12 CDCS-chapter12
Process.Dynamics.and.Control.Seborg.2nd.Ch12
Closed-loop system is stable for α > −1 Choose τc > 0 The choice of τc does not affect the robustness of the system to changes in α. For τc ≤0, the system is unstable regardless of the value of α. For τc > 0, the system is stable in the range α > −1 regardless of the value of τc.
~ Substitute G+ and f into (12-23):
Y Ysp = (1 − θs ) d
(2τc + θ) s + 1 2 ( τc s + 1)
(6)
The Direct Synthesis design equation is:
1.2 1 0.8 0.6 y 0.4 0.2 0 -0.2 0 Controller for (b) Controller for (c)
(f)
3
6 time
9
12
15
Fig S12.3. Comparison of part (e) PI controllers for unit step disturbance.
Kc =
(b)
1 τ = 0.75 , K θ + τc
τI = τ = 5.5 min,
τD = 0
From Table 12.3 for PID settings for set-point change,
基于主成分分析和聚类分析的李子果实品质综合评价
李可,林籽汐,刘佳,等. 基于主成分分析和聚类分析的李子果实品质综合评价[J]. 食品工业科技,2024,45(8):293−300. doi:10.13386/j.issn1002-0306.2023060002LI Ke, LIN Zixi, LIU Jia, et al. Comprehensive Evaluation of Plums Quality Based on Principal Component Analysis and Cluster Analysis[J]. Science and Technology of Food Industry, 2024, 45(8): 293−300. (in Chinese with English abstract). doi:10.13386/j.issn1002-0306.2023060002· 分析检测 ·基于主成分分析和聚类分析的李子果实品质综合评价李 可1,林籽汐1,刘 佳2,廖茂雯1,袁怀瑜1,梁钰梅1,潘翠萍1,郭南滨3,朱永清1,张国薇2,李华佳1,*(1.四川省农业科学院农产品加工研究所,四川成都 610000;2.四川省农业科学院园艺研究所,四川成都 610000;3.四川省葡萄酒与果酒行业协会,四川成都 610000)摘 要:为了解不同品种李子的品质特性,本文选取12个品种李子作为研究对象,分别从外观、理化及糖酸组成等方面对果实品质进行了对比分析,同时采用主成分分析和聚类分析对李子品质性状进行综合评价。
结果表明,不同品种李子外观、理化和糖酸组成等指标均表现出丰富的多样性。
糖酸组成、色泽、单果重、果实密度和果形指数等是评价李子综合品质的关键性指标。
12个品种中‘紫皇’(ZH )‘圣雪珀’(SXP )‘爱丽丝’(ALS )‘香李’(XL )‘香甜李’(XTL )5个品种综合评分为正值,品质较好。
其中,ZH 和SXP 品质特征为出汁率、可溶性固形物、总糖含量及色泽品质高;ALS 品质特征为总糖、总甜度、甜酸比和糖酸比最高;XL 和XTL 品质特征为可溶性固形物含量、糖酸比、甜酸比高,但出汁率低。
现代大学英语精读2第12课市公开课获奖课件省名师示范课获奖课件
3
Para. 22-23
Instead of criticizing, condemning and complaining, let’s try to understand people.
WB TR
Structure of The Body
• The Body: Let’s learn a few lessons in handling people. (phe question of criticism and
human relations;
•analyse the organization and the language
style of the text;
•learn the related vocabulary and other useful
Background
Genre
Self-help books are books written with the stated intention to instruct any readers on a number of personal problems. They first appeared in the Victorian age and flourished to become a postmodern cultural phenomenon in the late twentieth century - a period marked out by 'the burgeoning literature of self-improvement’.
A Fundamental Technique in Handling People
Unit 12
Theme
现代大学英语精读第二版,unit12,Onwardsandupwards,课文翻译,有删改且符..
onwards and upwards在一个富裕的世界,关于进步的观念则变得贫困。
现状引起的自满和经历带来的痛苦都使得进步的视野越变越狭窄。
取决于你爱看哪种立场的报纸,流行的看法是:尽管科技和GDP发展了,道德与社会却停滞不前,甚至可说是,正在向颓废和野蛮沉沦。
在当今政治的左翼,“进步”这两个字必定带有讽刺性的引号;而对于政治的右翼,“进步人士”也是一个被滥用的术语。
情况也并非一直都是这样糟糕。
长久以来,是求今生圆满,还是求来世完美,一直是不可得兼的难题。
18世纪启蒙运动和19世纪中的乐观主义者相信在全人类总有一天能够在地球上过上幸福和有价值的生活。
正如马达可笔下的亚当,他们对如何改进世界充满了各种想法。
一些人认为上帝应该带来一个新的耶路撒冷,另一些人则想从历史或进化论里查找答案。
有些人认为人民在放任的状态下会自求改善,另一些人则认为只有施加压力人民才会去争取自由;有些人寄希望于民族国家,另一些人则希望民族国家的终结;一些人想要一种完美的语言,另一些人则看重全民教育;一些人将希望寄托于科学,另一些则寄托于商业;有人忠于英明的立法,有人则倾向无政府主义。
智慧的人生伴随伟大的思想倾泻而出。
对于大多数人,问题不是进步是否发生,而是怎如何发生。
关于进步的观念形成了一个社会的大背景。
推到极端,如果一点进步都做不到,利己就必损人。
如果人类的行为不可改造,(那么人同猿人并无差别),社会政策就永远只能是为了把这个猿人关在笼子里。
原则上讲,社会必须能够朝着完美典范前进,诸如自由和平等,否则那些典范就是伪善和自欺欺人。
因此,如果人们对进步失去信念,问题就大了。
如何拾回失去的信念就很值得思考。
行文至此,你们中很多人会忍不住反对。
难道我们周围不都是进步的明证吗?这就是“情况一直变得越来越好”这本书提出的论点。
这本书的作者是已故的Julian Simon and Stephen Moore,当时被聘于华盛顿自由主义者智库卡托研究所。
阿利亚罗K-0169 Rev B 12通道多功能板说明书
12 Channels Multi-Function Board with AMPAL-1010 with AMP for SLSCThis document describes the SLSC AL-1010 with AMP for National Instruments SLSC-12001 chassis.OverviewThe AL-1010 is a 12-channel multi-function module to be connected between the Device Under Test (DUT) and the instrumentation part of the test system.The board is recommended for systems requiring high flexibility on the pin configurations.AL-1010 is made for National Instruments (NI) Switch Load Signal Conditioning (SLSC) system. The board is made to interface with NI PXI and/or Compact-RIO instrumentation devices for the purposes of test and validation of Electronic Control Unit (ECU) software and hardware. Custom device for VeriStand is included for Hardware-In-the-Loop applications.For larger applications, Aliaro Configurator is recommended for channel configuration. Contact Aliaro for additional information.C ontents Overview (1)Description (3)Features (3)Detailed description (4)Installation (5)Electromagnetic Compatibility (5)Unpacking the module (5)Hardware Installation (6)Maintenance (7)Safety (7)Before using the AL-1010 (7)System Check (7)Calibration (7)Specification (8)Definition and conditions (8)Environmental Characteristics (8)Physical characteristics (8)Front connectors (J1 & J2) (9)General specification (10)Fault Insertion (10)Signal conditioning (All channels) (10)Digital I/O (10)Analogue Out – Amplifier (10)Functions (11)LabVIEW (11)Veristand (11)Configuration and Accessories (12)RTI Backplane (12)AL-1010 RTI Terminal Block (14)Safety Guidelines (15)Product Certifications and Declarations (15)CE Compliance (15)Electromagnetic Compatibility Standards (15)Environmental Management (16)Waste Electrical and Electronic Equipment (WEEE) (16)DescriptionThe AL-1010 provide multiple functions for fault insertion, signal conditioning and digital I/O, including pulsed (PWM) signals. The AL-1010 is fitted in pair through the RTI-backplane AL-1010-RTI.The AL-1010 RTI backplane is needed to reach fully flexibility and enables easy connection to NI PXIe and/or Compact-RIO instrumentation devices. Additional with add-on boards the functionality can be expanded further.Features960V, 10A per channel912 independent and isolated channels in three banks9Two common buses per bank with switches to each channel9Brake up switch for each channel9Programmable level threshold on each channel9Parallel connection possibility for high current signals9LabVIEW driver is available.9Custom Device is available.Detailed descriptionFigure 1, AL-1010 Block diagramThe AL-1010 board provides fault insertion, signal conditioning and digital I/O.Fault insertion functions:- Open circuit (DUT to Load)- Short to + and – (DUT to AUX 1 or AUX2)Signal conditioning functions:- Digital input (from DUT) signal conditioning using adjustable threshold (-28 - +28V) - Analogue signal (to DUT) with amplification (4 channels)- Analogue signal (from DUT)Digital I/O functions:- Read digital status (from DUT) using adjustable threshold- Read PWM signals (from DUT) using adjustable threshold (Frequency and duty cycle) - Generate digital signals (to DUT) using AUX1 (+) and AUX2 (-)- Generate PWM signals (To DUT) using AUX1 (+) and AUX2 (-)InstallationElectromagnetic CompatibilityThis product is intended for use in industrial locations. However, harmful interference may occur in some installations, when the product is connected to a peripheral device or test object, or if the product is used in residential or commercial areas. To minimize interference with radio and television reception and prevent unacceptable performance degradation, install, and use this product in strict accordance with the instructions in the product documentation. Furthermore, any modifications to the product not expressly approved by Aliarocould void your authority to operate it under your local regulatory rules.C aution To ensure the specified EMC performance, operate this product only withShielded cables and accessories.Unpacking the moduleCarefully inspect the shipping container and the module for damage.Check for visible damage to the exterior and interior of the damage.If damage appears to have been caused during shipment file a claim with the carrier.Retain the packing material for possible inspection and/or reshipment.If the chassis is damaged, do not install it and contact Aliaro.Hardware InstallationTo set up and use the module you need the following items:Hardwarex SLSC-12001 chassisx SLSC AL-1010 module(s)x SLSC AL-1010 RTIx SLSC AL-1010 RTI CBx Power cablex Power input connectorx Grounding wirex Grounding lugToolsx Screwdriver as needed for your applicationx Wire stripperDocumentationSLSC-12001 Chassis Getting Started Guide and SpecificationsC aution:Do not touch the contacts or remove the I/O boards or cables while the systemis energized.The SLSC chassis and the AL-1010 do not support hot plug-in. The entirechassis must be powered off when a module is inserted or removed.Procedure:1.Power off the main DC power source or disconnect the power source from the chassisbefore installing any modules or RTIs.2.Ensure that the chassis is powered off. The POWER LED should be off. If thePOWER LED is not off, do not proceed until it is off.3.Loosen the screws on the upper rear panel of the chassis.4.Position the RTI backplane at the desired slot and insert the securing screws, but do notfully tighten them.5.Insert a AL-1010 module into the same slot as its corresponding RTI while firmly holdingthe RTI in place until the RTI is firmly connected to the module.6.Repeat steps 4 and 5 for all required RTIs.7.Fully tighten the screws for all RTIs and the upper rear panel of the chassis. Note Waitinguntil all RTIs and modules are installed to fully tighten the screws ensures properalignment for future connections between modules and RTIs.8.Fully tighten the two module mounting screws on each newly installed module.9.Power on the SLSC chassisMaintenanceSafetyC aution Observe all instructions and cautions in the user documentation. Using themodel in a manner not specified can damage the model and compromise the built-insafety protection. Return damaged models to Aliaro for repair.Before using the AL-1010All input characteristics are DC, ACrms, or a combination unless otherwise specified. Maximum switching voltage (any polarity) 1100Vpeak. Every card provides a fully capable fault insertion with external control during simulations or testing. Relays can be configured with Aliaro Configurator, VeriStand and LabVIEWNote Steady state voltages applied to the AL-1010between any two I/O connector pins in excess of the maximum switching voltage specification may damage the module Note Signal connections through the AL-1010are intended to go through the DUTn pin connections. Signal paths that do not use the DUTn pin connections bypass the internal overcurrent limiting features and may exceed the module's thermal capabilities.System CheckThis chapter requires LabVIEW development and installation of LabVIEW drivers.To identify and control that the cards are inserted and work properly with the right firmware, LabVIEW provides basic VI scripts to check SLSC cards mounted in chassis1.Open LabVIEW and select “Help” in the top menu bar and press “FindExamples…” (This opens a new window with pre-built VI (Virtual Instruments) for different applications).2.Switch to the “Search” tab and enter keyword “SLSC” and double click.3.In the new filtered table (to the right) find and select VI called “Configuration.vi”.This VI can located every card(s) that is online in SLSC chassis.4.To find the newly inserted cards look for the SLSC chassis IP-address (in thetable to the right).Count the showing card(s) in the table and make up that there are as manymounted in the SLSC chassis as there are in the VI table for that specific IPaddress. (Can be 1 up to 11 cards per SLSC chassis)CalibrationRecommended warm-up time30 minCalibration interval Not required, recommended on system levelSpecificationDefinition and conditionsWarranted specifications describe the performance of a model under stated operating conditions and are covered by the model warranty.The following characteristic specifications describe values that are relevant to the use of the model under stated operating conditions but are not covered by the model warranty.x Typical specifications describe the performance met by most models.x Nominal specifications describe an attribute that is based on design, conformance testing, or supplemental testing.Specifications are Typical unless otherwise noted.Specifications are valid under the following conditions unless otherwise noted.The AL-1010 module is mounted in an SLSC chassis with the recommended cooling clearances and using a power supply that meets the specifications provided in the chassis user guide. For the entire temperature range of the chassis.Note These specifications only apply to the product as provided by Aliaro. Modifications to the module may invalidate these. Be certain to verify the performance of modifiedmodules.Caution Observe all instructions and cautions in the user documentation. Using themodel in a manner not specified can damage the model and compromise the built-insafety protection. Return damaged models to Aliaro for repair.Environmental CharacteristicsTemperatur e an d HumidityOperating temperature0 °C to 40 °CStorage temperature range-40 °C to 85 °COperating relative humidity range10% to 90%, noncondensingStorage relative humidity range5% to 95%, noncondensingPhysical characteristicsCategory Condition ValueModule Dimensions Excluding front handle144.32mm x 30.48mm x 281 mm(H x W x D)Front Panel Connector1x female Weidmuller 32 highdensityFront connectors (J1 & J2)See fig 1 for description of the functions.C autionThe pins are not indestructible, ports and pins will tare if not treated with care.PinDUT(J1) LOA D (J2) 1DUT Ch 1Load Ch 12DUT Ch 2Load Ch 23DUT Ch 3Load Ch 34DUT Ch 4Load Ch 45DUT Ch 5Load Ch 56DUT Ch 6Load Ch 67DUT Ch 7Load Ch 78DUT Ch 8Load Ch 89DUT Ch 9Load Ch 910DUT Ch 10Load Ch 1011DUT Ch 11Load Ch 1112DUT Ch 12Load Ch 1213DUT_GND AUX 1C 14ISO_GND AUX 2A 15AUX 1A AUX 2B 16AUX 1B AUX 2C(J1)(J2)General specificationC ategory C ondition V alueNo of channels 12No of banks 3Power supply 24VDC, +/-5%Channel to channel isolation (50Ω/100kHz) 40dBMax. Operating Voltage Any pin + 60VMin. Operating Voltage Any pin - 60VFault InsertionCategory Condition Specified value Typical valueMax. continuously current DUT to LoadDUT to AUX 1 /2All other pins 10 A (40A using parallel channels) 10 A (40A using parallel channels)100 mAMax peak current (<100 ms, 25 °C)DUT to LoadDUT to AUX 1/240A/50ms40A/50ms*Notice Exceeding the maximum pulsed current can damage the module. Signal conditioning (All channels)Category ValueThreashold, range -28- +28VThreashold, resolution 0,1VThreshold, bandwidth 20 kHzDigital I/OCategory ValuePWM frequency range 100-65 000 μs (15 hz -10 kHz) PWM frequency resolution 1 usPWM frequency accuracy +/- 25 ppmPWM duty cycle range 10-90 %PWM duty cycle resolution 1 usAnalogue Out – AmplifierCategory ValueNo of channels 4 (DUT ch 1-4)Power supply(Separate isolated supply)24VDC, +/-5%Current drive 200mA per channelFunctionsLabVIEWContact Aliaro Team for separate LabVIEW drivers.(Equal functions to the custom device in Veristand, see below)VeristandThe custom device provides following functions for the AL-1010 board:Parameter Description Unit RangeLoad Connect/disconnect selected channelto Aux 1 (Off/On) 0; 1Aux1 Connect/disconnect selected channelto Aux 1 (Off/On) 0; 1selectedchannelAux2 Connect/disconnectto Aux 2 (Off/On) 0; 1Threshold Sets the digital threshold of selected-28,0+28,0–(V)channel VoltDI Reads the logic value of the channelbased upon the threshold settings (Off/On) 0; 1Amplifier functions (Ch 1-4)Amp-Enable Enables the amplifier function (Off/On) 0; 1foramplificationtheGain Defineseach channel (Off/On) 0; 1PWM functionsPWM_Aux1 Enables PWM function using Aux1for selected channel (Off/On) 0; 1PWM_Aux2 Enables PWM function using Aux1for selected channel (Off/On) 0; 1PWM_Load Enables PWM function using Aux1for selected channel (Off/On) 0; 1PWM_Period Sets period for selected channel Time [μs] 100-65 000 μsDI-PWM_DutyCycle Sets duty cycle when using PWMfor selected channel % 10-100%Configuration and AccessoriesFor most applications, the AL-1010 needs to be configured with a backplane (AL-1010 RTI) combined with a connection block (AL-1010 RTI CB). The AL-1010 provides 2 expansion slots for add-on boards such as customized functionalities needed for the customer’s project.RTI BackplaneThe AL-1010 RTI is used to connect to two (2) SLSC modules (Left and Right) on the same board.Connector pinoutsJ1:1J1:4J1:2J1:3J1:6J1:5J2J3J4J3 Left board / J4 Right board (ERNI 064004 connector)P in S ignal T e rminal P in S ignal T erm i na l A1 Digital in, channel 1 J4:1 B1 Digital in, channel 7 J6:1A2 Digital in, channel 2 J4:2 B2 TS GND J8:4A3 Digital in, channel 3 J4:3 B3 Digital in, channel 8 J6:2A4 Digital in, channel 4 J4:4 B4 TS GND J8:4A5 Digital in, channel 5 J4:5 B5 Digital in, channel 9 J6:3A6 Digital in, channel 6 J4:6 B6 DUT GND J8:3A7 Analog in, channel 7 J2:1 B7 Digital in, channel 10 J6:4A8 Analog in, channel 8 J2:2 B8 DUT GND J8:3A9 Analog in, channel 9 J2:3 B9 Digital in, channel 11 J6:5A10 Analog in, channel 10 J2:4 B10 DUT Ref J8:1A11 Analog in, channel 11 J2:5 B11 Digital in, channel 12 J6:6A12 Analog in, channel 12 J2:6 B12 DUT Ref J8:1A13 DUT Reference J8:1 B13 Analog out, channel 7 J7:1A14 Analog in, channel 1 J3:1 B14 DUT Ref J8:1A15 Analog in, channel 2 J3:2 B15 Analog out, channel 8 J7:2A16 Analog in, channel 3 J3:3 B16 DUT Ref J8:1A17 Analog in, channel 4 J3:4 B17 Analog out, channel 9 J7:3A18 Analog in, channel 5 J3:5 B18 DUT GND J8:1A19 Analog in, channel 6 J3:6 B19 Analog out, channel 10 J7:4A20 Analog out, channel 1 J5:1 B20 TS GND J8:4A21 Analog out, channel 2 J5:2 B21 Analog out, channel 11 J7:5A22 Analog out, channel 3 J5:3 B22 TS GND J8:4A23 Analog out, channel 4 J5:4 B23 Analog out, channel 12 J7:6A24 Analog out, channel 5 J5:5 B24 NC (Internal use) J8:5A25 Analog out, channel 6 J5:6 B25 NC (Internal use) J8:6AL-1010 RTI Terminal BlockThe AL-1010 RTI Terminal Block is used to connect to two (2) SLSC modules (Left and Right) on the same board.System Overview of AL-1010 RTI and Terminal BlocksAL-1010 Terminal block Kadro-B037 AL1010 RTI TBSafety GuidelinesC autionsEnsure that hazardous voltage wiring is performed only by qualified personnel adhering to local electrical standards.Do not mix hazardous voltage circuits and human-accessible circuits on the same module. When device terminals are hazardous voltage LIVE, you must ensure that devices and circuits connected to the device are properly insulated from human contact.All wiring must be insulated for the highest voltage used.Product Certifications and DeclarationsRefer to the product Declaration of Conformity (DoC) for additional regulatory compliance information.To obtain product certifications and the DoC for Aliaro products, visit / certification.CE ComplianceThis product meets the essential requirements of applicable European Directives, as follows: x2014/35/EU; Low-Voltage Directive (safety)x2014/30/EU; Electromagnetic Compatibility Directive (EMC)x2011/65/EU; Restriction of Hazardous Substances (RoHS)Electromagnetic Compatibility StandardsThis product meets the requirements of the following EMC standards for electrical equipment for measurement, control, and laboratory use:x EN 55011-2009 Industrial, scientific and medical equipment - Radio-frequency disturbance characteristics - Limits and methods of measurement CISPR 11:2009x EN 55032:2012 Electromagnetic compatibility of multimedia equipment - Emission requirements CISPR 32:2012x EN 61326-1-2013 Electrical equipment for measurement, control and laboratory use - EMC requirements - Part 1: General requirements IEC 61326-1:2012Environmental ManagementAliaro is committed to designing and manufacturing products in an environmentally responsible manner. Aliaro recognizes that eliminating certain hazardous substances from our products is beneficial to the environment and to Aliaro customers. For additional environmental information, refer to the Minimize Our Environmental Impact web page at /environment.This page contains the environmental regulations and directives with which Aliaro complies, as well as other environmental information not included in this document.Waste Electrical and Electronic Equipment (WEEE)EU Customers At the end of the product life cycle, all Aliaro products must be disposed of according to local laws and regulations.For more information about how to recycle Aliaro products in your region, visit/environment/weee。
2024春高中英语Unit12Innovation单元词汇预通关课件北师大版选择性必修第四册
emerge , decline , boil , explode , regulate , illustrate , preserve
4.Profits have ________ as a result of the recent drop in sales.
