Bosentan hydrate_157212-55-0_MSDS_MedChemExpress

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邓氏蜡水说明书

邓氏蜡水说明书
金属除蜡水适用于不锈钢，铁，铝、锌合金等各类金属工件的除腊。

采用独有的纳米溶蜡剂.渗透剂.助溶剂.防腐剂等优质表面活剂经科学配制而成。

具有除蜡快，润湿渗透能力强，持效时间长，防蚀效果优异；使抛光表面光亮无斑及水洗性好等特点。

是代替三氯乙烯的最佳新产品。

物化指标 :
外观：无色透明液体；
比重：1.01±0.02;
PH值: 8.5--9.5(1%水溶液)
沸点：≥100℃
使用方式:
1．超声波清洗：配比浓度：20--50毫升/升
清洗温度：65--80℃
清洗时间：1 --5分钟 2．浸泡清洗：配比浓度：30--70毫升/升
清洗温度：75--85℃
清洗时间：3 --10分钟操作规程:
1．清洗液的配制：将清水注入干净的槽中，加热至75℃左右，在搅拌下按比例缓缓加入本品，再升至清洗所需温度即可使用。

2．清洗液的维护：清洗液在使用过程中浓度会渐渐降低，除腊速度也随之减慢，应定期添加本品添加量一般由分析结果来定。

当清洗液中溶腊过多时，应及时换槽以保证除腊效果。

包装规格: 25KG/塑胶桶。

十二烷基硫酸钠规格

十二烷基硫酸钠规格英文回答：Sodium Dodecyl Sulfate Specifications.Sodium dodecyl sulfate (SDS), also known as sodium lauryl sulfate (SLS), is an anionic surfactant commonly used in a wide range of applications, including detergents, personal care products, and industrial processes. SDS is characterized by its ability to form micelles in aqueous solutions, which gives it excellent detergency and emulsifying properties.Physical and Chemical Properties.Molecular formula: CH3(CH2)11OSO3Na.Molecular weight: 288.38 g/mol.Appearance: White or slightly yellowish powder.Odor: Characteristic odor.pH (1% solution): 7.0-9.0。

Melting point: 205-210°C.Boiling point: Decomposes above 300°C.Solubility: Soluble in water, insoluble in organic solvents.Technical Specifications.Active content: 95.0% min.Sodium chloride (NaCl): 2.0% max.Sulfuric acid (H2SO4): 0.2% max.Heavy metals (as Pb): 10 ppm max.Color (Gardner): 5 max.Odor: Slightly characteristic.Applications.Detergents and cleaning agents.Personal care products (e.g., shampoos, soaps, toothpastes)。

资生堂新品液相色谱柱思普乐介绍资料2_4

反相色谱柱S P O L A RSPOLAR C18　专为中国用户开发的普适型色谱柱～SPOLAR…Stable and Popular稳定而普适的色谱柱～思普乐C18柱使用高纯度硅胶为基材，在导入碳十八基团后采用资生堂公司独有的封端技术对色谱填料进行处理，有效地降低了色谱填料中残存硅醇基的2次影响。

思普乐C18柱通过合理优化制造步骤和生产工艺，有效的降低了生产成本，让更多的中国用户可以亲身体验资生堂色谱柱的高品质。

思普乐色谱柱卓越的耐酸能力、广泛的适用性和尖锐对称的峰形必将使您爱不释手。

表面极性具有良好的耐酸性，可在酸性条件下安定使用。

C18色谱柱在酸性条件下使用时,Si-O键易断裂导致C18流失,从而降低色谱柱的使用寿命。

我们参考考察卡赛帕克ACR耐酸性实验时的方法，特别选用苛刻的酸性流动相对思普乐C18进行考察,思普乐C18表现出了卓越的耐酸性。

耐酸性实验　物性值/参数图125300 2.82～10L119C18(碳十八基)　极性化合物以尖锐峰形快速溶出思普乐C18与卡赛帕克C18 MG相比具有略低的表面极性和疏水性，与卡赛帕克C18 UG120的保留能力相近。

对极性化合物的保留时间更短，峰形更加尖锐。

色谱柱：SPOLAR C18 5μm4.6 mm i.d.×150mm流动相：甲醇/三氟乙酸/水=10/1/89 （pH=1.0-1.2）流速：1.0 mL/min温度：60°C检测：UV 254 nm进样量：7μL样品：尿嘧啶苯甲醇（于25%甲醇溶液）※进行20小时的重复操作，苯甲醇的保留因子的维持率(%)通液时间（h）k维持率%①②③④⑤⑥⑦⑧⑨⑩０10203040[min]CAPCELL PAK MGCAPCELL PAK UG120SPOLAR色谱柱：5μm4.6 mm i.d.×150mm流动相：50% 甲醇流速：1.0 mL/min温度：40°C检测：UV 254 nm样品：十种标准样品（极性到非极性化合物）①尿嘧啶②咖啡因③苯酚④2-乙基吡啶⑤苯甲酸甲酯⑥苯⑦N,N’-二甲基苯胺⑧甲苯⑨1-苯基-2,4-戊二酮⑩萘达到10万/m的理论塔板数色谱柱：SPOLAR C18 5μm流动相：乙腈/水=60/40流速：1.0 mL/min温度：35°C检测：UV 254 nm进样量：2μL样品：①尿嘧啶②苯甲酸甲酯③甲苯④萘高理论塔板数和低柱压同时实现。

Bosentan hydrate_157212-55-0_DataSheet_MedChemExpress

Product Name:Bosentan hydrate CAS No.:157212-55-0Cat. No.:HY-A0013AProduct Data SheetMWt:569.63Formula:C27H31N5O7S Purity :>98%Solubility:Mechanisms:Biological Activity:B t i titi d d l t i t f d th li 1t th d th li A (ET A)dPathways:GPCR/G protein; Target:Endothelin Receptor DMSOBosentan is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) andendothelin-B (ET-B) receptors.IC50 value:Target: ETA/ETB receptor Under normal conditions, endothelin-1 binding of ET-A or ET-B receptors causes constriction of the pulmonary blood vessels. By blocking this interaction, bosentan decreases pulmonary vascular resistance. Bosentan has a slightly higher affinity for ET-A than ET-B. Bosentan is indicated mainly for the treatment of pulmonary hypertension. In 2007, Bosentan was also approved in the European Union for reducing the number of new digital ulcers in patients with systemic sclerosis and ongoing References:[1]. Dhillon, Sohita; Keating, Gillian M. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. American Journal of Cardiovascular Drugs (2009),9(5), 331-350.Union for reducing the number of new digital ulcers in patients with systemic sclerosis and ongoing digital ulcer disease....[2]. Perez-Villa F, Farrero M, Cardona M, Castel MA, Tatjer I, Penela D, Vallejos I.Bosentan in heart transplantation candidates with severe pulmonary hypertension: efficacy, safety and outcome aftertransplantation.Clin Transplant. 2012 Aug 2.[3]. Bahde R, Kapoor S, Bandi S, Bhargava KK, Palestro CJ, Gupta S.Directly acting drugsprostacyclin or nitroglycerine and endothelin receptor blocker bosentan improve cell engraftment inrat liver.Hepatology. 2012 Aug 16.[4]. Parekh JM, Shah DK, Sanyal M, Yadav M, Shrivastav PS.Development of an SPE-LC-MS/MS method for simultaneous quantification of bosentan and its active metabolite hydroxybosentan in hum Caution: Not fully tested. For research purposes onlyMedchemexpress LLChum...18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S AE m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m。

