来曲唑微刺激方案和短方案对卵巢低反应助孕的临床研究

来曲唑微刺激方案和短方案对卵巢低反应助孕的临床研究林敏;刘林丽;陈华;吕杰强
【期刊名称】《实用妇产科杂志》
【年(卷),期】2013(029)007
【摘要】目的:探讨卵巢低反应助孕患者在进行体外受精/卵细胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)治疗中来曲唑(LE)微刺激方案和短方案的应用.方法:回顾性分析进行IVF/ICSI-ET治疗的卵巢低反应患者共206个周期.按治疗方案分短方案组(97周期)和微刺激组(109周期),分别比较两组患者的一般情况、促排卵情况及妊娠结局等.结果:短方案组的促性腺激素(Gn)用量、Gn刺激天数、HCG注射日雌激素(E2)值、≥16 mm卵泡数等均高于微刺激组,差异有统计学意义(P＜0.05).而两组成熟率、正常受精率、卵裂率、周期取消率、生化妊娠率及临床妊娠率比较,差异无统计学意义(P＞0.05),但微刺激组的优质胚胎率显著高于短方案组(P＜0.01).结论:来曲唑微刺激方案是卵巢反应低下患者较理想的促排卵方案.%Objective:To explore the effect of short programs and mini-stimulation protocols of letrozole on patients with poor ovarian response in vitro fertilization and embryo transfer (IVF-ET).Methods:206 clinical cases undergoing IVF-ET were analyzed retrospectively.According to the different administration,they were divided into two groups:109 cycles treated with letrozole plus HMG (mini-stimulation group)and 97 cycles treated with GnRH-a plus Gn (short-stimulation group).Compare the general condition,promoting ovulation rate and the pregnant outcome in each group.Results:There was significant differences between the short-
stimulation group and the mini-stimulation group in the duration and the total dose of gonadotropin,Serum E2 levels on the day of HCG injection and the number of follicles which was ≥16 mm (P＜0.05).And there was no significant difference between the two groups in maturation
rate,fertilization rate,cleavage rate,circle canceling rate and clinical pregnancy rate between the two groups (P ＞ 0.05),while the good-quality embry rate was significantly increased in the mini-stimulation group (P ＜0.01).Conclusions:Mini-stimulation protocol of letrozole is an preferable option for the poor ovarian response infertile patients.
【总页数】3页(P536-538)
【作者】林敏;刘林丽;陈华;吕杰强
【作者单位】温州医学院附属第二医院,浙江温州 325027;温州医学院附属第二医院,浙江温州 325027;温州医学院附属第二医院,浙江温州 325027;温州医学院附属第二医院,浙江温州 325027
【正文语种】中文
【中图分类】R715.2
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