On some non-holonomic sequences

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专题05 阅读理解D篇(2024年新课标I卷) (专家评价+三年真题+满分策略+多维变式) 原卷版

专题05 阅读理解D篇(2024年新课标I卷) (专家评价+三年真题+满分策略+多维变式) 原卷版

《2024年高考英语新课标卷真题深度解析与考后提升》专题05阅读理解D篇(新课标I卷)原卷版(专家评价+全文翻译+三年真题+词汇变式+满分策略+话题变式)目录一、原题呈现P2二、答案解析P3三、专家评价P3四、全文翻译P3五、词汇变式P4(一)考纲词汇词形转换P4(二)考纲词汇识词知意P4(三)高频短语积少成多P5(四)阅读理解单句填空变式P5(五)长难句分析P6六、三年真题P7(一)2023年新课标I卷阅读理解D篇P7(二)2022年新课标I卷阅读理解D篇P8(三)2021年新课标I卷阅读理解D篇P9七、满分策略(阅读理解说明文)P10八、阅读理解变式P12 变式一:生物多样性研究、发现、进展6篇P12变式二:阅读理解D篇35题变式(科普研究建议类)6篇P20一原题呈现阅读理解D篇关键词: 说明文;人与社会;社会科学研究方法研究;生物多样性; 科学探究精神;科学素养In the race to document the species on Earth before they go extinct, researchers and citizen scientists have collected billions of records. Today, most records of biodiversity are often in the form of photos, videos, and other digital records. Though they are useful for detecting shifts in the number and variety of species in an area, a new Stanford study has found that this type of record is not perfect.“With the rise of technology it is easy for people to make observation s of different species with the aid of a mobile application,” said Barnabas Daru, who is lead author of the study and assistant professor of biology in the Stanford School of Humanities and Sciences. “These observations now outnumber the primary data that comes from physical specimens(标本), and since we are increasingly using observational data to investigate how species are responding to global change, I wanted to know: Are they usable?”Using a global dataset of 1.9 billion records of plants, insects, birds, and animals, Daru and his team tested how well these data represent actual global biodiversity patterns.“We were particularly interested in exploring the aspects of sampling that tend to bias (使有偏差) data, like the greater likelihood of a citizen scientist to take a picture of a flowering plant instead of the grass right next to it,” said Daru.Their study revealed that the large number of observation-only records did not lead to better global coverage. Moreover, these data are biased and favor certain regions, time periods, and species. This makes sense because the people who get observational biodiversity data on mobile devices are often citizen scientists recording their encounters with species in areas nearby. These data are also biased toward certain species with attractive or eye-catching features.What can we do with the imperfect datasets of biodiversity?“Quite a lot,” Daru explained. “Biodiversity apps can use our study results to inform users of oversampled areas and lead them to places – and even species – that are not w ell-sampled. To improve the quality of observational data, biodiversity apps can also encourage users to have an expert confirm the identification of their uploaded image.”32. What do we know about the records of species collected now?A. They are becoming outdated.B. They are mostly in electronic form.C. They are limited in number.D. They are used for public exhibition.33. What does Daru’s study focus on?A. Threatened species.B. Physical specimens.C. Observational data.D. Mobile applications.34. What has led to the biases according to the study?A. Mistakes in data analysis.B. Poor quality of uploaded pictures.C. Improper way of sampling.D. Unreliable data collection devices.35. What is Daru’s suggestion for biodiversity apps?A. Review data from certain areas.B. Hire experts to check the records.C. Confirm the identity of the users.D. Give guidance to citizen scientists.二答案解析三专家评价考查关键能力,促进思维品质发展2024年高考英语全国卷继续加强内容和形式创新,优化试题设问角度和方式,增强试题的开放性和灵活性,引导学生进行独立思考和判断,培养逻辑思维能力、批判思维能力和创新思维能力。

Data Mining:Concepts and Techniques

Data Mining:Concepts and Techniques
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Types of Outliers (I)


Three kinds: global, contextual and collective outliers Global Outlier Global outlier (or point anomaly) Object is Og if it significantly deviates from the rest of the data set Ex. Intrusion detection in computer networks Issue: Find an appropriate measurement of deviation Contextual outlier (or conditional outlier) Object is Oc if it deviates significantly based on a selected context o Ex. 80 F in Urbana: outlier? (depending on summer or winter?) Attributes of data objects should be divided into two groups Contextual attributes: defines the context, e.g., time & location Behavioral attributes: characteristics of the object, used in outlier evaluation, e.g., temperature Can be viewed as a generalization of local outliers—whose density significantly deviates from its local area Issue: How to define or formulate meaningful context?

零日病毒传播模型及稳定性分析

零日病毒传播模型及稳定性分析

用背景,有针对性地引入新的节点状态或调整节点 状态转化机制对病毒传播机理进行研究[13-17]。如针 对高级持续性威胁(Advanced Persistent Threat, APT)攻击和病毒潜伏特性,王刚等人[13]引入了潜 伏状态,提出了易感-潜伏-感染-隔离-移除-易感 (Susceptible–Escape-Infected–Quarantine-Removed–Susceptible, SEIQRS)模型,研究了基于潜 伏隔离机制下的病毒传播规律。文献[11]通过研究 一类新型混合攻击病毒,将该类病毒命名为“去二 存一”病毒并在SEIQRS模型的基础上根据该类病 毒的扩散机理,构建了相应的病毒传播模型。Wang 等人[14]考虑到现有的病毒传播模型由于简化近似, 对大型网络中病毒传播分析造成准确性损失这一情 况,构造了离散时间吸收马尔可夫过程来精确地描 述病毒的传播,并通过仿真分析论证了该方法的准 确性。为了更加精准地刻画病毒在智能校园网上的 传播过程,Wang等人[15]考虑感染病毒个体间的差 异性,将病毒感染个体的进化过程扩展到整个网络 中,建立了智能校园网的病毒传播差分模型从而大 大提高了智能校园网的安全性与鲁棒性。文献[16] 在考虑级联故障普遍存在于复杂网络中的这一情 况,提出了基于局部负荷重分配原则的新型级联失 效模型,建立了SIR病毒传播与级联失效的交互模 型:SIR- c模型,为网络拓扑和路由策略的管理和 优化提供了理论参考。文献[17]考虑实际网络中节 点可以随机移动的情况,基于平均场理论提出了一 个移动环境下网络病毒传播的数学模型,并验证了 这一模型的合理性。这些研究揭示了病毒传播的一 般规律,为病毒的有效防控提供了理论基础。然而 不同病毒传播模型有其适用范围,零日病毒传播机 理相对复杂、隐蔽性强、防御难度大且破坏性大, 需要具体问题具体分析,在现有研究成果的基础 上,结合零日病毒特点研究零日病毒的传播规律及 防控手段。