异构醇聚氧乙烯醚硫酸铵盐

异构醇聚氧乙烯醚硫酸铵盐1 异构醇聚氧乙烯醚异构醇聚氧乙烯醚（Isotridecyl Alcohol Ethoxylate）是一种重要的表面活性剂，也是颇受关注的化工中间体，广泛应用于化工、纺织、涂料、油漆、医药、农药等行业，是目前国际上应用较为广泛的低泡、低刺激的表面活性剂之一。

异构醇聚氧乙烯醚的结构式为C13H28O（C2H4O）m（其中m为聚合度），它是一种疏水基团较大的非离子表面活性剂，具有良好的溶解性、易分散性和润湿性，它的疏水基团是异构十三烷基，可以提高其在水中的溶解度和润湿性能，并减少其表面张力，从而起到表面活性剂的作用。

2 醚硫酸铵盐醚硫酸铵盐是一种非常重要的阳离子表面活性剂，在医药、染料、皮革、纺织、塑料等行业有很广泛的应用。

它的结构式为R-O-SO3NH4+，其中R代表脂肪烷基或芳香基，通常取12-18个碳原子的烷基或苯基，它的分子结构中含有硫酸酯基和氨基，既有亲水性又有疏水性。

它的分子中含有长链脂肪基，能够增加表面张力，使它在水中形成胶束结构，从而起到表面活性剂的作用。

3 异构醇聚氧乙烯醚硫酸铵盐异构醇聚氧乙烯醚硫酸铵盐是一种复合型表面活性剂，它是将异构醇聚氧乙烯醚与硫酸铵盐完全反应制得的一种新型表面活性剂。

它既具有异构醇聚氧乙烯醚的优点，又具有硫酸铵盐的优点，具有双重的表面活性性能，被广泛应用于洗涤剂、乳化剂、染料助剂等领域。

异构醇聚氧乙烯醚硫酸铵盐的制备方法主要有两种：一种是采用异构醇聚氧乙烯醚与硫酸铵盐通过反应生成；另一种是采用异构醇与硫三氧化钨催化剂作用，先合成异构醇聚氧乙烯醚，再与硫酸铵盐反应生成。

