MicroRNA和EMT在结肠癌转移中的作用(英文)

MicroRNA和EMT在结肠癌转移中的作用(英文)
Ping An;Wei Chen;Yu Zhao;Zhongyin Zhou;Hesheng Luo;Ximing Xu
【期刊名称】《中德临床肿瘤学杂志：英文版》
【年(卷),期】2014(0)11
【摘要】Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. Distant metastasis is the major cause of death in patients with CRC. During progression to metastasis in which malignant cells disseminate from the primary tumor to seeding other organs, a multistep process is involved. Cancer cells proliferate, invade microenvironment, enter into the blood circulation, then survive and colonize into distant organs. Micro RNAs(mi RNAs) and epithelial-mesenchymal transition(EMT) are key regulators and mechanism in tumorigenesis and cancer metastasis. We review the roles of EMT and micro RNAs, especially EMT related micro RNAs in the metastatic pathway of CRC. Micro RNAs provide us a set of potential therapeutic applications and molecular target for CRC.
【总页数】4页(P545-548)
【关键词】microRNA;上皮;间质;大肠癌;小分子RNA;微RNA;肿瘤转移;miRNA 【作者】Ping An;Wei Chen;Yu Zhao;Zhongyin Zhou;Hesheng Luo;Ximing Xu
【作者单位】Department of Gastroenterology, Renmin Hospital, Wuhan University;Department of Oncology, Renmin Hospital, Wuhan University 【正文语种】中文
【中图分类】Q522;Q959.402
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