Metrifonate_SDS_MedChemExpress
碧云天细胞自噬染色检测试剂盒(MDC法)说明书
细胞自噬染色检测试剂盒(MDC 法)产品简介:碧云天生产的细胞自噬染色检测试剂盒(MDC 法),即Autophagy Staining Assay Kit with MDC ,是一种使用丹酰尸胺,也称单丹磺酰尸胺、丹酰尸胺或丹酰戊二胺(monodansylcadaverine, MDC)作为荧光探针快速便捷地检测细胞自噬的试剂盒。
自噬(autophagy)是一种在进化上高度保守的通过溶酶体吞噬并降解部分自身组分的细胞内分解代谢途径。
自噬与多种生理功能有关,在饥饿等环境条件下,细胞通过自噬降解多余或异常的细胞内组分,为细胞的生存提供能量及原材料,促进生物体的生长发育、细胞分化及对环境变化产生应答。
自噬异常与多种病理过程如肿瘤、神经退行性疾病、代谢疾病、病原体感染等都有密切关系。
由于细胞自噬在生理和病理过程中都有重要作用,自噬已经成为细胞生物学领域的一个研究热点。
MDC 是细胞自噬检测最常用的荧光探针之一。
MDC 可以通过离子捕获(ion trapping)和与膜脂的特异性结合,从而特异性标记自噬体(autophagosome),也称autophagic vacuole ,因而常用于细胞自噬的检测。
MDC 是一种嗜酸性荧光探针,很多酸性膜性结构也会被MDC 染色,因此MDC 染色时正常的细胞也会有一定的染色背景。
本产品的染色原理决定了本产品只能用于培养的细胞或者组织的细胞自噬荧光染色检测,不能用于冻存的或固定的细胞、组织或者组织切片的染色检测。
使用本产品染色后可以通过荧光显微镜拍照观察,也可以通过荧光酶标仪或流式细胞仪进行荧光检测。
荧光显微镜观察时可以使用紫外区激发光激发,发出绿色荧光。
荧光酶标仪或流式细胞仪推荐的激发波长为335nm (330-360nm 均可),发射波长为512nm (510-540nm 均可)。
本产品用于细胞自噬染色的效果参考图1。
图1. 细胞自噬染色检测试剂盒(MDC 法)的染色效果图。
棕榈酰化修饰鉴定
棕榈酰化修饰鉴定棕榈酰化修饰是蛋白质修饰的一种类型,它是指通过在蛋白质分子上加入棕榈酸分子,改变蛋白质的分布和功能的过程。
棕榈酰化修饰的研究已经成为细胞生物学和信号转导领域的热点,对于深入理解细胞的生物学功能以及相关疾病的发生机制具有重要意义。
在棕榈酰化修饰的研究中,最关键的问题是如何鉴定和定量棕榈酰化的蛋白质。
以下是一些常用的鉴定方法:1. 蛋白质质谱分析蛋白质质谱分析是目前最常用的蛋白质棕榈酰化修饰鉴定方法。
通过比较已知棕榈酰化的蛋白质和未知样品的质谱数据,确定分子量、肽段质量等信息来进行鉴定。
但是,这种方法需要在蛋白质水解前进行棕榈酰化鉴定,且需要在非常灵敏的质谱设备上操作,因此受到样品制备和设备设置等因素的影响。
2. 免疫印迹法免疫印迹法也是常用的棕榈酰化修饰鉴定方法之一。
该方法利用特异抗体识别棕榈酰化蛋白,通过检测特定的蛋白质带来确定棕榈酰化修饰的存在。
但是,这种方法可以检测到多个棕榈酰化位点,需要进行多次实验来确定位点,并且受到抗体的特异性和灵敏性等因素的限制。
3. 化学探针法化学探针法是一种直接检测棕榈酰化修饰蛋白质的方法。
该方法利用化学探针针对棕榈酰化蛋白质的棕榈基进行修饰,然后通过荧光探针、质谱等技术检测探针修饰的蛋白质。
这种方法直接、快速,可以同时检测多个样品,但需要合成高效的化学探针,且探针的结构和修饰条件对结果具有显著影响。
4. DNA微阵列技术DNA微阵列技术是一种可高通量鉴定蛋白质棕榈酰化的方法。
该方法通过在DNA微阵列上固定已知棕榈酰化有代表性的蛋白质、蛋白质片段或合成多肽来印制芯片,然后通过检测待鉴定样品与芯片上蛋白质片段的结合程度来确定棕榈酰化蛋白的鉴定结果。
但是,该方法需要具备棕榈酰化相关蛋白质序列,且对于未知的棕榈酰化修饰位点鉴定有限。
总结来看,各个方法都有其优缺点,在棕榈酰化修饰的研究中,根据具体的实验目的和需求选择合适的方法,或采取多种方法相结合的策略来进行鉴定和定量。
药剂学(崔福德主编_第七版)
药剂学常考试题集锦一、名词解释1.Critical micelle concentration (CMC):临界胶束浓度,表面活性剂分子缔合形成胶束的最低浓度即为临界胶束浓度。
(A卷考题)P372.Krafft point:即克拉夫特点,离子型表面活性剂在温度较低时溶解度很小,但随温度升高而逐渐增加,当到达某一特定温度时,溶解度急剧陡升,把该温度称为克拉夫特点。
(A卷考题)P413. cloud poing: 即昙点,也称为浊点,某些含聚氧乙烯基的非离子表面活性剂的溶解度开始随温度上升而加大,到某一温度后其溶解度急剧下降,使溶液变混浊,甚至产生分层,但冷后又可恢复澄明。
这种由澄明变混浊的现象称为起昙,这个转变温度称为昙点。
(B卷考题)P424.助溶:系指难溶性药物与加入的第三种物质在溶剂中形成可溶性分子络合物、复盐或分子缔合物等,以增加药物在溶剂中溶解度的过程。
(A卷和B卷考题)5、脂质体:是指将药物包封于类脂质双分子层形成的薄膜中间所制成的超微型球状体,是一种类似微型胶囊的新剂型。
(B卷考题)6.碘值:脂肪不饱和程度的一种度量,等于100g脂肪所摄取碘的克数。
检测时,以淀粉液作指示剂,用标准硫代硫酸钠液进行滴定。
碘值大说明油脂中不饱和脂肪酸含量高或其不饱和程度高。
7. 酸值:酸值又称酸价。
是指中和1g天然脂肪中的游离酸所需消耗氢氧化钾的毫克数。
酸值的大小反映了脂肪中游离酸含量的多少。
P1948.Pyrogen: 热原,是微生物的代谢产物。
热原=内毒素=脂多糖。
9.增溶10. 置换价11. F0值12. Prodrug:前体药物,也称前药、药物前体、前驅藥物等,是指经过生物体内转化后才具有药理作用的化合物。
前体药物本身没有生物活性或活性很低,经过体内代谢后变为有活性的物质,这一过程的目的在于增加药物的生物利用度,加强靶向性,降低药物的毒性和副作用。
目前前体药物分为两大类:载体前体药物(carrier-prodrug)和生物前体(bioprecursor)。