5 . You can ________ the temperature in the house by adjusting the thermostat(恒温器).
【答案】4.declined 5.regulate
6.One example will suffice to ________ the point. 7.The sun ________ from behind the clouds. 8.We want to ________ the character of the town while improving the facilities. 【答案】6.illustrate 7.emerged 8.preserve
navy,accuracy,missile,physicist,tube,circuit 7 . We can predict changes with a surprising degree of ________. 8.A defect was found in the electrical ________. 9 . These guns will destroy or disable any incoming ________. 【答案】7.accuracy 8.circuit 9.missile
UNIT 12 INNOVATION
单元词汇预通关
一、中英互译 1.n. 轨道 vi. & vt. 沿轨道运行________ 2.adv. 后来,随后________ 3.adv. 有效率地,高效能地________ 【答案】1.2.subsequently 3.efficiently
剑桥英语第12单元unit12 A song of opposites资料讲解
Homework:
1.听读Unit11--12(5次) 2.抄默big大的. small小的 . tall高的. short矮 的.long长的.happy高兴的. sad难过的.(一行6个默3次) This is
3.背Unit12part1 4.口语作业:用形容词描述物品或人物.
此课件下载可自行编辑修改,仅供参考! 感谢您的支持,我们努力做得更好!谢谢
He is Chenglong . He is short.
tall = t + all = tall short = sh + or + t = short
long 长的
short 短的
long = l + o + ng = long short = sh + or + t = short
boy
Guess, long or short ? This is a ______ruler short
What’s this?
This is a ball.
What’s that?
That is an elephant.
happy sad tall short long big small little
small小的 big大的
big= b + i + g = big small = s + m + all=small
big大的 little小的
big= b + i + g = big little = l + i + tt + le = little
Happy 高兴的
Sad 难过的
happy= h + a+ pp+ y = happy sad = s + a + d = sad
汽车电源树参考设计与自动电子控制系统电源树参考设计 REFRPT001说明书
User’s GuideROHM Solution SimulatorAutomotive Power tree reference design for ADAS/Info-Display applicationREFRPT001 / Load Response for 5.0V power tree sub-circuitThis circuit simulate the load response of REFRPT001 reference design. The REFRPT001 is the reference design, designed for infotainment devices such as vehicle clusters and center information displays, as well as for ADAS ECUs. It is consist of multiple rails of power supply from Battery in the car converting to required voltage and current supply for MCU or SoCs.CANMCUSoCSchottky barrier diode:RBR3LAM60B(3A/60V)+BPrimary DCDC 1A, 2MHz, Low Iq :BD9P105EFV-CPrimaryΠ Type FilterSuperVisor5.0V 3.3V 1.25V 1.0V 5.0VFlagPrimary DCDC 2A, 2MHz, Low Iq :BD9P205EFV-CSecondarySecondary DCDC 2A :BD9S201NUX-CSecondary LDO 0.5A :BD00IA5MEFJ-MSecondary DCDC 2A :BD9S201NUX-CSecondary DCDC 3A :BD9S300MUF-CSecondary DCDC 4A :BD9S400MUF-CSecondary Load Switch Pch :RV4C020ZPHZGLoad Switch++3.3V5.0V5.0V1.25V3.3V1.8V1.5V1.0V3.3VDCDC_P5VDCDC_P3VDCDC_P5V_S1V25LDO_P5V_S3V3DCDC_P3V_S1V8DCDC_P3V_S1V5DCDC_P3V_S1V0DCDC_P3V_PSWSupervisor IC(Voltage monitor,WDT,BIST etc )BD39040MUF-C,BD39042MUF-C (under development)1.5V 1.8V 3.3VIn this circuit, you can observe the fluctuation of the output voltage when the load current is abruptly changed. You can customize the parameters of the components shown in blue, such as VIN, IOUT_SXXX, or peripheral components, and simulate the load response with desired operating condition.General CautionsCaution 1: The values from the simulation results are not guaranteed. Please use these results as a guide for your design. Caution 2: These model characteristics are specifically at Ta=25°C. Thus, the simulation result with temperature variancesmay significantly differ from the result with the one done at actual application board (actual measurement).Caution 3: Please refer to the datasheet for details of the technical information.Caution 4: The characteristics may change depending on the actual board design and ROHM strongly recommend todouble check those characteristics with actual board where the chips will be mounted on.5.0V power tree sub-circuit1. Simulation SchematicFigure 1. Simulation Schematic2. How to simulateThe simulation settings, such as simulation time or convergence options, are configurable from the ‘Simulation Settings’shown in Figure 2, and Table 1 shows the default setup of the simulation.In case of simulation convergence issue, you can change advancedoptions to solve. Default statement in ‘Manual Options’ sets the optionto avoid non-convergence error. You can modify or delete it.Figure 2. Simulation Settings and executionTable 1.Simulation settings default setupParameters Default NoteSimulation Type Time-Domain (Do not change Simulation Type)End Time 5.0msAdvanced options Balanced Convergence AssistManual Options No options SimulationSettingsSimulate3. Simulation ConditionsTable 2. List of the simulation condition parametersInstanceName TypeParameters Default Value Variable RangeUnits Min MaxVBATVoltage Sourcevoltage_level 12 3.5 40 V VEN VoltageSourcePulse_value 12 Pulse_value should be thesame as voltage_level of VBAT V VOCP_SEL VoltageSourcevoltage_level 0 0: Max output current =0.5A, or 5: Max output current=1.0AV VMODE VoltageSourcevoltage_level5 0: Auto mode, or 5: FPWM mode V IOUT_S1V25 Current sourceinitial_value 0 0 1.0 A pulse_value1.0 0 1.0A ramptime_initial_to_pulse 13 No constraint (Note2) µs ramptime_pulse_to_initial13No constraint (Note2)µsStart_delay 1.5 - ms Pulse_width 2.0 - ms Period1.0-sIOUT_S3V3Current source initial_value0 0 0.5 A pulse_value0.5 0 0.5 A ramptime_initial_to_pulse 5 No constraint (Note2) µs ramptime_pulse_to_initial 5 No constraint (Note2) µsStart_delay 1.5 - ms Pulse_width 2.0 - ms Period 1.0 -s(Note 1) This is a constraint of the simulation settings and does not guarantee the operation of the IC.3.1 IOUT_SXXX parameter setupFigure 3 shows how the IOUT_SXXX parameters (Here, XXX: 1V25 or 3V3) correspond to the IOUT_SXXX stimuluswaveform.Figure 3. IOUT_SXXX parameters and its waveformIOUT_S1V25VOUT_P5V_S3V3IOUT_S3V3DCDC_P5V_S1V25Start_delayPeriod (to the next rising edge) Ramptime_initial_to_pulsePulse_valueInitial_valueRamptime_pulse_to_initialPulse_width4. Simulation models4.1 BD9P105EFV-C simulation modelTable 3 and Table 4 shows the model terminal function implemented. Note that BD9P105EFV-C is the behavior model for its load regulation operation, and no protection circuits or the functions not related to the purpose are not implemented.4.2 BD9S201NUX-C simulation modelTable 5 and shows the model terminal function implemented. Note that BD9S201NUX-C is the behavior model for its load/line regulation operation, and no protection circuits or the functions not related to the purpose are not implemented.4.3 BD00IA5MEFJ-M simulation modelTable 6 shows the model terminal function implemented. Note that BD00IA5MEFJ-M is the behavior model for its load/line regulation operation.(Note 4) This model is not compatible with the influence of ambient temperature.(Note 5) This model is not compatible with the external synchronization function.(Note 6) Use the simulation results only as a design guide and the data reported herein is not a guaranteed value.5. Peripheral Components5.1 Bill of MaterialTable 5 shows the list of components used in the simulation schematic. Each of the capacitor and inductor has the parameters of equivalent circuit shown below. The default value of equivalent components are set to zero except for the parallel resistance of L1. You can modify the values of each component.5.2 Capacitor Equivalent Circuits(a) Property editor (b) Equivalent circuitFigure 5. Capacitor property editor and equivalent circuit5.3 Inductor Equivalent Circuits(b) Property editor (b) Equivalent circuitFigure 6. Inductor property editor and equivalent circuitThe default value of PAR_RES is 6.6kΩ.(Note 7) These parameters can take any positive value or zero in simulation but it does not guarantee the operation of the IC in any condition. Refer to the datasheet to determine adequate value of parameters.6. Link to the product information and tools6.1 BD9P105EFV-C6.1.1 Product webpage linkhttps:///products/power-management/switching-regulators/integrated-fet/buck-converters-synchronous/bd9p 105efv-c-product6.1.2 Related documentsThe application notes are available from ‘Documentation’ tab of the product page.6.1.3 Tools and modelsDesign assist tools a re available from ‘Tools’ tab of the product page.The Circuit constant calculation sheet is useful for deciding the application circuit constants.6.2 BD9S201NUX-C6.2.1 Product webpage linkhttps:///products/power-management/switching-regulators/integrated-fet/buck-converters-synchronous/bd9s 201nux-c-product6.2.2 Related documentsThe application notes are available from ‘Documentation’ tab of the product page.6.2.3 Tools and modelsDesign assist tools a re available from ‘Tools’ tab of the product page.The Circuit constant calculation sheet is useful for deciding the application circuit constants.6.3 BD00IA5MEFJ-M6.3.1 Product webpage linkhttps:///products/power-management/linear-regulators/single-output-ldo-regulators/bd00ia5mefj-m-product 6.3.2 Related documentsThe application notes are available from ‘Documentation’ tab of the product page.6.3.3 Tools and modelsDesign assist tools a re available from ‘Tools’ tab of the produc t page.The Circuit constant calculation sheet is useful for deciding the application circuit constants.NoticeROHM Customer Support System/contact/Thank you for your accessing to ROHM product informations.More detail product informations and catalogs are available, please contact us.N o t e sThe information contained herein is subject to change without notice.Before you use our Products, please contact our sales representative and verify the latest specifica-tions :Although ROHM is continuously working to improve product reliability and quality, semicon-ductors can break down and malfunction due to various factors.Therefore, in order to prevent personal injury or fire arising from failure, please take safety measures such as complying with the derating characteristics, implementing redundant and fire prevention designs, and utilizing backups and fail-safe procedures. ROHM shall have no responsibility for any damages arising out of the use of our Poducts beyond the rating specified by ROHM.Examples of application circuits, circuit constants and any other information contained herein areprovided only to illustrate the standard usage and operations of the Products. The peripheral conditions must be taken into account when designing circuits for mass production.The technical information specified herein is intended only to show the typical functions of andexamples of application circuits for the Products. ROHM does not grant you, explicitly or implicitly, any license to use or exercise intellectual property or other rights held by ROHM or any other parties. ROHM shall have no responsibility whatsoever for any dispute arising out of the use of such technical information.The Products specified in this document are not designed to be radiation tolerant.For use of our Products in applications requiring a high degree of reliability (as exemplifiedbelow), please contact and consult with a ROHM representative : transportation equipment (i.e. cars, ships, trains), primary communication equipment, traffic lights, fire/crime prevention, safety equipment, medical systems, servers, solar cells, and power transmission systems.Do not use our Products in applications requiring extremely high reliability, such as aerospaceequipment, nuclear power control systems, and submarine repeaters.ROHM shall have no responsibility for any damages or injury arising from non-compliance withthe recommended usage conditions and specifications contained herein.ROHM has used reasonable care to ensur e the accuracy of the information contained in thisdocument. However, ROHM does not warrants that such information is error-free, and ROHM shall have no responsibility for any damages arising from any inaccuracy or misprint of such information.Please use the Products in accordance with any applicable environmental laws and regulations,such as the RoHS Directive. For more details, including RoHS compatibility, please contact a ROHM sales office. ROHM shall have no responsibility for any damages or losses resulting non-compliance with any applicable laws or regulations.W hen providing our Products and technologies contained in this document to other countries,you must abide by the procedures and provisions stipulated in all applicable export laws and regulations, including without limitation the US Export Administration Regulations and the Foreign Exchange and Foreign Trade Act.This document, in part or in whole, may not be reprinted or reproduced without prior consent ofROHM.1) 2)3)4)5)6)7)8)9)10)11)12)13)。
CDCS 教材习题答案
Appendix BAnswers to review questionsChapter1Basic principles of documentary credits379 Chapter2The sales contract380 Chapter3Documentary credits:types,uses andcharacteristics380 Chapter4Issuing a documentary credit381 Chapter5Advising a documentary credit382 Chapter6Shipment of goods and preparation of documents382 Chapter7Insurance documents382 Chapter8Financial,commercial and other officialdocuments383 Chapter9Examination of documents384 Chapter10Settlement384 Chapter11Other products relating to a documentary credit385 Chapter12Analysis of ICC rules385Chapter1Basic principles of documentary credits1.The correct answer is d.It is only when a complying presentation is made to a nominated bank, confirming bank or issuing bank that honour or negotiation may or will take place.See UCP600sub-articles7(a)and8(a),and article12.2.The correct answer is c.It is the issuing bank that undertakes to honour a complying presentation that is made by or on behalf of the beneficiary.See UCP 600sub-article7(a).3.The correct answer is c.An applicant is not a party to a documentary credit.A documentary credit constitutes an undertaking of a bank(issuing bank)and onceB:Answers to review questions issued cannot be amended or cancelled without the agreement of the beneficiary.4.The correct answer is a.The documentary credit acts as an undertaking addressed to the beneficiary and removes the payment risk of the applicant.5.The correct answer is b.UCP600article2defines’honour’as’to pay at sight if the credit is available by sight payment’;’to incur a deferred payment undertaking and pay at maturity if the credit is available by deferred payment’;and ’to accept a bill of exchange("draft")drawn by the beneficiary and pay at maturity if the credit is available by acceptance’.Chapter2The sales contract1.The correct answer is c.To receive payment in advance removes all payment risk from the beneficiary.2.The correct answer is a.In an open account transaction,an importer is not required to make any payment until the goods and documents are received by it.3.The correct answer is a.In an FOB transaction,freight will be payable at destination(by the importer);in a CIF transaction,freight will be paid before shipment(by the exporter).4.The correct answer is c.UCP600article20requires that a bill of lading indicate that the goods have been shipped on board.Under FOB terms,the bill of lading will be marked freight payable at destination.5.The correct answer is b.The definition of CIF in Incoterms2010is that it stands for the[C]ost of goods,[I]nsurance of the goods and the[F]reight cost for the goods.Chapter3Documentary credits:types, uses and characteristics1.The correct answer is d.What is being described is a revolving credit,ie one that revolves for a similar amount on certain stated conditions.2.The correct answer is c.A credit may provide for the beneficiary to receive an advance paymentChapter4Issuing a documentary creditfor part of the credit value.This was traditionally known as a red clause due to the fact that it was typed onto a letter of credit in red ink.Today, with documentary credits being transmitted primarily by SWIFT message,a clause in red ink is not possible but the term is still referred to by manybankers.3.The correct answer is c.By having a documentary credit confirmed by a bank that is local to the beneficiary,it removes the payment risk of the issuing bank and places it with a bank that is well known to the beneficiary and considered to be financially sound.4.The correct answer is c.The instructing party is the importer or buyer of the goods,services or performance,and they will be known as the applicant.5.The correct answer is b.If the beneficiary provides documents that comply with the terms and conditions of the documentary credit,a confirming bank(if any)or an issuing bank will have an obligation to honour or negotiate.Chapter4Issuing a documentary credit1.The correct answer is a.A nominated bank has no obligation to honour or negotiate under adocumentary credit.An advising bank may or may not be a nominated bank See UCP600article12regarding the role of the nominated bank.2.The correct answer is c.If the charges of an advising or confirming bank are not recoverable from the beneficiary,the issuing bank remains liable.See