2006_Colgate-The Cobotic Hand Controller Design, Control and

2006_Colgate-The Cobotic Hand Controller Design, Control and

The Cobotic Hand Controller:Design,Control and Performance of a Novel Haptic DisplayEric L.Faulring,J.Edward Colgate,and Michael A.PeshkinAbstract—We examine the design,control and performance of the Cobotic Hand Controller,a novel,six-degree-of-freedom, admittance controlled haptic display.A highly geared admittance architecture is often used to render high impedances with reasonable sized actuators for a haptic display.The Cobotic Hand Controller is an extremely faithful realization of an admittance display,since it is capable of obtaining an infinite gear ratio and can render infinite impedances(up to its own structural stiffness).The incorporation of continuously variable transmissions utilizing hardened steel elements in dry-friction rolling contact provide the Cobotic Hand Controller with high bandwidth,low power requirements,and an extremely wide stable dynamic range.Here we describe an admittance based control algorithm for powered cobots,a novel solution to the actuation redundancy of this device,and a heuristic to avoid slip in the transmissions.We measure the performance of the Cobotic Hand Controller in terms of dynamic range.Index Terms—haptics,admittance display,cobots,continu-ously variable transmission,traction driveI.I NTRODUCTIONA N increasing number of virtual environment and teleoper-ation tasks demand highfidelity haptic interfaces.These include interaction with computer aided design models,flight simulators,telerobotic surgery,micro/nano-manipulation,un-dersea salvage,as well as telerobotic maintenance and de-contamination and decommissioning of chemical and nuclear facilities.The execution of these tasks by a remote operator is affected by his/her level of telepresence and the transparency of the master-slave relationship[1].This illusion of presence is enhanced by audio,visual and haptic cues.While visual cues are certainly mandatory,and audio cues beneficial at times, haptic cues can significantly improve theflow of information from the environment to the operator for many tasks requiring dexterity.Haptic cues are impedances;relationships between motion and force that an operator encounters when interacting with a display.It is desired that the user perceive a high dynamic range including rigid constraints and unimpeded free motion.This paper introduces a novel display that improves transparency and presence by extending the range of cues (dynamic range)that can be rendered.The specific application for the development of the master hand controller introduced here is the teleoperation of the Dual Arm Work Platform(DAWP)at Argonne National Lab-oratory[2],[3].One of the key improvements the Cobotic Manuscript initially submitted March12,2006.Notification of acceptance on August24,2006.Revised and resubmitted on September4,2006.This work was supported by the DOE grant number DE-FG07-01ER63288.Eric L.Faulring is with Chicago PT,LLC(eric.faulring@).J.Ed-ward Colgate and Michael A.Peshkin are with the Department of Mechanical Engineering at Northwestern University(colgate,peshkin@).Hand Controller can provide to DAWP operation is the implementation of virtual surfaces,or virtual constraints on motion,as suggested by[4],[5],[6],[7].Such constraints can vastly simplify execution of a six-degree-of-freedom task in a teleoperation setting.While constraints can be implemented at the slave side in the existing system,an active master allows for the reproduction of these constraints at the master and may reduce operator fatigue while increasing efficiency by eliminating unneeded motions in six-space.Thus,if the operator is using a saw and constrains the motion of the saw to the plane of the blade at the slave,he/she feels these same constraints at the master.Rendering these constraints at the master also avoids time delay issues stemming from communication latencies.Existing haptic displays consist of admittance and impedance devices.Admittance displays are highly geared and therefore non-backdrivable while impedance displays have low inertia and are highly backdrivable.Admittance displays are reviewed in[8],[9],[10].The Haptic Master[11]and Steady Hand Robot[7]are notable implementations of the admittance paradigm.Although well-engineered admittance devices may have a higher dynamic range than impedance displays,they are rare due to cost and complexity.The required multi-degree-of-freedom force sensors,additional gears and bearings,and tight machining tolerances lead to significant cost.Thus the successful commercial haptic displays are often impedance devices.Impedance displays include the Phantom[12],the Whole Arm Manipulator(W AM)[13],and many others[14], [15],[16],[17],[18],[19].While today’s impedance and admittance displays may both be used to simulate a wide range of mechanical behaviors, they excel in different areas due to the nature of their control and mechanical structures.Among commercial and research devices,most serial link haptic displays have a maximum stable stiffness on the order of1-5N/mm(various models of the Phantom range in capability from1to3.5N/mm[20]) and most parallel haptic displays have an upper stable stiffness bound of15-50N/mm[14],[21].A stiffness of1N/mm is generally accepted as the minimum required to convey the presence of a constraint.Greater than24N/mm is required to convey the presence of a“hard”or“rigid”constraint[22]. Impedance displays can have an unmasked inertia as low as 0.05kg,while admittance displays typically have a minimum stable mass of2-5kg.Impedance displays are well-adapted to simulating low inertia,low damping environments,but have difficulty rendering energetically passive stiff constraints[23], [24].On the other hand,admittance displays are well-adapted to displaying rigid constraints but struggle to simulate un-Fig.1.Parallel cobotic transmission architecture.While there are six joint speeds that must be controlled for the Cobotic Hand Controller to render a virtual environment,there are six CVTs and a power cylinder(common element)that must be actuated.It is arbitrary at what speed to have the power cylinder moving since it is related via CVTs to the joints. encumbered motion.Unlike impedance displays,admittance displays must actively mask inertia and damping,which are their inherent physical behaviors due to their non-backdrivable transmissions.A.CobotsThe word cobot is derived from collaborative and robot, meaning shared control between a human operator and a computer[25],[26].Cobotic devices control the relative velocities of their joints by modulating continuously variable transmissions(CVTs)with small steering actuators(Figure1). Cobotic CVTs have been developed to relate two translational velocities,two rotational velocities,or a rotational velocity to a translational velocity,and have been used in many prototype devices[27],[28],[29],[30].The velocity ratios enforced by constraints in the transmissions cause cobots to have only a single mechanical instantaneous motion freedom,regardless of the dimension of their configuration space.The dynamics along this single instantaneous motion freedom defined by the CVTs are controlled via a single power injector in an active cobot such as the Cobotic Hand Controller,or by a human operator in the case of a passive cobot.Rolling constraints in the transmission elements,not electrical power,resist forces orthogonal to the current motion direction.The transmissions draw power from a single common element actuator as needed, potentially reducing the weight and power requirements of the overall ing a continuously variable cobotic transmission can eliminate the need to make compromises on outputflow and effort,which are inherent in choosing a fixed transmission ratio,and also allow the common element actuator to be operated at an efficient speed nearly all of the time.In addition,the cobotic architecture allows for the ability to both lock or decouple joints without any additional actuators beyond the single low-power steering actuator for each CVT.B.Summary of paperIn Section II we provide a detailed description of mechani-cal design of the Cobotic Hand Controller recently introduced by[31],[32].In Section III we review the computation of forward and inverse kinematics for the device.In Section IV we review the workspace,mechanism stiffness,force limits and the backdrivability of the device.In Section V,we summa-rize our virtual environment admittance control algorithm and outline the overall control strategy and low level controllers.A heuristic is developed that limits slip in the CVTs and therefore protects against instability of the display.In Section VI we derive a novel methodology for dealing with the actuation redundancy of the display.In Section VII we analyze the acceleration ability of the display.In Section VIII we analyze the dynamic range of the Cobotic Hand Controller.Finally in Section IX we provide conclusions and suggestions for future investigations.II.D ESIGNA.GeometryThe design of the six-degree-of-freedom Cobotic Hand Controller,shown in Figure2,utilizes the kinematics of a parallel platform introduced by Merlet[33],[34].The parallel platform portion of the geometry(i.e.,everything but the cylinder and wheels)has also been used in an ophthalmic surgery robot developed by[35]and,in a slightly modified form,in an industrial dextrous assembly robot called the Paradex[36].The proximal links are coupled by three-degree-of-freedom universal joints to the distal links,and these in turn are coupled via two-degree-of-freedom universal joints to an end-effector platform.Here a multi-axis force sensor is placed to measure the user’s intent.Our addition to Merlet’s kinematics is to relate the six linear actuators to a central power cylinder through non-holonomic rolling constraints.An alternative CVT design for a six-degree-of-freedom cobot was proposed by[37].Linear actuation of the proximal links is achieved by a rotational-to-linear continuously variable transmission(CVT), namely a steered wheel.The steering angle of each wheel relates the linear velocity,˙l i,of each proximal link to the rotational velocity,ω,of the power cylinder.A linearly moving carriage,shown in Figure3,couples each CVT wheel to each proximal link.When the wheels are steered such that their rolling axis is parallel to the power cylinder’s(φi=0),a ratio˙l i=−Rωtanφi=0is set.If the wheels are steered in either direction fromφi=0,ratios between±infinity can be achieved.In practice,wheel slip limits this range.It is also evident that turning all six wheels toφi=0locks the six actuators,and turning them toφi=π/2completely decouples the actuators from the cylinder’s velocity,although the cylinder would then be unable to turn.The cobot was designed for some degree of kinematicflex-ibility.Thus the offset clamps(Figure2)adjoining proximal and distal links have two attachment points for the distal links and can be rotated about the proximal links.Rotating them inward yields a larger rotational workspace but reduced stiffness.The mounting positions of the distal universal joints to the end-effector plate are adjustable as well.In addition,the length of the distal links is easily changed as they are made of threaded rod that inserts directly into the universal joints. The universal joints themselves are unusual in that they exhibit continuous rotation even when coupling shafts that are almost perpendicular(87.5degrees).This severe operationFig.3.In this figure,the motor driving the cylinder is explicitly shown.Two of the steering wheels are exposed.Carriages relating two other wheels to their proximal links are visible.angle would be detrimental if they needed to transmit power rotationally,but here they need only to transmit power through translation of the universal joint as they maintain a kinematic constraint.They were designed and built specifically for the Cobotic Hand Controller and each contains four preloaded radial bearings.As shown in Figure 4,the two ends of the device are capped by endplates which sit in v-groove rollers.Thus the whole device can be rotated and fixed by a locking pin at increments of 30degrees for maintenance or kinematic purposes.Each of the carriages can be removed independently if the proximal-distal offset clamp is detached.Wire management guides all wiring (not shown)through the rear endplate.The whole cobot can be turned upright and operated with the cylinder orientedFig.5.Top and bottom isometric views of a linear actuation assembly.vertically,although significant power (and a fraction of the preload at the wheel)would be consumed to move the joints against gravity.B.Joint assembliesThe parallel nature of the Merlet-Cobotic mechanism allows for six identical actuator assemblies.As shown in Figure 2,there are six equally spaced proximal links and actuator as-semblies.These assemblies,depicted in Figure 5and detailed in Figures 6-10,are bolted to a central core,detailed in Figure 11.All structural components are machined from aluminum with the exception of the proximal links.These are 15.875mm diameter ceramic tubes chosen for their high strength to weight and stiffness to volume ratios.The ceramic tubes at their current length provide 24cm of workspace along the axis of the cylinder.The upper limit of the workspace is limited by the cylinder’s 25cm length.The moving portion of each joint assembly (depicted in Figure 6)has mass m l =0.9kg.A conductive-plastic linear potentiometer (see Figure 7)was chosen as a continuous linear sensor over numerous digital incremental options due to its lightweight untethered wiper,as well as for the ability to perform analog differentiation of its output in order to obtain a high resolution velocity signal.Fig.7.Shown is one of six identical actuator assemblies.The proximal link is grounded to a carriage on a linear guideway.An Igus T Mflexible wire guide manages wiring for the steering motor and encoder.A ramp allows the carriage to be inserted between the guide-rods and cylinder,with the spacing decreasing gradually as the CVT wheel approaches the cylinder.This allows the application of a preload force by compressing springs within the steering bell(see Figure10).Although the circuitry and code were developed to interpret this analog differentiated signal,the signal-to-noise ratio is such that thefinite-differentiated and digitallyfiltered position signal yields an equally good velocity signal.Figure8details the linear guideway chosen.It was designed to minimize the friction in and construction tolerances required for the linear guideway.In addition,we desired to locate the CVT wheel,which is preloaded against the power cylinder, between the two guide rods in order to avoid requiring the guideway to resist significant moments.The resulting design utilizes two guide rods andfive rollers,four of which are aligned against one guide rod,thefifth against a second guide rod.The sixth point of contact,which constrains the carriage to one or zero degrees of freedom depending on the steering angle,is provided by the cobotic steering wheel.There are several key advantages of this non-of parallel or series,between the yoke of the CVT wheel and its housing.The spring-constant for this set of Bellevilles needs to be such that as the carriage travels from one end of the cylinder to another,minor changes in the length of the spring(±50µm)do not significantly alter the preload,since the preload will affect the dynamics of steering,linear motion control and cylinder control.Also mounted on the carriage is an optical encoder for measuring steering angle,a steering motor coupled via gears(2.33:1)to the steering bell and a wiper for a linear potentiometer(see Figure9).Designing wheels for use in cobots has always been problematic.Conflicting design goals when choosing wheel materials has limited wheel performance.It is desired that the wheels provide a high transverse frictional force with minimal preload,yet it is also desired that the wheels have low steering friction in order to allow for smaller steering actuators and higher bandwidth of control.It is also desired that the wheels have low rolling friction and little dissipation in order to provide for backdrivability and a reduced power requirement for powered cobots.The wheel should not have any compliance transverse to the rolling direction if a rigid transmission is desired.Finally the wheel material should incur minimal wear due to steering or rolling.Previous cobots have typically utilized polyurethaneFig.9.Carriage features.Each carriage relates a CVT wheel to a proximal link.It houses the steering motor which drives the steering bell assembly via a single-stage gear pair.An eccentric bushing allows fine adjustment of the inter-gear spacing.Fig.10.Steering bell features.The yoke supports the CVT wheel axle and is able to slide freely within the bell,guided by the brass bushings normal to the cylinder.If the distance between the linear guideway and cylinder changes over the stroke length,the Belleville springs absorb the change in position of the yoke while maintaining a preload.The wheel axle intersects the bell and causes the wheel to steer as the bell is driven by a gear pressed around it.Rollerblade T M wheels (75mm in diameter)in order to obtain the necessary transverse coefficient of friction.For the Cobotic Hand Controller we chose to move to harder wheel materials to increase the stiffness and bandwidth of the device,and to reduce rolling losses.Also,the linear guideways required the existence of a high preload (unnecessary for the high friction polyurethane wheels).With these two constraints in mind,steel wheels (18mm diameter)were chosen to run against a steel power cylinder even though the coefficient of friction of steel on steel is an order of magnitude less than that of polyurethane on steel.Depending on performance needs (transverse friction or resisting of wrenches on the guideway),more or less preload can be utilized.Currently the preload P is set to around 250N.The CVT wheels start out with a spherical profile and are the centers of plain spherical bearings with a hardness of Rockwell C 58.After a few hours of use,the wheels,originally with a black-oxide coating,have a shiny flat strip 880µm across.Even after 12months of intermittent use in the lab,the stripis no larger than 910µm across,which amounts to a total of 11µm of wear off the radius of the wheel.We find the coefficient of friction,µ,for support of lateral forces between the steel wheels and steel cylinder,to be around 0.12.This is the point at which lateral creep breaks down into gross slip.C.Power cylinderAs shown in Figure 11,the power cylinder is located between two mating blocks.The steel cylinder is 25cm in length,13.64cm in diameter,and has a 6.25mm wall thickness.The cylinder shell has been welded to its end-caps,and these to the shaft (total inertia of 0.0286kgm 2).The cylinder/end-caps/shaft were then hardened to Rockwell C 59.8and cylindrically ground between centers to a 12µinch finish.In 12months of use,the cylinder has not shown evidence of wear.Each of the six linear actuator assemblies bolt to the mating blocks.Also connected to the blocks are the power motor and a high resolution encoder.The motor is connected via a rigid coupling to the cylinder.A flexible coupling was originally present,but later removed to avoid unwanted resonances.A large 1200watt motor was chosen as it was readily avail-able in the lab and had sufficient torque to operate without gearing.The original goal of the large motor was to mitigate backlash,thus allowing smooth operation including reversal of direction,and to allow backdrivability if the system was ever operated passively.Ultimately,control algorithms were never implemented to take advantage of this feature,and preload and speed limitations have only allowed us to draw about 60watts of mechanical power from the cylinder motor,five percent of its capacity.Assuming we had a 70percent efficient gear-train between a much smaller motor and the cylinder,a motor capable of peaking at 86watts would have sufficed to drive the cylinder.D.Electronics and SoftwareTable I summarizes the specifications of the sensors and actuators.All motors are brushless DC operated in torque (current)mode.The linear position and force are recorded viaTABLE IS ENSOR AND ACTUATOR SPECIFICATIONS.Sensor LinearityPower Cyl Enc NA40,960cnts/rev2πLinear Pots1/200016bit ADC(2.5mN)±40N,±2Nm Actuator Cont TorquePower Cyl Motor 3.7Nm260mNm30a This oversized motor was chosen as it was readily available and eliminated the need for gearing and the associated backlash and nonbackdrivability. Ultimately control modes never took advantage of these features,and only 60mechanical Watts have ever been asked of the cylinder motor.16bit ADC boards.All the necessary electronics,including motor amplifiers and power supplies,the control computer,and signal conditioning hardware were placed in a single cabinet measuring41x46x53cm.The control computer is comprised of a1.53GHz standard personal computer running the QNX 6.2real-time operating system.An oscillator and counter, on one of three data acquisition boards,is used to generate hardware interrupts at approximately2000Hz,to which all data acquisition and output is latched electronically.Board IO and algorithms that run at the full2000Hz take about 60µs and220µs respectively.Writing data to disk,network communication and updating the GUI are performed at lower rates,and are lower priority threads.All code was written in C.III.K INEMATICSThe Cobotic Hand Controller has two discrete sets of kinematics,thefirst general to robotic devices and the second specific to cobots.Thefirst set of kinematics transforms between the SE(3)rigid body motion of the end-effector(task space)and the R6straight-line motion of the six proximal links (joint space).The second set of kinematics transforms between joint space and steering space,as a function of cylinder speed.A.Joint-to-task kinematicsLet us define as the joint-to-task forward kinematics of the parallel platform portion of the Cobotic Hand Controller as the functions,ϑ(l),that take us from joint space coordinates, l,to task space coordinates,x=ϑ(l),(1) of the manipulandum(end-effector).The Jacobian,J,relates motion in joint space,˙l,to motion in task space,˙x.˙x=J(l)˙l J(l)=∂ϑ(l)∂xis easily establishedfrom the expressions l i=ϑ−1i(x),and relates velocities˙l and˙x.˙l=J−1(x)˙x J−1ij(x)=∂ϑ−1i(x)∂x j∂x k(4)¨li=6j=1J−1ij(x)¨x j+6j=16k=1H−1i,jk(x)˙x k˙x j2)Forward kinematics:For the general case of a six-degree-of-freedom parallel manipulator,if no pairings(in-tersections of axes of universal joints)exist at the platformor base,a closed form analytical solution is not availablefor the forward kinematics.In fact,twelve solutions arepossible for task space coordinates for a given set of jointcoordinates without using any heuristics about collisions orrange of motion.In practice,a Newton-Raphson iterativescheme can be used to compute the task space coordinates,x,given measured joint coordinates,l,and an initial estimatefor the task space coordinates,x o.However,it will becomeapparent that knowledge of the actual task space coordinates isunnecessary and the Newton-Raphson scheme is not needed.The Cobotic Hand Controller tracks a desired trajectory intask space and we map this desired position,velocity andacceleration to joint space.This is done by utilizing a Jacobianand Hessian computed from the desired task space location.Then our feedback control is implemented in joint space.Thuswe do not need to map the actual joint space location to taskspace via a Newton-Raphson scheme.B.Steering-to-joint kinematicsLet us define as the steering-to-joint forward kinematics ofthe continuously variable transmission portion of the CoboticHand Controller as the functions that take us from steeringangle,φi,and cylinder speed,ω,to joint space velocity,˙l i.1)Forward kinematics:The input and outputflows for eachrotational-to-linear transmission are related via˙liFig.12.Translational workspace without allowing rotation.The workspace is best approximated by an8cm radius hemisphere stacked on top of a 16cm diameter,13cm long cylinder,oriented along the x3direction(see Figure4for the coordinate directions).Thus the workspace has a relatively flat bottom and a domed top.The three-fold symmetry of the proximal-distal link connection points is apparent in the grooves on the bottom,and in the slightly hexagonal shape of the cylinder and dome.2)Inverse kinematics:During operation of the display, we seek to control joint motion,and thus the appropriate steering velocities are computed given the commanded joint accelerations.We differentiate Equation5and obtain˙φi =−¨li+R˙ωtan(φ)τc=−1Fig.14.Forces from cylinder acting on the wheel at the contact patch. and are diagrammed in Figure14.f w,i is the net force applied by the cylinder on the wheel in the joint direction.τc is the cylinder torque acting on the wheel.Here we have neglected the effort losses due to rolling friction in the transmission and the CVT wheel axle bearings which we model in[38]and[39]. The output force of the joint at the wheel,f w=m l¨l+c d,l P sgn(˙l)−f l,(8) is composed of the inertial force of the joint,m l¨l,the joint friction force,c d,l P sgn(˙l),and the net output force of the joint,f l(the operator applied force).c d,l is the linear guideway dynamic coefficient of Coulomb friction.For preload force P set to250N,joint friction c d,l P sgn(˙l)is0.84N.The joint masses m l are0.9kg.Forces in the longitudinal(rolling direction)of the wheel are essentially zero,unless the wheel is accelerating,or experiencing rolling friction.The net lateral force,f w secφ, is of primary concern.Adequate lateral friction force,µP, must be present so thatµP≥f w secφ.(9) When this is satisfied,adequate friction force is available to accelerate the linear carriage,to combat joint friction and to apply the net force,f l,to an operator.With all transmissions steered toφ=0,thus attaining their maximum available lateral friction forcesµP/sec(φ)=30N,the combined six joints of the Cobotic Hand Controller can sustain task space loads of≥50N without the expense of any electrical power.D.BackdrivabilityHere we examinefirst the inertial forces and then the friction forces that a user feels when attempting to backdrivea passively operated Cobotic Hand Controller.1)Apparent inertia:Due to the rolling constraints in the transmissions,the cobot only has a single motion freedom for a given set of steering angles,and the apparent inertia of the cobot along this single motion freedom incorporates the six joint masses as well as the cylinder inertia,in some combination depending on the transmission ratios.The lowest the apparent inertia could be in the translational direction along the cylinder’s axis is6m l=5.4kg,the sum of the six joint masses,plus the steering angle dependent contribution of the cylinder inertia which can be zero forφ=πr sin(φ)for each wheel,where r is the radius of a CVT wheel andτw,fr the rolling friction torque from inelastic losses at the wheel-cylinder interface and the friction in the wheel axle bearings.The joint frame force needed to backdrive the cylinder bearings isτc,fr2 such that the cylinder does not spin,an operator would haveto apply effort5.7N in order to backdrive the six joints.If the wheels were steered atφ=π。

微卫星单碱基的英语

微卫星单碱基的英语

微卫星单碱基的英语英文回答:Microsatellites are short, repetitive sequences of DNA that are composed of a single nucleotide, such as A, C, G, or T. These sequences are found throughout the genome and are often located in non-coding regions. Microsatellites are highly polymorphic, meaning that they vary in length between individuals. This polymorphism makes them usefulfor a variety of genetic applications, such as population genetics, forensic science, and paternity testing.The most common type of microsatellite is the dinucleotide repeat, which consists of two nucleotides repeated in tandem. Dinucleotide repeats are typically named after the two nucleotides that they are composed of, such as AC, AG, or AT. Other types of microsatellites include trinucleotide repeats, tetranucleotide repeats, and pentanucleotide repeats.Microsatellites are thought to arise through a process called replication slippage. This process occurs when DNA polymerase pauses during replication and repeats the same nucleotide several times. Microsatellites can also be created or lengthened through a process called unequal crossing-over. This process occurs when two homologous chromosomes misalign during meiosis and exchange genetic material.Microsatellites are highly polymorphic because they are prone to mutations. These mutations can occur through a variety of mechanisms, including replication slippage, unequal crossing-over, and gene conversion. Microsatellite mutations can have a number of different effects, including changes in gene expression, changes in protein structure, and changes in disease susceptibility.Microsatellites are a valuable tool for a variety of genetic applications. They are used in population genetics to study the genetic diversity of populations and to track the flow of genes between populations. Microsatellites are also used in forensic science to identify individuals andto link suspects to crime scenes. Microsatellites are also used in paternity testing to determine the biologicalfather of a child.中文回答:微卫星是长度较短的重复性 DNA 序列,由单个核苷酸组成,如A、C、G 或 T。

分子生物学常见名词解释(中英文对照)

分子生物学常见名词解释(中英文对照)

