sentence structures. While creativity in language use is encouraged, errors in grammar and syntax can detract from the overall quality of the essay. Thus, revising and editing meticulously to ensure grammatical correctness and sentence fluency will be essential for achieving success in the examination.Moreover, an awareness of cultural nuances and global issues is deemed important by Shi Leipeng. Incorporating cultural references and discussing contemporary issues in essays can add depth and relevance to the arguments presented. Candidates are encouraged to stay updated on current events and societal trends to effectively engagewith diverse topics in their writing.In conclusion, Shi Leipeng's predictions offer valuable insights into the key areas of focus for English Writing II. By paying attention to coherence, vocabulary, critical thinking, grammar, and cultural awareness, candidates can enhance their writing skills and improve their performancein the examination. Ultimately, diligent preparation and practice based on these predictions can significantly contribute to achieving success in English Writing II.--。
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a r X i v :0805.2093v 2 [h e p -e x ] 13 J u n 2008June 13,2008Re-evaluation of the LHC potential for the measurement of m W Nathalie Besson,Maarten Boonekamp (CEA-Saclay),Esben Klinkby,Sascha Mehlhase,Troels Petersen (NBI)Abstract We present a study of the LHC sensitivity to the W boson mass based on simulation studies.We find that both experimental and phenomenological sources of systematicuncertainties can be strongly constrained with Z measurements:the lineshape,d σZ /d m ,is robustly predicted,and its analysis provides an accurate measurement of the detector resolution and absolute scale,while the differential cross-section analysis,d 2σZ /d y d p T ,absorbs the strong interaction uncertainties.A sensitivity δm W ∼7MeV for each decay channel (W →e ν,W →µν),and for an integrated luminosity of 10fb −1,appears as a reasonable goal.1IntroductionThe Standard Model(SM),now computed at two-loop precision[1,2],is a very predictive framework. Its most precisely measured parametersαQED,Gµ,and m Z,provide constraints on the W boson and top quark masses,which can be confronted with measurement.Injecting the measured value of the W mass and the measured Z boson couplings,a definite prediction is given for the top quark mass[3]. This prediction,together with the discovery of the top quark at a compatible mass[4,5],has been a major achievement in high energy physics.The measured values of the W boson and top quark masses are now more precise than their quantum predictions,and provide non-trivial constraints on the gauge symmetry breaking sector.In the SM, this translates into limits on the Higgs boson mass[6].Beyond the SM,constraints are given on the contributions of other heavy particles,like supersymmetric particles[7].The W mass has been measured at UA2[8],LEP[6],and the Tevatron[9].The recent measure-ment by the CDF Collaboration gives m W=80.413±0.048GeV,yielding a current world average of m W=80.398±0.025GeV[10].In the SM,the resulting Higgs boson mass uncertainty is about50%. Any further improvement in this measurement will translate into more precise indirect predictions. The present paper discusses the LHC prospects for the W mass measurement.The expected W cross-section at the LHC is about20nb[11].In10fb−1of data,a benchmark for one year of in-tegrated luminosity during thefirst years of stable running,around4×107W events will be selected in each exploitable decay channel(W→eν,µν),providing a combined statistical sensitivity of about 1MeV.Previous estimates[12–14]of the systematic uncertainties affecting this measurement how-ever amount toδm W∼20MeV per experiment,and to a combined uncertainty ofδm W∼15MeV. The main sources are the imperfect determination of the experiments absolute energy scale,and the uncertainties in the W boson kinematical distributions(rapidity,transverse momentum),which in turn stem from proton structure function uncertainties and higher orders QCD effects.The purpose of this paper is to re-investigate the possibilities to measure the W mass with the great-est possible precision.As is known from the Tevatron,the uncertainties can be significantly reduced using Z boson measurements;this approach will be employed here,with modifications and improve-ments suggested by the high Z statistics expected.Although our discussion is general,most of our arguments rely on the expected performance of the ATLAS experiment[15].The paper is structured as follows.Section2summarizes the W massfitting procedure,lists the in-gredients needed to describe the W distributions used in thefit,and gives a general description of how these ingredients can be determined.The sources of uncertainty are then discussed in turn,in Sec-tion3(experimental uncertainties),Section4(theoretical uncertainties),and