癌因性疲乏患者血清内分泌激素水平的变化及其与抗肿瘤免疫应答、肿瘤负荷的相关性

癌因性疲乏患者血清内分泌激素水平的变化及其与抗肿瘤免疫
应答、肿瘤负荷的相关性
杨露
【期刊名称】《海南医学院学报》
【年(卷),期】2017(023)016
【摘要】目的:研究癌因性疲乏(CRF)患者血清内分泌激素水平的变化及其与抗肿
瘤免疫应答、肿瘤负荷的相关性.方法:选择在本院诊断为原发性肺癌的137例患者,根据患者的自述症状将入组患者分为CRF组和对照组,采集血清并检测内分泌激素、肿瘤标志物的含量,采集外周血并检测免疫细胞的含量.结果:CRF组血清中ACTH、TSH的含量均显著高于对照组,Cor、FT3、FT4的含量均显著低于对照组;CRF组
外周血中CD11b+CD15﹣CD33+CD14+M-MDSC、CD11b+CD15﹣
CD33+CD14﹣G-MDSC、CD4+CD25+CD127lowTreg、
CD19+CD5+CD1d+Breg的含量以及血清中CEA、Cyfra21-1、SCC-Ag、HE4、GDF-15、PCNA的含量均显著高于对照组且与血清中ACTH、TSH的含量呈正相关,与Cor、FT3、FT4的含量呈负相关.结论:癌因性疲乏患者体内甲状腺激素和肾
上腺皮质激素含量的改变与抗肿瘤免疫应答抑制、肿瘤负荷增加密切相
关.%Objective: To study the changes of serum endocrine hormone levels in patients with cancer-related fatigue (CRF) and their correlation with anti-tumor immune response and tumor load.Methods: A total of 137 patients who were diagnosed with primary lung cancer in West China Hospital, Sichuan University between June 2014 and November 2016 were selected and then divided into CRF group and control group according to their self-
reported symptoms.Serum was collected to determine the levels of endocrine hormones and tumor markers, and peripheral blood was collected to detect the levels of immune cells.Results:Serum ACTH and TSH levels in CRF group were significantly higher than those in control group while Cor, FT3 and FT4 levels were significantly lower than those in control group;peripheral blood CD11b+CD15﹣CD33+CD14+M-MDSC,
CD11b+CD15﹣CD33+CD14﹣G-MDSC, CD4+CD25+CD127lowTreg and CD19+CD5+CD1d+Breg levels as well as serum CEA, Cyfra21-1, SCC-Ag, HE4, GDF-15 and PCNA levels in CRF group were significantly higher than those in control group.Besides, these levels were positively correlated with serum ACTH and TSH levels, and negatively correlated with Cor, FT3 and FT4 levels.Conclusions: The changes of thyroid hormone and adrenal cortical hormone levels in patients with cancer-related fatigue are closely related to the inhibited anti-tumor immune response and increased tumor load.
【总页数】4页(P2243-2246)
【作者】杨露
【作者单位】四川大学华西医院肿瘤一病房,四川成都 610051
【正文语种】中文
【中图分类】R730
【相关文献】
1.化疗患者癌因性疲乏与生存质量、血清皮质醇激素水平的相关性研究 [J], 骆春林
2.绝经前Luminal 型乳腺癌患者血清生殖激素水平与内分泌治疗后血管舒缩功能障碍的相关性研究 [J], 杨慧芬;罗华;杨欧欧;胡祖健;何俊玲;徐海滨
3.绝经前Luminal型乳腺癌患者血清生殖激素水平与内分泌治疗后血管舒缩功能障碍的相关性探究 [J], 王雷;孙贵洋
4.老年高血压合并心力衰竭患者血清神经内分泌激素水平的表达及与心力衰竭严重程度的相关性研究 [J], 胡荣权;苏伟青
5.康复期结肠癌患者癌因性疲乏与血清内分泌激素水平的相关性 [J], 司小敏;张消;焦婉;代晓强;毛维
因版权原因，仅展示原文概要，查看原文内容请购买。