分子生物学重要概念AAbundance (mRNA 丰度):指每个细胞中mRNA 分子的数目。

Abundant mRNA(高丰度mRNA):由少量不同种类mRNA组成,每一种在细胞中出现大量拷贝。

Acceptor splicing site (受体剪切位点):内含子右末端和相邻外显子左末端的边界。

Acentric fragment(无着丝粒片段):(由打断产生的)染色体无着丝粒片段缺少中心粒,从而在细胞分化中被丢失。

Active site(活性位点):蛋白质上一个底物结合的有限区域。

Allele(等位基因):在染色体上占据给定位点基因的不同形式。

Allelic exclusion(等位基因排斥):形容在特殊淋巴细胞中只有一个等位基因来表达编码的免疫球蛋白质。

Allosteric control(别构调控):指蛋白质一个位点上的反应能够影响另一个位点活性的能力。

Alu-equivalent family(Alu 相当序列基因):哺乳动物基因组上一组序列,它们与人类Alu家族相关。

Alu family (Alu家族):人类基因组中一系列分散的相关序列,每个约300bp长。

每个成员其两端有Alu 切割位点(名字的由来)。

α-Amanitin(鹅膏覃碱):是来自毒蘑菇Amanita phalloides 二环八肽,能抑制真核RNA聚合酶,特别是聚合酶II 转录。

Amber codon (琥珀密码子):核苷酸三联体UAG,引起蛋白质合成终止的三个密码子之一。

Amber mutation (琥珀突变):指代表蛋白质中氨基酸密码子占据的位点上突变成琥珀密码子的任何DNA 改变。

Amber suppressors (琥珀抑制子):编码tRNA的基因突变使其反密码子被改变,从而能识别UAG 密码子和之前的密码子。

Aminoacyl-tRNA (氨酰-tRNA):是携带氨基酸的转运RNA,共价连接位在氨基酸的NH2基团和tRNA 终止碱基的3¢或者2¢-OH 基团上。

顺磁纳米颗粒经AEAPS及Dextran生物修饰后标记MSCs

顺磁纳米颗粒经AEAPS及Dextran生物修饰后标记MSCs
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科技英语简介课件

科技英语简介课件
Usage: In scientific literature and academic exchanges, the use of abbreviations is very common, which can simplify complex terminology and improve communication efficiency.
• Progress in science and technology: STE is critical for the progress of science and technology as it enables professionals to keep up with the latest developments in their fields and to contribute to the body of knowledge
01
Overview of Science and Technology
English
Definition and characteristics
Denology English (STE) is a subset of English used in the field of science and technology It is a specialized language that is unique to this domain, and it is used to communicate scientific and technological information
English • Technical English Translation Skills
• Writing Standards for Science and Technology English

同等学力申硕英语模拟题答案

同等学力申硕英语模拟题答案

Paper onePart I Dialogue CommunicationSection A1.选A..在语言学中有一种“使役行为理论”;指的是有些句子具有一定的使役力量;虽然没有直接提出要求;但听者听了以后会觉得说话者间接提出了某种请求;让听者做某件事..在这里;A方虽然表面是在问B方是否靠近门口;但其前提是感到寒冷;可见其目的并不只是单纯的询问B方所处的位置;而是间接地请求B方把门关上;所以选项A实现了成功的交流目的.. 2.选B..A方问:“最新的一期时代周刊到没到今天已经是星期二了..”选项B的答复最合理:“这杂志晚了..也许后天才能到..”其他几个答复均不合适..如干扰项A仅重复了杂志未到的事实;无任何新信息..3.选A..注意本对话讲的是打电话投硬币的事..A方是电话提示;要求投入更多预付金硬币;否则通话就无法继续了..因此;选项A说:“噢;天哪;我没钱了..得把电话挂了..”4.选B..A方问:“Ray;你放学后不直接回家吗”选项B说:“不..我1点钟还要上课;然后在图书馆待几个小时再回家..”干扰项A可能起作用..但应注意;按照英语的习惯;当回答内容为否定时;其前不能使用Yes..5.选A..A方说:“听说你得了一张停车罚单..”选项A的意思是:“是啊;我根本不知道3区是专供教师用的..”Lot在此指停车的分区..Section BDialogue Comprehension6.选A..女士问男士是否见过凯莉在附近出现;男士回答说;凯莉的手提包就放在椅子上;暗示凯莉很可能就在附近..7.选A..男士提醒女士记得去看医生;但女士说只是有点擦伤;暗示她认为情况并不严重;不需要去看医生..8.选B..pick up在这里的意思是“学某种东西”..on one’s own的意思是“靠自己”..知道了这两个词组的意义;就很容易选出答案B..9.选D..这道题的关键词是resume;即“简历”..女士打算给这家电力公司递上一个简历..显然;她是想在这家公司工作..10.选C..男士说他打算放弃拉小提琴;因为管弦乐队再次拒绝接收他为成员;女士对此表示怀疑:“仅仅因为你没能成功考入乐队;难道就此放弃吗”可见她希望男士应重新考虑他的决定..“make”在这里指“成功作成某事”..Part II V ocabulary11.选B.mended:赞扬;表彰;其对应词应为praised;即“表扬;表彰”..本题题意为:那位消防队员因其在熄灭那场大火的勇敢表现而受到表彰..辨义:A.denounced斥责;C.welcomed 欢迎;D.exclaimed嚷叫起来;大声叫..12.选C..画线词rule out:排除掉;其对应词应为exclude;即“排除掉;不包括..”本题题意为:我们无法排除是他的妻子将他杀害的..辨义:A.foresee预见;B.run out用完;D.foretell 预言..故答案为C..13.选A..画线词back up;在这里的意思是:依靠;支持;其近义词为A support..辨义:A support 支持..辨义:通过语义判断;到分辨词汇可分辨义:A.elevate;B.提高;C.investigate调查;D.challenge挑战..本题题句的意思为:人们期待着科学家们做出彻底的研究来支持对这些新药所作的断言..故正确答案为A..14.选D..画线词baffling在此的含义是:令……惊讶;或令人感到茫然莫解..其对应词为perplexing to..本题题句的意思为:有一类侦探小说描述令人钦佩的业余侦探;他们通过理智地分析犯罪动机与线索;侦破了一些使警察困惑不已的案子..正确答案为D..辨义:A.revealed by由……揭示出;B.predicted by由……预测;C.alarming to对某人产生提醒或告诫的作用..15.选A..画线词的对应词为:fundamentally..二者共同的基本意思是:基本上、聪根本上..本题题句的意思为:相对论基本上有两部分组成:狭义相对论和广义相对论..辨义:B.usually 通常;C.frequently经常;D.approximately大约、近似地..16.选C..画线词depicting:描绘..其含义与portraying描绘;绘制接近..本题题意为:描绘风景景观的刺绣18世纪末就在美国开始畅销起来..辨义:A.stating陈述;B.relating论及;D.celebrating庆祝性的..故答案为C..17.选A..画线词daring意为辨义“大胆的、勇敢的;”bold是其同义词..本题题句的意思为:那个胆大的年轻人骑马穿过那印第安人的村庄试图找到他那走失了很久的妹妹..辨义:B.cowardly怯懦的;C.persistent坚持不懈的;D.caring关心人的..18.选D..Did you suspect that the entire episode was an elaborate deception这句话的意思是:你可曾想到整个段落情节是一个精心设计的骗局句中画线词deception的意思是“欺骗..”其含义与选项D.hoax相近..故D为正确答案..辨义:A.decision决定;B.death死亡;C.invitation 邀请..19.选C..画线词defect是B.effect.的反义词;C.weakness的近义词..本题题句的意思是:对自己的能力缺乏信心是迈克个性中的一个主要弱点..正确答案为 C..辨义:其他词的含义是:A.defeat战胜、击败;D.device设计、装置..20.选B..画线词defy的意思为:不顾;不予理睬..与选项B.oppose “反对”为同义词..本题题句的意思为:约翰继续反对他的老板..辨义:A.avoid避免;C.admire赞赏、敬佩;D.guide指导..Section B21..选 A..填词题的做题窍门在于先要读懂题意..本题题句Numerous experiments have demonstrated that mass is_____ to energy的意思是:无数的实验已经证明;质量可以转换为能量..需要填全的词必定得是一个含义与句意相通的形容词..在这里就应当是选项A.convertible;即“可转换的”..辨义:B.exchangeable可交换的;C.transplantable可移植的;D.conceivable可相信的;可设想出来的..22.选A..本题题句In October of this year our Party will_____ its Thirteenth National Congress 的意思为:今年十月我们党要召开十三大了..在这四个选项中;只有A.convene表示“召开”之意..故为正确答案..辨义:B.assemble集合;C.gather集中;D.meet会面..23.选B..本题题意为:自从20世纪30年代早期;瑞士银行就以自己的保密体系和带密码的存折而自豪..在其4个选项中;只有pride;表示“以……自豪;使自豪;使自夸等”..其固定搭配为pride oneself on something;“以……自豪”..做名词时固定搭配为take pride in something..故答案为B..24.选B..本题题意为:传统上从来不让外国学生久留和工作的国家;如德国和英国;在信息技术方面都面临着劳动力_____ 缺乏的问题;因而放松了移民法..A.cuts“裁减;”B.shortages “短缺;”C.weaknesses“弱点;”D.imports“进口..”故答案为B..25.选C..本题题句A series of _____scandals led to the fall of the government的意思为:一系列贪污腐化事件导致政府垮台..C. corruption的意思是:“腐败;道德败坏..”应为正确选项..辨义:A.degradation贬职、降级;B.degeneracy衰退、退化、破坏;D.subversion颠覆.. 26.选A..本题题句Could you possibly_____ me at the next committee meeting的意思是:你能否在下一次会议上塞鲎我一下本句中要求判断出一些读短语动词的用法来..辨义:A.stand in for sb.“站在……的一方”..辨义:B.make up for弥补;补足;C.fall back On求助于;D.keepin with继续与某人保持友好..根据句意;A为正确答案..27.选C..本题题句The old scientist decided to move to his country home _____ his advanced age and poor health.的大致意思应当是:考虑到年事已高;健康状况不佳;这位老科学家决定搬回农村居住..句中缺少的部分应表示原因..选项C.on account of考虑到;由于;因为就应是首选..辨义:A.in the interest of由于对……的兴趣;B.as a result of由于……的结果;D.in support of支持;拥护..28.选B..本题题句_____ of the financial crisis;all they could do was hold on and hope that;things would improve的意思是:鉴于_____ 到金融危机的了顶点;他们所能做到的就是忍耐并希望事情有所好转..句中的空缺处填上……的定点..即B.At the height;在……的顶点..其他词义辨义:A.At the bottom“在……的低谷”;C.on the top “在……的顶部”;D.In the end最终..故根据句意;B为正确答案..29.选A..本题题句Bill looked everywhere for his dictionary but _____ had to return home without it.的意思是:比尔到处找自己的字典;但_____ 最后不得不空手而归..辨义:A.in the end“最后;终于”;B.at the end;一般用做at the end of;意思是“在……结尾;在……末端”;C.in the finish不是短语;正确的短语应为at the finish;意思是“在最后”;D.at the last也不是短语;正确的短语应为at last;意思是“最后”..故根据句意;A为正确答案..30.选A..本题题句We are prepared to overlook the error on this occasion _____your previous good work的意思是:我们已准备_____ 按照你先前做出的卓越研究来考察在这种情况下可能出现的错误..辨义:A.in the light of鉴于;由于..其意正合题意语境的需要..B.thanks to多亏;幸亏;C.with a view to着眼于;以……目的;D.with regard to关于..因此;句意显示A为正确答案..Part III Reading ComprehensionPassage 0ne短文大意本文讲述了the Robotic Rover Spirit机器人海魂号对火星一岩石样本的取样后;科学家对它进行的研究..题目精解31.选B..本文第一段末句即指明the robotic rover Spirit began investigating the rock用的是with two science instruments and a microscopic camera.32.选D..这是一道文句大意重述题..因为they were glad to see the results就等于说But they were...pleased;而后半句and puzzled over the soil test results就等于说他们对这些土壤的特征还感到无法理解;也就等于说they can’t explain them..因为puzzled over的意思就是“对……迷惑不解..”33.选C..本文第六段Olivine第一次出现后;即用一个非限定性定语从句对其进行解释:which contains oxygen.iron and magnesium;is often found in volcanic rocks.由此可知正确答案为C.. 34.选A..本题定位在第五段:X-rays emitted by the surface soil indicated a chemical composition mainly of silicon and iron;with smaller amounts of sulfur;chlorine and argon.35.选B..本题定位在全文末段末句:Nothing collapsed;leading Dr.Squyres to ask what force was responsible for holding them together.36.选D..本文首段指出the robotic rover Spirit开始在火星上研究一块岩石样本;接着展开叙述科学家对它的研究..Passage Two短文大意本文介绍了鸟类鸣声随所在地域不同而有所不同的特性;并通过Kroodsma大体介绍了这种差异形成的原因..题目精解37.选A..从本文第二段中Birds that live on the boundary between two dialects or that spend time in different areas can become“bilingual”定位..38.选C..题干定位在第二段倒数第二句rapid cultural evolution within each generation紧接着说明This kind of song evolution is found in whales but;up until now; rarely in birds.39.选D..在第四段对话中;With these birds;if we find differences in their songs from place to place;it means that the DNA has changed too;表明选项A是正确的;这段对话的末句you get these striking differences from place to place because the birds have learned the local dialect说明选项C是正确的;综合两个选项;选择D..40.选C..猜测词义题..题干出现在SA的第三次发问中.;通过阅读DK的回答;because they are thrown together with different birds every few months from all over the geographic range;可知答案为C..41.选B..题干出现在全文末句;是一个由wish引导的虚拟句;可知DK在目前还不知道这个答案;故应选B..42.选C..本题属定标题..从最后一段引述DK的话;即“So I think for nomadic birds like Sedge Wrens;because they are thrown together with different birds every few months from all over the geographic range;they don’t bother to imitate the songs of their immediate neighbors They make up some kind of generalized song;or rather the instructions in their DNA allow them to improvise this very Sedge Wren-y song.”