Section5(backgrounds, underlying event,and effects related to the machine operation).Correlations between these effects are discussed in Section6,and the results are given in Section7.Section8concludes the paper.2General discussionThis section discusses our technical set-up,the W and Z event selection,the massfitting procedure, and the problem of controlling all ingredients entering in the definition of thefitted distributions.22.1W and Z production.Event generation and simulationThroughout this paper,W and Z boson samples,and their distributions and acceptances are computed using the PYTHIA general purpose event generator[16].On top of PYTHIA,the treatment of pho-ton radiation in W and Z decays is done via an interface to PHOTOS[17].The size of the expected samples are computed assuming the NLO W and Z cross-sections,as obtained from RESBOS[18]. These choices are not unique,and the simulation of physics processes at the LHC,in particular non-perturbative strong interaction parameters,will obviously need to be adjusted using the forthcoming data.In this analysis,the effects of the corresponding uncertainties are estimated either by changing parameters in these programs,or by distorting the output distributions according to our assumptions. When referring to“fast simulation”,we mean a simplified simulation of the ATLAS detector response using scale factors and Gaussian resolution functions,applied to the generator-level information ob-tained above[19].When referring to“full simulation”,we mean the complete simulation of the ATLAS detector using GEANT4[20].In our discussions below,and in the absence of real physics data, we often treat our fully simulated event samples as data samples,and the fast simulation samples as their Monte-Carlo simulation.The different detector response in fast and full simulation allows to emulate the realistic situation where the imperfect detector simulation is adjusted during data taking.2.2Signal selection andfitting procedureAt hadron colliders,W and Z events can be detected and reconstructed in the eνe,µνµ,ee,andµµfinal states.The hadronic modes suffer prohibitively large background from jet production;τmodes can be detected but theτ-lepton decay produces additional undetected particles in thefinal state,di-luting the information that can be extracted from these modes.In W events,the observables most sensitive to m W are:•The reconstructed lepton transverse momentum,pℓT;•The reconstructed W transverse mass,m W T≡Channel W→lνZ→llFigure2:χ2value as function of the tested value of m W.Each dot represents a comparison between the data and the template distribution obtained for a given m W.The curve is thefitted parabola.The different template distributions are obtained by varying the value of the W boson mass parameter in the event generation.The statistical comparison of the data to the templates can be performed in various ways;throughout this study we will use a simple binnedχ2test.Theχ2quantifying the compatibility of a given template distribution with the data is defined as follows:χ2=∑i (n obs i−n exp i)2•Theoretical inputs:the W rapidity distribution,y W,affects the m W T and pℓT distributions.The trans-verse momentum of the W,p W T,directly affects the pℓT spectrum;its impact is weaker on the m W T spectrum.The y W and p W T distributions depend on the proton structure functions and on higher-order QCD effects.The lepton angular distribution in the W rest frame is of importance for both pℓT and m W T and changes with the W polarization[22].Finally,QED effects(photon radiation in the W decay) shifts the lepton p T downwards.Since the radiated photons are mostly collinear to the charged decay lepton,the impact on electrons and muons is different:the measured muon momentum entirely re-flects the momentum loss by radiation,whereas the electron energy,measured essentially in the EMC, includes most of the radiated energy.•Environmental inputs:these include,among others,backgrounds surviving the W selection,un-derlying event and pile-up effects on reconstructed energies and momenta,random neutron hits in the muon spectrometer(“cavern background”),and the impact of a non-zero beam crossing angle.In all cases,imperfect modelling of these inputs biases the event reconstruction,leading to distorted pℓT and m W T distributions.2.4Propagation of systematic uncertaintiesThe impact of underlying physics mechanisms affecting the W mass determination is estimated by producing template distributions of pℓT and m W T unaware of the effect under consideration,andfitting them to pseudo-data including this effect.The resulting bias(i.e.the difference between the injected andfitted values of m W)gives the corresponding systematic uncertainty.In the simplest case,a physics effect affecting the distributions(for a given value of the W mass)can be summarized by a single parameter.In this case,the induced systematic uncertainty is