Impurity and correlation effects on transport in one-dimensional quantum wires

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ASTM_B117-2007 盐雾试验规程

ASTM_B117-2007  盐雾试验规程

Designation:B117–07Standard Practice forOperating Salt Spray(Fog)Apparatus1This standard is issued under thefixed designation B117;the number immediately following the designation indicates the year of original adoption or,in the case of revision,the year of last revision.A number in parentheses indicates the year of last reapproval.A superscript epsilon(e)indicates an editorial change since the last revision or reapproval.This standard has been approved for use by agencies of the Department of Defense.1.Scope1.1This practice covers the apparatus,procedure,and conditions required to create and maintain the salt spray(fog) test environment.Suitable apparatus which may be used is described in Appendix X1.1.2This practice does not prescribe the type of test speci-men or exposure periods to be used for a specific product,nor the interpretation to be given to the results.1.3The values stated in SI units are to be regarded as the standard.The values given in parentheses are for information only.1.4This standard does not purport to address all of the safety concerns,if any,associated with its use.It is the responsibility of the user of this standard to establish appro-priate safety and health practices and determine the applica-bility of regulatory limitations prior to use.2.Referenced Documents2.1ASTM Standards:2B368Test Method for Copper-Accelerated Acetic Acid-Salt Spray(Fog)Testing(CASS Test)D609Practice for Preparation of Cold-Rolled Steel Panels for Testing Paint,Varnish,Conversion Coatings,and Related Coating ProductsD1193Specification for Reagent WaterD1654Test Method for Evaluation of Painted or Coated Specimens Subjected to Corrosive EnvironmentsE70Test Method for pH of Aqueous Solutions With the Glass ElectrodeE691Practice for Conducting an Interlaboratory Study to Determine the Precision of a Test MethodG85Practice for Modified Salt Spray(Fog)Testing3.Significance and Use3.1This practice provides a controlled corrosive environ-ment which has been utilized to produce relative corrosion resistance information for specimens of metals and coated metals exposed in a given test chamber.3.2Prediction of performance in natural environments has seldom been correlated with salt spray results when used as stand alone data.3.2.1Correlation and extrapolation of corrosion perfor-mance based on exposure to the test environment provided by this practice are not always predictable.3.2.2Correlation and extrapolation should be considered only in cases where appropriate corroborating long-term atmo-spheric exposures have been conducted.3.3The reproducibility of results in the salt spray exposure is highly dependent on the type of specimens tested and the evaluation criteria selected,as well as the control of the operating variables.In any testing program,sufficient repli-cates should be included to establish the variability of the results.Variability has been observed when similar specimens are tested in different fog chambers even though the testing conditions are nominally similar and within the ranges speci-fied in this practice.4.Apparatus4.1The apparatus required for salt spray(fog)exposure consists of a fog chamber,a salt solution reservoir,a supply of suitably conditioned compressed air,one or more atomizing nozzles,specimen supports,provision for heating the chamber, and necessary means of control.The size and detailed con-struction of the apparatus are optional,provided the conditions obtained meet the requirements of this practice.4.2Drops of solution which accumulate on the ceiling or cover of the chamber shall not be permitted to fall on the specimens being exposed.1This practice is under the jurisdiction of ASTM Committee G01on Corrosionof Metals and is the direct responsibility of Subcommittee G01.05on LaboratoryCorrosion Tests.Current edition approved March1,2007.Published March2007.Originallyapproved st previous edition approved in2003as B117–03.2For referenced ASTM standards,visit the ASTM website,,orcontact ASTM Customer Service at service@.For Annual Book of ASTMStandards volume information,refer to the standard’s Document Summary page onthe ASTM website.Copyright©ASTM International,100Barr Harbor Drive,PO Box C700,West Conshohocken,PA19428-2959,United States.4.3Drops of solution which fall from the specimens shall not be returned to the solution reservoir for respraying.4.4Material of construction shall be such that it will not affect the corrosiveness of the fog.4.5All water used for this practice shall conform to Type IV water in Specification D1193(except that for this practice limits for chlorides and sodium may be ignored).This does not apply to running tap water.All other water will be referred to as reagent grade.5.Test Specimens5.1The type and number of test specimens to be used,as well as the criteria for the evaluation of the test results,shall be defined in the specifications covering the material or product being exposed or shall be mutually agreed upon between the purchaser and the seller.6.Preparation of Test Specimens6.1Specimens shall be suitably cleaned.The cleaning method shall be optional depending on the nature of the surface and the contaminants.Care shall be taken that specimens are not recontaminated after cleaning by excessive or careless handling.6.2Specimens for the evaluation of paints and other organic coatings shall be prepared in accordance with applicable specification(s)for the material(s)being exposed,or as agreed upon between the purchaser and the supplier.Otherwise,the test specimens shall consist of steel meeting the requirements of Practice D609and shall be cleaned and prepared for coating in accordance with the applicable procedure of Practice D609.6.3Specimens coated with paints or nonmetallic coatings shall not be cleaned or handled excessively prior to test.6.4Whenever it is desired to determine the development of corrosion from an abraded area in the paint or organic coating, a scratch or scribed line shall be made through the coating with a sharp instrument so as to expose the underlying metal before testing.The conditions of making the scratch shall be as defined in Test Method D1654,unless otherwise agreed upon between the purchaser and the seller.6.5Unless otherwise specified,the cut edges of plated, coated,or duplex materials and areas containing identification marks or in contact with the racks or supports shall be protected with a suitable coating stable under the conditions of the practice.N OTE1—Should it be desirable to cut test specimens from parts or from preplated,painted,or otherwise coated steel sheet,the cut edges shall be protected by coating them with paint,wax,tape,or other effective media so that the development of a galvanic effect between such edges and the adjacent plated or otherwise coated metal surfaces,is prevented.7.Position of Specimens During Exposure7.1The position of the specimens in the salt spray chamber during the test shall be such that the following conditions are met:7.1.1Unless otherwise specified,the specimens shall be supported or suspended between15and30°from the vertical and preferably parallel to the principal direction offlow of fog through the chamber,based upon the dominant surface being tested.7.1.2The specimens shall not contact each other or any metallic material or any material capable of acting as a wick.7.1.3Each specimen shall be placed to permit unencum-bered exposure to the fog.7.1.4Salt solution from one specimen shall not drip on any other specimen.N OTE2—Suitable materials for the construction or coating of racks and supports are glass,rubber,plastic,or suitably coated wood.Bare metal shall not be used.Specimens shall preferably be supported from the bottom or the side.Slotted wooden strips are suitable for the support offlat panels.Suspension from glass hooks or waxed string may be used as long as the specified position of the specimens is obtained,if necessary by means of secondary support at the bottom of the specimens.8.Salt Solution8.1The salt solution shall be prepared by dissolving561 parts by mass of sodium chloride in95parts of water conforming to Type IV water in Specification D1193(except that for this practice limits for chlorides and sodium may be ignored).Careful attention should be given to the chemical content of the salt.The salt used shall be sodium chloride with not more than0.3%by mass of total impurities.Halides (Bromide,Fluoride,and Iodide)other than Chloride shall constitute less than0.1%by mass of the salt content.Copper content shall be less than0.3ppm by mass.Sodium chloride containing anti-caking agents shall not be used because such agents may act as corrosion inhibitors.See Table1for a listing of these impurity restrictions.Upon agreement between the purchaser and the seller,analysis may be required and limits TABLE1Maximum Allowable Limits for Impurity Levels inSodium Chloride A,B,CImpurity Description Allowable Amount Total Impurities#0.3% Halides(Bromide,Fluoride and Iodide)excluding Chloride<0.1% Copper<0.3ppmAnti-caking Agents noneA A common formula used to calculate the amount of salt required by mass to achieve a5%salt solution of a known mass of water is:0.0533Mass of Water5Mass of NaCl requiredThe mass of water is1g per1mL.To calculate the mass of salt required in grams to mix1L of a5%salt solution,multiply0.053by1000g(35.27oz,the mass of1L of water).This formula yields a result of53g(1.87oz)of NaCl required for each liter of water to achieve a5%salt solution by mass.The0.053multiplier for the sodium chloride used above is derived by the following:1000g~mass of a full L of water!divided by0.95~water is only95%of the total mixture by mass!yields1053gThis1053g is the total mass of the mixture of one L of water with a5%sodium chloride concentration.1053g minus the original weight of the L of water,1000g, yields53g for the weight of the sodium chloride.53g of total sodium chloride divided by the original1000g of water yields a0.053multiplier for the sodium chloride.As an example:to mix the equivalent of200L(52.83gal)of5%sodium chloride solution,mix10.6kg(23.37lb)of sodium chloride into200L(52.83gal)of water. 200L of water weighs200000g.200000g of water30.053(sodium chloride multiplier)=10600g of sodium chloride,or10.6kg.B In order to ensure that the proper salt concentration was achieved when mixing the solution,it is recommended that the solution be checked with either a salimeter hydrometer or specific gravity hydrometer.When using a salimeter hydrometer,the measurement should be between4and6%at25°C(77°F).When using a specific gravity hydrometer,the measurement should be between1.0255and1.0400at 25°C(77°F).C If the purity of the salt used is>99.9%,then the limits for halides can be ignored.This is due to the fact that the halides cannot be$0.1%with a salt purity of>99.9%.If the salt used is of lower purity,then test forhalides. --````````,`,,,`,``,`,`,`````-`-`,,`,,`,`,,`---established for elements or compounds not specified in the chemical composition given above.8.2The pH of the salt solution shall be such that when atomized at 35°C (95°F)the collected solution will be in the pH range from 6.5to 7.2(Note 3).Before the solution is atomized it shall be free of suspended solids (Note 4).The pH measurement shall be made at 25°C (77°F)using a suitable glass pH-sensing electrode,reference electrode,and pH meter system in accordance with Test Method E 70.N OTE 3—Temperature affects the pH of a salt solution prepared from water saturated with carbon dioxide at room temperature and pH adjust-ment may be made by the following three methods:(1)When the pH of a salt solution is adjusted at room temperature,and atomized at 35°C (95°F),the pH of the collected solution will be higher than the original solution due to the loss of carbon dioxide at the higher temperature.When the pH of the salt solution is adjusted at room temperature,it is therefore necessary to adjust it below 6.5so the collected solution after atomizing at 35°C (95°F)will meet the pH limits of 6.5to 7.2.Take about a 50-mL sample of the salt solution as prepared at room temperature,boil gently for 30s,cool,and determine the pH.When the pH of the salt solution is adjusted to 6.5to 7.2by this procedure,the pH of the atomized and collected solution at 35°C (95°F)will come within this range.(2)Heating the salt solution to boiling and cooling to 35°C (95°F)and maintaining it at 35°C (95°F)for approximately 48h before adjusting the pH produces a solution the pH of which does not materially change when atomized at 35°C (95°F).(3)Heating the water from which the salt solution is prepared to 35°C (95°F)or above,to expel carbon dioxide,and adjusting the pH of the salt solution within the limits of 6.5to 7.2produces a solution the pH of which does not materially change when atomized at 35°C (95°F).N OTE 4—The freshly prepared salt solution may be filtered or decanted before it is placed in the reservoir,or the end of the tube leading from the solution to the atomizer may be covered with a double layer of cheesecloth to prevent plugging of the nozzle.N OTE 5—The pH can be adjusted by additions of dilute ACS reagent grade hydrochloric acid or sodium hydroxide solutions.9.Air Supply9.1The compressed air supply to the Air Saturator Tower shall be free of grease,oil,and dirt before use by passing through well-maintained filters.(Note 6)This air should be maintained at a sufficient pressure at the base of the Air Saturator Tower to meet the suggested pressures of Table 2at the top of the Air Saturator Tower.N OTE 6—The air supply may be freed from oil and dirt by passing it through a suitable oil/water extractor (that is commercially available)to stop any oil from reaching the Air Saturator Tower.Many oil/water extractors have an expiration indicator,proper preventive maintenance intervals should take these into account.9.2The compressed air supply to the atomizer nozzle or nozzles shall be conditioned by introducing it into the bottomof a tower fillwed with water.A common method of introduc-ing the air is through an air dispersion device (X1.4.1).The level of the water must be maintained automatically to ensure adequate humidification.It is common practice to maintain the temperature in this tower between 46and 49°C (114–121°F)to offset the cooling effect of expansion to atmospheric pressure during the atomization process.Table 2shows the temperature,at different pressures,that are commonly used to offset the cooling effect of expansion to atmospheric pressure.9.3Careful attention should be given to the relationship of tower temperature to pressure since this relationship can have a direct impact to maintaining proper collection rates (Note 7).It is preferable to saturate the air at temperatures well above the chamber temperature as insurance of a wet fog as listed in Table 2.N OTE 7—If the tower is run outside of these suggested temperature and pressure ranges to acheive proper collection rates as described in 10.2of this practice,other means of verifying the proper corrosion rate in the chamber should be investigated,such as the use of control specimens (panels of known performance in the test conducted).It is preferred that control panels be provided that bracket the expected test specimen performance.The controls allow for the normalization of test conditions during repeated running of the test and will also allow comparisons of test results from different repeats of the same test.(Refer to Appendix X3,Evaluation of Corrosive Conditions,for mass loss procedures).10.Conditions in the Salt Spray Chamber10.1Temperature —The exposure zone of the salt spray chamber shall be maintained at 3562°C (9563°F).Each set point and its tolerance represents an operational control point for equilibrium conditions at a single location in the cabinet which may not necessarily represent the uniformity of condi-tions throughout the cabinet.The temperature within the exposure zone of the closed cabinet shall be recorded (Note 8)at least once daily (except on Saturdays,Sundays,and holidays when the salt spray test is not interrupted for exposing,rearranging,or removing test specimens or to check and replenish the solution in the reservoir)N OTE 8—A suitable method to record the temperature is by a continu-ous recording device or by a thermometer which can be read from outside the closed cabinet.The recorded temperature must be obtained with the salt spray chamber closed to avoid a false low reading because of wet-bulb effect when the chamber is open.10.2Atomization and Quantity of Fog —Place at least two clean fog collectors per atomizer tower within the exposure zone so that no drops of solution will be collected from the test specimens or any other source.Position the collectors in the proximity of the test specimens,one nearest to any nozzle and the other farthest from all nozzles.A typical arrangement is shown in Fig.1.The fog shall be such that for each 80cm 2(12.4in.2)of horizontal collecting area,there will be collected from 1.0to 2.0mL of solution per hour based on an average run of at least 16h (Note 9).The sodium chloride concentration of the collected solution shall be 561mass %(Notes 9-11).The pH of the collected solution shall be 6.5to 7.2.The pH measurement shall be made as described in 8.2(Note 3).N OTE 9—Suitable collecting devices are glass or plastic funnels withTABLE 2Suggested Temperature and Pressure guideline for the top of the Air Saturator Tower for the operation of a test at 35°C(95°F)Air Pressure,kPaTemperature,°CAir Pressure,PSITemperature,°F83461211496471411711048161191244918121--````````,`,,,`,``,`,`,`````-`-`,,`,,`,`,,`---the stems inserted through stoppers into graduated cylinders,or crystal-lizing dishes.Funnels and dishes with a diameter of 10cm (3.94in.)have an area of about 80cm 2(12.4in.2).N OTE 10—A solution having a specific gravity of 1.0255to 1.0400at 25°C (77°F)will meet the concentration requirement.The sodium chloride concentration may also be determined using a suitable salinity meter (for example,utilizing a sodium ion-selective glass electrode)or colorimetrically as follows.Dilute 5mL of the collected solution to 100mL with distilled water and mix thoroughly;pipet a 10-mL aliquot into an evaporating dish or casserole;add 40mL of distilled water and 1mL of 1%potassium chromate solution (chloride-free)and titrate with 0.1N silver nitrate solution to the first appearance of a permanent red coloration.A solution that requires between 3.4and 5.1mL of 0.1N silver nitrate solution will meet the concentration requirements.N OTE 11—Salt solutions from 2to 6%will give the same results,though for uniformity the limits are set at 4to 6%.10.3The nozzle or nozzles shall be so directed or baffled that none of the spray can impinge directly on the test specimens.11.Continuity of Exposure11.1Unless otherwise specified in the specifications cover-ing the material or product being tested,the test shall be continuous for the duration of the entire test period.Continu-ous operation implies that the chamber be closed and the spray operating continuously except for the short daily interruptions necessary to inspect,rearrange,or remove test specimens,to check and replenish the solution in the reservoir,and to make necessary recordings as described in Section 10.Operations shall be so scheduled that these interruptions are held to a minimum.12.Period of Exposure12.1The period of exposure shall be as designated by the specifications covering the material or product being tested or as mutually agreed upon between the purchaser and the seller.N OTE 12—Recommended exposure periods are to be as agreed upon between the purchaser and the seller,but exposure periods of multiples of 24h are suggested.13.Cleaning of Tested Specimens13.1Unless otherwise specified in the specifications cover-ing the material or product being tested,specimens shall be treated as follows at the end of the test:13.1.1The specimens shall be carefully removed.13.2Specimens may be gently washed or dipped in clean running water not warmer than 38°C (100°F)to remove salt deposits from their surface,and then immediately dried.14.Evaluation of Results14.1A careful and immediate examination shall be made as required by the specifications covering the material or product being tested or by agreement between the purchaser and the seller.15.Records and Reports15.1The following information shall be recorded,unless otherwise prescribed in the specifications covering the material or product being tested:15.1.1Type of salt and water used in preparing the salt solution,15.1.2All readings of temperature within the exposure zone of the chamber,15.1.3Daily records of data obtained from each fog-collecting device including the following:15.1.3.1V olume of salt solution collected in millilitres per hour per 80cm 2(12.4in.2),15.1.3.2Concentration or specific gravity at 35°C (95°F)of solution collected,and15.1.3.3pH of collectedsolution.N OTE —This figure shows a typical fog collector arrangement for a single atomizer tower cabinet.The same fog collector arrangement is also applicable for multiple atomizer tower and horizontal (“T”type)atomizer tower cabinet constructions as well.FIG.1Arrangement of FogCollectors--````````,`,,,`,``,`,`,`````-`-`,,`,,`,`,,`---15.2Type of specimen and its dimensions,or number or description of part,15.3Method of cleaning specimens before and after testing, 15.4Method of supporting or suspending article in the salt spray chamber,15.5Description of protection used as required in6.5, 15.6Exposure period,15.7Interruptions in exposure,cause,and length of time, and15.8Results of all inspections.N OTE13—If any of the atomized salt solution which has not contacted the test specimens is returned to the reservoir,it is advisable to record the concentration or specific gravity of this solution also.16.Keywords16.1controlled corrosive environment;corrosive condi-tions;determining mass loss;salt spray(fog)exposureAPPENDIXES(Nonmandatory Information)X1.CONSTRUCTION OF APPARATUSX1.1CabinetsX1.1.1Standard salt spray cabinets are available fromseveral suppliers,but certain pertinent accessories are requiredbefore they will function according to this practice and provideconsistent control for duplication of results.X1.1.2The salt spray cabinet consists of the basic chamber,an air-saturator tower,a salt solution reservoir,atomizingnozzles,specimen supports,provisions for heating the cham-ber,and suitable controls for maintaining the desired tempera-ture.X1.1.3Accessories such as a suitable adjustable baffle orcentral fog tower,automatic level control for the salt reservoir,and automatic level control for the air-saturator tower arepertinent parts of the apparatus.X1.1.4The size and shape of the cabinet shall be such thatthe atomization and quantity of collected solution is within the limits of this practice.X1.1.5The chamber shall be made of suitably inert mate-rials such as plastic,glass,or stone,or constructed of metal and lined with impervious plastics,rubber,or epoxy-type materials or equivalent.X1.1.6All piping that contacts the salt solution or spray should be of inert materials such as plastic.Vent piping should be of sufficient size so that a minimum of back pressure exists and should be installed so that no solution is trapped.The exposed end of the vent pipe should be shielded from extreme air currents that may causefluctuation of pressure or vacuum in the cabinet.X1.2Temperature ControlX1.2.1The maintenance of temperature within the salt chamber can be accomplished by several methods.It is generally desirable to control the temperature of the surround-ings of the salt spray chamber and to maintain it as stable as possible.This may be accomplished by placing the apparatus in a constant-temperature room,but may also be achieved by surrounding the basic chamber of a jacket containing water or air at a controlled temperature.X1.2.2The use of immersion heaters in an internal salt solution reservoir or within the chamber is detrimental where heat losses are appreciable because of solution evaporation and radiant heat on the specimens.X1.3Spray NozzlesX1.3.1Satisfactory nozzles may be made of hard rubber, plastic,or other inert materials.The most commonly used type is made of plastic.Nozzles calibrated for air consumption and solution-atomized are available.The operating characteristics of a typical nozzle are given in Table X1.1.X1.3.2It can readily be seen that air consumption is relatively stable at the pressures normally used,but a marked reduction in solution sprayed occurs if the level of the solution is allowed to drop appreciably during the test.Thus,the level of the solution in the salt reservoir must be maintained automatically to ensure uniform fog delivery during the test.3 X1.3.3If the nozzle selected does not atomize the salt solution into uniform droplets,it will be necessary to direct the spray at a baffle or wall to pick up the larger drops and prevent them from impinging on the test specimens.Pending a com-plete understanding of air-pressure effects,and so forth,it is important that the nozzle selected shall produce the desired 3A suitable device for maintaining the level of liquid in either the saturator tower or reservoir of test solution may be designed by a local engineering group,or it may be purchased from manufacturers of test cabinets as an accessory.TABLE X1.1Operating Characteristics of Typical Spray Nozzle SiphonHeight,cmAir Flow,dm3/min Solution Consumption,cm3/hAir Pressure,kPa Air Pressure,kPa34691031383469103138 101926.531.5362100384045845256 201926.531.536636276037204320 301926.531.5360138030003710 401926.631.536078021242904SiphonHeight,in.Air Flow,L/minSolutionConsumption,mL/hAir Pressure,psi Air Pressure,psi51015205101520 41926.531.5362100384045845256 81926.531.536636276037204320 121926.531.5360138030003710 161926.631.536078021242904 --````````,`,,,`,``,`,`,`````-`-`,,`,,`,`,,`---condition when operated at the air pressure selected.Nozzles are not necessarily located at one end,but may be placed in the center and can also be directed vertically up through a suitable tower.X1.4Air for AtomizationX1.4.1The air used for atomization must be free of grease, oil,and dirt before use by passing through well-maintainedfilters.Room air may be compressed,heated,humidified,and washed in a water-sealed rotary pump if the temperature of the water is suitably controlled.Otherwise cleaned air may be introduced into the bottom of a towerfilled with water through a porous stone or multiple nozzles.The level of the water must be maintained automatically to ensure adequate humidification.A chamber operated in accordance with this method and Appendix X1will have a relative humidity between95and 98%.Since salt solutions from2to6%will give the same results(though for uniformity the limits are set at4to6%),it is preferable to saturate the air at temperatures well above the chamber temperature as insurance of a wet fog.Table X1.2 shows the temperatures,at different pressures,that are required to offset the cooling effect of expansion to atmospheric pressure.X1.4.2Experience has shown that most uniform spray chamber atmospheres are obtained by increasing the atomizing air temperature sufficiently to offset heat losses,except those that can be replaced otherwise at very low-temperature gradi-ents.X1.5Types of ConstructionX1.5.1A modern laboratory cabinet is shown in Fig.X1.1. Walk-in chambers are usually constructed with a sloping ceiling.Suitably located and directed spray nozzles avoid ceiling accumulation and drip.Nozzles may be located at the ceiling,or0.91m(3ft)from thefloor directed upward at30to 60°over a passageway.The number of nozzles depends on type and capacity and is related to the area of the test space.An11 to19L(3to5-gal)reservoir is required within the chamber, with the level controlled.The major features of a walk-in type cabinet,which differs significantly from the laboratory type, are illustrated in Fig.X1.2.Construction of a plastic nozzle, such as is furnished by several suppliers,is shown in Fig.X1.3.TABLE X1.2Temperature and Pressure Requirements forOperation of Test at95°FAir Pressure,kPa8396110124 Temperature,°C46474849Air Pressure,psi12141618 Temperature,°F114117119121 --````````,`,,,`,``,`,`,`````-`-`,,`,,`,`,,`---。

219316024_鲜活虹鳟鱼的呼吸频率与肌肉品质的相关性

219316024_鲜活虹鳟鱼的呼吸频率与肌肉品质的相关性

吴艺文,赵曼曼,尤孝鹏,等. 鲜活虹鳟鱼的呼吸频率与肌肉品质的相关性[J]. 食品工业科技,2023,44(12):29−36. doi:10.13386/j.issn1002-0306.2022080201WU Yiwen, ZHAO Manman, YOU Xiaopeng, et al. Correlation between Respiratory Rate and Muscle Quality of Fresh Rainbow Trout (Oncorhynchus mykiss )[J]. Science and Technology of Food Industry, 2023, 44(12): 29−36. (in Chinese with English abstract). doi:10.13386/j.issn1002-0306.2022080201· 研究与探讨 ·鲜活虹鳟鱼的呼吸频率与肌肉品质的相关性吴艺文1,2,赵曼曼1,2,尤孝鹏1,2,汪 兰2,石 柳2,丁安子2,吴文锦2,陈 胜2,孙卫青1, *,熊光权2,*(1.长江大学生命科学学院,湖北荆州 434025;2.湖北省农业科学院农产品加工与核农技术研究所,农业农村部农产品冷链物流技术重点实验室,湖北武汉 430064)摘 要:为探讨鲜活虹鳟鱼的呼吸频率与肌肉品质之间的相关性,研究了不同呼吸频率所对应的肌肉品质的变化。

测定了乳酸、糖原、丙二醛(Malondialdehyde ,MDA )以及核苷酸类化合物含量和加压失水率。

结果表明,随着呼吸频率的上升,糖原含量下降、丙二醛和核苷酸类化合物含量、加压失水率上升。

当呼吸频率从83升至95次/min ,乳酸含量由初始值1.46 mmol/g prot 显著上升至2.37 mmol/g prot (P <0.01)。

皮尔逊相关分析显示鲜活虹鳟鱼的呼吸频率与乳酸含量、MDA 值、加压失水率呈现出极显著相关性(P <0.01),与糖原含量、AMP 含量、IMP 含量以及Hx 和HxR 总含量等肌肉品质呈现出显著相关性(P <0.05),相关系数分别为0.987、0.951、0.939、−0.897、0.847、0.896、0.882。

