最新治疗方法推荐:英利昔单抗治疗溃疡性结肠炎

最新治疗方法推荐：英利昔单抗治疗溃疡性结肠炎
Das K.M.;赵丽娜
【期刊名称】《世界核心医学期刊文摘：胃肠病学分册》
【年(卷),期】2005(000)002
【摘要】Randomized, controlled studies have shown that infliximab, the chimeric anti- tumor necrosis factor alpha (TNF-α) antibody, is effective for the treatment o f active and fistulizing Crohn’s disease. Because infliximab is beneficial in p atients with Crohn’s disease, in whom other therapies have failed, it has been postulated that infliximab may also be helpful in patients with ulcerative colit is. Many investigators have studied the effectiveness of infliximab in ulcerativ e colitis, mainly in patients who are refractory to corticosteroids. Unfortunate ly, these studies have not yielded a conclusive answer to the efficacy of inflix imab in inducing remission in patients with severe ulcerative colitis. However, some have reported excellent results and others less effective, with the overall data being inconclusive. The purpose of this review is to summarize the current literature on the use of infliximab in ulcerative colitis, aswell as to provide insight into the possible mechanisms of why it may or may not work in these dif ficult-to-treat patients.
【总页数】2页(P52-53)
【作者】Das K.M.;赵丽娜
【作者单位】Crohn’s/Colitis Ctr. of New Jersey;Dept. of Gastroenterol. and Hepatol.;Robert Wood Johnson Medical School;1 Robert Wood Johnson Place;New Brunswick;NJ 08901;United States;Dr.
【正文语种】中文
【中图分类】R574.62
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