simply given by:∂m Wδm W=∂m W∂relαi2.5The impact of Z boson measurementsThe LHC will produce a large number of Z events.Their selection is rather straightforward,requir-ing two reconstructed isolated,high-p t leptons(pℓT>20GeV,|ηℓ|<2.5),and low hadronic activity (hadronic recoil smaller than30GeV).For each useful decay mode(Z→ee,µµ)and for∼10fb−1,around3.5×106events should survive selections.This represents a factor10less than the expected W statistics,but the fact that Z events are fully reconstructed largely compensates this deficit.Cross-sections and statistics are summarized in Table1.The precise knowledge of the Z mass and width will allow to determine the lepton energy scale and resolution precisely.Exploiting the energy distribution from the decay leptons will also allow to de-termine the scale’s energy dependence(i.e,the linearity of the detector response),and the energy dependent resolution function.Once this is achieved,the Z transverse momentum will also serve to scale the measured hadronic recoil to the Z;together with the measured lepton transverse momentum, this defines the missing transverse energy.Finally,“tag and probe”methods[23]will allow to deter-mine the lepton reconstruction efficiency.Although most of the QCD mechanisms affecting W distributions carry significant uncertainty[24], they affect W and Z events in a similar way.This is the case for non-perturbative contributions to the W transverse momentum distributions,but also for parton density(PDF)effects:at the LHC,the W and the Z are essentially sensitive to high-Q2sea partons,and a variation of these parameters will affect the W and Z distributions(in particular y W,y Z)in a correlated way.Hence,the measurement of the Z distributions will help to control the W ones.The simulation of QED radiation in W and Z decays was much improved recently[17,25].Still, the measurement of this process(through e.g.Z→ℓℓγ)will allow to confirm the predictions.Other sources of uncertainty(e.g.backgrounds and underlying event)will also be controlled by auxiliary measurements at the LHC.The following sections attempt to quantify the above arguments.3Experimental uncertaintiesThis section assesses the effect of efficiency and resolution in the reconstruction of leptons and missing transverse energy.3.1Lepton scale and resolutionThe Z boson resonance has been measured very precisely at the lepton colliders during the90’s[3]. The Z boson mass and width can be exploited as an absolute reference to determine as precisely as possible the detector energy scale,its linearity and resolution.The basic method is rather simple,and consists in comparing the position and width of the observed mass peak in reconstructed dilepton events with the Z boson parameters.A shift of the observed po-sition of the mass peak,with respect to the nominal Z peak position,is corrected for by scaling the7detector response,hence determining the detector absolute scale;the additional spread of the mass distribution,as compared to the natural Z boson width,is used to estimate the resolution.The high statistics expected at the LHC,however,imposes a number of refinements.First,the scale obtained as above is averaged over the lepton kinematical spectrum,whereas an energy-dependent scale is needed for a correct description of the Jacobian distributions in W events.Secondly,lepton energy resolution effects induce a small but non-negligible shift in the di-lepton invariant mass distri-bution.This shift needs to be subtracted before converting the scale measured from the Z invariant mass distribution into the scale used to describe the Jacobian distributions in W events.The resulting method has been described in detail in Ref.[26],and is summarized below.3.1.1Average detector scaleWefirst illustrate the energy-independent method,providing an average detector ing the PYTHIA event generator[16],we produce a set of template histograms corresponding to generator-level Z lineshapes.The decay leptons are smeared and decalibrated with different energy scale factors αand resolution functionsσ.For definiteness,we consider calorimeter-like resolution functions√parametrized asσ(E)=a×Figure3:Comparison of a fully simulated Z→ee sample(dots)to an initial template example, produced withα=1and a=0.12,and to the bestfit result.3.1.2Linearity:energy dependent scale and resolutionThe above method can be extended as follows.The data and the templates are classified as a function of the lepton energies.This leads to templates and pseudo-data labeled(i,j),corresponding to the event categories where one lepton falls in bin i,and the other in bin j.The scale factorαi j and the resolution parameter a i j are thenfitted in every bin.In case of small non-linearities of the calorimetry response(i.e.