瑞舒伐他汀对动脉粥样硬化斑块中补体因子H表达的影响

瑞舒伐他汀对动脉粥样硬化斑块中补体因子H表达的影响钱琦;陈忠;马根山
【期刊名称】《中国生化药物杂志》
【年(卷),期】2011(32)6
【摘要】目的研究瑞舒伐他汀对载脂蛋白E基因缺陷小鼠(ApoE-/-小鼠)动脉粥样硬化处补体因子H(CFH)表达的影响.方法 8周龄ApoE-/-小鼠随机分为4组:模型组Ⅰ(高脂饲料喂养10周)、模型组Ⅱ(高脂饲料喂养20周)、预防组(在给予高脂饲料的同时予瑞舒伐他汀预防性给药10周)和治疗组(于高脂饲料喂养10周后,给予瑞舒伐他汀,嚷至20周).阶段试验结束时取主动脉做HE染色及免疫组化,检测CFH mRNA转录和蛋白表达水平；检测血脂及血清hsCRP、C3a水平.结果与模型组Ⅰ和模型组Ⅱ比较,预防组及治疗组ApoE-/-小鼠主动脉内膜和斑块内CFH表达增多；CFH的mRNA转录水平和蛋白表达水平升高；血脂、hsCRP、C3a水降低(P＜0.01或0.05).结论瑞舒伐他汀降低血脂水平,降低动脉粥样硬化的炎症免疫反应,增加CFH表达.%Purpose To investigate the effect of rosuvastatin on expression of complement factor H (CFH) in atherosclerosis ( AS) of apolipoprotein E-knoekout( ApoE-/-) Mice. Methods Eight weeks old ApoE-/-mice were divided randomly into four groups[ model group I : AS model fed for 10 weeks(n = 14) ,model group II ; AS model fed for 20 weeks(n = 14) , prevention group(n =8) and treatment group (n = 8) ]. After experiment, the aortas were taken for HE, immunohistochemistry CFH stain, RT-PCR and western blotting at the 10th and 20th week with continuous intragastric administration respectively. Results The CFH
expression is outstanding in prevention group and treatment group than that in model group I and H. Prevention or therapy with rosuvastatin could upregulate CFH mRNA expression and increase the level of CFH protein. Serum hsCRP,and C3a levels were significantly decreased in the prevention group and treatment group relative to model group I and II (P<0.01,or0. OS). Conclusion Rosuvastatin can increase the expression of CFH.
【总页数】5页(P458-462)
【作者】钱琦;陈忠;马根山
【作者单位】南京医科大学第二附属医院心内科,江苏南京210011;东南大学附属中大医院心内科,江苏南京210009;东南大学附属中大医院心内科,江苏南京210009
【正文语种】中文
【中图分类】R962
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