电感耦合等离子体质谱法测定金属锂中6种元素

电感耦合等离子体质谱法测定金属锂中6种元素

化学分析计量CHEMICAL ANALYSIS AND METERAGE第29卷,第4期2020年7月V ol. 29,No. 4Jul. 202035doi :10.3969/j.issn.1008–6145.2020.04.008电感耦合等离子体质谱法测定金属锂中6种元素郑亚蕾(中核建中核燃料元件有限公司,四川宜宾 644000)摘要 建立电感耦合等离子体质谱(ICP–MS )法同时测定金属锂中的钛、铬、锰、镍、钡和铅6种杂质元素。

样品用硝酸消解,在线加入混合内标元素,根据待测元素的质荷比不同以ICP–MS 技术进行分离,经质量分析器和检测系统,测试质谱的信号强度对元素进行定量分析。

6种杂质元素适用于He 模式下检测,样品酸度确定为0.15 mol /L 。

6种元素的质量浓度在1~100 μg /L 范围内与离子强度线性关系良好,相关系数均大于0.999,钛,铬,锰,镍,钡和铅元素检出限分别为0.059,0.065,0.048,0.074,0.062,0.071 μg /L ,测定结果的相对标准偏差为1.56%~3.94%,加标回收率为91.7%~109.4%。

该法操作简便、灵敏度高、准确度高,适用于金属锂中6种杂质元素的测定,提高了分析效率和检测水平。

关键词 电感耦合等离子体质谱法;检测;金属锂中图分类号:O657.6 文献标识码:A 文章编号:1008–6145(2020)04–0035–05Determination of six elements in lithium metal by inductively coupled plasma mass spectrometryZHENG Yalei( CNNC Jianzhong Nuclear Fuel Co., Ltd., Yibin 644000, China )Abstract An inductively coupled plasma mass spectrometry (ICP–MS) was established for the simultaneous determination of 6 impurity elements of titanium, chromium, manganese, nickel, barium, plumbum in lithium metal. Sample digestion with nitric acid and added internal standard elements online. ICP–MS separated the elements according to mass-to-charge ratio. Mass spectrometer and detection system detected signal intensity of mass spectrum to quantitative analysis for elements. Six kinds of impurity elements applied to He mode, and acidity of sample was 0.15 mol /L. The mass concentration of six elements had a good linear relationship with ion strength in the range of 1–100 μg /L, and correlation coefficient than 0.999, the detection limits of titanium, chromium, manganese, nickel, barium, plumbum were 0.059, 0.065, 0.048, 0.074, 0.062, 0.071 μg /L, respectively, the relative standard deviation of detection of results was 1.56%–3.94%, the recovery was 91.7%–109.4%. The method is simple, high sensitivity and high accuracy. It is suitable for determination of six impurity elements in lithium metal, which improve analysis efficiency and detection level.Keywords inductively coupled plasma mass spectrometry; determination; lithium metal金属锂是一种银白色、质软的轻金属,密度非常小,仅有0.534 g /cm³,被称为“高能金属”,广泛应用于电池材料、核电、军工、航空航天等行业。

制药行业专业英语词典

制药行业专业英语词典

Abbe refractometer 阿贝折射计 absorbance 吸光度absorbance ratio 吸光度比值 absorption curve 吸收曲线 absorption spectrum 吸收光谱 accuracy 准确度acid­base indicator 酸碱指示剂acid­base titration 酸碱滴定 acidimetry 酸量法acidity 酸度acid 酸acid­dye colorimetry酸性染料比色法 acid value 酸值acid­insoluble ash 酸不溶性灰分 action and use 作用与用途active constituent 活性成分 additive 添加剂additivity加和性adjusted retention time 调整保留时间 adsorption吸附affinity chromatography亲和色谱法 alkalinity 碱度alkaloid 生物碱alkyloxy determination 烷氧基测定alumina 氧化铝amino acid 氨基酸analysis error 分析误差analytical balance 分析天平analytical chemistry分析化学analysis of variance 方差分析analytical quality control(AQC)分析质量控制 angstrom,Å 埃anhydrous 无水的anhydrous basis,anhydrous substance 干燥品 antioxidant 抗氧剂apparatus error 仪器误差apparent viscosity 表观黏度appendix 附录application of sample 点样area normalization method 面积归一化法 argentimetry 银量法aromatic hydrocarbon 芳烃arsenic 砷arsenic stain 砷斑artificial neural network 人工神经网络artificial intelligence 人工智能ash 灰分assay含量测定asymmetrical stretching vibration 不对称伸缩振动 atmospheric pressure ionization(API)大气压离子化 atomic absorption spectrometry(AAS)原子吸收光谱法 attenuation衰减average 平均值average deviation 平均偏差back extraction 反萃取back titration 反滴定band absorption 谱带吸收bar graph 棒图baseline correction 基线校正 baseline drift 基线漂移base 碱baseline resolved peak 基线分离峰 batch,lot 批biotransformation 生物转化 bioequivalence 生物等效性 bioavailability 生物利用度blank test 空白试验blue shift 蓝移boiling range 沸程British Pharmacopeia (BP) 英国药典 bromate titration溴酸盐滴定法 bromocresol green 溴甲酚绿 bromocresol purple 溴甲酚紫 bromophenol blue 溴酚蓝 bromothymol blue 溴麝香草酚蓝 buffer action 缓冲作用buffer capacity 缓冲容量buffer solutions 缓冲溶液bulk drug,pharmaceutical product 原料药 buret 滴定管by­product 副产物calibrate 校准calibration curve 校准曲线calomel electrode 甘汞电极capacity factor 容量因子capillary electrophoresis(CE)毛细管电泳 capillary gas chromatography 毛细管气相色谱法 capillary melting point determination 毛细管熔点测定 carrier gas 载气capsule 胶囊剂characteristics,description 性状characteristic spectrum 特征光谱chemical constituent 化学成分chemical drugs 化学药品check sample 对照试样check test 对照试验chelate compound 螯合物chemically bonded phase 化学键合相chemical equivalent 化学当量Chinese Pharmacopoeia (ChP) 中国药典Chinese patent medicine 中成药Chinese materia medica 中药学Chinese materia medica preparation 中药制剂Chinese Pharmaceutical Association (CPA)中国药学会 chiral stationary phase(CSP)手性固定相chiral separation手性分离chirality手性chiral carbon atom手性碳原子chiral molecule 手性分子chloride 氯化物chromatography 色谱法chromatogram色谱图chromatographic column 色谱柱chromatographic condition 色谱条件 chromatographic system 色谱系统chromatographic data processor 色谱数据处理机 chromatographic work station 色谱工作站cis­trans isomerism顺反异构clarity澄清度clathrate, inclusion compound 包合物clearance 清除率clinical pharmacy 临床药学coefficient of distribution 分配系数coefficient of variation 变异系数coenzyme 辅酶color reaction 显色反应colorimetric analysis 比色分析column capacity 柱容量column dead volume 柱死体积column interstitial volume 柱隙体积column outlet pressure 柱出口压column temperature 柱温column pressure 柱压column volume 柱体积column overload 柱超载column switching柱切换committee of drug evaluation药品审评委员会 complex 络合物component,constituent 组分compound medicines 复方药concentration浓度controlled trial对照试验coordination compound 配位化合物 correlation coefficient 相关系数 comparative test 比较试验completeness of solution 溶液的澄清度 complexometric titration 络合滴定computer­aided pharmaceutical analysis 计算机辅助药物分析 condensation reaction缩合反应condensation substance 缩合物confidence interval 置信区间confidence level 置信水平confidence limit 置信限confidence probability 置信概率congealing point 凝点content 含量,内含物content uniformity 装量差异contrast test 对照试验crude drug 生药crystal结晶crystal violet 结晶紫crystallinity 结晶性(结晶度)cyclodextrin inclusion compound 环糊精包合物cyanide 氰化物dead space 死体积dead­stop titration永停滴定法dead time 死时间decomposition point 分解点deflection偏差deflection point 拐点degassing脱气deionized water 去离子水derivative spectrophotometry导数分光光度法detection 检查dextrose 右旋糖,葡萄糖diastereomer 非对映(异构)体diazotization titration method 重氮化滴定法2,6­dichlorindophenol titration2,6­二氯靛酚滴定法 differential thermal analysis(DTA) 差示热分析 differential scanning calorimetry(DSC)差示扫描热量法 differential pulse polarography示差脉冲极谱法 digestion 消化dilute 稀释diphasic titration 双相滴定direct potentiometry直接电位法dissociation constant 解离常数dissociation degree 解离度distribution chromatography 分配色谱distribution coefficient 分配系数dissolubility 溶解度dissolution溶出度disintegration 崩解时限distillation 蒸馏dose 剂量drug release 药物释放度drug quality management 药品质量管理drug control institutions 药检机构drug 药物drug metabolism enzyme 药物代谢酶drug quality control药品质量控制drug standard 药品标准dryness 干燥dual wavelength spectrophotometry 双波长分光光度法 duplicate test 重复试验excipient 赋形剂effective constituent 有效成分efficacy 效能,有效性effective plate number 有效板数efficiency of column 柱效electron transition 电子跃迁electrospray interface 电喷雾接口 electromigration injection电迁移进样elution洗脱eluting effect 洗脱效应elution curve 洗脱曲线elimination 消除emission spectrochemical analysis 发射光谱分析 end absorption末端吸收end point correction 终点校正end point error 终点误差enantiomer 对映(异构)体enzyme immunoassay(EIA)酶免疫分析 enzyme drug 酶类药物enzymatic reaction 酶促反应enzyme induction酶诱导enzyme inhibition 酶抑制epimer 差向异构体epimerization 差向异构化equilibrium constant 平衡常数 equivalence point 等当点equivalence potential等当点电位 equivalent weight 当量error in volumetric analysis 容量分析误差 extraction提取extract 提取物excite 激发excitation spectrum 激发光谱excitation wave length 激发波长 exclusion chromatography 排阻色谱法 expiration date 失效期external standard 外标准extrapolated method 外插法,外推法 expert system专家系统extraction gravimetry 提取重量法 extraction titration提取容量法factor 系数,因数feature 特征Fehling’s reaction费林反应fineness of the particles 颗粒细度finger print region指纹区finger print map 指纹图fixed phase 固定相flame ionization detector (FID)火焰离子化检测器flame emission spectrum 火焰发射光谱fluorimetry 荧光分析法fluorescamine 荧胺fluorescence immunoassay(FIA)荧光免疫分析fluorescence polarization immunoassay(FPIA)荧光偏振免疫分析 fluorescent agent 荧光剂fluorescence spectrophotometry 荧光分光光度法fluorescence detector 荧光检测器fluorescence efficiency 荧光效率fluorescence excitation spectrum 荧光激发光谱foreign odor 异臭foreign pigment 有色杂质formulary处方集freezing test 结冻试验functional group 官能团fused peaks, overlapped peaks 重叠峰gas chromatogram 气相色谱图gas chromatography (GC)气相色谱法gas chromatograph­flourier transform infrared spectrophotometer 气相 色谱­傅里叶变换红外光谱联用仪glass electrode 玻璃电极gas­liquid chromatography (GLC) 气液色谱法gas purifier 气体净化器gel chromatography凝胶色谱法general identification test 一般鉴别试验gradient elution 梯度洗脱Good Manufacturing Practice and Quality Control of Drug (GMP and QC of Drug)药品生产质量管理规范Good Manufacture Practices(GMP) 药品生产规范Good Laboratory Practice(GLP)实验室管理规范Good Clinical Practice(GCP)临床试验规范Good Supplying Practice(GSP)药品供应规范Gran’s plot 格兰作图法gravimetric analysis 重量分析法half peak width 半峰宽[halide]disk method,wafer method,pellet method 压片法head­space concentrating injector 顶空浓缩进样器heat conductivity 热导率heavy metal重金属height of an effective plate 有效板高度high resolution gas chromatography(HRGC)高分辨气相色谱法hgh­performance liquid chromatography高效液相色谱法high performance thin­layer chromatography(HPTLC)高效薄层色谱 法hydroxyl value 羟值hyperchromic effect 深色效应hypsochromic effect 浅色效应hypothesis test 假设检验hydrophobicity 疏水性hydrophilicity亲水性hydrate 水合物hydrolysis 水解identification 鉴别immobile phase 固定相impurity 杂质Inactivation 失活index 索引indicator 指示剂indicator electrode 指示电极inhibitor抑制剂infrared absorption spectrum 红外吸收光谱 injecting septum 进样隔膜胶垫injection valve 进样阀integrator积分仪instrumental analysis仪器分析instrument error 仪器误差intermediate 中间体international unit(IU)国际单位internal standard substance 内标物质 iodometry 碘量法ion exchange chromatography 离子交换色谱法 ionic strength 离子强度ionize 电离ion pair chromatography 离子对色谱ion suppression 离子抑制 irreversible potential不可逆电位 isoelectric point 等电点isoosmotic solution 等渗溶液 immunoassay 免疫测定ion­exchange cellulose离子交换纤维素 iodoform reaction 碘仿反应ion suppress 离子抑制iodide碘化物irreversible indicator不可逆指示剂 isosbestic point method等吸光点法课外阅读一 阿司匹林及其片剂的质量标准(USP )Aspirin O O H 3C HOOC 9H 8O 4 180.16Benzoic acid, 2­(acetyloxy)­Salicylic acid acetate [50­78­2].>>Aspirin contains not less than 99.5 percent and not more than 100.5 percent of C 9H 8O 4, calculated on the dried basis. Packaging and storage ­Preserve in tight containers.USP Reference standards <11>-USP Aspirin RS .Identification -A : Heat it with water for several minutes, cool, and add 1 or 2 drops of ferric chloride TS: a violet­red color is produced.B : Infrared Absorption <197K>Loss on drying <731>-Dry it over silica gel for 5 hours: it loses not more than 0.5% of its weight.Readily carbonizable substances <271>-Dissolve 500mg in 5 mL of sulfuric acid TS: the solution has no more color than Matching Fluid Q.Residue on ignition <281>: not more than 0.05%.Substances insoluble in sodium carbonate TS -A solution of 500mg in 10 mL of warm sodium carbonate TS is clear.Chloride <221>-Boil 1.5g with 75 mL of water for 5 minutes, cool, add sufficient water to restore the original volume, and filter. A 25­mL portion of the filtrate shows no more chloride than corresponds to 0.10 mL of 0.020 N hydrochloric acid (0.014%).Sulfate ­Dissolve 6.0g in 37 mL of acetone, and add 3 mL of water. Titrate potentiometrically with 0.02 M lead perchlorate, prepared by dissolving 9.20 g of lead perchlorate in water to make 1000mL of solution, using a pH meter capable of a minimum reproducibility of ±0.1 mV (see pH <791>) equipped with an electrode system consisting of a lead­specific electrode and a silver­silver chloride reference glass­sleeved electrode containing a solution of tetraethylammonium perchlorate in glacial acetic acid (1 in 44)(see Titrimetry <541>): not more than 1.25mL of 0.02 M lead perchlorate is consumed (0.04%). [NOTE -After use, rinse the lead­specific electrode with water, drain the reference electrode, flush with water, rinse with methanol, and allow to dry.]Heavy metals -Dissolve 2 g in 25 mL of acetone, and add 1 mL of water. Add 1.2 mL of thioacetamide­glycerin base TS and 2 mL of pH 3.5 Acetate Buffer (see Heavy Metals <231>), and allow to stand for 5 minutes: any color produced is not darker than that of a control made with 25 mL of acetone and 2 mL of Standard Lead Solution (see Heavy Metals <231>), treated in the same manner. The limit is 10μg per g.Limit of free salicylic acid-Dissolve 2.5g in sufficient alcohol to make 25.0 mL. To each of two matched color­comparison tubes add 48 mL of water and 1 mL of a freshly prepared, diluted ferric ammonium sulfate solution (prepared by adding 1 mL of 1 N hydrochloric acid to 2 mL of ferric ammonium sulfate TS and diluting with water to 100 mL). Into one tube pipet 1 mL of a standard solution of salicylic acid in water, containing 0.10 mg of salicylic acid per mL. Into the second tube pipet 1 mL of the 1 in 10 solution of Aspirin. Mix the contents of each tube: after 30 seconds, the color in the second tube is not more intense than that in the tube containing the salicylic acid (0.1%).Organic volatile impurities, Method IV<467>: meets the requirements.Assay-Place about 1.5g of Aspirin, accurately weighed, in a flask, add 50.0 mL of 0.5 N sodium hydroxide VS, and boil the mixture gently for 10 minutes. Add phenolphthalein TS, and titrate the excess sodium hydroxide with 0.5 N sulfuric acid VS. Perform a blank determination (see Residual Titrations under Titrimetry <541>). Each mL of 0.5 N sodium hydroxide is equivalent to 45.04 mg of C9H8O4.Aspirin Tablets>> Aspirin Tablets contain not less than 90.0 percent and not more than 110.0 percent of the labeled amount of C9H8O4. Tablets of larger than 81­mg size contain no sweeteners or other flavors.N OTE­Tablets that are enteric­coated meet the requirements for Aspirin Delayed­release Tablets.Packaging and storage­Preserve in tight containers. Preserve flavored or sweetened Tablets of 81­mg size or smaller in containers holding not more than 36 Tablets each.USP Reference standards <11>­USP Aspirin RS. USP Salicylic Acid RS.Identification­A: Crush 1 Tablet, boil it with 50 mL of water for 5 minutes, cool, and add 1 or 2 drops of ferric chloride TS: a violet­red color is produced.B: Infrared absorption <197K>­Prepare the test specimen as follows. Shake a quantity of finely powdered Tablets, equivalent to about 500 mg of aspirin, with 10 mL of alcohol for several minutes. Centrifuge the mixture. Pour off the clear supernatant liquid, and evaporate it to dryness. Dry the residue in vacuum at 60℃ for 1 hour.Dissolution<711>­Medium: 0.5 M acetate buffer, prepared by mixing 2.99 g of sodium acetate trihydrate and 1.66 mL of glacial acetic acid with water to obtain 1000mL of solution having a pH of 4.50±0.05; 500 mL.Apparatus 1 : 50 rpm.Time: 30 minutes.Procedure-Determine the amount of C9H8O4 dissolved from ultraviolet absorbances at the wavelength of the isosbestic point of aspirin and salicylic acid at 265±2nm of filtered portions of the solution under test, suitably diluted with Dissolution Medium. if necessary, in comparison with a Standard solution having a known concentration of USP Aspirin RS in the samemedium. [N OTE­Prepare the Standard solution at the time of use. An amount of alcohol not to exceed 1% of the total volume of the Standard solution may be used to bring the Reference Standard into solution prior to dilution with Dissolution Medium.] Tolerances­Not less than 80% (Q) of the labeled C9H8O4 is dissolved in 30 minutes.Uniformity of dosage units <905>: meet the requirementsLimit of free salicylic acid­Mobile phase and Diluting Solution­Prepare as directed in the Assay.Standard solution­Dissolve an accurately weighed quantity of USP Salicylic Acid RS in the Standard preparation prepared as directed in the Assay, to obtain a solution having a known concentration of about 0.015 mg of salicylic acid per mL.Test preparation­Use the Stock solution prepared as directed for Assay preparation in the Assay.Chromatographic system­Use the Chromatographic system described in the Assay. Chromatograph the Standard solution, and record the peak responses as directed under Procedure in the Assay. The relative standard deviation of the salicylic acid peak responses is not more than 4.0%. In a suitable chromatogram, the resolution, R, between salicylic acid and aspirin is not less than 2.0.Procedure­Proceed as directed for Procedure in the Assay. The relative retention times are about 0.7 for salicylic acid and 1.0 for aspirin. Calculate the percentage of salicylic acid (C7H6O3) in the portion of Tablets taken by the formula:2000(C/Q A)(r u/r s),in which C is the concentration, in mg per mL, of USP Salicylic Acid RS in the Standard solution, Q A is the quantity, in mg, of aspirin (C9H8O4) in the portion of Tablets taken, as determined in the Assay, and rυ and r s are the peak responses of the salicylic acid peaks obtained from the Test preparation and the Standard solution, respectively: not more than 3.0% is found. In the case that are coated, not more than 3.0% is found.Assay­Mobile phase­Dissolve 2 g of sodium 1­heptanesulfonate in a mixture of 850 mL of water and 150 mL of acetonitrile, and adjust with glacial acetic acid to a pH of 3.4.Diluting solution­Prepare a mixture of acetonitrile and formic acid (99:1).Standard preparation­Dissolve an accurately weighed quantity of USP Aspirin RS in Diluting solution to obtain a solution having a known concentration of about 0.5 mg per mL.Assay preparation­Weigh and finely powder not less than 20 Tablets. Transfer an accurately weighed quantity of the powder, equivalent to about 100 mg of aspirin, to a suitable container. Add 20.0 mL of Diluting solution and about 10 glass beads. Shake vigorously for about 10 minutes, and centrifuge (stock solution). Quantitatively dilute an accurately measured volume of the Stock solution with 9 volumes of Diluting solution (Assay preparation). Retain the remaining portion of Stock solution for the test for Limit of salicylic acid.Chromatographic system (see Chromatography <621>)-The liquid chromatograph is equipped with a 280­nm detector and a 4.0­mm×30­cm column containing packing L1. The flow rate is about 2 mL per minute. Chromatograph the Standardpreparation, and record the peak responses as directed under Procedure: the relative standard deviation is not more than 2.0%. In a suitable chromatogram, the tailing factor is not greater than 2.0.Procedure­Separately inject equal volumes (about 10m L) of the Standard preparation and the Assay preparation into the chromatograph, record the chromatograms, and measure the responses for the major peaks. Calculate the quantity, in mg, of aspirin (C9H8O4) in the portion of Tablets taken by the formula:200C(rυ/r s),in which C is the concentration, in mg per mL, of USP Aspirin RS in the Standard preparation, and rυ and r s are the peak responses of the aspirin peaks obtained from the Assay preparation and the Standard preparation, respectively.课外阅读二 分析方法论证ANALYTICAL PERFORMANCE CHARACTERISTICSAccuracyDefinition­The accuracy of an analytical method is the closeness of test results obtained by that method to the true value. The accuracy of an analytical method should be established across its range.Determination­In the case of the assay of a drug substance, accuracy may be determined by application of the analytical method to an analyte of known purity (e.g., a Reference Standard) or by comparison of the results of the method with those of a second, well­characterized method, the accuracy of which has been stated or defined.In the case of the assay of a drug in a formulated product, accuracy may be determined by application of the analytical method to synthetic mixtures of the drug product components to which known amounts of analyte have been added within the range of the method. If it is not possible to obtain samples of all drug product components, it may be acceptable either to add known quantities of the analyte to the drug product (i.e., “to spike”) or to compare results with those of a second, well­characterized method, the accuracy of which has been stated or defined.In the case of quantitative analysis of impurities, accuracy should be assessed on samples (of drug substance or drug product) spiked with known amounts of impurities. Where it is not possible to obtain samples of certain impurities or degradation products, results should be compared with those obtained by an independent method. In the absence of other information, it may be necessary to calculate the amount of an impurity based on comparison of its response to that of the drug substance; the ratio of the responses of equal amounts of the impurity and the drug substance (response factor) should be used if known.Accuracy is calculated as the percentage of recovery by the assay of the known added amount of analyte in the sample, or as the difference between the mean and the accepted true value, together with confidence intervals.The ICH documents recommend that accuracy should be assessed using a minimum of nine determinations over a minimum of three concentration levels, covering the specified range (i.e., three concentrations and three replicates of each concentration).PrecisionDefinition­The precision of an analytical method is the degree of agreement among individual test results when the method is applied repeatedly to multiple samplings of a homogeneous sample. The precision of an analytical method is usually expressed as the standard deviation or relative standard deviation (coefficient of variation) of a series of measurements. Precision may be a measure of either the degree of reproducibility or of repeatability of the analytical method under normal operating conditions. In this context, reproducibility refers to the use of the analytical procedure in different laboratories, as in a collaborative study. Intermediate precision expresses within­laboratory variation, as on different days, or with different analystsor equipment within the same laboratory. Repeatability refers to the use of the analytical procedure within a laboratory over a short period of time using the same analyst with the same equipment. For most purposes, repeatability is the criterion of concern in USP analytical procedures, repeatability is the criterion of concern in USP analytical procedures, although reproducibility between laboratories or intermediate precision may well be considered during the standardization of a procedure before it is submitted to the Pharmacopeia.Determination­The precision of an analytical method is determined by assaying a sufficient number of aliquots of a homogeneous sample to be able to calculate statistically valid estimates of standard deviation or relative standard deviation (coefficient of variation). Assays in this context are independent analyses of samples that have been carried through the complete analytical procedure from sample preparation to final test result.The ICH documents recommend that repeatability should be assessed using a minimum of nine determinations covering the specified range for the procedure (i.e., three concentrations and three replicates of each concentration or using a minimum of six deter minations at 100% of the test concentration).SpecificityDefinition­The ICH documents define specificity as the ability to assess unequivocally the analyte in the presence of components that may be expected to be present, such as impurities, degradation products, and matrix components. Lack of specificity of an individual analytical procedure may be compensated by other supporting analytical procedures. [N OTE­Other reputable international authorities (IUPAC, AOAC) have preferred the term “selectivity”, reserving “specificity” for those procedures that are completely selective.] For the test or assay methods below, the above definition has the following implications:IDENTIFICA TION TESTS: ensure the identity of the analyte.PURITY TESTS: ensure that all the analytical procedures performed allow an accurate statement of the content of impurities of an analyte (e.g., related substances test, heavy metals limit, organic volatile impurity limit).ASSAYS: provide an exact result, which allows an accurate statement on the content or potency of the analyte in a sample.Determination­In the case of qualitative analyses (identification tests), the ability to select between compounds of closely related structure that are likely to be present should be demonstrated. This should be confirmed by obtaining positive results (perhaps by comparison to a known reference material) from samples containing the analyte, coupled with negative results from samples that do not contain the analyte and by confirming that a positive response is not obtained from materials structurally similar to or closely related to the analyte.In the case of analytical procedure for impurities, specificity may be established by spiking the drug substance or product with appropriate levels of impurities and demonstrating that these impurities are determined with appropriated accuracy and precision.In the case of the assay, demonstration of specificity requires that it can be shown that the procedure is unaffected by the presence of impurities or excipients. In practice, this can be done by spiking the drug substance or product with appropriatelevels of impurities or excipients and demonstrating that the assay result is unaffected by the presence of these extraneous materials.If impurity or degradation product standards are unavailable, specificity may be demonstrated by comparing the test results of samples containing impurities or degradation products to a second well­characterized procedure (e.g., a pharmacopeial or other validated procedure). These comparisons should include samples stored under relevant stress conditions (e.g., light, heat, humidity, acid/base hydrolysis, oxidation). In the case of the assay, the results should be compared; in the case of chromatographic impurity tests, the impurity profiles should be compared.The ICH documents state that when chromatographic procedures are used, representative chromatograms should be presented to demonstrate the degree of selectivity, and peaks should be appropriatedly labeled. Peak purity tests (e.g., using diode array or mass spectrometry) may be useful to show that the analyte chromatographic peak is not attributable to more than one component.Detection LimitDefinition­The detection limit is a characteristic of limit tests. It is the lowest amount of analyte in a sample that can be detected, but not necessarily quantitated, under the stated experimental conditions. Thus, limit tests merely substantiate that the amount of analyte is above or below a certain level. The detection limit is usually expressed as the concentration of analyte (e.g., percentage. parts per billion) in the sample.Determination­For noninstrumental methods, the detection limit is generally determined by the analysis of samples with known concentrations of analyte and by establishing the minimum level at which the analyte can be reliably detected.For instrumental procedures, the same method may be used as for noninstrumental. In the case of methods submitted for consideration as official compendial methods, it is almost never necessary to determine the actual detection limit. Rather, the detection limit is shown to be sufficiently low by the analysis of samples with known concentration of analyte above and below the require detection vevel. For example, if it is required to detect an impurity at the level of 0.1%, it should be demonstrated that the procedure will reliably detect the impurity at that level.In the case of instrumental analytical procedures that exhibit back ground noise, the ICH documents describe a common approach, which is to compare measure signals from samples with known low concentrations at which the analyte can reliably be detected is established, Typically acceptable signal­to­noise ratios are 2:1 or 3:1. Other approaches depend on the determination of the slope of the calibation curve and the standard deviation of responses. Whatever method is used, the detection limit should be subsequently validated by the analysis of a suitable number of samples known to be near, or prepared at, the detection limit.Quantitation Limit­Definition­The quantitation limit is a characteristic of quantitative assays for low levels of compounds in sample matrices, such as impurities in bulk drug substances and degradation products in finished pharmaceuticals. It is the lowest amount of analyte in a sample that can be determined with acceptable precision and accuracy under the stated experimental conditions.。

