拉贝洛尔治疗重度妊娠期高血压临床效果及安全性评价

拉贝洛尔治疗重度妊娠期高血压临床效果及安全性评价
陈冰;刘佳;李春东;张倩
【期刊名称】《河北医学》
【年(卷),期】2015(000)011
【摘要】Objective:To investigate the safety and clinical effects of labetalol in treatment of severe gestational hypertension , and to elevate the quality of childbirth .Method:A total of 50 patients were select-ed and randomly divided into observation group and control group , with 25 patients in each group .All the patients were given with conventional therapies , but the control group was given with nifedipine controlled-release tablets additionally , while the observation group given with labetalol additionally , intravenously dripped first, and then orally taken , and the blood pressures and 24h urine protein content of the patient ,Apgar scores at 1min and
5min after childbirth of the newborn , and childbirth outcomes of the two groups were observed.Result:Before the treatment, the two groups had similar SBP , DBP and 24h urine protein content, and the differences were statistically insignificant (P>0.05); at 1 week after the treatment, both groups had significantly decreased SBP , DBP and 24h urine protein content , and the differences were statis-tically significant ( P<0.05);but the observation group had significantly greater decreasing extents than the control group, and the differences were statistically significant
(P<0.05).The newborns of the observation group had higher Apgar scores
at 1min and 5min after childbirth than the control group , and the differences were statistically significant (P<0.05).The patients of the observation group had better childbirth outcomes than the control group , and the difference was statistically significant
( P<0.05) .Conclusion:Labetalol can effectively control severe gestational hypertension , decrease 24h urine protein content , and significantly im-prove childbirth outcome , has significant clinical therapeutic effects , and consequently is worthy of clinical application .%目的：探讨拉贝洛尔治疗重度妊娠期高血压临床效果及安全性，提高分娩质量。

方法：选择50例患者随机分为观察组和对照组各25例，均给予常规治疗，对照组加用硝苯地平控释片，观察组加用拉贝洛尔，先静脉滴注，然后改为口服，观察组两组患者血压、24h尿蛋白
含量、新生儿出生后1min及5min的Apgar评分、分娩结局。

结果：治疗前，
两组患者SBP、DBP 及24h尿蛋白含量相似，差异无统计学意义（P＞0．05）；治疗1周后，两组SBP、DBP及24h尿蛋白含量较治疗前均明显下降，差异有统计学意义（ P＜0．05），但观察组SBP、DBP 及24h尿蛋白含量下降幅度明显
大于对照组，差异有统计学意义（ P＜0．05）。

观察组新生儿出生后1min及
5min的Apgar评分均高于对照组，差异有统计学意义（ P＜0．05），观察组患者分娩结局明显优于对照组，差异有统计学意义（ P＜0．05）。

结论：拉贝洛尔能有效控制重度妊娠期高血压、降低24h尿蛋白含量，临床疗效显著，显著改善
母婴结局，值得临床推广应用。

【总页数】4页(P1777-1779,1780)
【作者】陈冰;刘佳;李春东;张倩
【作者单位】解放军空军总医院妇产科，北京100142;解放军空军总医院妇产科，北京100142;解放军空军总医院妇产科，北京100142;广州医科大学附属第三医
院生殖医学中心，广东广州 510150
【正文语种】中文
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