UCP600article37.3.The correct answer is b.An MT700message is automatically authenticated between the sending and receiving banks.4.A reimbursing bank is under no obligation to honour any claim unlessa reimbursement undertaking has been issued by it and the claimsubmitted by the claiming bank is in conformity with that undertaking.5.The correct answer is b.Acceptance require the placement of an indication of acceptance by the drawee on the face of a draft(bill of exchange).The deferred payment product was developed to cover transactions where a draft was not required or appropriate,ie due to stamp duty fees applying to a draft.B:Answers to review questions Chapter5Advising a documentary credit1.The correct answer is a.The preparation of documents is a task for the beneficiary and other entities that are required to produce documents on their behalf,ie transport and insurance documents.Although some banks provide a document preparation service to their clients,this is not a primary function of a nominated or confirming bank.2.The correct answer is b.As a bank has issued a documentary credit,it is that bank’s payment risk that must be considered by the beneficiary.The issuing bank has, effectively,replaced the payment risk of the applicant with its own. 3.The correct answer is c.This aspect is covered in UCP600article9.Chapter6Shipment of goods and preparation of documents1.The correct answer is c.It will be the commercial documents−invoices,packing lists,transport documents−that will identify the goods.2.The correct answer is d.A CMR note covers the shipment of goods by road.3.The correct answer is c.A bill of lading can,if issued in negotiable form,convey title to thegoods.4.The correct answer is c.This allowance is covered in UCP600sub-article29(a).5.The correct answer is d.UCP600articles19,20and21state that the respective transport document should not contain any indication that it is subject to a charter party.Chapter7Insurance documents1.The correct answer is d.UCP600sub-article28(a)refers to’an insurance document,such as anChapter8Financial,commercial and other official documents insurance policy,an insurance certificate or a declaration under an open cover’.2.The correct answer is b.General average is described as’incurred in the common interests of the ship and cargo and is borne by all the parties interested in the ship and cargo,in proportion to such interests,as determined by persons known as average adjusters.3.The correct answer is b.This minimum requirement is expressed in UCP600sub-article28(f).4.The correct answer is a.A certificate may be replaced by an insurance policy but a cover note isnot acceptable.see UCP600sub-article28(c).5.The correct answer is a.Chapter8Financial,commercial and other official documents1.The correct answer is b.Once accepted by a bank,the amount(or due date)cannot be changed without a form of reacceptance by the accepting bank that indicates an agreement to such action.2.The correct answer is d.A bill of exchange is considered to be afinancial document.3.The correct answer is d.Having an independent organisation assess the quality and/or quantity of the goods being shipped provides a level of comfort to an applicant.4.The correct answer is c.While the amount is an important aspect,it does not form part of the process to determine the date.5.The correct answer is c.The draft does not indicate the date of shipment,therefore from the data on the face of the draft it is impossible to determine the due date.B:Answers to review questions Chapter9Examination of documents 1.The correct answer is a.An issuing bank is under no obligation to contact the applicant for a waiver.See UCP600sub-article16(b).2.The correct answer is d.The term’exporting country’has no meaning under UCP600.Therefore ISBP745,paragraph A19(e)would permit certification to occur in any one of the three stated countries.3.There is no indication that the issuing bank is refusing the documents.This is a primary requirement of UCP600sub-article16(c)(i).4.The correct answer is e.A document may bear the same title,a similar title or have no titleprovided it fulfils the function of the named document.See ISBP745, paragraph M1.5.Having issued a refusal notice according to UCP600sub-articles16(c)(iii)(a)or(b)(and the question indicates option(a)was used),thebank may return the documents at any time thereafter.See UCP600 sub-article16(e).Chapter10Settlement1.The correct answer is c.When a credit is available with a bank other than the issuing bank and the draft is to be drawn on the issuing bank,it must be available by negotiation.2.A reimbursement authorisation is not irrevocable and it can be cancelledat any time.If cancelled,the issuing bank is expected to provide fresh reimbursement instructions.3.The correct answer is d.Any negotiation effected by a confirming bank is without recourse to the beneficiary.See UCP600sub-article8(a)(ii).4.The correct answer is c.The reimbursement condition that is described is to be seen in a credit available by negotiation and not by payment.5.Although the nominated bank had not added its confirmation to thecredit it agreed to accept the draft.Once the draft was accepted,the nominated bank has honoured under the credit.Honour is made without recourse to the beneficiary.Chapter12Analysis of ICC rulesChapter11Other products relating toa documentary credit1.The correct answer is d.The issue of freight charges is otuside the scope of an indemnity between a bank and its client.2.The correct answer is d.An LOI is issued when the original bills of lading,usually charter party bills of lading,are not available at the time of presentation of documents under the credit.3.The correct answer is b.Six to seven years is the usual period associated with‘statute of limitations’that applies in many countries.4.The correct answer is c.The documents that are to be requested do not form part of any syndication agreement.This agreement is more concerned with the amount,expiry period,goods and payment terms.5.The correct answer is b.The shipper’s name is of no concern when seeking the release of the cargo without production of an original bill of lading.Chapter12Analysis of ICC rules1.The correct answer is c.Transferable credits are covered in UCP600article38.2.The correct answer is b.UCP600sub-article14(e)states that for documents other than a commercial invoice,a goods description,if stated,need only be given in general terms not in conflict with the description shown in the credit.3.The correct answer is d.Such a condition is not precise and does not describe how the document is to be issued or signed.ISBP745,paragraph D4states that the document will be examined under UCP600like any other and the condition disregarded.4.The correct answer is c.When a bill of lading indicates a means of pre-carriage,with or without stating a place of receipt,a dated on-board notation is required thatB:Answers to review questions indicates the name of the vessel and the port of loading stated in the credit.5.The correct answer is c.ISBP745,paragraph G3,states that a mere indication of‘Congenbill’is not,in itself,an indication that the bill of lading is subject to a charter party.。
SCI Bias Resistor Transistors数据手册说明书
MUN5312DW1,NSBC124EPDXV6,NSBC124EPDP6 Complementary Bias Resistor TransistorsR1 = 22 k W, R2 = 22 k WNPN and PNP Transistors with Monolithic Bias Resistor NetworkThis series of digital transistors is designed to replace a single device and its external resistor bias network. The Bias Resistor Transistor (BRT) contains a single transistor with a monolithic bias network consisting of two resistors; a series base resistor and a base-emitter resistor. The BRT eliminates these individual components by integrating them into a single device. The use of a BRT can reduce both system cost and board space.Features•Simplifies Circuit Design•Reduces Board Space•Reduces Component Count•S and NSV Prefix for Automotive and Other Applications Requiring Unique Site and Control Change Requirements;AEC-Q101 Qualified and PPAP Capable*•These Devices are Pb-Free, Halogen Free/BFR Free and are RoHS CompliantMAXIMUM RATINGS(T A = 25°C both polarities Q1 (PNP) & Q2 (NPN), unless otherwise noted) Rating Symbol Max Unit Collector-Base Voltage V CBO50Vdc Collector-Emitter Voltage V CEO50Vdc Collector Current − Continuous I C100mAdc Input Forward Voltage V IN(fwd)40Vdc Input Reverse Voltage V IN(rev)10Vdc Stresses exceeding those listed in the Maximum Ratings table may damage the device. If any of these limits are exceeded, device functionality should not be assumed, damage may occur and reliability may be affected.ORDERING INFORMATIONDevice Package Shipping†MUN5312DW1T1G,SMUN5312DW1T1G*SOT−3633,000 / Tape & Reel NSVMUN5312DW1T3G*SOT−36310,000 / Tape & ReelMUN5312DW1T2G,NSVMUN5312DW1T2G*SOT−3633,000 / Tape & ReelNSBC124EPDXV6T1G,NSVBC124EPDXV6T1G*SOT−5634,000 / Tape & Reel NSBC124EPDXV6T5G SOT−5638,000 / Tape & Reel NSBC124EPDP6T5G SOT−9638,000 / Tape & Reel†For information on tape and reel specifications, including part orientation andtape sizes, please refer to our Tape and Reel Packaging Specifications Brochure, BRD8011/D.MARKING DIAGRAMSPIN CONNECTIONS12/R=Specific Device CodeM=Date Code*G=Pb-Free Package (Note: Microdot may be in either location) *Date Code orientation may vary depending upon manufacturing location.SOT−363CASE 419B−02SOT−563CASE 463A(1)(2)(3)(6)(5)(4)SOT−963CASE 527ADM1R12 M GG1612 M G1THERMAL CHARACTERISTICSCharacteristic Symbol Max Unit MUN5312DW1 (SOT−363) ONE JUNCTION HEATEDTotal Device DissipationT A = 25°C(Note1)(Note2)Derate above 25°C(Note1)(Note2)P D1872561.52.0mWmW/°CThermal Resistance,(Note1) Junction to Ambient(Note2)R q JA670490°C/WMUN5312DW1 (SOT−363) BOTH JUNCTION HEATED (Note3)Total Device DissipationT A = 25°C(Note1)(Note2)Derate above 25°C(Note1)(Note2)P D2503852.03.0mWmW/°CThermal Resistance,Junction to Ambient(Note1)(Note2)R q JA493325°C/WThermal Resistance, Junction to Lead(Note1)(Note2)R q JL188208°C/WJunction and Storage Temperature Range T J, T stg−55 to +150°C NSBC124EPDXV6 (SOT−563) ONE JUNCTION HEATEDTotal Device DissipationT A = 25°C(Note1)Derate above 25°C(Note1)P D3572.9mWmW/°CThermal Resistance,Junction to Ambient(Note1)R q JA350°C/WNSBC124EPDXV6 (SOT−563) BOTH JUNCTION HEATED (Note3)Total Device DissipationT A = 25°C(Note1)Derate above 25°C(Note1)P D5004.0mWmW/°CThermal Resistance,Junction to Ambient(Note1)R q JA250°C/WJunction and Storage Temperature Range T J, T stg−55 to +150°C NSBC124EPDP6 (SOT−963) ONE JUNCTION HEATEDTotal Device DissipationT A = 25°C(Note4)(Note5)Derate above 25°C(Note4)(Note5)P D2312691.92.2MWmW/°CThermal Resistance,Junction to Ambient(Note4)(Note5)R q JA540464°C/WNSBC124EPDP6 (SOT−963) BOTH JUNCTION HEATED (Note3)Total Device DissipationT A = 25°C(Note4)(Note5)Derate above 25°C(Note4)(Note5)P D3394082.73.3MWmW/°CThermal Resistance,Junction to Ambient(Note4)(Note5)R q JA369306°C/WJunction and Storage Temperature Range T J, T stg−55 to +150°C1.FR−4 @ Minimum Pad.2.FR−*****×1.0 Inch Pad.3.Both junction heated values assume total power is sum of two equally powered channels.4.FR−4 @ 100mm2, 1 oz. copper traces, still air.5.FR−4 @ 500mm2, 1 oz. copper traces, still air.ELECTRICAL CHARACTERISTICS (T A =25°C both polarities Q 1 (PNP) & Q 2 (NPN), unless otherwise noted)CharacteristicSymbolMinTypMaxUnitOFF CHARACTERISTICS Collector-Base Cutoff Current (V CB =50V, I E =0)I CBO −−100nAdcCollector-Emitter Cutoff Current (V CE =50V, I B =0)I CEO −−500nAdcEmitter-Base Cutoff Current (V EB =6.0V, I C =0)I EBO −−0.2mAdcCollector-Base Breakdown Voltage (I C =10m A, I E =0)V (BR)CBO 50−−VdcCollector-Emitter Breakdown Voltage (Note 6)(I C =2.0mA, I B =0)V (BR)CEO50−−VdcON CHARACTERISTICS DC Current Gain (Note 6)(I C =5.0mA, V CE =10V)h FE 60100−Collector-Emitter Saturation Voltage (Note 6)(I C =10mA, I B =0.3mA)V CE(sat)−−0.25VInput Voltage (Off)(V CE =5.0V, I C =100m A) (NPN)(V CE =5.0V, I C =100m A) (PNP)V i(off)−− 1.21.2−−VdcInput Voltage (On)(V CE =0.2V, I C =5.0mA) (NPN)(V CE =0.2V, I C =5.0mA) (PNP)V i(on)−− 1.92.0−−VdcOutput Voltage (On)(V CC =5.0V, V B =2.5V, R L =1.0k W )V OL −−0.2VdcOutput Voltage (Off)(V CC =5.0V, V B =0.5V, R L =1.0k W )V OH 4.9−−VdcInput Resistor R115.42228.6k WResistor RatioR 1/R 20.81.01.2Product parametric performance is indicated in the Electrical Characteristics for the listed test conditions, unless otherwise noted. Product performance may not be indicated by the Electrical Characteristics if operated under different conditions.6.Pulsed Condition: Pulse Width =300ms, Duty Cycle ≤2%.Figure 1. Derating CurveAMBIENT TEMPERATURE (°C)P D , P O W E R D I S S I P A T I O N (m W )(1) SOT−363; 1.0×1.0 Inch Pad (2) SOT−563; Minimum Pad(3) SOT−963; 100mm 2, 1 oz. Copper TraceFigure 2. V CE(sat) vs. I CFigure 3. DC Current GainFigure 4. Output Capacitance Figure 5. Output Current vs. Input VoltageFigure 6. Input Voltage vs. Output Current1.60.80V R , REVERSE VOLTAGE (V)0.41.22.02.42.83.2C o b , O U T P U T C A P A C I T A N C E (p F )0.010.001I C , COLLECTOR CURRENT (mA)V C E (s a t ), C O L L E C T O R -E M I T T E R V O L T A G E (V )h F E , D C C U R R E N T G A I N10001001I C , COLLECTOR CURRENT (mA)10I C , C O L L E C T O R C U R R E N T (m A )1001010.10.010.001V in , INPUT VOLTAGE (V)V i n , I N P U T V O L T A G E (V )I C , COLLECTOR CURRENT (mA)1010.1100C o b , O U T P U T C A P A C I T A N C E (p F )Figure 7. V CE(sat) vs. I CFigure 8. DC Current GainFigure 9. Output Capacitance Figure 10. Output Current vs. Input VoltageFigure 11. Input Voltage vs. Output Current10320V R , REVERSE VOLTAGE (V)456789 0.001I C , COLLECTOR CURRENT (mA) 0.11V C E (s a t ), C O L L E C T O R -E M I T T E R V O L T A G E (V ) 0.01h F E , D C C U R R E N T G A I NI C , COLLECTOR CURRENT (mA)1I C , C O L L E C T O R C U R R E N T (m A )100101 0.1 0.01 0.001V in , INPUT VOLTAGE (VOLTS)V i n , I N P U T V O L T A G E (V )I C , COLLECTOR CURRENT (mA)1Figure 12. V CE(sat) vs. I CI C , COLLECTOR CURRENT (mA)10010.1Figure 13. DC Current GainFigure 14. Output CapacitanceI C , COLLECTOR CURRENT (mA)10001001I C , COLLECTOR CURRENT (mA)Figure 15. Output Current vs. Input Voltage1001010.10.01V in , INPUT VOLTAGE (V)Figure 16. Input Voltage vs. Output Current0.41.20V R , REVERSE VOLTAGE (V)V C E (s a t ), C O L L E C T O R −E M I T T E R V O L T A G E (V )h F E , D C C U R R E N T G A I N 0.81.62.02.4C o b , O U T P U T C A P A C I T A N C E (p F )I C , C O L L E C T O R C U R R E N T (m A )V i n , I N P U T V O L T A G E (V )1010Figure 17. V CE(sat) vs. I CFigure 18. DC Current GainI C , COLLECTOR CURRENT (mA)I C , COLLECTOR CURRENT (mA)0.010.11Figure 19. Output CapacitanceFigure 20. Output Current vs. Input VoltageV R , REVERSE VOLTAGE (V)V in , INPUT VOLTAGE (V)Figure 21. Input Voltage vs. Output CurrentI C , COLLECTOR CURRENT (mA)V C E (s a t ), C O L L E C T O R −E M I T T E R V O L T A G E (V )h F E , D C C U R R E N T G A I NC o b , O U T P U T C A P A C I T A N C E (p F )I C , C O L L E C T O R C U R R E N T (m A )V i n , I N P U T V O L T A G E (V )SC−88/SC70−6/SOT−363CASE 419B−02ISSUE YNOTES:1.DIMENSIONING AND TOLERANCING PER ASME Y14.5M, 1994.2.CONTROLLING DIMENSION: MILLIMETERS.3.DIMENSIONS D AND E1 DO NOT INCLUDE MOLD FLASH,PROTRUSIONS, OR GATE BURRS. MOLD FLASH, PROTRU-SIONS, OR GATE BURRS SHALL NOT EXCEED 0.20 PER END.4.DIMENSIONS D AND E1 AT THE OUTERMOST EXTREMES OF THE PLASTIC BODY AND DATUM H.5.DATUMS A AND B ARE DETERMINED AT DATUM H.6.DIMENSIONS b AND c APPLY TO THE FLAT SECTION OF THE LEAD BETWEEN 0.08 AND 0.15 FROM THE TIP .7.DIMENSION b DOES NOT INCLUDE DAMBAR PROTRUSION.ALLOWABLE DAMBAR PROTRUSION SHALL BE 0.08 TOTAL IN EXCESS OF DIMENSION b AT MAXIMUM MATERIAL CONDI-TION. THE DAMBAR CANNOT BE LOCATED ON THE LOWER RADIUS OF THE FOOT.DIM MIN NOM MAX MILLIMETERS A −−−−−− 1.10A10.00−−−0.10dddb 0.150.200.25C 0.080.150.22D 1.80 2.00 2.20−−−−−−0.0430.000−−−0.0040.0060.0080.0100.0030.0060.0090.0700.0780.086MIN NOM MAX INCHES0.100.004E1 1.15 1.25 1.35e 0.65 BSC L 0.260.360.462.00 2.10 2.200.0450.0490.0530.026 BSC0.0100.0140.0180.0780.0820.086*For additional information on our Pb−Free strategy and soldering details, please download the ON Semiconductor Soldering and Mounting Techniques Reference Manual, SOLDERRM/D.SOLDERING FOOTPRINT*DIMENSIONS: MILLIMETERS0.306XRECOMMENDEDSIDE VIEWEND VIEWPLANEDETAIL AE A20.700.90 1.000.0270.0350.039L20.15 BSC 0.006 BSC aaa 0.150.006bbb 0.300.012ccc 0.100.0046XH EDIMMIN NOM MAX MILLIMETERS A 0.500.550.60b 0.170.220.27C D 1.50 1.60 1.70E 1.10 1.20 1.30e 0.5 BSC L 0.100.200.301.50 1.60 1.700.0200.0210.0230.0070.0090.0110.0590.0620.0660.0430.0470.0510.02 BSC0.0040.0080.0120.0590.0620.066MIN NOM MAX INCHESSOT−563, 6 LEADCASE 463A ISSUE GNOTES:1.DIMENSIONING AND TOLERANCING PER ANSI Y14.5M, 1982.2.CONTROLLING DIMENSION: MILLIMETERS3.MAXIMUM LEAD THICKNESS INCLUDES LEAD FINISH THICKNESS. MINIMUM LEAD THICKNESS IS THE MINIMUM THICKNESS OF BASE MATERIAL.ǒmm inchesǓSCALE 20:1*For additional information on our Pb−Free strategy and solderingdetails, please download the ON Semiconductor Soldering and Mounting Techniques Reference Manual, SOLDERRM/D.SOLDERING FOOTPRINT*0.080.120.180.0030.0050.007SOT−963CASE 527AD ISSUE EDIM MIN NOM MAX MILLIMETERS A 0.340.370.40b 0.100.150.20C 0.070.120.17D 0.95 1.00 1.05E 0.750.800.85e 0.35 BSC 0.95 1.00 1.05H E ANOTES:1.DIMENSIONING AND TOLERANCING PER ASME Y14.5M, 1994.2.CONTROLLING DIMENSION: MILLIMETERS3.MAXIMUM LEAD THICKNESS INCLUDES LEAD FINISH THICKNESS. MINIMUM LEADTHICKNESS IS THE MINIMUM THICKNESS OF BASE MATERIAL.4.DIMENSIONS D AND E DO NOT INCLUDE MOLD FLASH, PROTRUSIONS, OR GATE BURRS.TOP VIEW SIDE VIEWDIMENSIONS: MILLIMETERSRECOMMENDEDMOUNTING FOOTPRINT*L 0.19 REF L20.050.100.156X *For additional information on our Pb-Free strategy and soldering details, please download the ON Semiconductor Soldering and Mounting Techniques Reference Manual, SOLDERRM/D.ON Semiconductor and are trademarks of Semiconductor Components Industries, LLC dba ON Semiconductor or its subsidiaries in the United States and/or other countries.ON Semiconductor owns the rights to a number of patents, trademarks, copyrights, trade secrets, and other intellectual property. A listing of ON Semiconductor’s product/patent PUBLICATION ORDERING INFORMATION。