FDA仿制药研发指南(原文 明胶软胶囊)

FDA仿制药研发指南(原文 明胶软胶囊)

PRODUCT DEVELOPMENT GUIDEP RE-FORMULATION - SOFT GELATIN CAPSULES IntroductionGuidelines for the development of a ANDA product for the US market, Note: some tests or procedures may be unnecessary. The order of performing the various stages may change depending on the product under development. These guidelines may be modified for other geographic zones.Development Stage Scope of Product DevelopmentStage 1L i t e r a t u r e S e a r c hLiterature Research USP BP Pharm. Eur, PDR, Martindale, Merck, Florey, Vidal,Text and journalsFDA - FOI Summary Basis of Approval - On request form FDAOn-line computerized searchFDA CDER Electronic Data Base (articles and publication on test methods, Dissolution synthesis procedures, drug impurities, pharmacokinetics and dynamics)Evaluation of Biostudy parameters, Dissolution methods.Patent evaluation Orange Guide + FDA CDER WWW Patent Consultant Stage 2A c t i v e S o u r c i n gSourcing for Active Raw Material International Suppliers US, European, Asian, e.g. (ACIC-Canada) (AllChem-UK) (Lek-Czech), (Esteves; Moehs; Uquifa-Spain); (Biopharma, S.I.M, Midy-Italy) (Chemcaps, Reddy; Tricon-India); (Federa-Brussels) - Review suppliers catalogs & data critically.Potential Suppliers List Request samples and C of A and Specifications Evaluate at least two suppliers fully.Stage 3A c t i v e E v a l u a t i o nEvaluate Potential Actives Evaluate at least two or maximum three potential active suppliers• DMF availability• Compliance with USP monograph• Impurity profile and stability• Potential Polymorphic forms• Commitment for physical specifications (Bulk Density)• Statement of non-patent infringementStage 4A c t i v e P u r c h a s i n gPurchase (Potential) Active Material Evaluate at least two potential active material suppliers for approved supplier statusStage 5A c t i v e T e s t i n gTesting of Active Material sample Chemical testing by the R&D analytical lab as pera. Pharmacopoeia monograph (if present)b. Pharmacopoeia Forum (if available)c. In-house method (based on manufacturer)d. Supplier's test methods and specificationPRE-FORMULATION - SOFT GELATIN CAPSULES DevelopmentStageScope of Product Development Stage 6I n n o v a t o r's P r o d u c t P u r c h a s i n gDRUG PRODUCT Innovator Samples Purchase at least 3 different lots in smallest and largest pack size for each product strengthStage 7I n n o v a t o r's P r o d u c t T e s t i n gInnovator Testing Evaluate physical parameters:-Capsule size, capsule color / US approved dyes, coding forprinting, pack sizes containers materials, closure types;cotton and desiccants, blister packaging.Innovator Physical Testing Physical testingFill Weight & Uniformity; Shell disintegration & Dissolution Evaluation of capsule size and volume w.r.t. fill volumeEvaluation of Innovator formula ingredients Summary Formula in PDR; International PDRs (Italian, French, Swiss) and Innovators product's insert (obtain latest FOI -FDA)Perform actual analytical testing on innovator's product.Microscopic observation Particle/crystal information on:Particle size, crystal shape, habit, rugosity Viscosity agents used (PVP 30 / 90) Presence of vegetable oil (type) Presence of PEG 400Presence of polyethylene glycol solventEvaluation of Biostudy Review FDA CDER Home page for listing and Biostudy parametersDissolution profile USP monograph and FDA method - (where present)Dissolution; 12 unit Dissolution Profile.Stage 8B u l k A c t i v e T e s t i n gFIRST BATCH FROM APPROVED SUPPLIERFull Physical characterization Physical characterization of bulk batch• Polymorphism• B.E.T.• Particle size distribution (& method development)• Bulk and Tapped density (Need for size reduction of material)• Microscopic observationFULL CHEMICAL CHARACTERIZATI ON Chemical characterization • Assay• Stressed Analysis• Degradants (Expected)• Impurity profile• Optical rotation• Enantiomeric purity• O.V.I. TestingDEVELOPMENT BATCHES - SOFT GELATIN CAPSULES Development Stage Scope of Product DevelopmentStage 9E x c i p i e n t sEvaluate formulation with suitable excipients • Vegetable oil solubility / PEG 400 / PEG 600 / PG / PVP 30• Antioxidants (dl-alpha Tocopherol (Vit. E USP) / Propyl gallate)Stage 10C o n t a i n e r C l o s u r e S y s t e mEvaluation of suitableContainer-Closure System Choice of container-closure-liner system including:• material composition,• type of thermoplastic resin and resin pigments,• manufacturers and suppliers,• liners and seals used by closure manufacturer,• cotton and desiccants.• manufacturer's DMF numbers for all component parts• Letters of Access for regulatory authorities to view DMF dossiersStage 11M a n u f a c t u r i n g P r o c e s sEVALUATION SUITABLE MANUFACTURING PROCESSES Gelatin MassFill Preparation Encapsulation Drying stages • Gel mass blending (rpm & time)• Gel mass melting (temperature and vacuum)• Gel mass color addition (temperature and rpm & time)• Gel mass VISCOSITY and MOISTURE determination • Gel mass deaeration (holding time)• Fill mass (mixing rpm, time & propeller position)• Determination of Fill mass viscosity / SG / moisture• Determination of Bulk Uniformity Analysis• Wet shell weight / Fill weight• Seal thickness• Determination of Drying Parameters• Determination of rotary tumbler drying parameters & time • Determination of primary and secondary tray drying times • Determine Bareiss hardnessFill material Physical Properties of oil or paste fill • Viscosity - (Critical)• Fill moisture• SG (helps to control deaeration)FillingPhysical Properties of Filled Softgels • Weight Uniformity• Individual Fill Weight Limits (7.5%)• Content Uniformity • Average Fill Weight Limits (5.0%)• Disintegration• Dissolution profileFinal Formula Established Assessment of Final Master Formula and accelerated 1-3 month stability profile.Stage 12B u l k A c t i v e P u r c h a s e dActive material Bulk purchase Ordering of Active material for Process Qualification (PQ) and Pivotal Batch(es). On approval of final formula, order sufficient material for the PQ (2) and Pivotal Lots (sufficient for all strengths and batch sizes).NB: Never mix batch numbers in PQ and Pivotal Lots.FULL LABORATORY EVALUATION - SOFTGELS Development Scope of Product DevelopmentStage 13A n a l y t i c a l E v a l u a t i o nAnalytical testing of Softgels • Dissolution - in USP medium (Multipoint profiles) and other relevant media versus Innovator's product. Dissolution testing may not be possible where active strength is in micrograms (i.e. 0.25 or 0.5 mcg)• U of C-for low active concentrations. Refer to USP requirements for uniformity of content vs. uniformity of dosage units.• Validation of analytical package i.e. Assay; Dissolution ; Content Uniformity completed prior to Process QualificationPROCESS OPTIMIZATIONDevelopment Scope of Product Development Stage 14P r o c e s s O p t i m i z a t i o nGEL & FILL MATERIAL OPTIMIZATION [In suspension and paste fills size reduction of active material may be necessary i.e. to decrease active bulk densities from 0.6 -0.75g/cc to 0.35 - 0.45 g/cc]◊ Optimization of gel mass moisture (once per shell formula)◊ Optimization of gel mass viscosity (once per shell formula)◊ Deaeration of gel mass - (critical)◊ Optimization of antioxidant percentage.◊ Mixing process - rpm ; mixing time ; propeller position◊ Fill material uniformity◊ Ribbon Thickness adjustments for correct shell weights (once per shell formula)◊ Seal Thickness (once per shell formula NLT 0.006")1◊ Wet Shell Weight variation (± 8%)1◊ Fill Weight variation (± 2%)1◊ 1 Process capability performed.DRYING♦ Drying time temperature versus shell moisture (in rotarydryer)♦ Primary drying time versus shell moisture (in tray dryer)♦ Secondary drying time versus shell moisture (in traydryer)♦ Bareiss hardness versus drying times.♦ Softgel properties (Fill weights and Content Uniformity).♦ Evaluation of Fill weight Range Limits (Qualification)♦ Evaluation of stability results of optimized mfg. Process.♦ Printing Inspection LimitsPROCESS OPTIMIZATION REPORT (PO)Prepare PO Report.This Process Optimization Report forms part of the product Development ReportESTABLISHING AND INVITRO INVIVO CORRELATION DevelopmentScope of Product Development Stage 15A n a l y t i c a l E v a l u a t i o n IVIV Correlation(search literature)• Dissolution - in USP medium (Multipoint profiles) and other relevant media versus Innovator's product. Dissolutiontesting may not be possible where active strength is inmicrograms (i.e. 0.25 or 0.5 mcg)• Perform IVIV Bioavailability Study (where relevant)BSC System IVIVC 1 : 1 Correlation Dissolution settings Plasma parameters D evelopers are encouraged to develop IVIVC for IR dosageforms, where applicable to the BCS, (BiopharmaceuticalClassification System) in the expectation that the informationwill be useful in establishing appropriate dissolutionspecifications and thus permit certain post approvalformulation and manufacturing changes to be effected, -without additional bioequivalence studies.T he objective of developing an IVIVC is to establish apredictive mathematical model describing the relationshipbetween invitro dissolution settings and the actual invivodrug-plasma parameters found, (such as AUC, Cmax,Tmax).T he invitro dissolution settings are adjusted (via media, pHagitation) until a I : I correlation is achieved (Level A) or asingle dissolution point and a plasma parameter is shown tocorrelate (Level C).When more than one point correlates a multiple Level C isobtained - which may possibly be upgraded to a Level Awith additional development work.T his matching of dissolution settings with plasma levels, thatare derived from a specific IR formula and its correspondingmanufacturing process, is in fact simply an arbitrary set ofvalues that establish the so called 'predictive mathematicalmodel'.A n IVIVC should be evaluated to demonstrate thatpredictability of the invivo performance of the drug product(i.e. derived from the plasma parameters) from its in vitrodissolution characteristics (e.g. equipment settings / andmanufacturing changes) is maintained over the product'sdissolution profile.Not applicable to highly soluble materials Establish a Level A or C correlation without adjustingdissolution parameters and time scale.Not applicable to highly solublematerials• Adjust the dissolution parameters or time scale to achievea Level A or C correlation (adjust only if necessary)SCALE UPDevelopmentStageScope of Product DevelopmentStage16S c a l e-u pScale-up S cale-up lot prepared if larger batch size scale up problemsanticipated.S cale-up of gel massS cale-up of fill material (N2 atmosphere and final filtration)S cale-up of encapsulation procedure (seal thickness)S cale-up of primary and secondary drying (Time &moisture)S cale-up of sorting, sizing and printing.P rocess Qualification batch and Scale-up batch may beevaluated as a single batch.Scale-up Report T he preparation of a Scale-up Report. The Scale-up reportforms part of the overall Development Report PROCESS QUALIFICATIONDevelopmentStageScope of Product DevelopmentStage 17P r o c e s s Q u a l i f i c a t i o nT he process qualification batch is manufactured in order to detect any problems that may arise during the manufacture of production size batches, allowing a solution prior the manufacture of the pivotal demonstration batch.S cale-up to the pivotal batch size or 70% of the pivotal batch may be combined with qualifying the manufacturing process.A t this stage full manufacturing documentation is prepared alone standard procedures.PRODUCTION FACILITIES P rocess Qualification batch should be executed on a commercial production (or production type with same principle and operation) encapsulating machine in a production setting.The primary dryer and secondary tray or tunnel dryingequipment should be identical or similar.S ize of pivotal and marketing batch confirmed (NLT 100 000 net/ packed at target parameters or 10% of proposed market batch).Ideally for Soft Gelatin Capsules 120 000 - 150 000 or more units should be prepared for pivotal batch to allow for some level of qualification by testing and challenging both ends of the selected specification limits.BATCH DOCUMENTATION P reparation of Master Formula and Processing InstructionsDiscussion of formula, manufacturing process and control parameters with production personnel and QA StaffPROCESS QUALIFICATION - SOFTGELS Development Stage Scope of Product Development Stage 17 (Cont)P r o c e s s Q u a l i f i c a t i o nFINAL REVIEW and AUTHORIZATION Review of proposed formula, manufacturing process and control parameters with production personnel and QA Staff with authorization signatures (RD; QA-QC; RA; and Production)PROTOCOL PQ. protocol preparedKEY STEPS Critical manufacturing steps designated and sampling andtesting parameters specified.OPERATING CONDITIONS Presence of production and control personnel during PQ manufacturePQ REPORT Upon completion prepare Process Qualification Report. ThisP-Q report forms part of the overall Development Report PIVOTAL BATCHDevelopment Scope of Product DevelopmentStage 18P i v o t a l P r o d u c t i o nPRODUCTION FACILITIES Pivotal batch MUST be compressed in a production Encapsulating machine (or production type with same principle and operation)BATCH DOCUMENTATION Preparation of FINAL Master Formula and Processing InstructionsREVIEW and AUTHORIZATION Review of FINAL formula, manufacturing process and control parameters with production personnel and QA Staff. Pivotal authorization signatures (RD; QA-QC; RA; and Production) attached.OPERATING CONDITIONS Operation of production and control personnel during Pivotal manufacture, aided by development team.REPORT The preparation of a Pivotal Report. This pivotal reportforms partof the overall Development Report. BIOEQUIVALENT STUDYStage Scope of Product DevelopmentStage19B I O S T U D Y E v a l u a t i o nBIOSTUDY Fasted Perform Fasted / Food Effect Biostudy on Pivotal LotSamplesBIOSTUDY [Food Effect]Perform Food Effect Biostudy on Pivotal Lot Samples (See food effect guidelines, where appropriate)HIGHEST DOSAGE Biostudy generally performed on highest strength of product One or two studies Fasted AND Food Effect Study may be requiredWAIVER CONDITIONS For multiple strength products Invitro dissolution testing conducted in three different pH media on lower dosage formsSIMILARITYTESTINGPerform Similarity Test [F2 Test] on dissolution results.PRE-SUBMISSION AUDITING - SOFTGELSDevelopment Stage Scope of Product DevelopmentStage20A N D A P r e-S u b m i s s i o n A u d i t i n gDevelopmentReportAudit all raw data supporting Development ReportANDA RegulatoryFileAudit Plant and Laboratory Documentation as per ANDA SOPs Review SOP System and Update levelcGMP Review cGMP of Manufacturing ProcessesBiostudy Report Evaluate and develop a IVIV correlation (Level A wherepossible.)Validation Protocol Product Process Validation Protocol complete and signed A NDA SUBMISSION - SOFTGELSDevelopment Stage Scope of Product DevelopmentStage21A N D A S u b m i s s i o nANDA Submission Submit ANDA structured carefully as per Feb. 1999Guidelines(9 Copies -as per Color system)(1 Field Copy)V ALIDATION BATCHESDevelopmentStageScope of Product DevelopmentStage 22P r o c e s s V a l i d a t i o nProtocol Process Validation Protocol for 3 consecutive marketing lots Execute validation Process Validation of 3 consecutive marketing lotsReport Process Validation ReportSimilarity Show intra-batch similarityBio-Validation Similarity Show inter-batch similarity between Biobatch (Pivotal) and the Commercial Validation LotsCOMMERCIAL RE-VALIDATION DUE TO MAJOR CHANGE DevelopmentStageScope of Product DevelopmentStage 23P r o c e s s R e-v a l i d a t i o nFormula Change Revalidate procedure with new formula process orequipment withProcess Change a different operating principleEquipment ChangeMinor change Follow SUPAC Rules Level I II or III。

HPLC法测定醋酸曲普瑞林微球的载药量及包封率

HPLC法测定醋酸曲普瑞林微球的载药量及包封率

H P L C法测定醋酸曲普瑞林微球的载药量及包封率刘智慧,赵冰,王燕清,徐朋,戈芸芸,苏日佳•(丽珠医药集团股份有限公司,广东珠海519090 )摘要:目的建立H P L C法测定醋酸曲普瑞林微球的栽药量和包封率的方法。

方法色谱柱为P h e n o m e n e x K in etex®E V O C,8 (150 m m x4.6 m m,5 g m);流动相为0.05 m o l.L/1磷酸溶液(用三乙胺调节p H值至3.5)-乙腈(78:22);柱温35 流速为1.0 m L.m iiT1;检测波长为220 n m。

结果空白溶剂、空白微球及供试品溶液中其他杂质色谱峰对主峰曲普瑞林的测定无干扰,曲普瑞林与前后相邻已知杂质峰分离度大于丨.5;曲普瑞林浓度范围在44.5~133.6 p g.m L—线性良好,相关系数为0.999 9 (n=5);定量限为0.16 g g.m L—1;50%浓度回收率为100.1%, 100%浓度回收率为100.5%, 150%浓度回收率为100.5%, ftSZ)为 0.5%;重复性/«£»为0.8%。

结论高效液相色谱方法准确、可靠、专属性强、耐用,可用于醋酸曲普瑞林缓释微球中药物含量的测定和包封率的测定,为制剂的质量控制提供方法。

关键词:醋酸曲普瑞林;微球;H P L C;栽药量;包封率中图分类号:R917 文献标志码:A文章编号:1674-229X(2021) 05-0370-04D o i:10.12048/j.is s n.1674-229X.2021.05.010HPLC Determination of Drug Loading and Encapsulated Efficiency of Triptorelin Acetate MicrospheresLIU Zhihui,ZHAO Bing,WANG Yanqing,XU Peng,GE Yunyun,SU Rijia*(L it)z o n Pharmaceutical Group Co. ,L td., Zhuhai, Guangdong 519090.China)A B S T R A C T:O B J E C T I V E H P L C m e t h o d to established a H P L C m e t h o d for the d e t ermination of d r u g loading a n d e n c a p sulated efficiency of triptorelin acetate microspheres. M E T H O D S A P h e n o m e n e x K i n e t e x® E V O C,8( 150 m m x4.6 m m,5(x m)c o l u m n w a s a d o p t e d with a m o b i l e p h a s e of 0.05m o l*L~l p h o s p h o r i c acid solution(adjust p H to 3.5 with triethylamine )-acetonitrile( 78:22) .T h e flow rate w a s 1.0 m L* m i n''.T h e detection w a v e l e n g t h w a s set at 220n m a n d the c o l u m n t e m p e r a t u r e w a s35Tl. R E S U L T S T h e bl a n k solvent, b l a n k m i c r o s p h e r e s a n d other impurities in s a m p l e s did not interfere with the determination of triptorelin.The resolutionb e t w e e n triptoreline a n d adjacent impurity p e a k s w e r e m o r e t han 1.5.T h e s t andardcurve of triptorelin w a s at g o o d linear in the r a n g e of44.5-133.6^Jig*mL '.T h e correlation coefficient w a s reach 0.999 9(^=5).T h e quantitation limit w a s 0.16 |X g*m L_l.T h e recovery rate of concentration of 50%w a s100.1%,a n d the recovery rate of concentration of 100%w a s100.5%.T h e recovery rate of concentration of 150%w a s100.5%.A n d RSD w a s0.5%, the RSD of repeatability w a s0.8%.C O N C L U S I O N T h e m e t h o d of H P L C is accurate, reliable, specific a n d durable. It c a n b e u s e d to determ i n a t e the d r u g loading a n d e n c a p s u l a t e d efficiency of triptorelin acetate m i c r o s p h e r e s a n d for quality control of m i c r o s p h e r e s .K E Y W O R D S:triptorelin acetate;m i c r o s p h e r e s;H P L C;d r u g l oading;enc a p s u l a t e d efficiency醋酸曲普瑞林为人工合成的强效促性腺激素 释放激素(gonadotropin-releasing hormone,GnRH)。