4 异构醇聚氧乙烯醚硫酸铵盐的性能异构醇聚氧乙烯醚硫酸铵盐的性能是由其组成结构和分子量决定的。

一般来说，它具有良好的表面活性性能，可在水中形成胶束结构，并具有优异的润湿性、乳化性和稳定性。

同时，它还具有良好的耐盐度和耐硬度，不易被电解质破坏，能够在含有高浓度盐类和金属离子的环境中维持稳定性。

冠凯帕蒂柔软清洗涂层液说明书

Product #(s) – 4105Material Safety Data SheetFor Emergency Call:CHEM-TEL (800) 255-3924 24 Hour Assistance1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATIONProduct Name: C hampion Wipe-R-Clean Windshield Washer & De-IcerCAS Number: 67-56-1 / 7732-18-5Recommended Uses: Windshield WashCompany IdentificationManufacturer's Name: CHAMPION BRANDS, LLCAddress: 1001 Golden Drive, Clinton, MO 64735Telephone – General Information: (800) 821-56932. HAZARDS IDENTIFICATIONHazard Classes: Flammable Liquid Category 3Acute Oral Toxicity Category 3Acute Dermal (skin) Toxicity Category 3Acute Inhalation Toxicity Category 3Toxic to Reproduction Category 1BSpecific Target Organ Toxicity (Single Exposure) Category 1 and Category 3Aspiration Hazard Category 1Note: Assigned to classification based on human experienceSignal Word: DANGERHazard Statements:H226 Flammable Liquid and Vapor.H301 Toxic if Swallowed.H304 May be fatal if swallowed and enters airways.H311 Toxic in Contact with Skin.H331 Toxic if Inhaled.H336 May cause drowsiness or dizziness.H360 May Damage Fertility or the Unborn Child – fetotoxic and teratogenic effects.H370 Causes Damage to the Optic Nerve causing blindness if ingested. Precautionary Statements:P101 If medical advice is needed, have product container or label at hand.P102 Keep out of reach of children,P103 Read label before use.P201 Obtain special instructions before use.P202 Do not handle until all safety precautions have been read and understood. P210 Keep away from heat/sparks/open flames/hot surfaces – No smoking.P233 Keep container tightly closed.P240 Ground/bond container and receiving equipment.P241 Use explosion-proof electrical lighting and equipment.Product #(s) – 4105P242 Use only non-sparking tools.P243 Take precautionary measures against static discharge.P261 Avoid breathing vapors.P264 Wash thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P271 Use only outdoors or in a well-ventilated area.P280 Wear protective gloves / protective clothing / eye protection.P301 + P310 If SWALLOWED: Immediately call a POISON CENTER or doctor/physician.P331 D o NOT induce vomiting.P330 Rinse mouth.P303 + P361 + P353 If ON SKIN (or hair): Remove/Take of immediately all contaminated clothing.Rinse skin with water/shower.P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a positioncomfortable for breathing.P308 + P311 IF exposed or concerned: Call a POISON CENTER or doctor/physicianP361 + P378 Take off immediately all contaminated clothing and wash it before reuse.P370 + P378 In case of fire: Use dry chemical, CO2, alcohol-resistant foam, and water spray for extinction.P403 + P235 Store in well-ventilated place. Keep cool.P501 Disposal: Dispose of contents/container to a specialized waste disposal plant in accordance with local/regional regulationsHazard Pictograms:3. COMPOSITION/INFORMATION ON INGREDIENTSCAS Num b erComponents Typical WeightPercentageMethanol 22-36% 67-56-1Water 64-78% 7732-18-54. FIRST AIDEyes: If irritation or redness develops, move victim away from exposure and into fresh air. Flush eyes with clean water. If symptoms persist, seek medical attention.Skin: Remove contaminated shoes and clothing and cleanse affected area(s) thoroughly bywashing with mild soap and water. If irritation or redness develops, seek medical attention.Inhalation: If respiratory symptoms develop or other symptoms of exposure develop, move victim away from source of exposure and into fresh air. If symptoms persist, seek medical attention. If victim is not breathing, clear airway and immediately begin artificial respiration. If breathingdifficulties develop, oxygen should be administered by qualified personnel. Seek immediate medical attention.Product #(s) – 4105Ingestion: Aspiration hazard. Do not induce vomiting or give anything by mouth because thismaterial can enter the lungs and cause severe lung damage. If victim is drowsy or unconscious and vomiting, place on the left side with the head down. If possible, do not leave victim unattended and observe closely for adequacy of breathing. Seek immediate medical attention.Note to Physicians: Ethanol significantly decreases the toxicity of methanol because it competes for the same metabolic enzymes, and has been used to treat methanol poisoning.Epinephrine and other sympathomimetic drugs may initiate cardiac arrhythmias in persons exposed to high concentrations of hydrocarbon solvents (e.g., in enclosed spaces or with deliberate abuse).The use of other drugs with less arrhythmogenic potential should be considered. If sympathomimetic drugs are administered, observe for the development of cardiac arrhythmias.Medical Conditions: Exposure to high concentrations of this material may increase the sensitivity of the heart to certain drugs. Persons with pre-existing heart disorders may be more susceptible to this effect (see Note to Physician above).5. FIRE FIGHTING MEASURESSuitable Extinguishing Media: Dry chemical, CO2, water spray or alcohol-resistant foam. .Water spray is recommended to cool or protect exposed materials or structures. Water may be ineffective for extinguishment, unless used under favorable conditions by experienced fire fighters. Carbon dioxide can displace oxygen. Use caution when applying carbon dioxide in confined spaces.Specific Hazards: This material is flammable and can be ignited by heat, sparks, flames or other sources of ignition (e.g., static electricity, pilot lights or mechanical/electrical equipment). Flame is invisible in daylight. Vapors may travel considerable distances to a source of ignition where they can ignite, flashback or explode. May create vapor/air explosion hazard indoors, in confined spaces, outdoors or in sewers. If container is not properly cooled, it can rupture in the heat of a fire. Vapors are heavier than area and can accumulate in low areas.Hazardous Combustion Products: Toxic gases and vapors; oxides of carbon and formaldehyde.Special Firefighting Procedures: For fires beyond the initial stage, emergency responders in the immediate hazard area should wear bunker gear. When the potential chemical hazard is unknown, in enclosed or confined spaces, or when explicitly required by DOT, a self-contained breathingapparatus should be worn. In addition, wear other appropriate protective equipment as conditions warrant (see Section 8). Isolate immediate hazard area and keep unauthorized personnel out. Stop spill/release if it can be done with minimal risk. Move undamaged containers from immediatehazard area if it can be done with minimal risk. Water spray may be useful in minimizing ordispersing vapors and to protect personnel. Cool equipment exposed to fire with water, if it can be done with minimal risk. Avoid spreading burning liquid with water used for cooling purposes.6. ACCIDENTAL RELEASE MEASURESPersonal Precautions: Flammable. Spilling of liquid product will create a fire hazard and may form an explosive atmosphere. Keep all sources of ignition and hot metal surfaces away fromspill/release if safe to do so. The use of explosion-proof equipment is recommended. Stay upwind and away from spill/release. For large spills, notify people down-wind of spill/release, isolateimmediate hazard area and keep unauthorized personnel out. Wear appropriate protectiveequipment including respiratory protection as conditions warrant (see Section 8). See Sections 2 and 7 for additional information on hazards and precautionary measures.Product #(s) – 4105Environmental Precautions: Stop spill/release if it can be done with minimal risk. Prevent spilled material from entering sewers, storm drains, other unauthorized treatment drainage systems, and natural waterways. Use foam on spills to minimize vapors. Use water sparingly to minimizeenvironmental contamination and reduce disposal requirements. If spill occurs on water, notify appropriate authorities. Spills into or upon navigable waters, the contiguous zone, or adjoiningshorelines that cause a sheen or discoloration on the surface water, may require notification of the National Response Center (phone number 800-424-8802).Methods for Containment and Clean-Up: Notify relevant authorities in accordance with allapplicable regulations. Immediate cleanup of any spill is recommended. Dike far ahead of spill for later recovery or disposal. Absorb spill with inert material such as sand, earth or other non-combustible material, and place in suitable container for disposal. If spilled on water remove with appropriate methods (e.g., skimming, booms or absorbents). In case of soil contamination, remove contaminated soil for remediation or disposal, in accordance with local regulations.7. HANDLING AND STORAGEPrecautions for Safe Handling: Keep away from ignition sources such as heat/sparks/open flames – No smoking. Take precautionary measures against static discharge. Non-sparking tools should be used. Wear protective gloves/clothing and eye/face protection. Wash thoroughly after handling.Use good personal hygiene practices and wear appropriate personal protective equipment (see Section 8).Flammable. May vaporize easily at ambient temperatures. The vapor is heavier than air and may create an explosive mixture of vapor and air. Beware of accumulation in confined spaces and low lying areas. Open container slowly to relieve any pressure. Electrostatic charge may accumulate and create a hazardous condition when handling or processing this material. To avoid fire orexplosion, dissipate static electricity during transfer by bonding and grounding containers andequipment before transferring material. The use of explosion-proof equipment is recommended and may be required (see appropriate fire codes). Refer to NFPA-77 and/or API RP 2003 for specific bonding/grounding requirements. Do not enter confined spaces such as tanks or pits withoutfollowing proper entry procedures such as ASTM D-4276 and 29CFR 1910.146. Do not wearcontaminated clothing or shoes. Keep contaminated clothing away from sources of ignition such as sparks or open flames. Use good personal hygiene practice.Conditions for Safe Storage: Keep container(s) tightly closed. Use and store this material in cool, dry, well-ventilated areas away from heat and all sources of ignition. Post area “No Smoking