Gelucire-14-44-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Nov.-23-2018Print Date:Nov.-23-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Gelucire 14/44Catalog No. :HY-Y1892CAS No. :121548-04-71.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:N/AMolecular Weight:N/ACAS No. :121548-04-74. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Pure form-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Oil)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Erythromycin-Cyclocarbonate-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Oct.-02-2018Print Date:Oct.-02-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Erythromycin CyclocarbonateCatalog No. :HY-100584CAS No. :55224-05-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4),H302Acute aquatic toxicity (Category 1),H400Chronic aquatic toxicity (Category 1),H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effects.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor ⁄ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents ⁄ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:Erythromycin cyclic carbonate;Erythromycin A 11,12-carbonateFormula:C38H65NO14Molecular Weight:759.92CAS No. :55224-05-04. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077Class: 9Packing group: IIIEMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutant.IATAUN number: 3077Class: 9Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
美国Medchemexpress化合物库(小分子库)_Medchemexpress_(MCE中国)
美国Medchemexpress化合物库(小分子库)-原装进口,现货供
应,提供组合定制服务
品牌:Medchemexpress (MCE)
保存条件:-20℃
供应商:MCE中国
数量:大量
保质期:2年
Size:
Pre-dissolved DMSO/Solid(Or dry solid)
100 uL/well (10 mM solution)
200 uL/well (10 mM solution)
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生化-酶汇总
名称类型功能反应物GSH过氧化物酶氧化谷胱甘肽的还原作用谷胱甘肽(GSH)、H2O2 GSH还原酶还原谷胱甘肽的还原作用G SSG己糖激酶磷酸化糖酵解途径葡萄糖、ATP葡萄糖激酶磷酸化糖酵解途径葡萄糖、ATP磷酸己糖异构酶异构糖酵解途径6-磷酸葡萄糖6-磷酸果糖激酶-1磷酸化糖酵解途径6-磷酸果糖醛缩酶裂解糖酵解途径1,6-二磷酸果糖磷酸丙糖异构酶异构糖酵解途径磷酸二羟丙酮3-磷酸甘油醛脱氢酶底磷化糖酵解途径3-磷酸甘油醛、Pi磷酸甘油酸激酶底磷化糖酵解途径1,3-二磷酸甘油酸、ADP磷酸甘油酸变位酶异构糖酵解途径3-磷酸甘油酸烯醇化酶脱水糖酵解途径2-磷酸甘油酸丙酮酸激酶脱磷酸糖酵解途径磷酸烯醇式丙酮酸、ADP乳酸脱氢酶(LDHⅠ)加氢糖酵解丙酮酸乳酸脱氢酶(LDHⅤ)脱氢糖异生乳酸6-磷酸果糖激酶-2磷酸化糖酵解调节6-磷酸果糖、ATP果糖二磷酸酶-2脱磷酸糖酵解调节2,6-二磷酸果糖、H2O丙酮酸脱氢酶(E1)脱氢丙酮酸氧化脱羧丙酮酸、TPP二氢硫辛酸转乙酰酶(E2)转乙酰丙酮酸氧化脱羧羟乙基TPP、硫辛酸、CoASH 二氢硫辛酸脱氢酶脱氢丙酮酸氧化脱羧二氢硫辛酸柠檬酸合酶转羧基三羧酸循环草酰乙酸、乙酰CoA、H2O 顺乌头酸酶异构三羧酸循环柠檬酸异柠檬酸脱氢酶氧化脱羧三羧酸循环异柠檬酸α-酮戊二酸脱氢酶(复合体)氧化脱羧三羧酸循环α-酮戊二酸、CoASH琥珀酰CoA合成酶(琥珀酸硫激酶)底磷化三羧酸循环琥珀酰CoA、GDP、Pi琥珀酸脱氢酶脱氢三羧酸循环琥珀酸延胡索酸酶加水三羧酸循环延胡索酸、H2O苹果酸脱氢酶脱氢三羧酸循环苹果酸6-磷酸葡萄糖脱氢酶脱氢磷酸戊糖途径6-磷酸葡萄糖6-磷酸葡萄糖酸δ内酯酶(内酯酶)水解磷酸戊糖途径6-磷酸葡萄糖内酯、H2O6-磷酸葡萄糖酸脱氢酶脱氢磷酸戊糖途径6-磷酸葡萄糖酸(异构酶)异构磷酸戊糖途径5-磷酸核酮糖丙酮酸羧化酶羧化糖异生途径丙酮酸、ATP、CO2磷酸烯醇式丙酮羧激酶羧化糖异生途径草酰乙酸、GTP谷草转氨酶转氨基糖异生草酰乙酸,谷氨酸果糖二磷酸酶-1脱磷酸糖异生途径1,6-二磷酸果糖、H2O葡萄糖-6-磷酸酶水解糖异生途径6-磷酸葡萄糖、H2O磷酸葡萄糖变位酶异构糖原合成6-磷酸葡萄糖UDPG焦磷酸化酶水解糖原合成1-磷酸葡萄糖、UTP糖原合成酶(误:糖原合酶)合成糖原合成糖原分支酶异构糖原合成糖原糖原磷酸化酶水解糖原分解糖原脱支酶1(葡萄糖转移酶)异构糖原分解糖原(分支)脱支酶2(α-1,6-葡萄糖苷酶)水解糖原分解糖原ALA合酶转酰基血红素合成琥珀酰CoA、甘氨酸ALA脱水酶脱水缩合血红素合成ALA卟胆原脱氨酶脱氨血红素合成卟胆原(PBG)尿卟啉原Ⅲ同合酶脱氨血红素合成线状四吡咯尿卟啉原Ⅲ脱羧酶脱羧血红素合成尿卟啉原Ⅲ粪卟啉原Ⅲ氧化脱羧酶氧化脱羧血红素合成粪卟啉原Ⅲ原卟啉原Ⅸ氧化酶氧化血红素合成原卟啉原Ⅸ亚铁螯合酶结合血红素合成原卟啉Ⅸ二磷酸甘油酸变位酶异构2,3-BPG支路1,3-二磷酸甘油酸二磷酸甘油酸磷酸酶水解2,3-BPG支路2,3-BPG(2,3-二磷酸甘油酸)、复合体Ⅰ:NADH-Q还原酶脱电子呼吸链NADH、H+、CoQ复合体Ⅱ:琥珀酸-Q还原酶脱电子呼吸链FADH2、CoQ复合体Ⅲ:细胞色素还原酶脱电子呼吸链QH2,细胞色素c复合体Ⅳ:细胞色素氧化酶脱电子呼吸链还原性细胞色素c、氧原子ATP合成酶(ATP合酶)磷酸化呼吸链ADP、Piα-磷酸甘油脱氢酶加氢α-磷酸甘油穿梭磷酸二羟丙酮、H+α-磷酸甘油脱氢酶*脱氢α-磷酸甘油穿梭α-磷酸甘油、CoQ过氧化氢酶氧化线粒体外氧化体系H2O2过氧化物酶氧化线粒体外氧化体系H2O2、R超氧化物歧化酶(SOD)氧化线粒体外氧化体系H+、O2-胰脂酶水解脂类的消化三酰甘油、H2O磷脂酶A2水解脂类的消化磷脂、H2O胆固醇酯酶水解脂类的消化胆固醇酯脂酰CoA合成酶转酰基甘油一酯途径脂肪酸、CoASH、ATP脂酰CoA转移酶转酰基甘油一酯途径2-单酰甘油、脂酰CoA三酰甘油脂肪酶水解脂肪动员三酰甘油、H2O二酰甘油脂肪酶水解脂肪动员二酰甘油、H2O单酰甘油脂肪酶水解脂肪动员单酰甘油、H2O脂酰CoA合成酶*转酰基脂肪酸β-氧化脂肪酸、CoASH、ATP肉碱脂酰转移酶Ⅰ转酰基脂肪酸β-氧化脂酰CoA、肉碱肉碱-脂酰肉碱转位酶转酰基?