文拉法辛合并抗精神病药物治疗精神分裂症阴性症状的疗效观察

文拉法辛合并抗精神病药物治疗精神分裂症阴性症状的疗效观
察
虞华
【期刊名称】《中国生化药物杂志》
【年(卷),期】2017(000)007
【摘要】目的探究文拉法辛合并抗精神病药物治疗精神分裂症阴性症状的疗效观察.方法本次实验选取了2015年6月～2016年11月在本院就诊并确诊的60例精神分裂症患者者,患者随机分为试验组和对照组,各30例.对照组采用单独使用抗精神病药物(利培酮);试验组采用文拉法辛合并抗精神病药物(利培酮).采用阳性和阴性症状量表评价病情,用不良反应症状量表(TESS)评定副反应,以12周为一个研究过程.结果治疗前2组PANSS总分及各因子分相比较差异均无统计学意义.第4、8、12周末试验组阴性因子分与疗前比较差异有统计学意义(P＜0.05);8、12周末对照组阴性因子分与治疗前比较差异有统计学意义(P＜0.05).第4、8、12周末2组间阴性因子分差异均有统计学意义(P＜0.05).不良反应TESS量表比较,2组间差异无统计学意义.结论在利培酮治疗的基础上合并文拉法新对精神分裂症的阴性症状起效快,疗效好,安全性高,值得在临床上推广使用.%Objective To investigate the effect of venlafaxine combined with antipsychotic drugs in the treatment of negative symptoms of schizophrenia.Methods In this study, 60 patients with schizophrenia who were treated and diagnosed in ankang hospital of Hangzhou public security bureau from June 2015 to November 2016 were randomly divided into the experimental group and the control group according to the time of admission.The control group was only
given antipsychotic(risperidone);enrolifloxacin combined with antipsychotics(risperidone)was used in the experimental group.The patients were evaluated with the positive and negative symptoms scale, and the side effects were assessed by the Adverse Reaction Symptom Scale(TESS).A 12-week study was conducted.Results Compared with the results of this experiment, the scores of PANSS and the scores of the two groups were not different between the two groups before and after treatment.4,8,12 weekend negative group of experimental group and the difference was very significant before treatment;8,12 weekend negative control group score and before treatment is relatively poor.There were significant differences in negative factor scores between the two groups at 4, 8 and 12 weeks.There was significant difference between the two groups (P<0.05).Conclusion Risperidone combined with venlafaxine is effective in the treatment of schizophrenia with negative symptoms.It has good curative effect and high safety.It is worth popularizing in clinic.
【总页数】2页(P209-210)
【作者】虞华
【作者单位】杭州市公安局安康医院,浙江杭州 311100
【正文语种】中文
【中图分类】R749.3
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