αi j,αi,αj very close to1),we can then derive theαi from theαi j,writing infirst order approximation that the mass peak decalibration results from the decay lepton decalibrations:αi j m12=m4i j =σ2iE2j(6)which can again be solved using least squares,yielding theσi.We thus obtain the energy-dependent resolution function,independently of the form used to produce the templates.9Figure4:Left:reconstructed absolute energy scale,as a function of energy(points with error bars). The full line gives the injected function,representing the effect of non simulated passive material in front of the calorimeter.The dashed line is an empirical functionfitted through the points;the dot-dashed line shows the result of an energy-independent analysis,missing the non-linearities.Right: reconstructed energy resolution(points with error bars).The full line is the true resolution function,√of the formσ(E)/E=a/∼800MeV/%,∂relαℓas illustrated in Figure5.In the case of an energy-dependent scale,the uncertainty on m W is obtained by injecting random, energy-dependent decalibrations in the pseudo-data,with a spread corresponding to the result of the analysis of Section3.1.2.With480independent exercises of this type,we obtain a distribution of m f it W as shown on Figure6.The scale-induced W mass uncertainty is given by the spread of this distribu-tion,and isδm W(αℓ)=4MeV.10Figure 5:Left:bias on m W ,m f it W −m true W ,as a function of the relative bias on αℓ,δαℓ=(αf it ℓ−αtrue ℓ)/αtrue ℓ.Right:bias on m W as function of the resolution bias,δσℓ=(σf it ℓ−σtrue ℓ)/σtrue ℓ.Alinear dependence is observed in each case,with ∂m W /∂rel αℓ=800MeV /%and ∂m W /∂rel σℓ=0.8MeV /%.Figure 6:Distribution of m f itW ,for 480exercises with energy-dependent scale parameters randomly drawn within their uncertainties.The true mass is m W =80.33GeV;the systematic uncertainty is ∼4MeV.11The effect of the resolution is studied by varying the resolution parameter in the pseudo-data,fitting to templates withfixed resolution,and collecting the corresponding values of m f it W.This provides the relation between the resolution bias and the resulting bias on m W:∂m WFigure7:Electron(left)and muon(right)ηdistributions at reconstruction level,for W and Z events. This confrontation of measurements is expected to allow to understand the source of any observed non-linearities in terms of magneticfield effects,imperfect alignement,excess of passive material in the detector,etc.It will thus be possible to confront several independent probes of the detector scale;compatibility between these measurements then validates its use for the measurement of m W. This discussion is familiar from the Tevatron m W measurements[9,10].The present analysis,using Z events only,quantifies the precision achievable at the LHC provided all measurements of the scale agree.3.2Lepton reconstruction efficiencyThe observed Jacobian distributions in W events also reflect any p T dependence of the lepton recon-struction efficiency.Any difference between the simulation used to produce the templates and the data will induce a distortion of the spectrum and cause a bias in the massfit.We again take the electron channel as our main example.The ATLAS electron identification largely exploits the shapes of their calorimetric showers[15],which have significant energy dependence. Hence,any selection based on these will have a p T-dependent efficiency which has to be appropri-ately simulated in the templates.Unlike the electrons,no strong p T dependence affects the muon reconstruction efficiency.3.2.1Electron efficiency measurementsElectron reconstruction efficiency can be determined from the data with Z events,using e.g.the so-called“tag and probe”method[23],which we briefly summarize here.Events are selected with one well-identified electron,and an additional high-p T,isolated track.The invariant mass of these two objects is required to be within10GeV from the nominal Z boson mass. Assuming that this selects Z events with enough purity,the identification efficiency is then obtained by computing the fraction of events where the second object is indeed identified as an electron.The efficiency of the isolation criterion is obtained in a similar way.Simulation studies show that the im-pact of backgrounds on the estimation of the efficiency is small compared to the statistical uncertainty.13Figure8:Electron reconstruction efficiency,as determined from fully simulated Z→ee events. For the present study we use about200000fully simulated Z→ee events,from which the efficiency is evaluated.The result is shown in Figure8,together with an empirical function describing main features of the p e T dependence.The following form:ε(p T)=ε0−a exp(−b×p T)(7) correctly describes the efficiency in the p e T range relevant for the analysis.3.2.2Propagation to m W:δm W(ε)The effect of the efficiency uncertainty is estimated as in the previous section.Template distributions are produced at generator level,with varying values of m W,and applying an efficiency factor accord-ing to the bestfit efficiency function obtained above.One hundred