联合检测血清25羟基维生素D及肿瘤标志物在结直肠癌诊断中的应用

联合检测血清25羟基维生素D及肿瘤标志物在结直肠癌诊
断中的应用
杨晓云;刘蕊
【期刊名称】《中国中西医结合外科杂志》
【年(卷),期】2016(022)005
【摘要】Objective To investigate the value of combined detection of serum 25(OH)D and tumor mark⁃ers in the diagnosis of colorectal cancer (CRC). Methods Serum levels of 25(OH)D, CEA, and CA19-9 were detected in 150 healthy controls and 150 cases of CRC patients. Clinical data and laboratory indexes of recruit⁃ed subjects and pathological data of CRC patients were collected. Results Serum levels of 25(OH)D in pa⁃tients with CRC (33.17 ± 15.75 nmmol/L) was lower than that in healthy controls (41.18 ± 11.59 nmmol/L),P<0.01. CEA and CA19-9 in patients with CRC [3.67(2.14,7.20) ng/mL、8.10(3.10,18.90) U/mL] were higher than those in healthy control [2.26(1.75,3.09) ng/mL、4.82(2.90,7.35) U/mL],P<0.01. Serum 25 (OH) D and CEA in patients with CRC have poor consistency (Kappa=0.174, P<0.05). Serum CEA levels of CRC patients with non-ulcer, high and middle cell differentiation, clinical stage ofⅠ~Ⅱ period and without lymph node metasta⁃sis, were significantly lower than that of CRC patients with ulcer, poorly cell differentiation, the clinical stage ofⅢ~Ⅳ period and lymph node metastasis(P<0.05), but serum 25(OH)D levels in all groups showed no statisti⁃cal difference (P>0.05). Conclusion Combined
detection of 25(OH)D, CEA and CA19-9 may has clinical application value for early diagnosis, recurrence, metastasis and prognosis of CRC.%目的：探讨联合检测血清25羟基维生素D[25(OH)D]及肿瘤标志物在结直肠癌（CRC）诊断中的应用价值。

方法：检测150例正常对照者及150例CRC患者血清
25(OH)D、CEA、CA19-9等指标；收集CRC患者肿瘤临床病理特征资料，进行统计分析。

结果：CRC患者血清25(OH)D水平[（33.17±15.75）nmmol/L]低于正常对照者[（41.18±11.59）nmmol/L]，P＜0.01；CEA及CA19-9水平[分别为3.67(2.14,7.20) ng/mL、8.10(3.10,18.90) U/mL]，高于正常对照者[分别为2.26(1.75,3.09) ng/mL、4.82(2.90,7.35) U/mL]，P＜0.01；CRC患者血清
25(OH)D及CEA水平一致性较差，（Kappa=0.174，P＜0.05）；肿瘤大体类型为非溃疡型、细胞为高中分化、临床分期为Ⅰ~Ⅱ期及无淋巴结转移的CRC患者血清CEA水平均低于大体类型为溃疡型、肿瘤细胞为低分化、临床分期为Ⅲ-Ⅳ期及发生淋巴结转移者（P＜0.05)，但血清25(OH)D水平在各组间的比较均未见统计学差异（P＞0.05)。

结论：联合检测患者血清25(OH)D与肿瘤标志物浓度，对早期诊断CRC及评估病情具有临床应用意义。

【总页数】5页(P445-449)
【作者】杨晓云;刘蕊
【作者单位】天津市人民医院检验科天津 300191;天津市人民医院检验科天津300191
【正文语种】中文
【中图分类】R735.3
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