综合英语四 Unit 12 A Case of “Seven Bias”教案
教案编号:12.1①鱼在这些岛民的生活中占主要地位。
Fish features very largely in the life of these islanders.②我最喜欢的女主角正在一部新片中担当主角。
My favorite actress was featuring in a new movie.5 Day after day, week after week, this message -that black America is dysfunctional and unwhole -gets transmitted across the American landscape. Sadly, as a result, America never learns the truth about what is actually a wonderful, vibrant, creative community of people.◆dysfunctional:adj. not working normally or properlye.g. children from dysfunctional families有缺陷家庭的子女◆transmit: v1. ~ (sth) (from…) (to…)传送;输送;发射;播送to send an electronic signal, radio or television broadcast, etc.[VN , usually + adv./prep.] signals transmitted from a satellite从卫星传送来的信号The ceremony was transmitted live by satellite to over fifty countries.典礼通过卫星向五十多个国家进行了实况转播。
[V] a short-wave radio that can transmit as well as receive收发两用的短波无线电装置2. [VN] 传播;传染to pass sth from one person to another同义词: transfersexually transmitted diseases性传播疾病Parents can unwittingly transmit their own fears to their children.父母自己的恐惧有可能在无意中感染了孩子。
传统中医学英语词汇
传统中医学词汇是由诺贝笔翻译公司整理一阳"frist yang, Shaoyang Channel"一阴"frist yin, Jreyin Channel"一逆one mista ade in treatment一息 respiration一侧的 unilateral一日量 daily dose一服药 a dose of medicine一夫法 finger breadth measurement一身痛重general pain and heaviness乙癸同源Yi(the live) and Gui)the Kidney) bejing the same source二阴"two lower orifices, ie, the external urethral orifice and the anus"二浊reddish and whitish turbid urine二十八脉twenty-eight kinds of pulse condition二阳并病Shaoyang syndrome complicated by Taiyang syndrome二便不利difficulty in urination and defecation二便失禁urinary and fecal incontinence十问inquire about ten aspects of the patient十剂ten kinds of prescription十八反 eighteen incompatible medicaments十二剂twelve kinds of prescription十二节 twelve joints十二禁 twelve contraindications十二经 twelve regular channels十二时traditional twelve two-hour periods十二脏 twelve internal organs十二怪脉"ten moribund pulses, ten kinds of paradoxical pulse condition"十九畏nineteen nedicaments of nutual antagonism十三科the thirteen medical specialties十四经the fourteen channels十五络(脉)fifteen main collaterals十二节刺twelve methods of needling十二经别branches of the twelve regular channels十二经筋muscle along the twelve regular channels十二皮部 twelve skin areas十六郄穴 sixteen cleft points十四经穴"accupuncture points on the fourteen regular channels, acupoints on regular channels" 十五络穴fifteen main collaterals points十二经动脉arteries of the twelve channels十二井穴 twelve well-points十二经之海sea of the twelve channels丁痂 scar丁奚疳infantile malnutrition due to excessive feeding丁躬势 bowing丁字形骨折 T-shaped fracturre七方"seven prescriptions, Seven formulae"七恶the symtoms and signs indicating poor prognosis of suppurative infections of the exterior part of the body七窍 seven orifices七情 seven emotions七疝seven kinds of hernia七伤 1.seven kinds of impairments 2.seven symptoms suggesting consumption of the kidney-qi七冲门 seven important portals七怪脉"seven moribund pulses, seven paradoxical pulse conditions, seven fatal pulse conditions" 七日风=脐风 neonatal tetanus七星针=梅芬针 seven star needle八纲the eight principal syndromes serving as guidelines in diagnosis八法eight therapeutic methods八廓the eight regions of the white of the eye八溪 eight joints八会穴"eight hui-points, eight influential points"八片锦 different pictures of superficial venules of index finger in children as a reference for diagnosis八纲辨证 analyzing and differentiating pathological conditions in accordance with the eight principal syndromes八脉交会穴 eight confluence points人中疔 boi on philtrum人咬伤human bite; bite by man人迎脉 Renying pulse人背复位 back-carrying reduction人痘接种 human variolation人工牛黄"artificial ox gallstone, Calculus Bovis Factitius"人事不省=神昏 unconsciousness入臼 joint reduction儿风 eclampsia儿病=恶阻儿茶"catechu, blzck catechu, Catechu"儿枕痛 after-pains儿捧母心 breech presentation儿科四大要证four chief diseases in pediatrics九刺nine types of needling九气nine kinds of illness due to disturbance of qi九窍 nine orifices九脏 nine internal organs九虫病 parasitic diseases九窍出血bleeding from the nine orifices九六补泻法nini-six reinforcing-reducing method刀伤 incised wound刀晕 traumatic syncope刀创伤drug for incised wound刀斧伤wound by knife or ax三宝"three exxentialsessence, qi and configurative force"三痹three types of arthralgiz三刺=齐刺 three-stratum puncture三法 "three therapeutic methods-diaphoresis, emesis, and purgation"三伏"1.three periods of dog days, 2.the third period of dog days"三关the three passes三焦"tri-jiao, sanjiao, triple warmer, triple heater"三毛(丛,聚) clump hair三品three grades of medicines三消three types of diabetes三因three categories etiologic factors三虫病 three intestinal parasitoses三春柳=柽柳三焦病disease of tri-jiao三焦经 Tri-jiao Channel三焦咳 tri-jiao cough三棱针"three-deged needle, tri-ensiform needle"三陷证three typesof inward penetration of pyogenic agent三阳病disease of the three yang channels三阳经 three yang channels三阳络 Sanyanglo三阴病diseases of the three yin channels三阴经 three yin channels三阴痉convulsion with symptoms of three yin channels三阴疟 three-yin malaria三板疗法"tri-tabular massage, massage with three Kinds of boards"三部九候three portions and nine pulse-takings7 三焦辨证differentiation of syndrome according to the pathological changes of trijiao 三焦实热heat in tri-jiao of excess type三焦虚寒cold syndromes of deficiency type三阳合病disease involving all three yang channels三点挤压法 three-point pressure method三焦主决渎the triple warmer manages the dredging of water pathway干便 dry stool干疽cellulitis at the anterolateral aspect of the shoulder干咳"dry cough, unproductive cough"干呕 retching干陷dry type of inward penetation of pyogenic agent干癣 1.chronic eczema 2.neurodermatitis干皮 dried bark干血劳emaciation due to blood disorders干胁痛 dry hypochondriac pain干脚气 dry beriberi干霍乱 dr cholera干眼症 xerophthalmia干拔罐 1.dry cupping 2.ordinary cupping土earth(in five elements)土方"folk recipe, local recipe"土疳=针眼 hordeolum土栗infection of the heel土风疮 popular urticaria土生甘sweet flavour is attributed to earth土生金 earth generates metal土克水 earth restricts water土脯子 mantis cheeks土乘水 earth subjugates water土不制水earth fails to control water土生万物earth produces myriads of things土喜温燥earth prefers warmth and dryness土郁夺之Dampness accumulated in the spleen(earth) should be removed8 下胞 Lower eyelid下膊 forearm下法"purgation, purgative therapy"下疳 chancre下膈intake of food in the morning and vomiting in the evening下工"an inferior medical worker, an inexperienced healer"下骨sending down the fishbone下极 1.anus 2.perineum 3.area between inner canthi 4.another name for Hengku下焦"lower-jiao, lower warmer, lower heater, lower burner"下利 diarrgea下迫 tenesmus下气 "1.a therapeutic mithod to keep the adverse qi flowing downward 2.aerofluxus, breaking wind 3.qu of the lower part of the body"下窍 lower orifices下泉 urine下乳=催乳 lactogenesis下脘 1.phlorus 2.Hsiawan下陷=中气下陷 descending disorders下消"diabetes of the kindney type, diabetes incolving the lower-jiao"下搭手lower back cellulitis下丹田lower elixir field下发背"lumbar carbuncle, deep-rooted ulcer in the lumbar region"下焦病 lower-jiao syndrome下马痈acute pyogenic infection of right下石疽indurated mass of knee下牙床 mandible下注疮eczema of shank下病上取treating diseases of the lower part of the body by needling points on the upper part of the body下腹胀气flatulence in the lower abdomen下汲肾阴consumption of the kidney-yin by the excessive heart fire下焦如渎lower-jiao resembling water passages下焦主出The Lower-jiao is in charge of excretory system下厥上竭exharstion of blood with cold limbs下厥上冒 dizzeness caused by adverse flow of qi下利清谷diarrhea with undigested food in the stool下损及上dusease in the lower part affecting the upper下胎毒法dispelling toxic heat and meconium gathered at the fetus for the new born下者举之Sinking disorders should be treated with drugs of raising property; prolapse and ptosis must be treated with the lifting method to reinforce the vital function of the spleen下焦湿热downward flow of damp and heat下利赤白 dysenteric diarrhea下横骨伤fracture of public bone下行通路 descending pathway大夫"an official's title in the feudal age, now used for a doctor in northern China"大肠 large intestine大毒extremely poisonous drugs大方 heavy prescription大分distinct line between large muscles大风= 麻风大腹 upper abdomen大谷large space between muscles大汗"profuse sweating, byperhidrosis, excessive perspiration"大经 rge channels 2.the needling of points on a large channel exhibiting symptoms大厥 coma大络 large collatereals大脉"large pluse, gigantic pulse"10 大衄profuse bleeding from the mouth and nose大气 "atmosphere, air"大溲(解) "defecation, bowel movements"大泻 vigorous reduction大医 respected doctor大针 large needle大眦=内眦 great canthus大节 large joints大产 eutocia大便 feces; stool;defecation大耳 mycrotia大肉 large muscles大嘴 macrostomia大肠病disease of large intestine大肠经"Large Intestine Channel, LI"大肠虚asthenia of large intestine大肠痈 acute appendictis大肠胀flatulence of large intestine大方科speciality of internal medicine大瘕泄 dysentery大结胸large accumulation of phlegm-heat in the chest大头垫 megacaput pad大头风=大头瘟infection with swollen head大腿疽=股疽大腿痈 carbuncle of thigh大泻刺 drainage needling大指间web of great toe大周天large cirde of vital energy大眦漏=漏睛 dacryocystitis大方脉 adult's pulse大出血 "massive hemorrhage,hematorrhea"大肠气 inguinal hernia大麻风 "lepra, leprosy"大便溏 loose stool大补元气invigorating primodial qi大肠寒结constipation due to retention of cold-pathogen in large intestine 大肠滑脱prolapse of rectum大肠气滞qi stagnation of large intestine大肠热结 large intestinal11 大肠湿热 large intestinal damp-heat大肠虚寒asthenia-cold of large intestine大肠液亏deficiency of fluid in large intestine大方脉科 internal medicine大风恶疫=麻风大肉陷下 obvious emaciation and muscular atrophy大头伤寒=大头瘟大眦脓漏dacryocystitis with pyorrhea大气疗法 aerotherapy大风荷毒most dangerous pathogenic factors大肠津亏fluid deficiency in the large intestine大便干结 dry stool大便不通 constipation大便色黑 "black stool, melena"大便如漆 tarry stools大便失禁 incontinence of feces大便困难 dyschesia大便频数 frequency of bowel movement大汗淋漓 profuse perspiration大骨枯槁bones become dry and brittle大渴引饮 extreme thirst大肠主传导large intestine takes charge of transportation大实有羸状appearance of deficiency in extreme excess兀兀欲吐 intense nausea万灵药 panacea寸 a length measurement corresponding to the middle segment of one's middle finger 寸脉 cun pulse寸口脉 cunkou pulse寸白虫 proglottid of tapeworm寸白虫病 taeniasis寸、关、尺 "cun,guan,and chi,inch,bar,and cubit"上胞 upper eye lid上膊 upper arm上膈"postcibal vomiting,vomiting immediately after in gestion"12 上工 "Shang-gong,superior medical worker"上火sufering from excessive internal heat上焦 "upper-jiao,upper warmer,upper heater"上气 1.abnormal rising of qi 2.the upper qi上窍 upper orifices上脘 1.shangwan 2.episgastrium上消diabetes involving the upper-jiao上搭手cellulitis near the scapular region上丹田upper elixir field上腭痈 abscess on palate上耳背 Shangerpei上发背suppurative inflammation of the uppermost part of the back上横骨 sternal notch上马痈left buttock carbuncle上石疽upper stony mass behind the ear上水鱼abscess of the popliteal region上牙床upper dental bed上肢瘫paralysis of upper extremities上焦证upper warmer syndrome上胞下垂 "ptosis,blepharoptosis"上病下取treating diseases in the upper part by managing the lower上膈下膈upper stenosis and lower stenosis上寒下热cold in the upper and heat in the lower上焦病症syndrome of the upper-jiao上焦如雾the upper-jiao resembling a sprayer上焦主纳The upper-jiao is in charge of receiving上骱手法 reduction of dislocation上厥下竭syncope due to exhaustion below上气喘促 shortness of breath上热下寒heat in the upper and cold in the lower上实下虚excess in the upper and deficiency in the lower上损及下the upper effecting the lower上吐下泻 vomiting and diarrhea上下配穴"coordination of the acupionts of the upper with those of the lower, superior-inferior point association"上虚下实deficiency in the upper and excess in the lower上肢不遂moter impairment of the upper extremities上翘下钩势dorso-extension and ventro-flexion exercise口 "mouth,oral cavity"口臭"foul breath, halitosis"口疮 "aphthae,canker sore"口淡 tastelessness口服 "per oral,per os"口疳 aphthae in children口紧=唇紧口噤 "lockjaw, trismus"口苦 bitter taste口软flaccidity of mouth in infants口水 "saliva,spittle"口酸 sour taste口{口呙} wry mouth口咸 salty taste口吃 "stutter,stammer"口糜erosion of mucous membrance of the oral carity口渴 thirst口不仁numbness of mouth口齿科specialty of stomatology and dentistry口甘甜 sweet taste口疳风=舌头泡blisters of the tongue口丫疮"ulcer on the angle of lips,perleche"口中和normal sense of mouth口臭口烂 halitosis and aphthosis口唇发紫 cyanotic lips口唇紧缩=唇紧口干唇裂dry mouth with cracked lips口噤唇青trismus with cyanotic lips口舌糜烂 aphthous stomatitis14 口涎外溢"1.involuntary drooling 2.sialorrhea,ptyalism,sialism,excessive flow of saliva"口眼{口呙}斜"1.facia hemiparalysis deviation of the eye and mouth, wry mouth with distorted eyes"口中无味=口淡flat feeling in mouth口干唇燥 dry mouth and lips口不知谷味loss of appetite口齿咽喉科"1.Department of the Mouth, Teath and Throat 2.specialty of mouth tooth-throat"口沃沫多唾excessive salivation with froth千日疮 verruca vulgaris千岁疮=流注疮 widespread scrofula久咳 chronic cough久痢 protracted drsentery久疟 chronic malaria久痔=肛漏 recto-analfistula久泻 chronic diarrhea久热伤阴persistent fever injuring yin essence久不受孕fail to be impregnated for a long time久泻不止 chromic diarrhea丸剂 "pill,bolus"广肠 sigmoidorectum广疮=杨梅疮 syphilis广明anterosuperior part of the human body丫叉毒丫刺毒pustule in the web between the fiest and second metacarpals亡血 "hemorrhage, bleading"亡阳"yang depletion,yang exhaustion"亡阴"yin depletion,yin exhaustion"亡血家patient with hemorrhagic diathesis尸厥 corpse-like syncope尸体 "corpse,cadaver"尸咽"ophthalmo-oro-genital syndrome,Behcet's syndrome"卫 defensive function卫气 defensive energy卫分证" weifen syndrome,febrile disease at wei phase,syndrom of wei system"卫生局"health bureau, sanitary bureau"卫生学 sanitary science卫气不固=表气不固wei-energy fail to protect the body卫气同病"syndrome of both weifen and qufen,syndrome of both qi and wei systems"卫气管血辨证analysing and differentiating the development of an epidemic febrile disease by studying condition of the four systems女科 "1.women's diseases,gynecology and obster\trics 2.medical department for women,department of gyhecology and obstetrics"女医 1.woman physician 2.physician who attends to women's diseases女劳疸jaundice due to sexual intemperance女劳复relapse of disease due to intemperance in sexual life女子胞 uterus女阴溃疡 ulcerative vulvitis小产 "abortion, miscarriage"小肠the small intestine小毒"d toxicity 2.drugs with a little toxicity,slightly poisonous drugs" 小方 "minor prescription,minor or mild prescription"小分small space between muscles小腹=少腹 lower abdomen小逆minor mistake in treatment小溲 urine小溪=溪谷小心=心包络=命门小眦"lateral canthus, external canthus"小耳 microtia小眼 microphthalmus小嘴 microstomia小便 "urine, urination, micturition"小肠病disorder of the small intestine16 小肠经=手太阳小肠经small intestine channel小肠咳"small intestine cough, cough accompanied by flatulence"小肠疝[气] hernia小肠痈small intestinal abscess小肠胀flatulence of the small intestine小方科 specialty of pediatrics小腹满distension of lower addomen小夹板 splintlet小结胸accumulation of phligm-heat in the chest小伤寒"common cold, common cold of wink-cold type"小舌头 uvula小腿疽=胫疽 leg cellulitis小中风 faint小周天 a small circle of the evolutive小眦漏fistula in the lateral canthus小方脉 infantile pulse小腹疽(痈)carbuncle of lower abdomen小便短赤scanty dark urine小便短小 oliguria小便黄赤 dark urine小便辣痛 ardor urine小便淋沥 dribbling urination小便涩痛difficulty and pain in micturition小便灼热burning sensation during urination小肠实热excessive heat in the small intestine小肠虚寒hypofunction of the small intestine with cold manifestations小儿暴惊sudden fright in children小儿表热exterior-heat syndrome in children小儿虫吐parasite vomiting in children小儿喘急dyspnea in children小儿卒利acute infantile diarrhea in