or Open Flame.” Store only in approved containers. Keep away from any incompatible material (see Section 10). Protect container(s) against physical damage. Outdoor or detached storage ispreferred. Indoor storage should meet OSHA standards and appropriate fire codes.8. EXPOSURE CONTROLS/PERSONAL PROTECTIONExposure GuidelinesComponent ACGIH TLV ACGIH STEL OSHA PEL OSHA STELMethanol 200 ppm(Skin) 250 ppm(Skin)200 ppm(Skin)250 ppm(Skin)Product #(s) – 4105Engineering Controls: If current ventilation practices are not adequate to maintain airborneconcentrations below the established exposure limits, additional ventilation or exhaust systems may be required.Specific Personal Protective EquipmentEye/Face Protection: The use of eye protection that meets or exceeds ANSI Z.87.1 isrecommended to protect against potential eye contact, irritation or injury. Depending on conditions of use, a face shield may be necessary.Skin: The use of gloves impervious to the specific material handled is advised to prevent skin contact. Users should check with manufacturers to confirm the breakthrough performance of their products. Depending on exposure and use conditions, additional protection may be necessary to prevent skin contact including use of items such as chemical resistant boots, aprons, arm covers, hoods, coveralls or encapsulated suits. Suggested protective materials: butyl and nitrile rubbers.Respiratory Protection: Where there is potential for airborne exposure above the exposure limits,a NIOSH approved air purifying respirator with an organic vapor cartridge may be used.A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2requirements must be followed whenever workplace conditions warrant a respirator's use. Air- purifying respirators provide limited protection and cannot be used in atmospheres that exceed the maximum use concentration as directed by regulation or the manufacturer’s instructions, in oxygen deficient (less than 19.5% oxygen) situations or under conditions that are immediately dangerous to life and health (IDLH).Use a positive pressure air supplied respirator if there is potential for uncontrolled release, exposure levels are unknown, or any other circumstances where air-purifying respirators may not provide adequate protection.Other Protective Equipment: Eye wash and quick-drench shower facilities should be available in the work area. Thoroughly clean shoes and wash contaminated clothing before reuse.Suggestions provided in this section for exposure control and specific types of protectiv e equipment are based on readily available information. Users should consult with the specific manufacturer to confirm the performance of their protective equipment. Specific situations may require consultation with industrial hygiene, safety, or engineering professionals.9. PHYSICAL AND CHEMICAL PROPERTIES (approximate v a lues)Appearance: Clear, blue liquidOdor: Mild alcoholOdor threshold: 4.2-596 ppmpH: Not applicableMelting/Freezing Point: -97.8˚C /208˚FBoiling point (at 1 atm): 64.7˚C / 148 ˚FFlash Point: 35 ˚C / 9 ˚F (Closed Cup)Auto-Ignition Temperature: 470 ˚C / 878 ˚FEvaporation rate (butyl acetate = 1): 4.1Flammability (solid, gas): Not applicableExplosive Limits: Lower – 6%/ Upper – 36%Vapor Pressure: 92 mmHg @ 20 ˚C / 68 ˚FProduct #(s) – 4105Vapor Density (air = 1): 1.1 @ 15 ˚C / 59 ˚FSpecific gravity (H20 = 1): 0.79 @ 20˚C / 68 ˚FSolubility in water: SolublePartition Coefficient: n-octanol/water: Log P = -0.77Decomposition Temperature: No dataViscosity: 5.81 x 10-7 m2/s @ 40 ˚C / 104 ˚F10. STABILITY AND REACTIVITYStability (thermal, light, etc.): Stable under normal conditions of storage and handling.Conditions to Avoid: Avoid all possible sources of ignition (see Sections 5 and 7).Incompatibility (materials to avoid): Avoid contact with strong acids, bases and oxidizers such as liquid chlorine and oxygen. Contact with these materials may cause a violent or explosive reaction.May be corrosive to lead, aluminum, magnesium and platinum. May react with metallic aluminum or magnesium and generate hydrogen gas. May attack some forms of plastic, rubber and coatings.Hazardous Decomposition Products: Thermal decomposition may release carbon monoxide, carbon dioxide, and formaldehyde.Hazardous Polymerization: Will not occur.11. TOXICOLOGICAL INFORMATIONAcute Toxicity:Product/Ingredient Name Result Species DoseMethanol (major ingredient) LD50 OralLD50 DermalLC50 Inhalation (vapor) RatRabbitRat>2528 mg/kg17,100 mg/kg13.3 mg/l – 6hrNote: Assigned to classification based on human experience and not animal data.Skin Corrosion/Irritation: Causes mild irritation. Repeated exposure may cause dryness orcracking.Serious Eye Damage/Irritation: Causes mild irritation.Signs and Symptoms: High concentrations can cause minor respiratory irritation, headache,drowsiness, dizziness, loss of coordination, disorientation and fatigue. Ingestion can causeirritation of the digestive tract, nausea, abdominal pain, vomiting and visual disturbances ranging from blurred vision to light sensitivity, blindness or death.Skin Sensitization: None reportedRespiratory Sensitization: None reportedGerm Cell Mutagenicity: There is insufficient information available to conclude that methanol is mutagenic.Carcinogenicity: Methanol did not demonstrate carcinogenic effects in rats and mice treated via whole body inhalation at concentrations > 1.3 mg/l in air. There is insufficient informationavailable to conclude that methanol is carcinogenic. It is not listed by NTP, IARC or OSHA.Product #(s) – 4105Reproductive Toxicity: Methanol has produced fetotoxicity in rats and teratogenicity in miceexposed by inhalation to high concentrations of methanol vapors.Specific Target Organ Toxicity (Single Exposure): Methanol ingestion causes damage to the optic nerve causing blindness. May cause drowsiness and dizziness.Specific Target Organ Toxicity (Repeated Exposure): There is insufficient informationavailable to conclude that methanol causes target organ effects from repeated exposure.Aspiration Hazard: May be fatal if swallowed and enters airways.12. ECOLOGICAL INFORMATIONToxicity:Ingredient Name Result Species ExposureMethanol (major ingredient) Acute EC50 = 16.912 mg/L Marine WaterAcute LC50 = 2500000 ug/L Marine WaterAcute LC50 = 3289 mg/L Fresh WaterAcute LC50 > 100000 ug/L Fresh WaterAlgaeCrustaceansDaphniaFish96 hours48 hours48 hours96 hoursPersistence and Degradability: Methanol biodegrades easily in water and soil.BOD5 = 1.1COD = 1.05 – 1.55, 99%Bioaccumulative Potential: Risk of bioaccumulation is low (BCF <500 and low log K ow <4). BCF =0.2 - <10 Log K ow = -0.77Mobility in Soil: Methanol is highly mobile. Adsorption coefficient (K oc) solid phase/liquid phase = 1 Other Adverse Effects: None known13. DISPOSAL CONSIDERATIONSThe generator of a waste is always responsible for making proper hazardous waste determinations and needs to consider state and local requirements in addition to federal regulations.Recycle wherever possible. Large volumes may be suitable for re-distillation or, if contaminated, incinerated. Can be disposed of in a sewage treatment facility.This material, if discarded as produced, would not be a federally regulated RCRA “listed” hazardous waste. However, it would likely be identified as a federally regulated RCRA hazardous waste for the following characteristic of ignitability (D001). See Sections 7 and 8 for information on handling,storage and personal protection and Section 9 for physical/chemical properties. It is possible that the material as produced contains constituents which are not required to be listed in the MSDS but could affect the hazardous waste determination. Additionally, use which results in chemical orphysical change of this material could subject it to regulation as a hazardous waste.14. TRANSPORT INFORMATIONDOT/TDG Proper Shipping Name: Flammable Liquid n.o.s. (Methanol)Product #(s) – 4105DOT/TDG Identification Number: UN1993DOT Hazard Class: 3 / TDG Hazard Class: 3(6.1)DOT/TDG Packing Group: IIERG Guide Number: 131Marine Pollutant: No15. REGULATORY INFORMATIONTSCA: Methanol is listed on the TSCA inventory.DSL: Methanol is listed on the DSL inventory.OSHA (Occupational Safety and Health Administration): This material is considered to be hazardous as defined by the OSHA Hazard Communication Standard.This material has not been identified as a carcinogen by NTP, IARC or OSHACERCLA/SARA – Section 302 Extremely Hazardous Substances and TPQ (in pounds): This material does NOT contain chemicals subject to the reporting requirements of SARA 302 and 40 CFR 355 Appendix A and B.EPA (CERCLA) Reportable Quantity (in pounds): This material contains the following chemicals subject to the reporting requirements of 40 CFR 302.4.Component Concentration RQMethanol 22-36% 500 lbs CERCLA/SARA - Sections 311/312 (Title III Hazard Categories):Acute: Yes Chronic: Yes Fire: Yes Reactivity: NoCERCLA/SARA – Section 313 and 40 CFR 372: This material contains the following chemicals subject to the reporting requirements of SARA 313 and SARA Title III and 40 CFR:Component Concentration de minimisMethanol 22-36% 1% California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65): This material contains detectable chemicals known to the State of California to cause cancer and/or reproductive toxicity.Component Concentration EffectMethanol 22-36% Developmental Canada:This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the SDS contains all the information required by the Regulations.WHMIS Hazard Class: B2, D1B, D2A, D2B16. OTHER INFORMATIONIssue Date: May 2, 2013Previous Issue Date: May 2, 2013Change: Updated to new GHS compliant HCS 2012 criteriaProduct #(s) – 4105DISCLAIMER OF EXPRESSED AND IMPLIED WARRANTIESThe information in this document is believed to be correct as of the date issued. HOWEVER, NO WARRANTY OF MERCHANTABILITY, FITNESS FOR ANY PARTICULAR PURPOSE, OR ANY OTHER WARRANTY IS EXPRESSED OR IS TO BE IMPLIED REGARDING THE ACCURACY OR COMPLETENESS OF THIS INFORMATION, THE RESULTS TO BE OBTAINED FROM THE USE OF THIS INFORMATION OR THE PRODUCT, THE SAFETY OF THIS PRODUCT, OR THEHAZARDS RELATED TO ITS USE. This information and product are furnished on the condition that the person receiving them shall make his own determination as to the suitability of the product for this particular purpose and on the condition that he assumes the risk of his use thereof.。