可以看出这篇对话的主旨是研究鸟的呜声与其所处的地理环境及其邻居的关系的..Passage Three短文大意耶鲁大学的物理学家Robert Adair指出;在棒球运动中;外野手如果想准确地接着球就不能仅仅依靠视觉信息;而必须根据球击在木质球棒上的声音来及早判断球会飞行多远..题目精解43.选A..具体细节题..解题的信息在第2段第2句话:If he relied purely upon visual information;the fielder would have to wait for about one-and-a-half seconds before he could tell accurately if the pitcher hit the ball long or short.44.选A..第3段中有这样的描述“If I heard a crack I ran out...”防守队员向外跑;说明击球手击出的是一记长球..45.选C..具体细节题..见第5段第2句话:Balls hit on the sweet spot generate fewer energy-sapping vibration in the bat;allowing greater energy transfer t0 the ball.46.选C..Adair在最后一段指出;铅质球棒无论球击在何处发出的都是同样的一声“呼”.. 47.选B..在第一段第一句就提到;“Experienced baseball fielders can tell how far a ball is going to travel Just by listening to the crack of the bat.If they didn’t;they wouldn’t stand a chance of catching it”;有经验的棒球外野手可以通过倾听球拍的击打声来分辨球的运动距离;而无法做到这一点的话;则有可能把握不住接球的机会..所以A是正确的..在第二段提到;“If he relied purely upon visual information...the ball may have traveled too far for him to each it in time·”所以B不正确;应该为visual而不是sound information..第三段中;“The difference between the crack and clunk...could mean a difference in running distance of as much as 30 meters”;所以C 正确..第四段最后一句提到;“Conversely;mishit balls make the bat vibrate strongly and SO donot travel as far.”相反地;如果没有击中sweet spot的话;会使拍子剧烈振动;从而无法击得远;所以D也正确..48.选B..主旨大意题..本文主要讲的是防守队员如何根据球击在木质球棒上的声音来判断球的飞行距离..Passage Four短文大意本文虽然一开头就介绍宇宙学家和星源学家之间的不同之处;但此后都是围绕着星源学家内部对于太阳系起源所持的不同见解展开的..题目精解49.选C..本文讨论的是星源学家之间的争论;关于太阳系的形成根源究竟是否同一物质..所以应该选C最为接近..50.选D..本文第1段提到;1848年Edgar Allen Poe在一次演讲中提到了星源学的奥秘;但不能因为他作过一次演讲就断定他是cosmologist或cosmogonist或lecturer..本题的解题信息在in a new edition of Poe’s prose poem Eureka.51.选C..具体细节题..见第2段第3旬:Cosmologists worry about where the Universe came from;cosmogonists with how the Solar System formed.52.选A..选项A中的completely与文章的内容不符;因为Mercury和Pluto不在这一平面上.. 53.选B..从本文的第4段可以了解到;大多数星源学家把太阳有7.25度倾斜度这一事实归因于太阳物质的损失:Anyway;they add;the Sun has been losing mass for most of its life and may have slipped a little:54.选C..第6段中的Not at all暗指一个倾斜的太阳并不是星源学家们唯一头痛的事情;应该还有许多令他们头疼的事情..Passage Five短文大意本文描述的是目前由于俄罗斯太空急救飞船的承载能力的限制;目前国际空间站的永久成员只能是3个;他们整天忙于空问站的运行与维护;基本上无法进行有益的科学试验..因此美国的NASA正计划利用其他办法增加太空站的人员编制..题目精解55.选C..推断引申题..本文第1段的最后一句中will at last be able to do useful scientific research这一部分暗示目前的3人编制根本无法进行科学试验..56.选A..具体细节题..解题的信息在第2段第一句中的limited by three by the capability of Russian Soyuz capsules that would return them to Earth in an emergency.57.选C..capsule在文中是指太空舱;跟cabin机舱的意思较为接近;所以选C..58.选B..具体细节题..见第3段第2句:But faced with a$5 billion budget overrun;the agency cancelled the project last year..59.选B..本文在第5段描写到;俄罗斯同意把Soyez的使用寿命延长到2006年;但从2006~2010年间国际太空站将没有救生飞船;因此也不会有永久人员..这是a big problem o60.选D..主旨大意题..综合各段的主题句的意思可以看出;本文主要是阐述如何增加国际太空站的人员编制;进行有用的科学研究..Part IV Cloze短文大意本文介绍“否决”..文章通过介绍否决的定义、适用范围、一般规则以及历史上美国总统与国会使用否决权的实例;阐述了这个问题..这一主题在段首句与段尾句中得到了明确的反映..段首句大意:vet0这个英语单词的意思是“我不允许”..开门见山;道出文章的主题..段尾句大意:这些提案中至少有一条已经被他否决了..以下详细讲解各题答案..题目精解61.选B..本题考理解..考生应能读懂本文的第二句是对第一句中“I will not permit”的解释..permit意为“允许”;因此;可知本题词义为“阻止、阻挠”..进一步参照选择项;则可发现A.accept:意为“接受”;C.promote意为“促进、推进”;D.challenge意为“挑战”;B.block 意为“阻挡、阻止”..只有B.block符合veto的含义;是本题正确答案..62.选A..本题考词汇..根据我们对联合国安理会的了解;我们知道联合国安理会是由中、美、英、法、俄五个常任理事国组成;显然;本题词义应为“由…组成”或“包含”..仔细区分四个选择项的差别;发现只有A.has符合文章要求..即联合国安理会有五个常任理事国..干扰项词义:B.consist与D.is made up都含有“由……组成”或“包含”之意..不过;选择项中所给的短语搭配不全..完整的短语形式应该分别为consist of和is made up of..因此;这两项可以排除..C.maintain意为“保持”或“持…观点”;也不符合文章的语意要求..63.选D..从语法角度分析;本题答案为该句主语..根据前文及常识;可以知道在此充当主语的为上述五国..然后根据选择项一一排查..Both意为“两者都”;用来表达双方的情况;但是;此处有五个国家;因此可以排除选择项A..B.All of which虽然可以用以表示“其中所有的”;但通常用于非限定性定语从句句首;而此处为独立的句子;并非从句;因此选择项B.也可排除..C.Ever..y也可以代表全体;但它是形容词;不能做主语..D.Each为代词;意为“每个”;满足了语法和词义两方面的要求;是本题正确答案..64.选B..本题考动词短语辨析..无论单词辨析还是短语辨析;都要以对文章的正确理解为主要依据..A.calling off意为“取消”;C.calling upon意为“号召、召唤”;calling up意为“打电话”;B.calling for意为“要求”;是本题正确答案..本句大意是;英法两国否决了一项要求以色列从埃及领土撤军的议案..65.选D..本题考近义词辨析..根据常识;可以判断此处需要一个形容词;表示“平常的、通常的、普通的”;修饰use..A.normal“正常的、规范的”;不符合文章要求;可以首先排除..由于其他各项的中文释义都带有“一般、普通的”含义;需要进一步辨别它们之间在语义侧重上的细微差别..B.ordinary质量、品质“一般化、普通”;针对特殊的或特别实例而言;即“没有什么特别之处”的意思;C.average指中等水平的;针对较高或较低水平而言“不高不低”;Dmon“平常的、通常的”;针对事情发生的频度而言;即“常见的”之意..66.选D..本题考语法..选择项提供了动词的四种形式..在甄别正确答案时;应考虑使用谓语或非谓语动词;即选择A或D;还是选择B或C;现在时还是过去时;即:选择A或C还是B;以及单数即选择项D或复数动词即选择项A几个方面..首先;显然应选择谓语动词形式;即排除现在分词选项C.providing for..然后排除过去时选项B.provided for;因为文章所谈论的是美国现行宪法..最后;由于主语“美国宪法”是单数;故再排除A.provide for;正确答案为D.provides for..67.选C..本句紧接前句..根据副词aIso也的提示;本句仍然讨论同一个话题;主语也仍然是美国宪法..故正确答案为C.Const;itution..68.选C..本题考序数词的拼写形式..C.tWO—thirds为唯一的正确答案..69.选B..本题考情态动词的用法;而情态动词的选择主要取决于对文章的理解..此处讲述的是:在总统使用否决权后;国会议案成为法律的先决条件是两院都必须投票推翻总统的否决..作为立法程序;此处需要用明确、强硬的情态动词来描述;因此答案为B.must;即“必须”..干扰项A.may和C.can都表示可能性;D.will则表示“将会”之意..70.选C..本题考时态..在谈到历史上的美国总统多次否决国会提案的问题时;没有明确的时间状语;显然本句信息的焦点在于总统否决国会提案的影响与后果..况且紧随其后的句子也用了现在完成时;支持了本题应该使用现在完成时的判断..71.选C..本题考副词的应用..对副词的选择主要基于对文章的理解..如上所述;美国历史上总统曾否决过2 500个国会议案;而国会否决总统的否决则只有104次..两个数字如此悬殊;可见;形容国会否决总统次数的副词应该是C.0nly;意为“仅仅”..干扰项词义:A.possibly“可能”;B.even “甚至”;D.simply“简单地、只不过”..72.选D..本题考固定用法..从四个选择项分析;此处所要的词义应该是“后期、晚期”;即“18世纪后期”..英语中对晚期或后期的表达用te和early用法举例:He was born in the late 1950s and was in his early for’ties when he star..ted the shoe business.他出生于20世纪50年代后期..在他开始经营制鞋业时已经四十出头了..73.选D..本题考语篇理解能力..需填写词为动词;所带宾语为the size and cost of the federal government;即联邦政府的规模及其开支..问题在于此处指“扩大”还是“削减”政府的规模或开支..答案可以从下文中得到:在陈述Clinton总统观点时用了cut一词;即“削减”..可见此处当填D.reduce..干扰项词义:A.change“改变”;B.maintain“保持”;C.increase “增加”..74.选D..本题考动词短语..选择动词短语的依据来自对语篇连贯线索的确切理解..下文提到C1inton持有different ideas;即他与国会的意见有分歧;因此答案为D.agree with同意某人的意见、想法..干扰项用法解析:A.agree upon和B.agree on表示“在某件事上取得一致意见”;C.agree to后接动词不定式..用法举例:I don’t agree with you on this point.我不同意你的这个观点..He finally agreed to participate in the experiment.他最终同意了参加实验..至此;全部答案已做完..考生应再重新通读全文;以挑剔的眼光审视所做答案;看它们是否达到了在结构和内容上圆满还原短文的目的..75.选B..本题考宾语从句..前一句提到Clinton总统观点时用了部分否定的句式;即Clinton 总统不完全同意国会关于精简政府和削减开支的意见..换言之;Clinton的总体意见是同意精简政府和削减开支;但在具体细节上与国会有分歧..从下文中可以看到;他们之间的分歧在于“精简哪些部门parts of government”以及“精简的幅度by how much”..因此;先排除C.whose;因为whose parts of government的提法不合逻辑;然后排除不符合“总体上赞成国会意见”的选项;即A.why和D.that;最后确认B.what为正确答案..what parts of government意为“政府的哪些部门”..本句大意:对于国会的计划Clinton总统并非全部赞同;他在政府的哪些部门应该被精简以及开支应削减多少这些问题上持不同观点..Part I TranslationPaper TwoSection A题目精解注意此段短文翻译中被动语态的翻译;并注意句子之间的连贯性..1.本句翻译时;要注意条件状语从句中“If an occupation census had been taken…it would…”的翻译;此句为非真实条件句;表达虚拟语气;应译为“如果……的话;也许会……”;同时要注意定语从句“who drew…”的翻译;应翻译为独立的句子..由于英汉两种语言结构类似;应采用对等翻译法直接翻译..2.本句翻译时;虽然没有条件状语引导词if;但此句所表达的意思相当于非真实条件状语;因此;“…would have revealed...”表达虚拟语气;应译为“如果……的话;就会……”;同时要注意过去分词“taken...”;“unpaved...”和“separated...”的翻译;应视为过去分词做定语..由于英汉两种语言结构类似;应采用对等翻译法直接翻译..3.本句翻译时;虽然没有条件状语引导词if;但此句所表达的意思相当于非真实条件状语;因此;“would show…”表达虚拟语气;应译为“如果……的话;就会……”;同时要注意过去分词“taken…”的翻译;应视为过去分词做定语..由于英汉两种语言结构类似;应采用对等翻译法直接翻译..4.本句翻译时;虽然没有条件状语引导词if;但此句所表达的意思相当于非真实条件状语;因此;“would be…”表达虚拟语气;应译为“应该会有……”;同时要注意现在分词“carrying…”的翻译;应视为过去分词做定语;但译成汉语时;采用增词法;要译为一个句子..同时;要注意定语从句“which had...”的翻译;应译为一个独立句..由于英汉两种语言结构类似;应采用对等翻译法直接翻译..参考译文:1.如果在11世纪作一项职业调查的话;也许会发现;竞有90%的人住在农村;依靠农耕、放牧、捕鱼或靠采伐谋生..2.当时如果航拍一张照片的话;可以看到未经铺设的道路连接的散落村子;中间隔着一片片的森林或沼泽..3.十四世纪中叶所拍的第二张照片可以看到;村庄越来越多了;而且散开了;因为欧洲人通过开辟新的土地;将边疆扩大了..4.道路上和江海上往来的人多了;他们把粮食或原料运往城镇..城镇的数目多了;规模大了;重要性也增加了..5.其次;这一广阔地区的居民无法用我们的标准模式去进行划分;他们也不是一成不变.. Section B题目精解注意此段短文翻译中修辞手法的翻译;并注意句子之问的连贯性..此短文中;句子“这让我觉得很新鲜”译成英语时;要注意汉语的后重心和英语的前重心特点;翻译时要采用句型转换法来翻译;故译为“I find it refreshing that…”..参考译文:As a jazz lover; I find it refreshing that many Chinese pop stars are beginning to be influenced by jazz; and are including jazzy rhythms and harmonies in their songs. However; incorporating jazz elements into pop music does not make it jazz; any more than putting chili pepper into a MacDonald's hamburger turns it into Sichuan cuisine.Part II参考作文Can We Profit More from Computer and InternetComputer and Internet are said to be the biggest wonders ever made by man. They have brought us enormous profits and convenience. But so far still not many Chinese can get access to them. What is the real problemIn my opinion; it involves two sides. The first side lies in the computer and Internet workers. Though technically quite advanced in China; the system is far from being popular for ordinary users. For example; in the west; people can do many kinds of professional jobs at home.E-business and online libraries become a common social service. When traveling; people can book flight tickets and hotel rooms online. Yet; most of Chinese users use the system just to send emails or play games. The other side comes from the traditional opinion on the online practice.Many people prefer to read the newspapers to online news. Therefore; I would like to suggest that online technology should be made more popular for general users to increase their materialspiritual wealth more efficiently.。