脂肪酸β-氧化脂酰肉碱(外)、肉碱(内)肉碱脂酰转移酶Ⅱ转酰基脂肪酸β-氧化CoASH、脂酰肉碱脂酰CoA脱氢酶脱氢脂肪酸β-氧化脂酰CoA(C n+2)烯脂酰CoA水合酶加水脂肪酸β-氧化反式⊿2-烯脂酰CoA、H2Oβ-羟脂酰脱氢酶脱氢脂肪酸β-氧化L(+)-β-羟脂酰CoA(β-酮脂酰)硫解酶硫解脂肪酸β-氧化β-酮脂酰CoA、CoASH丙酰CoA羧化酶等羧化、异构奇碳脂肪酸氧化丙酰CoA、CO2、ATP乙酰乙酰CoA硫解酶转酰基酮体生成乙酰CoAHMG-CoA合酶缩合酮体生成乙酰乙酰CoA、乙酰CoA、H2O HMG-CoA裂解酶分解酮体生成HMG-CoAβ-羟基丁酸脱氢酶加氢酮体生成乙酰乙酸β-羟基丁酸脱氢酶*脱氢酮体氧化β-羟基丁酸琥珀酰CoA转硫酶转酰基酮体氧化乙酰乙酸、琥珀酰CoA乙酰乙酸硫激酶转酰基酮体氧化乙酰乙酸、CoASH、ATP乙酰乙酰CoA硫解酶*转酰基酮体氧化乙酰乙酰CoA、CoASH甘油磷酸激酶磷酸化甘油氧化分解甘油、ATP磷酸甘油脱氢酶脱氢甘油氧化分解3-磷酸甘油柠檬酸裂解酶转酰基柠檬酸-丙酮酸循环柠檬酸、CoASH、ATP苹果酸酶脱羧柠檬酸-丙酮酸循环苹果酸乙酰CoA羧化酶羧化脂肪酸合成乙酰CoA、ATP、CO2、H2O乙酰基转移酶转酰基脂肪酸合成乙酰CoA、(β-酮脂酰合酶)丙二酰转移酶转酰基脂肪酸合成乙酰-酶复合物、丙二酰CoAβ-酮脂酰合酶脱羧脂肪酸合成乙酰-丙二酰-酶复合物β-酮脂酰还原酶加氢脂肪酸合成β-酮脂酰~S-ACPβ-羟脂酰脱水酶(水合酶)脱水脂肪酸合成β-羟基丁酰~S-ACPΔ2-烯脂酰还原酶加氢脂肪酸合成Δ2-烯脂酰~S-ACP长链脂酰硫酯酶水解脂肪酸合成软脂酰~S-ACP、H2O脂肪酸合成酶系合成脂肪酸合成乙酰CoA、丙二酰CoA、ATP、C (人)脂肪酸去饱和酶脱氢不饱和脂酸合成饱和脂肪酸脂酰CoA转移酶*转酰基甘油二酯途径3-磷酸甘油、脂酰CoA磷脂酸磷脂酶脱磷酸甘油二酯途径磷脂酸脂酰CoA转移酶*2转酰基甘油二酯途径1,2-甘油二酯、脂酰CoA CTP:磷酸乙醇胺胞苷转移酶转苷甘油二酯合成途径磷酸乙醇胺、CTPCTP:磷酸胆碱胞苷转移酶转苷甘油二酯合成途径磷酸胆碱、CTP(转移酶)转苷甘油二酯合成途径1,2-甘油二酯、CDP-磷酸乙醇(转移酶)*转苷甘油二酯合成途径1,2-甘油二酯、CDP-磷酸乙醇心磷脂合成酶转苷CDP-甘油二酯合成途C DP-甘油二酯、磷脂酰甘油磷脂酰肌醇合成酶转苷CDP-甘油二酯合成途C DP-甘油二酯、磷脂酰肌醇乙酰乙酰CoA硫解酶*转酰基甲羟戊酸途径乙酰CoAHMG-CoA合酶*缩合甲羟戊酸途径乙酰乙酰CoA、乙酰CoA、H2O甲羟戊酸途径HMG-CoAHMG-CoA还原酶加氢、脱酰基胆固醇合成甲羟戊酸(鲨烯合成酶系)Ⅰ磷酸化、脱羧(鲨烯合成酶系)Ⅱ异构、缩合胆固醇合成异戊烯焦磷酸(5C)胆固醇合成鲨烯(30C)(形成胆固醇酶系)环化、脱羧等脂酰CoA胆固醇脂酰转移酶(ACAT)转酰基胆固醇酯化胆固醇、脂酰CoA卵磷脂胆固醇脂酰转移酶(LCAT)转酰基胆固醇酯化胆固醇、卵磷脂脂蛋白脂肪酶水解血浆脂蛋白代谢CM\VLDL肝脂肪酶水解血浆脂蛋白代谢CM残粒\VLDL残粒加单氧酶系氧化肝的生物转化ⅠRH、O2单胺氧化酶系氧化肝的生物转化Ⅰ胺、O2、H2O脱氢酶系:肝细胞醇脱氢酶氧化肝的生物转化Ⅰ乙醇脱氢酶系:醛脱氢酶氧化肝的生物转化Ⅰ乙醛硝基还原酶还原肝的生物转化Ⅰ硝基化合物偶氮还原酶还原肝的生物转化Ⅰ偶氮化合物水解酶系水解肝的生物转化Ⅰ酯类\酰胺类\糖苷类化合物、UDP-葡萄糖醛酸转移酶转酰基肝的生物转化Ⅱ醇\酚\胺\羧酸类化合物、UDP 硫酸转移酶转酰基肝的生物转化Ⅱ类固醇\酚\胺\芳香胺类化合物谷胱甘肽S-转移酶转酰基肝的生物转化Ⅱ芳香卤类\烷烃基\硝基化合物乙酰转移酶转酰基肝的生物转化Ⅱ芳香胺类化合物、乙酰CoA氨基酸N-酰基转移酶转酰基肝的生物转化Ⅱ自由羧基化合物、乙酰CoA甲基转移酶转酰基肝的生物转化Ⅱ羟基\硫基\氨基化合物、SAM 7α-羟化酶羟化游离胆汁酸生成胆固醇、O2微粒体血红素加氧酶加氧胆红素生成血红素、O2胆绿素还原酶加氢胆红素生成胆绿素UDP-葡萄糖醛酸转移酶*转酰基结合胆红素生成胆红素、UDPGA(肠菌酶)脱离胆素生成胆红素葡萄糖醛酸酯磷酸核糖焦磷酸激酶磷酸化PRPP的生成5-磷酸核糖、ATPIMP的合成PRPP、谷氨酰胺、H2OPRPP酰胺转移酶脱磷酸、转酰GAR合成酶缩合IMP的合成5-PRA、甘氨酸、ATPGAR甲酰转移酶转酰基IMP的合成GAR、N10-甲酰FH4FGAM合成酶亚氨基化IMP的合成FGAR、谷氨酰胺、ATPAIR合成酶环化IMP的合成FGAM、ATPAIR羧化酶羧化IMP的合成AIR、CO2、ATPSAICAR合成酶缩合IMP的合成CAIR、天冬氨酸、ATP SAICAR裂解酶水解IMP的合成SAICAR、H2OAICAR甲酰转移酶转酰基IMP的合成AICAR、N10-甲酰FH4次黄嘌呤核苷酸合成酶环化IMP的合成FAICAR腺苷酸代琥珀酸合成酶缩合AMP的合成IMP、天冬氨酸、GTP腺苷酸代琥珀酸裂解酶水解AMP的合成腺苷酸代琥珀酸、H2OIMP脱氢酶脱氢GMP的合成IMP、H2OGMP合成酶亚氨基化GMP的合成XMP、谷氨酰胺、ATP(激酶)磷酸化NTP的生成NMP\dNMP、Pi腺嘌呤磷酸核糖转移酶(APRT)转移嘌呤核苷酸补救合成腺嘌呤、PRPP次黄嘌呤-鸟嘌呤磷酸核糖转移酶(HG转移嘌呤核苷酸补救合成次黄嘌呤\鸟嘌呤、PRPP腺苷激酶磷酸化嘌呤核苷酸补救合成腺苷、ATP核苷酸酶脱磷酸嘌呤核苷酸降解AMP\GMP核苷脱氨酶脱氨嘌呤核苷酸降解腺苷嘌呤核苷酸降解次黄苷\鸟苷、Pi嘌呤核苷磷酸化酶磷酸化、水解黄嘌呤氧化酶氧化嘌呤核苷酸降解次黄嘌呤、O2、H2O鸟嘌呤脱氨酶脱氨嘌呤核苷酸降解鸟嘌呤、H2O黄嘌呤氧化酶*氧化嘌呤核苷酸降解黄嘌呤、O2、H2O氨基甲酰磷酸合成酶Ⅱ(CPSⅡ)缩合、磷酸化UMP的合成ATP、CO2、H2O、谷氨酰胺UMP的合成氨基甲酰磷酸、天冬氨酸天冬氨酸氨基甲酰转移酶(ATCase)脱磷酸、缩合二氢乳清酸酶环化UMP的合成氨基酰天冬氨酸二氢乳清酸脱氢酶脱氢UMP的合成二氢乳清酸嘧啶磷酸核糖转移酶转移UMP的合成乳清酸、PRPPOMP脱羧酶脱羧UMP的合成乳清酸核苷酸(OMP)CTP合成酶氨基化CTP的合成UTP、谷氨酰胺、ATP嘧啶磷酸核糖转移酶*转移嘧啶核苷酸补救合成嘧啶、PRPP尿苷激酶磷酸化嘧啶核苷酸补救合成尿嘧啶核苷、ATP(脱氨基酶)脱氨嘧啶核苷酸分解代谢胞嘧啶、H2O嘧啶核苷酸分解代谢尿嘧啶、H2O尿嘧啶分解酶系加氢、开环、嘧啶核苷酸分解代谢胸腺嘧啶、H2O胸腺嘧啶分解酶系加氢、开环、核糖核苷酸还原酶还原脱氧核苷酸的生成NDP、还原型硫氧还蛋白硫氧还蛋白还原酶还原脱氧核苷酸的生成氧化型硫氧还蛋白γ-谷氨酰基转移酶转酰基γ-谷氨酰基循环谷胱甘肽(GSH)、氨基酸γ-谷氨酸环化转移酶水解、环化γ-谷氨酰基循环γ-谷氨酰氨基酸5-氧脯氨酸酶水解γ-谷氨酰基循环5-氧脯氨酸、ATP(肽酶)水解γ-谷氨酰基循环半胱氨酰甘氨酸γ-谷氨酰半胱氨酸合成酶合成γ-谷氨酰基循环半胱氨酸、谷氨酸、ATP谷胱甘肽合成酶合成γ-谷氨酰基循环γ-谷氨酰半胱氨酸、甘氨酸、ATP 