ASTM B117盐雾测试标准

ASTM B117盐雾测试标准

Designation:B 117–03Standard Practice forOperating Salt Spray (Fog)Apparatus 1This standard is issued under the fixed designation B 117;the number immediately following the designation indicates the year of original adoption or,in the case of revision,the year of last revision.A number in parentheses indicates the year of last reapproval.A superscript epsilon (e )indicates an editorial change since the last revision or reapproval.This standard has been approved for use by agencies of the Department of Defense.1.Scope1.1This practice covers the apparatus,procedure,and conditions required to create and maintain the salt spray (fog)test environment.Suitable apparatus which may be used is described in Appendix X1.1.2This practice does not prescribe the type of test speci-men or exposure periods to be used for a specific product,nor the interpretation to be given to the results.1.3The values stated in SI units are to be regarded as standard.The inch-pound units in parentheses are provided for information and may be approximate.1.4This standard does not purport to address all of the safety concerns,if any,associated with its use.It is the responsibility of the user of this standard to establish appro-priate safety and health practices and determine the applica-bility of regulatory limitations prior to use.2.Referenced Documents 2.1ASTM Standards:B 368Method for Copper-Accelerated Acetic Acid-Salt Spray (Fog)Testing (CASS Test)2D 609Practice for Preparation of Cold-Rolled Steel Panels for Testing Paint,Varnish,Conversion Coatings,and Related Coating Products 3D 1193Specification for Reagent Water 4D 1654Test Method for Evaluation of Painted or Coated Specimens Subjected to Corrosive Environments 3E 70Test Method for pH of Aqueous Solutions with the Glass Electrode 5E 691Practice for Conducting an Interlaboratory Study to Determine the Precision of a Test Method 6G 85Practice for Modified Salt Spray (Fog)Testing 73.Significance and Use3.1This practice provides a controlled corrosive environ-ment which has been utilized to produce relative corrosion resistance information for specimens of metals and coated metals exposed in a given test chamber.3.2Prediction of performance in natural environments has seldom been correlated with salt spray results when used as stand alone data.3.2.1Correlation and extrapolation of corrosion perfor-mance based on exposure to the test environment provided by this practice are not always predictable.3.2.2Correlation and extrapolation should be considered only in cases where appropriate corroborating long-term atmo-spheric exposures have been conducted.3.3The reproducibility of results in the salt spray exposure is highly dependent on the type of specimens tested and the evaluation criteria selected,as well as the control of the operating variables.In any testing program,sufficient repli-cates should be included to establish the variability of the results.Variability has been observed when similar specimens are tested in different fog chambers even though the testing conditions are nominally similar and within the ranges speci-fied in this practice.4.Apparatus4.1The apparatus required for salt spray (fog)exposure consists of a fog chamber,a salt solution reservoir,a supply of suitably conditioned compressed air,one or more atomizing nozzles,specimen supports,provision for heating the chamber,and necessary means of control.The size and detailed con-struction of the apparatus are optional,provided the conditions obtained meet the requirements of this practice.4.2Drops of solution which accumulate on the ceiling or cover of the chamber shall not be permitted to fall on the specimens being exposed.1This practice is under the jurisdiction of ASTM Committee G01on Corrosion of Metals and is the direct responsibility of Subcommittee G01.05on Laboratory Corrosion Tests.Current edition approved October 1,2003.Published October 2003.Originally approved in st previous edition approved in 2002as B 117–02.2Annual Book of ASTM Standards ,V ol 02.05.3Annual Book of ASTM Standards ,V ol 06.01.4Annual Book of ASTM Standards ,V ol 11.01.5Annual Book of ASTM Standards ,V ol 15.05.6Annual Book of ASTM Standards ,V ol 14.02.7Annual Book of ASTM Standards ,V ol 03.02.1Copyright ©ASTM International,100Barr Harbor Drive,PO Box C700,West Conshohocken,PA 19428-2959,UnitedStates.4.3Drops of solution which fall from the specimens shall not be returned to the solution reservoir for respraying.4.4Material of construction shall be such that it will not affect the corrosiveness of the fog.4.5All water used for this practice shall conform to Type IV water in Specification D1193(except that for this practice limits for chlorides and sodium may be ignored).This does not apply to running tap water.All other water will be referred to as reagent grade.5.Test Specimens5.1The type and number of test specimens to be used,as well as the criteria for the evaluation of the test results,shall be defined in the specifications covering the material or product being exposed or shall be mutually agreed upon between the purchaser and the seller.6.Preparation of Test Specimens6.1Specimens shall be suitably cleaned.The cleaning method shall be optional depending on the nature of the surface and the contaminants.Care shall be taken that specimens are not recontaminated after cleaning by excessive or careless handling.6.2Specimens for the evaluation of paints and other organic coatings shall be prepared in accordance with applicable specification(s)for the material(s)being exposed,or as agreed upon between the purchaser and the supplier.Otherwise,the test specimens shall consist of steel meeting the requirements of Practice D609and shall be cleaned and prepared for coating in accordance with the applicable procedure of Practice D609.6.3Specimens coated with paints or nonmetallic coatings shall not be cleaned or handled excessively prior to test.6.4Whenever it is desired to determine the development of corrosion from an abraded area in the paint or organic coating, a scratch or scribed line shall be made through the coating with a sharp instrument so as to expose the underlying metal before testing.The conditions of making the scratch shall be as defined in Test Method D1654,unless otherwise agreed upon between the purchaser and the seller.6.5Unless otherwise specified,the cut edges of plated, coated,or duplex materials and areas containing identification marks or in contact with the racks or supports shall be protected with a suitable coating stable under the conditions of the practice.N OTE1—Should it be desirable to cut test specimens from parts or from preplated,painted,or otherwise coated steel sheet,the cut edges shall be protected by coating them with paint,wax,tape,or other effective media so that the development of a galvanic effect between such edges and the adjacent plated or otherwise coated metal surfaces,is prevented.7.Position of Specimens During Exposure7.1The position of the specimens in the salt spray chamber during the test shall be such that the following conditions are met:7.1.1Unless otherwise specified,the specimens shall be supported or suspended between15and30°from the vertical and preferably parallel to the principal direction offlow of fog through the chamber,based upon the dominant surface being tested.7.1.2The specimens shall not contact each other or any metallic material or any material capable of acting as a wick.7.1.3Each specimen shall be placed to permit unencum-bered exposure to the fog.7.1.4Salt solution from one specimen shall not drip on any other specimen.N OTE2—Suitable materials for the construction or coating of racks and supports are glass,rubber,plastic,or suitably coated wood.Bare metal shall not be used.Specimens shall preferably be supported from the bottom or the side.Slotted wooden strips are suitable for the support offlat panels.Suspension from glass hooks or waxed string may be used as long as the specified position of the specimens is obtained,if necessary by means of secondary support at the bottom of the specimens.8.Salt Solution8.1The salt solution shall be prepared by dissolving561 parts by mass of sodium chloride in95parts of water conforming to Type IV water in Specification D1193(except that for this practice limits for chlorides and sodium may be ignored).Careful attention should be given to the chemical content of the salt.The salt used shall be sodium chloride with not more than0.3%by mass of total impurities.Halides (Bromide,Fluoride,and Iodide)other than Chloride shall constitute less than0.1%by mass of the salt content.Copper content shall be less than0.3ppm by mass.Sodium chloride containing anti-caking agents shall not be used because such agents may act as corrosion inhibitors.See Table1for a listing of these impurity restrictions.Upon agreement between the purchaser and the seller,analysis may be required and limits established for elements or compounds not specified in the chemical composition given above.TABLE1Maximum Allowable Limits for Impurity Levels inSodium Chloride A,BImpurity Description Allowable Amount Total Impurities#0.3% Halides(Bromide,Fluoride and Iodide)excluding Chloride#0.1% Copper<0.3ppmAnti-caking Agents0.0%A A common formula used to calculate the amount of salt required by mass to achieve a5%salt solution of a known mass of water is:.053X Mass of Water5Mass of NaCl requiredThe mass of water is1g per1mL.To calculate the mass of salt required in grams to mix1L of a5%salt solution,multiply.053by1000g(35.27oz.,the mass of 1L of water).This formula yields a result of53g(1.87oz.)of NaCl required for each liter of water to achieve a5%salt solution by mass.The0.053multiplier for the sodium chloride used above is derived by the following:1000g~mass of a full L of water!divided by0.95~water is only95%of the total mixture by mass!yields1053gThis1053g is the total mass of the mixture of one L of water with a5%sodium chloride concentration.1053g minus the original weight of the L of water,1000g, yields53g for the weight of the sodium chloride.53g of total sodium chloride divided by the original1000g of water yields a0.053multiplier for the sodium chloride.As an example:to mix the equivalent of200L(52.83gal)of5%sodium chloride solution,mix10.6kg(23.37lb)of sodium chloride into200L(52.83gal)of water. 200L of water weighs200,000g.200,000g of water x.053(sodium chloride multiplier)=10,600g of sodium chloride,or10.6kg.B In order to ensure that the proper salt concentration was achieved when mixing the solution,it is recommended that the solution be checked with either a salimeter hydrometer or specific gravity hydrometer.When using a salimeter hydrometer,the measurement should be between4and6%at25°C(77°F).When using a specific gravity hydrometer,the measurement should be between1.0255and1.0400at 25°C(77°F).8.2The pH of the salt solution shall be such that when atomized at35°C(95°F)the collected solution will be in the pH range from6.5to7.2(Note3).Before the solution is atomized it shall be free of suspended solids(Note4).The pH measurement shall be made at25°C(77°F)using a suitable glass pH-sensing electrode,reference electrode,and pH meter system in accordance with Test Method E70.N OTE3—Temperature affects the pH of a salt solution prepared from water saturated with carbon dioxide at room temperature and pH adjust-ment may be made by the following three methods:(1)When the pH of a salt solution is adjusted at room temperature,and atomized at35°C(95°F),the pH of the collected solution will be higher than the original solution due to the loss of carbon dioxide at the higher temperature.When the pH of the salt solution is adjusted at room temperature,it is therefore necessary to adjust it below6.5so the collected solution after atomizing at35°C(95°F)will meet the pH limits of6.5to 7.2.Take about a50-mL sample of the salt solution as prepared at room temperature,boil gently for30s,cool,and determine the pH.When the pH of the salt solution is adjusted to6.5to7.2by this procedure,the pH of the atomized and collected solution at35°C(95°F)will come within this range.(2)Heating the salt solution to boiling and cooling to35°C(95°F)and maintaining it at35°C(95°F)for approximately48h before adjusting the pH produces a solution the pH of which does not materially change when atomized at35°C(95°F).(3)Heating the water from which the salt solution is prepared to35°C (95°F)or above,to expel carbon dioxide,and adjusting the pH of the salt solution within the limits of6.5to7.2produces a solution the pH of which does not materially change when atomized at35°C(95°F).N OTE4—The freshly prepared salt solution may befiltered or decanted before it is placed in the reservoir,or the end of the tube leading from the solution to the atomizer may be covered with a double layer of cheesecloth to prevent plugging of the nozzle.N OTE5—The pH can be adjusted by additions of dilute ACS reagent grade hydrochloric acid or sodium hydroxide solutions.9.Air Supply9.1The compressed air supply to the Air Saturator Tower shall be free of grease,oil,and dirt before use by passing through well-maintainedfilters.(Note6)This air should be maintained at a sufficient pressure at the base of the Air Saturator Tower to meet the suggested pressures of Table2at the top of the Air Saturator Tower.N OTE6—The air supply may be freed from oil and dirt by passing it through a suitable oil/water extractor(that is commercially available)to stop any oil from reaching the Air Saturator Tower.Many oil/water extractors have an expiration indicator,proper preventive maintenance intervals should take these into account.9.2The compressed air supply to the atomizer nozzle or nozzles shall be conditioned by introducing it into the bottom of a towerfillwed with water.A common method of introduc-ing the air is through an air dispersion device(X1.4.1).The level of the water must be maintained automatically to ensure adequate humidification.It is common practice to maintain the temperature in this tower between46and49°C(114–121°F)to offset the cooling effect of expansion to atmospheric pressure during the atomization process.Table2in9.3of this practice shows the temperature,at different pressures,that are com-monly used to offset the cooling effect of expansion to atmospheric pressure.9.3Careful attention should be given to the relationship of tower temperature to pressure since this relationship can have a direct impact to maintaining proper collection rates(Note7). It is preferable to saturate the air at temperatures well above the chamber temperature as insurance of a wet fog as listed in Table2.N OTE7—If the tower is run outside of these suggested temperature and pressure ranges to acheive proper collection rates as described in10.2of this practice,other means of verifying the proper corrosion rate in the chamber should be investigated,such as the use of control specimens (panels of known performance in the test conducted).It is preferred that control panels be provided that bracket the expected test specimen performance.The controls allow for the normalization of test conditions during repeated running of the test and will also allow comparisons of test results from different repeats of the same test.(Refer to Appendix X3, Evaluation of Corrosive Conditions,for mass loss procedures).10.Conditions in the Salt Spray Chamber10.1Temperature—The exposure zone of the salt spray chamber shall be maintained at35+1.1−1.7°C (95+2−3°F).Each set point and its tolerance represents an operational control point for equilibrium conditions at a single location in the cabinet which may not necessarily represent the uniformity of conditions throughout the cabinet.The tempera-ture within the exposure zone of the closed cabinet shall be recorded(Note8)at least twice a day at least7h apart(except on Saturdays,Sundays,and holidays when the salt spray test is not interrupted for exposing,rearranging,or removing test specimens or to check and replenish the solution in the reservoir)N OTE8—A suitable method to record the temperature is by a continu-ous recording device or by a thermometer which can be read from outside the closed cabinet.The recorded temperature must be obtained with the salt spray chamber closed to avoid a false low reading because of wet-bulb effect when the chamber is open.10.2Atomization and Quantity of Fog—Place at least two clean fog collectors per atomizer tower within the exposure zone so that no drops of solution will be collected from the test specimens or any other source.Position the collectors in the proximity of the test specimens,one nearest to any nozzle and the other farthest from all nozzles.A typical arrangement is shown in Fig.1.The fog shall be such that for each80 cm2(12.4in.2)of horizontal collecting area,there will be collected from1.0to2.0mL of solution per hour based on an average run of at least16h(Note9).The sodium chloride concentration of the collected solution shall be561mass% (Notes9-11).The pH of the collected solution shall be6.5to 7.2.The pH measurement shall be made as described in8.2 (Note3).N OTE9—Suitable collecting devices are glass or plastic funnels with TABLE2Suggested Temperature and Pressure guideline for the top of the Air Saturator Tower for the operation of a test at35°C(95°F)Air Pressure,kPa Temperature,°C Air Pressure,PSI Temperature,°F 83461211496471411711048161191244918121the stems inserted through stoppers into graduated cylinders,or crystal-lizing dishes.Funnels and dishes with a diameter of 10cm (3.94in.)have an area of about 80cm 2(12.4in.2).N OTE 10—A solution having a specific gravity of 1.0255to 1.0400at 25°C (77°F)will meet the concentration requirement.The sodium chloride concentration may also be determined using a suitable salinity meter (for example,utilizing a sodium ion-selective glass electrode)or colorimetrically as follows.Dilute 5mL of the collected solution to 100mL with distilled water and mix thoroughly;pipet a 10-mL aliquot into an evaporating dish or casserole;add 40mL of distilled water and 1mL of 1%potassium chromate solution (chloride-free)and titrate with 0.1N silver nitrate solution to the first appearance of a permanent red coloration.A solution that requires between 3.4and 5.1mL of 0.1N silver nitrate solution will meet the concentration requirements.N OTE 11—Salt solutions from 2to 6%will give the same results,though for uniformity the limits are set at 4to 6%.10.3The nozzle or nozzles shall be so directed or baffled that none of the spray can impinge directly on the test specimens.11.Continuity of Exposure11.1Unless otherwise specified in the specifications cover-ing the material or product being tested,the test shall be continuous for the duration of the entire test period.Continu-ous operation implies that the chamber be closed and the spray operating continuously except for the short daily interruptions necessary to inspect,rearrange,or remove test specimens,to check and replenish the solution in the reservoir,and to make necessary recordings as described in Section 10.Operations shall be so scheduled that these interruptions are held to a minimum.12.Period of Exposure12.1The period of exposure shall be as designated by the specifications covering the material or product being tested or as mutually agreed upon between the purchaser and the seller.N OTE 12—Recommended exposure periods are to be as agreed upon between the purchaser and the seller,but exposure periods of multiples of 24h are suggested.13.Cleaning of Tested Specimens13.1Unless otherwise specified in the specifications cover-ing the material or product being tested,specimens shall be treated as follows at the end of the test:13.1.1The specimens shall be carefully removed.13.2Specimens may be gently washed or dipped in clean running water not warmer than 38°C (100°F)to remove salt deposits from their surface,and then immediately dried.14.Evaluation of Results14.1A careful and immediate examination shall be made as required by the specifications covering the material or product being tested or by agreement between the purchaser and the seller.15.Records and Reports15.1The following information shall be recorded,unless otherwise prescribed in the specifications covering the material or product being tested:15.1.1Type of salt and water used in preparing the salt solution,15.1.2All readings of temperature within the exposure zone of the chamber,15.1.3Daily records of data obtained from each fog-collecting device including the following:15.1.3.1V olume of salt solution collected in millilitres per hour per 80cm 2(12.4in.2),15.1.3.2Concentration or specific gravity at 35°C (95°F)of solution collected,and15.1.3.3pH of collectedsolution.N OTE —This figure shows a typical fog collector arrangement for a single atomizer tower cabinet.The same fog collector arrangement is also applicable for multiple atomizer tower and horizontal (“T”type)atomizer tower cabinet constructions as well.FIG.1Arrangement of FogCollectors15.2Type of specimen and its dimensions,or number or description of part,15.3Method of cleaning specimens before and after testing, 15.4Method of supporting or suspending article in the salt spray chamber,15.5Description of protection used as required in6.5, 15.6Exposure period,15.7Interruptions in exposure,cause,and length of time, and15.8Results of all inspections.N OTE13—If any of the atomized salt solution which has not contacted the test specimens is returned to the reservoir,it is advisable to record the concentration or specific gravity of this solution also.16.Keywords16.1controlled corrosive environment;corrosive condi-tions;determining mass loss;salt spray(fog)exposureAPPENDIXES(Nonmandatory Information)X1.CONSTRUCTION OF APPARATUSX1.1CabinetsX1.1.1Standard salt spray cabinets are available from several suppliers,but certain pertinent accessories are required before they will function according to this practice and provide consistent control for duplication of results.X1.1.2The salt spray cabinet consists of the basic chamber, an air-saturator tower,a salt solution reservoir,atomizing nozzles,specimen supports,provisions for heating the cham-ber,and suitable controls for maintaining the desired tempera-ture.X1.1.3Accessories such as a suitable adjustable baffle or central fog tower,automatic level control for the salt reservoir, and automatic level control for the air-saturator tower are pertinent parts of the apparatus.X1.1.4The size and shape of the cabinet shall be such that the atomization and quantity of collected solution is within the limits of this practice.X1.1.5The chamber shall be made of suitably inert mate-rials such as plastic,glass,or stone,or constructed of metal and lined with impervious plastics,rubber,or epoxy-type materials or equivalent.X1.1.6All piping that contacts the salt solution or spray should be of inert materials such as plastic.Vent piping should be of sufficient size so that a minimum of back pressure exists and should be installed so that no solution is trapped.The exposed end of the vent pipe should be shielded from extreme air currents that may causefluctuation of pressure or vacuum in the cabinet.X1.2Temperature ControlX1.2.1The maintenance of temperature within the salt chamber can be accomplished by several methods.It is generally desirable to control the temperature of the surround-ings of the salt spray chamber and to maintain it as stable as possible.This may be accomplished by placing the apparatus in a constant-temperature room,but may also be achieved by surrounding the basic chamber of a jacket containing water or air at a controlled temperature.X1.2.2The use of immersion heaters in an internal salt solution reservoir or within the chamber is detrimental where heat losses are appreciable because of solution evaporation and radiant heat on the specimens.X1.3Spray NozzlesX1.3.1Satisfactory nozzles may be made of hard rubber, plastic,or other inert materials.The most commonly used type is made of plastic.Nozzles calibrated for air consumption and solution-atomized are available.The operating characteristics of a typical nozzle are given in Table X1.1.X1.3.2It can readily be seen that air consumption is relatively stable at the pressures normally used,but a marked reduction in solution sprayed occurs if the level of the solution is allowed to drop appreciably during the test.Thus,the level of the solution in the salt reservoir must be maintained automatically to ensure uniform fog delivery during the test.8 X1.3.3If the nozzle selected does not atomize the salt solution into uniform droplets,it will be necessary to direct the spray at a baffle or wall to pick up the larger drops and prevent them from impinging on the test specimens.Pending a com-plete understanding of air-pressure effects,and so forth,it is important that the nozzle selected shall produce the desired 8A suitable device for maintaining the level of liquid in either the saturator tower or reservoir of test solution may be designed by a local engineering group,or may be purchased from manufacturers of test cabinets as an accessory.TABLE X1.1Operating Characteristics of Typical Spray Nozzle SiphonHeight,cmAir Flow,dm3/min Solution Consumption,cm3/hAir Pressure,kPa Air Pressure,kPa34691031383469103138 101926.531.5362100384045845256 201926.531.536636276037204320 301926.531.5360138030003710 401926.631.536078021242904SiphonHeight,in.Air Flow,L/minSolutionConsumption,mL/hAir Pressure,psi Air Pressure,psi51015205101520 41926.531.5362100384045845256 81926.531.536636276037204320 121926.531.5360138030003710 161926.631.536078021242904condition when operated at the air pressure selected.Nozzles are not necessarily located at one end,but may be placed in the center and can also be directed vertically up through a suitable tower.X1.4Air for AtomizationX1.4.1The air used for atomization must be free of grease, oil,and dirt before use by passing through well-maintainedfilters.Room air may be compressed,heated,humidified,and washed in a water-sealed rotary pump if the temperature of the water is suitably controlled.Otherwise cleaned air may be introduced into the bottom of a towerfilled with water through a porous stone or multiple nozzles.The level of the water must be maintained automatically to ensure adequate humidification.A chamber operated in accordance with this method and Appendix X1will have a relative humidity between95and 98%.Since salt solutions from2to6%will give the same results(though for uniformity the limits are set at4to6%),it is preferable to saturate the air at temperatures well above the chamber temperature as insurance of a wet fog.Table X1.2 shows the temperatures,at different pressures,that are required to offset the cooling effect of expansion to atmospheric pressure.X1.4.2Experience has shown that most uniform spray chamber atmospheres are obtained by increasing the atomizing air temperature sufficiently to offset heat losses,except those that can be replaced otherwise at very low-temperature gradi-ents.X1.5Types of ConstructionX1.5.1A modern laboratory cabinet is shown in Fig.X1.1. Walk-in chambers are usually constructed with a sloping ceiling.Suitably located and directed spray nozzles avoid ceiling accumulation and drip.Nozzles may be located at the ceiling,or0.91m(3ft)from thefloor directed upward at30to 60°over a passageway.The number of nozzles depends on type and capacity and is related to the area of the test space.An11 to19L(3to5-gal)reservoir is required within the chamber, with the level controlled.The major features of a walk-in type cabinet,which differs significantly from the laboratory type, are illustrated in Fig.X1.2.Construction of a plastic nozzle, such as is furnished by several suppliers,is shown in Fig.X1.3.TABLE X1.2Temperature and Pressure Requirements forOperation of Test at95°FAir Pressure,kPa8396110124 Temperature,°C46474849Air Pressure,psi12141618 Temperature,°F114117119121。

correlation 标准流程

correlation 标准流程

correlation 标准流程英文回答:Correlation.Correlation is a statistical measure that expresses the extent to which two variables are linearly related. It is a value between -1 and 1, where -1 indicates a perfect negative correlation, 0 indicates no correlation, and 1 indicates a perfect positive correlation.The correlation coefficient is calculated by dividing the covariance of the two variables by the product of their standard deviations. The covariance is a measure of how much the two variables vary together, and the standard deviation is a measure of how much each variable varies on its own.Correlation is a useful tool for understanding the relationship between two variables. It can be used toidentify trends, make predictions, and test hypotheses. However, it is important to note that correlation does not imply causation. Just because two variables are correlated does not mean that one causes the other.Types of Correlation.There are three main types of correlation:Positive correlation: This type of correlation occurs when two variables increase or decrease together. For example, the number of hours you study for a test and your score on the test are positively correlated.Negative correlation: This type of correlation occurs when one variable increases and the other variable decreases. For example, the amount of money you spend ongas and your car's gas mileage are negatively correlated.No correlation: This type of correlation occurs when there is no relationship between two variables. For example, the number of times you flip a coin and the number of headsyou get are not correlated.Strength of Correlation.The strength of a correlation is determined by the absolute value of the correlation coefficient. The closer the correlation coefficient is to 1 or -1, the stronger the correlation. A correlation coefficient of 0 indicates that there is no correlation between the two variables.Significance of Correlation.The significance of a correlation is determined by the p-value. The p-value is the probability of obtaining a correlation coefficient as large as or larger than the one that was observed, assuming that there is no correlation between the two variables. A p-value less than 0.05 is considered to be statistically significant.Correlation Analysis.Correlation analysis is a statistical technique that isused to identify and measure the relationship between two or more variables. Correlation analysis can be used to:Identify trends.Make predictions.Test hypotheses.Control for confounding variables.Correlation analysis is a valuable tool for understanding the relationships between variables. However, it is important to note that correlation does not imply causation.中文回答:相关性。

Correlation

Correlation

究, 考虑两个变量之间的联合变动,而且这两个变量都不受实验者 的限制。
相关系数r (Sample Coefficient of Correlation): also known as
Pearson’s Product Moment, A measure of how well one variable is explained by another. The sign of r indicates the direction of the relationship between X and Y. 相关决定系数r2 (Sample Coefficient of Determination):A measure of the strength of a linear relationship between two variables. For example a correlation between X and Y variables with r2 = 0.90 means that 90% of the change in Y variable are explained by the line of the regression. 计算方法:
0.0780 0.0775 0.0770 0.0765 0.0760 0.0755 0.0750 0.0745 0.0740 0.0735 0.0730 0.0725 0.07300 y = 0.9289x + 0.0045 R2 = 0.9651
0.07400
0.07500
0.07600
0.07700
Solution : Stratify data by group, machine, process, etc.