children17 小儿扎目incessant winking of eyes in children小儿发热 fever in children小儿发痧eruptive disease in children小儿疳眼eye disorder due to malnutrition in children小儿寒吐vomiting in children due to cold小儿脚拳 1.infantile pedal spasm 2.spasm of toes in children小儿惊吐vomiting in children induced by frightening小儿咳逆choking cough in children小儿客忤convulsive seizure in duced by terror in children小儿羸瘦 emaciation in children小儿里热endopathic heat syndrowme in children小儿脉法pulse-taking in children小儿热吐vomiting in children due to heat小儿实热heat syndrome of excess type in children小儿食积infantile indigestion with food retention小儿手拳contracture of fingers in children小儿瘫痪 infantile paralysis小儿痰鸣wheezing cough in children小儿通睛"esotropia in children, convergent strabismus in children"小儿吐泻vomiting and diarrhea in children小儿哮喘asthma in children小儿虚热heat syndrome of deficiency type in children小儿遗溺(尿)"1.incontinence of urine in children 2.bed-wetting, nocturnal enuresis in children" 小儿脉科 specialty of pediatrics小户嫁痛pain in vagina小溲热赤dark urine with burning sensation小腿转筋spasm of calf小儿夜啼nocturnal fretfulness infinfants小儿疳积mallnutrition and indigestion syndrome in children18 小儿浮肿edema in children小儿痢疾dysentery in children小儿感冒common cold in children小儿痢证epilepsy in children小儿淋证infection of urinary system in children小儿风水 acute glomerular小儿血虚 anemia in children小儿自汗"spontaneous perspiration in children, hyperhidrosis in children"小儿咳嗽cough in children小儿腹痛abdominal pain in children小儿无耳 anotia小便不利"dysuria, difficulty in micturition"小便不禁=小便失禁"incontinence of urine, aconuresis"小便淋沥dripping discharge of urine小便频数frequency of micturition小儿暑热(渴)证summer fever of children小儿痰湿吐"vomiting in children, due to phlegmdampness"小肠主受盛small intestion has a function of reception小腹中痞块mass in the lower abdomen小儿涕液不收incessant running nose in children小儿推拿疗法 infantile massage小儿囟门不合non-closure of fontanels in infants小儿时行痿 poliomyelitis小儿遗毒烂斑 congenital syphilis飞痘pustules from smallpox vaccination飞法 flying method飞疡(扬)喉hematoma of uvulla飞腾八法=灵龟八法the eight magic turttle techniques飞蚊幻视 muscae volitantes叉喉风acute laryngeal disorder with compressive feeling in the throat19 马牙1.gingival cyst of mucous gland in the newborn 2.yellowish eruptions on the gum of the newborn马桶癣contact dermatitis of buttock马脾风acute asthmatic attack in children马蹄针 staple puncture马刀侠瘿sabre and beadstring scuofulae马蜞咬伤bite by leech子烦 restlessness during pregnancy子户=气穴子淋 stranguria during pregnancy子满 gestational edema子门cervical orifice of uterus子气 1.qi of the child organ 2.edema of legs in pregnancy子舌=重舌子嗽=妊娠咳嗽intractable cough during pregnancy子痫(冒) eclampsia gravidarum子悬"upward flow of fetusqi, feeling of distension in the thorax during pregnancy"子喑"gestational aphonia, aphonia during pregnancy"子痈acute or chronic orchitis and epedidymitis子脏=女子胞医学翻译子肿 edema during pregnancy子宫石 womb stone子宫痛 uterismus子母痔prolapsed internal hemorrhoids子病及母disorder of the child organ affecting the mother organ子肠不收=子宫脱(垂)出 uterine prolapse子盗母气illness of the child organ may involve the mother organ子户肿胀 swelling of vulva子死腹中=死胎不下dead foetus in the uterus子午捣臼zi wu dao jiu needli大夫"an official's title in the feudal age, now used for a doctor in northern China"大肠 large intestine大毒extremely poisonous drugs大方 heavy prescription大分distinct line between large muscles大风= 麻风大腹 upper abdomen大谷large space between muscles大汗"profuse sweating, byperhidrosis, excessive perspiration"大经 rge channels 2.the needling of points on a large channel exhibiting symptoms 大厥 coma大络 large collatereals大脉"large pluse, gigantic pulse"10 大衄profuse bleeding from the mouth and nose大气 "atmosphere, air"大溲(解) "defecation, bowel movements"大泻 vigorous reduction大医 respected doctor大针 large needle大眦=内眦 great canthus大节 large joints大产 eutocia大便 feces; stool;defecation大耳 mycrotia大肉 large muscles大嘴 macrostomia大肠病disease of large intestine大肠经"Large Intestine Channel, LI"大肠虚asthenia of large intestine大肠痈 acute appendictis寸 a length measurement corresponding to the middle segment of one's middle finger 寸脉 cun pulse寸口脉 cunkou pulse寸白虫 proglottid of tapeworm寸白虫病 taeniasis寸、关、尺 "cun,guan,and chi,inch,bar,and cubit"上胞 upper eye lid上膊 upper arm上膈"postcibal vomiting,vomiting immediately after in gestion"12 上工 "Shang-gong,superior medical worker"上火sufering from excessive internal heat上焦 "upper-jiao,upper warmer,upper heater"上气 1.abnormal rising of qi 2.the upper qi上窍 upper orifices上脘 1.shangwan 2.episgastrium上消diabetes involving the upper-jiao上搭手cellulitis near the scapular region上丹田upper elixir field上腭痈 abscess on palate上耳背 Shangerpei上发背suppurative inflammation of the uppermost part of the back上横骨 sternal notch上马痈left buttock carbuncle上石疽upper stony mass behind the ear上水鱼abscess of the popliteal region上牙床upper dental bed上肢瘫paralysis of upper extremities上焦证upper warmer syndrome上胞下垂 "ptosis,blepharoptosis"上病下取treating diseases in the upper part by managing the lower上膈下膈upper stenosis and lower stenosis上寒下热cold in the upper and heat in the lower上焦病症syndrome of the upper-jiao上焦如雾the upper-jiao resembling a sprayer上焦主纳The upper-jiao is in charge of receiving上骱手法 reduction of dislocation上厥下竭syncope due to exhaustion below上气喘促 shortness of breath上热下寒heat in the upper and cold in the lower上实下虚excess in the upper and deficiency in the lower上损及下the upper effecting the lower上吐下泻 vomiting and diarrhea上下配穴"coordination of the acupionts of the upper with those of the lower, superior-inferior point association"上虚下实deficiency in the upper and excess in the lower上肢不遂moter impairment of the upper extremities大肠胀flatulence of large intestine大方科speciality of internal medicine大瘕泄 dysentery大结胸large accumulation of phlegm-heat in the chest大头垫 megacaput pad大头风=大头瘟infection with swollen head大腿疽=股疽大腿痈 carbuncle of thigh大泻刺 drainage needling大指间web of great toe大周天large cirde of vital energy大眦漏=漏睛 dacryocystitis大方脉 adult's pulse大出血 "massive hemorrhage,hematorrhea"大肠气 inguinal hernia大麻风 "lepra, leprosy"大便溏 loose stool大补元气invigorating primodial qi大肠寒结constipation due to retention of cold-pathogen in large intestine 大肠滑脱prolapse of rectum大肠气滞qi stagnation of large intestine大肠热结 large intestinal11 大肠湿热 large intestinal damp-heat大肠虚寒asthenia-cold of large intestine大肠液亏deficiency of fluid in large intestine大方脉科 internal medicine大风恶疫=麻风大肉陷下 obvious emaciation and muscular atrophy大头伤寒=大头瘟大眦脓漏dacryocystitis with pyorrhea大气疗法 aerotherapy大风荷毒most dangerous pathogenic factors大肠津亏fluid deficiency in the large intestine大便干结 dry stool大便不通 constipation大便色黑 "black stool, melena"大便如漆 tarry stools大便失禁 incontinence of feces大便困难 dyschesia大便频数 frequency of bowel movement大汗淋漓 profuse perspiration大骨枯槁bones become dry and brittle大渴引饮 extreme thirst大肠主传导large intestine takes charge of transportation大实有羸状appearance of deficiency in extreme excess 兀兀欲吐 intense nausea万灵药 panacea上翘下钩势dorso-extension and ventro-flexion exercise传统中医学词汇是由诺贝笔翻译公司整理网站:/。
泛用压力调节器产品说明书
R07Miniature Series 07General Purpose Regulator1/8"and 1/4"Port Sizes q Compact designq Full flow gauge portsq Low torque, non-rising adjusting knobq Snap action knob locks pressure setting whenpushed inq Standard relieving models allow reduction of outletpressure even when the system is dead-endedq Can be disassembled without the use of tools orremoval from the air lineTechnical DataFluid: Compressed airMaximum pressure: 20 bar (300 psig)Operating temperature: -20°to +65°C (0°to +150°F) **Air supply must be dry enough to avoid ice formation at temperaturesbelow +2°C (+35°F).Typical flow at 10 bar (150 psig) inlet pressure, 6,3 bar (90psig) set pressure and a droop of 1 bar (15 psig) from set:1/8"ports: 6,5 dm3/s (14 scfm)1/4"ports: 7 dm3/s (15 scfm)Gauge ports:1/8"PTF with PTF main ports1/8"ISO Rc with ISO Rc main ports1/8"ISO Rc with ISO G main portsMaterials:Body: ZincBonnet: AcetalValve: Brass/nitrileValve seat: AcetalElastomers: Nitrile Ordering InformationSee Ordering Information on the following pages.ISO SymbolsDeutsche Dokumentation steht noch nicht zur Verfügung. Bitte wenden Sie sich an unseren zentralen Katalogversand. Tel 02802 49257Zurück zum InhaltsverzeichnisPort Size Model Number Flow† dm 3/s (scfm)Weight kg (lbs)G1/8R07-100-RNKG 6,5 (14)0,19 (0.31)G1/4R07-200-RNKG 7 (15)0,19 (0.31)Ordering Information. Models listed include ISO G threads, relieving diaphragm, 0,3 to 7 bar (5 to 100 psig) outlet pressureadjustment range* without gauge.FLOW CHARACTERISTICSAIR FLOWO U T L E T P R E S S U R Ep s i gTypical Performance Characteristics†Approximate flow at 7 bar (100 psig) inlet pressure, 6.3 bar (90 psig) set pressure and a droop of 1 bar (14.5 psig) from set.Dimensions mm (inches)Panel mounting hole diameter 30 mm (1.19")Maximum panel thickness 0 to 6 mm (0 to 0.25")ItemPart Number All models18-025-003Bracket Kit ReferenceService kit includes slip ring, diaphragm, standard valve seat with o-ring, valve, valve spring.Bracket MountingUse 3 mm (1/8") screws to mount bracket to wall.WarningThese products are intended for use in industrial compressed air systems only. Do not use these products where pressures and temperatures can exceed those listed under ‘Technical Data’.Before using these products with fluids other than those specified, for non-industrial applications, life-support systems, or other applications not within published specifications, consult NORGREN.Through misuse, age, or malfunction, components used in fluid power systems can fail in various modes. The system designer is warned to consider the failure modes of all component parts used in fluid power systems and to provide adequate safeguards to prevent personal injury or damage to equipment in the event of such failure.System designers must provide a warning to end users in the system instructional manual if protection against a failure mode cannot be adequately provided.System designers and end users are cautioned to review specific warnings found in instruction sheets packed and shipped with these products.Water vapor will pass through these units and will condense into liquidif air temperature drops in the downstream system. Install an air dryer ifwater condensation could have a detrimental effect on the application.。
Essential Features and Rational Design00
Molecular CellArticleEssential Features and Rational Designof CRISPR RNAs that Functionwith the Cas RAMP Module Complex to Cleave RNAsCaryn R.Hale,1Sonali Majumdar,1Joshua Elmore,1Neil Pfister,1,5Mark Compton,3Sara Olson,4Alissa M.Resch,4 Claiborne V.C.Glover,III,1Brenton R.Graveley,4Rebecca M.Terns,1,*and Michael P.Terns1,2,*1Department of Biochemistry and Molecular Biology2Department of Genetics3Department of Poultry ScienceUniversity of Georgia,Athens,GA30602,USA4Department of Genetics and Developmental Biology,University of Connecticut Stem Cell Institute,University of Connecticut Health Center, Farmington,CT06030-6403,USA5Present address:Biological Sciences,Columbia University,New York,NY10027,USA*Correspondence:rterns@(R.M.T.),mterns@(M.P.T.)DOI10.1016/j.molcel.2011.10.023SUMMARYSmall RNAs target invaders for silencing in theCRISPR-Cas pathways that protect bacteria andarchaea from viruses and plasmids.The CRISPRRNAs(crRNAs)contain sequence elements acquiredfrom invaders that guide CRISPR-associated(Cas)proteins back to the complementary invading DNAor RNA.Here,we have analyzed essential featuresof the crRNAs associated with the Cas RAMP module(Cmr)effector complex,which cleaves targetedRNAs.We show that Cmr crRNAs contain an8nucle-otide50sequence tag(also found on crRNAs associ-ated with other CRISPR-Cas pathways)that is criticalfor crRNA function and can be used to engineercrRNAs that direct cleavage of novel targets.Wealso present data that indicate that the Cmr complexcleaves an endogenous complementary RNA in Pyrococcus furiosus,providing direct in vivo evi-dence of RNA targeting by the CRISPR-Cas system.Ourfindings indicate that the CRISPR RNA-Cmrprotein pathway may be exploited to cleave RNAsof interest.INTRODUCTIONThe CRISPR-Cas systems are RNA-based immune systems that protect prokaryotes from viruses,plasmids,and other invaders(see recent general reviews Deveau et al.,2010;Hor-vath and Barrangou,2010;Jore et al.,2011a;Karginov and Hannon,2010;Makarova et al.,2011;Marraffini and Son-theimer,2010;Terns and Terns,2011;van der Oost et al., 2009).The clustered regularly interspaced short palindromic repeat(CRISPR)loci found in prokaryotic genomes acquire short fragments of invader sequence( 30–40base pairs in length)that are inserted between short CRISPR repeat sequences.The CRISPR loci give rise to CRISPR RNAs (crRNAs)that each contain an invader-derived(guide)se-quence and interact with CRISPR-associated or Cas proteins to form effector complexes that recognize and silence the cor-responding invader(Brouns et al.,2008;Hale et al.,2008,2009; Jore et al.,2011b;Lintner et al.,2011;Wiedenheft et al.,2011). There are multiple modules of Cas proteins(termed,for ex-ample,Cse and Csy proteins)that can function indepen-dently with crRNAs to effect CRISPR-Cas defense(Haft et al., 2005;Makarova et al.,2006,2011;Terns and Terns,2011); thus distinct CRISPR-Cas pathways function in various prokaryotes.CRISPR-Cas-mediated silencing appears to occur through sequence-specific targeting of RNA or DNA.In Streptococcus thermophilus(Barrangou et al.,2007;Garneau et al.,2010), Escherichia coli(Brouns et al.,2008;Semenova et al.,2011), Staphylococcus epidermidis(Marraffini and Sontheimer,2008), and Sulfolobus solfataricus(Gudbergsdottir et al.,2011;Manica et al.,2011),there is evidence that CRISPR-Cas systems target foreign DNA.Indeed,sequence-specific cleavage of both plas-mid and bacteriophage DNA was recently documented in S.thermophilus(Garneau et al.,2010).At the same time,the Cmr-type crRNA-Cas protein complex from Pyrococcus furiosus specifically cleaves complementary RNAs(Hale et al.,2009). Thus,the various CRISPR-Cas systems(formed by distinct modules of Cas proteins)may function by different mechanisms, including DNA and RNA cleavage.Interestingly,many organisms possess more than one module of Cas proteins and may resist invaders by multiple mechanisms to provide robust protection from diverse invaders.CRISPR RNAs(previously also referred to as prokaryotic silencing[psi]RNAs)are utilized by all versions of the CRISPR-Cas system characterized to date(Brouns et al.,2008;Deltch-eva et al.,2011;Gudbergsdottir et al.,2011;Hale et al.,2009; Lintner et al.,2011;Manica et al.,2011;Marraffini and Son-theimer,2008;Wiedenheft et al.,2011).The CRISPR loci are transcribed from a leader sequence region of100–500base pairs found at one end of each locus(Jansen et al.,2002),where promoter sequences have been identified in a few organisms(Lillestol et al.,2009;Pul et al.,2010).Insertion of new invader-derived sequences into CRISPR loci most frequently occurs immediately downstream of the leader(Andersson and Banfield, 2008;Barrangou et al.,2007;Pourcel et al.,2005;Shah et al., 2009).The CRISPR locus transcripts are cleaved within the repeat sequence to release the individual embedded crRNAs.A series of structurally related proteins from various CRISPR-Cas systems process CRISPR RNA transcripts:Cas6(Carte et al.,2008,2010;Wang et al.,2011),Cse3(Brouns et al., 2008;Gesner et al.,2011;Sashital et al.,2011),and Csy4(Haur-witz et al.,2010;Przybilski et al.,2011).Cleavage within the repeats by these Cas endonucleases produces13intermediate RNAs generally comprised of8nucleotides(nt)of repeat se-quence(called the50tag),a guide sequence,and the remain-ing 20–25nt of repeat sequence at the30end(the30tag) (Brouns et al.,2008;Gesner et al.,2011;Hale et al.,2008;Haur-witz et al.,2010).These13intermediates undergo various amounts of30end trimming(Hale et al.,2008,2009;Jore et al.,2011b;Lintner et al.,2011;Marraffini and Sontheimer, 2008;Wiedenheft et al.,2011).However,an equivalent8nt 50tag is present on mature crRNAs from a variety of bacterial and archaeal species including E.coli(Brouns et al.,2008), S.epidermidis(Marraffini and Sontheimer,2008),Pseudomonas aeruginosa(Haurwitz et al.,2010),P.furiosus(Hale et al.,2008, 2009),S.solfataricus(Lintner et al.,2011;our unpublished data), Sulfolobus tokadai(our unpublished data),and Thermococcus kodakarensis(our unpublished data).In S.epidermis,the50tag of the crRNAs provides for discrimination between self(i.e., the complementary DNA strand in the CRISPR locus,which can base pair with the tag)and nonself(invader DNA,which does not base pair with the tag)(Marraffini and Sontheimer, 2010),but other functions of this crRNA signature sequence are not known.There are three modules of Cas proteins(Cmr,Csa,and Cst) and seven CRISPR loci encoded in the genome of the hyper-thermophilic archaeon P.furiosus.Previously,we identified and characterized a complex comprised of the Cas module