泛素活化酶转酰基泛素介导的蛋白质降泛素、泛素活化酶、ATP泛素-泛素活化酶转酰基泛素介导的蛋白质降泛素-泛素活化酶、泛素载体蛋泛素-蛋白连接酶转酰基泛素介导的蛋白质降蛋白质、泛素-泛素载体蛋白丙氨酸氨基转移酶(ALT)转氨基转氨基作用谷氨酸、丙酮酸心肌天冬氨酸氨基转移酶(AST)转氨基转氨基作用谷氨酸、草酰乙酸L-谷氨酸脱氢酶脱氢、脱氨氧化脱氨基作用L-谷氨酸、H2O谷氨酰胺合成酶氨基化氨的储存和运输NH3、谷氨酸谷氨酰胺酶脱氨氨的储存和运输谷氨酰胺氨基甲酰磷酸合成酶Ⅰ(CPSⅠ)合成尿素合成H2O、CO2、NH3、ATP鸟氨酸氨基甲酰转移酶(OCT)转酰基尿素合成鸟氨酸、氨基甲酰磷酸精氨酸代琥珀酸合成酶(ASS)缩合尿素合成瓜氨酸、天冬氨酸、ATP精氨酸代琥珀酸裂解酶(ASL)裂解尿素合成精氨酸代琥珀酸精氨酸酶水解尿素合成精氨酸、H2O(氨基酸脱羧酶)脱羧氨基酸脱羧基作用氨基酸L-谷氨酸脱羧酶脱羧氨基酸脱羧基作用L-谷氨酸磺酸丙氨酸脱羧酶脱羧氨基酸脱羧基作用磺酸丙氨酸组氨酸脱羧酶脱羧氨基酸脱羧基作用L-组氨酸色氨酸羟化酶羟化氨基酸脱羧基作用色氨酸5-羟色胺酸脱羧酶脱羧氨基酸脱羧基作用5-羟色氨酸鸟氨酸脱羧酶脱羧氨基酸脱羧基作用鸟氨酸SAM脱羧酶脱羧氨基酸脱羧基作用S-腺苷甲硫氨酸(SAM)氨丙基转移酶转移氨基酸脱羧基作用腐胺、脱羧基SAM氨丙基转移酶*转移氨基酸脱羧基作用亚精胺(精脒)、脱羧基SAM 二氢叶酸合成酶合成一碳单位代谢二氢蝶呤啶、对氨基苯甲酸、二氢叶酸还原酶还原一碳单位代谢FH2、[H]?腺苷转移酶转移含硫氨基酸代谢蛋氨酸、ATP甲基转移酶转甲基含硫氨基酸代谢S-腺苷甲硫氨酸(SAM)、甲基腺苷同型半胱氨酸酶水解含硫氨基酸代谢S-腺苷同型半胱氨酸、H2O甲基转移酶*转甲基含硫氨基酸代谢同型半胱氨酸、甲基FH4脒基转移酶转移肌酸和磷酸肌酸代谢精氨酸、甘氨酸甲基转移酶*2转甲基肌酸和磷酸肌酸代谢胍乙酸、S-腺苷甲硫氨酸(SA 肌酸激酶(CK)磷酸化肌酸和磷酸肌酸代谢肌酸、ATP(肌酸环化酶)环化肌酸和磷酸肌酸代谢肌酸(磷酸肌酸脱磷酸酶)脱磷酸肌酸和磷酸肌酸代谢磷酸肌酸苯丙氨酸羟化酶羟化芳香族氨基酸代谢苯丙氨酸、O2、FH4苯丙氨酸转氨酶转氨基芳香族氨基酸代谢苯丙氨酸酪氨酸羟化酶羟化芳香族氨基酸代谢酪氨酸酪氨酸酶羟化芳香族氨基酸代谢酪氨酸酪氨酸转氨酶转氨基芳香族氨基酸代谢酪氨酸(支链氨基酸转氨酶)转氨基支链氨基酸代谢(缬氨酸、亮氨酸、异亮氨酸生成物辅酶/辅基激活剂抑制剂GSSG、H2OGSH NADP+6-磷酸葡萄糖、ADP Mg2+6-磷酸果糖6-磷酸葡萄糖、ADP Mg2+6-磷酸果糖6-磷酸果糖Mg2+1,6-二磷酸果糖Mg2+AMP、ADP、F-6-P、F柠檬酸、ATP磷酸二羟丙酮、3-磷酸甘油醛3-磷酸甘油醛1,3-二磷酸甘油酸NAD+3-磷酸甘油酸、ATP Mg2+2-磷酸甘油酸Mg2+磷酸烯醇式丙酮酸、H2O丙酮酸、ATP K+、Mg2+1,6-二磷酸果糖丙氨酸、高ATP水平乳酸NADH、H+丙酮酸NAD+2,6-二磷酸果糖、ADP6-磷酸果糖、Pi羟乙基TPP焦磷酸硫胺素(TPP)乙酰CoA、二氢硫辛酸二氢硫辛酸、辅酶A硫辛酸FAD(直接)、NAD+柠檬酸、CoASH ADP ATP、柠檬酸、NADH、琥珀酰CoA 异柠檬酸α-酮戊二酸、CO2NAD+ADP、Ca2+ATP琥珀酰CoA、CO2NAD+、硫辛酸、FAD、TPP乙酰CoA、琥珀酰CoA、NAD琥珀酸、CoASH、GTP延胡索酸FAD丙二酸苹果酸草酰乙酸NAD+6-磷酸葡萄糖内酯NADP+NADPH6-磷酸葡萄糖酸5-磷酸核酮糖、CO2NADP+5-磷酸核糖草酰乙酸、ADP+Pi生物素磷酸烯醇式丙酮酸、GDP、CO2天冬氨酸,α-酮戊二酸6-磷酸果糖、Pi葡萄糖、Pi1-磷酸葡萄糖UDPG、PPi糖原(+1)ATP、6-P-G糖原(分支)糖原(-1)AMP,Ca+ATP、6-P-G、葡萄糖糖原糖原(脱支)ALA、CO2、CoASH磷酸吡哆醛(维生素B6)血红素/高铁血红素Pb卟胆原(PBG)线状四吡咯、NH3尿卟啉原Ⅲ、NH3粪卟啉原Ⅲ、CO2原卟啉原Ⅸ原卟啉Ⅸ血红素Pb2,3-BPG(2,3-二磷酸甘油酸)3-磷酸甘油酸、PiQH2、NAD+FMN、Fe-S鱼藤酮、安密妥、粉蝶酶素QH2、FAD FAD、Fe-SCoQ、还原性细胞色素c血红素b-562、血红素b-566、血红素c1、Fe-S抗霉素A、二巯基丙醇细胞色素c、H2O血红素a、血红素a3、CuA和CuB CO、CN-、叠氮化物ATP ADP(主要),甲状腺素α-磷酸甘油NADH、H+磷酸二羟丙酮、QH2FAD、Fe-SH2O、O2H2O、ROH2O2、O22-单酰甘油、游离脂肪辅脂酶溶血磷脂、游离脂肪酸(FFA)胆固醇、游离脂肪酸(FFA)脂酰CoA、AMP、PPi三酰甘油、CoASH三酰甘油、游离脂肪酸(FFA)肾上腺素、胰高血糖胰岛素单酰甘油、游离脂肪酸(FFA)甘油、游离脂肪酸(FFA)脂酰CoA、AMP、PPiCoASH、脂酰肉碱脂酰肉碱(内)、肉碱(外)脂酰CoA、肉碱反式⊿2-烯脂酰CoA FADL(+)-β-羟脂酰CoAβ-酮脂酰CoA NAD+脂酰CoA(C n)、乙酰CoA琥珀酰CoA、ADP、Pi乙酰乙酰CoA、CoASHHMG-CoA乙酰乙酸、乙酰CoAβ-羟基丁酸NADH、H+乙酰乙酸NAD+乙酰乙酰CoA、琥珀酸乙酰乙酰CoA、AMP、PPi乙酰CoA3-磷酸甘油、ADP磷酸二羟丙酮NAD草酰乙酸、乙酰CoA、ADP、Pi丙酮酸丙二酰CoA、ADP、Pi生物素、Mn2+柠檬酸、异柠檬酸、长链脂酰CoA、胰高血糖素乙酰-酶复合物、CoASH乙酰-丙二酰-酶复合物、CoASHβ-酮脂酰~S-ACP、CO2β-羟基丁酰~S-ACPNADPH、H+Δ2-烯脂酰~S-ACP、H20丁酰~S-ACP NADPH、H+软脂酸、(β-酮脂酰合酶)软脂酸、CO2、H2O、AD NADPH、H+单不饱和脂肪酸磷脂酸、CoASH1,2-甘油二酯、Pi三酰甘油、CoASHCDP-磷酸乙醇胺、PPiCDP-磷酸胆碱、PPi脑磷脂、CMP卵磷脂、CMP心磷脂、CMP磷脂酰肌醇、CMP乙酰乙酰CoA、CoASHHMG-CoA甲羟戊酸、CoASH NADPH、H+胰岛素、甲状腺素、胰高血糖素异戊烯焦磷酸鲨烯(30C)胆固醇、CO2胆固醇酯胆固醇酯、溶血卵磷脂CM残粒\VLDL残粒甘油、FFA、溶血磷脂等ROH、H2O NADPH、H+醛、NH3、H2O2乙醛乙酸氨基化合物二氢偶氮化合物(裂解)(产物)(产物)、UDP(产物)、PAP(产物)、CoASH(产物)、CoASH(谷胱甘肽结合产物)(产物)、S-腺苷同型半胱氨酸7α-羟胆固醇NADPH、H+维生素C、甲状腺素胆绿素、CO、Fe3+NADPH、H+血红素胆红素NADPH、H+胆红素葡萄糖醛酸酯、UDP胆红素、(葡萄糖醛酸)PRPP、AMP ADP5-PRA、谷氨酸、PPi