肝动脉栓塞化疗联合微波消融与单纯手术切除对小肝癌疗效比较

肝动脉栓塞化疗联合微波消融与单纯手术切除对小肝癌疗效比
较
谭冠;沈世强;秦峰;黄纯江
【期刊名称】《腹部外科》
【年(卷),期】2016(0)2
【摘要】Objective To compare transcatheter arterial chemoembolization (TACE)combined with microwave ablation (MWA)vs.surgical resection for small hepatocellular carcinoma.Methods The clinical data of 65 patients with small hepatocellular carcinoma treated in our hospital between Jan-uary 2008 and January 2013 were retrospectively analyzed,30 patients accepted TACE combined with MWA,and 35 patients were subjected to surgical resection.The complication rate,1-,2-and 3-year survival rate and recurrence rate were compared between the two groups after treatment.Results The total complication rate in TACE combined with MWA group (10.0%)was significantly lower than in the surgery group
(31.4%)(χ2=4.389,P=0.036).1-,2-,and 3-year recurrence rate was 6.7%, 13.3% and 23.3% in TACE combined with MWA group,and 11.4%,17.1% and 31.4% in the sur-gery group (χ2=0.465,P=0.495).The 1-,2-and 3-year survival rate in TACE combined with MWA group was 93.3%,80.0% and 60.0%,and that was 91.4%,77.1%,and 57.1% in the sur-gery group
(χ2=0.078,P=0.78).Conclusions TACE combined with MWA for small hepatocellular carcinoma is effective,has lower complication rate than
surgical resection,and similar long-term cura-tive effects with the surgical resection.TACE combined with MWA can be considered as the preferred treatment for small hepatocellular carcinoma.%目的对比肝动脉栓塞化疗(TACE)联合微波消融(MWA)与单纯手术切除对小肝癌的治疗效果.方法回顾性分析2008年1月至2013年1月共65例小肝癌病人临床资料.65例中30例行肝动脉栓塞化疗联合微波消融,35例单纯手术切除治疗.比较两组肿瘤治疗后的总并发症发生率,术后1、2、3年生存率和复发率等情况.结果肝动脉栓塞化疗联合微波消融组总并发症发生率为10.0%,低于手术组并发症发生率(31.4%),差异有统计学意义(χ2=4.389,P=0.036).肝动脉栓塞化疗联合微波消融组术后1、2、3年复发率为6.7%、13.3%、23.3%,手术组术后1、2、3年复发率为11.4%、17.1%、31.4%,两组复发率比较差异无统计学意义(χ2=0.465,P=0.495).肝动脉栓塞化疗联合微波消融组术后1、2、3年总生存率为93.3%、80.0%、60.0%,手术组术后1、2、3年总生存率为91.4%、77.1%、57.1%,两组的生存率比较差异无统计学意义(χ2=0.078,P=0.78).结论肝动脉栓塞化疗联合微波消融的治疗效果确切,其术后并发症发生率较低,远期疗效与手术切除相近,可考虑作为小肝癌的首选治疗.
【总页数】4页(P101-104)
【作者】谭冠;沈世强;秦峰;黄纯江
【作者单位】430060 武汉,武汉大学人民医院肝胆外科;430060 武汉,武汉大学人民医院肝胆外科;430060 武汉,武汉大学人民医院肝胆外科;430060 武汉,武汉大学人民医院肝胆外科
【正文语种】中文
【中图分类】R735.7
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