美迪辛士化学产品清单表说明书

1: Identification of the substance/mixture and of the company/undertaking 1.1 Product identifier Medisanitize Universal Wipes1.2 Relevant identified uses of the substance or mixture and uses advised againstUses:Disinfection of hands and hard surfaces 1.3 Details of the supplier of the Safety Data SheetCompany name Extergeo industries ltdAddress B5 Buckshaw linkBuckshaw villageChorleyPR7 7ELUKTelephone +44(0)1772347771EmailWebsite 1.4 Emergency Telephone Number 017723477712: Hazards identification2.1 Classification of the substance or mixture2.1.1Regulation (EC) No 1272/2008(CLP)Mixture not classified as hazardous2.2 Label elements2.2.1 Label elements Contains PHMB. May produce an allergic reaction.GHS Product Identifier Medisanitize Universal WipesSignal word(s) WarningPrecautionary statement Prevention P102 - Keep out of reach of children. P103 - Read label before use.Precautionary statement: Response P101 - If medical advice is needed, have product container or label at hand.P301+P330+P331: IF SWALLOWED: Rinse mouth.P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.2.3Other hazards Not classified as PBT or vPvB.3: Composition/Information on ingredients3.1 Substances4: First-aid measures4.1Description of first aidInhalationmeasures Move affected person to fresh air at once. When breathing is difficult, properly trained personnel may assist affected person by administering oxygen. Get medical attention.Eye contact Rinse immediately with plenty of water. Remove any contact lenses and openeyelids wide apart. Continue to rinse for at least 15 minutes. Get medical attention if any discomfort continues.Skin contact Remove contaminated clothing immediately and wash skin with soap andwater. Get medical attention if any discomfort continues. Wash contaminated clothing before reuse.IngestionMove affected person to fresh air and keep warm and at rest in a position comfortable for breathing. Rinse mouth thoroughly with water. Give plenty of water to drink. Do not induce vomiting. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention immediately.4.2Most important symptoms and effects, both acute and delayed May cause irritation.5.1 Extinguishing media Suitable extinguishing media for the surrounding fire should be used.5.2Special hazards arising from the substance or mixtureCorrosive. In combustion emits toxic fumes.5.3 Advice for firefighters Standard protective equipment should be worn by fire fighters, inparticular eye / face protection.6: Accidental release measures6.1 Personal precautions, Large spillages are highly unlikely due to pre-saturation of liquid on protectiveequipment and fabric substrate. emergency procedures6.2 Environmental precautions Do not allow product to enter drains. Do not flush into surface water.6.3 Methods and material for Transfer to suitable, labelled containers for disposal. Clean spillagecontainment and cleaning up area thoroughly with plenty of water.6.4 Reference to other sections For recommended personal protective equipment see Section 8. For disposal see Section 13.7: Handling and storage7.1 Precautions for safe handling Avoid contact with eyes. Adopt best Manual Handling considerationswhen handling, carrying and dispensing.7.2 Conditions for safe storage,including any incompatibilities Keep out of the reach of children. Keep in a cool, dry, well ventilated area. Keep containers tightly closed.7.3 Specific end use No relevant information available.8: Exposure controls/personal protection8.1 Control parametersExposure controls No data availableExposure Limit Values No data available8.2 Engineering controlsRespiratory protection Keep in a cool, dry, well ventilated area.Individual protection measures None normally requiredEnvironmental exposure controls None normally required9: Physical and chemical properties9.1 Information on basic physical and chemical propertiesAppearance White nonwoven fabric pre-saturated with a colourlesssolutionOdour SpearmintpH No information available10: Stability and reactivity10.1 Reactivity Stable under normal conditions of storage/use.10.2 Chemical Stability Stable under recommended storage and handling conditions.10.3 Possibility of hazardousNone expectedreactions10.4 Conditions to avoid Avoid excessive heat. Do not allow to freeze.10.5 Incompatible materials Strong acids and Strong bases. Strong oxidising agents.In combustion emits toxic fumes10.6 Hazardous decompositionproducts11: Toxicological informationNo data available for this product12: Ecological informationNo data available for this product13: Disposal considerations13.1 Waste treatment Dispose of as special waste in compliance with local and national regulations.methods Empty containers can be sent to landfill after cleaning, if in compliance with local and national regulations.14: Transport informationThis preparation is not classified as “Hazardous” for transport purposes15: Regulatory information15.1 Safety, health and environmental regulations / legislation specific for the substance or mixture Notapplicable.Chemical Safety Assessment15.2 A chemical safety assessment has not been carried out for the substance or the mixture by the supplier.16: Other informationRevision information:Reviewed – no changesList of Abbreviations used in this SDS:CAS Chemical Abstracts ServiceCLP Classification, Labelling and Packaging Regulation (EC) no 1272/2008EC European Community/CommissionPBT Persistent, Bioaccumulative and ToxicREACH Registration, Evaluation, Authorisation and Restriction of Chemicals Regulation(EC) no 1907/2006vPvB very Persistent, very BioaccumulativeReferencesCLP Regulation 1272/2008ECHA Chem database of registered substancesSuppliers’ SDSR Phrases and H Statements used in Section 3Acute Tox. 4: H312 - Harmful in contact with skinAcute Tox. 4: H302 - Harmful if swallowed.Skin Corr. 1B: H314 - Causes severe skin burns and eye damage.Aquatic Acute 1: H400 - Harmful to aquatic lifeAquatic Chronic 2: H411 - Toxic to aquatic life with long lasting effects Carc.2: H351 - Suspected of causing cancer.Acute Tox. 2: H330 - Fatal if inhaled.STOT RE 1: H372 - Causes damage to organs through prolonged or repeated exposure.Eye Dam. 1: H318 - Causes serious eye damage.Skin Sens. 1B: H317 - May cause an allergic skin reaction.Aquatic Chronic 1: H410 - Very toxic to aquatic life with long lasting effectsTraining requirements for workersNo specific training required for workersThis Safety Data Sheet contains information concerning the potential risks to those involved in handling, transporting, and working with the material, as well as describing potential risks to the consumer and the environment. This information is based on our present state of knowledge and is intended to describe our products from the point of view of the safety requirements. It should not be construed as guaranteeing specific properties. This Safety Data Sheet is prepared in accordance with formatting described in the REACH Regulation (EC) No 1907/2006 and described in CLP Regulation (EC) No 1272/2008.。

