高糖饮食导致大鼠肝脏脂代谢紊乱实验研究

高糖饮食导致大鼠肝脏脂代谢紊乱实验研究
卢贤荣;程万里
【期刊名称】《河北医药》
【年(卷),期】2011(33)9
【摘要】目的探讨高糖饮食对大鼠肝脏过氧化物酶体脂肪酸B-氧化的影响.方法用高糖饮食饲养大鼠24周,观察体重,血清总胆固醇(TC)、三酰甘油(TG)、游离脂肪酸(FFA),肝脏过氧化氢酶、脂酰CoA氧化酶和过氧化物酶体脂肪酸β-氧化活性的变化.结果试验组TG、T℃、FFA与对照组相比有不同程度升高(P<0.01).试验组大鼠肝脏的过氧化氢酶、过氧化物酶体脂肪酸β-氧化、脂酰CoA氧化酶活性较正常对照组明显升高(P<0.05).结论高糖饮食长期摄入可导致大鼠脂质代谢紊乱,肝脏中的过氧化氢酶、脂酰CoA氧化酶和过氧化物酶体脂肪酸β-氧化的活性升高.%Objective To investigate the effect of high glucose diet on the activity of peroxisomal fatty acidβ-oxidation in the livers of rats. Methods The rats were fed with high glucose diet ( experiment group ) or normal diet (control group ) respectively for 24 weeks. The changes of total cholesterol(TC),triglyceride (TG)and free fatty acid (FFA) were observed, an d the changes of the activities of peroxisomal fatty acidβ-
oxidation,hydrogen peroxidase and acyl-CoA oxidase in the livers were detected. Results The levels of TC, TG, FFA in experiment group were increased at different degrees,as compared with those in control group ( P ＜0. 01 ). The activities of hydrogen peroxidase,peroxisomal fatty acidβ-oxidation and acyl-CoA oxidase in experiment group were significantly
increased,as oompared with those in control group ( P ＜ 0.05). Conclusion The long-term taking of high glucose can result in the lipid metabolic disorder in rats, as a result, the activities of hydrogen peroxidase,acyl-CoA oxidase and peroxisomal fatty acidβoxidation are increased.
【总页数】2页(P1307-1308)
【作者】卢贤荣;程万里
【作者单位】050000,河北省石家庄市医疗保险管理中心;中船重工第718研究所【正文语种】中文
【中图分类】R587.1
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