纳米材料

纳米材料

Journal of Membrane Science296(2007)1–8ReviewNanofibrousfiltering media:Filtration problemsand solutions from tiny materialsR.S.Barhate a,∗,Seeram Ramakrishna a,b,c,∗a Nanoscience and Nanotechnology Initiative,Faculty of Engineering,National University of Singapore,9Engineering Drive1,Singapore117576.Singaporeb Department of Mechanical Engineering,Faculty of Engineering,National University of Singapore,9Engineering Drive1,Singapore117576,Singaporec Dlivision of Bioengineering,Faculty of Engineering,National University of Singapore,9Engineering Drive1,Singapore117576,SingaporeReceived13February2007;accepted10March2007Available online24March2007AbstractNanotechnologists have discovered newfiltering media for effectivefiltrations.The nanofiber basedfiltering media,made up offibers of diameter ranging from100to1000nm,can be conveniently produced by electrospinning technique.This article addresses the current state of art infiltrations by using the nanofibrousfiltering media.Thesefiltering media are being surface modified to improve their spectrum and capture efficiency of filtration.The developmental objectives for improving the nanofiber basedfiltering media are lower energy consumption,longerfilter life,high filtration capacity and easier maintenance;which are elaborated from manufacturing point of view.Some practical constraints like pleating of thin,extremely low weight and delicate membranes are also discussed.Nanofibrousfiltering media could be used forfiltration of blood,water,air, beverages,gases,chemicals,oils,diesel and petrol,etc.©2007Elsevier B.V.All rights reserved.Keywords:Nanotechnology;Nanofilter;Nanofibers;Particulatefilter;Gasfilter;Microfiltration;Ultrafiltration;CoalescencefilterContents1.Introduction (2)1.1.Structural characteristics of nanofibrousfiltering media (2)2.History of production of nanofibrousfilter media (2)3.Noteworthy applications of nanofibrousfiltering media (3)3.1.Penetrating aerosol particulatefiltering media (3)3.2.High efficiency airfiltering media (3)3.3.Antimicrobial airfilter (4)3.4.Highflux ultrafiltration membrane (4)3.5.Coalescencefilter (4)3.6.Catalyticfilter (4)3.7.Affinityfilter for highly selective separations (4)3.8.Ion-exchangefiltering media (4)4.Techniques for preparation of nanofibrousfiltering media (5)4.1.Benefits from nanofibrousfiltering media (5)4.1.1.Pressure drop (5)4.1.2.Filtration efficiency (5)4.1.3.Surface area (6)∗Corresponding authors.Tel.:+6565162142;fax:+6567730339.E-mail addresses:nnibrs@.sg(R.S.Barhate),seeram@.sg(S.Ramakrishna).0376-7388/$–see front matter©2007Elsevier B.V.All rights reserved.doi:10.1016/j.memsci.2007.03.0382R.S.Barhate,S.Ramakrishna/Journal of Membrane Science296(2007)1–85.Developmental objectives while improving the nanofiber basedfiltering media (6)5.1.Specific surface area (6)5.2.Mechanical andfiltration properties (7)5.3.Surface modification and functionalization (7)6.Conclusions (7)Acknowledgements (7)References (7)1.IntroductionManufacturing and processing companies in food,pharma-ceuticals,biotechnology and semiconductor business require centralized air conditioning in production environment,high-purity water,clean gases and effluent/waste air and water treatment.The control over airborn and waterborn contaminants, hazardous biological agents,allergens and pollutants is a key issue in food,pharmaceuticals and biotechnology processes.The particle size of particulate matter is determined by the process that generates the particles.For instance,combustion particles are usually in the10–50nm size range,but when they combine with other particles and agglomerate form larger particulates. The agglomerate particles may be broken down into smaller particles and release into air.It is difficult to break down such particles smaller than0.5␮m[1].The existing high efficiency airfilters effectivelyfilter particles of0.3␮m and above.How-ever,they are not sufficient forfiltration of smaller pathogenic agents like viruses.Air and water are the bulk transportation medium for trans-mission of particulate contaminants.The contaminants during airfiltration are complex mixtures of particles.The most of them are usually smaller than1000␮m in diameter.Chemical and biological aerosols(particulates)are frequently in the range of1–10␮m.The particulate matters may carry some adsorbed gaseous contaminants.The removal of particulate and biolog-ical contaminants is an important step in water purification process.Particulate contaminants if not removed tend to foul reverse osmosis membranes and severely reduce the throughput of thefinal purification step.Thefiltration industry is looking for energy efficient high performancefilters forfiltration of particles smaller than0.3␮m and adsorbed toxic gases.Nanofibrous media have low basis weight,high permeability and small pore size that make them appropriate for a wide range offiltration applications.In addition,nanofiber membrane offers unique properties like high specific surface area(ranging from1 to35m2/g depending on the diameter offibers),good intercon-nectivity of pores and potential to incorporate active chemistry or functionality on nanoscale.Therefore,nanofibrous membranes are extensively being studied for air and liquidfiltration.Scan-ning electron microscopic picture of nanofibrousfiltering media is shown in Fig.1.1.1.Structural characteristics of nanofibrousfilteringmediaa)thickness(&variation with location);b)fiber diameter(&distribution);c)representative pore size(&distribution);d)porosity;e)tortuosity factor(which is an indicator of geometry and inter-connectivity of pores).2.History of production of nanofibrousfilter mediaThefirst patent for production offibers from a solution jet introduced into electricfiled was issued in1902in the USA [2].The practical results in production of nanofibrous material from polymer solutions were also obtained by A.Formhals in Germany and patented in the USA in1934[3].In1936,I.V. Petryanov-Sokolov’s work offinefiber production in electro-staticfields has given the way for development of production of filter materials,these materials are known since then in Russia as FP(filters of Petryanov,which is now called as nanofibrous filter media)[4].The scientific activities related to production of Petryanovfilters was announced as the top secret because of this Petryanov’s research work never reached the Western Commu-nity[4].After Second World war,special emphasis was given to application of Petryanovfilter materials in nuclear energy technologies for protecting the environment from nuclear-active aerosol release[4].The most of research work on production of nanofibers was carried out at Karpov’s Scientific Research Institute of Physics and Chemistry(Moscow).By the end of the 1960s in the USSR there were5enterprises,producing materi-als of FP type and their modifications with the annual capacity of20million m2(600tonnes)[5].In1964in Sillamyae(Esto-nia)chemical plant was constructed with the largest facility for production of the nanofibrousfilter materials[5].Advances in electrospinning method allowed organization of theindustrial Fig.1.Scanning electron microscopic picture of nanofibrousfiltering media.R.S.Barhate,S.Ramakrishna/Journal of Membrane Science296(2007)1–83 Table1Enterprises in nanofiberfilter media businessS.N.Enterprises Country Address(accessed on15-03-2007) 1Donaldson Company A 2Espin Technologies A 3KX Industries USA 4Ahlstrom Corporation Finland 5Hollingsworth A 6US Global Nanospace USA 7Finetex Technology S.Korea www.fi8Helsa-automotive Germany 9Nanotechnics Co.Ltd.S.Korea 10Teijin Fibers Ltd.Japan www.teijinfi11Toray Japan 12Japan Vilene Company Ltd.Japan www.vilene.co.jp13Nanoval GmbH&Co.KG Germany www.nanoval.de14Hills A 15Nonwoven Technologies A asfabb@16Emergency Filtration products,A www.emergencyfi17Elmarco Czech Republic www.elmarco.cz18Hohns Manville Sales GmbH Germany 19Nanofiber Future Technologies Corp Canada 20Esfil Tehno Republic of Estonia www.esfiltehno.eeproduction of more than twenty types offiberfilter materials [6].In America,the production of nanofibrous materials gained momentum in1980with the efforts of“Donaldson”.In Europe, the commercial production offibers by electroforming method started in1990s by“Freudenberg”[5].A cursory search on internet has revealed that more than twenty enterprises are keep-ing interest in either production or use of nanofiberfilter media (Table1).A few prototype applications of nanofibrousfiltering materi-als are summarized in Table2.Table2Specialtyfiltration applications of nanofibrous mediaS.no.Filtering media Reference 1Airfiltering media for engine airfiltration,cabin airfiltration and self cleaning air intake for gas turbines[7]2Filter media for pulse clean cartridges in dustcollection[8]3Penetrating aerosol particulatefiltering media[9]4High efficiency airfiltering media[10]5Cigarettefilter forfiltration of smoke[11]6Adsorptive catalytic gasfilter for respirators[12]7Layer composite material for protective apparels[13]8Filtering media for catalytic cracking and hightemperaturefiltration[14]9Particulatefiltering media for liquidfiltration[15]10Highflux ultrafiltration media[16]11Water-in-oil emulsion separation media orcoalescence promotingfiltering media[17]12Filter media for hemodialysis[18]13Filter media for wound dressing[19]14Antimicrobial and antimycotic biocompatiblefilterfor wound healing application[20]15Biocatalyticfiltering media[21,22] 16Affinityfiltering media for highly selective separationand diagnostics[23]17Ion-exchangefiltering media[24]3.Noteworthy applications of nanofibrousfilteringmedia3.1.Penetrating aerosol particulatefiltering mediaTheoretical predictions and preliminary investigations indi-cate that significant increase of thefilter efficiency for the most penetrating particle size(between0.1and0.5␮m)accompanied by only a slight rise of the pressure drop,can be achieved by using the nanofibrousfiltering media[7].Recent research work of Podg´o rski et al.[9]also shows thatfibrousfilters containing nanofibers are very promising and economic tools to enhance filtration of the most penetrating aerosol particles.Nanofi-brousfiltering media can be used where high-performance air purification is needed such as in hospitals,healthcare facilities,research labs,electronic component manufacturers, military and government agencies,food,pharmaceutical and biotechnology companies.Podg´o rski et al.[9]recommended triple layer design offibrousfilters dedicated to remove the nanoparticles along with other polydispersed aerosol parti-cles(the back support layer of densely packed microfibers, the middle nanofibrous layer for collection of most penetrat-ing aerosol particles and front porous layer offibers of a few micrometers diameter for collection of micrometer sized particles).3.2.High efficiency airfiltering mediaHigh efficiency particulate air(HEPA)filters have minimum removal efficiency of99.97%of particles greater than or equal to 0.3␮m in diameter.Thefiltration efficiency of Nylon6nanofil-ter(made by thefibers of diameter80–200nm and having basis weight10.75g/m2)is measured using0.3␮m challenge parti-cles at the face velocity between3and10cm/s and found to be superior to the commercialized HEPAfilter[10].4R.S.Barhate,S.Ramakrishna/Journal of Membrane Science296(2007)1–83.3.Antimicrobial airfilterHeating,ventilating and air conditioning(HV AC)airfilters indented for air purification operating in dark,damp and ambi-ent temperature conditions are more susceptible for bacterial, mold and fungal attacks.The situation become worse when these microorganisms adhere to the accumulated dust on thefil-ter and consume the accumulated dust as food and proliferate As a result there is unpredictable deterioration of quality of air and production of bad odor.The most common attacking microor-ganisms on HV ACfilters are from Staphylococcus,Serratia, Klebsiella,Cladosporium and Aspergillus species.Recently, there is an attempt to functionalize the surface offiltering media with antimicrobial agents for long lasting durable antimicro-bial functionality[25].Recently,one more relevant article on preparation of antimicrobial nanofibrousfilter is published[26]. This concept of introducing antimicrobial functionality over the particulatefilters is needed to explore in more systematic fash-ion because the most of these microorganisms often become resistant and limit the benefits of antimicrobial functionality. Furthermore,the most of the microorganisms enter to thefil-ter with airborne particulate and they grow in size on their accumulation and build up on thefilter surface.This consider-ably reduces the contact of microorganisms with antimicrobial agent/s present on surface offilter and further limits the intended benefits.Metallic silver and silver oxides are safe and effective antimicrobial agents at low level[27].Positively charged silver ions attract to electronegative bacterial cells and bind with the sulfhydryl group of cell membrane or bacterial DNA and result in the prevention of proliferation of microorganisms[28].Ionic plasma processing(IPD)is a suitable method for coating sur-face engineered nanosized silver particles on polymeric surfaces [27].The IPD technology is adoptable because it can be used at ambient temperature.3.4.Highflux ultrafiltration membranePorous polymeric ultrafiltration membrane manufactured by the conventional method(phase immersion method)has its intrinsic limitations,e.g.lowflux and high fouling tendency due to geometric structure of pores and the corresponding pore size distribution[29]and undesirable macro-void formation across the whole membrane thickness[30].Recently,Yoon et al.[16]have shown that porous electrospun nanofibrous scaffolds (porosity larger than70%)can be used to replaceflux limit-ing asymmetric porous ultrafiltration membranes(of porosity in the range of34%).Yoon et al.[16]have recommended the three-tier approach to fabricate highflux and low fouling ultrafil-tration membranes.In their study,polyacrylonitrile nanofibrous layer was supported on the nonwoven microfibrous substrate (melt blown polyethylene terephthalate mat)and water resistant but water permeable coating of chitosan was applied over the nanofibrous layer.3.5.CoalescencefilterIn recent years,water in oil emulsion separation has received greater attention.In many applications,dispersions of water drop sizes of less than100␮m are very difficult to separate. The coalescencefilter is economical and effective for separation of secondary dispersions[31].Coalescencefilter performance depends onflow rate of feed,drop sizes in the feed,filter bed depth and surface properties offilter material/s.Fibrousfilter media provide the advantage of highfiltration efficiency at eco-nomical energy costs.Fibrousfilter media with large contact areas per unit mass is expected to perform better in promoting coalescence than the media with lesser surface areas.Addition of polystyrene nanofibers to the coalescencefilters(glassfibers) modified the performance of coalescencefilters;thefiltration experiments have shown that the addition of small amounts of polystyrene nanofibers significantly improve the coalescence efficiency of thefilter but also significantly increase the pres-sure drop of thefilters[17].There exist an optimum amount of nanofibers to be added to the coalescencefilter media[32],which balances the desired improvement in coalescence efficiency and the undesirable increase in the pressure drop.3.6.CatalyticfilterDevelopment of both stable and active enzyme systems is still a challenging issue in realizing the successful application of enzymes for industrial applications.Highly specific catalysts like enzymes can be recycled and reused by stabilizing and coat-ing over surface area of polymer nanofibers.The specific surface area of nanofibrous membrane can be enhanced by reducing the diameter offibers.Gibson et al.[33]studies show that the elec-trospinning process can be conventionally used to produce a specific surface area ranging from1to35m2/g;depending on the diameter offibers.Fibrous membrane made of porousfibers further enhances the specific surface area of membrane.The spe-cific surface area result from the porousfibers is much higher than that is possible by reducing the diameter offibers.The nanofibrous media has an advantage over mesoporous media by relieving the mass transfer limitation of substrates/product due to their reduced thickness and intrafiber porosity.Jian et al.[34] demonstrated that the covalent attachment of enzymes to the polystyrene nanofibers.3.7.Affinityfilter for highly selective separationsAffinity membranes for highly selective separations are prepared in our laboratory by the surface modification and func-tionalization of nanofibers[23,35,36].These membranes are expected to improve performance in preparative scale protein purifications.3.8.Ion-exchangefiltering mediaConventional ion exchange resins are normally either a gel structure or a granular structure and are typically made of styrene or acrylic as the structural materials.Granular resinous materi-als have large pore volume and low ion-exchange capacity than gel type materials.However,the granular materials have better mechanical strength over gel type materials.More recently,the fibrous materials are recognized as a support for ion-exchangeR.S.Barhate,S.Ramakrishna/Journal of Membrane Science296(2007)1–85functionality due to ease of preparation,contact efficiency,phys-ical requirements of strength and dimensional stability[37]. Polymeric nanofiber based ion exchanger has high swelling behavior compared to other media because of high surface area,porosity and capillary motion[24].In addition,Polymer nanofiber ion exchanger is found to possess extremely rapid kinetics and higher ion-exchange capacity[24].4.Techniques for preparation of nanofibrousfiltering mediaThe challenges realized during fabrication of nanofiber mat are(1)attaining the homogeneity in size(diameter)distribution offibers in the mat,(2)attaining the uniformity in deposition and orientation offibers in the mat(thickness and structural indexes) and(3)obtaining durability offiber layers in the nanofiber mat [38].There are three major processes for producing nanofibres forfluidfiltration media.They include electrostatic spinning (electrospinning),improved modular melt blowing and multi-componentfibre spinning or the‘islands-in-the sea’method [39].Each process has its advantages and disadvantages.The most versatile process for producing nanofibers is the electro-spinning[40–43],which is being used to produce nanofibrous membranes over the wide range of porosity ranging from nonporous polymer coatings to macroporous delicatefibrous structures.Electrospinning requires the massive scale solvent recovery from the dilute air stream,which makes the process uneconomic.While the polymer dissolution prior to spinning (up to10–20%,w/w,solution of polymer)and low opera-tional feed rates(polymerflow of about0.01–0.30g per orifice per minute)limit the throughput from the process.Further-more,important polymers such as polypropylene,polyethylene terephthalate,PTFE(Teflon)are not dissolvable in acceptable organic solvents at room temperature.The polymerflow rate of0.8–1.2g per orifice per minute is generally considered to be an economically viable for commercial scale operation[39]. For a viable nanofiber production process,electrospinning sta-tion must have10–20times the number of orifices per metre of the standard equipment available in the market.Electro-spunfibers have diameter smaller than that of the melt blown fibers.Currently,there are investigations aimed at improving of the melt blowing technique to produce nanofibers.The melt-blown technique allows making large quantities offibers at low cost.Numerous innovations of the extrusion die appara-tus are described in the prior art of patent namely“Disposable extrusion apparatus with pressure balancing modular die units for the production of nonwoven webs”[44].Ability to pro-duce large quantities of nanofibrousfiltering media with precise controlled porosity(interfiber and intrafiber)is still unresolved issue.4.1.Benefits from nanofibrousfiltering mediaThe dependence offilter characteristics such as pressure drop,filter efficiency and surface area on the geometric structure of fibrousfilter media is of great practical significance.4.1.1.Pressure dropFor nanometer-scalefibers,the effect of slipflow at thefiber surface has to be taken into account.This is because the scale of thefiber becomes small enough that the molecular movements of the air molecules are significant in relation to the size of the fibers andflowfield.Knudsen number is used to describe the importance of the molecular movements of air molecules at the fiber surface to the overallflowfield.The Knudsen number can be written asKn=λR fwhere“λ”is the gas mean free path(the dimension of the non-continuous nature of the molecules),and R f is the mean radius of thefibers.When Kn becomes non-legible,the continuousflow theory(which does not take into account the molecular nature of air)starts to become less valid.There is no exact Kn above which slipflow will prevail.Slipflow generally needs to be considered when Kn>0.1.Slipflow definitely needs to be considered when Kn is around0.25.For air at standard conditions,the mean free path is0.066␮m;therefore,forfibers with diameters smaller than0.5␮m,slipflow must be considered.In slipflow,the air velocity at thefiber surface is assumed to be non-zero.Due to the slip at thefiber surface,drag force on afiber is smaller than that in the case of non-slipflow,which translates into lower pressure drop[45].4.1.2.Filtration efficiency4.1.2.1.Airfiltration.In case of airfiltration,pores size is nota complete indicator of efficiency offiltration.Airfilters have traditionally been evaluated based on their ability to remove particulate matter from the air stream.Particulatefilters sepa-rate the particles from air stream by the virtue of size,shape and charge of particles in relation to surface,size and charge prop-erties offibrousfilter.Differentfiltration media rely on different physical interaction mechanisms for separation and collection of particles.Eachfiltration medium and its associated interac-tion mechanisms result into different efficiencies for particles of different sizes.The most common interaction mechanisms are direct interception,inertial impaction,Brownian diffusion and gravity settling.The total efficiency offilter(E)is resulted by collective contribution of individual efficiencies from the above interaction mechanisms.The larger particles more than 10␮m deviates from air stream before reaching to thefilter because of gravitational settling.The following particle ranges can be approximately assigned to these interaction mechanisms (Fig.2).Very small nanoparticles are effectivelyfiltered even in con-ventional microfibrousfilters due to very efficient mechanism of Brownian diffusion[9].The larger particles(greaterthanFig.2.Operative particle size in various interaction mechanisms.6R.S.Barhate,S.Ramakrishna /Journal of Membrane Science 296(2007)1–8Table 3Structural parameters of filters a S.N.Filter number Thickness (mm)Fiber diameter (␮m)Solidity (dimensionless)Basis weight (g/m 2)Filter specific area (m 2/m 3)113100.12730.4×10522120.0545.5 1.0×1053310.70.0218.2 1.14×105440.20.10.0050.912.0×105aReprinted from [9]with permission fromElsevier.Fig.3.Calculated fractional efficiency for filters as a function of aerosol particle diameter (␩1,␩2,␩3and ␩4represents fractional efficiency of filter 1,2,3and 4,respectively)(reprinted from [9]with permission from Elsevier).0.3␮m)are filtered by the impaction and interception.The maxi-mum penetrating particles from air filter are about 0.3␮m in size (which justify why HEPA filter testing is often recommended by using challenge particles of diameter of 0.3␮m).This result was anticipated in 1942by Dr.Irving Langmuir,which led to the development of HEPA filters.Podg´o rski et al.[9]estimated performance of nanofibrous media for filtration of particles of diameter of 10–500nm;sim-ulated filtration performance considering two predominating mechanisms namely Brownain diffusion and the direct inter-ception for the filters defined in Table 3is shown in Fig.3.Fig.3illustrates the effect of decreasing the fiber size in a filter media on filtration performance at the most penetrating particle size range (i.e.the particle diameter corresponding to the lowest fractional efficiency point in the curve)and enhancing fractional efficiency.4.1.2.2.Liquid fiing polystyrene particles of size 0.1–10␮m,particulate filtration performance of nanofibrous filtering media from the liquid medium was evaluated in our laboratory [46].It was observed that an electrospun membrane conveniently rejects the microparticles and acts as a screen filter without fouling the membrane especially when the particles are larger than the largest pore size of the nanofibrous membrane.High surface to volume ratio of nanofibrous media enhances the fouling.Therefore,surface modification of nanofibrous screen filter with suitable hydrophilic or hydrophobic oligomer is often recommended to reduce the fouling effect.In order to reduce the fouling effect,a work is in progress in our laboratory.4.1.3.Surface areaGibson et al.[33]estimated the specific surface area of nylon 6,6fibers as a function of diameter and denier of fibers.The membranes prepared by the approach of reducing the diame-ter of fibers had extremely small pore throat diameters (ranging from 0.1to 0.8␮m in size)[33],which leads to high air flow resistance.These nanofibrous coatings are suitable for filtra-tion and moisture management in the application like responsive textile and protective clothing.For an integrated operation like adsorptive filtration,the membranes must have enhanced surface and flow properties.Filtering media made of porous nanofibers and microfibers would be promising for adsorptive filtration applications.5.Developmental objectives while improving the nanofiber based filtering media 5.1.Specific surface areaThe specific surface area of fibrous materials can be consid-erably enhanced by introducing the micropores (less than 2nm)and mesopores (2–50nm)in the fibers.Phase separation dur-ing the fiber formation process can be conveniently used to introduce the fine pores or phase morphologies in the fibers [47,48].Phase separation accomplished from the two compo-nents system (polymer/solvent system)provides a single stage process to create the fine pores in the fibers.The phase separation accomplished from the three components system (polymer-1/polymer-2/solvent system)requires an additional extraction step to selectively remove the finely dispersed phase morpholo-gies of polymers from the dried fibers and to create pores in the fibers.Recently,McCann et al.[49]reported a method for cre-ation of pores in the fibers wherein the partially dried jet (wet fiber)produced from the two-component system is frozen by passing through a bath of liquid nitrogen before collecting on the target.Due to sudden reduction in temperature during the freez-ing step,phase separation sets in the partially dried jet resulting into formation of a solvent-rich phase (dispersed phase)and a polymer-rich phase (continuous phase).The dispersed solvent-Table 4Interfiber bonding conditions for a few polymeric nanofibers S.N.Nanofibrous webTreatment Ref.1Poly(etherimide)nanofibers web 240◦C for 1h [50]2Cellulose acetate nanofibers web 208◦C for 1h [35]3Polysulfone nanofibers web188◦C for 6h [36]4Polyvinylidine difluoride nanofibers web145◦C for 18h[15]。

