Daidzein_486-66-8_DataSheet_MedChemExpress

Product Name:

Daidzein CAS No.:

486-66-8Cat. No.:

HY-N0019Product Data Sheet

MWt:

254.24Formula:

C15H10O4Purity :>98%

Solubility:

DMSO 50 mg/mL; Water <1 mg/mL

Mechanisms:

Biological Activity:

Daidzein is an inactive analogue of genistein, a tyrosine kinase inhibitor and an estrogen receptor

Pathways:Others; Target:Estrogen Receptor/ERR g g ,y g p

activator.

Target: Tyrosine Kinase; Estrogen Receptor Daidzein, one of the major soy phytoestrogens, had biphasic effects on osteogenesis and

adipogenesis. Daidzein stimulated osteogenesis (ALP activity and nodule formation) and decreased adipogenesis (the number of adipocytes) at concentrations below 20 microM, whereas it inhibited osteogenesis and stimulated adipogenesis at concentrations higher than 30 microM. In addition to ERs, daidzein transactivated not only peroxisome proliferator-activate receptor gamma

(PPARgamma), but also PPARalpha and PPARdelta at micromolar concentrations [1].D id i h b th t i d ti t i ff t E i t i ll d i i l References:

[1]. Dang, Z. and C.W. Lwik, The Balance Between Concurrent Activation of ERs and PPARs Determines Daidzein ‐Induced Osteogenesis and Adipogenesis. Journal of Bone and Mineral Research 200419(5):p 853861Daidzein has both estrogenic and anti-estrogenic effects. Experiments in cells and in animals showed that even low concentration stimulates breast tumor growth in in vitro and in viv... Research, 2004. 19(5): p. 853-861.

[2]. de Lemos, M.L., Effects of soy phytoestrogens genistein and daidzein on breast cancer growth.

Annals of Pharmacotherapy, 2001. 35(9): p. 1118-1121.Caution: Not fully tested. For research purposes only

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