Clenbuterol (hydrochloride)_拟交感神经β2-肾上腺素受体激动剂_21898-19-1_Apexbio
合集下载
- 1、下载文档前请自行甄别文档内容的完整性，平台不提供额外的编辑、内容补充、找答案等附加服务。
- 2、"仅部分预览"的文档,不可在线预览部分如存在完整性等问题,可反馈申请退款(可完整预览的文档不适用该条件!)。
- 3、如文档侵犯您的权益，请联系客服反馈,我们会尽快为您处理(人工客服工作时间：9:00-18:30)。
参考文献: [1] Re G, Badino P, Girardi C, Di Carlo F. Effects of a beta 2-agonist (clenbuterol) on cultured human (CG-5) breast cancer cells. Pharmacol Res. 1992 Dec;26(4):377-84. [2] Carter WJ, Dang AQ, Faas FH, Lynch ME. Effects of clenbuterol on skeletal muscle mass, body composition, and recovery from surgical stress in senescent rats. Metabolism. 1991 Aug;40(8):855-60. [3] Brusasco V, Crimi E, Mangini S, Vibelli C. A clinical trial of oral clenbuterol (NAB 365) in chronic airways obstruction. Curr Med Res Opin. 1980;6(7):449-55.
Store at -20°C For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
GPCR/G protein
信号通路:
Adrenergic Receptor
产品描述:
Clenbuterol is a sympathomimetic β2-adrenoceptor agonist. β2-adrenoceptor agonists, mainห้องสมุดไป่ตู้y long-acting β2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.
C12H18Cl2N2O • HCl
NAB 365,Ventipulmin
4-amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]-benzen emethanol, monohydrochloride ClC1=CC(C(O)CNC(C)(C)C)=CC(Cl)=C1N.Cl >13.2mg/mL in DMSO
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
ApexBio Technology
产品说明书
化学性质
产品名: Clenbuterol (hydrochloride) 修订日期: 6/30/2016
产品名: Cas No.: 分子量: 分子式: 别名: 化学名:
SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
Clenbuterol (hydrochloride)
21898-19-1 313.7
In vitro: A hormone dependent human breast cancer cell line was treated with different concentrations of clenbuterol. It was found that clenbuterol could stimulate cell proliferation at low concentrations, but the effect was less marked and significant compared with oestradiol. Probably clenbuterol elicited cell proliferation via a different mechanism, because it did not affect the cellular oestrogen receptor concentration [1]. In vivo: Clenbuterol was administered to Fischer-344 rats, at a dose of 1.5 mg/kg/24 h for 3 weeks. The weights of five hindlimb muscles and carcass protein and fat content were determined. Results showed that clenbuterol treatment could increase the weight of skeletal muscles of all animals. Similarly, clenbuterol increased carcass protein conten, leading to the reduced carcass fat content [2]. Clinical trial: Clenbuterol was compared with terbutaline during a 5-week single-blind crossover study in patients with chronic airways obstruction. Both clenbuterol and terbutaline could significantly improve baseline FEV1 and the bronchodilator effects were similar, suggesting that clenbuterol was a good alternative drug for treatment of chronic airways obstruction [3].
Store at -20°C For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months. Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
生物活性
靶点 :
GPCR/G protein
信号通路:
Adrenergic Receptor
产品描述:
Clenbuterol is a sympathomimetic β2-adrenoceptor agonist. β2-adrenoceptor agonists, mainห้องสมุดไป่ตู้y long-acting β2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease.
C12H18Cl2N2O • HCl
NAB 365,Ventipulmin
4-amino-3,5-dichloro-α-[[(1,1-dimethylethyl)amino]methyl]-benzen emethanol, monohydrochloride ClC1=CC(C(O)CNC(C)(C)C)=CC(Cl)=C1N.Cl >13.2mg/mL in DMSO
特别声明
产品仅用于研究，
不针对患者销售，望谅解。
每个产品具体的储存和使用信息显示在产品说明书中。ApexBio 产品在推荐的条件下是稳定 的。产品会根据不同的推荐温度进行运输。许多产品短期运输是稳定的，运输温度不同于长 期储存的温度。我们确保我们的产品是在保持试剂质量的条件下运输的。收到产品后，按照 产品说明书上的要求进行储存。
ApexBio Technology
产品说明书
化学性质
产品名: Clenbuterol (hydrochloride) 修订日期: 6/30/2016
产品名: Cas No.: 分子量: 分子式: 别名: 化学名:
SMILES: 溶解性: 储存条件: 一般建议:
运输条件:
Clenbuterol (hydrochloride)
21898-19-1 313.7
In vitro: A hormone dependent human breast cancer cell line was treated with different concentrations of clenbuterol. It was found that clenbuterol could stimulate cell proliferation at low concentrations, but the effect was less marked and significant compared with oestradiol. Probably clenbuterol elicited cell proliferation via a different mechanism, because it did not affect the cellular oestrogen receptor concentration [1]. In vivo: Clenbuterol was administered to Fischer-344 rats, at a dose of 1.5 mg/kg/24 h for 3 weeks. The weights of five hindlimb muscles and carcass protein and fat content were determined. Results showed that clenbuterol treatment could increase the weight of skeletal muscles of all animals. Similarly, clenbuterol increased carcass protein conten, leading to the reduced carcass fat content [2]. Clinical trial: Clenbuterol was compared with terbutaline during a 5-week single-blind crossover study in patients with chronic airways obstruction. Both clenbuterol and terbutaline could significantly improve baseline FEV1 and the bronchodilator effects were similar, suggesting that clenbuterol was a good alternative drug for treatment of chronic airways obstruction [3].