非极大值一致 nms的工作流程英语

非极大值一致 nms的工作流程英语

非极大值一致 nms的工作流程英语Non-Maximum Suppression (NMS)。

Non-maximum suppression (NMS) is a technique used in object detection to remove redundant bounding boxes that overlap with each other. It aims to retain only the most confident bounding boxes that are likely to contain the object of interest.Workflow of Non-Maximum Suppression.The workflow of NMS involves the following steps:1. Input: NMS takes as input a set of bounding boxes and their corresponding confidence scores.2. Sort Confidence Scores: The bounding boxes are sorted in descending order of their confidence scores.3. Iterate Over Bounding Boxes: The algorithm iteratesover the bounding boxes in descending order of their confidence scores.4. Select Best Bounding Box: The bounding box with the highest confidence score is selected as the best bounding box.5. Calculate Overlap: For each subsequent bounding box in the iteration, the algorithm calculates the overlap between it and the best bounding box.6. Suppress Overlapping Boxes: If the overlap between a subsequent bounding box and the best bounding box exceeds a predefined threshold, the subsequent bounding box is suppressed and removed from the list of bounding boxes.7. Repeat Until No Overlap: Steps 5 and 6 are repeated until there are no more overlapping bounding boxes.8. Output: The output of NMS is a set of non-overlapping bounding boxes that represent the most confident object detections.Threshold Selection.The threshold used for overlap calculation is crucialfor the effectiveness of NMS. A low threshold can result in excessive suppression, while a high threshold may lead to missed detections. The optimal threshold value depends on the specific object detection task and the size of the bounding boxes.Variations of Non-Maximum Suppression.There are several variations of the basic NMS algorithm, including:Soft NMS: This variation allows for partialsuppression of overlapping bounding boxes, preserving bounding boxes with lower confidence scores but higher overlap.Adaptive NMS: This variation adjusts the suppression threshold based on the size of the bounding boxes toaccommodate scale variations.Weighted NMS: This variation assigns weights to the bounding boxes based on their confidence scores and spatial locations to prioritize suppression of less important bounding boxes.Applications of Non-Maximum Suppression.NMS is widely used in object detection and computer vision applications, such as:Object localization.Image classification.Facial detection.Pedestrian detection.Vehicle detection.Scene understanding.Additional Notes:NMS is a greedy algorithm, meaning it makes locally optimal decisions at each step without considering thelong-term impact on the result.NMS can be computationally expensive for large sets of bounding boxes.Alternative approaches to NMS for removing redundant bounding boxes include grouping and clustering techniques.。

生物信息学复习题及答案(陶士珩)

生物信息学复习题及答案(陶士珩)

生物信息学复习题名词解释1. Homology (同源):来源于共同祖先的序列相似的序列及同源序列。

序列相似序列并不一定是同源序列。

2.Orthologs(直系同源):指由于物种形成的特殊事件来自一个共同祖先的不同物种中的同源序列,它们具有相似的功能。

3.Paralogs(旁系(并系)同源):指同一个物种中具有共同祖先,通过基因复制产生的一组基因,这些基因在功能上的可能发生了改变。

基因复制事件是促进新基因进化的重要推动力。

4.Xenologs (异同源):通过横向转移,来源于共生或病毒侵染而产生的相似的序列,为异同源。

5.Identity Score:The sum of the number of identical matches and conservative (high scoring) substitutions in a sequence alignment divided by the total number of aligned sequence characters. Gap总是不计入总数中。

6.点矩阵(dot matrix):构建一个二维矩阵,其X轴是一条序列,Y轴是另一个序列,然后在2个序列相同碱基的对应位置(x,y)加点,如果两条序列完全相同则会形成一条主对角线,如果两条序列相似则会出现一条或者几条直线;如果完全没有相似性则不能连成直线。

7. E值:得分大于等于某个分值S的不同的比对的数目在随机的数据库搜索中发生的可能性。

衡量序列之间相似性是否显著的期望值。

E值大小说明了可以找到与查询序列(query)相匹配的随机或无关序列的概率,E值越小意味着序列的相似性偶然发生的机会越小,也即相似性越能反映真实的生物学意义,E值越接近零,越不可能找到其他匹配序列。

8.P值:得分为所要求的分值比对或更好的比对随机发生的概率。

它是将观测得到的比对得分S,与同样长度和组成的随机序列作为查询序列进行数据库搜索进行比较得到的HSP(高分片段对)得分的期望分布联系起来计算的。

RoboCup-99 Team Descriptions Simulation League, Team Zeng99, pages 0–0

RoboCup-99 Team Descriptions Simulation League, Team Zeng99, pages 0–0

1 outline of HiFIC system is shown.Section explains middle and lower layer configuration those are main part of HiFIC system.2Hierarchical Fuzzy Intelligent Control Sys-tem1[Fig.1]shows a configuration of the system.That system is designed for unstable and/or nonlinear systems.Soccer agents have non-holonomic restriction. Thus the control needs complicated sequence of(turn)and(dash)com-mand.In another hand,human beings could control such an ill-system and could learn how to control it.HiFIC is based on this type of human beings’control strategy,those main point is a macroscopic recognition.Every part of layer accept same sensory inputs.It reconstructs them on demand of decision making.Each layer accepts a macroscopic tactical commands from upper layer.An input from upper layer is in a form of macro command, and that cann’t be executed immediately at layer receiveing it.That macro command has some fuzziness of that meanings,consequently interpretation process is needed to execute it.These interpretation chain among layers are remarkable characteristics.To realize a cooperative behavior within the highest layer,three technical problem should be there;macroscopic recog-nition of game situation,simulation based prediction of game and decision making in fuzziness.Middle layer and lower layer,which are a main part of control,is explained in detail at next subsection3Middle layer and lower layerMiddle and lower layer makes sure primary movements.Lower controller interprets a behavior commands into executable command sequence.ßMiddle layer:behavior control Middle layer controls a behavior of tactical moves by means of fuzzy logic rules.Tactical moves consist of a server command sequence.This sequence is a tactical behavior(2[Fig.2]).This knowledge as tactical rules R CURL(sj)configured from three kind of arts.R sji :if CONDIT ION is C i thendo M i,i=1...n where CONDITION is avector of control and game situation at that time.Current index of the rule used at that time is included in the situation CONDITION vector,therefore they could apply rules sequentially according to the rule indexes.3[Fig.2 ]shows the state transition through rules.M1Ref:http://./figs/fig1.html2Ref:http://./figs/fig2.html3Ref:http://./figs/fig2.html2properties of player agents in soccer server.If there were no errors insensory inputs and server command results,any middle level commandcould be transformed into just one turn and one dash.However,errorsexist in sensor and command execution.Error occurs after command ex-ecution.To avoid that error,the system needs feedback loop.A mid-dle layer macro command“go to point X”should be realize as an feed-back algorithm.“Go To Point X”1.Turn to heading for the point(turn$a*t)2.Dashtocomeclosedestination(dash$p(d))3.until gettingdestination X,go to1.and repeat.Function p(d)calculates power to gothrough d distance.“a”in the turn command is a feedback ratio The lib-sclient embedded Tcl/Tk shell,we call it sc w ish,isformakingprototypeswithGUIfacility.T he sc w ith isd nameport−num sc s end“(servercommand) setmsg[receive m essage]sc c onnect withservernameandport 5SummaryHierarchical Fuzzy Intelligent Control system is adopted to socceragents.Zeng99team becomes a test bench for developing how todesign cooperative behavior on the HiFIC system.It enable us tomake a control rules from human knowledge since it accept linguisticmacroscopic command notation.The sc w ishthatembedlibsclientlibrarymakesiteasytoconstructpr 6BibliographyJunji NISHINO,Akihiro TAGAWA,Haruhiko SHIRAI,Tomohiro ODAKA,and Hisakazu OGURA.Hierarchical fuzzy intelligent controller forgymnastic bar actions.Journal of Advanced Computational Intelligence,1999.to be appeard.Jens Rasmussen.Skills,rules,and knowledge;signals,signs,and symbols,and other distinctions in human performancemodels.IEEE Trans.SMC,13(3):257--266,1983.。

(2024年高考真题含解析)2024年普通高等学校招生全国统一考试英语试卷 新课标Ⅰ卷(含解析)

(2024年高考真题含解析)2024年普通高等学校招生全国统一考试英语试卷 新课标Ⅰ卷(含解析)

2024年普通高等学校招生全国统一考试新课标Ⅰ卷英语试卷姓名________________ 准考证号________________全卷共12页,满分150分,考试时间120分钟。

养成良好的答题习惯,是决定成败的决定性因素之一。

做题前,要认真阅读题目要求、题干和选项,并对答案内容作出合理预测;答题时,切忌跟着感觉走,最好按照题目序号来做,不会的或存在疑问的,要做好标记,要善于发现,找到题目的题眼所在,规范答题,书写工整;答题完毕时,要认真检查,查漏补缺,纠正错误。

考生注意:1. 答题前,请务必将自己的姓名、准考证号用黑色字迹的签字笔或钢笔分别填写在试题卷和答题纸规定的位置上。

2. 答题时,请按照答题纸上“注意事项”的要求,在答题纸相应的位置上规范作答,在本试题卷上的作答一律无效。

第一部分听力(共两节,满分30分)做题时,先将答案标在试卷上。

录音内容结束后,你将有两分钟的时间将试卷上的答案转涂到答题纸上。

第一节(共5小题;每小题1.5分,满分7.5分)听下面5段对话。

每段对话后有一个小题,从题中所给的A、B、C三个选项中选出最佳选项。

听完每段对话后,你都有10秒钟的时间来回答有关小题和阅读下一小题。

每段对话仅读一遍。

例:How much is the shirt?A. £19.15.B. £9.18.C. £9.15.答案是C。

1.What is Kate doing?A.Boarding a flight. B.Arranging a trip. C.Seeing a friend off.2.What are the speakers talking about?A.A pop star. B.An old song. C.A radio program.3.What will the speakers do today?A.Go to an art show. B.Meet the man's aunt. C.Eat out with Mark.4.What does the man want to do?A.Cancel an order. B.Ask for a receipt. C.Reschedule a delivery.5.When will the next train to Bedford leave?A.At 9:45. B.At 10:15. C.At 11:00.第二节(共15小题;每小题1.5分,满分22.5分)听下面5段对话或独白。

非编码RNA来源的小肽:“微不足道”却“功能强大”

非编码RNA来源的小肽:“微不足道”却“功能强大”

第 62 卷第 3 期2023 年 5 月Vol.62 No.3May 2023中山大学学报(自然科学版)(中英文)ACTA SCIENTIARUM NATURALIUM UNIVERSITATIS SUNYATSENI非编码RNA来源的小肽:“微不足道”却“功能强大”*陈晓彤,赵文龙,孙林玉,王文涛,陈月琴中山大学生命科学学院,广东广州 510275摘要:非编码RNA(ncRNA, non-coding RNA)长久以来被认为不具有编码能力。