Mg2+ATP、PRPP AMP、ADP、别嘌呤醇、6-巯GAR、ATP、Pi Mg2+FGAR、FH4FGAM、谷氨酸、ADP、PiAIR、ADP、Pi Mg2+CAIR、ADP、Pi生物素SAICAR、ADP、PiAICAR、延胡索酸FAICAR、FH4IMP、H2O腺苷酸代琥珀酸、GDP、Pi GTP AMP、6-巯基嘌呤AMP、延胡索酸GTP AMPXMP NAD+ATP GMP、6-巯基嘌呤GMP、谷氨酸、ADP、Pi ATP GMPNTP\dNTPATP、PPiITP\UTP、Ppi6-巯基嘌呤AMP、ADP腺苷\鸟苷次黄苷次黄嘌呤\鸟嘌呤、5-磷酸核糖黄嘌呤、H2O2黄嘌呤、NH3尿酸、H2O2氨基甲酰磷酸、ADP、Pi、谷氨酸PRPP、ATP UMP氨基酰天冬氨酸、Pi ATP氨基酰天冬氨酸、CTP 二氢乳清酸、H2O乳清酸NAD+乳清酸核苷酸PRPPUMP、CO2CTP、谷氨酸、ADP、Pi嘧啶核苷酸、PpiUMP、ADP尿嘧啶、NH3β-丙氨酸、NH3、CO2N ADPH\NADH、H+NADPH\NADH、H+β-氨基异丁酸、NH3、CO2dNDP、H2O、氧化型硫氧还蛋白还原型硫氧还蛋白NADPH、H+γ-谷氨酰氨基酸、半胱氨酰甘氨酸氨基酸、5-氧脯氨酸谷氨酸、ADP、Pi甘氨酸、半胱氨酸γ-谷氨酰半胱氨酸、ADP、Pi谷胱甘肽、ADP、Pi泛素-泛素活化酶、AMP、Ppi泛素-泛素活化酶、泛素活化酶泛素-蛋白质α-酮戊二酸、丙氨酸磷酸吡哆醛(维生素B6)磷酸吡哆醛(维生素B6)α-酮戊二酸、天冬氨酸α-酮戊二酸、NH3NADPH\NADH、H+GDP、ADP GTP、ATP谷氨酰胺NH3、谷氨酸氨基甲酰磷酸、ADP、P Mg2+N-乙酰谷氨酸(AGA)瓜氨酸、Pi(磷酸形式)精氨酸代琥珀酸、H2O、AMP、PPi精氨酸、延胡索酸尿素、鸟氨酸胺类、CO2GABA、CO2牛磺酸、CO2组胺、CO25-羟色氨酸5-羟色胺、CO2腐胺、CO2脱羧基SAM、CO2亚精胺(精脒)、5'-甲基-S-腺苷精胺FH2磺胺类药物FH4氨甲蝶呤S-腺苷甲硫氨酸(SAM)、PPi、PiS-腺苷同型半胱氨酸、甲基化产物同型半胱氨酸、腺苷蛋氨酸、FH4鸟氨酸、胍乙酸肌酸、S-腺苷同型半胱氨酸磷酸肌酸、ADP肌酐、H2O肌酐、Pi酪氨酸、H2O、FH2苯丙酮酸多巴(3,4-二羟苯丙氨酸)多巴(3,4-二羟苯丙氨C u2+羟苯丙酮酸相应的脂酰CoA调节方式其他其他Ⅱ激素调节,变构调节关键酶Ⅰ、Ⅱ、Ⅲ广泛,同工酶,胰岛素,产物的反馈抑制激素调节,变构调节,共关键酶Ⅳ肝,胰岛素,同工酶激素调节关键酶胰岛素底物水平磷酸化底物水平磷酸化激素调节关键酶胰高血糖素使酶失活同工酶5种同工酶同工酶产物激活6-磷酸果糖激酶-2变构调节,化学修饰丙酮酸脱氢酶复合体、含维生素B1变构调节,化学修饰丙酮酸脱氢酶复合体、含硫辛酸、泛酸变构调节,化学修饰丙酮酸脱氢酶复合体、含维生素B2、PP、NADH、琥珀酰CoA关键酶柠檬酸-丙酮酸循环中间产物顺乌头酸、H2O关键酶第一次氧化脱羧变构调节,化学修饰关键酶第二次氧化脱羧底物水平磷酸化竞争性抑制反向进行可使草酰乙酸穿出线粒体膜反馈抑制关键酶主要受NADPH/NADP+比值调节不可逆不可逆包括磷酸戊糖异构酶和磷酸戊糖差向酶激素调节,反馈抑制关键酶线粒体激素调节,反馈抑制关键酶线粒体/胞液另:苹果酸/天冬氨酸穿梭(肝和心肌)激素调节,反馈抑制关键酶激素调节,反馈抑制关键酶反向进行可将1-P-G转化为6-P-G葡萄糖活化共价修饰,变构调节关键酶作用于α-1,4糖苷键,肾上腺素/胰高血糖素抑制作用于α-1,6糖苷键共价修饰,变构调节关键酶作用于α-1,4糖苷键,至距分支4个残基处,肾上腺素/胰高血糖素促进至距分支1个残基处作用于α-1,6糖苷键激素调节,反馈抑制限速酶ALA(δ-氨基-γ-酮戊酸),缺氧,雄激素和睾酮标志酶密妥、粉蝶酶素完全镶嵌在线粒体内膜中,有质子泵功能线粒体内膜基质侧,无质子泵功能完全镶嵌在线粒体内膜中,有质子泵功能完全镶嵌在线粒体内膜中,有质子泵功能受体调节(?)完全镶嵌在线粒体内膜中、解偶联剂:寡霉素神经组织和骨骼肌(胞质)神经组织和骨骼肌(线粒体),生成1.5分子ATP清除超氧阴离子(一种自由基)小肠小肠,中间产物是二酰甘油激素调节限速酶脂肪组织,组织脂肪酶不受激素影响脂肪组织脂肪组织内质网、线粒体外膜外限速酶线粒体外膜内线粒体内膜同工酶线粒体内膜内1.5ATP2.5ATP限速酶β-羟-β-甲戊二酸单酰CoA部分自发脱羧生成丙酮心、肾、脑及骨骼肌的线粒体肾、心和脑的线粒体心、肾、脑及骨骼肌线粒体可使游离甘油得到利用α-磷酸甘油穿梭有类似的反应合成脂肪酸,反向:柠檬酸合酶共价修饰,变构调节,激限速酶生物素起固定CO2和转移羧基的作用脂肪酸合成酶系⑴脂肪酸合成酶系⑵脂肪酸合成酶系⑶脂肪酸合成酶系⑷脂肪酸合成酶系⑹脂肪酸合成酶系⑸脂肪酸合成酶系⑺胞质中进行肝中进行肝、脂肪细胞肝、脂肪细胞肝、脂肪细胞β-羟-β-甲戊二酸单酰CoA激素调节,反馈抑制,共限速酶内质网5C(5C'+5C*2)*2→30C30C→27C+3CO2见于LDL受体途径见于HDL代谢外周组织外周组织酯酶、糖苷酶、酰胺酶等葡萄糖醛酸结合反应,存在于肝脏微粒体硫酸结合反应,3’-磷酸腺苷-5’-磷酰硫酸谷胱甘肽结合反应乙酰基结合反应甘氨酸结合反应甲基结合反应、S-腺苷半胱氨酸激素调节限速酶产物经一系列反应生成胆酸和鹅脱氧胆酸限速酶三种同工酶游离胆红素→结合胆红素(一酯或二酯)反馈抑制PRPP:5-磷酸核糖-1-焦磷酸反馈抑制、竞争性抑制限速酶谷氨酰胺核糖焦磷酸酰胺转移酶;5-PRA:5-磷酸核糖胺GAR:甘氨酰胺核苷酸FGAR:甲酰甘氨酰胺核苷酸FGAM:甲酰甘氨咪核苷酸AIR:5-氨基咪唑核苷酸CAIR:5-氨基咪唑4-羧酸核苷酸SAICAR:5-氨基咪唑4-(N-琥珀基)甲酰胺核苷酸AICAR:5-氨基咪唑4-氨甲酰核苷酸FAICAR:5-甲酰氨基咪唑4-氨甲酰核苷酸反馈抑制、竞争性抑制反馈抑制反馈抑制、竞争性抑制XMP:黄嘌呤核苷酸反馈抑制竞争性抑制R-5-P:汤变构调节反馈抑制限速酶变构调节对胞嘧啶不起作用N代表A、G、U、C等碱基关键酶活化传递识别,与赖氨酸-ε氨基形成“异肽键”又名谷丙转氨酶(GPT)又名谷草转氨酶(GOT)变构调节反应可逆,可与转氨酶联合参与联合脱氨基存在于脑、肌肉存在于肝、肾变构调节关键酶存在于线粒体限速酶GABA(γ-氨基丁酸)是重要的抑制型神经递质L-半胱氨酸氧化成磺酸丙氨酸。