高效液相色谱法测定糕点中的柠檬黄、日落黄

高效液相色谱法测定糕点中的柠檬黄、日落黄

高效液相色谱法测定糕点中的柠檬黄、日落黄刘芳【摘要】The method for determination of lemon yellow and sunset yellow in pastry by high performance liquid chromatography was established. Samples was extracted by water immersion, and mixed rapidly by vortex mixer, and than soaked overnight. After taking centrifugal supernatant, lemon yellow and sunset yellow were determined with gradient elution of methanol and ammonium acetate solution by UV detector at 430 nm and 482 nm, respectively. The linear correlation coefficient was 0.999, and the detection limit of lemon yellow and sunset yellow was 0.4 and 0.3 mg/kg, respectively. The recovery was 72.5%-82.0%,and the relative standard deviation of determination results was 4.8%and 3.7%(n=5) for lemon yellow and sunset yellow. This method is simple and quick approach with less reagent,reducing the impurity interference and increasing the sensitivity at the same time.%建立高效液相色谱法测定糕点中的柠檬黄、日落黄的方法。

近藤效应

近藤效应

Tunable Kondo effect in a single donor atomnsbergen 1,G.C.Tettamanzi 1,J.Verduijn 1,N.Collaert 2,S.Biesemans 2,M.Blaauboer 1,and S.Rogge 11Kavli Institute of Nanoscience,Delft University of Technology,Lorentzweg 1,2628CJ Delft,The Netherlands and2InterUniversity Microelectronics Center (IMEC),Kapeldreef 75,3001Leuven,Belgium(Dated:September 30,2009)The Kondo effect has been observed in a single gate-tunable atom.The measurement device consists of a single As dopant incorporated in a Silicon nanostructure.The atomic orbitals of the dopant are tunable by the gate electric field.When they are tuned such that the ground state of the atomic system becomes a (nearly)degenerate superposition of two of the Silicon valleys,an exotic and hitherto unobserved valley Kondo effect appears.Together with the “regular”spin Kondo,the tunable valley Kondo effect allows for reversible electrical control over the symmetry of the Kondo ground state from an SU(2)-to an SU(4)-configuration.The addition of magnetic impurities to a metal leads to an anomalous increase of their resistance at low tem-perature.Although discovered in the 1930’s,it took until the 1960’s before this observation was satisfactorily ex-plained in the context of exchange interaction between the localized spin of the magnetic impurity and the de-localized conduction electrons in the metal [1].This so-called Kondo effect is now one of the most widely stud-ied phenomena in condensed-matter physics [2]and plays a mayor role in the field of nanotechnology.Kondo ef-fects on single atoms have first been observed by STM-spectroscopy and were later discovered in a variety of mesoscopic devices ranging from quantum dots and car-bon nanotubes to single molecules [3].Kondo effects,however,do not only arise from local-ized spins:in principle,the role of the electron spin can be replaced by another degree of freedom,for example or-bital momentum [4].The simultaneous presence of both a spin-and an orbital degeneracy gives rise to an exotic SU(4)-Kondo effect,where ”SU(4)”refers to the sym-metry of the corresponding Kondo ground state [5,6].SU(4)Kondo effects have received quite a lot of theoret-ical attention [6,7],but so far little experimental work exists [8].The atomic orbitals of a gated donor in Si consist of linear combinations of the sixfold degenerate valleys of the Si conduction band.The orbital-(or more specifi-cally valley)-degeneracy of the atomic ground state is tunable by the gate electric field.The valley splitting ranges from ∼1meV at high fields (where the electron is pulled towards the gate interface)to being equal to the donors valley-orbit splitting (∼10-20meV)at low fields [9,10].This tunability essentially originates from a gate-induced quantum confinement transition [10],namely from Coulombic confinement at the donor site to 2D-confinement at the gate interface.In this article we study Kondo effects on a novel exper-imental system,a single donor atom in a Silicon nano-MOSFET.The charge state of this single dopant can be tuned by the gate electrode such that a single electron (spin)is localized on the pared to quantum dots (or artificial atoms)in Silicon [11,12,13],gated dopants have a large charging energy compared to the level spac-ing due to their typically much smaller size.As a result,the orbital degree of freedom of the atom starts to play an important role in the Kondo interaction.As we will argue in this article,at high gate field,where a (near)de-generacy is created,the valley index forms a good quan-tum number and Valley Kondo [14]effects,which have not been observed before,appear.Moreover,the Valley Kondo resonance in a gated donor can be switched on and offby the gate electrode,which provides for an electri-cally controllable quantum phase transition [15]between the regular SU(2)spin-and the SU(4)-Kondo ground states.In our experiment we use wrap-around gate (FinFET)devices,see Fig.1(a),with a single Arsenic donor in the channel dominating the sub-threshold transport charac-teristics [16].Several recent experiments have shown that the fingerprint of a single dopant can be identified in low-temperature transport through small CMOS devices [16,17,18].We perform transport spectroscopy (at 4K)on a large ensemble of FinFET devices and select the few that show this fingerprint,which essentially consists of a pair of characteristic transport resonances associ-ated with the one-electron (D 0)-and two-electron (D −)-charge states of the single donor [16].From previous research we know that the valley splitting in our Fin-FET devices is typically on the order of a few meV’s.In this Report,we present several such devices that are in addition characterized by strong tunnel coupling to the source/drain contacts which allows for sufficient ex-change processes between the metallic contacts and the atom to observe Kondo effects.Fig.1b shows a zero bias differential conductance (dI SD /dV SD )trace at 4.2K as a function of gate volt-age (V G )of one of the strongly coupled FinFETs (J17).At the V G such that a donor level in the barrier is aligned with the Fermi energy in the source-drain con-tacts (E F ),electrons can tunnel via the level from source to drain (and vice versa)and we observe an increase in the dI SD /dV SD .The conductance peaks indicated bya r X i v :0909.5602v 1 [c o n d -m a t .m e s -h a l l ] 30 S e p 2009FIG.1:Coulomb blocked transport through a single donor in FinFET devices(a)Colored Scanning Electron Micrograph of a typical FinFET device.(b)Differential conductance (dI SD/dV SD)versus gate voltage at V SD=0.(D0)and(D−) indicate respectively the transport resonances of the one-and two-electron state of a single As donor located in the Fin-FET channel.Inset:Band diagram of the FinFET along the x-axis,with the(D0)charge state on resonance.(c)and(d) Colormap of the differential conductance(dI SD/dV SD)as a function of V SD and V G of samples J17and H64.The red dots indicate the(D0)resonances and data were taken at1.6 K.All the features inside the Coulomb diamonds are due to second-order chargefluctuations(see text).(D0)and(D−)are the transport resonances via the one-electron and two-electron charge states respectively.At high gate voltages(V G>450mV),the conduction band in the channel is pushed below E F and the FET channel starts to open.The D−resonance has a peculiar double peak shape which we attribute to capacitive coupling of the D−state to surrounding As atoms[19].The current between the D0and the D−charge state is suppressed by Coulomb blockade.The dI SD/dV SD around the(D0)and(D−)resonances of sample J17and sample H64are depicted in Fig.1c and Fig.1d respectively.The red dots indicate the po-sitions of the(D0)resonance and the solid black lines crossing the red dots mark the outline of its conducting region.Sample J17shows afirst excited state at inside the conducting region(+/-2mV),indicated by a solid black line,associated with the valley splitting(∆=2 mV)of the ground state[10].The black dashed lines indicate V SD=0.Inside the Coulomb diamond there is one electron localized on the single As donor and all the observable transport in this regionfinds its origin in second-order exchange processes,i.e.transport via a vir-tual state of the As atom.Sample J17exhibits three clear resonances(indicated by the dashed and dashed-dotted black lines)starting from the(D0)conducting region and running through the Coulomb diamond at-2,0and2mV. The-2mV and2mV resonances are due to a second or-der transition where an electron from the source enters one valley state,an the donor-bound electron leaves from another valley state(see Fig.2(b)).The zero bias reso-nance,however,is typically associated with spin Kondo effects,which happen within the same valley state.In sample H64,the pattern of the resonances looks much more complicated.We observe a resonance around0mV and(interrupted)resonances that shift in V SD as a func-tion of V G,indicating a gradual change of the internal level spectrum as a function of V G.We see a large in-crease in conductance where one of the resonances crosses V SD=0(at V G∼445mV,indicated by the red dashed elipsoid).Here the ground state has a full valley degen-eracy,as we will show in thefinal paragraph.There is a similar feature in sample J17at V G∼414mV in Fig.1c (see also the red cross in Fig.1b),although that is prob-ably related to a nearby defect.Because of the relative simplicity of its differential conductance pattern,we will mainly use data obtained from sample J17.In order to investigate the behavior at the degeneracy point of two valley states we use sample H64.In the following paragraphs we investigate the second-order transport in more detail,in particular its temper-ature dependence,fine-structure,magneticfield depen-dence and dependence on∆.We start by analyzing the temperature(T)dependence of sample J17.Fig.2a shows dI SD/dV SD as a function of V SD inside the Coulomb diamond(at V G=395mV) for a range of temperatures.As can be readily observed from Fig.2a,both the zero bias resonance and the two resonances at V SD=+/-∆mV are suppressed with increasing T.The inset of Fig.2a shows the maxima (dI/dV)MAX of the-2mV and0mV resonances as a function of T.We observe a logarithmic dependence on T(a hallmark sign of Kondo correlations)at both resonances,as indicated by the red line.To investigate this point further we analyze another sample(H67)which has sharper resonances and of which more temperature-dependent data were obtained,see Fig.2c.This sample also exhibits the three resonances,now at∼-1,0and +1mV,and the same strong suppression by tempera-ture.A linear background was removed for clarity.We extracted the(dI/dV)MAX of all three resonances forFIG.2:Electrical transport through a single donor atom in the Coulomb blocked region(a)Differential conductance of sample J17as a function of V SD in the Kondo regime(at V G=395mV).For clarity,the temperature traces have been offset by50nS with respect to each other.Both the resonances with-and without valley-stateflip scale similarly with increasing temperature. Inset:Conductance maxima of the resonances at V SD=-2mV and0mV as a function of temperature.(b)Schematic depiction of three(out of several)second-order processes underlying the zero bias and±∆resonances.(c)Differential conductance of sample H67as a function of V SD in the Kondo regime between0.3K and6K.A linear(and temperature independent) background on the order of1µS was removed and the traces have been offset by90nS with respect to each other for clarity.(d)The conductance maxima of the three resonances of(c)normalized to their0.3K value.The red line is afit of the data by Eq.1.all temperatures and normalized them to their respective(dI/dV)MAX at300mK.The result is plotted in Fig.2d.We again observe that all three peaks have the same(log-arithmic)dependence on temperature.This dependenceis described well by the following phenomenological rela-tionship[20](dI SD/dV SD)max (T)=(dI SD/dV SD)T 2KT2+TKs+g0(1)where TK =T K/√21/s−1,(dI SD/dV SD)is the zero-temperature conductance,s is a constant equal to0.22 [21]and g0is a constant.Here T K is the Kondo tem-perature.The red curve in Fig.2d is afit of Eq.(1)to the data.We readily observe that the datafit well and extract a T K of2.7K.The temperature scaling demon-strates that both the no valley-stateflip resonance at zero bias voltage and the valley-stateflip-resonance atfinite bias are due to Kondo-type processes.Although a few examples offinite-bias Kondo have been reported[15,22,23],the corresponding resonances (such as our±∆resonances)are typically associated with in-elastic cotunneling.Afinite bias between the leads breaks the coherence due to dissipative transitions in which electrons are transmitted from the high-potential-lead to the low-potential lead[24].These dissipative4transitions limit the lifetime of the Kondo-type processes and,if strong enough,would only allow for in-elastic events.In the supporting online text we estimate the Kondo lifetime in our system and show it is large enough to sustain thefinite-bias Kondo effects.The Kondo nature of the+/-∆mV resonances points strongly towards a Valley Kondo effect[14],where co-herent(second-order)exchange between the delocalized electrons in the contacts and the localized electron on the dopant forms a many-body singlet state that screens the valley index.Together with the more familiar spin Kondo effect,where a many-body state screens the spin index, this leads to an SU(4)-Kondo effect,where the spin and charge degree of freedom are fully entangled[8].The ob-served scaling of the+/-∆-and zero bias-resonances in our samples by a single T K is an indication that such a fourfold degenerate SU(4)-Kondo ground state has been formed.To investigate the Kondo nature of the transport fur-ther,we analyze the substructure of the resonances of sample J17,see Fig.2a.The central resonance and the V SD=-2mV each consist of three separate peaks.A sim-ilar substructure can be observed in sample H67,albeit less clear(see Fig.2c).The substructure can be explained in the context of SU(4)-Kondo in combination with a small difference between the coupling of the ground state (ΓGS)-and thefirst excited state(ΓE1)-to the leads.It has been theoretically predicted that even a small asym-metry(ϕ≡ΓE1/ΓGS∼=1)splits the Valley Kondo den-sity of states into an SU(2)-and an SU(4)-part[25].Thiswill cause both the valley-stateflip-and the no valley-stateflip resonances to split in three,where the middle peak is the SU(2)-part and the side-peaks are the SU(4)-parts.A more detailed description of the substructure can be found in the supporting online text.The split-ting between middle and side-peaks should be roughly on the order of T K[25].The measured splitting between the SU(2)-and SU(4)-parts equals about0.5meV for sample J17and0.25meV for sample H67,which thus corresponds to T K∼=6K and T K∼=3K respectively,for the latter in line with the Kondo temperature obtained from the temperature dependence.We further note that dI SD/dV SD is smaller than what we would expect for the Kondo conductance at T<T K.However,the only other study of the Kondo effect in Silicon where T K could be determined showed a similar magnitude of the Kondo signal[12].The presence of this substructure in both the valley-stateflip-,and the no valley-stateflip-Kondo resonance thus also points at a Valley Kondo effect.As a third step,we turn our attention to the magnetic field(B)dependence of the resonances.Fig.3shows a colormap plot of dI SD/dV SD for samples J17and H64 both as a function of V SD and B at300mK.The traces were again taken within the Coulomb diamond.Atfinite magneticfield,the central Kondo resonances of both de-vices split in two with a splitting of2.2-2.4mV at B=FIG.3:Colormap plot of the conductance as a function of V SD and B of sample J17at V G=395mV(a)and H64at V G=464mV(b).The central Kondo resonances split in two lines which are separated by2g∗µB B.The resonances with a valley-stateflip do not seem to split in magneticfield,a feature we associate with the different decay-time of parallel and anti-parallel spin-configurations of the doubly-occupied virtual state(see text).10T.From theoretical considerations we expect the cen-tral Valley Kondo resonance to split in two by∆B= 2g∗µB B if there is no mixing of valley index(this typical 2g∗µB B-splitting of the resonances is one of the hall-marks of the Kondo effect[24]),and to split in three (each separated by g∗µB B)if there is a certain degree of valley index mixing[14].Here,g∗is the g-factor(1.998 for As in Si)andµB is the Bohr magneton.In the case of full mixing of valley index,the valley Kondo effect is expected to vanish and only spin Kondo will remain [25].By comparing our measured magneticfield splitting (∆B)with2g∗µB B,wefind a g-factor between2.1and 2.4for all three devices.This is comparable to the result of Klein et al.who found a g-factor for electrons in SiGe quantum dots in the Kondo regime of around2.2-2.3[13]. The magneticfield dependence of the central resonance5indicates that there is no significant mixing of valley in-dex.This is an important observation as the occurrence of Valley Kondo in Si depends on the absence of mix-ing(and thus the valley index being a good quantum number in the process).The conservation of valley in-dex can be attributed to the symmetry of our system. The large2D-confinement provided by the electricfield gives strong reason to believe that the ground-andfirst excited-states,E GS and E1,consist of(linear combi-nations of)the k=(0,0,±kz)valleys(with z in the electricfield direction)[10,26].As momentum perpen-dicular to the tunneling direction(k x,see Fig.1)is con-served,also valley index is conserved in tunneling[27]. The k=(0,0,±k z)-nature of E GS and E1should be as-sociated with the absence of significant exchange interac-tion between the two states which puts them in the non-interacting limit,and thus not in the correlated Heitler-London limit where singlets and triplets are formed.We further observe that the Valley Kondo resonances with a valley-stateflip do not split in magneticfield,see Fig.3.This behavior is seen in both samples,as indicated by the black straight solid lines,and is most easily ob-served in sample J17.These valley-stateflip resonances are associated with different processes based on their evo-lution with magneticfield.The processes which involve both a valleyflip and a spinflip are expected to shift to energies±∆±g∗µB B,while those without a spin-flip stay at energies±∆[14,25].We only seem to observe the resonances at±∆,i.e.the valley-stateflip resonances without spinflip.In Ref[8],the processes with both an orbital and a spinflip also could not be observed.The authors attribute this to the broadening of the orbital-flip resonances.Here,we attribute the absence of the processes with spinflip to the difference in life-time be-tween the virtual valley state where two spins in seperate valleys are parallel(τ↑↑)and the virtual state where two spins in seperate valleys are anti-parallel(τ↑↓).In con-trast to the latter,in the parallel spin configuration the electron occupying the valley state with energy E1,can-not decay to the other valley state at E GS due to Pauli spin blockade.It wouldfirst needs toflip its spin[28].We have estimatedτ↑↑andτ↑↓in our system(see supporting online text)andfind thatτ↑↑>>h/k b T K>τ↑↓,where h/k b T K is the characteristic time-scale of the Kondo pro-cesses.Thus,the antiparallel spin configuration will have relaxed before it has a change to build up a Kondo res-onance.Based on these lifetimes,we do not expect to observe the Kondo resonances associated with both an valley-state-and a spin-flip.Finally,we investigate the degeneracy point of valley states in the Coulomb diamond of sample H64.This degeneracy point is indicated in Fig.1d by the red dashed ellipsoid.By means of the gate electrode,we can tune our system onto-or offthis degeneracy point.The gate-tunability in this sample is created by a reconfiguration of the level spectrum between the D0and D−-charge states,FIG.4:Colormap plot of I SD at V SD=0as a function of V G and B.For increasing B,a conductance peak develops around V G∼450mV at the valley degeneracy point(∆= 0),indicated by the dashed black line.Inset:Magneticfield dependence of the valley degeneracy point.The resonance is fixed at zero bias and its magnitude does not depend on the magneticfield.probably due to Coulomb interactions in the D−-states. Figure4shows a colormap plot of I SD at V SD=0as a function of V G and B(at0.3K).Note that we are thus looking at the current associated with the central Kondo resonance.At B=0,we observe an increasing I SD for higher V G as the atom’s D−-level is pushed toward E F. As B is increased,the central Kondo resonance splits and moves away from V SD=0,see Fig.3.This leads to a general decrease in I SD.However,at around V G= 450mV a peak in I SD develops,indicated by the dashed black line.The applied B-field splits offthe resonances with spin-flip,but it is the valley Kondo resonance here that stays at zero bias voltage giving rise to the local current peak.The inset of Fig.4shows the single Kondo resonance in dI SD/dV SD as a function of V SD and B.We observe that the magnitude of the resonance does not decrease significantly with magneticfield in contrast to the situation at∆=0(Fig.3b).This insensitivity of the Kondo effect to magneticfield which occurs only at∆= 0indicates the profound role of valley Kondo processes in our structure.It is noteworthy to mention that at this specific combination of V SD and V G the device can potentially work as a spin-filter[6].We acknowledge fruitful discussions with Yu.V. Nazarov,R.Joynt and S.Shiau.This project is sup-ported by the Dutch Foundation for Fundamental Re-search on Matter(FOM).6[1]Kondo,J.,Resistance Minimum in Dilute Magnetic Al-loys,Prog.Theor.Phys.3237-49(1964)[2]Hewson,A.C.,The Kondo Problem to Heavy Fermions(Cambridge Univ.Press,Cambridge,1993).[3]Wingreen N.S.,The Kondo effect in novel systems,Mat.Science Eng.B842225(2001)and references therein.[4]Cox,D.L.,Zawadowski,A.,Exotic Kondo effects in met-als:magnetic ions in a crystalline electricfield and tun-neling centers,Adv.Phys.47,599-942(1998)[5]Inoshita,T.,Shimizu, A.,Kuramoto,Y.,Sakaki,H.,Correlated electron transport through a quantum dot: the multiple-level effect.Phys.Rev.B48,14725-14728 (1993)[6]Borda,L.Zar´a nd,G.,Hofstetter,W.,Halperin,B.I.andvon Delft,J.,SU(4)Fermi Liquid State and Spin Filter-ing in a Double Quantum Dot System,Phys.Rev.Lett.90,026602(2003)[7]Zar´a nd,G.,Orbitalfluctuations and strong correlationsin quantum dots,Philosophical Magazine,86,2043-2072 (2006)[8]Jarillo-Herrero,P.,Kong,J.,van der Zant H.S.J.,Dekker,C.,Kouwenhoven,L.P.,De Franceschi,S.,Or-bital Kondo effect in carbon nanotubes,Nature434,484 (2005)[9]Martins,A.S.,Capaz,R.B.and Koiller,B.,Electric-fieldcontrol and adiabatic evolution of shallow donor impuri-ties in silicon,Phys.Rev.B69,085320(2004)[10]Lansbergen,G.P.et al.,Gate induced quantum confine-ment transition of a single dopant atom in a Si FinFET, Nature Physics4,656(2008)[11]Rokhinson,L.P.,Guo,L.J.,Chou,S.Y.,Tsui, D.C.,Kondo-like zero-bias anomaly in electronic transport through an ultrasmall Si quantum dot,Phys.Rev.B60, R16319-R16321(1999)[12]Specht,M.,Sanquer,M.,Deleonibus,S.,Gullegan G.,Signature of Kondo effect in silicon quantum dots,Eur.Phys.J.B26,503-508(2002)[13]Klein,L.J.,Savage, D.E.,Eriksson,M.A.,Coulombblockade and Kondo effect in a few-electron silicon/silicon-germanium quantum dot,Appl.Phys.Lett.90,033103(2007)[14]Shiau,S.,Chutia,S.and Joynt,R.,Valley Kondo effectin silicon quantum dots,Phys.Rev.B75,195345(2007) [15]Roch,N.,Florens,S.,Bouchiat,V.,Wernsdirfer,W.,Balestro, F.,Quantum phase transistion in a single molecule quantum dot,Nature453,633(2008)[16]Sellier,H.et al.,Transport Spectroscopy of a SingleDopant in a Gated Silicon Nanowire,Phys.Rev.Lett.97,206805(2006)[17]Calvet,L.E.,Wheeler,R.G.and Reed,M.A.,Observa-tion of the Linear Stark Effect in a Single Acceptor in Si, Phys.Rev.Lett.98,096805(2007)[18]Hofheinz,M.et al.,Individual charge traps in siliconnanowires,Eur.Phys.J.B54,299307(2006)[19]Pierre,M.,Hofheinz,M.,Jehl,X.,Sanquer,M.,Molas,G.,Vinet,M.,Deleonibus S.,Offset charges acting as ex-cited states in quantum dots spectroscopy,Eur.Phys.J.B70,475-481(2009)[20]Goldhaber-Gordon,D.,Gres,J.,Kastner,M.A.,Shtrik-man,H.,Mahalu, D.,Meirav,U.,From the Kondo Regime to the Mixed-Valence Regime in a Single-Electron Transistor,Phys.Rev.Lett.81,5225(1998) [21]Although the value of s=0.22stems from SU(2)spinKondo processes,it is valid for SU(4)-Kondo systems as well[8,25].[22]Paaske,J.,Rosch,A.,W¨o lfle,P.,Mason,N.,Marcus,C.M.,Nyg˙ard,Non-equilibrium singlet-triplet Kondo ef-fect in carbon nanotubes,Nature Physics2,460(2006) [23]Osorio, E.A.et al.,Electronic Excitations of a SingleMolecule Contacted in a Three-Terminal Configuration, Nanoletters7,3336-3342(2007)[24]Meir,Y.,Wingreen,N.S.,Lee,P.A.,Low-TemperatureTransport Through a Quantum Dot:The Anderson Model Out of Equilibrium,Phys.Rev.Lett.70,2601 (1993)[25]Lim,J.S.,Choi,M-S,Choi,M.Y.,L´o pez,R.,Aguado,R.,Kondo effects in carbon nanotubes:From SU(4)to SU(2)symmetry,Phys.Rev.B74,205119(2006) [26]Hada,Y.,Eto,M.,Electronic states in silicon quan-tum dots:Multivalley artificial atoms,Phys.Rev.B68, 155322(2003)[27]Eto,M.,Hada,Y.,Kondo Effect in Silicon QuantumDots with Valley Degeneracy,AIP Conf.Proc.850,1382-1383(2006)[28]A comparable process in the direct transport throughSi/SiGe double dots(Lifetime Enhanced Transport)has been recently proposed[29].[29]Shaji,N.et.al.,Spin blockade and lifetime-enhancedtransport in a few-electron Si/SiGe double quantum dot, Nature Physics4,540(2008)7Supporting InformationFinFET DevicesThe FinFETs used in this study consist of a silicon nanowire connected to large contacts etched in a60nm layer of p-type Silicon On Insulator.The wire is covered with a nitrided oxide(1.4nm equivalent SiO2thickness) and a narrow poly-crystalline silicon wire is deposited perpendicularly on top to form a gate on three faces.Ion implantation over the entire surface forms n-type degen-erate source,drain,and gate electrodes while the channel protected by the gate remains p-type,see Fig.1a of the main article.The conventional operation of this n-p-n field effect transistor is to apply a positive gate voltage to create an inversion in the channel and allow a current toflow.Unintentionally,there are As donors present be-low the Si/SiO2interface that show up in the transport characteristics[1].Relation between∆and T KThe information obtained on T K in the main article allows us to investigate the relation between the splitting (∆)of the ground(E GS)-andfirst excited(E1)-state and T K.It is expected that T K decreases as∆increases, since a high∆freezes out valley-statefluctuations.The relationship between T K of an SU(4)system and∆was calculated by Eto[2]in a poor mans scaling approach ask B T K(∆) B K =k B T K(∆=0)ϕ(2)whereϕ=ΓE1/ΓGS,withΓE1andΓGS the lifetimes of E1and E GS respectively.Due to the small∆com-pared to the barrier height between the atom and the source/drain contact,we expectϕ∼1.Together with ∆=1meV and T K∼2.7K(for sample H67)and∆=2meV and T K∼6K(for sample J17),Eq.2yields k B T K(∆)/k B T K(∆=0)=0.4and k B T K(∆)/k B T K(∆= 0)=0.3respectively.We can thus conclude that the rela-tively high∆,which separates E GS and E1well in energy, will certainly quench valley-statefluctuations to a certain degree but is not expected to reduce T K to a level that Valley effects become obscured.Valley Kondo density of statesHere,we explain in some more detail the relation be-tween the density of states induced by the Kondo effects and the resulting current.The Kondo density of states (DOS)has three main peaks,see Fig.1a.A central peak at E F=0due to processes without valley-stateflip and two peaks at E F=±∆due to processes with valley-state flip,as explained in the main text.Even a small asym-metry(ϕclose to1)will split the Valley Kondo DOS into an SU(2)-and an SU(4)-part[3],indicated in Fig1b in black and red respectively.The SU(2)-part is positioned at E F=0or E F=±∆,while the SU(4)-part will be shifted to slightly higher positive energy(on the order of T K).A voltage bias applied between the source and FIG.1:(a)dI SD/dV SD as a function of V SD in the Kondo regime(at395mV G)of sample J17.The substructure in the Kondo resonances is the result of a small difference between ΓE1andΓGS.This splits the peaks into a(central)SU(2)-part (black arrows)and two SU(4)-peaks(red arrows).(b)Density of states in the channel as a result ofϕ(=ΓE1/ΓGS)<1and applied V SD.drain leads results in the Kondo peaks to split,leaving a copy of the original structure in the DOS now at the E F of each lead,which is schematically indicated in Fig.1b by a separate DOS associated with each contact.The current density depends directly on the density of states present within the bias window defined by source/drain (indicated by the gray area in Fig1b)[4].The splitting between SU(2)-and SU(4)-processes will thus lead to a three-peak structure as a function of V SD.Figure.1a has a few more noteworthy features.The zero-bias resonance is not positioned exactly at V SD=0, as can also be observed in the transport data(Fig1c of the main article)where it is a few hundredµeV above the Fermi energy near the D0charge state and a few hundredµeV below the Fermi energy near the D−charge state.This feature is also known to arise in the Kondo strong coupling limit[5,6].We further observe that the resonances at V SD=+/-2mV differ substantially in magnitude.This asymmetry between the two side-peaks can actually be expected from SU(4)Kondo sys-tems where∆is of the same order as(but of course al-ways smaller than)the energy spacing between E GS and。

