六味安消胶囊联合奥美拉唑治疗功能性消化不良的临床效果观察

六味安消胶囊联合奥美拉唑治疗功能性消化不良的临床效果观
察
潘铁生;张军;谈丰平
【期刊名称】《中国生化药物杂志》
【年(卷),期】2017(000)004
【摘要】目的观察六味安消胶囊联合奥美拉唑治疗功能性消化不良的临床效果.方法纳入2014年6月～2016年6月我院收治的功能性消化不良患者111 例,按随机数字表法分为观察组55 例和对照组56 例.对照组给予奥美拉唑治疗,观察组患者在对照组基础上加用六味安消胶囊联合治疗.记录并分析2 组患者治疗前后胃动素和胃电图主频变化情况、胃窦收缩幅度、症状积分、临床疗效和治疗过程中不良反应情况.结果①观察组治疗后胃动素和胃电图主频分别为(491.59 ±25.01)mg/L、(2.92 ±0.34)cpm,均显著高于对照组(416.73 ±23.14)mg/L、(1.89 ±0.23)cpm,且差异均具有统计学意义( P< 0.05).②观察组治疗后胃窦收缩幅度为
(1.60±0.09)％,高于对照组(1.34±0.07)％,且差异具有统计学意义( P< 0.05).③观察组治疗后症状积分为(10.56±1.74)分,低于对照组(14.68±2.13)分,且差异具有统计学意义( P< 0.05).④观察组治疗后总有效率为90.91％,显著高于对照组73.21％,且差异具有统计学意义( P< 0.05).⑤观察组治疗过程中总不良反应比例为7.27％,低于对照组10.71％,但差异无统计学意义.结论六味安消胶囊联合奥美拉唑可有效治疗功能性消化不良,缓解患者相关症状,治疗效果优于单独使用奥美拉
唑.%Objective To observe the clinical efficacy of Liuweianxiao capsule combined with omeprazole to the treatment of functional
dyspepsia.Methods 111 patients with functional dyspepsia from June 2014
to June 2016 were randomly divided into observation group 55 cases and control group 56 cases.The control group received Omeprazole treatment,observation group were given Liuweianxiao capsule combined with omeprazole.Recorded and analyzed motilin levels,EGG frequency changes,antral contraction amplitude,symptom score,the clinical efficacy and adverse reactions during t reatment.Results ①After treatment,Motilin and EGG frequency levels were(491.59±25.01)mg/L、
(2.92±0.34)cpm,better than the control group(416.73±23.14)mg/L、(1.89±0.23)cpm,and the differences were statistically significant(P<0.05).② After treatment,antral contraction amplitude levels
were(1.60±0.09)％,better than the control group(1.34±0.07)％,and the differences were statistically significant(P<0.05).③After
treatment,symptom score levels were(10.56±1.74)point,better than the control group(14.68±2.13)point,and th e differences were statistically significant(P<0.05).④The total effective rate of observation group after treatment was 90.91％,significantly higher than the control group
73.21％,and the differences were statistically significant(P<0.05).⑤ The adverse reactions of observation group during treatment was 7.27％,and compared to the control group 10.71％,the difference was not significant.Conclusion Liuweianxiao capsule combined with Omeprazole can effectively remission related symptoms,and it is a safe and effective treatment.
【总页数】3页(P161-163)
【作者】潘铁生;张军;谈丰平
【作者单位】安吉县第二人民医院内科,浙江安吉 313307;湖州市中心医院消化内科,浙江湖州 313000;安吉县人民医院消化内科,浙江湖州 313000
【正文语种】中文
【中图分类】R259.7
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