卵圆孔未闭,无害抑或有害？一项前瞻性人群研究的证据

卵圆孔未闭,无害抑或有害？一项前瞻性人群研究的证据Meissner; I; Khandheria; B.; K; Heit; J.; A
【期刊名称】《《世界核心医学期刊文摘：心脏病学分册》》
【年(卷),期】2006(002)005
【摘要】OBJECTIVES:We sought to determine the association between patent foramen ovale(PFO), atrial septal aneurysm(ASA), and stroke prospectively in a unselected population sample. BACKGROUND: The disputed relationship between PFO and stroke reflects methodologic weaknesses in studies using invalid controls, unblinded transesophageal echocardiography examinations, and data that are unadjusted for age or comorbidity. METHODS: The use of transesophageal echocardiography to identify PFO was performed by a single echocardiographer using standardized definitions in 585 randomly sampled, Olmsted
County(Minnesota) subjects age 45 years or older participating in the Stroke Prevention: Assessment of Risk in a Community(SPARC) study. RESULTS: A PFO was identified in 140(24.3% ) subjects and ASA in 11(1.9% ) subjects. Of the 140 subjects with PFO, 6(4.3% ) had an ASA; of the 437 subjects without PFO, 5 had an ASA(1.1% , two-sided Fisher exact test,
p=0.028). During a median follow-up of 5.1 years, cerebrovascular
events(cerebrovascular disease-related death, ischemic stroke, transient ischemic attack) occurred in 41 subjects. After adjustment for age and comorbidity, PFO was not a significant independent predictor of
stroke(hazard ratio 1.46, 95% confidence interval 0.74 to 2.88, p=0.28). The risk of a cerebrovascular event among subjects with ASA was nearly four times higher than that in those without ASA(hazard ratio 3.72, 95% confidence interval 0.88 to 15.71, p=0.074). CONCLUSIONS: These prospective population-based data suggest that, after correction for age and comorbidity, PFO is not an independent risk factor for future cerebrovascular events in the general population. A larger study is required to test the putative stroke risk associated with ASA.
【总页数】2页(P52-53)
【作者】Meissner; I; Khandheria; B.; K; Heit; J.; A
【作者单位】Department; of; Neurology; MayoClinic; 200; First; Street; SW; Rochester; MN; 55905; United; States; 不详
【正文语种】中文
【中图分类】R743.33
【相关文献】
1.卵圆孔未闭封堵与药物比较预防卵圆孔未闭相关隐源性卒中复发的有效性和安全性的Meta分析 [J], 马莉花;王满侠;李秀丽;胡浩
2.卵圆孔未闭封堵治疗隐源性卒中合并卵圆孔未闭疗效的Meta分析 [J], 马玉梅;邓斌;张新燕;王满侠
3.卵圆孔未闭对偏头痛的发病以及经导管封堵卵圆孔未闭(PFO)治疗对偏头痛的影响研究 [J], 张莉
4.卵圆孔未闭封堵术对伴卵圆孔未闭的偏头痛患者的疗效 [J], 付强;赵性泉;曹京波;王拥军;王伊龙;刘改芬;白亚秋;王蓬莲
5.卵圆孔未闭封堵术与药物治疗在中青年隐源性脑梗死伴卵圆孔未闭患者二级预防中应用效果的对比研究 [J], 张广绒; 邹兴菊; 刘道申; 刘之荣
因版权原因，仅展示原文概要，查看原文内容请购买。