关联波动 英语

关联波动 英语

关联波动英语Correlation FluctuationsThe concept of correlation fluctuations is a fundamental aspect of statistical physics and plays a crucial role in understanding the behavior of complex systems. In this essay, we will delve into the intricacies of correlation fluctuations, their significance, and their applications in various fields.Correlation is a statistical measure that quantifies the relationship between two or more variables. It describes the degree to which the variables are linearly related, with a value ranging from -1 to 1. When the variables are perfectly correlated, the correlation coefficient is either 1 (positive correlation) or -1 (negative correlation). In contrast, a correlation coefficient of 0 indicates that the variables are completely uncorrelated.Correlation fluctuations, on the other hand, refer to the variations in the correlation coefficient over time or across different realizations of a system. These fluctuations can arise due to various factors, such as the inherent randomness in the system, the finite size of the system, or the presence of external perturbations.One of the primary reasons why correlation fluctuations are important is their ability to reveal the underlying dynamics and interactions within a complex system. In many physical, biological, and social systems, the correlations between different variables are not constant but rather exhibit fluctuations over time or across different realizations. These fluctuations can provide valuable insights into the system's behavior, the nature of its interactions, and the mechanisms driving its evolution.For example, in the study of financial markets, correlation fluctuations between different asset prices can be used to identify patterns, detect market anomalies, and develop more effective trading strategies. In neuroscience, the study of correlation fluctuations in neural activity can shed light on the functional connectivity and information processing within the brain. In ecology, correlation fluctuations between different species populations can help researchers understand the complex dynamics of ecosystems and the impact of environmental changes.Furthermore, the study of correlation fluctuations has led to the development of powerful theoretical frameworks, such as the theory of critical phenomena and the theory of complex networks. These frameworks have enabled researchers to understand the universal behavior of systems near critical points, where small perturbationscan lead to large-scale changes, and to uncover the collective dynamics of interconnected systems.One of the key concepts in the study of correlation fluctuations is the notion of long-range correlations. In many complex systems, the correlations between different variables exhibit long-range or power-law decay, meaning that the correlations persist over large spatial or temporal scales. The presence of long-range correlations is often a signature of the system's complex and collective behavior, and it can have profound implications for the system's dynamics and response to external perturbations.The study of correlation fluctuations has also been instrumental in the development of new experimental and computational techniques. For instance, the use of advanced statistical methods, such as detrended fluctuation analysis and multifractal analysis, has enabled researchers to quantify and characterize the complex patterns of correlation fluctuations in a wide range of systems. Additionally, the increasing availability of large-scale data and the advancements in computational power have facilitated the analysis of correlation fluctuations in complex systems with unprecedented detail and precision.In conclusion, the study of correlation fluctuations is a vibrant and interdisciplinary field of research that has far-reaching implicationsfor our understanding of complex systems. By unraveling the intricate patterns of correlation fluctuations, researchers can gain valuable insights into the underlying dynamics and interactions that govern the behavior of physical, biological, and social systems. As the field continues to evolve, we can expect to see even more exciting discoveries and advancements that will deepen our understanding of the complex world around us.。

药物分析常用英语词汇

药物分析常用英语词汇

药物分析专业英语词汇表Aabsorbance吸收度absorbanceratio吸收度比值absorption吸收absorptioncurve吸收曲线absorptioncoefficient吸收系数accuratevalue准确值Acid—dyecolormcty酸性染料比色法acidimcty酸量法acidity酸度activity活度adjustedretentiontime调整保留时间absorbent吸收剂absorption吸附alkalinity碱度alumina氧化铝,矾土ambienttemperature室温ammoniumthiocyanate硫氰酸铵analyticalqualitycontrol分析质量控制anhydroussubstance 干燥品antioxidant抗氧剂applicationofsample点样areanormalizationmethod面积归一法arsenic砷arsenicsport砷斑assay含量测定assaytolerance含量限度attenuation衰减acidburette酸式滴定管alkaliburette碱式滴定管amortar研钵Bbackextraction反萃取bandabsorption谱带吸收batch批batchnumber批号Benttendorlfmethod白田道夫法betweendayprecision日间密度精biotransformation生物转化blanktest空白试验boilingrange沸程BritishPharmacopeia英国药典bromatetitration溴酸盐滴定法brominemethod溴量法bromothymolblue溴麝香酚蓝bulkdrug原料药by—product副产物breaker烧杯buretteglassbeadnozzle滴定管brownacidburette棕色酸式滴定管Ccalibrationcurve校正曲线calomelelectrode甘汞电极calorimetry量热分析capacityfactor容量因子capillarygaschromatography毛细管气相色谱法carriergas载气characteristicsdescription性状chelatecompound螯合物chemicalequivalent化学当量Chinesepharmacopeia中国药典Chinesematerialmedicine中成药Chinesematerialmidicalpreparation中药制剂chiral手性的chiralcarbonatom手性碳原子chromatogram色谱图chromatography色谱法chromatographiccolumn色谱柱chromatographiccondition色谱条件clarity澄清度coefficientofdistribution分配系数coefficientofvariation变异系数colorchangeinterval变色范围colorreaction显色反应colormetry比色法columnefficiency柱效columntemperature柱温comparativetest比较试验completenessofsolution溶液的澄清度conjugate缀合物concentration—timecurve浓度时间曲线confidenceinterval置信区间confidencelevel置信水平controlledtrial对照试验correlationcoefficient相关系数contrasttest对照试验congealingpoint凝点contentunifarmity装量差异controlledtrial对照试验correlationcoefficient相关系数contrasttest对照试验counterion反离子cresalred甲酚红cuvettecell比色池cyanide氰化物casserolesmall勺皿Ddead—stoptitration永定滴定法deadtime死时间deflection偏差deflectionpoint拐点degassing脱气deionizedwater去离子水deliquescence潮解depressorsubstancestest降压物质检查法desiccant干燥剂detection检查developingreagent展开剂developingchamber展开室deviation偏差dextrose右旋糖diastereoisomer非对映异构体diazotization重氮化differentialthermalanalysis差示热分析法differentialscanningcalorimetry差示扫描热法Gutzeit古蔡daytodayprecision日间精密度dissolution溶出度directinjection直接进样2,6-dichlorindophenoltitration2,6-二氯靛酚滴定法digestion消化diphastictitration双向滴定disintegrationtest崩解试验dispersion分散度dissolubility溶解度dissolutiontest溶解度检查distillingrange滴程distributionchromatography分配色谱dose剂量drugqualitycontrol药品质量控制dryingtoconstantweight干燥至恒重duplicatetest重复试验diskmethodwatermethod压片法Eeffectiveconstituent有效成分effectiveplatenumber有效板数effectiveofcolumn柱效electrophoresis电泳elimination消除eluate洗脱液elution洗脱enamtiomer对映体endabsorption末端吸收endogenoussubstances内源性物质enzymedrug酶类药物enzymeinduction酶诱导enzymeinhibition酶抑制epimer差向异构体equilibriumconstant平衡常数errorinvolumetricanalysis容量分析误差exclusionchromatography排阻色谱法expirationdate失效期externalstandardmethod外标法extract提取物extrationgravimetry提取重量法extractiontitration提取容量法extrapolatedmethod外插法Erlenmeyerflask锥形瓶evaporatingdishsmall蒸发皿elongatedbulb胖肚electronicbalanceMettlerAL204MettlerAL204电子天平Ffactor系数fehling’sreaction斐林实验filter过滤finenessoftheparticles颗粒细度flowrate流速fluorescentagent荧光剂fluorescencespectrophotometry荧光分光光度法fluorescencedetection荧光检测器fluorescenceanalysis荧光分析法foreignpigment有色杂质formulary处方集free游离freezingtest冻结试验fusedsilica熔融石英filterpaper滤纸Ggaschromatography气相色谱法gas-liquidchromatography气液色谱法gaspurifier气体净化器Generalidentificationtest一般鉴别试验generalnotices凡例Generalrequirements(药典)通则goodclinicalpractices药品临床管理规范goodlaboratorypractices药品实验室管理规范goodmanufacturingpractices(GMP)药品生产质量管理规范goodsupplypractices(GSP)药品供应管理规范gradientelution梯度洗脱grating光栅gravimetricmethod重量法Gutzeittest古蔡(检砷)法glassfunnellongstem玻璃漏斗gradcylinder量筒glassrod玻棒graduatedpipettes刻度吸管GC气相色谱Hheavymetal重金属halfpeakwidth平峰宽heatconductivity热导率heightequivalenttoatheoreticalplate理论塔板高度heightofaneffectiveplate有效塔板高度high-performanceliquidchromatography(HPLC)高效液相色谱法high-performancethin-layerchromatography(HPTLC)高效薄层色谱法hydrate水合物hydrolysis水解hydrophilicity亲水性hydrophobicity疏水性hydroxylvalue羟值hyperchromiceffect浓色效应hypochromiceffect淡色效应HHS-typeconstanttemperaturewaterbathHHS型恒温水锅HPLC高效液相色谱法Iidentification鉴别ignitiontoconstantweight灼烧至恒重immobilephase固定相immunoassay免疫测定impurity杂质inactivation失活index索引indicatorelectrode指示电极indicator指示剂inhibitor抑制剂injectingseptum进样隔膜胶垫instrumentalanalysis仪器分析injectionvalue进样阀insulinassay胰岛素生物检测法integrator积分仪intercept截距interface接口internalstandardsubstance内标物质Internationalunit国际单位invitro体外invivo体内iodide碘化物iodoformreation碘仿反应iodometry碘量法ionpairchromatography离子对色谱ionsuppression离子抑制ionsuppression离子抑制ionicstrength离子强度ion-pairingagent离子对试剂ionization电离isoabsorptivepoint等吸收点isocraticelution等溶剂组成洗脱isoelectricpoint等电点isoosmoticsolution等渗溶液irreversibleindicator不可逆指示剂irreversiblepotential不可逆电位KKarlFischertitration卡尔-费舍尔滴定Kjeldahlmethodfornitrogen凯氏定氮法Koberreagent 科伯试剂Kovatsretentionindex科瓦茨保留指数Llabelledamount标示量leadingpeak前延峰levelingeffect均化效应licensedpharmacist执业药师limitcontrol限量控制limitofdetection检测限limitofquantitation定量限limittest杂质限度试验lossondrying干燥失重lowpressuregradientpump氧压梯度泵linearityandrange线性及范围linearityscanning线性扫描luminescence发光litmuspaper石蕊试纸lyophilization冷冻干燥Mmainconstituent主成分make-upgas尾吹气maltolreaction麦芽酚试验Marquistest马奎斯试验massanalyzerdetector质量分析检测器massspectrometricanalysis质谱分析massspectrum质谱图meandeviation平均偏差meltingpoint熔点meltingrange熔距metabolite代谢物metastableion亚稳离子micellarchromatography胶束色谱法microanalysis微量分析microcrystal微晶microdialysis微透析migrationtime迁移时间Milliporefiltration微孔过滤mobilephase流动相molecularformula分子式monitor检测monochromator单色器monographs正文Nnaturalproduct天然产物Nessler’sreagent碱性碘化汞试液neutralization中和nitrogencontent总氮量nonaqueousacid-basetitration非水酸碱滴定nonprescriptiondrug,overthecounterdrugs非处方药nonspecificimpurity一般杂质non-volatilematter不挥发物normalphase正相normalization归一化法Nesslercolorcomparisontube纳氏比色管Onotice凡例octadecylsilanebondedsilicagel十八烷基硅烷键合硅胶odorless辛基硅烷odorless无臭officialname法定名officialtest法定试验on-columndetector柱上检测器on-columninjection柱头进样onthedriedbasis按干燥品计opalescence乳浊opticalactivity光学活性opticalisomerism旋光异构opticalpurity光学纯度organicvolatileimpurities有机挥发性杂质orthogonaltest正交试验orthophenanthroline邻二氮菲outlier可疑数据overtones倍频封oxidation-reductiontitration氧化还原滴定oxygenflaskcombustion氧瓶燃烧Ppackedcolumn填充柱packingmaterial色谱柱填料palladiumioncolorimetry钯离子比色法parention母离子particulatematter不溶性微粒partitioncoefficient分配系数patternrecognition(ppm)百万分之几peaksymmetry峰不对称性peakvalley峰谷peakwidthathalfheight半峰宽percenttransmittance透光百分率pHindicatorabsorbanceratiomethodpH指示剂吸光度比值法pharmaceuticalanalysis药物分析pharmacopeia药典pharmacy药学photometer光度计polarimetry旋光测定法polarity极性polydextrangel葡聚糖凝胶potentiometer电位计potentiometrictitration电位滴定法precipitationform沉淀形式precision精密度preparation制剂prescriptiondrug处方药pretreatment预处理primarystandard基准物质principalcomponentanalysis主成分分析prototypedrug原型药物purification纯化purity纯度pyrogen热原pycnometermethod比重瓶法plasticwashbottle洗瓶platformbalance天平pipette移液管pyknowmeterflasks容量瓶Qqualitycontrol质量控制qualityevaluation质量评价qualitystandard质量标准quantitativedetermination定量测定quantitativeanalysis定量分析quasi-molecularion准分子离子Rracemization消旋化randomsampling随机抽样rationaluseofdrug合理用药readilycarbonizablesubstance易炭化物质reagentsprayer试剂喷雾剂recovery回收率referenceelectrode参比电极relatedsubstance相关物质relativedensity相对密度relativeintensity相对强度repeatability重复性replicatedetermination平行测定reproducibility重现性residualbasichydrolysismethod剩余碱水解法residualliquidjunctionpotential残余液接电位residualtitration剩余滴定residuceonignition炽灼残渣resolution分辨率responsetime响应时间retention保留reversedphasechromatography反相色谱法reverseosmosis反渗透rinse淋洗robustness可靠性round修约reagentbottles试剂瓶roundbottomflask圆底烧瓶rubbersuctionbulb洗耳球Ssafety安全性Sakaguchitest坂口试验saltbridge盐桥saltingout盐析sampleapplicator点样器sampleapplication点样sampling取样saponificationvalue皂化值saturatedcalomelelectrode饱和甘汞电极selectivity选择性significantdifference显着性水平significanttesting显着性检验silicaget硅胶silverchlorideelectrode氯化银电极similarity相似性sodiumdodecylsulfate十二基酸钠solid-phaseextraction固相萃取solubility溶解度specificabsorbance吸收系数specification规格specificity专属性specificrotation比旋度specificweight比重spiked加入标准的splitinjection分流进样sprayreagent显色剂stability稳定性standardcolorsolution标准比色液standarddeviation标准差standardization标定standardsubstance标准品statisticalerror统计误差sterilitytest无菌试验stocksolution储备液stoichiometricpoint化学计量点storage贮藏straylight杂散光substrate底物substituent取代基sulfate硫酸盐sulphatedash硫酸盐灰分support载体suspension旋浊度swellingdegree膨胀度symmetryfactor对称因子systematicerror系统误差separatingfunnel分液漏斗stopcock玻璃活塞scissors剪刀spiritlamp酒精灯silicagelGthinlayer硅胶G薄层板Ttable片剂tailingfactor拖尾因子tailingpeak拖尾峰testsolution试液thermalanalysis热分析法thermalconductivitydetector热导检测器thermogravimetricanalysis热重分析法TheUnitedStatesPharmacopoeia美国药典ThePharmacopoeiaofJapan日本药局方thinlayerchromatography薄层色谱thiochromereaction硫色素反应thymol百里酚thymolphthalein百里酚酞titer滴定度three-dimensionalchromatogram三维色谱图titrant滴定剂titrationerror滴定误差titrimetricanalysis滴定分析法tolerance容许限totalash总灰分totalqualitycontrol全面质量控制traditionaldrugs传统药traditionalChinesemedicine中药turbidance浑浊turbidimetricassay浊度测定法turbidimetry比浊度turbidity浊度Uultracentrifugation超速离心ultravioletirradiation紫外线照射unduetoxicity异常毒性uniformdesign均匀设计uniformityofdosageunits含量均匀度uniformityofvolume装量均匀性uniformityofweight重量均匀性Vvalidity可靠性variance方差viscosity粘度volatileoildeterminationapparatus挥发油测定器volatilization挥发性volumetricanalysis容量分析volumetricsolution滴定液volumetricflasks比重瓶Wwavelength波长wavenumber波数weighingbottle称量瓶weighingform称量形式well-closedcontainer密闭容器whiteboard白瓷板XxylenecyanolblueFF二甲苯蓝FFxylenolorange二甲酚橙ZZigzagscanning锯齿扫描zwitterions两性离子Zymolysis酶解作用zoneelectrophoresis区带电泳。

造纸词汇——精选推荐

造纸词汇——精选推荐

制浆工艺impregnator预浸器refiner盘磨机preheater预加热器pre-steaming bin预蒸仓heat recovery热回收thickner浓缩机Twin-Roll Press双辊挤浆机Thickening浓缩HC-bleaching高浓漂白Reject chest渣浆池Reject refiner渣浆池Screw drainer螺旋卸料器Plug screw feeder料塞螺旋喂料器Primary screen一段筛Stator plate定盘Standpipe立管Flat zone平盘区Blow line喷放管线Pressure cyclone压力旋风分离器Gravity重力Impurity杂质Extractive抽取物Manganese锰Equalizing bin匀料仓Rotomixer转子混合器Bleaching liquor漂液Disc screen盘筛Level indicator液位指示器Metering screw计量螺旋Gyratory screen旋筛Reclaim卸料Screw feeder螺旋喂料器Distallition蒸馏Shive纤维束Barometric leg水腿Filtrate滤液White water chest白水池Dewater脱水Pressurized preheating常压预加热Single-disc refiner单盘盘磨机Latency潜能Preheater加热器Double-disc refiner双盘盘磨机Load split荷载分配Coarse fiber粗纤维Reject浆渣Single-stage refining一段磨浆Pilot scale中试厂Energy consumption能耗Tear strength撕裂强度Retention time滞留时间Overpressure超压Lamella薄片Fiber wall纤维墙Compressed steam压缩蒸汽Soft fiber软纤维Moisture content水份Softness柔软度Toughness硬度Tensile index抗张指数Tear index撕裂指数Light scattering光散射系数Bulk松厚度Yield得率Standard newsprint 标准新闻纸Improved newsprint改良新闻纸Saturated steam饱和蒸汽Suspended solid悬浮物Effluent treatment污水处理Dew point露点Screen basket筛鼓Fastening bolt 坚固螺栓Stuffing box填料箱Inspection hatch检查孔Hub轮毂spherical thrust roller bearing球墨止推滚柱轴承fastening screw紧固螺丝friction force摩擦力valve tray 填料方式bubble cap汽泡盖sieve tray滤网盘downcomer下导管weir堰板volatile component挥发元素Gap clearance盘隙Refining intensity磨浆强度Centrifugal force离心力Drag force拖拉力Residence time停留时间Long fiber content长纤维含量Conical refiner椎形盘磨机Breaker bar破碎棒Hydrogen peroxide过氧化氢Sodium hydroxide氢氧化钠Sodium silicate硅酸钠Sodium sulfite亚硫酸钠Hydrosulfite次硫酸钠transducer传感器thermometer温度计neutral point中性点dynamic balance动态平衡Short circuit current短回路电流The related vocabulary for A package (A包相关词汇)Approach flow system流送系统disc filter多盘Thick stock screening浓浆筛选super clear filtrate超清滤液Fiber recovery纤维回收clear filtrate清滤液Cleaner除砂器cloudy filtrate浊滤液Flying wing Deculator cord packing盘根with cleaner 飞翼式除气器 double suction pump双吸泵Headbox 流浆箱make-up water补充水Wire pit 机外白水槽accept良浆Condenser冷凝器reject尾渣V acuum pump真空泵interface衔接Centrifugal pump离心泵sight glass视镜Diagram pump隔膜泵votex nozzle涡流喷嘴Screw pump螺杆泵throttling valve节流阀Displacement pump置换泵recovered fiber回收纤维WW channel白水方管NBKP漂白针叶硫酸盐浆Dilution headbox screen稀释水筛BCTMP漂白化学热磨机械浆HB screen纸机筛poplar pulp杨木浆Broke thickener chest损纸浓缩浆池sweetener垫层浆Dry broke intermitted chest干损纸中间浆池DIP脱墨浆Silencer消音器broken损纸Seal pit水封池dilution water稀释水Manifolds上浆总管sealing water密封水Separator分离器defibrination纤维疏解V ibrations sensor振动传感器oscillating shower摆动喷淋FC motor变频电机flow sheet流程图Dosing chest配浆池emergency stop急停Mixing chest混合浆池manufacturing drawing制造图Machine chest抄前池foundation drawing基础图Stuffing box填料箱reference drawing参考图Header总管functional diagram功能图Distribution pipe布浆管interlocking diagram连锁图Deflector 导流板over flow溢流Suction side引程侧solid content固含量Head扬程buffer缓冲器Counter flange配对法兰furnish配比Anchor bolt地脚螺栓magnetic flow-meter电磁流量计Slid rail 滑轨periodical variation周期波动Tensioning equipment张紧装置random variation随机波动Wall ring大法兰(墙环)fiber orientation纤维定向Motor stand电机座scaling结垢Fastening element紧固件pressure pulsation压力脉冲Steam heater蒸汽加热器flow evenness均衡流量Plug flow滞流short circulation短循环Transition flow过渡流(混流) air pocket气袋slime腐浆turbulence flow紊流(湍流)Medium-consistency storage tower中浓储浆塔plunger pump潜水泵部分造纸术语:grade 纸种grammage 定量width on reel 卷取纸幅宽coating weight 涂布量moisture before coating 涂前水份moisture on reel 卷取水份steam pressure 蒸汽压力steam consumption 蒸汽灌消耗量wire speed 网速press speed 压榨速度reel speed 卷取速度furnish 浆料配比Temp.in HB 流浆箱浆料温度press data 压榨数据supplier 供应商installed date安装日期days running运行天数style型号basis weight克重tension张力felt width on stretcher张紧辊上毛毯宽度stretched/stretch to go张紧辊张紧位置uhle box 毛毯真空箱vaccum真空度air velocity空气流速vacuum system 真空系统edge shower边缘喷淋水lubrication shower低压润滑喷淋水HP shower高压喷淋水moisture profiles水份图像moisture point measurements水份测量点absorption capability透水度常用高得率浆中英文对照SGW (Stone Ground Wood) 磨石磨木浆PGW (Pressurized Ground Wood) 压力磨石磨木浆TGW (high Temperature Ground Wood) 高温磨石磨木浆RMP (Refiner Mechanical Pulp) 盘磨机械浆TMP (Thermo-Mechanical Pulp) 预热盘磨机械浆CMP (Chemi-Mechanical Pulp) 化学盘磨机械浆CTMP (Chemi-Thermo-Mechanical Pulp) 化学预热机械浆APMP (Alkaline Peroxide Mechanical Pulp) 碱性过氧化氢化学机械浆SCMP (Sulfonated Chemi-Mechanical Pulp) 磺化化学机械浆BMP (Bio-Mechanical Pulp) 生物机械浆SEP (Steam Explosion Pulping) 蒸汽爆破法制浆EMP (Extruder Mechanical Pulp) 挤压法机械浆SCP (Semi-Chemical Pulp) 半化学法浆NSSC (Neutral Sulphite Semi-Chemical pulp) 中性亚硫酸盐法半化学浆ASSC (Alkaline Sulphite Semi-Chemical pulp) 碱性亚硫酸盐法半化学浆各种缩写:AA = atomic absorption原子吸收ABS = acrylonitrile-buladrene styrene丙烯腈—丁;烯—苯乙烯ACAR = angular correlation of annihilation radiation消除辐射的角相关性AM = acrylamide丙烯酰胺AOX = adsorbable organic halides可吸附的有机卤化物AP = plkali pulp碱法纸浆APAM = anionic polyacrylamide阴离子型聚丙烯酰胺ASB = aerotion stabilization basin稳定曝气池AST = activated sludge treatment活性污泥处理BBCT = best convential pollutant cotrol technology最常用污染物控制技术BDMT = bone dry metric tons绝干公吨BME = bipolar membrane electro dialysis两极膜电透析BMP = best management practices最优管理实践BOD = biochemical oxygen demand生化耗氧量BP = boiling point沸点BPK = bleached papergrade kraft and soda(生产)白纸用硫酸盐和荷性纳法浆BPT = best practicable control technology最佳实用控制技术BTU = british thermal unit英热单位BW = basis weight定量CCAD = computer aided design计算机辅助设计CBLI = chemistry-based leak indicator化学(法)示漏器CC = consistency controller浓度调节器CFD = computational fluid dynamics计算流体动力学CI = colour index比色指数= cofidence interval置信区间CL = colored ledger彩色底板CLSM = confocal laser scanning microscopy共焦激光扫描显微镜CMC = carboxy methylated cellulose羧甲基纤维素COMS = compliance optimization modeling system寻优模型系统CP = chemical pulp化学浆= chemical pure化学纯CPPC = coordinated phosphate/pH chemistry controller配位磷酸盐/pH 调节器CR = consistency regulator浓度调节器CRP = chloride removal process氯化物排出法CSD = condensate steam distillation column冷凝汽馏塔CTMP = chemical treatment in terms of sulphonation硫化期间的化学处理= chemithermomechanical pulp化学热磨机械浆CTU = centigrade thermal unit公制热量单位CV = coefficient variation偏离系数= crystal violet结晶紫DD = dioxide二氧化物DAF = dissolved air floatation(溶)气浮DCS = dissolved and colloidal substances溶解与胶态物= distributed control system集散控制系统DELS = Doppler electrophoretic light scattering多普勒电泳光扫描DIP = deinked pulp脱墨纸浆DKP = deinked kraft pulp脱墨牛皮纸浆DLK = double-line clippings双线限位DMS = dynamic mechanical spectroscopy动力谱学DMSO = dimethyl sulfoxide二甲亚砜DMT = dimethyl terephthalate对邻苯二甲酸二甲酯DO = dissolved oxygen溶解氧DP = degree of polymerization聚合度DSC = differential scanning calorimetry微分扫描量热法DVC = digital valve controller数字伐控制器EEC = embedded costs插入成本ECF = elemental chlorine free无元素氯(漂白)EDTA = ethylene eiamine tetraacetic acid乙二胺四乙酸EPC = experimental prismatic calcite实验棱镜方解石ERV = estimated replacement value预计取代值ESP = electrostatic precipitator静电滤尘器= emergency shutdown procedure事故停机程序EVA = ethylene vinyl acetate乙烯乙酸乙烯酯ESPRA = empire state paper research associates国立造纸研究会EVOH = ethylene-vinyl alcohol乙烯-乙烯醇FFAS = formamidine sulfinic acid甲脒亚磺酸FBB = folding box board折叠箱纸板FBK = fully bleached kraft全漂牛皮纸FC = flow controller流量控制器FID = free induction decays自由感应衰减FP = freezing point冰点;凝固点GGDP = gross domestic product本国生产总值GEMS = general energy and materials balance system通用能量和物料平衡系统GLC = gas-liquid chromatography气液色谱GPC = gel permeation chromatographic analysis凝胶渗透色谱分析GPM = gallons per minute加仑/分钟HHC = high consistency高浓HCR = high consistency refiner高浓磨浆机HD = high density高密度HPR = high production rate高生产率HPSEC = high-performance size-exclusion chromatography高性能粒度筛析色谱法HRT = hydraulic retention time水力停留时间HTH = high test hypochlorite高级漂粉HV = high voltage高压HW = hardwood硬木IIMPM = interactive multiplanar model相互作用的多面模型IPST = institute of paper science and technology造纸科技研究院IWC = international water consultants国际水质顾问团JJIT = just-in-time正好;准时KKP = kraft pulp牛皮浆;硫酸盐浆LLC = level controller液面控制器LCC = lignin-carbohydrate complexes木素-碳水化合物复合体LCL = lower control limits控制下限LCR = level cotroller and recorder液面控制记录仪LDPE = low density poly ethylene低密度聚乙烯LDV = laser Doppler velocimetry激光多普勒测速法LIVG = low inlet velocity gasification process低入口速度气化工艺LPR = low production rate低生产率LRD = long rang dependence广范围相关LVDT = linear position transducer线性位移变送器LWC = lightweight coated低定量涂布的MMACT = maximum achievable control technology最大可达控制技术MAP = modified atmosphere packaging改良常压包装法MC = marginal cost边际成本= medium consistency中浓(度)MDI = methylendiphenyl diisocyanate亚甲苯二苯二异氰酸酯MeB = methylene blue亚甲基兰,四甲基兰MEK = methyl ethyl ketone甲(基)乙(基)酮MF = machine finished机械整饰的MG = machine glazed机械上光的= malachte green孔雀绿MISS = mixed liquor suspended solids (有机物与活性污泥 )混合液中悬浮固体MOW = mixed office waste混合办公废纸MRP = matal removal process金属(离子)脱除过程MSW = municipal solid waste城市固体废物MVP = moisture vapor permeability水蒸汽渗透性MWL = milled wood lignin磨木木素NNC = nitrocellulose 硝化纤维素NF = nanofiltration超滤 (毫微过滤)NMR = nuclear magnetic resonance核磁共振NSPS = new source performance standards新的资源性能标准NSSC = neutral sulfite semi-chemical pulp中性亚硫酸半化学浆OOCC = old corrugated container旧瓦楞纸箱OD = over dry绝干;烘干OEE = overall equipment efficiency总设备效率OIT = oxidative induction temperature氧化起始温度O&M = operating and maintenance 使用与维护ONP = old newspaper旧新闻纸OPP = oriented polypropylene取向聚丙烯OPR = oil penetration rates渗油率OWL = oxidized white liquor氧化白液PPAL = positron annihilation life time正电子湮没寿命PC = pressure controller压力调节器PCA = principal components analysis主成分分析PCC = precipitated calcium carbonate沉淀碳酸钙PCR = pressure controller and recorder压力调节记录仪PDSC = pressure differential scanning colorimetry压差扫描量热术PEMS = predictive emissions modeling system预测排放模型系统PEO = poly ethylene oxide聚氧化乙烯PGS = papergrade sulfite造纸用硫磺PGW = pressurized groundwood压力磨木浆PM = paper machine 造纸机;抄纸机PM/ECCM = preventive maintenance and essential care and condition monitoring预防维修/基本维修及状态监测PP = polypropylene聚丙烯PSES = pretreatment standards for existing sources现存资源预测标准PSM = process safety management(生产)过程安全管理PTFE = polytetrafluoroethylene聚四氟乙烯PTR = photothermal radiometry光热辐射分析法PVC = polyvinylchloride聚氯乙烯PVDC = polyvinyl dichloride聚二氯乙烯PVSK = polyvinylsulfate聚乙烯硫酸酯RRDH = rapid displacement heating快速置换加热法RH = relative humidity相对湿度RMP = refiner mechanical pulp木片磨木浆;盘磨机械浆RN = regular number纸板标准号RT = radiographic testing射线照相试验,X射线检验SSBK = solid bleached kraft(同质)漂白牛皮纸SBR = sequencing batch reactors程序化间歇反应器SC = super calendered超级压光的SDI = silt density index淤泥浓度指数SE = supplemental energy补充能量;辅助能SEC = size exclusion chromatographic粒度筛析色谱法SEM = scanning electron microscope扫描电子显微镜SEM-EDS = scanning electron microscope-energy dispersive spectrometry扫描电子显微镜—能量分散能谱测定法SGW = stone ground wood磨石磨木浆SIF = stress intensity factor应力强度系数;应力强化因子SOPs = standard operating procedures标准作业程序SP = sulphite pulp亚硫酸盐纸浆SPC = satislical process control过程控制SRT = solids retention time粒子留着时间SUB = solid unbleached board(同质)本色浆纸板SW = softwood软木;针叶树SWL = sulphite waste liguor亚硫酸盐废液TTAC = totally applied chlorine总用氯量TC = temperature controller温度调节器TCDF = tetrachlorodibenzofuran四氯二苯并呋喃TCF = totally chlorine-free全无氯(漂白)TCR = temperature controller and recorder温度调节记录仪TGA = thermal gravimetric analysis热重分析TLA = thin layer activation薄层活性化TMP = thermo mechanical pulp热磨机械浆TP = thermo-plastic热塑性的TQ = threshold quantity临界量(值)TRS = total reduced sulfur总还原硫TS = tensile strength抗张强度TSS = total suspended solids总悬浮固体量UUBB = unbeached board本色(浆)纸板UBK = unbeached kraft本色牛皮纸UCL = upper control limits控制上限UT = ultrasonic testing超声试验UV = ultraviolet紫外光VVOC = volatile organic compound挥发性有机化合物WWAS = waste-activated sludge废活性污泥WFMT = wet fluorescent magnetic particle test湿荧光磁粉试验WL = white ledger白色帐簿纸WLC = white-lined chipboard白浆衬里的粗纸板WP = wood pulp木浆WVTR = water vapor transmission rate水蒸汽传递速度YYI = yellow index返黄值;返黄指数YP = yield point屈服(软化)点。

