一种软骨修复用水凝胶的制备及其用于软骨损伤修复的研究

一种软骨修复用水凝胶的制备及其用于软
骨损伤修复的研究
Soft cartilage repair hydrogels are prepared by introducing bioactive substances into a polymeric network, which provide an ideal environment for cartilage regeneration and promote the healing process of injured cartilage. The fabrication method involves the incorporation of biocompatible polymers with unique properties into a hydrogel matrix, allowing for customizable mechanical strength, porosity, and degradation rate. In addition, bioactive molecules such as growth factors or stem cells can be incorporated to enhance the regenerative properties of the hydrogel.
软骨修复用水凝胶是通过将生物活性物质引入聚合物网络中制备而成的，它为软骨再生提供了理想的环境，并促进受损软骨的愈合过程。

制备方法涉及将具有独特性能的生物相容性聚合物与一种水凝胶基质结合，从而实现可定制的机械强度、多孔性和降解速率。

还可以引入生长因子或干细胞等生物活性分子，以增强水凝胶的再生能力。

The choice of polymers plays a crucial role in determining the properties and performance of the hydrogel. Natural polymers such as chitosan, hyaluronic acid, or collagen can provide a scaffold-like structure that mimics the extracellular matrix (ECM) found in native cartilage tissue. Synthetic polymers like polyethylene glycol (PEG) or polyethylene oxide (PEO) offer controllable characteristics such as mechanical strength and degradation rate. Hybrid hydrogels that combine natural and synthetic polymers can achieve a balance between bioactivity and mechanical stability.
聚合物的选择在决定水凝胶的性质和性能方面起着至关重要的作用。

天然聚合物如壳聚糖、透明质酸或胶原蛋白可以提供一种类似于天
然软骨组织中的细胞外基质（ECM）的支架结构。

而诸如聚乙二醇（PEG）或聚乙二氧化物（PEO）之类的合成聚合物则具有可控性能，如机械强度和降解速率。

将天然聚合物与合成聚合物相结合的混合
水凝胶可以在生物活性和机械稳定性之间取得平衡。

The incorporation of bioactive molecules within the
hydrogel can further enhance its regenerative capacity. Growth factors, such as transforming growth factor-beta
(TGF-β) or insulin-like growth factor-1 (IGF-1), can stimulate cellular proliferation and differentiation. Stem cells, either derived from the patient's own body or from a donor source, have the ability to differentiate into chondrocytes and aid in cartilage repair. By incorporating these molecules into the hydrogel scaffold, it becomes possible to provide localized and sustained release of bioactive factors at the injury site, promoting tissue regeneration.
在水凝胶中引入生物活性分子可以进一步增强其再生能力。

生长因子，如转化生长因子-beta（TGF-β）或类胰岛素生长因子-1（IGF-1），能够刺激细胞增殖和分化。

干细胞无论是来源于患者自身还是供体，都具有向软骨细胞分化的能力，并协助软骨修复。

通过将这些分子引入水凝胶支架中，可以在受伤部位提供局部和持久的生物活性因子释放，促进组织再生。

In summary, the preparation of soft cartilage repair hydrogels involves incorporating bioactive substances into a polymer network to create an environment conducive to regenerative processes. The choice of polymers and the incorporation of bioactive molecules can be tailored to
achieve desired mechanical properties and promote cartilage regeneration. By combining these strategies, soft cartilage repair hydrogels hold promise in the field of tissue engineering for the treatment of cartilage injuries.
制备软骨修复用水凝胶涉及将生物活性物质纳入聚合物网络中，以创造有利于再生过程的环境。

聚合物的选择和生物活性分子的引入可以量身定制以实现理想的机械性能并促进软骨再生。

通过结合这些策略，软骨修复用水凝胶在组织工程领域治疗软骨损伤方面具有巨大潜力。