CAS号581-05-5_α-MSH_脉铂基本说明

2、α-MSH trifluoroacetate salt技术资料：
体外研究
α-黑素细胞刺激素（MSH），酰胺是一种古老的十三肽，在所有主要形式的炎症中都具有强大的抑制活性。 α-黑素细胞刺激素（α-MSH）通过下调促炎细胞因子白细胞介素-1（IL-1），肿瘤坏死因子（TNF）-α和IL的产生和活性而起到抗炎剂的作用。 -6在免疫系统的各种细胞中表达。它还控制与炎症相关的一氧化氮产生。 α-MSH抑制由TNF和其他炎症因子诱导的核因子-κB（NF-κB）依赖性基因转录和NF-κB通路。 α-MSH的这种活性是通过产生环腺苷一磷酸（cAMP）和蛋白激酶A（PKA）酶的活化来介导的。 α-MSH作为通过NF-κB活化导致的各种病症的有效治疗剂，包括炎性疾病，AIDS中的人免疫缺陷病毒（HIV）复制（获得性免疫缺陷综合征）和败血症性休克[2]。
SR 48692
SR 48692
146362-70-1
25mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12622
Bosentan Hydrate
Bosentan Hydrate
157212-55-0
500mg
≥98%
品牌
货号
中文名称
英文名称
CAS
包装
纯度
MedBio
MED12774
≥98%
CAS号
1、α-MSH trifluoroacetate salt物理参数：
常用名
Alpha-促黑激素
英文名
α-MSH trifluoroacetate salt
CAS号
581-05-5

赛多利斯过滤-中文目录

品，以最大优化的过程设计使整个
过滤系统的流速和通透量最大化。生产验证
制定工业新标准
为了验证生产过程中使用的过滤产品，赛多利斯公司提供了全方
在我们"Plant 2001"的生产基地，我们为应用在生物技术领域的产品制定了一个新的质量标准。我们使用顶级标准为指南，按照医药产品生
位的验证支持服务。赛多利斯公司可以协助药品生产企业验证产品，完成生产过程中与过滤产品使用相关的验证。随着对药品生产管理的
Sartobran® P 滤芯
Sartobran® P
蛋白吸附极低的膜过滤器
应用领域
产品特点
● 大小输液的除菌过滤
● 双层醋酸纤维素微孔膜
● 疫苗、生物制品和抗生素的除菌过滤
● 血清、血浆分离的除菌过滤 ● 细胞培养基、诊断试剂及含有蛋
白质、维生素和防腐剂的制剂的除菌过滤 ● 超精度除菌过滤
滤芯构材
终端除菌膜过滤滤器
除菌级滤膜高度均一的多孔结构使滤膜能够以100%的截留率绝对截留颗粒和细菌。赛多利斯的除菌滤芯产品系列中适用于液体过滤的亲水滤芯有三种，分别是 Sartobran P, Sartopor e 2 和 Sartolon, 适用于气体过滤的疏水滤芯为 Sartofluor GA，可以理想地满足医药工业的各种应用需求。
● 不对称膜结构
● 血清和细胞培养液中去除支原体 (0.1μm)
● 超精度除菌过滤(0.1μm)
滤芯构材
● 双层增强型聚醚砜微孔膜 ● 耐高温的聚丙烯滤芯辅助材料
● 滤芯具有极高的流速和总通量 ● 拥有T型 MaxiCaps 工业用囊式滤器
孔径组合
0.8 + 0.45 μm 0.45 + 0.2 μm 0.2 + 0.1 μm

渗透剂材料安全数据表(MSDS)

渗透剂材料安全数据表(MSDS)渗透剂材料安全数据表（MSDS）产品信息- 产品名称：渗透剂- 化学名称：保密- 制造商：保密公司- 应急保密电话号码成分该渗透剂的具体成分构成是保密的，以保护商业机密。

然而，它不包含任何已知的有害物质。

物理性质- 外观：无色液体- 密度：（具体数值）- 沸点：（具体数值）- 燃点：（具体数值）- 溶解性：（具体描述）健康及安全信息- 吸入：避免吸入该渗透剂的蒸气。