不同程度控制性降压对脊柱侧弯矫形术失血量、肾脏功能和脊髓诱发电位变化的影响

不同程度控制性降压对脊柱侧弯矫形术失血量、肾脏功能和脊髓诱发电位变化的影响

•临床研究•不同程度控制性降压对脊柱侧弯矫形术失血量、肾脏功能和脊髓诱发电位变化的影响李益智#,宋歌2,张昊鹏&,董海龙&(#解放军第一医院临夏医疗所麻醉科,甘肃临夏731100; 2江苏省连云港市第一人民医院麻醉科,江苏连云港222000; &第四军医大学附属西京医院麻醉与围术期医学科,陕西西安710032)[摘要]目的比较不同程度控制性降压对脊柱侧弯矫形术术中失血量、肾脏功能和脊髓诱发电位变化的影响。

方法选取第四军医大学附属西京医院40例ASA I或"级行原发性脊柱侧弯矫形术的患者。

全部采用全凭静脉麻醉,术中给予硝普钠微量菜输注行控制性降压。

根据控制性降压期间维持平均动脉压的不同水平随机分为2组:A组平均动脉压(MAP)维持在(60 ±5)mrnHg,B组维持在(70±5)mmHg。

比较2组间失血量、输血量、尿量的多少及术中脊髓诱发电位变化幅度的差异。

结果A组术中失血量及输血量与B组相比明显减少,其差异具有统计学意义(!<0.05),2组间尿量及脊髓诱发电位变化幅度的差异无统计学意义。

结论脊柱侧弯矫形术中行控制性降压时维持MAP在60 mmHg左右时,术中失血量明显减少,且对肾脏和脊髓功能没有明显影响,可为临床应用提供参考。

[关键词]脊柱侧弯矫形术;控制性降压;血液保护D O I:10. 3969/j.iss n. 2096 -2681.2018.02.003The influence of controlled hypotensionamplitude onbloodloss, renal functionand spinal cord evoked potential changes in primary scoliosis surgeryLI Yizlii1,SONG Ge2,ZHANG Haopeng3,DONG Hailong31D epartm ent of Anesthesiology,Linxia M edical Point,the First H ospital of the PLA,Linxia731100; 2D epartm ent of Anesthesiology,theFirst People’s H ospital of Lianyungang,Lianyungang222000; 3D epartm ent of Anesthesiology and Preoperative Medicine,Xijing Hospital,Fourtli M ilitary M edical University,Xfan710032,ChinaCorresponding author:DONG Hailong,E-mail:donghl@fm m [A bstract] Objective To com pare the influence of controlled hypotension am plitude on blood loss,renal function and spinal cordevoked potential changes in prim ary scoliosis surgery.Methods Forty ASA I -"patients scheduled for elective prim ary scoliosis sur­gery under total intravenous anesthiesia were random ly divided into tw o groups depending on the am plitude of controlled hypotension:group A,the m ean arterial p ressure( MAP) w ere controlled at(60 ±5) mmHg;group B,The m ean arterial pressure( MAP) were con­trolled at(70 ±5) m m H g.Blood loss,transfusion volume,urine volum e and spinal cord evoked potential changes were between the tw o groups.Results Com pared w ith group B,blood loss and blood transfusion were significantly reduc 0.05).However,n o significant changes were found in urine volum e and spinal cord evoked potential chang Conclusion I n prim ary scoliosis surgery,m aintaining M AP around(60 ±5) m m H g w ith controlled hypotension can significantly reduceblood loss,but have no significant effect on the kidneys and spinal cord function.[Key words]prim ary scoliosis surgery;controlled hypotension;blood conservation脊柱侧弯矫形手术创伤大,时间长,加之骨膜 采用控制性降压的方法来减少术中失血量,减少输渗血不易止血,失血量相对比较多。

柴油总污染物与机械杂质、堵塞倾向性的相关性

柴油总污染物与机械杂质、堵塞倾向性的相关性

柴油总污染物与机械杂质、堵塞倾向性的相关性发表时间:2019-04-11T16:19:44.937Z 来源:《电力设备》2018年第30期作者:杨丽娟梁宝华[导读] 摘要:国六柴油新增检测项目总污染物测定与机械杂质测定、柴油堵塞倾向性的测定,三者都是反映柴油清洁性能的重要质量指标。

(中国石油西北销售公司质量计量管理部兰州监督检验站甘肃 730060)摘要:国六柴油新增检测项目总污染物测定与机械杂质测定、柴油堵塞倾向性的测定,三者都是反映柴油清洁性能的重要质量指标。

通过试验方法比较和实际试验比对,发现柴油总污染物与机械杂质和堵塞倾向性(柴油堵塞倾向性实验操作作业指导书方法,下同)之间有一定的相关性。

Correlation between Total Diesel Contaminants and Mechanical Impusions and Blocking TendencyABSTRACTthe determination of total pollutants and mechanical impurity, and the tendency of diesel blockage are all important quality indexes to reflect the clean performance of diesel oil. By comparing the test method with the actual test, it is found that there is a certain correlation between the total diesel pollutant and the mechanical impurity and blockage tendency(the experimental operation instruction method for diesel congestion tendency, the same below).关键词:柴油、总污染物、机械杂质、堵塞倾向性、相关性1.前言从2018年起开始我国大部分地区已执行车用柴油(Ⅵ)标准。

药物分析专业英语词汇

药物分析专业英语词汇

药物分析专业英语词汇AAbbe refractometer 阿贝折射仪absorbance 吸收度absorbance ratio 吸收度比值absorption 吸收absorption curve 吸收曲线absorption spectrum 吸收光谱absorptivity 吸收系数accuracy 准确度acid-dye colorimetry 酸性染料比色法acidimetry 酸量法acid-insoluble ash 酸不溶性灰分acidity 酸度activity 活度additive 添加剂additivity 加和性adjusted retention time 调整保存时间adsorbent 吸附剂adsorption 吸附affinity chromatography 亲和色谱法aliquot 〔一〕份alkalinity 碱度alumina 氧化铝ambient temperature 室温ammonium thiocyanate 硫氰酸铵analytical quality control〔AQC〕分析质量控制anhydrous substance 枯燥品anionic surfactant titration 阴离子外表活性剂滴定法antibiotics-microbial test 抗生素微生物检定法antio*idant 抗氧剂appendi* 附录application of sample 点样area normalization method 面积归一化法argentimetry 银量法arsenic 砷arsenic stain 砷斑ascending development 上行展开ash-free filter paper 无灰滤纸〔定量滤纸〕assay 含量测定assay tolerance 含量限度atmospheric pressureionization(API) 大气压离子化attenuation 衰减Bback e*traction 反萃取back titration 回滴法bacterial endoto*ins test 细菌毒素检查法band absorption 谱带吸收baseline correction 基线校正baseline drift 基线漂移batch, lot 批batch(lot) number 批号Benttendorff method 白田道夫〔检砷〕法between day (day to day, inter-day) precision 日间精细度between run (inter-run) precision 批间精细度biotransformation 生物转化bioavailability test 生物利用度试验bioequivalence test 生物等效试验biopharmaceutical analysis 体药物分析,生物药物分析blank test 空白试验boiling range 沸程British Pharmacopeia (BP) 英国药典bromate titration 溴酸盐滴定法bromimetry 溴量法bromocresol green 溴甲酚绿bromocresol purple 溴甲酚紫bromophenol blue 溴酚蓝bromothymol blue 溴麝香草酚蓝bulk drug, pharmaceutical product 原料药buret 滴定管by-product 副产物Ccalibration curve 校正曲线calomel electrode 甘汞电极calorimetry 量热分析capacity factor 容量因子capillary zone electrophoresis (CZE) 毛细管区带电泳capillary gas chromatography 毛细管气相色谱法carrier gas 载气cation-e*change resin 阳离子交换树脂ceri(o)metry 铈量法characteristics, description 性状check valve 单向阀chemical shift 化学位移chelate pound 鳌合物chemically bonded phase 化学键合相chemical equivalent 化学当量Chinese Pharmacopeia (ChP) 中国药典Chinese material medicine 中成药Chinese materia medica 中药学Chinese materia medica preparation 中药制剂Chinese Pharmaceutical Association (CPA) 中国药学会chiral 手性的chiral stationary phase (CSP) 手性固定相chiral separation 手性别离chirality 手性chiral carbon atom 手性碳原子chromatogram 色谱图chromatography 色谱法chromatographic column 色谱柱chromatographic condition 色谱条件chromatographic data processor 色谱数据处理机chromatographic work station 色谱工作站clarity 澄清度clathrate, inclusion pound 包合物clearance 去除率clinical pharmacy 临床药学coefficient of distribution 分配系数coefficient of variation 变异系数color change interval 〔指示剂〕变色围color reaction 显色反响colorimetric analysis 比色分析colorimetry 比色法column capacity 柱容量column dead volume 柱死体积column efficiency 柱效column interstitial volume 柱隙体积column outlet pressure 柱出口压column temperature 柱温column pressure 柱压column volume 柱体积column overload 柱超载column switching 柱切换mittee of drug evaluation 药品审评委员会parative test 比拟试验pleteness of solution 溶液的澄清度pound medicines 复方药puter-aided pharmaceutical analysis 计算机辅助药物分析concentration-time curve 浓度-时间曲线confidence interval 置信区间confidence level 置信水平confidence limit 置信限congealing point 凝点congo red 刚果红〔指示剂〕content uniformity 装量差异controlled trial 对照试验correlation coefficient 相关系数contrast test 对照试验counter ion 反离子〔平衡离子〕cresol red 甲酚红〔指示剂〕crucible 坩埚crude drug 生药crystal violet 结晶紫〔指示剂〕cuvette, cell 比色池cyanide 氰化物cyclode*trin 环糊精cylinder, graduate cylinder, measuring cylinder 量筒cylinder-plate assay 管碟测定法Ddaughter ion 〔质谱〕子离子dead space 死体积dead-stop titration 永停滴定法dead time 死时间decolorization 脱色deposition point 分解点deflection 偏差deflection point 拐点degassing 脱气deionized water 去离子水deliquescence 潮解depressor substances test 降压物质检查法derivative spectrophotometry 导数分光光度法derivatization 衍生化descending development 下行展开desiccant 枯燥剂detection 检查detector 检测器developer, developing reagent 展开剂developing chamber 展开室deviation 偏差de*trose 右旋糖,葡萄糖diastereoisomer 非对映异构体diazotization 重氮化2,6-dichlorindophenol titration 2,6-二氯靛酚滴定法differential scanning calorimetry (DSC) 差示扫描热量法differential spectrophotometry 差示分光光度法differential thermal analysis (DTA) 差示热分析differentiating solvent 区分性溶剂diffusion 扩散digestion 消化diphastic titration 双相滴定disintegration test 崩解试验dispersion 分散度dissolubility 溶解度dissolution test 溶出度检查distilling range 馏程distribution chromatography 分配色谱distribution coefficient 分配系数dose 剂量drug control institutions 药检机构drug quality control 药品质量控制drug release 药物释放度drug standard 药品标准drying to constant weight 枯燥至恒重dual wavelength spectrophotometry 双波长分光光度法duplicate test 重复试验Eeffective constituent 有效成分effective plate number 有效板数efficiency of column 柱效electron capture detector 电子捕获检测器electron impact ionization 电子轰击离子化electrophoresis 电泳electrospray interface 电喷雾接口electromigration injection 电迁移进样elimination 消除eluate 洗脱液elution 洗脱emission spectrochemical analysis 发射光谱分析enantiomer 对映体end absorption 末端吸收end point correction 终点校正endogenous substances 源性物质enzyme immunoassay(EIA) 酶免疫分析enzyme drug 酶类药物enzyme induction 酶诱导enzyme inhibition 酶抑制eosin sodium 曙红钠〔指示剂〕epimer 差向异构体equilibrium constant 平衡常数equivalence point 等当点error in volumetric analysis 容量分析误差e*citation spectrum 激发光谱e*clusion chromatography 排阻色谱法e*piration date 失效期e*ternal standard method 外标法e*tract 提取物e*traction gravimetry 提取重量法e*traction titration 提取容量法e*trapolated method 外插法,外推法Ffactor 系数,因数,因子feature 特征Fehling‘s reaction 费林反响field disorption ionization 场解吸离子化field ionization 场致离子化filter 过滤,滤光片filtration 过滤fineness of the particles 颗粒细度flame ionization detector(FID) 火焰离子化检测器flame emission spectrum 火焰发射光谱flask 烧瓶flow cell 流通池flow injection analysis 流动注射分析flow rate 流速fluorescamine 荧胺fluorescence immunoassay(FIA) 荧光免疫分析fluorescence polarization immunoassay(FPIA) 荧光偏振免疫分析fluorescent agent 荧光剂fluorescence spectrophotometry 荧光分光光度法fluorescence detection 荧光检测器fluorimetyr 荧光分析法foreign odor 异臭foreign pigment 有色杂质formulary 处方集fraction 馏分freezing test 结冻试验funnel 漏斗fused peaks, overlapped peaks 重叠峰fused silica 熔融石英Ggas chromatography(GC) 气相色谱法gas-liquid chromatography(GLC) 气液色谱法gas purifier 气体净化器gel filtration chromatography 凝胶过滤色谱法gel permeation chromatography 凝胶渗透色谱法general identification test 一般鉴别试验general notices 〔药典〕凡例general requirements 〔药典〕通则good clinical practices(GCP) 药品临床管理规good laboratory practices(GLP) 药品实验室管理规good manufacturing practices(GMP) 药品生产质量管理规good supply practices(GSP) 药品供给管理规gradient elution 梯度洗脱grating 光栅gravimetric method 重量法Gutzeit test 古蔡〔检砷〕法Hhalf peak width 半峰宽[halide] disk method, wafer method, pellet method 压片法head-space concentrating injector 顶空浓缩进样器heavy metal 重金属heat conductivity 热导率height equivalent to a theoretical plate 理论塔板高度height of an effective plate 有效塔板高度high-performance liquid chromatography (HPLC) 高效液相色谱法high-performance thin-layer chromatography (HPTLC) 高效薄层色谱法hydrate 水合物hydrolysis 水解hydrophilicity 亲水性hydrophobicity 疏水性hydroscopic 吸湿的hydro*yl value 羟值hyperchromic effect 浓色效应hypochromic effect 淡色效应Iidentification 鉴别ignition to constant weight 灼烧至恒重immobile phase 固定相immunoassay 免疫测定impurity 杂质inactivation 失活inde* 索引indicator 指示剂indicator electrode 指示电极inhibitor 抑制剂injecting septum 进样隔膜胶垫injection valve 进样阀instrumental analysis 仪器分析insulin assay 胰岛素生物检定法integrator 积分仪intercept 截距interface 接口interference filter 干预滤光片intermediate 中间体internal standard substance 标物质international unit(IU) 国际单位in vitro 体外in vivo 体iodide 碘化物iodoform reaction 碘仿反响iodometry 碘量法ion-e*change cellulose 离子交换纤维素ion pair chromatography 离子对色谱ion suppression 离子抑制ionic strength 离子强度ion-pairing agent 离子对试剂ionization 电离,离子化ionization region 离子化区irreversible indicator 不可逆指示剂irreversible potential 不可逆电位isoabsorptive point 等吸收点isocratic elution 等溶剂组成洗脱isoelectric point 等电点isoosmotic solution 等渗溶液isotherm 等温线KKarl Fischer titration 卡尔·费歇尔滴定kinematic viscosity 运动黏度Kjeldahl method for nitrogen 凯氏定氮法Kober reagent 科伯试剂Kovats retention inde* 科瓦茨保存指数Llabelled amount 标示量leading peak 前延峰least square method 最小二乘法leveling effect 均化效应licensed pharmacist 执业药师limit control 限量控制limit of detection(LOD) 检测限limit of quantitation(LOQ) 定量限limit test 〔杂质〕限度〔或限量〕试验limutus amebocyte lysate(LAL) 鲎试验linearity and range 线性及围linearity scanning 线性扫描liquid chromatograph/mass spectrometer (LC/MS) 液质联用仪litmus paper 石蕊试纸loss on drying 枯燥失重low pressure gradient pump 低压梯度泵luminescence 发光lyophilization 冷冻枯燥Mmain constituent 主成分make-up gas 尾吹气maltol reaction 麦牙酚试验Marquis test 马奎斯试验mass analyzer detector 质量分析检测器mass spectrometric analysis 质谱分析mass spectrum 质谱图mean deviation 平均偏差measuring flask, volumetric flask 量瓶measuring pipet(te) 刻度吸量管medicinal herb 草药melting point 熔点melting range 熔距metabolite 代物metastable ion 亚稳离子methyl orange 甲基橙methyl red 甲基红micellar chromatography 胶束色谱法micellar electrokinetic capillary chromatography(MECC, MEKC) 胶束电动毛细管色谱法micelle 胶束microanalysis 微量分析microcrystal 微晶microdialysis 微透析micropacked column 微型填充柱microsome 微粒体microsyringe 微量注射器migration time 迁移时间millipore filtration 微孔过滤minimum fill 最低装量mobile phase 流动相modifier 改性剂,调节剂molecular formula 分子式monitor 检测,监测monochromator 单色器monographs 正文mortar 研钵moving belt interface 传送带接口multidimensional detection 多维检测multiple linear regression 多元线性回归multivariate calibration 多元校正Nnatural product 天然产物Nessler glasses(tube) 奈斯勒比色管Nessler‘s reagent 碱性碘化汞钾试液neutralization 中和nitrogen content 总氮量nonaqueous acid-base titration 非水酸碱滴定nonprescription drug, over the counter drugs (OTC drugs) 非处方药nonproprietary name, generic name 非专有名nonspecific impurity 一般杂质non-volatile matter 不挥发物normal phase 正相normalization 归一化法notice 凡例nujol mull method 石蜡糊法Ooctadecylsilane chemically bonded silica 十八烷基硅烷键合硅胶octylsilane 辛〔烷〕基硅烷odorless 无臭official name 法定名official specifications 法定标准official test 法定试验on-column detector 柱上检测器on-column injection 柱头进样on-line degasser 在线脱气设备on the dried basis 按枯燥品计opalescence 乳浊open tubular column 开管色谱柱optical activity 光学活性optical isomerism 旋光异构optical purity 光学纯度optimization function 优化函数organic volatile impurities 有机挥发性杂质orthogonal function spectrophotometry 正交函数分光光度法orthogonal test 正交试验orthophenanthroline 邻二氮菲outlier 可疑数据,逸出值overtones 倍频峰,泛频峰o*idation-reduction titration 氧化复原滴定o*ygen flask bustion 氧瓶燃烧Ppacked column 填充柱packing material 色谱柱填料palladium ion colorimetry 钯离子比色法parallel analysis 平行分析parent ion 母离子particulate matter 不溶性微粒partition coefficient 分配系数parts per million (ppm) 百万分之几pattern recognition 模式识别peak symmetry 峰不对称性peak valley 峰谷peak width at half height 半峰宽percent transmittance 透光百分率pH indicator absorbance ratio method pH指示剂吸光度比值法pharmaceutical analysis 药物分析pharmacopeia 药典pharmacy 药学phenolphthalein 酚酞photodiode array detector(DAD) 光电二极管阵列检测器photometer 光度计pipeclay triangle 泥三角pipet(te) 吸移管,精细量取planar chromatography 平板色谱法plate storage rack 薄层板贮箱polarimeter 旋光计polarimetry 旋光测定法polarity 极性polyacrylamide gel 聚丙酰胺凝胶polyde*tran gel 葡聚糖凝胶polystyrene gel 聚苯乙烯凝胶polystyrene film 聚苯乙烯薄膜porous polymer beads 高分子多孔小球post-column derivatization 柱后衍生化potentiometer 电位计potentiometric titration 电位滴定法precipitation form 沉淀形式precision 精细度pre-column derivatization 柱前衍生化preparation 制剂prescription drug 处方药pretreatment 预处理primary standard 基准物质principal ponent analysis 主成分分析programmed temperature gas chromatography 程序升温气相色谱法prototype drug 原型药物provisions for new drug approval 新药审批方法purification 纯化purity 纯度pyrogen 热原pyometric method 比重瓶法Qquality control(QC) 质量控制quality evaluation 质量评价quality standard 质量标准quantitative determination 定量测定quantitative analysis 定量分析quasi-molecular ion 准分子离子Rracemization 消旋化radioimmunoassay 放射免疫分析法random sampling 随机抽样rational use of drug 合理用药readily carbonizable substance 易炭化物reagent sprayer 试剂喷雾器recovery 回收率reference electrode 参比电极refractive inde* 折光指数related substance 有关物质relative density 相对密度relative intensity 相对强度repeatability 重复性replicate determination 平行测定reproducibility 重现性residual basic hydrolysis method 剩余碱水解法residual liquid junction potential 剩余液接电位residual titration 剩余滴定residue on ignition 炽灼残渣resolution 分辨率,别离度response time 响应时间retention 保存reversed phase chromatography 反相色谱法reverse osmosis 反渗透rider peak 驼峰rinse 清洗,淋洗robustness 可靠性,稳定性routine analysis 常规分析round 修约〔数字〕ruggedness 耐用性Ssafety 平安性Sakaguchi test 坂口试验salt bridge 盐桥salting out 盐析sample applicator 点样器sample application 点样sample on-line pretreatment 试样在线预处理sampling 取样saponification value 皂化值saturated calomel electrode(SCE) 饱和甘汞电极selectivity 选择性separatory funnel 分液漏斗shoulder peak 肩峰signal to noise ratio 信噪比significant difference 显著性差异significant figure 有效数字significant level 显著性水平significant testing 显著性检验silanophilic interaction 亲硅羟基作用silica gel 硅胶silver chloride electrode 氯化银电极similarity 相似性simultaneous equations method 解线性方程组法size e*clusion chromatography(SEC) 空间排阻色谱法sodium dodecylsulfate, SDS 十二烷基硫酸钠sodium he*anesulfonate 己烷磺酸钠sodium taurocholate 牛璜胆酸钠sodium tetraphenylborate 四苯硼钠sodium thiosulphate 硫代硫酸钠solid-phase e*traction 固相萃取solubility 溶解度solvent front 溶剂前沿solvophobic interaction 疏溶剂作用specific absorbance 吸收系数specification 规格specificity 专属性specific rotation 比旋度specific weight 比重spiked 参加标准的split injection 分流进样splitless injection 无分流进样spray reagent 〔平板色谱中的〕显色剂spreader 铺板机stability 稳定性standard color solution 标准比色液standard deviation 标准差standardization 标定standard operating procedure(SOP) 标准操作规程standard substance 标准品stationary phase coating 固定相涂布starch indicator 淀粉指示剂statistical error 统计误差sterility test 无菌试验stirring bar 搅拌棒stock solution 储藏液stoichiometric point 化学计量点storage 贮藏stray light 杂散光substituent 取代基substrate 底物sulfate 硫酸盐sulphated ash 硫酸盐灰分supercritical fluid chromatography(SFC) 超临界流体色谱法support 载体〔担体〕suspension 悬浊液swelling degree 膨胀度symmetry factor 对称因子syringe pump 注射泵systematic error 系统误差system model 系统模型system suitability 系统适用性Ttablet 片剂tailing factor 拖尾因子tailing peak 拖尾峰tailing-suppressing reagent 扫尾剂test of hypothesis 假设检验test solution(TS) 试液tetrazolium colorimetry 四氮唑比色法therapeutic drug monitoring(TDM) 治疗药物监测thermal analysis 热分析法thermal conductivity detector 热导检测器thermocouple detector 热电偶检测器thermogravimetric analysis(TGA) 热重分析法thermospray interface 热喷雾接口The United States Pharmacopoeia(USP) 美国药典The Pharmacopoeia of Japan(JP) 日本药局方thin layer chromatography(TLC) 薄层色谱法thiochrome reaction 硫色素反响three-dimensional chromatogram 三维色谱图thymol 百里酚〔麝香草酚〕〔指示剂〕thymolphthalein 百里酚酞〔麝香草酚酞〕〔指示剂〕thymolsulfonphthalein ( thymol blue) 百里酚蓝〔麝香草酚蓝〕〔指示剂〕titer, titre 滴定度time-resolved fluoroimmunoassay 时间分辨荧光免疫法titrant 滴定剂titration error 滴定误差titrimetric analysis 滴定分析法tolerance 容许限toluene distillation method 甲苯蒸馏法toluidine blue 甲苯胺蓝〔指示剂〕total ash 总灰分total quality control(TQC) 全面质量控制traditional drugs 传统药traditional Chinese medicine 中药transfer pipet 移液管turbidance 混浊turbidimetric assay 浊度测定法turbidimetry 比浊法turbidity 浊度Uultracentrifugation 超速离心ultrasonic mi*er 超生混合器ultraviolet irradiation 紫外线照射undue to*icity 异常毒性uniform design 均匀设计uniformity of dosage units 含量均匀度uniformity of volume 装量均匀性〔装量差异〕uniformity of weight 重量均匀性〔片重差异〕Vvalidity 可靠性variance 方差versus …对…,…与…的关系曲线viscosity 粘度volatile oil determination apparatus 挥发油测定器volatilization 挥发法volumetric analysis 容量分析volumetric solution(VS) 滴定液vorte* mi*er 涡旋混合器Wwatch glass 外表皿wave length 波长wave number 波数weighing bottle 称量瓶weighing form 称量形式weights 砝码well-closed container 密闭容器**ylene cyanol blue FF 二甲苯蓝FF 〔指示剂〕*ylenol orange 二甲酚橙〔指示剂〕Zzigzag scanning 锯齿扫描zone electrophoresis 区带电泳zwitterions 两性离子zymolysis 酶解作用。

