低分子右旋糖酐联用速尿持续静滴治疗小儿肾病综合征水肿的效果

低分子右旋糖酐联用速尿持续静滴治疗小儿肾病综合征水肿的
效果
龚敏;叶鑫;诸葛小寅;吴蔚
【期刊名称】《中国医药导报》
【年(卷),期】2014(000)028
【摘要】目的：探讨低分子右旋糖酐联合速尿持续静滴治疗小儿肾病综合征水肿
的临床效果。

方法收集2013年1月~2014年1月衢州市人民医院收治的肾病综
合征水肿患儿52例，随机将其分为观察组与对照组，每组各26例，两组均予以
常规治疗，对照组应用速尿持续静滴，观察组则予以低分子右旋糖酐联合速尿持续静滴，比较两组的临床疗效。

结果观察组的治疗总有效率为100.0%，显著高于对照组(80.8%)，差异有统计学意义(P<0.05)；水肿开始消退时间、血清白蛋白升高时间、多尿时间依次为(15.9±4.2)h、(7.8±1.1)d、(3.5±1.3)h，均较对照组[(28.4±12.3)h、(12.3±1.4)d、(14.3±2.9)h]显著缩短，差异均有统计学意义
(P<0.05)；治疗后两组的24 h尿蛋白及血清胆固醇均较治疗前显著降低，但观察组显著低于对照组，差异均有统计学意义(P<0.05)；两组治疗后血清白蛋白水平
均明显升高，但观察组显著高于对照组，差异有统计学意义(P<0.05)；观察组停
药后水肿复发率为7.7%，显著低于对照组(42.3%)，差异有统计学意义(P<0.05)。

结论低分子右旋糖酐联合用速尿持续静滴治疗小儿肾病综合征水肿效果显著，不良反应少，值得临床推广应用。

%Objective To investigate the clinical efficacy of low molecule dextran combined with furosemide continuous infusion for the treatment of children with nephrotic syndrome. Methods 52 cases of children with nephrotic syndrome from January 2013 and January 2014 in
the People's Hospital of Quzhou City in Zhejiang Province were collected. The children were divided into observation group and control group randomly, with 26 cases in each group. The two groups were received routine treatment, and the control group were given urosemide continuous infusion, the observation group were given low molecule dextran combined with furosemide continuous infusion. The clinical efficacy of the two groups were compared. Results The total effective rate of observation group was 100.0%, significantly higher than that in the control group (80.8%), the difference was statistically significant (P< 0.05); the time of swelling began to subside, ele-vated serum albumin, and polyuria of observation group were (15.9±4.2) h, (7.8±1.1) d, (3.5±1.3) h respectively, which were significantly shorter than those of the control group [(28.4±12.3) h, (12.3±1.4) d, (14.3±2.9) h], the differences were statistically significant (P< 0.05). After treatment, the 24 h urine protein and serum cholesterol in the two groups were significantly reduced compared with before treatment, and the observation group were lower than those of the con-trol group, the differences were statistically significant (P<0.05); the serum albumin levels of the two groups were sig-nificantly elevated, but the observation group was significantly higher than the control group, the difference was statisti-cally significant (P< 0.05). After discontinuation, the edema relapse of the observation group was 7.7%, significantly lower than that in the control group (42.3%), the difference was statistically significant (P<0.05). Conclusion The low molecule dextran combined with furosemide continuous infusion for the
treatment of children with nephrotic syndrome has a significant effect and fewer adverse reactions, it is worthy of clinical application.
【总页数】4页(P55-57,61)
【作者】龚敏;叶鑫;诸葛小寅;吴蔚
【作者单位】浙江省衢州市人民医院儿科，浙江衢州 324000;浙江省衢州市人民医院药剂科，浙江衢州 324000;浙江省衢州市人民医院儿科，浙江衢州 324000;浙江大学医学院附属儿童医院内分泌科，浙江杭州 310003
【正文语种】中文
【中图分类】R692.05
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