MRS-2578-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Oct.-05-2018Print Date:Oct.-05-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :MRS 2578Catalog No. :HY-13104CAS No. :711019-86-21.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4),H302Acute aquatic toxicity (Category 1),H400Chronic aquatic toxicity (Category 1),H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effects.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor ⁄ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents ⁄ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:MRS-2578;MRS2578Formula:C20H20N6S4Molecular Weight:472.67CAS No. :711019-86-24. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077Class: 9Packing group: IIIEMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutant.IATAUN number: 3077Class: 9Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Semaglutide-TFA-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Feb.-01-2019Print Date:Feb.-01-20191. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Semaglutide (TFA)Catalog No. :HY-114118ACAS No. :None1.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:N/AMolecular Weight:N/ACAS No. :None4. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-80°C 2 years-20°C 1 yearIn solvent-80°C 6 months-20°C 1 month7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2019 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
GNF-5837-SDS-MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Oct.-03-2018Print Date:Oct.-03-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :GNF-5837Catalog No. :HY-13491CAS No. :1033769-28-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4),H302Acute aquatic toxicity (Category 1),H400Chronic aquatic toxicity (Category 1),H4102.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H410 Very toxic to aquatic life with long lasting effects.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor ⁄ physician if you feel unwell.P330 Rinse mouth.P391 Collect spillage.P501 Dispose of contents ⁄ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:GNF5837;GNF 5837Formula:C28H21F4N5O2Molecular Weight:535.49CAS No. :1033769-28-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance Orange to red (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGUN number: 3077Class: 9Packing group: IIIEMS-No: F-A, S-FProper shipping name: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.Marine pollutant: Marine pollutant.IATAUN number: 3077Class: 9Packing group: IIIProper shipping name: Environmentally hazardous substance, solid, n.o.s.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2018 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
Metiamide_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :MetiamideCatalog No. :HY-15540CAS No. :34839-70-81.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:NoneFormula:C9H16N4S2Molecular Weight:244.38CAS No. :34839-70-84. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
苏州格锐思生物科技有限公司丙二醛(MDA)含量测试盒说明书
丙二醛(malondialdehyde,MDA)含量测试盒说明书(货号:G0109F分光法48样)一、产品简介:丙二醛(MDA)是由于生物体官衰老或在逆境条件下受伤害,其组织或器官膜脂质发生过氧化反应而产生的。
它的含量与生物体衰老及逆境伤害有密切关系。
MDA在高温、酸性条件下,与硫代巴比妥酸(thiobarbituric acid,TBA)缩合,生成红色产物,在532nm有最大吸收峰,进行比色后可估测样品中过氧化脂质的含量;同时测定600nm下的吸光度,利用532nm与600nm下的吸光度的差值计算MDA的含量。
二、试剂盒的组分与配制试剂名称规格保存要求备注提取液液体60mL×1瓶4℃保存工作液液体30mL×1瓶4℃避光保存若有沉淀析出,可50℃水浴10min,溶解备用三、所需的仪器和用品:可见分光光度计、1mL玻璃比色皿(光径1cm)、水浴锅、台式离心机、可调式移液器、研钵、冰和蒸馏水。