independent pseudo-data samples are generated at afixed mass(m W=80.33MeV).Ef-ficiency functions are applied with parameters drawn randomly within their uncertainties,as obtained in the previous section.For each sample of pseudo-data,afit is performed to the W mass.Thefitted mass values are his-togrammed,and the spread of the histogram gives the corresponding systematic uncertainty.With the efficiency determined using2×105Z boson decays,the efficiency-induced systematic W mass uncertainty is found to beδm W=33MeV.Other functional forms than Eq.7yield the same result. The most sensitive parameter in Equation7is b,the slope in the exponential.It is determined to be b=0.068±0.006,corresponding to a precision of9%;in other words,∂m W/∂rel b∼4MeV/%.To emphasize the importance of this effect,the same pseudo-data samples are compared to templates assuming no p T-dependence in the lepton reconstruction efficiency(i.e.f(p T)=constant).While the same spread is observed,the m f it W distribution indicates an average bias of about450MeV.This bias vanishes,tofirst order,when using the p T-dependent efficiency in the templates.14p T cut<m f it W><δm f it W><m f it W><δm f it W> (εre f=1)(εre f=1)(εre f=f(p T))(εre f=f(p T))Figure9:Left:statistical sensitivity toαE missT ,as a function of the accumulated Z statistics.Right:statistical sensitivity toσE missT.difference(m W=m Z).Assuming that the absolute lepton scale and resolution have been measured beforehand(cf.Sec-tion3.1),one can measure the recoil scale(αrec)and resolution(σrec)in fully reconstructed Z events,where no significant E missT is expected,by comparing the measured hadronic energy E rec,recoilingagainst the Z boson,to the reconstructed di-lepton four-momentum,pℓℓT.Specifically,αrec andσrec are extracted from the peak position and spread of the distribution of E rec/pℓℓT.The results can then be used to correct the observed recoil,and hence E missT,in W events.Figure9shows the expected sensitivity toαrec andσrec.With10fb−1,these parameters can be deter-mined with a statistical precision ofδαrec=5×10−5andδσrec=6×10−4.3.3.2Propagation to m W:δm W(αE missT ),δm W(σE missT)The effect on m W is evaluated by systematically varying the recoil scale,producing corresponding pseudo-data samples as in the previous sections,andfitting each sample to perfectly calibrated tem-plates.We obtain the relation between the m W bias and the recoil scale and resolution in the form of a derivative:∂m W∂relσE missT=−25MeV/%as illustrated in Figure10.InjectingδαE missT =5×10−5,we obtain a systematic uncertainty ofδm W(αE missT )=1MeV.Similarly,wefind the contribution from the resolution to beδm W(σE missT)=1.5MeV.These numbers assume that the Z-based calibration can be transported to the W sample without additional uncertainty;this is discussed further below.3.3.3Further discussionThe E missT calibration can be studied in more detail,using real Z events where one reconstructed leptonis artificially removed.In the case of electrons,the removed calorimetric energy should be properly16Figure 10:Left:Bias on m W ,δm W =m f it W −m true W ,as a function of the bias on the recoil scale,δαE miss T.Right:δm W as function of the resolution bias,δσE miss T .A linear dependence is observed in each case,with ∂m W /∂rel αE miss T =−200MeV /%and ∂m W /∂rel σE miss T=−25MeV /%.Figure 11:Left:electron cluster in a Z →ee event.Right:the same calorimeter region,after thecluster has been removed.The energy in each cell belonging to the electron cluster is replaced by a number drawn from a Gaussian with mean and RMS corresponding to detector noise.replaced by the expected noise.For muons,also,the minimum-ionizing energy depositions in the calorimeters need to be removed and replaced by the expected noise as above.The resulting events mimic W events and have a precisely known missing energy,corresponding to the energy of the re-moved lepton,which can be compared to the result of the E miss Treconstruction algorithm.The lepton removal requires that one can identify and remove the electron signal from the struckcalorimeter cells,while leaving a realistic contribution from noise and hadronic background (see Fig-ure 11).Several approaches can be tried,such as replacing the contents of the electron cluster cells by energy measured away of any high-p T object in the event (e.g.at 90◦in azimuth),or by the average expected electronic and hadronic noise.To determine the E miss Tresolution and possibly correct for biases in its measurement,we consider the reconstructed E miss Tof Z →ℓℓevents before and after the removal of one lepton,and compare the 17Figure12:Transverse view of a)W→ℓνand b)Z→ℓℓevents.The combined transverse momentum of the recoil u,which should match that of the boson,is used to estimate the momentum of the undetected neutrino in the W→ℓνdecay.The Z boson line offlight is represented,which defines the ( ,⊥)coordinate system.The size of the