如果吸入，请迅速转移到新鲜空气，并就医检查。

- 眼睛接触：如果渗透剂进入眼睛，请立即用大量清水冲洗至少15分钟，并咨询医生。

- 皮肤接触：若皮肤接触到该渗透剂，请立即用清水和肥皂洗净，并咨询医生。

- 意外摄入：如果渗透剂被意外摄入，请立即寻求医疗帮助。

环境信息该渗透剂对环境无明显危害。

然而，应避免将其排放到水体或土壤中。

废弃处理请遵守当地法规，将过期或废弃的渗透剂进行安全处理。

包装与储存- 包装材料：密闭- 储存条件：储存温度应保持在（具体数值）摄氏度以下，避免阳光直射和极端温度。

急救措施若意外事故发生，应立即采取以下急救措施：- 吸入：尽快将受害人转移到新鲜空气，并寻求医疗帮助。

- 眼睛接触：立即用大量清水冲洗至少15分钟。

- 皮肤接触：立即用清水和肥皂洗净受影响的皮肤区域。

- 意外摄入：立即寻求医疗帮助并遵循医生的建议。

以上是渗透剂材料安全数据表（MSDS），仅供参考。

如有疑问，请咨询产品制造商或供应商。

注意：以上信息只作为参考，不能替代专业意见和实验室测试。

使用本产品时请遵循相关法规和安全操作规程。

巴斯夫凯泽Cantus

安全技术说明书页: 1/12 巴斯夫安全技术说明书按照GB/T 16483编制日期 / 本次修订: 17.12.2021版本: 14.1日期/上次修订: 08.06.2021上次版本: 14.0日期 / 首次编制: 16.01.2006产品: 凯泽 Cantus®Product: Cantus(30174304/SDS_CPA_CN/ZH)印刷日期 11.09.20231. 化学品及企业标识凯泽 Cantus®Cantus推荐用途和限制用途: 植物保护产品, 杀真菌剂公司:巴斯夫(中国)有限公司中国上海浦东江心沙路300号邮政编码 200137电话: +86 21 20391000传真号: +86 21 20394800E-mail地址: **********************紧急联络信息:巴斯夫紧急热线中心（中国）+86 21 5861-1199巴斯夫紧急热线中心（国际）:电话: +49 180 2273-112Company:BASF (China) Co., Ltd.300 Jiang Xin Sha RoadPu Dong Shanghai 200137, CHINA Telephone: +86 21 20391000Telefax number: +86 21 20394800E-mail address: ********************** Emergency information:Emergency Call Center (China):+86 21 5861-1199International emergency number: Telephone: +49 180 2273-1122. 危险性概述纯物质和混合物的分类:对水环境的急性危害: 分类2巴斯夫安全技术说明书日期 / 本次修订: 17.12.2021版本: 14.1产品: 凯泽 Cantus®Product: Cantus(30174304/SDS_CPA_CN/ZH)印刷日期 11.09.2023标签要素和警示性说明:危险性说明:H401对水生生物有毒。

无细胞体外表达：方法和应用

• TNT® SP6 Quick Coupled Transcription/Translation System(L2081,L2080) • TNT® SP6 Coupled Reticulocyte Lysate System (L4601.L4600)
• TNT® T3 Coupled Reticulocyte Lysate System (L4950) • TNT® T7/T3 Coupled Reticulocyte Lysate System (L5010) • TNT® T7/SP6 Coupled Reticulocyte Lysate System (L5020)
oo
oo
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UUU
O NC
N OC
S NO N
加入进无细胞翻译体系中
mRNA
21
O CN
ON S N
N CO
ε N
OC
C
O
NαH3
OC N
O NN S
NC O
CO εN
O NHα3 C
C O NHα3
εN CO
N OC
O NC
S NN O
新生肽链
NH3
三种标记方法来源
• 同位素标记的氨基酸
8
复习：转录
• 原核RNA 聚合酶：全酶= 核心酶（α2ββ’）+ σ因子真核mRNA转录酶： RNA聚合酶 II
• 转录可分成3个阶段
起始启动子（真核可能有保守的TATA Box，原核Pribnow)）延伸终止 l 真核mRNA的转录后加工
l 5‘端形成帽子结构（m7GpppGp-） l 3‘端加上多聚腺苷酸尾巴（polyA tail）

Bosentan Hydrate 157212-55-0 GlpBio

Peptides, Inhibitors, AgonistsProduct Data SheetProduct Name: Bosentan HydrateCat. No.:GC11465Chemical Name: 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]benzenesulfonamide;hydrateCHEMICAL PROPERTIESCas No.: 157212-55-0Molecular Formula: C27H31N5O7SMolecular Weight: 569.63Storage: PowderSolubility: >28.5mg/mL in DMSOChemical Structure:BackgroundIC50: Inhibiting endothelin receptor A and B with an IC50 of 15.1 ± 1.6 μM in P388/dx cells.A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a relatively higher affinity to the endothelin A receptor than endothelinB receptor. By competitively binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle, Bosentan offset the effect of endothelin which is an extremely potent endogenous vasoconstrictor and broncho-constrictor. In addition, Bosentan decreases both pulmonary and systemic vascular resistance and is particularly applied in the treatment of pulmonary arterial hypertension. [1]In vitro: A study was performed in vitro to measure the influence of Bosentan on the angiogenic performance of dermal microvascular endothelial cells (MVECs) and to detect the capacity of Bosentan in offsetting the antiangiogenic effects of systemic sclerosis sera. It was found that Bosentan significantly increased cell viability and offset the antiangiogenic effects of systemic sclerosis sera on dermal MVECs. [2]In vivo: A study was conducted to investigate the effect of Bosentan on plasma leptin level after myocardial infarction in Wistar rats. After oral administration of Bosentan once daily at the dose of 100 mg/kg for 2 days, concentration of leptin in plasma significantly increased. This finding revealed that Bosentan played an crucial role on regulating leptin concentration in ischemic cardiovascular pathology. [1]Clinical trials: A double-blind, placebo-controlled clinical trial was conducted to study the effect of bosentan on exercise capacity in a larger number of patients. 213 patients with pulmonary arterial hypertension were administered with 62.5 mg Bosentan twice daily for 4 weeks followed by either of two doses of Bosentan (125 or 250 mg twice daily) for a minimum of 12 weeks. It was found that 125 mg Bosentan was well tolerated and beneficial in patients with pulmonary arterial hypertension. [3]Research Update1. Effect of Hydrofluoric Acid Concentration and Etching Time on Bond Strength to Lithium Disilicate Glass Ceramic. Oper Dent. 2017 Nov/Dec;42(6):606-615. doi: 10.2341/16-215-L. Epub 2017 Jul 14. PMID:28708007AbstractThe aim of this study was to evaluate the influence of different concentrations of hydrofluoric acid (HF) associated with varied etching times on the microshear bond strength (μSBS) of a resin cem ent to a lithium disilicate glass ceramic. Two hundred seventy-five ceramic blocks (IPS e.max Press [EMX], Ivoclar Vivadent), measuring 8 mm × 3 mm thickness, were randomly distributed into fiv e groups according to the HF concentrations (n=50): 1%, 2.5%, 5%, 7.5%, and 10%.2. Does acid etching morphologically and chemically affect lithium disilicate glass ceramic surfaces? J Appl Biomater Funct Mater. 2017 Jan 26;15(1):e93-e100. doi: 10.5301/jabfm.5000303. PMID:27647389AbstractBACKGROUND: This study evaluated the surface morphology, chemical composition and adhesiveness of lithium disilicate glass ceramic after acid etching with hydrofluoric acid or phosphoric acid.METHODS: Lithium disilicate glass ceramic specimens polished by 600-grit silicon carbide paper were subjected to one or a combination of these surface treatments: airborne particle abrasion with 50-μm alumina (AA), etching with 5% hydrofluoric acid (HF) or 36% phosphoric acid (Phos), and application of silane coupling age nt (Si).3. Fatigue failure load of feldspathic ceramic crowns after hydrofluoric acid etching at different concentrations. J Prosthet Dent. 2018 Feb;119(2):278-285. doi: 10.1016/j.prosdent.2017.03.021. Epub 2017 May 26. PMID:28552291AbstractSTATEMENT OF PROBLEM: Hydrofluoric acid etching modifies the cementation surface of ceramic restorations, which is the same surface where failure is initiated. Information regarding the influence of hydrofluoric acid etching on the cyclic loads to failure of ceramic crowns is lacking.PURPOSE: The purpose of this in vitro study was to evaluate the influence of different hydrofluoric acid concentrations on the fatigue failure loads of feldspathic ceramic crowns.。