四、丙二醛(MDA)的测定:建议正式实验前选取2个样本做预测定,了解本批样品情况,熟悉实验流程,避免实验样本和试剂浪费!1、样本制备:①组织样本:称取约0.1g组织(水分充足的样本可取0.5g),加入1mL提取液,进行冰浴匀浆。
4℃×12000rpm离心10min,取上清,置冰上待测。
【注】:若增加样本量,可按照组织质量(g):提取液体积(mL)为1:5~10的比例进行提取。
②细菌/细胞样本:先收集细菌或细胞到离心管内,离心后弃上清;取500万细菌或细胞加入1mL提取液,在4ºC或冰浴进行匀浆(或使用各类常见电动匀浆器)。
4ºC约12,000rpm离心10min,取上清作为待测样品。
【注】:若增加样本量,可按照细菌/细胞数量(104):提取液(mL)为500~1000:1的比例进行提取。
③液体样本:直接检测。
若浑浊,离心后取上清检测。
2、上机检测①打开分光光度计预热30min,蒸馏水调零,同时水浴锅加热到90-95℃。
Erythrosin_B_SDS_MedChemExpress
Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:Jan.-22-2018Print Date:Jan.-22-20181. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Erythrosin BCatalog No. :HY-D0259CAS No. :16423-68-01.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acute toxicity, Oral (Category 4), H302Chronic aquatic toxicity (Category 4), H4132.2 GHS Label elements, including precautionary statementsPictogramSignal word WarningHazard statement(s)H302 Harmful if swallowed.H413 May cause long lasting harmful effects to aquatic life.Precautionary statement(s)P264 Wash skin thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P273 Avoid release to the environment.P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER ⁄doctor if you feel unwell.Rinse mouth.P501 Dispose of contents ⁄ container to an approved waste disposal plant.H413 May cause long lasting harmful effects to aquatic life.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:Erythrosin extra bluishFormula:C20H6I4Na2O5Molecular Weight:879.86CAS No. :16423-68-04. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance Pink to red (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。
一种含有阿戈美拉汀的分散片及其制备方法[发明专利]
专利名称:一种含有阿戈美拉汀的分散片及其制备方法专利类型:发明专利
发明人:王寅洁,马莉
申请号:CN201610845349.4
申请日:20160924
公开号:CN106333929A
公开日:
20170118
专利内容由知识产权出版社提供
摘要:本发明公开了一种含有阿戈美拉汀的分散片的制备方法。
该分散片含有阿戈美拉汀以及其它药学上可接受的辅料,采用湿法制粒技术进行制备,通过调整功能性辅料的用量及加入方式,达到降低溶出速度与原研制剂一致的目的,提高生物等效的概率。
申请人:万特制药(海南)有限公司
地址:570314 海南省海口市秀英区南海大道279号
国籍:CN
更多信息请下载全文后查看。
质谱 胰酶 sds溶解
质谱胰酶 sds溶解
质谱(Mass Spectrometry)是一种分析化学技术,用于确定化合物的分子质量和结构。
它基于对化合物分子进行离子化,并对离子进行质量分析的原理。
质谱技术在许多领域中得到广泛应用,包括生物化学、药物研发、环境科学等。
胰酶(Pancreatic enzymes)是由胰腺分泌的消化酶,主要用于分解食物中的蛋白质、碳水化合物和脂肪,以促进食物的消化和吸收。
胰酶包括胰蛋白酶、胰淀粉酶和胰脂酶等。
SDS(Sodium Dodecyl Sulfate)是一种常用的表面活性剂,常用于蛋白质电泳实验中的蛋白质样品预处理。
SDS可以使蛋白质在电泳过程中带有负电荷,使其按照分子质量大小进行分离。
通常,将蛋白质样品与SDS混合,并加热至变性,使蛋白质完全展开,然后进行电泳分离。
对于SDS的溶解,可以将一定量的SDS加入适量的缓冲溶液中,并进行充分搅拌,直到SDS完全溶解。
溶解后的SDS溶液可以用于蛋白质样品的预处理和电泳实验。
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Inhibitors, Agonists, Screening LibrariesSafety Data Sheet Revision Date:May-24-2017Print Date:May-24-20171. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :MetrifonateCatalog No. :HY-B1220CAS No. :52-68-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228-6898Fax:609-228-5909E-mail:sales@1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureNot a hazardous substance or mixture.2.2 GHS Label elements, including precautionary statementsNot a hazardous substance or mixture.