右美托咪定滴鼻对舒芬太尼引起咳嗽反射的影响

右美托咪定滴鼻对舒芬太尼引起咳嗽反射的影响
毕永红;李冬梅;张瑞芹
【期刊名称】《临床麻醉学杂志》
【年(卷),期】2012(28)12
【摘要】目的观察右美托咪定滴鼻对舒芬太尼引起咳嗽反射的影响.方法择期手术患者100例,随机均分为两组,分别在麻醉诱导前右美托咪定1 μg/kg滴鼻(D组)或等量生理盐水滴鼻(C组),15～30 min后两组均在3s内静脉推注舒芬太尼
0.3μg/kg,观察1 min内咳嗽反射的发生情况.结果 D组咳嗽反射发生率明显低于C组(12％ vs.28％,P＜0.05).两组咳嗽程度和发生时间差异无统计学意义.结论右美托咪定滴鼻可抑制舒芬太尼诱发的咳嗽反射.%Objective To evaluate the effect of mtranasal dexmedetomidine on preventing sulfentanil-induced cough. Methods One hundred patients underwent elective surgery were randomly divided into 2 groups. Patients in group D received mtranasal dexmedetomidine 1 jig/kg while the same volume NS were given nasally (group C) 15-30 min prior to induction of anesthesia. Then, sulfentanil (0. 3 μg/ kg) was infused within 3 seconds. The occurrence, time and severi ty of cough were recorded after sulfentanil bolus. Results The incidence of cough in group D was significantly lower than that in group C(P<0.05). There was no statistical significance in the degree of cough and the occurrence time between the two groups. Conclusion Intranasal dexmedetomidine can prevent sulfentanil-induced cough
【总页数】2页(P1170-1171)
【作者】毕永红;李冬梅;张瑞芹
【作者单位】150086 哈尔滨医科大学附属第二医院麻醉科黑龙江省麻醉与危重病学研究重点实验室;150086 哈尔滨医科大学附属第二医院麻醉科黑龙江省麻醉与危重病学研究重点实验室;150086 哈尔滨医科大学附属第二医院麻醉科黑龙江省麻醉与危重病学研究重点实验室
【正文语种】中文
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