RAMP or Cmr proteins(Cmr1-6)and two crRNA species in P.furiosus(Hale et al.,2009).The Cmr-crRNA protein complex is unique among CRISPR-Cas systems characterized to date in that it targets RNA;the complex specifically cleaves RNAs that are complementary to the crRNAs,14nt from the30end of the crRNAs(Hale et al.,2009).Activity was observed in vitro using both native and reconstituted complexes but has not been described in vivo.Here we have investigated the functionality of the crRNAs that direct cleavage by the Cmr complex.Deep sequencing of the RNAs associated with the complex as well as total crRNAs unexpectedly revealed the cleavage of a fortuitous endogenous target RNA by the Cmr complex in vivo.While multiple species of crRNAs are present in P.furiosus,the Cmr complex selectively includes 45and39nt crRNAs regardless of the size of the invader-derived guide sequence encoded in the genome.We show that the8nt50tag sequence is not only necessary for Cmr-directed cleavage but can be used to target the complex to cleave novel RNAs,providing the potential for manipulation of the CRISPR-Cas system for experimental or pharmaceutical gene silencing.RESULTSKey Features of the Cmr Complex RNAsTo delineate functional features of the crRNAs that guide cleavage by the Cmr complex,we isolated active Cmr com-plexes using antibodies against the Cmr2protein.Polyclonal antibodies raised against recombinant P.furiosus Cmr2specifi-cally immunoprecipitated Cmr2(assessed by western blotting, Figure1A),as well as thefive other Cmr complex proteins (Cmr1and Cmr3-6;assessed by mass spectrometry,S.M., C.R.H.,N.P.,M.C.,P.Zhao,L.Wells,R.M.T.,and M.P.T.,unpub-lished data),and39and45nt species of a crRNA(assessed by northern blotting,Figure1B).Moreover,the immunoprecipitated RNA-protein complex replicated the cleavage activity observed with both the chromatographically purified and the reconstituted Cmr complexes(Hale et al.,2009),cleaving a target RNA(com-plementary to one of the endogenous crRNAs)at the two sites located14nt upstream of the30ends of the complementary39 and45nt crRNA species(Figure1C).We probed the nature of the end groups of the crRNAs immu-nopurified with Cmr complexes by end radiolabeling.50end labeling of the39and45nt RNAs was not affected by prior enzy-matic treatment with phosphatase,whereas phosphatase pre-treatment significantly increased30end labeling of the RNAs (Figure1D),indicating that the majority of both species of crRNAs in the Cmr complex contain50hydroxyl and30phos-phate end groups.In order to further characterize the Cmr-associated crRNAs, we deep sequenced the RNAs immunopurified with the com-plex,as well as total P.furiosus small RNAs.We isolated RNAs smaller than 70nt by gel purification,and based on the results of end group analysis(Figure1D),treated the RNAs with phos-phatase to optimize cloning.The cDNA libraries were subject to Illumina sequencing.Figure2A shows the numbers of small RNA sequence reads that map to each of the seven P.furiosus CRISPR loci from the total RNA and Cmr complex samples.A total of2,632,773uniquely mapped small RNA reads were obtained from the total RNA sample,of which54.5%mapped to the CRISPR loci.In contrast,91.2%of the990,060uniquely mapped reads from the Cmr complex sample mapped to the CRISPR loci.The total RNA profiles indicate that RNAs are expressed from all seven P.furiosus CRISPR loci(Figure2A,total RNA),as limited sequencing data had previously suggested(Hale et al., 2009).We analyzed the leader sequences of the seven CRISPR loci and found canonical BRE/TATA promoter sequences at a conserved position within the leaders(Figure2B).A population of RNAs was detected that begins 21nt downstream of these promoter elements(and includes 29nt of the leader sequence at the50end,indicated in red in Figure2B).(These RNAs do not represent the major crRNA species,which are described below.) Thesefindings suggest that the CRISPR loci are transcribed by archaeal RNA polymerase via recognition of the BRE/TATA promoters within the leader sequences.The deep sequencing data also indicate that,in general,crRNAs from the leader-proximal regions of the CRISPR loci are more abundant than crRNAs encoded downstream,as had been hypothesized based on previous data(Hale et al.,2008).The molecular basis for theMolecular CellTarget RNA Cleavage by CRISPR RNA-Cmr Complexesgradient in steady-state levels of the crRNAs from each locus is currently unknown,but could reflect differences in transcription,processing,or stability.The expression gradient is noteworthy because the crRNAs that arise from the leader-proximal end of a CRISPR locus generally target the most recent invaders con-fronted by the system (Andersson and Banfield,2008;Barrangou et al.,2007;Pourcel et al.,2005;Shah et al.,2009).Deep sequencing and northern analysis indicate that a series of species of crRNAs of different lengths are present in P.furiosus ,and that the Cmr complex specifically loads two of these crRNA species.The 50ends of the vast majority of crRNAs in P.furiosus ,in both the total and Cmr complex samples,are comprised of an identical 50end tag sequence (AUUGAAAG)derived from the upstream repeat element (Figure 3A).This end is generated by Cas6cleavage of CRISPR transcripts at this site (Carte et al.,2008,2010;Wang et al.,2011).In total RNA,a mixture of 30ends corresponding to crRNAs 30–70nt in length is observed (Figure 3A),consistent with a series of RNA species detected in total RNA by northern analysis of one of the crRNAs (Figure 1B,total [T]lane).Strikingly,the 39and 45nt crRNA species selec-tively copurify with the Cmr complex (Figures 1B and 3A).The 45nt crRNAs constitute 46%of the crRNAs associated with the Cmr complex,and the 39nt species make up 38%(Figure 3A).Interestingly,the deep sequence analysis indicates that the 30ends of the Cmr complex-associated crRNAs are defined by distance from the 50tag or absolute length of the crRNA(ratherFigure 1.Cmr2Antibodies Immunopurify Active Cmr-crRNA Complexes(A)Cmr2antibodies recognize and specifically immu-noprecipitate 100kD protein.P.furiosus S100extract (T)and PfCmr2antibody immune (I)and preimmune (PI)immunoprecipitation (IP)samples were analyzed by western blotting with Cmr2antibodies.Positions of size markers are indicated.Arrow indicates 100kD protein specifically recognized by immunoblotting and immuno-precipitated by Cmr2antibodies.(B)The Cmr2antibodies immunopurify 45and 39nt crRNAs.RNAs extracted from P.furiosus S100extract (T),and immune (I)and preimmune (PI)immunoprecipitation (IP)samples were analyzed by northern blotting with a probe against P.furiosus crRNA 7.01.The 45and 39nt species of 7.01that are coimmunoprecipitated with the Cmr2antibodies are indicated by arrows.Sizes of RNA markers (M)are shown.(C)Immunoprecipitated Cmr complexes cleave a target RNA.50end-labeled 7.01target RNA (complementary to crRNA 7.01,indicated with arrow)was incubated in the absence (–)of proteins or in the presence of immune (I)and preimmune (PI)immunoprecipitation samples.Cleavage products are marked with asterisks.(D)Coimmunopurified crRNAs possess 50OH and 30phosphate ends.Immunoprecipitated crRNAs were iso-lated and 50or 30labeled with (+)and without (–)prior phosphatase treatment.The 45and 39nt crRNA species are indicated by arrows,and RNA size markers (M)are shown.than,for example,by the length of the guide sequence encoded in the CRISPR locus or by position relative to the 30repeat element).Guidesequences in P.furiosus CRISPRs are most commonly 37nt long,in which case the 45nt crRNA species is comprised of an 8nt repeat tag sequence and a full 37nt guide sequence.(The 39nt species simply lacks 6nt of the guide sequence at the 30end;see Figure 3A.)However,some guide sequences are as short as 34nt and as long as 59nt in P.furiosus ,and Cmr complex crRNAs are nonetheless consistently 39and 45nt in length.For example,while three of the first five guide sequences in CRISPR locus 4are 37nt long,the second guide sequence in the locus (termed 4.02)is 35nt;yet the 4.02crRNAs found in the Cmr complex are 45and 39nt in length (Figure 3B).The 45nt 4.02crRNA includes 2nt of the downstream repeat sequence.Conversely,the fifth CRISPR 4guide sequence is 1nt longer than standard (38nt),and the 45nt 4.05crRNA lacks the last encoded nucleotide of the guide sequence (Figure 3B).Similarly,the first guide sequence in CRISPR 1is 48nt long (11nt longer than is typical),and the 45nt 1.01crRNA found in the Cmr complex includes only 37nt of the 48nt guide sequence (see Figure 4B).Thus,regardless of the size of the guide sequence encoded in the genome,the crRNAs of the Cmr complex are comprised of an 8nt 50repeat tag and a 37or 31nt guide sequence.Cleavage of a Complementary RNA In VivoVery few RNAs were detected that were transcribed from the opposite (nonleader)ends of the CRISPR loci in P.furiosus ;Molecular CellTarget RNA Cleavage by CRISPR RNA-Cmr Complexeshowever,we did detect significant antisense transcription from an apparently fortuitous promoter within CRISPR locus 1.A BRE/TATA promoter sequence is present in the antisense orientation within the second guide sequence of CRISPR locus 1,and a significant number of antisense RNAs that begin distinctly 21nt downstream of the promoter are present in the sequence from the total RNA sample (see Figure S1,blue reads,available online).The number of antisense RNA reads is approx-imately one-third the number of reads observed for the sense strand crRNA reads (crRNA 1.01;Figure S1,red reads).Northern analysis reveals a series of antisense RNAs up to 140nt in length in total P.furiosus RNA (Figure 4A,1.01antisense,T lane).The antisense CRISPR transcripts found in P.furiosus would be predicted to be recognized and targeted by Cmr complexes containing the crRNA encoded on the opposite strand of CRISPR locus 1(crRNA 1.01).Previous in vitro studies estab-lished that the Cmr complex cleaves complementary RNAs 14nt upstream of the 30ends of the 39and 45nt crRNAs (Hale et al.,2008).Accordingly,in this case,the 1.01crRNAs would be predicted to generate 50products of 45and 39nt (as well as 30products of various lengths)upon cleavage of theantisenseFigure 2.Deep Sequencing Profiles of crRNAs Found in Total P.furiosus RNA and Immunopurified Cmr Complexes(A)Total and Cmr-associated small RNA se-quencing reads that map to the seven P.furiosus CRISPR loci.Y axis scale bars indicate the number of reads (thousands)that contain nucleotides that map to the indicated position within the CRISPR locus.Red indicates sequence reads that map to the sense strand relative to the CRISPR leader region,and blue corresponds to reads that map to the antisense strand.The positions of CRISPR repeats are shown as black bars below the graph.An x axis scale of 1kb is indicated.Images were generated using the UCSC archaeal genome browser (Karolchik et al.,2003).(B)Putative promoter sequences found in the P.furiosus CRISPR leader regions.Alignment of the regions upstream of the first repeat of each P.furiosus CRISPR locus is shown.The repeats are shown in blue,the initial transcribed regions (detected by sequencing)are shown in red,the potential TATA elements are shown in pink,the potential BRE elements are underlined,and other leader sequences are shown in black.Consensus BRE/TATA elements are shown above the alignment.transcripts.And indeed,distinct anti-sense RNAs of 45and 39nt were ob-served in northern analysis of the total RNA (with a probe to the 50region of the antisense transcript;Figure 4A,1.01anti-sense,T lane),suggesting that the Cmr complex targets and cleaves the endoge-nous CRISPR1antisense transcript in P.furiosus .We also found in both RNA sequencing and northern analysis that the 45and 39nt putative 50cleavage products are specifi-cally coimmunopurified with the Cmr complex (Figure 4A,1.01antisense,immune [I]versus preimmune [PI]lanes;and Fig-ure 4B,blue reads,versus Figure S1,blue reads),suggesting that the products remain associated with the complex to some extent following cleavage.The 45and 39nt antisense RNAs do not possess the 50repeat tag sequence,which we hypothe-size is important for recognition and function of crRNAs with the Cmr complex.However,because of the coincidence in the size of these RNAs with Cmr complex crRNA species,we tested the possibility that the antisense RNAs are functional guide RNAs.We found that the immunopurified Cmr complexes do not cleave a target RNA complementary to the antisense RNAs,indicating that the antisense RNAs do not guide cleavage by the Cmr complex (Figure 4C,antisense RNA target).At the same time,the immunopurified complexes do cleave an RNA corresponding to the 140nt antisense RNA transcript,gener-ating 50products of the same sizes observed in vivo (45and 39nt;Figure 4C,crRNA target).Together,the findings indicate that the Cmr complex recognizes and cleaves endogenous complementary RNAs in vivo.Molecular CellTarget RNA Cleavage by CRISPR RNA-Cmr ComplexesThe CRISPR Repeat Tag Sequence Is Required for Functional Cmr Complex crRNAsIts conservation suggests that the 50CRISPR repeat tag is an important element of functional Cmr complex crRNAs.We inves-tigated the importance of the tag by testing several tag sequence mutants for the ability to guide cleavage by reconstituted Cmr complexes.Removal of the repeat tag sequence from crRNA 7.01eliminates cleavage of a complementary target RNA (Fig-ure 5A).Substitution of the entire tag sequence to its comple-ment (AUUGAAAG /UAACUUUC)or of the first two nucleo-tides of the tag sequence (AUUGAAAG /GAUGAAAG)also prevents function of the crRNA,as does the addition of a G at the 50end of the tag (Figure 5B).Analysis of CRISPR locus 8provided further insight into the basis for the importance of the 50repeat tag in vivo.crRNAsFigure 3.Cmr Complex crRNAs Contain a Conserved 8nt 50Sequence Tag and Are of Defined 39and 45nt Lengths(A)The 50and 30ends of Cmr-associated crRNAs are defined relative to the upstream repeat element.Graphs show the percentage of crRNAs sequenced in total P.furiosus RNA (upper panel)and immunopurified Cmr complexes (lower)with ends that map at indicated posi-tions relative to the 50repeat-guide junction (arrowhead).The Cmr-associated crRNA species are illustrated below with 50repeat tag (black)and guide sequence (green)indicated.RNAs from CRISPR8were excluded from this analysis due to a repeat sequence polymorphism (see text).Read numbers analyzed (n)are indicated.(B)The length of the Cmr complex crRNAs is independent of the length of the genome-encoded guide sequence.Deep sequence profiles of crRNAs 4.01–4.05in total P.furiosus RNA (upper panel)and immunopurified Cmr complexes (lower)are shown relative to repeat (black)and guide (green)sequence elements (see also Fig-ure 2A).Dashed lines mark the 30ends of the 45nt crRNA species.