半导体制造的常用名词

半导体制造的常用名词

半导体制造的常用名词发表于: 2007-5-07 17:10 作者: luhaoxinglhx 来源: 半导体技术天地Ingot - A cylindrical solid made of polycrystalline or single crystal silicon from which wafers are cut.晶锭- 由多晶或单晶形成的圆柱体,晶圆片由此切割而成。

Laser Light-Scattering Event - A signal pulse that locates surface imperfections on a wafer.激光散射- 由晶圆片表面缺陷引起的脉冲信号。

Lay - The main direction of surface texture on a wafer.层- 晶圆片表面结构的主要方向。

Light Point Defect (LPD) (Not preferred; see localized light-scatterer)光点缺陷(LPD) (不推荐使用,参见“局部光散射”)Lithography - The process used to transfer patterns onto wafers.光刻- 从掩膜到圆片转移的过程。

Localized Light-Scatterer - One feature on the surface of a wafer, such as a pit or a scratch that scatters light. It is also called a light point defect.局部光散射- 晶圆片表面特征,例如小坑或擦伤导致光线散射,也称为光点缺陷。

Lot - Wafers of similar sizes and characteristics placed together in a shipment.批次- 具有相似尺寸和特性的晶圆片一并放置在一个载片器内。

药物分析常用英语词汇

药物分析常用英语词汇

药物分析专业英语词汇表Aabsorbance吸收度absorbanceratio吸收度比值absorption吸收absorptioncurve吸收曲线absorptioncoefficient吸收系数accuratevalue准确值Acid—dyecolormcty酸性染料比色法acidimcty酸量法acidity酸度activity活度adjustedretentiontime调整保留时间absorbent吸收剂absorption吸附alkalinity碱度alumina氧化铝,矾土ambienttemperature室温ammoniumthiocyanate硫氰酸铵analyticalqualitycontrol分析质量控制anhydroussubstance 干燥品antioxidant抗氧剂applicationofsample点样areanormalizationmethod面积归一法arsenic砷arsenicsport砷斑assay含量测定assaytolerance含量限度attenuation衰减acidburette酸式滴定管alkaliburette碱式滴定管amortar研钵Bbackextraction反萃取bandabsorption谱带吸收batch批batchnumber批号Benttendorlfmethod白田道夫法betweendayprecision日间密度精biotransformation生物转化blanktest空白试验boilingrange沸程BritishPharmacopeia英国药典bromatetitration溴酸盐滴定法brominemethod溴量法bromothymolblue溴麝香酚蓝bulkdrug原料药by—product副产物breaker烧杯buretteglassbeadnozzle滴定管brownacidburette棕色酸式滴定管Ccalibrationcurve校正曲线calomelelectrode甘汞电极calorimetry量热分析capacityfactor容量因子capillarygaschromatography毛细管气相色谱法carriergas载气characteristicsdescription性状chelatecompound螯合物chemicalequivalent化学当量Chinesepharmacopeia中国药典Chinesematerialmedicine中成药Chinesematerialmidicalpreparation中药制剂chiral手性的chiralcarbonatom手性碳原子chromatogram色谱图chromatography色谱法chromatographiccolumn色谱柱chromatographiccondition色谱条件clarity澄清度coefficientofdistribution分配系数coefficientofvariation变异系数colorchangeinterval变色范围colorreaction显色反应colormetry比色法columnefficiency柱效columntemperature柱温comparativetest比较试验completenessofsolution溶液的澄清度conjugate缀合物concentration—timecurve浓度时间曲线confidenceinterval置信区间confidencelevel置信水平controlledtrial对照试验correlationcoefficient相关系数contrasttest对照试验congealingpoint凝点contentunifarmity装量差异controlledtrial对照试验correlationcoefficient相关系数contrasttest对照试验counterion反离子cresalred甲酚红cuvettecell比色池cyanide氰化物casserolesmall勺皿Ddead—stoptitration永定滴定法deadtime死时间deflection偏差deflectionpoint拐点degassing脱气deionizedwater去离子水deliquescence潮解depressorsubstancestest降压物质检查法desiccant干燥剂detection检查developingreagent展开剂developingchamber展开室deviation偏差dextrose右旋糖diastereoisomer非对映异构体diazotization重氮化differentialthermalanalysis差示热分析法differentialscanningcalorimetry差示扫描热法Gutzeit古蔡daytodayprecision日间精密度dissolution溶出度directinjection直接进样2,6-dichlorindophenoltitration2,6-二氯靛酚滴定法digestion消化diphastictitration双向滴定disintegrationtest崩解试验dispersion分散度dissolubility溶解度dissolutiontest溶解度检查distillingrange滴程distributionchromatography分配色谱dose剂量drugqualitycontrol药品质量控制dryingtoconstantweight干燥至恒重duplicatetest重复试验diskmethodwatermethod压片法Eeffectiveconstituent有效成分effectiveplatenumber有效板数effectiveofcolumn柱效electrophoresis电泳elimination消除eluate洗脱液elution洗脱enamtiomer对映体endabsorption末端吸收endogenoussubstances内源性物质enzymedrug酶类药物enzymeinduction酶诱导enzymeinhibition酶抑制epimer差向异构体equilibriumconstant平衡常数errorinvolumetricanalysis容量分析误差exclusionchromatography排阻色谱法expirationdate失效期externalstandardmethod外标法extract提取物extrationgravimetry提取重量法extractiontitration提取容量法extrapolatedmethod外插法Erlenmeyerflask锥形瓶evaporatingdishsmall蒸发皿elongatedbulb胖肚electronicbalanceMettlerAL204MettlerAL204电子天平Ffactor系数fehling’sreaction斐林实验filter过滤finenessoftheparticles颗粒细度flowrate流速fluorescentagent荧光剂fluorescencespectrophotometry荧光分光光度法fluorescencedetection荧光检测器fluorescenceanalysis荧光分析法foreignpigment有色杂质formulary处方集free游离freezingtest冻结试验fusedsilica熔融石英filterpaper滤纸Ggaschromatography气相色谱法gas-liquidchromatography气液色谱法gaspurifier气体净化器Generalidentificationtest一般鉴别试验generalnotices凡例Generalrequirements(药典)通则goodclinicalpractices药品临床管理规范goodlaboratorypractices药品实验室管理规范goodmanufacturingpractices(GMP)药品生产质量管理规范goodsupplypractices(GSP)药品供应管理规范gradientelution梯度洗脱grating光栅gravimetricmethod重量法Gutzeittest古蔡(检砷)法glassfunnellongstem玻璃漏斗gradcylinder量筒glassrod玻棒graduatedpipettes刻度吸管GC气相色谱Hheavymetal重金属halfpeakwidth平峰宽heatconductivity热导率heightequivalenttoatheoreticalplate理论塔板高度heightofaneffectiveplate有效塔板高度high-performanceliquidchromatography(HPLC)高效液相色谱法high-performancethin-layerchromatography(HPTLC)高效薄层色谱法hydrate水合物hydrolysis水解hydrophilicity亲水性hydrophobicity疏水性hydroxylvalue羟值hyperchromiceffect浓色效应hypochromiceffect淡色效应HHS-typeconstanttemperaturewaterbathHHS型恒温水锅HPLC高效液相色谱法Iidentification鉴别ignitiontoconstantweight灼烧至恒重immobilephase固定相immunoassay免疫测定impurity杂质inactivation失活index索引indicatorelectrode指示电极indicator指示剂inhibitor抑制剂injectingseptum进样隔膜胶垫instrumentalanalysis仪器分析injectionvalue进样阀insulinassay胰岛素生物检测法integrator积分仪intercept截距interface接口internalstandardsubstance内标物质Internationalunit国际单位invitro体外invivo体内iodide碘化物iodoformreation碘仿反应iodometry碘量法ionpairchromatography离子对色谱ionsuppression离子抑制ionsuppression离子抑制ionicstrength离子强度ion-pairingagent离子对试剂ionization电离isoabsorptivepoint等吸收点isocraticelution等溶剂组成洗脱isoelectricpoint等电点isoosmoticsolution等渗溶液irreversibleindicator不可逆指示剂irreversiblepotential不可逆电位KKarlFischertitration卡尔-费舍尔滴定Kjeldahlmethodfornitrogen凯氏定氮法Koberreagent 科伯试剂Kovatsretentionindex科瓦茨保留指数Llabelledamount标示量leadingpeak前延峰levelingeffect均化效应licensedpharmacist执业药师limitcontrol限量控制limitofdetection检测限limitofquantitation定量限limittest杂质限度试验lossondrying干燥失重lowpressuregradientpump氧压梯度泵linearityandrange线性及范围linearityscanning线性扫描luminescence发光litmuspaper石蕊试纸lyophilization冷冻干燥Mmainconstituent主成分make-upgas尾吹气maltolreaction麦芽酚试验Marquistest马奎斯试验massanalyzerdetector质量分析检测器massspectrometricanalysis质谱分析massspectrum质谱图meandeviation平均偏差meltingpoint熔点meltingrange熔距metabolite代谢物metastableion亚稳离子micellarchromatography胶束色谱法microanalysis微量分析microcrystal微晶microdialysis微透析migrationtime迁移时间Milliporefiltration微孔过滤mobilephase流动相molecularformula分子式monitor检测monochromator单色器monographs正文Nnaturalproduct天然产物Nessler’sreagent碱性碘化汞试液neutralization中和nitrogencontent总氮量nonaqueousacid-basetitration非水酸碱滴定nonprescriptiondrug,overthecounterdrugs非处方药nonspecificimpurity一般杂质non-volatilematter不挥发物normalphase正相normalization归一化法Nesslercolorcomparisontube纳氏比色管Onotice凡例octadecylsilanebondedsilicagel十八烷基硅烷键合硅胶odorless辛基硅烷odorless无臭officialname法定名officialtest法定试验on-columndetector柱上检测器on-columninjection柱头进样onthedriedbasis按干燥品计opalescence乳浊opticalactivity光学活性opticalisomerism旋光异构opticalpurity光学纯度organicvolatileimpurities有机挥发性杂质orthogonaltest正交试验orthophenanthroline邻二氮菲outlier可疑数据overtones倍频封oxidation-reductiontitration氧化还原滴定oxygenflaskcombustion氧瓶燃烧Ppackedcolumn填充柱packingmaterial色谱柱填料palladiumioncolorimetry钯离子比色法parention母离子particulatematter不溶性微粒partitioncoefficient分配系数patternrecognition(ppm)百万分之几peaksymmetry峰不对称性peakvalley峰谷peakwidthathalfheight半峰宽percenttransmittance透光百分率pHindicatorabsorbanceratiomethodpH指示剂吸光度比值法pharmaceuticalanalysis药物分析pharmacopeia药典pharmacy药学photometer光度计polarimetry旋光测定法polarity极性polydextrangel葡聚糖凝胶potentiometer电位计potentiometrictitration电位滴定法precipitationform沉淀形式precision精密度preparation制剂prescriptiondrug处方药pretreatment预处理primarystandard基准物质principalcomponentanalysis主成分分析prototypedrug原型药物purification纯化purity纯度pyrogen热原pycnometermethod比重瓶法plasticwashbottle洗瓶platformbalance天平pipette移液管pyknowmeterflasks容量瓶Qqualitycontrol质量控制qualityevaluation质量评价qualitystandard质量标准quantitativedetermination定量测定quantitativeanalysis定量分析quasi-molecularion准分子离子Rracemization消旋化randomsampling随机抽样rationaluseofdrug合理用药readilycarbonizablesubstance易炭化物质reagentsprayer试剂喷雾剂recovery回收率referenceelectrode参比电极relatedsubstance相关物质relativedensity相对密度relativeintensity相对强度repeatability重复性replicatedetermination平行测定reproducibility重现性residualbasichydrolysismethod剩余碱水解法residualliquidjunctionpotential残余液接电位residualtitration剩余滴定residuceonignition炽灼残渣resolution分辨率responsetime响应时间retention保留reversedphasechromatography反相色谱法reverseosmosis反渗透rinse淋洗robustness可靠性round修约reagentbottles试剂瓶roundbottomflask圆底烧瓶rubbersuctionbulb洗耳球Ssafety安全性Sakaguchitest坂口试验saltbridge盐桥saltingout盐析sampleapplicator点样器sampleapplication点样sampling取样saponificationvalue皂化值saturatedcalomelelectrode饱和甘汞电极selectivity选择性significantdifference显着性水平significanttesting显着性检验silicaget硅胶silverchlorideelectrode氯化银电极similarity相似性sodiumdodecylsulfate十二基酸钠solid-phaseextraction固相萃取solubility溶解度specificabsorbance吸收系数specification规格specificity专属性specificrotation比旋度specificweight比重spiked加入标准的splitinjection分流进样sprayreagent显色剂stability稳定性standardcolorsolution标准比色液standarddeviation标准差standardization标定standardsubstance标准品statisticalerror统计误差sterilitytest无菌试验stocksolution储备液stoichiometricpoint化学计量点storage贮藏straylight杂散光substrate底物substituent取代基sulfate硫酸盐sulphatedash硫酸盐灰分support载体suspension旋浊度swellingdegree膨胀度symmetryfactor对称因子systematicerror系统误差separatingfunnel分液漏斗stopcock玻璃活塞scissors剪刀spiritlamp酒精灯silicagelGthinlayer硅胶G薄层板Ttable片剂tailingfactor拖尾因子tailingpeak拖尾峰testsolution试液thermalanalysis热分析法thermalconductivitydetector热导检测器thermogravimetricanalysis热重分析法TheUnitedStatesPharmacopoeia美国药典ThePharmacopoeiaofJapan日本药局方thinlayerchromatography薄层色谱thiochromereaction硫色素反应thymol百里酚thymolphthalein百里酚酞titer滴定度three-dimensionalchromatogram三维色谱图titrant滴定剂titrationerror滴定误差titrimetricanalysis滴定分析法tolerance容许限totalash总灰分totalqualitycontrol全面质量控制traditionaldrugs传统药traditionalChinesemedicine中药turbidance浑浊turbidimetricassay浊度测定法turbidimetry比浊度turbidity浊度Uultracentrifugation超速离心ultravioletirradiation紫外线照射unduetoxicity异常毒性uniformdesign均匀设计uniformityofdosageunits含量均匀度uniformityofvolume装量均匀性uniformityofweight重量均匀性Vvalidity可靠性variance方差viscosity粘度volatileoildeterminationapparatus挥发油测定器volatilization挥发性volumetricanalysis容量分析volumetricsolution滴定液volumetricflasks比重瓶Wwavelength波长wavenumber波数weighingbottle称量瓶weighingform称量形式well-closedcontainer密闭容器whiteboard白瓷板XxylenecyanolblueFF二甲苯蓝FFxylenolorange二甲酚橙ZZigzagscanning锯齿扫描zwitterions两性离子Zymolysis酶解作用zoneelectrophoresis区带电泳。

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We study transport through a one-dimensional quantum wire of correlated fermions connected to semi-infinite leads. The wire contains either a single impurity or two barriers, the latter allowing for resonant tunneling. In the leads the fermions are assumed to be non-interacting. The wire is described by a microscopic lattice model. Using the functional renormalization group we calculate the linear conductance for wires of mesoscopic length and for all relevant temperature scales. For a single impurity, either strong or weak, we find power-law behavior as a function of temperature. In addition, we can describe the complete crossover from the weak- to the strong-impurity limit. For two barriers, depending on the parameters of the enclosed quantum dot, we find temperature regimes in which the conductance follows power-laws with “universal” exponents as well as non-universal behavior. Our approach leads to a comprehensive picture of resonant tunneling. We compare our results with those of alternative approaches.
1
arXiv:cond-mat/0411310v2 [cond-mat.mes-hall] 17 Jan 2005
Max-Planck-Institut f¨ ur Festk¨ orperforschung, Heisenbergstr. 1, D-70569 Stuttgart, Germany 2 Institut f¨ ur Theoretische Physik, Universit¨ at G¨ ottingen, Friedrich-Hund-Platz 1, D-37077 G¨ ottingen, Germany
I.
INTRODUCTION源自The interplay of static impurities and correlations in one-dimensional (1d) Fermi systems leads to a variety of surprising effects. A detailed understanding of the physics involved is interesting from the basic-science point of view as well as from the perspective of a possible application of 1d quantum wires in future nanoelectronics. In a 1d metallic system, correlations have a strong effect on the low-energy properties. Quite differently from the conventional Fermi-liquid behavior and even in the homogeneous case, physical properties at low energy scales follow power-laws, described by the Tomonaga-Luttinger liquid (TLL) phenomenology.1 For spin-rotational invariant and spinless models the exponents can be expressed in terms of a single number, the interaction-dependent TLL parameter K . A single static impurity in a TLL with repulsive interaction (0 < K < 1) leads to a dramatic modification of the low-energy physics as is obvious from lowest order perturbation theory in the strength of the impurity.2–5 More elaborate methods show that for vanishing energy scale s the conductance of such a system vanishes following a power-law.6–10 The scaling exponent 2αB is independent of the bare impurity strength and determined by the exponent αB = 1/K − 1 (for spinless fermions) of the one-particle spectral weight of a TLL close to an open boundary.6 For weak impurities the correction to the impurity free conductance scales as s2(K −1) , which holds as long as the correction stays small. Assuming an infinite system the asymptotic low-energy properties have been investigated intensively within an integrable field theoretical model — the local sine-Gordon model (LSGM).6–8,10 For this model, with fixed K the conductance as a function of temperature follows one-parameter scaling for different strengths of the impurity. Similar results were obtained for a TLL connected by arbitrarily “smooth” (spatially adiabatic) contacts to semi-infinite Fermi-liquid leads.11–16 Also transport through a double barrier enclosing a
Impurity and correlation effects on transport in one-dimensional quantum wires
T. Enss,1 V. Meden,2 S. Andergassen,1 X. Barnab´ e-Th´ eriault,2, ∗ W. Metzner,1 and K. Sch¨ onhammer2
quantum dot has been studied over the last few years using field theoretical models.6,17–27 Tuning the dot energies by a gate voltage Vg resonant tunneling can be achieved. For appropriately chosen dot parameters (dot size, barrier height) and as a function of temperature T the conductance G shows different temperature regimes with distinctive power-law scaling and exponents which can be expressed in terms of K .17,19–21,24–27 For the double-barrier problem no exactly solvable generic model is known and applying different approximate analytical17,19–21,24,25,27 and numerical26 methods has not provided a consistent picture. To study the effect of the interplay of correlations and impurities on transport on all relevant energy scales we use the functional renormalization group (fRG) method. The fRG can be applied directly to microscopic models. We consider the lattice model of spinless fermions with nearest-neighbor hopping t and nearest-neighbor interaction U . The impurities are modeled by either locally raising site energies or reducing hopping matrix elements across bonds. The fRG was recently introduced28 as a new powerful tool for studying interacting Fermi systems. It provides a systematic way of resumming competing instabilities29 and goes beyond simple perturbation theory even in problems which are not plagued by infrared divergences.30 The fRG procedure we use starts from an exact hierarchy of differential flow equations for the oneparticle irreducible vertex functions,31–33 as e.g. the selfenergy and the effective two-particle interaction. It is derived by replacing the free propagator by a propagator depending on an infrared cutoff Λ and taking the derivative of the generating functional with respect to Λ. At T = 0 we introduced earlier two truncation schemes which led to a manageable number of coupled equations.34–36 The flow of the self-energy, which in particular encodes the renormalized impurity potential, is fully taken into account, while the two-particle vertex is parametrized by a single flowing coupling constant.36 The bare two-particle interaction U is taken as a small parameter, but the impurities can have arbitrary strength and
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