Reserpine_DataSheet_MedChemExpress

Inhibitors, Agonists, Screening Libraries

Data Sheet

BIOLOGICAL ACTIVITY:

Reserpine (Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that irreversibly blocks the vesicular monoamine transporter (VMAT).

Target: vesicular monoamine transporter (VMAT)

Reserpine (Lannett's Serpalan) is an indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side–effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance.

Reserpine irreversibly blocks the vesicular monoamine transporter (VMAT). This normally transports free intracellular norepinephrine,serotonin, and dopamine in the presynaptic nerve terminal into presynaptic vesicles for subsequent release into the synaptic cleft

("exocytosis"). Unprotected neurotransmitters are metabolized by MAO (as well as by COMT) in the cytoplasm and consequently never excite the post–synaptic cell.

References:

[1]. Baumeister AA, et al. The myth of reserpine–induced depression: role in the historical development of the monoamine hypothesis. J Hist Neurosci. 2003Jun;12(2):207–20.

[2]. Henry JP, et al. Radioligands of the vesicular monoamine transporter and their use as markers of monoamine storage vesicles. Biochem Pharmacol. 1989Aug 1;38(15):2395–404.

[3]. Barcelos RC, et al. Short term dietary fish oil supplementation improves motor deficiencies related to reserpine–induced parkinsonism in rats. Lipids. 2011Feb;46(2):143–9.

Product Name:

Reserpine Cat. No.:

HY-N0480CAS No.:

50-55-5Molecular Formula:

C 33H 40N 2O 9Molecular Weight:

608.68Target:

Monoamine Transporter; Autophagy Pathway:

Membrane Transporter/Ion Channel; Autophagy Solubility:

DMSO: 7 mg/mL (Need ultrasonic)

Caution: Product has not been fully validated for medical applications. For research use only.

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