(The 50end and 30end of the 39nt species are also indicated for crRNA 4.01.)The sequence at the 30guide-repeat junction is shown below for crRNAs 4.01,4.02,and 4.05.Guide sequences are shown in green,and repeat sequences are shown in black.Arrowheads indi-cate the locations of the 30ends of the 45nt crRNA species.from locus 8were significantly underrepre-sented in the Cmr complex (Figure 2A and Fig-ure S2).The reduced presence of CRISPR locus 8RNAs in the Cmr complex correlates with a difference in the 50repeat tag found on these RNAs.Most of the crRNAs from locus 8possess a 7nt AUUGAAG (rather than 8nt AUUGAAAG)repeat tag due to a variation in the repeat sequences within this CRISPR locus (Figure 5C).The exception is crRNA 8.11(the last crRNA encoded by locus 8),which retains the canon-ical 8nt repeat tag sequence,and this crRNA is selectively enriched in the Cmr complex rela-tive to the other crRNAs from CRISPR locus 8(Figures 2A and 5C).Together,these resultsindicate that the CRISPR repeat tag is critical for the formation of functional Cmr complexes by crRNAs.For CRISPR-Cas systems that target DNA,the 50repeat tag on the crRNAs provides a key function in distinguishing self from nonself.In organisms with these systems,it is important for crRNAs to avoid targeting the complementary DNA sequence found in the host CRISPR locus itself,and evidence indicates that in these systems potential targets with complementarity to the tag sequence (found in the CRISPR locus but not in invader targets)are not silenced (Marraffini and Sontheimer,2010).We tested the effect of target complementarity to the tag sequence on RNA cleavage by the Cmr complex,and observed no signifi-cant reduction in activity (Figure 5D).The antisense transcript that is cleaved in vivo by the Cmr complex also is complementary to the tag of crRNA 1.01(Figure 4).Thus,RNA targeting by theMolecular CellTarget RNA Cleavage by CRISPR RNA-Cmr ComplexesCmr complex does not require a lack of complementarity between the target and the crRNA repeat tag.crRNAs Can Be Engineered to Direct the Cmr Complex to Cleave Novel Target RNAsOur findings indicate that a 50repeat tag is necessary for a crRNA to function to guide cleavage by the Cmr complex.To determine whether the Cmr complex can be directed to cleave novel target RNAs by engineered crRNAs,we designed crRNAs with the 50AUUGAAAG tag sequence and guide sequences complemen-tary to a random target sequence (X 0)or to a sequence near the 50end of the b -lactamase (bla )mRNA.Cmr complexes reconsti-tuted with the crRNA designed to cleave the random target sequence specifically cleaved the X 0target RNA but not a bla target sequence (Figure 6A).Similarly,the crRNA designed against the 50region of the bla mRNA directed cleavage of the bla target sequence but not the X 0target RNA (Figure 6A).The cleavage product sizes are consistent with target cleavage 14nt from the 50ends of the crRNAs.The 50bla crRNA and a crRNA designed against an internal region of the bla mRNA were also tested for the ability to direct cleavage in the context of the full-length bla mRNA.The 50radiolabeled bla mRNA ( 860nt)was cleaved by Cmr complexes reconstituted with both blacrRNAs,yielding products of the expected sizes ( 17nt for the 50bla crRNA and 236nt for the internal bla crRNA)(Figure 6B).These results demonstrate that the Cmr complex can be directed to cleave novel target RNAs at a desired site by crRNAs designed with an appropriate repeat tag sequence and a guide region complementary to the target cleavage site.DISCUSSIONThe RNA Targeting Branch of the CRISPR-Cas Immune SystemThere is tremendous diversity in the CRISPR-Cas immune path-ways that protect prokaryotes from invaders (recently reviewed in Deveau et al.,2010;Garrett et al.,2011;Horvath and Barran-gou,2010;Jore et al.,2011a;Karginov and Hannon,2010;Makarova et al.,2011;Marraffini and Sontheimer,2010;Terns and Terns,2011;van der Oost et al.,2009).The different CRISPR-Cas systems are populated by distinct modules of proteins,and the mechanisms of key steps in the pathways,in-cluding crRNA biogenesis and invader silencing,can be funda-mentally different.In this work,we investigated the Cmr effector complex,which is unique among systems characterized to date in that it targets RNAs rather than DNAs (Hale et al.,2009).ThisFigure 4.Antisense RNA Found in P.furiosus Is Cleaved by the Cmr-crRNA Complex(A)Antisense RNA from the region of crRNA 1.01is detected by northern analysis,and two species are associated with the Cmr complex.Northern analysis of total P.furiosus RNA (T)and RNAs isolated from immune (I)or preimmune (PI)Cmr2immunopurifications was probed for antisense (left panel)or sense 1.01crRNAs (right panel).Colored dots indicate the primary species of antisense RNAs (blue dots)and crRNAs (red dots)specifically associated with the Cmr complex (and correspond with dots in panel B).Sizes of radio-labeled RNA marker (M)are noted.(B)The two antisense RNAs associated with the Cmr complex map downstream of a potential fortuitous promoter and correspond to the ex-pected products of crRNA 1.01-guided cleavage.Deep sequencing profiles of Cmr-associated crRNAs in the region encoding crRNA 1.01are shown.Red indicates RNAs transcribed from the leader region,and blue corresponds to reads from the opposite strand.The positions of CRISPR re-peats (black),guide sequences (green),and BRE/TATA promoters (red and blue)are indicated.A blue line represents the apparent full-length antisense RNA observed by deep sequencing total RNA (see Figure S1).Cleavage of the anti-sense RNA by the Cmr complex 14nt from the 30ends of the 45and 39nt species of crRNA 1.01(red dots)would produce antisense RNA products of the sizes observed by deep sequencing and northern analysis (blue dots).(C)Immunopurified Cmr complexes cleave the antisense RNA.Radiolabeled RNA targets for the antisense RNAs (left panel)and crRNAs (right panel)were incubated in the absence (–)of proteins or in the presence of immune (I)or preimmune (PI)immunourified preparations,and the products were analyzed following denaturing gel electrophoresis.(The target for the crRNAs is 140nt in length and corresponds to the full-length antisense RNA;see C.)The cleavage products obtained by incubation of the crRNA target with the immunopurified Cmr complex (asterisks)are approximately the same sizes as the endogenous antisense RNA species that are immunopurified with the Cmr complexes (A,left panel).Noncontiguous lanes from the same gel are indicated by dashed lines.Molecular CellTarget RNA Cleavage by CRISPR RNA-Cmr Complexes。
02 电气规范和标准IEC60364
电流对人和牲畜的效应-一般情况
电流对人和牲畜的效应-特殊情况
电流对人和牲畜的效应-通过人和 牲畜的电流效应
外壳的防护等级 (IP 代码)
用于电动机回路的中压熔断器的技 术规范
低压系统设备的绝缘配合
低压开关设备和控制设备的尺寸- 开关设备和控制设备的装置中用于 支撑电气器件的标准安装轨道
/cnwiki/%E7%94%B5%E6%B0%94%E8%A7%84%... 2014/4/30
电气规范和标准 - 电气装置应用(设计)指南
IEC 60364-7-702 IEC 60364-7-703 IEC 60364-7-704 IEC 60364-7-705
标准电压
电力变压器-温升
电力变压器-绝缘水平、电介质试 验和在空气中的外部间隙
电力变压器-耐受短路电流能力
电力变压器-噪声水平的确定
半导体变换器-一般要求和线换流 变换器
电气继电器
中压开关-额定电压大于 1 kV 和小 于 52 kV 的中压开关
低压熔断器-一般要求
低压熔断器-非熟练人员用熔断器 的附加要求 (家用和类似应用的熔断 器)
中压熔断器-限流熔断器
电缆-额定电流的计算-额定电流 方程式 (100% 负荷率)和损耗计算- 通论
建筑物电气装置
建筑物电气装置-基本原则
建筑物电气装置-安全保护-电击 防护
建筑物电气装置-安全保护-热效 应防护
建筑物电气装置-安全保护-过电 流保护
建筑物电气装置-安全保护-电磁 干扰和电压扰动的防护
/cnwiki/%E7%94%B5%E6%B0%94%E8%A7%84%... 2014/4/30
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12Document characteristics and preparing documents12.1 IntroductionAs discussed in Chapter 7, an issuing bank of a documentary credit gives an undertaking that it will honour a complying presentation made under it.A presentation will be made by, or on behalf of, the beneficiary.An issuing bank assumes the risk of the applicant becoming insolvent and is responsible for the recovery of any funds from the applicant in respect of any payment to a beneficiary or a nominated bank. In order to cover this risk, an issuing bank may take security from the applicant, for example in the form of a cash deposit. More often, though, it will take comfort from any security obtained from the transport document tendered under adocumentary credit.12: Document characteristics and preparing documentsSome transport documents, such as bills of lading, can provide transfer of title or confer ownership of the goods to the bank. In these circumstances, an issuing bank may have the means of obtaining possession of the goods for resale in the event of a default by the applicant. When an issuing bank cannot obtain title to the goods, it may try to exercise some other measure of control over the goods in transit.In addition to a transport document, a documentary credit will also require the presentation of one or more of the following documents:insurance documents – providing cover against risk to the goods during their carriage from the beneficiary’s premises / country of export to the country of import / applicant’s premises;commercial documents – identifying and describing the goods, as stipulated in the documentary credit; andofficial documents – evidencing compliance with the requirements of the country of export or the country of import.It may also require the presentation of a financial document – that is, a draft (or bill of exchange) that determines the amount to be drawn under the documentary credit by way of honour or negotiation. The underlying characteristics of all of these documents are outlined in this chapter. Finally, the beneficiary will arrange for the documents required under the documentary credit to be presented to the nominated bank or the issuing bank. This chapter concludes with an explanation of this presentation process and explains the options available to a beneficiary should the documents be determined as discrepant.12.2 Preparing transport documentsThe cycle of a transport document comprises three important stages:1. understanding the requirements, as stipulated in the documentarycredit;2. creating the transport document; and3. managing its handling from creation through to delivery of the goods.Preparing transport documents12.2.1 Understanding the requirements asstipulated in the documentary creditFrom the point of view of both the beneficiary and the concerned banks, this is by far the most important stage of the cycle. It is essential that a beneficiary understands the precise nature of the transport document required under the documentary credit. In order to achieve this understanding, a beneficiary must carefully read the wording of the transport document requirement in the documentary credit. The beneficiary should then refer to the sale contract or proforma invoice agreed with the applicant and ensure that the required document matches that which was expected. If necessary, the beneficiary should clarify any concern with the applicant and, where appropriate, seek an amendment to the documentary credit.It can also be useful to refer to the advising bank, because the bank may be willing to seek clarification from the issuing bank on behalf of the beneficiary. If issues are resolved in this way, there is less chance of documents being unnecessarily refused by any of the banks.The transport document required by the documentary credit should also reflect the routing that is shown in Field 44 of the SWIFT MT700 message. If only Fields 44E and 44F are completed, the required document should be a bill of lading, non-negotiable sea waybill, charter party bill of lading or air transport document.If only Fields 44A and 44B are completed, the required document should be a multimodal transport document, road, rail or inland waterway transport document, or a courier receipt, postal receipt or certificate of posting.If any three or four of Fields 44A, 44E, 44F and 44B are completed, the required document should be a multimodal transport document.12.2.2 Creating the transport documentIn the case of carriage of goods by sea, traditionally when the mate of the vessel receives the goods on behalf of the master, a mate’s receipt is issued. This document provides evidence of receipt on behalf of the vessel. It also shows that the goods have been received in good order and condition, or contains a statement as to the condition of the cargo if there are any apparent issues with the goods or their packaging.The document will also indicate the number of packages, marks and numbers, and the name of the shipper.12: Document characteristics and preparing documentsWhen a forwarding agent or carrier completes the documentation for the bills of lading, just before or at the time the vessel is due to sail, the bills of lading are signed and delivered in exchange for the mate’s receipt.In the case of other transport documents, there is rarely an intermediate stage, during which air, road, rail, inland waterway, courier, and parcel post transport documents are issued in exchange for acceptance and / or receipt of the goods.12.2.3 Managing its handling from creationthrough to delivery of the goodsThe transport document flow is illustrated in Figure 12.1.Figure 12.1 Transport document flowFigure 12.1 shows that the flow of a document, for example a bill of lading, is from the carrier to the beneficiary (shipper / seller) and then to the nominated bank. After handling a presentation, in terms of its nomination (with or without acting on its nomination to honour or negotiate) and which would include the bills of lading, the nominated bank forwards the presentation to the issuing bank.Types of transport document The issuing bank examines the documents against the documentary credit and, in the case of conforming documents, honours in accordance with its terms and conditions. The applicant receives the documents in exchange for reimbursement or in terms of any arrangement made with the issuing bank.12.3 Types of transport documentAs previously mentioned, the type of transport document used is determined by the method of carriage and the routing of the goods. The next section outlines the characteristics of each type of transport document.12.3.1 Multimodal transport documentsA multimodal transport document is a document that covers at least two different modes of transport. Multimodal transport has developed rapidly over recent decades.In particular, it allows goods to be sent from the beneficiary’s premises to those of the applicant, using a single document. In these cases, a multimodal transport operator (MTO) or combined transport operator (CTO) undertakes contractual responsibility for ensuring that the goods are carried to their destination. The goods can be transported by a combination of different modes of transport, for example any combination of road, sea, air and rail. Under UCP 600, article 19, an MTO or CTO is not authorised to sign a transport document in either capacity. While it may be a transport operator, it must sign either as an agent of a named carrier or of the master, or in the capacity of carrier.The shipper (the party sending the goods and usually the beneficiary) concludes a single contract of carriage with the MTO or CTO. The MTO or CTO makes its own contractual arrangements with the individual carriers for each successive part of the carriage. The MTO or CTO need not operate its own means of transport. For this reason, MTOs or CTOs are sometimes described as ‘contractual carriers’ to distinguish them from those carriers that physically transport the goods.Multimodal transport techniques have a number of potential advantages, as follows.They can help to reduce transit times – an MTO or CTO and the shipper are able to select the quickest mode of transport for each leg of the journey, without diminishing the operator’s responsibility for the whole journey. Because an MTO or CTO deals with transport, carriers, storage and clearing agents on a daily basis on behalf of many shippers,12: Document characteristics and preparing documentsthe various associated activities can be completed more speedily at the different ports and points of despatch and arrival.They can lower costs – an MTO or CTO may be able to command more competitive prices across all activities, including loading, unloading, storage and carriage.At the same time, both the applicant and beneficiary will benefit from having a single arrangement to monitor. When multimodal transport involves an element of ocean carriage, the goods are generally placed in containers. In a few cases, the goods are loaded onto a barge at a river point, and the barge (often referred to as a ‘LASH’ barge) is stowed on the ocean-going vessel at the sea port. ‘Roll-on, roll-off’ (ro-ro) techniques are also employed on shorter voyages. In these cases, a lorry (truck) or trailer carrying the goods is loaded onto the vessel, or rail car, or wagon.12.3.1.1 Title, negotiability and transferIf the carriage involves, for example, travel over land and then by sea, the transport document is usually titled a ‘combined’, ‘through’ or ‘multimodal’ transport document. In such circumstances, where a vessel is the mode of transport for the last leg of the carriage, trade practice is to use it as a negotiable document capable of transferring title by delivery in the same way as a bill of lading. Negotiability and title are subject to any previous defect in title, such as that the multimodal transport document has not been stolen or fraudulently altered.Under a documentary credit, an issuing bank will usually require a multimodal transport document to evidence that the goods are consigned to its order, or ‘to the order of the shipper’ (or ‘to order’), and to be endorsed by the shipper in blank or to its order.It should be noted that neither UCP 600 nor ISBP 745 makes any reference to title or negotiability. This is left to the applicable law.12.3.1.2 Control over goodsIf an issuing bank seeks to obtain security through the goods by means of a multimodal transport document, it will insist that all originals of the document are presented to it.If, however, the carriage does not involve a final leg by sea to the country of import, the multimodal transport document may not be classed as a negotiable document capable of transferring title by delivery, or by delivery and endorsement (whichever applies).Types of transport document 12.3.1.3 Delivery of goodsIf a multimodal transport document is issued to order of a named entity, or ‘to order’, or ‘to order of shipper’, delivery of goods will be made against the surrender of an original multimodal transport document, or against a shipping guarantee or indemnity to facilitate the release of goods should the transport document be absent or lost. If a multimodal transport document is not issued in the manner described earlier – that is, if it is consigned to a named party (known as a ‘straight consigned document’) – goods will be delivered to the named consignee against simple identification, or againsta delivery order or release note from the named consignee.12.3.2 Bills of ladingThe bill of lading first appeared in its modern form in the mid-nineteenth century and became the principal document used in maritime transport. Bills of lading are normally issued by, or on behalf of, a named carrier. 