脑胶质瘤术后联合放化疗效果观察

脑胶质瘤术后联合放化疗效果观察
詹辉;李林繁
【期刊名称】《中国医学创新》
【年(卷),期】2013(10)21
【摘要】目的：探讨脑胶质瘤术后放射治疗联合替莫唑胺化疗的治疗效果。

方法：选取2008年1月-2010年12月本院收治的WHOⅢ~Ⅳ级脑胶质瘤患者54例，随机分为A组和B组各27例，两组均在手术切除肿瘤后给予放射治疗，B组进行放射治疗，A组在放射治疗的基础上使用替莫唑胺化疗。

对比两组的近期疗效、生存率和不良反应。

结果：A组有效率为77.8%；高于B组的48.1%，比较差异有
统计学意义（P<0.05）；两组的1年生存率比较差异无统计学意义（P>0.05），A组的2年生存率为48.1%，高于B组的22.2%，比较差异有统计学意义
（P<0.05）。

A组的不良反应与B组比较，差异无统计学意义（P>0.05）。

结论：脑胶质瘤术后联合放化疗能有效提高治疗效果，延长患者的生存期，值得推广应用。

%Objective:To explore the therapeutic efficacy of brain glioma treated with postoperative radiotherapy combined with temozolomide chemotherapy.Method:54 patients with WHO gr adeⅢ-Ⅳgliomas from January 2008 to December 2010 were divided into group A and group
B,with 27 patients in each group.Both groups were given radiotherapy
after surgical resection of the tumor.Group B was given
radiotherapy,group A was given temozolomide chemotherapy on the basis of radiotherapy.The short-term effect,survival and adverse reactions of two groups were compared.Result:The effective rate of group A(77.8%)was
higher than that of group B(48.1%).The difference was statistically significant between the two groups(P<0.05). The one-year survival rates of the two groups showed no significant difference(P>0.05).The two-year survival rate of group A was 48.1%,which was higher than the 22.2%of group B,the difference was statistically significant(P<0.05).Compared the adverse reactions of group A with group B,the difference was not statistically significant(P>0.05).Conclusion:Postoperative radiotherapy combined with chemotherapy treating glioma can effectively improve the therapeutic effect and prolong the survival,should be widely applied.
【总页数】3页(P107-108,109)
【作者】詹辉;李林繁
【作者单位】广东省高州市人民医院广东高州 525200;广东省高州市人民医院广东高州 525200
【正文语种】中文
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