CELL PERMEABLE p18 RECOMBINANT PROTEINS, POLYNUCLE
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专利名称：CELL PERMEABLE p18 RECOMBINANT
PROTEINS, POLYNUCLEOTIDES ENCODING
THE SAME, AND ANTICANCER
COMPOSITION COMPRISING THE SAME 发明人：JO, Daewoong,KIM, Seolhwa,LIM, Jung-
Hee,PARK, Kisuk,KANG, Se-Eun
申请号：EP08828990.5
申请日：20080904
公开号：EP2185709A1
公开日：
20100519
专利内容由知识产权出版社提供
摘要：The present invention discloses cell permeable p18 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a tumor suppressor p18. Also disclosed are polynucleotides encoding the cell permeable p18 recombinant proteins, an expression vector containing the cell permeable p18 recombinant protein, and a pharmaceutical composition for treating p18 deficiency or failure which contains the cell permeable p18 recombinant protein as an effective ingredient. The cell permeable
p18 recombinant proteins of the present invention are capable of efficiently introducing a haploinsufficient tumor suppressor p18 into a cell, and thus, can activate cell signaling mechanisms involved in the activation of ATM and p53 that induce cell cycle arrest and apoptosis in response to DNA damage or oncogenic signals. Therefore, the cell permeable p18 recombinant proteins of the present invention can be effectively used as an anticancer agent.
申请人：Procell Therapeutics Inc.
地址：No 1009, ACE Twin Tower II 212-30 Guro 3-dong, Guro-gu Seoul 152-779 KR 国籍：KR
代理机构：Hatzmann, Martin
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