TITANIUM DIOXIDE COATED WITH SILICON DIOXIDE

专利名称：TITANIUM DIOXIDE COATED WITH SILICON DIOXIDE发明人：SCHUMACHER, Kai,BATZ-SOHN,Christoph,HASENZAHL, Steffen申请号：EP2003013534申请日：20031202公开号：WO04/056927P1公开日：20040708专利内容由知识产权出版社提供摘要：Powder consisting of particles with a core of titanium dioxide and a coating of silicon dioxide, which powder has a content of silicon dioxide of between 0.5 and 40 wt.%, a BET surface of between 5 and 300 m2/g, and which consists of primary particles that have a coating of silicon dioxide and a core of titanium dioxide. The powder is produced according to a process in which a vaporisable silicon compound and a vaporisable titanium compound are mixed corresponding to the subsequently desired ratio of SiO2 and TiO2 in the product, are vaporised at temperatures of 200°C or less, and conveyed by means of an inert gas stream together with hydrogen and air or with oxygen-enriched air to the central pipe (core) of a known burner, the reaction mixture is ignited at the mouth of the burner and introduced together with secondary air, is combusted in a cooled flame pipe, following which the titanium dioxide powder coated with silicon dioxide is separated from the gaseous reaction products and if necessary is freed in moist air from adhering hydrogen chloride, the ratio of primary air to secondary air being greater than 0.3, the ratio of core hydrogen to secondary air being greater than 1, and the ratio of titanium dioxide precursor to secondary air being greater than 0.5. Sunscreen agent containing thepowder in an amount of between 0.01 and 25 wt.%.申请人：SCHUMACHER, Kai,BATZ-SOHN, Christoph,HASENZAHL, Steffen 地址：DE,DE,DE,US国籍：DE,DE,DE,US代理机构：DEGUSSA AG更多信息请下载全文后查看。

高效液相色谱-串联质谱法检测泮托拉唑钠原料药中的水合肼

·药物研发·高效液相色谱-串联质谱法检测泮托拉唑钠原料药中的水合肼赵会明张振洋樊华军［英格尔检测技术服务（上海）有限公司上海 201100］摘要建立了泮托拉唑钠原料药中的基因毒性杂质水合肼的高效液相色谱-串联质谱（LC-MSMS）检测方法。

采用反相色谱，以水-乙腈（含0.1%甲酸）为流动相，梯度洗脱，流速0.5 mL/min，以ESI正离子多反应监测（MRM）模式进行质谱检测。

结果显示，水合肼的检测限和定量限可达到0.23、0.47 ng/mL，其在0.47~9.37 ng/mL浓度范围内线性关系良好（r=0.999 9），准确度试验中低、中、高浓度回收率均在81.6%~90.9%之间。

在3批次泮托拉唑钠原料药中均未检出水合肼。

关键词高效液相色谱-串联质谱法基因毒性杂质泮托拉唑钠水合肼痕量检测中图分类号：R917; O657 文献标志码：A 文章编号：1006-1533(2022)11-0072-04引用本文赵会明, 张振洋, 樊华军. 高效液相色谱-串联质谱法检测泮托拉唑钠原料药中的水合肼[J]. 上海医药, 2022, 43(11): 72-75.Determination of hydrazine hydrate in pantoprazole sodium by high performance liquid chromatography-tandem mass spectrometryZHAO Huiming, ZHANG Zhenyang, FAN Huajun[ICAS Testing Technology Service (Shanghai) CO., LTD., Shanghai 201100, China]ABSTRACT To establish a high-performance liquid chromatography-tandem mass spectrometry (LC-MSMS) method for the determination of hydrazine hydrate in active pharmaceutical ingredient (API) pantoprazole sodium. HPLC was carried out by reverse chromatography using water-acetonitrile containing 0.1% formic acid as flow phase and gradient elution at a flow rate of 0.5 mL/min. Mass spectrometry was performed with multi-reaction monitoring (MRM) in positive ESI mode. The detection and quantitative limits of hydrazine hydrate reached 0.23, 0.47 ng/mL and hydrazine hydrate showed good linear relationship in the range of 0.47-9.37 ng/mL (r=0.999 9). The recoveries of samples at low, medium and high-level concentrations reached81.6% to 90.9% in the accuracy experiment. No hydrazine hydrate was detected in 3 batches of pantoprazole sodium.KEY WORDS HPLC-tandem mass spectrometry; genotoxic impurities; pantoprazole sodium; hydrazine hydrate; trace determination上消化道出血是近年的临床疾病中常见且多发的一种疾病，其临床表现为呕血、黑便等，如得不到及时有效治疗，可能引发失血性休克。