近年来随着研究技术和生物信息学工具的迅速发展,研究发现在基因组的非编码区域上存在大量小开放阅读框(sORFs,small/short open read‐ing frames),其翻译产物被称作小ORF编码肽(SEPs,sORF encoded peptides)或小肽(micropeptides)。

部分小肽被证实在细胞内稳定存在并独立于其来源RNA发挥重要作用。

本文系统总结了非编码RNA来源小肽的鉴定方法、可编码小肽的RNA类型以及其研究困难和瓶颈,并重点回顾了疾病和植物中发现的功能小肽,以期对小肽的筛选鉴定提供思考,对小肽作为药物研发或者农作物增产的关键靶点提供新的思路和方向。

关键词:非编码RNA;小肽;非经典翻译;鉴定方法;调控机制中图分类号:Q71 文献标志码:A 文章编号:2097 - 0137(2023)03 - 0001 - 13 Micropeptides derived from non-coding RNAs: Tiny but powerful CHEN Xiaotong, ZHAO Wenlong, SUN Linyu, WANG Wentao, CHEN Yueqin School of Life Sciences, Sun Yat-sen University, Guangzhou 510275,ChinaAbstract:It was long presumed that non-coding RNAs (ncRNAs) are lacking in protein-coding poten‐tial. However, recent advances in technology and tools have led to an important finding that a number of small open reading frames (sORFs) were found in different kind of ncRNAs, and their translated products have been termed sORF encoded peptides (SEPs) or micropeptides. Some micropeptides have been confirmed to exist stably in cells and play important roles independently of their source RNA. In this review,we summarize the identification methods of micropeptides derived from ncRNAs,the types of RNA that can encode micropeptides,and focus on the functional micropeptides found in diseases and plants. The purpose of the review is to provide a thought on the screening and identifica‐tion of micropeptides, and provide new ideas for micropeptides as potentials for drug development or crop yield improvement.Key words: non-coding RNA; micropeptide; non-canonical translation; identification methods; regula‐tion mechanism随着人类基因组计划的完成以及ENCODE计划的开展,科学家发现,约75%的基因组可以产生转录本(Derrien et al.,2012;Djebali et al.,2012)。

Lagrange

Lagrange

Rigid Body DynamicsProfessor Sanjay SarmaNovember 16, 20071.0 Where are we in the course?Thus far we have completed Kinematics and Kinetics of single particles, systems of parti­cles and rigid bodies respectively. We are now well into the Lagrange portion of the class.SystemParticleSystem of particles Rigid Bodies Lagrangian formulation Oscillations Kinematics Kinetics & ConstitutiveNext2.0 Generalized CoordinatesThe generalized coordinates of a mechanical system are the minimal group of parameters which can completely and unambiguously define the configuration of that system. Some generalized coordinates are more “natural” than others, but there might be many ways to define them for any one system. The number of generalized coordinates equals the number of degrees of freedom of the system as long as the system is holonomic. We only study holonomic systems in this class.Consider a system consisting of N rigid bodies in 2D space. Each rigid body has 3 degrees of freedom: two translational and one rotational. The N-body system has 3n degrees of freedom. Now let’s say that there are k kinematic constraints which can be expressed as algebraic equations. Then the system has d =3N k degrees of freedom.–The term “holonomic” refers to the fact that the kinematic constraints must be expressible as algebraic equalities. Some kinematic constraints can only be expressed as inequalities or differential equations. Such systems are called non-holonomic constraints. We will not consider non-holonomic systems in this class— if you are interested in such systems, you can talk to me about them outside class.3.0 Why Lagrange?There are several reasons why the Lagrange Approach is important.1. The Lagrange Approach automatically yields as many equations as there are degrees offreedom. It has the convenience of energy methods, but whereas energy conservationonly yields just one equation, which isn’t enough for a multi-degree-of-freedom sys­tem, Lagrange yields as many equations as you need.2. The Lagrange equations naturally use the generalized coordinates of the system. Bycontrast, Newton’s Equations are essentially Cartesian. You end up having to converteverything into Cartesian components of acceleration and Cartesian components offorces to use Newton’s Equation. Lagrange bypasses that conversion.3. The Lagrange approach naturally eliminates non-contributing forces. You could do thesame with the direct (Newtonian) approach, but your ability to minimize the number ofvariables depends very much on your skill; Lagrange takes care of it for you automati­cally because the generalized forces only include force components in directions ofadmissible motion .4.0 The Lagrange EquationsFor a d -dof (degree-of-freedom) system with generalized coordinates q j ’s, it is possibleto formulate the Lagrangian L = T – V where T is the kinetic energy and V is the poten­tial energy . The Lagrangian is a function of generalized coordinates q j ’s and generalized· velocities q j ’s:·· L q 1,, q 1,…q · ) .1 (EQ 1)L = (…q j …q d …q j d where d is the number of degrees of freedom.The Lagrange Equations are then:d d t ⎛⎝∂∂ L q · j ⎞⎠ – ∂∂L q j = Q j , (EQ 2)where Q j ’s are the external generalized forces. Since j goes from 1 to d , Lagrange gives usd equations of motion.But what are generalized forces? We derived them in class. Read on.4.1 Generalized ForcesThe generalized force Q j is defined below:1. There are some situations in which the Lagrangian is explicitly a function of time. Such systems arecalled rheonomic systems. We will not explore the implications in this course.q xy δqΔyΔxFIGURE 1. A bead on a wireQ j = F i i = 1 N ∑ • ∂q j ∂r i ⎝ ⎠ ⎜ ⎟ ⎛ ⎞ (EQ 3)where F i is the force at point i and r i is the position vector of point i . The index j corre­sponds to generalized coordinates.4.2 The IntuitionSo why does the Lagrange formulation work? The insight is simple. The Lagrange formu­lation only considers admissible motions .4.2.1 The Problem with the Newtonian ApproachConsider a bead sliding without friction on a curved wire as shown in Figure 2. Clearly thebead can only move along the wire, which can be approximated locally as a direction tan­gential to the wire. Now, the Cartesian coordinates of the bead would be x and y . However,these coordinates are redundant. We can only eliminate the redundancy by introducing ageometric constrain between x and y of the form Constraint x y (, ) = 0 .1 For example, ifthe wire is in the form of a circle of radius R , the constraint will be x 2+ y 2– R 2= 0. Nocombination of Δx and Δy is legal if it does not satisfy x 2+ y 2– R 2= 0.In the direct, or Newtonian approach, we waste a lot of time considering x and y motionsas if the bead could get to any x and y (which it can’t), postulating reaction forces (whichare actually irrelevant) and then solving for these reaction forces and motions such that theΔx and Δy satisfy the kinematic constraint (which is a waste of time). The problem, as 1. We will assume that this is an algebraic. If it is an inequality constraint or an unintegrable differentialequation, we need more machinery which we will not cover in this course.12Let’s say you tryto move in thisdirection.5 A reaction forcekeeps the bead onthe wire.3 This reaction force is irrelevant because it adapts to counter any applied force, and it doesn’t do work.4 So why even consider impossible motions and the forces we need to make them vanish? They don’t impact the dynamics of the system.So if we only consider motions which are in admissible directions and the forces in thesedirections, we can solve the kinetics of the problem. Hello Lagrange!FIGURE 2. Admissible motions and the non-contributing forces that enforce themshown in Figure 2, is that we do everything explicitly and in the process, we end up solv­ing for a number of extra variables like reaction forces and inadmissible motions whichend up being irrelevant to the actual dynamics of the system. Essentially, pushing at animmovable object causes to motion.4.2.2 Admissible MotionsHere’s the rub. The use of a good set of generalized coordinates eliminates this problembecause generalized coordinates implicitly capture admissible motions . For example, ifour wire is in the shape of a circular loop, an appropriate generalized coordinate is theangle of bead on the wire loop as shown in Figure 3 (a). If our wire were a cosine shape, itwould look like Figure 3 (b) (I will concentrate on the circle in these notes, and leave it toyou to work the math out for the sinusoid.) Now, consider the position vector r written as afunction of q for the circular loop:r q = (R cos q )+ (R sin q )a 2.() a 1 qq FIGURE 3. Different wire shapes and relevant generalized coordinatesa) A circular loopb) A sinusoidal wire r r a 1 a 2R A F q ∂ ∂r A (admissibledirection ofmotion)q ∂ ∂r A FA∂rNow consider the expression . (We were sloppy about specifying the frame for the derivative in the past, and we will omit it in the future under the assumption that when not stated, the frame of reference for a derivative is the inertial frame A.) Let’s compute this expression:∂r=– (R sin q)a1+ (R cos q)a2.Guess what, this vector is tangential to the circle and instantaneously captures the admissi­ble motion of the bead. A small variation of q, δq, results in a δr given by:δr = ∂rδq .(EQ4)δr is an admissible motion for the bead. It captures the kinematic constraint. In general, in a d-degree-of-freedom system with generalized coordinates q1,…,q d , the admissible motions at a point i with position vector r i are given by:d δr i = ∑∂r ijδq j .(EQ5)j =1Note that the symbol δ in front of a variable emphasizes that the motion is an implicitly admissible motion. The d-dimensional version is actually a d-dimensional tangent space just like in a 1-dof case.4.2.3 f = m a Written as Components in Admissible DirectionsIf you applied a force F on the bead shown in Figure 1, the only component which is rele­vant, assuming the wire is rigid, is the component of the force along the admissible direc­tion. For the bead, this is given by ∂∂rq. So the only force component we need to worryabout is:∂rF •∂q .(EQ6)All other forces are perpendicular to the motion and don’t do any work! Of course, ∂∂r qisn’t a unit vector, and its dimensions are those of a length, but don’t worry about that for a moment. What we have just derived is the generalized force for a 1-dof system.Newton’s Law says F = m a . We have just accounted for the LHS along the admissibledirection. Similarly, the only acceleration component we need to worry about is the one inan admissible direction, and the RHS of Newton’s Equation of motion can be written as:∂r ··m r• (EQ 7)∂q when we recognize that a = r··. So taking the components of Newton’s Laws in the admissible direction only, we get:F • ∂r = m r ··• ∂r . (EQ 8)or, looking at work, we get:∂r ∂r F •δq = m r ··•δq . (EQ 9)Look familiar? This is how we started our derivation of Lagrange’s Equations. This leadsto the 1-dof Lagrangian Equation. The LHS is Q , the generalized force. Essentially, the RHS of Equation 8 reduces to:d ⎛⎞∂L ∂L Q = ⎝⎠– . (EQ 10)dt · Look up the derivation from class to see why. You can extend this reasoning to multi-dofsystems and get the general Lagrangian Equation:d ∂L ∂L ⎛⎞– = . (EQ 11)·dt ⎝∂q j ⎠∂q j Q j 4.2.4 Generalized Forces AgainSo the key matter regarding generalized forces is this:• Forces of constraint which do not do work can be ignored because they will alwaysbe perpendicular to admissible directions. Examples include the internal forces in arigid body, the forces of reaction in friction-less sliding, and so on.• Forces which derive from a potential function like gravity or a spring can be consid­ered in potential energy, V . They too can be ignored when computing generalizedforces.• Internal forces in rigid bodies do not contribute.• Forces in pure rolling don’t contribute.• Forces which are none of the above need to be called out and used in Formula 3. Wewill call such forces contributing forces. Examples include dissipative forces fromdashpots, externally applied forces and so on. You can’t go wrong including a forcein this category instead of one of those above because they will vanish or beaccounted for appropriately here.5.0 Using Lagrange’s EquationsThe steps in computing the equations of motion using Lagrange’s method are below.Start with the LHS of Equation 11:1. Identify the generalized coordinates. Make sure that you have just as many as thereare degrees-of-freedom.2. Compute the kinetic energy T as a function of q j ‘s and q · j‘s. 3. Compute the potential energy V as a function of q j ‘s and q · j‘s. Clearly mark out the forces which you will call out as potential and forces which you will call out asexternal4. Compute L = T – V , which will obviously be a function of q j ‘s and q · j‘s. 5. Compute d ⎛ ⎞ ∂L and ∂L and you have the LHS for each j .dt ⎝· j ⎠jNow the RHS of Equation 11:1. Identify all contributing forces.2. Number them as i =12 …n . Call the forces F 1, F 2,...F n .,, 3. Identify the precise points where the forces are applied on the system, and identifyr 2 r j must be athe position vectors r 1,,…,r n respectively for all these points. Each function of q j ‘s.n⎛⎞ 4. For each j , compute the generalized force using Equation 3: Q j =∑F i •⎜∂∂r q i j ⎟. ⎝⎠i =1 Now equate the LHS to RHS for each j . -------------------------------------------------Done--------------------------------------------------­。

三章习题

三章习题

第三章DNA复制一选择题1. Through their experiments with DNA from the bacterium Escherichia coli, Meselson and Stahl showedthat DNA replication is以大肠杆菌DNA为研究对象,Meselson和Stahl通过实验证明DNA复制是A›conservative.✓B›semi-conservative.C›DuplicativeD› dispersive.2. At the conclusion of DNA replication, the two resulting DNA double helices each contain已知DNA的复制方式,那么组成DNA双螺旋的两条链分别是✓A›one parental and one progeny strand.B›two parental or two progeny strands.C›stretches of progeny DNA interspersed with parental DNA along both strands.D›two newly synthesized strands.3. DNA polymerases are enzymes that copy✓A›DNA into DNAB›DNA into RNAC›RNA into DNAD›RNA into RNA.4. To begin DNA replication, a short ___ primer must first be produced. 为了能够起始DNA的复制,一段短的___引物必须预先合成A›DNA✓B›RNAC›polypeptideD›histone5. Which E. coli DNA polymerase has the ability to“proofread” newly synthesized DNA and remove erroneous bases? 在大肠杆菌中,哪一种DNA聚合酶对新合成的DNA具有校正功能,能把错配的碱基移去?A›DNA polymerase I onlyB›DNA polymerase III onlyC›DNA polymerase I and III✓D›all three DNA polymerases have proofreading ability6. During synthesis, all DNA polymerases add nucleotides in which direction?A›from left to rightB›from 3’to 5’✓C›from 5’to 3’D›in more than one direction at a time7. In eukaryotes, DNA replication occurs during which phase of the cell cycle?✓A›SB›G1C›G2D›M8. Which of the following is not required for DNA synthesis reactions?A›dCTPsB›template DNAC›DNA polymerase✓D›calcium ions9. DNA polymerase catalyzes the formation of a phosphodiester bond between aA›5’phosphate and a 5’hydroxyl group.B›3’phosphate and a 5’hydroxyl group.✓C›5’phosphate and a 3’hydroxyl group.D›3’phosphate and a 3’hydroxyl group.10. The sequence of nucleotides in one strand of DNA is 5’-C C A C T G G-3’, What is the sequence of thecomplimentary strand of DNA?A›5’-C C A C T G G-3’B›3’-C C A C T G G-5’C›5’-G G T C A C C -3’✓D›3’-G G T G A C C-5’11. In bacteria such as E. coli, replication of the chromosome is✓A›semidiscontinuous and bi-directional.B›discontinuous and unidirectional.C›continuous and bi-directional.D›semidiscontinuous and unidirectional.12. The 3’ 5’ exonuclease activity associated with DNA polymerase reduces the fre quency of replicationerrors toA›1/10.B›1/1,000.C›1/1,000,000.✓D›1/1,000,000,00.13. The proofreading activity of DNA polymerase removes errant nucleotides from the ___ of a DNAstrand.✓A›3’ endB›5’ endC›3’ and 5’ endD›middle14. On the E. coli chromosome, oriCA›encodes DNA polymerase I.B›is a binding site for histone proteins.✓C›is the start site for replication.D›encodes an RNA primer.15. The enzyme that unwinds the double helix to facilitate replication isA›3 ’ ∙5 ’ ex onuclease.✓B›DNA helicase.C›DNA polymerase.D›topoisomerase.16. When the DNA double helix is replicated, the newly synthesized 5’ ∙3’ strand is considered the ___strand.✓A›leadingB›laggingC›templateD›discontinuous17. Synthesis of the lagging strand occursA›continuously.B›conservatively.✓C›discontinuously.D›semidiscontinuously.18. Which type of DNA is duplicated by rolling circle replication?A›bacteriophage λB›plasmid DNAC›bacteriophage Φ X174✓D›all of the above19. Many types of mammalian cancer cells are notable for their✓A›telomerase activity.B›lack of telomerase activity.C›lack of telomeres.D›increased number of telomeres.20. To determine the number of replication sites in E.coli and whether replication is unidirectional orbidirectional, you examined the results of two different experiments. Both experiments involved growing E.coli in a medium containing radioactive thymidine. What did the addition of thymidine to the medium allow you to observe in both experiments? 为了确定大肠杆菌DNA复制起点的位置以及复制的方向是单向的还是双向的,你调查了两种不同实验结果。