12.3.2.1 Title, negotiability and transferOver the years, it has become trade practice to use and accept bills of lading as transferable documents of title. Today, their legal status as negotiable documents of this type is specifically set out in the legislation of most countries. This means that when a bill of lading is issued in negotiable form, ownership of the goods to which the bill of lading relates can be conveyed by transferring the document from one person to another. Negotiability and title are subject to any previous defect in title, such as that the bill of lading has not been stolen or fraudulently altered.An issuing bank will usually require bills of lading to be made out to its order, or ‘to order of the shipper’ (or ‘to order’), and to be endorsed in blank or to its order. Rights under such bills of lading can then be transferred by endorsement and delivery. Regulations in certain countries require bills of lading to be issued to the order of the nominated bank and to be duly endorsed to the issuing bank. Depending upon the form of endorsement, a further endorsement by the issuing bank may be required before delivery of the document to the applicant. An issuing bank that requires the issuance of bills of lading to its order should be aware of the potential liability for charges, port dues and other expenses.It should be noted that neither UCP 600 nor ISBP 745 make any reference to title or negotiability. This is left to the applicable law.12: Document characteristics and preparing documents12.3.2.2 Control over goodsIf an issuing bank seeks to obtain security through the goods by means of bills of lading, it will insist that all originals are presented to it.12.3.2.3 Delivery of goodsAgainst surrender of an original bill of lading The carrier is entitled to effect delivery of goods to the holder of one original bill of lading (duly endorsed, where necessary). If more than one original bill of lading is issued, the carrier is not concerned with the whereabouts of the others. In delivering goods to the holder of the one original bill of lading or the only original bill of lading, the carrier fulfils its primary obligation under its contract of carriage.However, if a bill of lading is consigned to a named party (a straight consigned document), goods will be delivered to the named consignee against simple identification, or against a delivery order or release note from the named consignee.Against an indemnity or shipping guarantee If the goods have arrived at the port of discharge and the bills of lading have not been received, the carrier may agree to deliver the goods against an indemnity or shipping guarantee. The carrier will almost always insist upon the issuing bank either countersigning or actually issuing the indemnity or guarantee. This is because the carrier is subsequently liable to a holder of an original bill of lading and, as such, liability is not restricted in time. This guarantee will normally be issued in the format required by the carrier, and may be unlimited as to amount and have no expiry date, depending on the requirements of the carrier.It is important that the consignee arranges to clear the goods as quickly as possible after their arrival at the port of discharge or liabilities may be incurred to the port authorities for demurrage. ‘Demurrage’ may be defined as a charge levied by the port authorities for a failure to remove the goods within a specified time. Delays in receiving the original bills of lading may be the result of short sea journeys, delays in the beneficiary presenting documents to a nominated bank, or documents being held by a nominated or issuing bank because discrepancies have been found. Indemnities (or shipping guarantees) are covered in Chapter 20.Types of transport document12.3.3 Non-negotiable sea waybillsA non-negotiable sea waybill is to be consigned to a named party – usually the issuing bank in a documentary credit transaction. They are also referred to as ‘straight consigned transport documents’.Non-negotiable sea waybills are used because a traditional bill of lading, the surrender of which is required before the carrier will deliver goods, is not practical for short sea journeys. This is because often the goods will arrive at the port of discharge before the underlying bills of lading have been received through banking channels; as a result, the clearance of goods can be delayed. The applicant may then incur demurrage charges and could also suffer loss in the sale of goods as a result of such delay. The non-negotiable sea waybill was created to aid the transition process from paper-based bills of lading to electronic forms of bills of lading – that is, to allow the release of the goods without the need for the surrender of an original document to the carrier or its agent.12.3.3.1 Title, negotiability and transferA non-negotiable sea waybill is not a document of title and is not a negotiable document.12.3.3.2 Control over goodsIf an issuing bank wishes to exercise control over the goods, it will insist upon being named as the consignee. This is sometimes subject to the consignor waiving its right to change the named consignee prior to delivery. This can be achieved by the non-negotiable sea waybill containing what is known as a ‘lien’ clause – that is, a clause indicating that the carrier or its agent will not change the name of the consignee without the submission of all of the original non-negotiable sea waybills for alteration and authentication by the carrier or its agent.12.3.3.3 Delivery of goodsDelivery is made by the carrier or its agent to the named consignee and is not dependent upon the surrender of an original non-negotiable sea waybill. Delivery may also be made to a named entity against a delivery order or release note from the named consignee.12: Document characteristics and preparing documents12.3.4 Charter party bills of ladingShipments of large bulk consignments – that is, of commodities such as oil, rice, wheat, sugar, steel, etc – will be made on a vessel hired specifically for the shipment. This hiring arrangement is called a ‘charter party’. Such arrangements may be concluded either for a period of time or for a single voyage. The party hiring the ship concludes a contract of carriage with the owner or its agent. This is known as the ‘charter party contract’, and will include items such as the time period for the charter, the basis for loading and unloading the cargo, the ports of loading and discharge, and the party responsible for the freight cost.Once shipment has been effected, a charter party bill of lading is issued and signed by the owner, master or charterer, or its respective agent.The precise legal effects of charter parties vary from one jurisdiction to another. A particular problem is that, in many cases, rights conferred by a charter party bill of lading take second place to any rights that the shipowner may have against a charterer. For example, if a charterer defaults on payment to the owner, the latter may be able to recoup its losses by selling the goods. A bank is generally not aware, nor does it need to be aware, of the terms of even the most commonly used charter party contracts. A charterer may be the applicant (in an FOB contract) or the beneficiary (in a CFR or CIF contract).There is also uncertainty as to how clauses of the charter affect the legal rights of the holder of a charter party bill of lading. Under UCP 600, except as required or permitted by a documentary credit, bills of lading indicating that they are issued subject to a charter party are not acceptable. If a charter party bill of lading is required or acceptable, banks will not examine the underlying charter party contract even if it is listed as a required document.12.3.5 Air transport documentsThe transport of goods by air gives rise to the issuance of an air transport document, more commonly known as an ‘air waybill’ or ‘air consignment note’. The carrier, or its agent, issues such documents as evidence that the goods have been accepted for carriage.12.3.5.1 Title, negotiability and transferAn air transport document is not a document of title and is not a negotiable document.Types of transport document 12.3.5.2 Control over goodsControl over goods rests with the shipper as consignor and the carrier up to the point of delivery. To allow control over the goods, UCP 600, sub-article 23(a)(v), requires that the presented air transport document be the original for consignor or shipper. This should prevent the consignor or shipper from exercising its right to request the carrier to change the destination or the consignee of the goods. The carrier or its agent should agree to such a request only if the original for consignor or shipper is handed over to it for amendment and authentication.In most cases, if the bank wishes to take control of the goods, it will be the named consignee on the air transport document.12.3.5.3 Delivery of goodsThe carrier will deliver goods to the consignee, as shown on the air transport document, against proper identification, or against a delivery order or release note from the named consignee.12.3.6 Road, rail or inland waterway transportdocumentsTransport documents covering the despatch of goods by rail or by road are known as ‘rail consignment notes’ or ‘road consignment notes’, respectively. Road consignment notes are also known as ‘truck waybills’ or ‘Convention Merchandises Routiers (CMR) notes’ (after the 1956 United Nations Convention on the Contract for the International Carriage of Goods by Road).These documents provide evidence that the carrier has received the goods and of the address of the consignee.12.3.6.1 Title, negotiability and transferRoad, rail or inland waterway transport documents are not documents of title and are not negotiable documents. The exception is when an inland waterway transport document is issued in the form of a bill of lading – that is, to order of a named entity, or ‘to order’ or ‘to order of the shipper’.12.3.6.2 Control of goodsThe control over the goods remains in the care of the carrier.12: Document characteristics and preparing documents12.3.6.3 Delivery of goodsDelivery is to the named consignee at the address shown on the document or, in the case of an inland waterway transport document issued in the form of a bill of lading as indicated in section 12.3.6.1, by the surrender of an original inland waterway transport document.12.3.7 Courier receipts, post receipts orcertificates of postingA courier receipt, post receipt or certificate of posting serves as evidence that the goods have been received by a courier service or post office for delivery, and show the name and address of the consignee.12.3.7.1 Title, negotiability and transferThese are not documents of title and are not negotiable documents.12.3.7.2 Control of goodsThe control over the goods remains in the care of the courier company or postal authority.12.3.7.3 Delivery of goodsDelivery is to the named addressee.12.4 Common characteristicsThere are some characteristics common to all types of transport document that need to be understood when they are prepared for presentation under a documentary credit.The following sections refer heavily to ISBP 745 – that is, the International Standard Banking Practice for the Examination of Documents under UCP 600 – the contents of which provide significant guidance as to how each described document should be created in order to comply under a documentary credit.Common characteristics 12.4.1 Consignor or shipper and consigneeAll types of transport document will include boxes, spaces or fields that are to be populated with the names of the consignor or shipper (the party arranging for shipment of the goods) and the consignee (the party receiving or controlling delivery of the goods). Under a documentary credit, the consignor or shipper is usually the beneficiary. This is not an absolute requirement, because any party can be named as consignor or shipper unless the documentary credit states otherwise.The consignee may be a named entity, in which case the document may be referred to as being ‘straight consigned’. If the transport document is issued in negotiable form, it is to show that goods have been consigned to order of a named entity, ‘to order’ or ‘to order of shipper’. If the transport document is consigned ‘to order’ or ‘to order of shipper’, it will need endorsement by the consignor or shipper in blank for it to be negotiable and available for transfer of title, or it is to be endorsed to order of a named entity (as stated in the documentary credit).The consignee requirements for each transport document are as follows.12.4.1.1 For multimodal transport documentsISBP 745, paragraph D16, provides as follows.ISBP 745, paragraph D17, reads as follows.12: Document characteristics and preparing documents 12.4.1.2 For bills of ladingISBP 745, paragraph E12, provides as follows.ISBP 745, paragraph E13, reads as follows.12.4.1.3 For non-negotiable sea waybills ISBP 745, paragraph F11, provides as follows.Common characteristics 12.4.1.4 For charter party bills of ladingISBP 745, paragraph G11, provides as follows.ISBP 745, paragraph G12, reads as follows.12.4.1.5 For air transport documentsISBP 745, paragraph H13, provides as follows.12: Document characteristics and preparing documents12.4.1.6 For road, rail or inland waterway transportdocumentsISBP 745, paragraph J8, provides as follows. Array12.4.2 Notify partyMost types of transport document will make provision for a ‘notify party’ to be inserted. A ‘notify party’ is a party that is to be advised by the carrier, or its agent, upon arrival of goods at the named destination. The notify party will usually be the applicant, its clearing agent or the issuing bank.A documentary credit may or may not require the transport document to indicate a named notify party or parties. If it does not, ISBP 745, paragraphs D18(b)(i) and (ii), E14(b)(i) and (ii), F12(b)(i) and (ii), G13(b)(i) and (ii), H14(b) (i) and (ii), and J9(b)(i) and (ii) all provide similar guidance for the different types of transport document to which they relate.As an example, the following is the text that relates to multimodal transportdocuments, which appears at ISBP 745, paragraph D18(b)(i) and (ii).Common characteristicsIt should be noted that whenever the applicant’s address and contact details appear as part of the notify party details, whether requested in the documentary credit or not, the details must not be in conflict with those stated in the documentary credit.12.4.3 Corrections/alterations to data content Ideally, documents should be presented with no corrections or alterations to their data content. If corrections or alterations have been made or are required to documents not issued by the beneficiary, the beneficiary should consider the possibility of obtaining replacements prior to their presentation in order to minimise the risk of potential disputes arising or to ensure that the proper authentication has been made.At this point, it should be noted that corrections and alterations to documents issued by the beneficiary do not require authentication, with the exception of circumstances described in ISBP 745, paragraph A7(a)(ii). ISBP 745, paragraph A7, provides a general application for a documentexaminer.12: Document characteristics and preparing documentsIn addition, ISBP 745, paragraphs D28 and D29, E24 and E25, F22 and F23, G22 and G23, H23 and H24, and J18 and J19, all provide the authentication requirements for the type of transport document to which they relate.As an example, the following is the text relating to multimodal transport documents, which is found at ISBP 745, paragraphs D28 and D29.12.4.4 Signing requirementsDetailed examination of the different signing requirements for each type of transport document under the respective UCP 600, articles 19–25, is undertaken in Chapter 14. Although it is important that a transport document has been signed in the prescribed manner, this does not mean that every space, box or field shown on a transport document (as requiring a signature) needs to be populated. This position is indicated in ISBP 745, paragraph A37.。