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:TrichlorfonFormula:C4H8Cl3O4PMolecular Weight:257.44CAS No. :52-68-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical attention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritant fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate ventilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder-20°C 3 years4°C 2 yearsIn solvent-80°C 6 months-20°C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occupational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance White to off-white (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data availableBoiling point/range No data availableFlash point No data availableEvaporation rate No data availableFlammability (solid, gas)No data availableUpper/lower flammability or explosive limits No data availableVapor pressure No data availableVapor density No data availableRelative density No data availableWater Solubility No data availablePartition coefficient No data availableAuto-ignition temperature No data availableDecomposition temperature No data availableViscosity No data availableExplosive properties No data availableOxidizing properties No data available9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibility of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present at a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available data. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based on available data. For more details, see section 212. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment unavailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)This substance is considered to be non-hazardous for transport.IMDGThis substance is considered to be non-hazardous for transport.IATAThis substance is considered to be non-hazardous for transport.15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.SARA 311/312 Hazards:No SARA Hazards.Massachusetts Right To Know Components:No components are subject to the Massachusetts Right to Know Act.Pennsylvania Right To Know Components:No components are subject to the Pennsylvania Right to Know Act.New Jersey Right To Know Components:No components are subject to the New Jersey Right to Know Act.California Prop. 65 Components:This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm.16. OTHER INFORMATIONCopyright 2017 MedChemExpress. The above information is correct to the best of our present knowledge but does not purport to be all inclusive and should be used only as a guide. The product is for research use only and for experienced personnel. It must only be handled by suitably qualified experienced scientists in appropriately equipped and authorized facilities. The burden of safe use of this material rests entirely with the user. MedChemExpress disclaims all liability for any damage resulting from handling or from contact with this product.Caution: Product has not been fully validated for medical applications. For research use only.Tel: 609-228-6898 Fax: 609-228-5909 E-mail: tech@Address: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA。