电针对阿尔茨海默病大鼠认知功能及海马 Nogo-A 、NgR 表达的影响

电针对阿尔茨海默病大鼠认知功能及海马 Nogo-A 、NgR
表达的影响
王辉;何娅;陈松盛;马巧亚;王锐利
【期刊名称】《陕西医学杂志》
【年(卷),期】2015(000)002
【摘要】Objective:To observe the effects of electro‐acupuncture on cognitive functions and expression of Nogo‐A and NgR in hippocampus of Alzheimer’s disease rats .Methods :The rats of Alzheimer’s disease were es‐tablished by injection β amyloid 1‐40 into bilateral hippocampus and were treated with electro‐acupuncture for twenty days after one week .The cognitive functions were evaluated by Morris water maze testing in fifth week and the ex ‐pression of Nogo‐A and NgR in hippocampus were detected by Western Blot .Results :The escape latency of rats in AD group was significantly longer than that in sham‐operated group and was significantly shorter in electro‐acupunc‐t ure group than that in AD
group .The percentage of swimming time in the original quadrant in AD group was sig ‐nificantly lower than that in sham‐operated group and was significantly higher in electro‐acupuncture group than in AD group .The down‐regulated Nogo‐A and up‐regulated NgR were discovered in AD group and were corrected by electro‐acupuncture .Conclusion :The Nogo‐A up‐regulation and NgR down‐regulation in AD rats have relationship with the pathological changes .The treatments of electro‐acupunctur e
obviously improved the cognitive functions ,of which the change of NgR expression are supposed to be one of the mechanisms .%目的：了解电针对阿尔茨海默病（AD）大鼠认知功能及海马区Nogo‐A 、NgR 表达的影响。

方法：双侧海马注射Aβ1‐40制备大鼠 AD 模型，1周后加电针治疗，第5周行水迷宫
实验评价大鼠认知功能，并用 Western Blot 方法检测海马区 Nogo‐A 、NgR 表达的变化。

结果：水迷宫实验中逃避潜伏期在 AD 组大鼠较假手术组显著延长（P ＜0．05），而 AD ＋电针组较 AD 组显著缩短（P＜0．05）。

原平台所在象限
的游泳时间占总时间的比值 AD 组大鼠显著低于假手术组（P ＜0． 05），而 AD ＋电针组则显著高于 AD 组（P ＜0．05）。

Western Blot 实验显示：AD 组大
鼠较假手术组Nogo‐A 表达增高，NgR 表达降低，AD ＋电针组大鼠较 AD 组Nogo‐A 表达则相对下调，NgR 表达相对上调。

结论：AD 大鼠海马区Nogo‐A 表达增高，NgR 表达降低，可能与 AD 的病理改变有一定联系。

电针治疗能明显
改善 AD 大鼠的认知功能，上调 NgR 表达可能是其机制之一。

【总页数】4页(P147-150)
【作者】王辉;何娅;陈松盛;马巧亚;王锐利
【作者单位】西安交通大学第二附属医院老年神经科西安 710004;西安交通大学
第二附属医院老年神经科西安 710004;西安交通大学第二附属医院老年神经科西安 710004;西安交通大学第二附属医院老年神经科西安 710004;西安交通大学第
二附属医院老年神经科西安 710004
【正文语种】中文
【中图分类】R749.16
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