dotted ellipses represent the resolution on the reconstructed objects.difference to the transverse momentum of the removed lepton.A non-zero average value of this dif-ference points to a bias in the E missTreconstruction.Rather than projecting this difference on conventional X and Y axes in the transverse plane,it is best to consider the natural frame of the event,with axes parallel( )and perpendicular(⊥)to the Z bo-son transverse momentum.Imperfect calibration of the E missT reconstruction will show up as biasesin these distributions,which can then subsequently be corrected for within statistics.The axes are illustrated in Figure12.This method is tried on a fully simulated sample of Z→ee events,with results illustrated in Fig-ure13.As can be seen in this example,a bias is observed in the E missT reconstruction along the Zline offlight.No bias is observed along the other axes.In this example,the calibration is thus cor-rect on average,but the E missTreconstruction does not respond perfectly to the event-by-event topology.As this discussion illustrates,E missT reconstruction is a very difficult experimental algorithm to control,especially to the level of precision desired here.Therefore,we cannot claim at present that the sensitiv-ity quoted in the previous section will indeed be reached.Instead,lacking the proof that the statisticalenhancement can be fully exploited,we assume an overall uncertainty ofδm W(E missT )=5MeV.Thisnumber is a factor3higher than the purely statistical sensitivity,and a factor three smaller than the sys-tematic uncertainty obtained in the recent CDF measurement[10]based on an integrated luminosity of200pb−1and about8000Z events for calibration of the hadronic recoil.18Figure13:Top:resolution on E missT,projected onto the(X,Y)coordinate system,for unmodified,fullysimulated Z→ee events.Bottom: E missT resolution in the( ,⊥)coordinate system.The absence ofbias along the X and Y axes show that the overall calibration is correct on average,but the observed bias along the -axis,corresponding to the Z line offlight,indicates imperfect calibration of the response to the event-by-event topology.194Theoretical uncertaintiesWe discuss below the uncertainties related to imperfect physics modeling of W production.The correlation of the mass measurement with the W width,the impact offinal state radiation,and biases in the pℓT and m W T distributions induced by p W T and y W distortions are discussed in turn.4.1W boson width:δm W(ΓW)A change in the W widthΓW affects the Jacobian peak,and can cause a bias in the W mass measure-ment.To assert the size of this effect,samples with the same W mass but W widths varying in the range1.7−2.5GeVwere produced and subsequentlyfitted.The relation betweenΓW and m W in the fit is linear,with a slope depending on the distribution used in the massfit.If the W transverse mass is used,wefind:∂m W=1.2MeV/%∂relΓWThe intrinsic width of the W resonanceΓW has been measured to be2.141±0.041GeV,while the SM prediction is2.0910±0.0015GeV[28].It should be taken into account that the LHC data can be expected to improve the precision on the W width as well as on m W.Earlier measurements of ΓW[29,30]are affected by the same systematic uncertainties as those discussed in this paper.Hence, anticipating on our results,we assume that an improvement by a factorfive should be achievable, respectively leavingδm W(ΓW)=1.3and0.5MeV for the m W T and pℓTfits.4.2QEDfinal state radiation:δm W(QED)Final state radiation causes significant distortions of the naive,lowest order p T spectrum of the W decay leptons.We estimate the stability of the theoretical calculation below,using the PHOTOS pro-gram[17]as a benchmark.The numerical importance offinal state radiation is illustrated in Figure14,which displays the dis-tribution of the measured lepton energy fraction(relative to their energy in the absence of FSR).For electrons,measured via calorimetric energy clusters,most of the(collinearly radiated)photon energy is collected in the cluster.The momentum of muons tracks,on the contrary,is measured indepen-dently of any photon radiation.The average values of the distributions lie at about99%of the original value,meaning that ignoring the effect entirely would cause a bias on the W mass of about800MeV. The theoretical stability of the calculation is thus of critical importance.In recent versions of PHOTOS,it is possible to switch between several theoretical assumptions.In par-ticular,W and Z boson decays can be simulated with photon emission up to O(α),O(α2),O(α4),or with photon emission exponentiation[31].To study the model differences,we have generated about 106events for each setting,and for each production and decay channel(W→ℓν,Z→ℓℓ,forℓ=e,µ).The average values of the energy fractions discussed above are shown in Figure15,for successive theoretical refinements.The different average values for electrons and muons reflect the different20。