单细胞测序 非模式生物

单细胞测序 非模式生物

单细胞测序非模式生物英文回答:Single-cell sequencing has revolutionized the field of genomics and has allowed researchers to gain insights into the genetic makeup of individual cells. This technology has been extensively used in studying model organisms, such as mice and fruit flies, but it has also been applied to non-model organisms. Non-model organisms refer to species that are not commonly studied in the laboratory and may lack extensive genomic resources.One example of a non-model organism that has been studied using single-cell sequencing is the tardigrade, also known as the water bear. Tardigrades are microscopic animals that are known for their ability to survive extreme conditions, such as high temperatures, desiccation, and radiation. By sequencing the genomes of individual tardigrade cells, researchers have been able to uncover the genetic adaptations that allow these organisms to withstandsuch harsh environments.Another example is the single-cell sequencing of microbial communities in environmental samples. Microbial communities are complex and diverse, consisting of numerous species interacting with each other. By sequencing the genomes of individual cells within these communities, researchers can gain a better understanding of the functional roles of different microbial species and their interactions. This information is crucial for understanding ecosystem dynamics and the potential applications of these microorganisms in various industries, such as bioremediation and biofuel production.Single-cell sequencing of non-model organisms has its challenges. Unlike model organisms, non-model organisms may have larger and more complex genomes, making the sequencing process more difficult and time-consuming. Additionally, non-model organisms may lack reference genomes, which are essential for mapping and analyzing the sequencing data. However, advancements in sequencing technologies and bioinformatics tools have made it possible to overcomethese challenges and obtain valuable insights into the biology of non-model organisms.中文回答:单细胞测序技术已经彻底改变了基因组学领域,并使研究人员能够深入了解单个细胞的基因组构成。

非编码rna注释流程

非编码rna注释流程

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On Some Non-Holonomic SequencesStefan Gerhold ∗Research Institute for Symbolic ComputationJohannes Kepler University Linz,Austriastefan.gerhold@risc.uni-linz.ac.atSubmitted:Oct 15,2003;Accepted:Nov 25,2004;Published:Dec 15,2004Mathematics Subject Classifications:11B37,11R32,11J81AbstractA sequence of complex numbers is holonomic if it satisfies a linear recurrence with polynomial coefficients.A power series is holonomic if it satisfies a linear differential equation with polynomial coefficients,which is equivalent to its coefficient sequence being holonomic.It is well known that all algebraic power series are holonomic.We show that the analogous statement for sequences is false by proving that the sequence {√n }n is not holonomic.In addition,we show that {n n }n ,the Lambert W function and {log n }n are not holonomic,where in the case of {log n }n we have to rely on an open conjecture from transcendental number theory.1IntroductionA sequence u :N →C is called holonomic (P -recursive ,P -finite )over a field K ⊆C if it satisfies a homogeneous linear recurrencep 0(n )u (n )+p 1(n )u (n +1)+...+p d (n )u (n +d )=0n ≥0,(1)where the p k are polynomials with coefficients in K and p d is not identically zero.If K is not mentioned,it is understood to be C .Many combinatorial sequences are holonomic.A formal power series f (z )= n ≥0u (n )z n is holonomic (D -finite ,P -finite )if it satisfiesa homogeneous linear ordinary differential equationp 0(z )f (z )+p 1(z )f (z )+...+p d (z )f (d )(z )=0(2)with polynomial coefficients.Holonomicity of meromorphic functions is defined in the same way.It is well known [8]that a power series is holonomic if and only if its coefficient sequence is.∗Supported by the SFB-grant F1305of the Austrian FWFthe electronic journal of combinatorics 11(2004),#R001There are powerful methods for showing that certain power series are not holonomic.For instance,given that f is holonomic,1/f (if defined)is holonomic if and only if f /fis algebraic,and exp( f )is holonomic if and only if f is algebraic [3,7].Such results can be used to show that a given sequence is not holonomic by applying them to its generating function.For instance,the Bell numbers and the Bernoulli numbers with exponential generating functions exp(e z −1)and z/(e z −1),respectively,can be seen to be non-holonomic in this way.On the sequence level,we have that a sequence that is not eventually zero but has arbitrarily long runs of zeros cannot satisfy a recurrence of the form (1).Furthermore,for every holonomic sequence u there is a constant γsuch that |u (n )|≤n !γfor n ≥2[5,6].In general,this bound is best possible,since {n !m }n is easily seen to be holonomic for integer m .However,none of these techniques apply to the sequences {√n }n ,{log n }n and {n n }n or to the corresponding power series.2Powers of Hypergeometric SequencesA power series f (z )is called algebraic if it satisfies Q (f (z ),z )=0for some non-zero bivariate polynomial Q .All algebraic power series are holonomic [8].The following theorem shows that the analogous statement for sequences does not hold.For instance,putting p =q =1,a 1=2,b 1=1,r =1shows that the sequence {√n +1}n (and hencealso {√n }n )is not holonomic.Theorem 1.Let a 1,...,a p ,b 1,...,b q be pairwise distinct positive integers (possibly p =0or q =0,but not both).Define the sequence {h (n )}n byh (n )=(a 1)n ...(a p )n(b 1)n ...(b q )n n ≥0,(3)where (c )n denotes the rising factorial(c )n =n i =1(c +i −1),and let r ∈Q \Z .Then the sequence {h (n )r }n is not holonomic.Before proving Theorem 1,we briefly comment on its assumptions.Sequences like(3)are called hypergeometric ,where in general the a i and b i may be complex numbers with the exception that no b i can be a negative integer or zero.Such sequences have the property that the quotient h (n +1)is a rational function of n ,and they are obviously holonomic,since they satisfy a linear recurrence of order one with polynomial coefficients.We assume the a i and b i to be pairwise distinct to rule out cases like n n =n !.The fact that a i and b i are integers will be used in an argument from algebraic number theory.Finally,if some a i was negative,the sequence h (n )r would be eventually zero,hence holonomic.Indeed,it is not difficult to see that if two sequences differ only at finitely many entries,one of them is holonomic if and only if the other one is.the electronic journal of combinatorics 11(2004),#R002If a sequence of real numbers is holonomic(over C),it is holonomic over R: dk=0p k(n)u(n+k)=0=⇒dk=0(p k(n))u(n+k)=0.The following lemma generalizes this.Lemma2.Let K be a subfield of C and{u(n)}n be a holonomic sequence with u(n)∈K for all n.Then{u(n)}n is holonomic over K.Proof.Supposedk=0p k(n)u(n+k)=0with p k(n)=m ki=0c ki n i,c ki∈C,(4)and set m=m0+···+m d+d+1.Since u(n)∈K,for each n the recurrence(4)gives rise to a linear equation v Tnc=0with v n∈K m that is satisfied by the coefficient vectorc=(c00,...,c0m0,...,c d0,...,c dmd)T∈C m.We may assume that u is not the zero sequence(otherwise the statement of the lemma is trivial),hence not all v n are the zero vector.Let s be maximal such that there are svectors v n1,...,v nsthat are linearly independent over C.We have s<m since c=0.The linear systemv Tn1c=0...v Tn sc=0with coefficients in K has more unknowns than equations,hence there is a solution0=˜c∈K m.Since any vector v n is a C-linear combination of v n1,...,v ns,the vector˜c satisfiesv T n ˜c=0for all n.We obtain the desired recurrence for u(n)by replacing each c ki in(4)with the corresponding entry of˜c.Another proof of Lemma2has been given by Lipshitz[4].Lemma3.If{u(n)}n and{v(n)}n are holonomic sequences,then their termwise(or Hadamard)product{u(n)v(n)}n is holonomic.In particular,powers of holonomic se-quences with positive integer exponent are holonomic.Proof.See,e.g.,[8].Proof of Theorem1.We assume that h(n)r is holonomic.Write r=αwithβ>0, gcd(α,β)=1and take integersα ,β such thatα α+β β=1.the electronic journal of combinatorics11(2004),#R003Case1:α >0.The sequence h(n)is holonomic.Observe that h(n)−1is of the form(3), too,hence it is also holonomic.By Lemma3,wefind that(h(n)r)α h(n)β =h(n)1−β ββh(n)β =h(n)1/βis holonomic.Case2:α <0.In this case(h(n)r)−α h(n)−β =h(n)β β−1h(n)−β =h(n)−1/βis holonomic.Case3:α =0.This cannot happen sinceβ=±1.We assume that we are in Case1.Case2can be reduced to Case1by replacing h(n) with h(n)−1.For any integer s≥2we defineK s=Q(21/β,31/β,...,s1/β).Then K= s≥2K s is afield.Indeed,K is the intersection of all subfields of C that contain the set{s1/β|s∈N}.Since h(n)1/β∈K for all n,by Lemma2the sequence h(n)1/βsatisfies a recurrencedk=0p k(n)h(n+k)1/β=0n≥0,where the p k are polynomials with coefficients in K.There is an integer s0such that all these coefficients are in K s.For simplicity of notation assumea1=max(a1,...,a p,b1,...,b q).(5) Now choose n0larger than the roots of p d and such that n1=a1+n0+d−1is larger than s0and prime.Thenh(n0+d)1/β=n1/β1 (a1)n0+d−1(a2)n0+d...(a p)n0+d(b1)n0+d...(b q)n0+d1/β=−p d(n0)−1d−1k=0p k(n0)h(n0+k)1/βimpliesn1/β1∈K n1−1.(6) (In the case where the maximum in(5)occurs among the denominator parameters b i it is important to note h(n0+d)1/β=0.)ButK n1−1=Q(ρ1/β1,...,ρ1/βt),the electronic journal of combinatorics11(2004),#R004whereρ1,...,ρt are the primes smaller than n1,and by Galois Theory[2,Section4.12], the degree of thisfield over Q is[K n1−1:Q]=[Q(ρ1/β1,...,ρ1/βt):Q]=βt.Adjoining n1/β1would enlarge the degree toβt+1,hence(6)is impossible.This contradic-tion shows that h(n)r is not holonomic.As an application we show that f(x,n)=1/(x2+n)is not holonomic.We will not need the definition of holonomicity for functions f(x1,...,x r,n1,...,n s)of several continuous and several discrete arguments here,but only the fact that definite integration preserves holonomicity[9].For n≥1we have∞0dxx2+n=1√narctanx√n∞x=0=π2√n,thus1/(x2+n)is not holonomic by Theorem1.3The Sequence log nThe proof of Theorem1immediately yields the following criterion.Proposition4.If there are infinitely many n such thatu(n)/∈Q({u(k)|0≤k<n}),then the sequence{u(n)}n is not holonomic.With this criterion we can prove that{log n}n is not holonomic,assuming the following weak form of Schanuel’s Conjecture.Conjecture5.Suppose thatα1,...,αs∈R are linearly independent over Q,and that eα1,...,eαs are integers.Thenα1,...,αs are algebraically independent.Theorem6.If Conjecture5holds,then{log n}n is not holonomic.Proof.For distinct primesρ1,...,ρs,the numbers logρ1,...,logρs are linearly indepen-dent over Q,since for all c1,...,c s∈Z we have0=si=1c i logρi=log(ρc11...ρc ss)=⇒ρc11...ρc ss=1=⇒∀i:c i=0.(7)By Conjecture5,logρ1,...,logρs are algebraically independent and thus the assumption of Proposition4is satisfied.the electronic journal of combinatorics11(2004),#R0054The Sequence n n and the Lambert W Function Theorem7.For rational numbers a,b with b=0,the sequence{(a+n)bn}n is not holonomic.Proof.By Lemma3we may assume b∈Z.Now the entries of the sequence are in Q, and if it was holonomic,then by Lemma2there would be polynomials p k with rational coefficients,p d=0,such thatdk=0p k(n)(n+a+k)b(n+k)=0n≥0.Multiplying both sides with n−bn yieldsdk=0(n+a+k)bk p k(n) 1+a+k nbn=0.Puttingm=max0≤k≤d(deg p k+bk)and M={k|deg p k+bk=m}, wefind(lc denotes the leading coefficient)dk=0n bk p k(n) 1+a+k nbn=O(n m−1)as n→∞k∈M lc(p k) 1+a+k nbn=O(n−1).Now we take the limit n→∞.k∈Mlc(p k)e b(a+k)=0,hencek∈Mlc(p k)e bk=0.This contradicts the transcendence of e b.The Lambert W function is defined implicitly by the equationW(z)e W(z)=z.In combinatorics−W(−z)is known as the exponential generating function of rooted labelled trees.All information we will need about W(z)can be found in[1].Corollary8.The Lambert W function is not holonomic.the electronic journal of combinatorics11(2004),#R006Proof.This follows from Theorem7with a=0and b=1,Lemma3and the seriesexpansionW(z)=∞n=1(−n)n−1n!z n.Alternatively,a well-known method for proving non-holonomicity[8]can be applied to W(z).The derivatives of W(z)can be written as polynomials in z and W(z)[1], and plugging this representation into(2)yields a non-zero bivariate polynomial Q with 0=Q(z,W(z))=Q(W(z)e W(z),W(z)).This is impossible,since the exponential function is not algebraic.We remark that W satisfies the algebraic differential equationz(W(z)+1)W (z)=W(z).5Open ProblemsWe have proved that{n r}n is not holonomic for r∈Q\Z.It is natural to conjecture that it is not holonomic for r∈C\Z.We did not succeed infinding a proof that{log n}n is not holonomic that does not depend on Schanuel’s Conjecture.Furthermore,there are many other sequences that could be considered.For instance,we do not know of any proof that the sequence of primes is not holonomic.References[1]R.M.Corless,G.H.Gonnet,D.E.G.Hare,D.J.Jeffrey,D.E.Knuth(1996):On the Lambert W Function,Advances in Computational Mathematics,vol.5,329-359[2]L.Gaal(1998):Classical Galois Theory with Examples,AMS Chelsea Publishing[3]W.Harris,Y.Sibuya(1985):The Reciprocals of Solutions of Linear OrdinaryDifferential Equations,Advances in Mathematics58,119-132[4]L.Lipshitz(1988):D-finite Power Series,J.Algebra122,353-373[5]K.Mahler(1976):Lectures on Transcendental Numbers,Lecture Notes in Math-ematics546,Springer[6]E.Maillet(1903):Sur les s´e ries div´e rgentes et les´e quations diff´e rentielles,Ann.Sci.Ecole Norm.Sup.Ser3,3,487-518[7]M.Singer(1986):Algebraic Relations Among Solutions of Linear Differential Equa-tions,Trans.Amer.Math.Soc.2952,753-763the electronic journal of combinatorics11(2004),#R007[8]R.P.Stanley(1980):Differentiably Finite Power Series,binatorics1,175-188[9]Zeilberger,D.(1990):A Holonomic Systems Approach to Special Functions Iden-tities,J.of Computational and Applied Math.32,321-368the electronic journal of combinatorics11(2004),#R008。

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